CN109701088A - A kind of hernia patch of antibacterial anti-inflammatory and preparation method thereof - Google Patents
A kind of hernia patch of antibacterial anti-inflammatory and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to medical material technical fields, and in particular to a kind of hernia patch of antibacterial anti-inflammatory and preparation method thereof.The hernia patch of antibacterial anti-inflammatory provided by the invention includes polypropylene substrate, and polypropylene substrate peripheral hardware sets the macromolecule membranous layer made of degradable high polymer material and biocompatible high molecular material composite solution.The hernia patch of antibacterial anti-inflammatory provided by the invention, light weight, good biocompatibility, implant no foreign body sensation, is not easy adhesion；And preparation method is simple, antibacterial and anti-inflammatory effects are good, and infection rate is low, to reduce the probability of complication, alleviate the pain and recurrence probability of patient, have stronger practical value and wide application prospect.
Description
Technical field
The invention belongs to medical material technical fields, and in particular to a kind of hernia patch of antibacterial anti-inflammatory and its preparation side
Method.
Background technique
Hernia disease, civil popular name hernia are that the tissue at the certain positions of human body or organ have left original position, pass through human body
Certain defects, gap and weakness enter another position, and generate the dysfunction of some internal organs.Occur most frequently the portion of hernia
Position is abdomen.Internal organs or nethike embrane leave original position through intraperitoneal normal or abnormal duct, crack and constitute abdominal internal hernia in abdomen,
It cannot be visual examination finding, such as hernia of foramen of Winslow, diaphragmatocele etc..Internal organs pass through the congenital or posteriority defect or thin of stomach wall in abdomen
Weak area is prominent to body surface, is being partially formed lump, referred to as abdominal external hernia.Abdominal external hernia is common far beyond abdominal internal hernia, in children to old age
All age brackets may all occur, and elderly men is the group of people at high risk of the disease.The cause of disease and the stomach wall weakness and abdominal pressure of abdominal external hernia
Increase related.Stomach wall weakness is usually geneogenous, it is also possible to be caused by acquired disposition, such as old and frail, muscular atrophy.Abdomen
The common situations increased are pressed to have chronic cough, constipation, dysuria and children cry etc..
Though hernia disease is not fatal disease, it can bring very big pain to patient, seriously affect quality of life, and can
There are many complication, can threat to life when serious.Operative treatment is treatment hernia disease most effective way, including traditional suture repair
With the big art formula of tension-free hernioplasty two for using patching material.Traditional repair mode has easy to recur, repairing time length, art
Afterwards the disadvantages of pain.
Tension-free Hernioplasty be the postoperative pain for avoiding traditional herniorrhaphy come repairing hernia notch with sticking patch,
Disadvantage easy to recur.Currently used hernia patch is polyester patches, polypropylene substrate and expanded polytetrafluoroethylsealing sticking patch.In mistake
In 50 years gone, the external section field of polypropylene substrate produces tremendous influence, and countless patients are because having it and life is able to
Continue, many surgery knotty problems are solved because of its application, it has been found to be most popular in current surgical field
Implant.Nevertheless, there is also some problems in the application for polypropylene substrate.
Chinese patent application CN103263693A disclose a kind of immobilized antimicrobial drug hernia repair patch preparation method and
Purposes, a kind of immobilized antimicrobial drug hernia repair patch with slow control-release function of the disclosure of the invention, preparation recipe object, Gao Jufa
And purposes.More particularly to by antibacterial material and macromolecule patching material, pass through dip coating or spray coating method or coating legal system
Standby immobilized antimicrobial drug hernia repair patch and this hernia repair sticking patch answering in terms of causing bacterium infection after treating herniorrhaphy
With.Although the immobilized antimicrobial drug hernia repair patch of the invention has good biocompatibility, preparation is simple, its mechanics
Performance is poor, and anti-microbial property is undesirable, and implanting has apparent foreign body sensation, and the effect of antibacterial anti-inflammatory is poor, and wound is easy to produce
Raw infection.
Chinese patent application CN102205151A discloses a kind of immobilized antibacterials hernia patch and preparation method thereof, institute
The hernia patch stated includes drug bearing microsphere, sticking patch and proppant, by drug sandwich between sticking patch layer and film layer, although should
The effect of invention antibacterial anti-inflammatory is preferable, but Antibiogics usage therein remains antibiotic, such as first vancomycin, through the ages
Mycin or methicillin etc., thus can not still solve the problems, such as drug resistance；And patch and the adhesion situation of internal organ are serious,
Preparation process is complicated, it is difficult to be promoted.
In conclusion hernia patch in the prior art still has poor mechanical property, implants and have foreign body sensation, and
The problems such as patch and the adhesion situation of internal organ are serious, and preparation process is complicated, and antibacterial anti-inflammatory performance is poor.
Summary of the invention
In order to solve the problems in the existing technology, the purpose of the present invention is to provide a kind of repairings of the hernia of antibacterial anti-inflammatory
Piece and preparation method thereof.The hernia patch of antibacterial anti-inflammatory provided by the invention, light weight, good biocompatibility, implant nothing
Foreign body sensation is not easy adhesion；And preparation method is simple, antibacterial and anti-inflammatory effects are good, and infection rate is low.
The technical scheme is that
A kind of hernia patch of antibacterial anti-inflammatory, which is characterized in that including polypropylene substrate, polypropylene substrate peripheral hardware is set by can
Macromolecule membranous layer made of degraded macromolecular material and biocompatible high molecular material composite solution.
Further, the polypropylene substrate uses no-station pole canopy polypropylene substrate, is netted braided fabric.
Further, the degradable high polymer material is polylactic acid.
Further, degradable high polymer material and quality that the macromolecule membranous layer is 65-88% by mass percent
Percentage is made of the biocompatible polymer material composite solution of 12-35%.
Further, degradable high polymer material and quality percentage that the macromolecule membranous layer is 76% by mass percent
Number is made of 24% biocompatible polymer material composite solution.
Further, the biocompatible high molecular material composite solution is pressed by chitosan, sodium alginate and antibacterial peptide
Mass ratio 7-18:1-5:2-5 is made.
Further, the composite solution of the biocompatible high molecular material is by chitosan, sodium alginate and antibacterial peptide
12:4:7 is made in mass ratio.
Further, the preparation method of the biocompatible high molecular material composite solution, comprising the following steps:
S1 is by molecular weight 3.7-5.3 × 105Chitosan be dissolved in concentration be 0.3-0.5mol/L citric acid solution in,
The mass concentration 15-24% for making chitosan in solution, stirs and evenly mixs under confined conditions, and ultrasonic deaeration obtains chitosan solution；
S2 separately weighs sodium alginate and is added in distilled water, and the additional amount of distilled water is 5 times of sodium alginate quality, stirs evenly,
Make it after completely dissolution, chitosan solution obtained by the antibacterial peptide and step S1 that molecular weight is 3500-6500 be added, stirs evenly,
To obtain the final product.
In addition, the present invention also provides a kind of preparation methods of the hernia patch of antibacterial anti-inflammatory, comprising the following steps:
It is 1-5 × 10 that S1, which takes molecular weight,5Degradable high polymer material be dissolved in high molecular material solvent, confined condition
Lower stirring makes it completely dissolved, and ultrasonic deaeration obtains degradable macromolecule solution；
S2 mixes biocompatible high molecular material composite solution with degradable macromolecule solution prepared by step S1
It is even, it is poured on plate, after evaporation volatilization, secure satisfactory grades sub- film layer；
S3 is opposite by polypropylene substrate and macromolecule membranous layer, hot pressing be integrally formed to get.
Further, high molecular material solvent is one of acetone, ethyl acetate, chloroform in the step S1.
In a kind of hernia patch of antibacterial anti-inflammatory provided by the invention, polypropylene substrate is monolithic reticular structure, Yi Beijie
Form tissue infiltration, implant no foreign body sensation.Polylactic acid have good degradation property, into vivo after can gradually degrade, with small
The form of molecule enters body metabolism, securely and reliably.
In a kind of hernia patch of antibacterial anti-inflammatory provided by the invention, the biocompatible polymer material composite solution by
Chitosan, sodium alginate and antibacterial peptide are formed according to certain weight ratio, and wherein chitosan has good film forming and biofacies
Capacitive can inhibit fibroblast to grow up, and promote epidermal growth, promote Wound healing.Antibacterial peptide has broad-spectrum bactericidal action,
Including especially having apparent inhibitory or killing effect to antibody-resistant bacterium to gram-positive bacteria and Gram-negative bacteria.The alginic acid of addition
Sodium can make sticking patch form hydrophilic form of hydrogels, can prevent hernia patch and internal organs adhesion, and the macromolecule formed
Network system property is soft, but still is able to maintain certain shape, so that the mechanical property of hernia patch increases.The present invention
Middle each component synergistic effect, the effect of antibacterial anti-inflammatory significantly improve, and effectively prevent the adhesion of internal organ and hernia patch, reduce
The occurrence probability of complication.
Compared with prior art, the hernia patch of antibacterial anti-inflammatory provided by the invention has the advantage that
(1) the hernia patch preparation method of antibacterial anti-inflammatory provided by the invention is simple, and good biocompatibility, implant nothing
Foreign body sensation, is not easy and visceral adhesion alleviates the pain and recurrence probability of patient, have to reduce the probability of complication
Stronger practical value.
(2) it is added to biocompatible polymer material composite solution in the hernia patch of antibacterial anti-inflammatory provided by the invention,
The healing that wound can be effectively facilitated improves the effect of the antibacterial anti-inflammatory of hernia patch, using hernia patch of the present invention
Come when carrying out the treatment of hernia disease, without preventing to infect using antibiotic to systemic, safety is without side-effects, there is wide answer
Use prospect.
Specific embodiment
The following describes the present invention further through the description of specific embodiments, but it is to limit of the invention that this, which is not,
System, those skilled in the art's basic thought according to the present invention can make various modifications or improvements, but without departing from this
The basic thought of invention, it is within the scope of the present invention.
Antibacterial peptide is purchased from Chengdu Jia Ye Biotechnology Co., Ltd.
A kind of hernia patch of the antibacterial anti-inflammatory of embodiment 1
The hernia patch of the antibacterial anti-inflammatory, including polypropylene substrate, polypropylene substrate peripheral hardware are set by polylactic acid and biology
Macromolecule membranous layer made of compatible high molecular material composite solution.
The polypropylene substrate uses no-station pole canopy polypropylene substrate, is netted braided fabric.
The bio-compatible that the polylactic acid and mass percent that the macromolecule membranous layer is 65% by mass percent are 35%
High molecular material composite solution is made.
The biocompatible high molecular material composite solution is by chitosan, sodium alginate and antibacterial peptide by weight 7:5:
5 are made.
The preparation method of the biocompatible high molecular material composite solution, comprising the following steps:
S1 is by molecular weight 3.7 × 105Chitosan be dissolved in concentration be 0.3mol/L citric acid solution in, make in solution
The mass concentration of chitosan is 15%, is stirred and evenly mixed under confined conditions, ultrasonic deaeration obtains chitosan solution；
S2 separately weighs sodium alginate and is added in distilled water, and the additional amount of distilled water is 5 times of sodium alginate quality, stirs evenly,
Make it after completely dissolution, chitosan solution obtained by antibacterial peptide and step S1 that molecular weight is 3500 be added, stir evenly to get.
The preparation method of the hernia patch of the antibacterial anti-inflammatory, comprising the following steps:
It is 1 × 10 that S1, which takes molecular weight,5Polylactic acid be dissolved in ethyl acetate solution, under confined conditions stirring make its completely
Dissolution, ultrasonic deaeration obtain PLA solution；
Biocompatible high molecular material composite solution is uniformly mixed by S2 with the step S1 PLA solution prepared, is toppled over
In on plate, after evaporation volatilization, secure satisfactory grades sub- film layer；
S3 is opposite by polypropylene substrate and macromolecule membranous layer, hot pressing be integrally formed to get.
A kind of hernia patch of the antibacterial anti-inflammatory of embodiment 2
The hernia patch of the antibacterial anti-inflammatory, including polypropylene substrate, polypropylene substrate peripheral hardware are set by polylactic acid and biology
Macromolecule membranous layer made of compatible high molecular material composite solution.
The polypropylene substrate uses no-station pole canopy polypropylene substrate, is netted braided fabric.
The bio-compatible that the polylactic acid and mass percent that the macromolecule membranous layer is 76% by mass percent are 24%
High molecular material composite solution is made.
The composite solution of the biocompatible high molecular material by chitosan, sodium alginate and antibacterial peptide by weight
12:4:3 is made.
The preparation method of the biocompatible high molecular material composite solution, comprising the following steps:
S1 is by molecular weight 4.6 × 105Chitosan be dissolved in concentration be 0.4mol/L citric acid solution in, make in solution
The mass concentration of chitosan is 20%, is stirred and evenly mixed under confined conditions, ultrasonic deaeration obtains chitosan solution；
S2 separately weighs sodium alginate and is added in distilled water, and the additional amount of distilled water is 5 times of sodium alginate quality, stirs evenly,
Make it after completely dissolution, chitosan solution obtained by antibacterial peptide and step S1 that molecular weight is 5200 be added, stir evenly to get.
In addition, the present invention also provides a kind of preparation methods of the hernia patch of antibacterial anti-inflammatory, comprising the following steps:
It is 3 × 10 that S1, which takes molecular weight,5Polylactic acid be dissolved in acetone soln, under confined conditions stirring make its completely it is molten
Solution, ultrasonic deaeration obtain PLA solution；
Biocompatible high molecular material composite solution is uniformly mixed by S2 with the step S1 PLA solution prepared, is toppled over
In on plate, after evaporation volatilization, secure satisfactory grades sub- film layer；
S3 is opposite by polypropylene substrate and macromolecule membranous layer, hot pressing be integrally formed to get.
A kind of hernia patch of the antibacterial anti-inflammatory of embodiment 3
The hernia patch of the antibacterial anti-inflammatory, including polypropylene substrate, polypropylene substrate peripheral hardware are set by polylactic acid and biology
Macromolecule membranous layer made of compatible high molecular material composite solution.
The polypropylene substrate uses no-station pole canopy polypropylene substrate, is netted braided fabric.
The bio-compatible that the polylactic acid and mass percent that the macromolecule membranous layer is 88% by mass percent are 12%
High molecular material composite solution is made.
The biocompatible high molecular material composite solution is by chitosan, sodium alginate and antibacterial peptide by weight 18:
1:2 is made.
The preparation method of the biocompatible high molecular material composite solution, comprising the following steps:
S1 is by molecular weight 5.3 × 105Chitosan be dissolved in concentration be 0.5mol/L citric acid solution in, make in solution
The mass concentration of chitosan is 24%, is stirred and evenly mixed under confined conditions, ultrasonic deaeration obtains chitosan solution；
S2 separately weighs sodium alginate and is added in distilled water, and the additional amount of distilled water is 5 times of sodium alginate quality, stirs evenly,
Make it after completely dissolution, chitosan solution obtained by antibacterial peptide and step S1 that molecular weight is 6500 be added, stir evenly to get.
In addition, the present invention also provides a kind of preparation methods of the hernia patch of antibacterial anti-inflammatory, comprising the following steps:
It is 5 × 10 that S1, which takes molecular weight,5Polylactic acid be dissolved in chloroform soln, under confined conditions stirring make its completely
Dissolution, ultrasonic deaeration obtain PLA solution；
Biocompatible high molecular material composite solution is uniformly mixed by S2 with the step S1 PLA solution prepared, is toppled over
In on plate, after evaporation volatilization, secure satisfactory grades sub- film layer；
S3 is opposite by polypropylene substrate and macromolecule membranous layer, hot pressing be integrally formed to get.
A kind of hernia patch of the antibacterial anti-inflammatory of comparative example 1
The hernia patch of the antibacterial anti-inflammatory, including polypropylene substrate, polypropylene substrate peripheral hardware are set by polylactic acid and biology
Macromolecule membranous layer made of compatible high molecular material composite solution.
The polypropylene substrate uses no-station pole canopy polypropylene substrate, is netted braided fabric.
The bio-compatible that the polylactic acid and mass percent that the macromolecule membranous layer is 76% by mass percent are 24%
High molecular material composite solution is made.
The composite solution of the biocompatible high molecular material is made of chitosan and sodium alginate by weight 12:4.
The preparation method of the biocompatible high molecular material composite solution is similar to Example 2.
The preparation method of the hernia patch of the antibacterial anti-inflammatory is similar to Example 2.
The difference from example 2 is that the high molecular material composite solution is not added with antibacterial peptide.
A kind of hernia patch of the antibacterial anti-inflammatory of comparative example 2
The hernia patch of the antibacterial anti-inflammatory, including polypropylene substrate, polypropylene substrate peripheral hardware are set by polylactic acid and biology
Macromolecule membranous layer made of compatible high molecular material composite solution.
The polypropylene substrate uses no-station pole canopy polypropylene substrate, is netted braided fabric.
The bio-compatible that the polylactic acid and mass percent that the macromolecule membranous layer is 76% by mass percent are 24%
High molecular material composite solution is made.
The composite solution of the biocompatible high molecular material is made of chitosan and antibacterial peptide by weight 12:3.
The preparation method of the biocompatible high molecular material composite solution is similar to Example 2.
The preparation method of the hernia patch of the antibacterial anti-inflammatory is similar to Example 2.
The difference from example 2 is that the high molecular material composite solution is not added with sodium alginate.
A kind of hernia patch of the antibacterial anti-inflammatory of comparative example 3
The hernia patch of the antibacterial anti-inflammatory, including polypropylene substrate, poly- polypropylene substrate peripheral hardware are set by polylactic acid and life
Macromolecule membranous layer made of the compatible high molecular material composite solution of object.
The polypropylene substrate uses no-station pole canopy polypropylene substrate, is netted braided fabric.
The bio-compatible that the polylactic acid and mass percent that the macromolecule membranous layer is 76% by mass percent are 24%
High molecular material composite solution is made.
The composite solution of the biocompatible high molecular material is by chitosan, sodium alginate and antibacterial peptide by weight 1:
1:1 is made.
The preparation method of the biocompatible high molecular material composite solution is similar to Example 2.
The preparation method of the hernia patch of the antibacterial anti-inflammatory is similar to Example 2.
The difference from example 2 is that the high molecular material composite solution is pressed by chitosan, sodium alginate and antibacterial peptide
Weight ratio 1:1:1 is made.
Test example one, anti-blocking properties test
1. test material: embodiment 2, the hernia patch of comparative example 1-3 preparation.
2. test method: take 30 new zealand white rabbits, every during operation weight between 2.5-3.6Kg.By its fiber crops
It is liquor-saturated, in the full depth muscle layer of left abdomen excision 20mm × 20mm, then (with the simple propene polymer patch of 30mm × 30mm
Commercialized product, kind to release, 6), the hernia patch (each 6) for preparing of the hernia patch (6) for preparing of embodiment 2 and comparative example 1-3
It is repaired, sticking patch is fixed on stomach wall with 4-0prolene suture, is sewed up a wound.3 months after operation implements experimental animal
It is euthanized and assesses its anti-blocking properties, including adhesion area, adhesion severity and adhesion incidence.
Adhesion grading standard are as follows: 0 point-without adhesion；1 point-tissue adhension is i.e. separable with gravity；2 points-tissue
Adherency need to use blunt separation；3 points-tissue adhension need to be separated with sharp property.
Adhesion face integral grade standard: 0 point-do not have adhesion；1 point -≤25% surface has adhesion, averagely 12.5%；2
Point-surface 26-50% has an adhesion, average 37.5%；The surface 3 points -51-75% has adhesion, averagely 63%；4 points->=
76% surface has adhesion, averagely 88%.Vertical high-definition camera carried out to the sticking patch with adhesion, and with Photoshop with
SiconImage software is handled, to carry out the calculating of adhesion area.Adhesion incidence be the size of animal that sticks together with
With the ratio percentage of group total quantity.
3. test result
Test result is as shown in table 1.
Adhesion result after the repairing of table 1
As shown in Table 1, the antibacterial hernia patch of the anti-inflammatory that prepared by the embodiment of the present invention 2 prevents abdominal visceral browser intraperitoneal
It is very good with the effect of sticking patch adhesion, it is entirely avoided the generation of adhesion phenomenon.And the test knot of embodiment 2 and comparative example 1-3
Fruit shows that when changing the constituent and ratio of biocompatible polymer material composite solution, the hernia of comparative example 1-3 preparation is repaired
Sticking patch is in intraperitoneal the case where generating with internal organs adhesion.
Test example two, anti-microbial property test
1. test material: the hernia patch of embodiment 1-3, comparative example 1-3 preparation.
2. subjects: Escherichia coli, Candida albicans, staphylococcus aureus.
3. test method: antibacterial experiment: the embodiment 1-3 and comparative example 1-3 50mm × 50mm hernia patch prepared being set
In sterile conical flask, it is separately added into 70mL phosphate buffer (0.03molL-1) and 5mL bacterium solution, culture medium is penetrated into liquid
In after, 37 DEG C culture for 24 hours after, carry out bacterium colony counting.
Bacteriostasis rate calculation formula: X=(A-B)/A × 100%, wherein X is bacteriostasis rate, and A is average colony before sample vibrates
Number, B are average colony number after test agent oscillation.
4. test result
Test result is as shown in table 2.
The hernia patch antibacterial tests result of 2 antibacterial anti-inflammatory of table
By the anti-microbial property test of table 2 as the result is shown it is found that a kind of hernia of antibacterial anti-inflammatory of 1-3 of embodiment of the present invention preparation
For patch to Escherichia coli, the inhibitory effect of Candida albicans and Staphylococcus aureus is significant, antibacterial after contact 24 hours
Rate is 97% or more, and wherein the bacteriostasis rate highest of embodiment 2 is highly preferred embodiment of the present invention 98% or more.Comparison
The hernia patch fungistatic effect of example 1-3 preparation is relatively weak, and comparative example 1-3 and the comparing result of embodiment show the present invention
The biocompatible polymer material composite solution each component added in the hernia patch of the antibacterial anti-inflammatory of preparation is synergistic, has
Wide spectrum and potent anti-microbial property can effectively prevent wound by bacterium infection, and bacteriostasis rate is high.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (10)
1. a kind of hernia patch of antibacterial anti-inflammatory, which is characterized in that including polypropylene substrate, polypropylene substrate peripheral hardware is set by that can drop
Solve macromolecule membranous layer made of high molecular material and biocompatible high molecular material composite solution.
2. the hernia patch of antibacterial anti-inflammatory as described in claim 1, which is characterized in that the polypropylene substrate uses no-station pole canopy
Polypropylene substrate is netted braided fabric.
3. the hernia patch of antibacterial anti-inflammatory as described in claim 1, which is characterized in that the degradable high polymer material is poly-
Lactic acid.
4. the hernia patch of antibacterial anti-inflammatory as described in claim 1, which is characterized in that the macromolecule membranous layer is by quality percentage
The biocompatible polymer material that the degradable high polymer material and mass percent that number is 65-88% are 12-35% is compound molten
Liquid is made.
5. the hernia patch of antibacterial anti-inflammatory as claimed in claim 4, which is characterized in that the macromolecule membranous layer is by quality percentage
Number is made of 76% degradable high polymer material and mass percent of 24% biocompatible polymer material composite solution.
6. the hernia patch of antibacterial anti-inflammatory as described in claim 1, which is characterized in that the biocompatible high molecular material
Composite solution is made of chitosan, sodium alginate and antibacterial peptide 7-18:1-5:2-5 in mass ratio.
7. the hernia patch of antibacterial anti-inflammatory as claimed in claim 6, which is characterized in that the biocompatible high molecular material
Composite solution be made of chitosan, sodium alginate and antibacterial peptide 12:4:3 in mass ratio.
8. the hernia patch of antibacterial anti-inflammatory as claimed in claim 6, which is characterized in that the biocompatible high molecular material is multiple
Close the preparation method of solution, comprising the following steps:
S1 is by molecular weight 3.7-5.3 × 105Chitosan be dissolved in concentration be 0.3-0.5mol/L citric acid solution in, make molten
The mass concentration of chitosan is 15-24% in liquid, is stirred and evenly mixed under confined conditions, ultrasonic deaeration obtains chitosan solution；
S2 separately weighs sodium alginate and is added in distilled water, and the additional amount of distilled water is 5 times of sodium alginate quality, stirs evenly, makes it
After completely dissolution, it is chitosan solution obtained by the antibacterial peptide and step S1 of 3500-6500 that molecular weight, which is added, stir evenly to get.
9. a kind of preparation method of such as hernia patch of the described in any item antibacterial anti-inflammatory of claim 1-8, which is characterized in that packet
Include following steps:
It is 1-5 × 10 that S1, which takes molecular weight,5Degradable high polymer material be dissolved in high molecular material solvent, stir under confined conditions
It mixes and makes it completely dissolved, ultrasonic deaeration obtains degradable macromolecule solution；
Biocompatible high molecular material composite solution is uniformly mixed by S2 with degradable macromolecule solution prepared by step S1, is inclined
In on plate, after evaporation volatilization, secure satisfactory grades sub- film layer；
S3 is opposite by polypropylene substrate and macromolecule membranous layer, hot pressing be integrally formed to get.
10. the preparation method of the hernia patch of antibacterial anti-inflammatory according to claim 9, which is characterized in that the step S1
Middle high molecular material solvent is one or more of acetone, ethyl acetate, chloroform.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114366850A (en) * | 2022-01-19 | 2022-04-19 | 复旦大学附属华山医院 | Artificial rotator cuff patch based on drug-loaded silk protein and preparation method thereof |
| CN114681684A (en) * | 2020-12-30 | 2022-07-01 | 宁波新跃医疗科技股份有限公司 | Antibacterial hernia repair patch and preparation method thereof |
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