CN109718708A - A kind of solid-liquid hybrid system and method for pharmaceutical production - Google Patents
A kind of solid-liquid hybrid system and method for pharmaceutical production Download PDFInfo
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- CN109718708A CN109718708A CN201910041138.9A CN201910041138A CN109718708A CN 109718708 A CN109718708 A CN 109718708A CN 201910041138 A CN201910041138 A CN 201910041138A CN 109718708 A CN109718708 A CN 109718708A
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Abstract
The present invention relates to a kind of solid-liquid hybrid systems for pharmaceutical production, including blending tank, input duct, liquid outlet pipe, mixing duct, circulating line, finished product pipeline, waste pipe, the first triple valve, the second triple valve, solid storage tank, feed pipe, discharge pipe, gate valve, self priming pump, mixing pump, cleaning pipeline, the first branch pipe(tube) and the second branch pipe(tube).Further relate to a kind of solid-liquid mixed method for pharmaceutical production.It the advantage is that, solid material is fed using the method for vacuum suction, solid material is made to feed dustlessization, guarantees production environment without fugitive dust；Solid-liquid mixing is carried out using endless form, without agitating device is used, solid-liquid mixing efficiency is not only improved, also reduces the energy consumption of mixed process；By on-line cleaning, blending tank and solid storage tank are thoroughly cleaned, prevented raw material cross contamination, guarantees the quality of production of drug.
Description
Technical field
The present invention relates to drug solid-liquid hybrid technology field more particularly to a kind of solid-liquid hybrid systems for pharmaceutical production
And method.
Background technique
In pharmaceutical production, solid-liquid mixing efficiency seriously restricts pharmaceutical production efficiency, and industrial circle always searches for properly
And efficient solid-liquid hybrid mode.
In addition, in solid-liquid mixed process, therefore, to assure that the airtightness in the operating process of charging, mixing and discharging,
Prevent open operation.After discharging, that is, after the completion of producing, it is also necessary to be cleaned to equipment, to improve solid-liquid mixing
While efficiency, meet the requirement of clear production, Improving The Quality of Products, and improve production environment.
But traditional feeding manner is open charging, so that there is fugitive dust, Wu Fajin in fill process in solid material
The totally enclosed charging of row influences the health of operator, and make to the quality of pharmaceutical production so that production environment is severe
At greater risk.In addition, being difficult to carry out feeding device effectively and thoroughly clear after being fed using traditional feeding manner
It washes, each corner of feeding device can be especially adhered to after solid material dampness, causes cleaning to be not thorough, and then influence drug
Production.
Chinese utility model patent ZL201621054254.2 discloses a kind of high efficiency solid-liquid mixing arrangement, although improving
Solid-liquid mixing efficiency, but its solid material is still open operation, can not accomplish to be completely closed, and can not also be carried out online
Cleaning, not only influences product quality, causes drug cross contamination, and drug fugitive dust influences production environment, endangers operator
Health.
Therefore, need one kind can dustlessization operation, avoid solid material fugitive dust, solid-liquid mixed high-efficient, low energy consumption, carry out
The thoroughly solid-liquid hybrid system and solid-liquid mixed method of on-line cleaning.
Summary of the invention
The purpose of the present invention is aiming at the shortcomings in the prior art, provide a kind of solid-liquid mixed stocker for pharmaceutical production
System.
To achieve the above object, the technical solution adopted by the present invention is that:
A kind of solid-liquid hybrid system for drug, comprising:
Blending tank, the upper end of the blending tank are connected to the first end of input duct, the lower end of the blending tank and liquid out
The first end of pipeline is connected to；
Mixing duct, the first end of the mixing duct are connected to the second end of the liquid outlet pipe；
Circulating line, the first end of the circulating line are connected to the second end of the mixing duct, the circulating line
Second end be connected to the upper end of the blending tank；
The first end of finished product pipeline, the finished product pipeline is connected to the second end of the mixing duct；
Waste pipe, the first end of the waste pipe are connected to the second end of the liquid outlet pipe；
The first end of first triple valve, first triple valve is connected to the second end of the liquid outlet pipe, and described first
The second end of triple valve is connected to the first end of the mixing duct, the third end of first triple valve and the waste pipe
First end connection；
The first end of second triple valve, second triple valve is connected to the second end of the mixing duct, and described second
The second end of triple valve is connected to the first end of the circulating line, the third end of second triple valve and the finished product pipeline
First end connection；
Solid storage tank, the upper end of the solid storage tank respectively with the first end of feed pipe, vacuum pipe first
End connection, the lower end of the solid storage tank is connected to the first end of discharge pipe；
Gate valve, the first end of the gate valve are connected to the second end of the discharge pipe, and the second of the gate valve
End is connected to the mixing duct；
Self priming pump, self priming pump setting in the mixing duct, the self priming pump setting the gate valve with it is described
Between second triple valve；
Mixing pump, mixing pump setting in the mixing duct, the mixing pump setting the self priming pump with it is described
Between second triple valve；
Clean pipeline, the cleaning pipeline include the first branch pipe(tube) and the second branch pipe(tube), the first of first branch pipe(tube)
It holds and is connected to the second end of the cleaning pipeline, the second end of first branch pipe(tube) is connected to the upper end of the blending tank, institute
The first end of the second branch pipe(tube) is stated to be connected to the second end of the cleaning pipeline, the second end of second branch pipe(tube) with it is described solid
The upper end of body storage tank is connected to.
Preferably, further includes:
Visor, the visor are arranged in the mixing duct, and the visor is located at the mixing pump and second threeway
Between valve.
Preferably, the mixing pump is shear pump.
Preferably, the second end of first branch pipe(tube) is provided with the first spray equipment, and first spray equipment is located at
In the blending tank.
Preferably, the second end of second branch pipe(tube) is provided with the second spray equipment, and second spray equipment is located at
The inside of the solid storage tank.
The present invention also provides a kind of solid-liquid mixed method for pharmaceutical production, it is suitable for raw for drug as described above
The solid-liquid hybrid system of production, comprising the following steps:
Step 1, feed process
Material liquid enters in blending tank from input duct, and solid material enters in solid storage tank from feed pipe；
Step 2, mixed processes
Step 21, the first triple valve of switching, make the second of the first end of first triple valve and first triple valve
End connection；
Step 22, the second triple valve of switching, make the second of the first end of second triple valve and second triple valve
End connection；
Step 23 opens gate valve and opens self priming pump and mixing pump, and the self priming pump draws the material liquid and described
Solid material is simultaneously delivered to the mixing pump, and the material liquid enters mixing duct through liquid outlet pipe from the blending tank, described
Solid material enters the mixing duct through discharge pipe, and the mixing pump mixes the material liquid and the solid material with shape
At mixed liquor, the mixed liquor is delivered to the blending tank through circulating line by the mixing pump；
Step 3, discharge process
Switch second triple valve, the third end of the first end and second triple valve that make second triple valve connects
Logical, the mixed liquor is successively exported through the discharge pipe and the mixing duct from finished product pipeline；
Step 4, cleaning process
Step 41, switching second triple valve, make the first end of second triple valve and second triple valve
Second end connection；
Step 42, ejected wash water from cleaning pipeline by the first branch pipe(tube) and the second branch pipe(tube) respectively enter the blending tank and
The solid storage tank, the ejected wash water enter the mixing duct, institute from the blending tank and the solid storage tank respectively
It states mixing pump and the ejected wash water is delivered to the blending tank through the circulating line；
Step 43 stops to ejected wash water described in the cleaning pipeline, and switches first triple valve, makes described
The first end of one triple valve is connected to the third end of first triple valve, and the ejected wash water is through the discharge pipe from waste pipe
Road discharge.
Preferably, in the step 2, step 23 is repeated at least twice.
Preferably, in the step 4, step 42 is repeated at least twice.
Preferably, the solid-liquid hybrid system for pharmaceutical production further includes visor, and the visor setting is described mixed
Pipeline is closed, the visor is between the mixing pump and second triple valve；
In described 23, the mixed liquor is successively delivered to institute through the visor and the circulating line by the mixing pump
State blending tank.
Preferably, the solid-liquid hybrid system for pharmaceutical production further includes the first spray equipment and the second spray dress
It sets, first spray equipment is arranged in the second end of first branch pipe(tube) and is located in the blending tank, second spray
Shower device is arranged in the second end of second branch pipe(tube) and is located in the solid storage tank；
In the step 42, the ejected wash water is successively through the cleaning pipeline, first branch pipe(tube) and described first
Spray equipment cleans the blending tank, and the ejected wash water is successively through the cleaning pipeline, second branch pipe(tube) and institute
The second spray equipment is stated to clean the solid storage tank.
The invention adopts the above technical scheme, compared with prior art, has the following technical effect that
A kind of solid-liquid hybrid system and method for pharmaceutical production of the invention, to solid material using vacuum suction
Method is fed, and solid material is made to feed dustlessization, guarantees production environment without fugitive dust；It is mixed that solid-liquid is carried out using endless form
It closes, without agitating device is used, not only improves solid-liquid mixing efficiency, also reduce the energy consumption of mixed process；It is right by on-line cleaning
Blending tank and solid storage tank are thoroughly cleaned, and raw material cross contamination has been prevented, and guarantee the quality of production of drug.
Detailed description of the invention
Fig. 1 is the schematic diagram of an illustrative examples of the invention.
Fig. 2 is the schematic diagram of a preferred embodiment of the present invention.
Appended drawing reference therein are as follows: blending tank 1；Input duct 2；Liquid outlet pipe 3；Mixing duct 4；Circulating line 5；Finished product
Pipeline 6；Waste pipe 7；First triple valve 8；Second triple valve 9；Solid storage tank 10；Feed pipe 11；Vacuum pipe 12；Out
Pipe material 13；Gate valve 14；Self priming pump 15；Mixing pump 16；Clean pipeline 17；First branch pipe(tube) 18；Second branch pipe(tube) 19；Visor
20；First spray equipment 21；Second spray equipment 22.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art without creative labor it is obtained it is all its
His embodiment, shall fall within the protection scope of the present invention.
It should be noted that in the absence of conflict, the feature in embodiment and embodiment in the present invention can phase
Mutually combination.
The present invention will be further explained below with reference to the attached drawings and specific examples, but not as the limitation of the invention.
Embodiment 1
An illustrative examples of the invention, as shown in Figure 1, a kind of solid-liquid hybrid system for pharmaceutical production, packet
Include mixing arrangement, solid material feeders and cleaning device.
Mixing arrangement includes blending tank 1, mixing duct 4, circulating line 5, finished product pipeline 6, blending tank 1 and mixing duct 4
Circulation loop is formed with circulating line 5, finished product pipeline 6 is connected to mixing duct 4, the mixed liquor mixed is discharged.
The upper end of blending tank 1 is connected to the first end of input duct 2, the lower end of blending tank 1 and the first end of liquid outlet pipe 3
Connection, the second end of liquid outlet pipe 3 are connected to the first end of mixing duct 4, second end and the circulating line 5 of mixing duct 4
First end connection, the second end of circulating line 5 are connected to the upper end of blending tank 1.
The connectivity part of liquid outlet pipe 3 and mixing duct 4 is provided with the first triple valve 8, the first end of the first triple valve 8 with
The second end of liquid outlet pipe 3 is connected to, and the second end of the first triple valve 8 is connected to the first end of mixing duct 4.
The connectivity part of mixing duct 4 and circulating line 5 is provided with the second triple valve 9, the first end of the second triple valve 9 with
The second end of mixing duct 4 is connected to, and the second end of the second triple valve 9 is connected to the first end of circulating line 5, the second triple valve 9
Third end be connected to the first end of finished product pipeline 4.
Self-priming is disposed with from the first end of mixing duct 4 between the second end of mixing duct 4 on mixing duct 4
Pump 15 and mixing pump 16.
Further, mixing pump 16 is shear pump.
Solid material feeders include solid storage tank 10, feed pipe 11, vacuum pipe 12, discharge pipe 13 and insert
Plate valve 14, the upper end of solid storage tank 10 are connected to the first end of the first end of feed pipe 11 and vacuum pipe 12 respectively, Gu
The lower end of body storage tank 10 is connected to the first end of discharge pipe 13, and the second end of discharge pipe 13 is connected to mixing duct 4, is inserted
Plate valve 14 is arranged between the first end and second end of discharge pipe 13.
The connectivity part of discharge pipe 13 and mixing duct 4 is located between the first end and self priming pump 15 of mixing duct 4.
Cleaning device includes cleaning pipeline 17 and waste pipe 7, and cleaning pipeline 17 includes the first branch pipe(tube) 18 and second
The first end of pipeline 19, the first branch pipe(tube) 18 is connected to the second end of cleaning pipeline 17, and the second end of the first branch pipe(tube) 18 is goed deep into
In blending tank 1, the first end of the second branch pipe(tube) 19 is connected to the second end of cleaning pipeline 17, and the second end of the second branch pipe(tube) 19 is deep
Enter in solid storage tank 10, the first end of waste pipe 7 is connected to the third end of the first triple valve 8.
The solid-liquid mixed method for pharmaceutical production of the present embodiment is as follows:
Step 1, feed process
Material liquid enters in blending tank 1 from input duct 2, and solid material enters solid storage tank 10 from feed pipe 11
It is interior.
In solid material charging, the second end of feed pipe 11 is goed deep into solids material bag, opens vacuum plant, vacuum
Device vacuumizes solid storage tank 10 by vacuum pipe 12, under the suction function in solid storage tank 10, solid
Material enters in solid storage tank 10 from feed pipe 11.
Further, material liquid and solid material can be disposable charging, be also possible to repeatedly feed in batches.
Step 2, mixed processes
Step 21, the first triple valve 8 of switching, the second end of the first end and the first triple valve 8 that make the first triple valve 8 connect
It is logical, even if liquid outlet pipe 3 is connected to mixing duct 4.
Step 22, the second triple valve 9 of switching, the second end of the first end and the second triple valve 9 that make the second triple valve 9 connect
It is logical, even if mixing duct 4 is connected to circulating line 5.
Step 23 opens gate valve 14 and opens self priming pump 15 and mixing pump 16, and self priming pump 15 is distinguished in preset ratio
It draws material liquid and solid material and is delivered to mixing pump 16, material liquid enters mixing duct 4 through liquid outlet pipe 3 from blending tank 1,
Solid material enters mixing duct 4 through discharge pipe 13, and 16 mixed raw material liquid of mixing pump and solid material are mixed with forming mixed liquor
It closes pump 16 and mixed liquor is delivered to blending tank 1 through circulating line 5.
It in step 23, needs to recycle mixed liquor in mixing arrangement at least twice, that is, needs to repeat step 23 at least
Twice, so that material liquid and solid material are uniformly mixed.
Step 3, discharge process
Switch the second triple valve 9, be connected to the first end of the second triple valve 9 and the third end of the second triple valve 9, even if mixed
It closes pipeline 4 to be connected to finished product pipeline 6, mixed liquor after mixing is successively through discharge pipe 13 and mixing duct 4 from production tube
Road 6 exports.
Step 4, cleaning process
Step 41, the second triple valve 9 of switching, the second end of the first end and the second triple valve 9 that make the second triple valve 9 connect
It is logical, even if mixing duct 4 is connected to circulating line 5.
Step 42, ejected wash water respectively enter blending tank by the first branch pipe(tube) 18 and the second branch pipe(tube) 19 from cleaning pipeline 17
1 and solid storage tank 10, ejected wash water enters mixing duct 4 from blending tank 1 and solid storage tank 10 respectively, and mixing pump 16 will clean
Water is delivered to blending tank 1 through circulating line 5.
Step 43 stops conveying ejected wash water to cleaning pipeline 17, and switches the first triple valve 8, makes the of the first triple valve 8
One end is connected to the third end of the first triple valve 8, even if liquid outlet pipe 3 is connected to waste pipe 7, ejected wash water is through discharge pipe 13
It is discharged from waste pipe 7.
In step 42, it needs to recycle ejected wash water in mixing arrangement at least twice, that is, needs to repeat step 42 at least
Twice, blending tank 1 and solid storage tank 10 is enabled thoroughly to be cleaned.
The solid-liquid hybrid system and solid-liquid mixed method for pharmaceutical production of the present embodiment, by solid material it is closed into
Material, avoids occurring fugitive dust in production environment；By the way that circulation loop is arranged, so that solid-liquid carries out under the action of device without mixing
Efficiently mixing；Using on-line cleaning and ejected wash water is recycled, blending tank and solid storage tank can thoroughly be cleaned, be kept away
Exempt from drug cross contamination occur, improves drug quality.
Embodiment 2
The present embodiment is a preferred embodiment of the present invention, and the present embodiment carries out further on the basis of embodiment 1
Optimization.
As shown in Fig. 2, the solid-liquid hybrid system for pharmaceutical production of the present embodiment, on the basis of embodiment 1, into one
Step includes: visor 20, the first spray equipment 21 and the second spray equipment 22.
Visor 20 is arranged on mixing duct 4, and between mixing pump 16 and the second end of mixing duct 4.
The second end of the first branch pipe(tube) 18 is arranged in first spray equipment 21, and the second spray equipment 22 is arranged in the second branch pipe
The second end in road 19.
The mixed effect through the mixed mixed liquor of mixing pump 16 can be observed by visor 20, it can from mixed liquor
Clarification degree judges mixability, and observation mixed liquor operational circumstances, prevents contingency.
Blending tank 1 and solid storage tank 10 can be carried out respectively by the first spray equipment 21 and the second spray equipment 22
More thoroughly wash.
The solid-liquid mixed method for pharmaceutical production of the present embodiment, step is substantially the same as embodiment 1, in which:
In step 23, mixed liquor is successively delivered to blending tank 1 through visor 20 and circulating line 5 by mixing pump 16.
In step 42, ejected wash water successively cleaned pipeline 17, the first branch pipe(tube) 18 and 21 pairs of the first spray equipment mixing
Tank 1 is cleaned, ejected wash water successively cleaned pipeline 17, the second branch pipe(tube) 19 and the second spray equipment 22 to solid storage tank 10
It is cleaned.
The solid-liquid hybrid system and solid-liquid mixed method for pharmaceutical production of the present embodiment can be with by increasing visor
Solid-liquid troubled water is observed and is prevented contingency；Pass through the first spray equipment of setting and the second spray dress
It sets, blending tank and solid storage tank can more be thoroughly washed, avoid the occurrence of drug cross contamination.
In order to verify the present embodiment practical application reliability, inventor carries out two groups of control experiments, as follows:
Experimental group 1
Certain pharmaceutical factory is water mainly for the production of drug, material liquid 5000kg, liquid, and solid material inventory is
1000kg, granular material obtain following data using the solid-liquid hybrid system and solid-liquid mixed method of the present embodiment:
Feed intake process: 0.5 hour.
Workshop section personnel setting: operation 1 people of number.
Solid dust leakage has not been monitored during feeding intake.
Mixture is detected after mixing, mixture degree of scatter is uniform；And after on-line cleaning, blending tank and solid storing
The equal noresidue solid of tank.
Control group 1
Certain pharmaceutical factory is water mainly for the production of drug, material liquid 5000kg, liquid, and solid material inventory is
1000kg, granular material obtain following data using traditional solid-liquid hybrid system and solid-liquid mixed method:
Feed intake process: 2 hours.
Workshop section personnel setting: operation 1 people of number.
Solid dust leakage has been monitored during feeding intake.
Mixture is detected after mixing, mixture degree of scatter is more uniform；And after on-line cleaning, blending tank and solid storage
Batch can has a small amount of residual solids.
By experimental group 1 compared with control group 1, it can be found that being adopted in mixed phase under the cleaning of material liquid and solid material
With solid-liquid hybrid system and solid-liquid mixed method of the invention, solid feeds intake no fugitive dust, and mixture degree of scatter is uniform, and online
After cleaning, remained in blending tank and solid storage tank without solid material.
Experimental group 2
Certain pharmaceutical factory is lanolin mainly for the production of drug, material liquid 5000kg, liquid, and solid material inventory is
1000kg, granular material obtain following data using the solid-liquid hybrid system and solid-liquid mixed method of the present embodiment:
Feed intake process: 1 hour.
Workshop section personnel setting: operation 1 people of number.
Solid dust leakage has not been monitored during feeding intake.
Mixture is detected after mixing, mixture degree of scatter is uniform；And after on-line cleaning, blending tank and solid storing
The equal noresidue solid of tank.
Control group 2
Certain pharmaceutical factory is lanolin mainly for the production of drug, material liquid 5000kg, liquid, and solid material inventory is
1000kg, granular material obtain following data using traditional solid-liquid hybrid system and solid-liquid mixed method:
Feed intake process: 2 hours.
Workshop section personnel setting: operation 1 people of number.
Solid dust leakage has been monitored during feeding intake.
Mixture is detected after mixing, mixture degree of scatter is uneven；And after on-line cleaning, blending tank and solid storage
Batch can has a small amount of residual solids.
By experimental group 2 compared with control group 2, it can be found that being adopted in mixed phase under the cleaning of material liquid and solid material
With solid-liquid hybrid system and solid-liquid mixed method of the invention, solid feeds intake no fugitive dust, and mixture degree of scatter is uniform, and online
After cleaning, remained in blending tank and solid storage tank without solid material.
Solid-liquid hybrid system and solid-liquid mixed method for pharmaceutical production of the invention, by being fed to solid material
Cheng Jinhang airtightness operation, so that production environment solves the solid material of toxic sensitization to operator's without fugitive dust
Safe and healthy influence；And by circulation loop, under the action of device without mixing, carries out efficiently solid-liquid and mix；And pass through
On-line cleaning thoroughly cleans blending tank and solid storage tank, avoids drug cross contamination, improves solid-liquid mixing effect
Rate reduces the energy consumption in mixed process, and drug quality is good, achieves preferable technical effect.
The foregoing is merely preferred embodiments of the present invention, are not intended to limit embodiments of the present invention and protection model
It encloses, to those skilled in the art, should can appreciate that all with made by description of the invention and diagramatic content
Equivalent replacement and obviously change obtained scheme, should all be included within the scope of the present invention.
Claims (10)
1. a kind of solid-liquid hybrid system for pharmaceutical production characterized by comprising
The upper end of blending tank (1), the blending tank (1) is connected to the first end of input duct (2), under the blending tank (1)
End is connected to the first end of liquid outlet pipe (3)；
The first end of mixing duct (4), the mixing duct (4) is connected to the second end of the liquid outlet pipe (3)；
The first end of circulating line (5), the circulating line (5) is connected to the second end of the mixing duct (4), the circulation
The second end of pipeline (5) is connected to the upper end of the blending tank (1)；
The first end of finished product pipeline (6), the finished product pipeline (6) is connected to the second end of the mixing duct (4)；
The first end of waste pipe (7), the waste pipe (7) is connected to the second end of the liquid outlet pipe (3)；
The first end of first triple valve (8), first triple valve (8) is connected to the second end of the liquid outlet pipe (3), described
The second end of first triple valve (8) is connected to the first end of the mixing duct (4), the third end of first triple valve (8)
It is connected to the first end of the waste pipe (7)；
The first end of second triple valve (9), second triple valve (9) is connected to the second end of the mixing duct (4), described
The second end of second triple valve (9) is connected to the first end of the circulating line (5), the third end of second triple valve (9)
It is connected to the first end of the finished product pipeline (6)；
Solid storage tank (10), the upper end of the solid storage tank (10) respectively with the first end of feed pipe (11), vacuum tube
The first end in road (12) is connected to, and the lower end of the solid storage tank (10) is connected to the first end of discharge pipe (13)；
The first end of gate valve (14), the gate valve (14) is connected to the second end of the discharge pipe (13), the plate
The second end of valve (14) is connected to the mixing duct (4)；
Self priming pump (15), self priming pump (15) setting are inserted in the mixing duct (4), self priming pump (15) setting described
Between plate valve (14) and second triple valve (9)；
Mixing pump (16), the mixing pump (16) setting in the mixing duct (4), mixing pump (16) setting it is described from
Between sucking pump (15) and second triple valve (9)；
Clean pipeline (17), the cleaning pipeline (17) include the first branch pipe(tube) (18) and the second branch pipe(tube) (19), described first
The first end of branch pipe(tube) (18) with it is described cleaning pipeline (17) second end be connected to, the second end of first branch pipe(tube) (18) and
The upper end of the blending tank (1) is connected to, the second end of the first end of second branch pipe(tube) (19) and cleaning pipeline (17)
Connection, the second end of second branch pipe(tube) (19) are connected to the upper end of the solid storage tank (10).
2. the solid-liquid hybrid system according to claim 1 for pharmaceutical production, which is characterized in that further include:
Visor (20), the visor (20) are arranged in the mixing duct (4), and the visor (20) is located at the mixing pump (16)
Between second triple valve (9).
3. the solid-liquid hybrid system according to claim 1 for pharmaceutical production, which is characterized in that the mixing pump (16)
For shear pump.
4. the solid-liquid hybrid system according to claim 1 for pharmaceutical production, which is characterized in that first branch pipe(tube)
(18) second end is provided with the first spray equipment (21), and first spray equipment (21) is located in the blending tank (1).
5. the solid-liquid hybrid system according to claim 1 for pharmaceutical production, which is characterized in that second branch pipe(tube)
(19) second end is provided with the second spray equipment (22), and second spray equipment (22) is located at the solid storage tank (10)
Inside.
6. a kind of solid-liquid mixed method for pharmaceutical production, suitable for being used for consolidating for pharmaceutical production as described in claim 1
Liquid mixing system, which comprises the following steps:
Step 1, feed process
Material liquid enters in blending tank (1) from input duct (2), and solid material enters solid storage tank from feed pipe (11)
(10) in；
Step 2, mixed processes
Step 21, switching the first triple valve (8), make the first end of first triple valve (8) and first triple valve (8)
Second end connection；
Step 22, switching the second triple valve (9), make the first end of second triple valve (9) and second triple valve (9)
Second end connection；
Step 23 opens gate valve (14) and opens self priming pump (15) and mixing pump (16), described in self priming pump (15) absorption
Material liquid and the solid material are simultaneously delivered to the mixing pump (16), and the material liquid is from the blending tank (1) through outlet tube
Road (3) enters mixing duct (4), and the solid material enters the mixing duct (4) through discharge pipe (13), the mixing pump
(16) material liquid and the solid material are mixed to form mixed liquor, the mixing pump (16) is by the mixed liquor through recycling
Pipeline (5) is delivered to the blending tank (1)；
Step 3, discharge process
Switch second triple valve (9), make second triple valve (9) first end and second triple valve (9) the
The connection of three ends, the mixed liquor are successively exported through the discharge pipe (13) and the mixing duct (4) from finished product pipeline (6)；
Step 4, cleaning process
Step 41, switching second triple valve (9), make the first end of second triple valve (9) and second triple valve
(9) second end connection；
Step 42, ejected wash water are respectively enterd from cleaning pipeline (17) by the first branch pipe(tube) (18) and the second branch pipe(tube) (19) described
Blending tank (1) and the solid storage tank (10), the ejected wash water is respectively from the blending tank (1) and the solid storage tank
(10) enter the mixing duct (4), the ejected wash water is delivered to described by the mixing pump (16) through the circulating line (5)
Blending tank (1)；
Step 43 stops conveying the ejected wash water to the cleaning pipeline (17), and switches first triple valve (8), makes institute
The first end for stating the first triple valve (8) is connected to the third end of first triple valve (8), and the ejected wash water is through the discharge nozzle
Road (13) is discharged from waste pipe (7).
7. the solid-liquid mixed method according to claim 6 for pharmaceutical production, which is characterized in that in the step 2,
Repeat step 23 at least twice.
8. the solid-liquid mixed method according to claim 6 for pharmaceutical production, which is characterized in that in the step 4,
Repeat step 42 at least twice.
9. the solid-liquid mixed method according to claim 6 for pharmaceutical production, which is characterized in that described raw for drug
The solid-liquid hybrid system of production further includes visor (20), and the visor (20) is arranged in the mixing duct (4), the visor (20)
Between the mixing pump (16) and second triple valve (9)；
In described 23, the mixing pump (16) is by the mixed liquor successively through the visor (20) and the circulating line (5)
It is delivered to the blending tank (1).
10. the solid-liquid mixed method according to claim 6 for pharmaceutical production, which is characterized in that described to be used for drug
The solid-liquid hybrid system of production further includes the first spray equipment (21) and the second spray equipment (22), first spray equipment
(21) second end in first branch pipe(tube) (18) is set and is located in the blending tank (1), second spray equipment
(22) second end in second branch pipe(tube) (19) is set and is located in the solid storage tank (10)；
In the step 42, the ejected wash water is successively through the cleaning pipeline (17), first branch pipe(tube) (18) and described
First spray equipment (21) cleans the blending tank (1), and the ejected wash water is successively through the cleaning pipeline (17), described
Second branch pipe(tube) (19) and second spray equipment (22) clean the solid storage tank (10).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910041138.9A CN109718708A (en) | 2019-01-16 | 2019-01-16 | A kind of solid-liquid hybrid system and method for pharmaceutical production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910041138.9A CN109718708A (en) | 2019-01-16 | 2019-01-16 | A kind of solid-liquid hybrid system and method for pharmaceutical production |
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| CN110885445A (en) * | 2019-11-01 | 2020-03-17 | 湖州美伦纺织助剂有限公司 | Novel quaternary ammonium salt modified silicone oil and production process thereof |
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