CN109706069A - A kind of culture dish and production method applied to drug sensitive test - Google Patents
A kind of culture dish and production method applied to drug sensitive test Download PDFInfo
- Publication number
- CN109706069A CN109706069A CN201910191254.9A CN201910191254A CN109706069A CN 109706069 A CN109706069 A CN 109706069A CN 201910191254 A CN201910191254 A CN 201910191254A CN 109706069 A CN109706069 A CN 109706069A
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- China
- Prior art keywords
- drug
- bonding agent
- culture dish
- ware body
- sensitive test
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Links
- 239000003814 drug Substances 0.000 title claims abstract description 61
- 229940079593 drug Drugs 0.000 title claims abstract description 54
- 238000012360 testing method Methods 0.000 title claims abstract description 44
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 11
- 239000007767 bonding agent Substances 0.000 claims abstract description 35
- 239000007788 liquid Substances 0.000 claims abstract description 8
- 239000000853 adhesive Substances 0.000 claims description 7
- 230000001070 adhesive effect Effects 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 6
- 230000000249 desinfective effect Effects 0.000 claims description 3
- 238000009792 diffusion process Methods 0.000 abstract description 4
- 241000894006 Bacteria Species 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000012633 leachable Substances 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940043263 traditional drug Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Abstract
The invention discloses a kind of culture dishes applied to drug sensitive test, it includes ware body, and ware body bottom is provided with the bonding agent without liquid permeable, and the bonding agent upper end is provided with drug susceptability test paper.The present invention provides a kind of culture dish and production method applied to drug sensitive test, can guarantee that the medicament contg on the drug susceptability test paper posted in advance is more accurate and can ensure that drug is unaffected in diffusion process.
Description
Technical field
The present invention relates to drug sensitive test field, specially a kind of culture dish and production method applied to drug sensitive test.
Background technique
Bacterium medicine is carried out using the drug susceptability test paper (generally being made of 1m filter paper, diameter 6-7mm) containing quantitative antibiotic
Object sensitization test is a kind of bacterial resistance test method of classics, is widely used in field of medical examination and related science research.
Traditional drug susceptability test paper manufacturing process is that the antibiotic of known concentration is added to the circular filter paper piece of certain amount, then will filter
Paper is pasted on the solid medium for being vaccinated with test bacterium, and this method is although simple and easy, but still there are problems that two, and one
When being by being added to the antibiotic of known concentration in the circular filter paper piece of certain amount, by the mean allocation of liquid, from
And the antibiotic content in per a piece of filter paper is estimated, but there are drugs to distribute non-uniform phenomenon；Second is that complete
Then person's hand paste that every a piece of drug sensitive test paper requires clinical manipulation passes through on the solid medium for being vaccinated with test bacterium
The natural diffuseness of drug forms drug concentration gradient, by culture seen whether bacterial growth come testing drug to bacterium whether
There is bacteriostasis, working efficiency is slower.
Occur recently as sensitive (abbreviation susceptibility) test products of commercial pharmaceutical, has had drug susceptability test paper is preparatory
The culture apparatus posted.But how to guarantee that the medicament contg on the drug susceptability test paper posted in advance is more accurate, how to guarantee medicine
Object is unaffected just at a key technology in diffusion process.
Summary of the invention
The present invention provides a kind of culture dish and production method applied to drug sensitive test, can guarantee the medicine posted in advance
Medicament contg on susceptability test paper is more accurate and can ensure that drug is unaffected in diffusion process.
In order to achieve the above object, the technical solution adopted by the present invention is that: a kind of culture dish applied to drug sensitive test, it is wrapped
Ware body is included, ware body bottom is provided with the bonding agent without liquid permeable, and the bonding agent upper end is provided with drug susceptability test paper.
Further, the aqueous adhesive sticker after the bonding agent is volatilized completely by volatile solvent is formed, bonding agent area
Domain diameter 0.5-2.5mm, and it is higher by ware body bottom upper surface 0.3-1.1mm.
Further, ware body bottom is provided with scale in bonding agent surrounding.
The production method that any one of the above is applied to the culture dish of drug sensitive test, step are that bonding agent is added dropwise first
In ware body bottom, it is made after the volatile solvent in bonding agent volatilizees completely without liquid permeable and there is good bonding
Property, filter paper central part is then bonded in bonding agent upper end, individually fills the drug containing actual concentrations after the completion of bonding
Filter paper is made to form drug susceptability test paper on each filter paper.
Further, it after filter paper being bonded in bonding agent upper end, needs to carry out disinfecting action before filling drug.
Beneficial effects of the present invention: filter paper is attached to culture dish bottom in advance, then the drug containing actual concentrations is individually added
Note can make the medicament contg high precision on every drug susceptability test paper, while by the way that drug susceptability test paper to be bonded on each scraps of paper
The fixed effect of drug susceptability test paper can be improved in the lesser adhesive sticker raised face of area and ensure that free diffusing is presented in drug in filter paper
State forms drug gradient.
Detailed description of the invention
Fig. 1 is schematic structural view of the invention.
Label character described in figure indicates are as follows: 1, ware body；2, bonding agent；3, drug susceptability test paper.
Specific embodiment
In order to make those skilled in the art more fully understand technical solution of the present invention, the present invention is retouched in detail below
State, the description of this part be only it is exemplary and explanatory, should not have any restriction effect to protection scope of the present invention.
It is of the invention the specific scheme is that a kind of culture dish applied to drug sensitive test, it includes ware body 1,1 bottom of ware body
Portion is provided with the bonding agent 2 without liquid permeable, and 2 upper end of bonding agent is provided with drug susceptability test paper 3.
Preferably, the aqueous adhesive sticker after the bonding agent 2 is volatilized completely by volatile solvent is formed, and SX088 can be used
Aqueous adhesive sticker does not have leachable ingredient after drying, belongs to simple physical surface bonding；2 regional diameter of bonding agent
0.5-2.5mm, area size can ensure that drug susceptability test paper 3 can firmly cement in 2 upper end of bonding agent without wasting water
Property adhesive sticker, 2 upper surface of bonding agent is higher by ware body bottom upper surface 0.3-1.1mm, so that 3 lower end surface of drug susceptability test paper and ware
There are some gaps in the upper surface of 1 bottom of body, facilitates drug diffusion.
Preferably, it observes for convenience, 1 bottom of ware body is provided with scale in 2 surrounding of bonding agent.
The production method that any one of the above is applied to the culture dish of drug sensitive test, step are that bonding agent is added dropwise first
In ware body bottom, it is made after the volatile solvent in bonding agent volatilizees completely without liquid permeable and there is good bonding
Property, filter paper central part is then bonded in bonding agent upper end, individually fills the drug containing actual concentrations after the completion of bonding
Filter paper is made to form drug susceptability test paper on each filter paper.
Preferably, it after filter paper being bonded in bonding agent upper end, needs to carry out disinfecting action before filling drug.
Specific embodiment: being added drop-wise to culture dish bottom for aqueous adhesive sticker, forms hemispherical projections after it is spontaneously dried
Bonding agent 2, make its to filter paper have very strong physical viscous；Then filter paper central part is placed in 2 lug boss of bonding agent
Point top and gently pressure is so that filter paper is cemented in 2 upper end of bonding agent, to form a suspension with stable adhesion fulcrum
Drug sensitive test paper, so that drug is smoothly spread in drug susceptability test paper 3 in experimentation.
A kind of culture dish and production method applied to drug sensitive test provided by the present invention has been carried out in detail above
Introduction, herein principle and implementation of the present invention are described, the explanation of above example is only intended to help
Understand method of the invention with its core concept；At the same time, for those skilled in the art, according to the thought of the present invention,
There will be changes in the specific implementation manner and application range, in conclusion the content of this specification should not be construed as pair
Limitation of the invention.
Claims (5)
1. a kind of culture dish applied to drug sensitive test, it includes ware body (1), which is characterized in that ware body (1) the bottom setting
There is the bonding agent (2) without liquid permeable, bonding agent (2) upper end is provided with drug susceptability test paper (3).
2. a kind of culture dish applied to drug sensitive test according to claim 1, which is characterized in that the bonding agent (2)
Aqueous adhesive sticker after being volatilized completely by volatile solvent is formed, bonding agent (2S) the regional diameter 0.5-2.5mm, and is higher by
Ware body bottom upper surface 0.3-1.1mm.
3. a kind of culture dish applied to drug sensitive test according to claim 1, which is characterized in that ware body (1) bottom
Portion is provided with scale in bonding agent (2) surrounding.
4. it is according to claim 1 to 3 any one be applied to the production method of the culture dish of drug sensitive test, feature exists
In, first by bonding agent (2) be added dropwise in ware body (1) bottom, make it not after the volatile solvent in bonding agent (2) volatilizees completely
Containing liquid permeable and there is good bonding, filter paper central part is then bonded in bonding agent upper end, it will after the completion of bonding
Drug containing actual concentrations is individually filled makes filter paper form drug susceptability test paper (3) on each filter paper.
5. a kind of production method of culture dish applied to drug sensitive test according to claim 4, which is characterized in that will filter
After paper is bonded in bonding agent upper end, need to carry out disinfecting action before filling drug.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910191254.9A CN109706069A (en) | 2019-03-13 | 2019-03-13 | A kind of culture dish and production method applied to drug sensitive test |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910191254.9A CN109706069A (en) | 2019-03-13 | 2019-03-13 | A kind of culture dish and production method applied to drug sensitive test |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109706069A true CN109706069A (en) | 2019-05-03 |
Family
ID=66266823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910191254.9A Pending CN109706069A (en) | 2019-03-13 | 2019-03-13 | A kind of culture dish and production method applied to drug sensitive test |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109706069A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2820872Y (en) * | 2005-06-16 | 2006-09-27 | 赵缜 | Culture dish for bacterial medicinal sensitive test |
| CN201049950Y (en) * | 2007-04-11 | 2008-04-23 | 湖北省农业科学院畜牧兽医研究所 | Antibiotic drug sensitive membrane |
| CN201850273U (en) * | 2010-05-29 | 2011-06-01 | 湖南省天骑医学新技术有限公司 | Culture box |
| US20120183991A1 (en) * | 2010-06-02 | 2012-07-19 | Jun Peng | Method for testing drug sensitivity of mycobacterium tuberculosis, application of indicator, and solid medium |
| CN202705364U (en) * | 2012-08-30 | 2013-01-30 | 黑龙江八一农垦大学 | Drug sensitive test quick-diagnosis culture dish |
| CN106645132A (en) * | 2017-02-09 | 2017-05-10 | 厦门信道生物技术有限公司 | Test paper for detecting lactose content of sample and preparation method of test paper |
| CN206876710U (en) * | 2017-05-10 | 2018-01-12 | 广东温氏食品集团股份有限公司 | A kind of susceptibility Test paper disk |
| CN207659444U (en) * | 2017-10-11 | 2018-07-27 | 泰山医学院 | Drug sensitive test culture dish |
-
2019
- 2019-03-13 CN CN201910191254.9A patent/CN109706069A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2820872Y (en) * | 2005-06-16 | 2006-09-27 | 赵缜 | Culture dish for bacterial medicinal sensitive test |
| CN201049950Y (en) * | 2007-04-11 | 2008-04-23 | 湖北省农业科学院畜牧兽医研究所 | Antibiotic drug sensitive membrane |
| CN201850273U (en) * | 2010-05-29 | 2011-06-01 | 湖南省天骑医学新技术有限公司 | Culture box |
| US20120183991A1 (en) * | 2010-06-02 | 2012-07-19 | Jun Peng | Method for testing drug sensitivity of mycobacterium tuberculosis, application of indicator, and solid medium |
| CN202705364U (en) * | 2012-08-30 | 2013-01-30 | 黑龙江八一农垦大学 | Drug sensitive test quick-diagnosis culture dish |
| CN106645132A (en) * | 2017-02-09 | 2017-05-10 | 厦门信道生物技术有限公司 | Test paper for detecting lactose content of sample and preparation method of test paper |
| CN206876710U (en) * | 2017-05-10 | 2018-01-12 | 广东温氏食品集团股份有限公司 | A kind of susceptibility Test paper disk |
| CN207659444U (en) * | 2017-10-11 | 2018-07-27 | 泰山医学院 | Drug sensitive test culture dish |
Non-Patent Citations (2)
| Title |
|---|
| 纪淑娟;浩淼;李东华;: "TTC法检测牛乳中抗生素快速检测试纸的制作", 食品工业科技, no. 03, pages 322 - 327 * |
| 谢保忠: "铭牌设计制作与粘接", 成都：四川科学技术出版社, pages: 330 - 333 * |
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