CN105194740A - Postoperation anti-adhesion hydrogel and preparing method thereof - Google Patents
Postoperation anti-adhesion hydrogel and preparing method thereof Download PDFInfo
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- CN105194740A CN105194740A CN201510598128.7A CN201510598128A CN105194740A CN 105194740 A CN105194740 A CN 105194740A CN 201510598128 A CN201510598128 A CN 201510598128A CN 105194740 A CN105194740 A CN 105194740A
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- 238000000034 method Methods 0.000 title claims abstract description 8
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- 229920001661 Chitosan Polymers 0.000 claims abstract description 52
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 claims abstract description 52
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 51
- 239000000661 sodium alginate Substances 0.000 claims abstract description 51
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 51
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 50
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- 239000000843 powder Substances 0.000 claims abstract description 33
- 229910001870 ammonium persulfate Inorganic materials 0.000 claims abstract description 26
- 239000000463 material Substances 0.000 claims abstract description 22
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims abstract description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 49
- 230000003405 preventing effect Effects 0.000 claims description 32
- 239000000243 solution Substances 0.000 claims description 31
- 239000011259 mixed solution Substances 0.000 claims description 22
- 239000003431 cross linking reagent Substances 0.000 claims description 20
- 239000011812 mixed powder Substances 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 claims description 12
- 239000003054 catalyst Substances 0.000 claims description 9
- 239000002131 composite material Substances 0.000 claims description 9
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 238000004132 cross linking Methods 0.000 claims description 8
- 150000001768 cations Chemical class 0.000 claims description 7
- 239000011521 glass Substances 0.000 claims description 7
- 230000006698 induction Effects 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
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- 238000003381 deacetylation reaction Methods 0.000 claims description 4
- 206010052428 Wound Diseases 0.000 abstract description 11
- 208000027418 Wounds and injury Diseases 0.000 abstract description 11
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 abstract description 5
- 230000002265 prevention Effects 0.000 abstract description 4
- 239000012620 biological material Substances 0.000 abstract description 2
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- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
The invention discloses postoperation anti-adhesion hydrogel and a preparing method thereof. The hydrogel is prepared from sodium alginate powder, chitosan powder, acrylamide monomers, N,N'-methylene bisacrylamide, calcium sulfate, ammonium persulfate and N,N,N',N'-tetramethylethylenediamine. The preparing method of the high-strength high-tenacity chitosan and sodium alginate compound hydrogel is easy to operate, parameters are controllable, the materials are easy to obtain, and the solvent is nontoxic or low in toxicity and safe to treat and use; the method integrates advantages of the two natural biological materials, and the requirement for postoperation adhesion prevention of patients and the requirement for nursing care and treatment of medical workers can be met well. The hydrogel is soft, can be attached to the skin easily, has good flexibility and can effectively prevent wound surface adhesion and be degraded and absorbed, secondary trauma is avoided, and the hydrogel is expected to become a novel postoperation anti-adhesion material.
Description
Technical field
The invention belongs to biology medical material technical field, relate to a kind of medical aquogel and preparation method thereof with post-operation adhesion preventing, antibacterial, hemostasis, more creation.
Background technology
Postoperative intestinal adhesion be have history of operation since one of important difficult medical problem urgently to be resolved hurrily both at home and abroad.In the operation that surgical field is carried out, the overwhelming majority relates to the problem preventing adhesion between tissue, and adhesion occurs not only can bring misery to patient but also need face the operation expense of great number, therefore develops Film with Preventing Adhesion material very urgent.Under normal circumstances, the fabric strip of connective tissue can not stick together with adjacent organ or tissue, but after underwent operative, because of operation wound, wound ischemia, foreign body exist, hemorrhage and expose wound surface and bacteriological infection and occur the coherent anomalous structure of connective fiber band and adjacent tissue or organ, be also in the common clinical picture-adhesion of surgical field.Postoperative intestinal adhesion can cause serious complication, as abdominal part, pelvic cavity etc. all can cause adhesive ileus, and the female infertility causing recurrent nerve injury after thyroid operation and cause because of pelvic tissue adhesion.Wherein, the patient doing abdominal operation about has 93% to have adhesion to occur, and the incidence rate living through patient's adhesion of gynecilogical operation is up to 40% being caused by adhesion in 97%(infertile women).Therefore, the incidence rate that how effective prevention of postoperative adhesion reduces clinical complication is important topic urgently to be resolved hurrily in clinical treatment.
At present apply more Prevention of postsurgical adhesion material clinically and mainly contain gel-like and polylactic acid-based two kinds: gel-like (hyaluronate sodium and chitosan gel rubber) in vivo can biodegradation, but degradation rate is too fast, in body, the too short and gel of retention time easily runs off, and makes preventing adhesiving effect not good enough; Polylactic acid-based (Poly-L-lactic acid, PDLLA etc.) applies maximum materials in biomedical engineering at present, also be simultaneously by one of several biomaterials few in number of U.S. FDA certification, but it can produce acid degradation products in degradation process, acidic materials play autocatalysis on the one hand, accelerate the degraded of parent, decrease retention time in body, reduce preventing adhesiving effect, a large amount of acid product is piled up on the other hand, may produce again non-infectious inflammation and cause certain stimulation to tissue and organ.Sodium alginate has good biocompatibility, biodegradability, the biological property such as hemostatic, and the report at present as adherence preventing material is less.Desirable adherence preventing material should have good biocompatibility, suitable tissue adherence (not needing to sew up), and the complete wound coverage surface of energy also has retention time in enough bodies; Can degraded and absorbed and do not need second operation to be taken out; Play the effect effectively preventing Adhesion formation, the normal healing processes of wound can not be affected again; Take into account hemostasis, antibacterial, short effect more have certain mechanical strength and toughness, so that by material implantation etc. in operation simultaneously.
In existing patent, CN103224679A discloses a kind of Chitosan polyacrylamide hydrogel base material, by solution compositions such as acrylamide, methylene diacrylamide, Ammonium persulfate., tetramethylethylenediamine, chitosans, obtain the hydrogel of different hardness and there is free of toxic effects, reducing the complexity of research cyto-mechanics.CN104558420A discloses a kind of temperature and pH-sensitivity carboxymethyl chitosan hydrogel, respectively with Ammonium persulfate., N, N, N ', N '-tetramethylethylenediamine and N, N '-methylene-bisacrylamide is initiator, promoter and cross-linking agent, obtained by cross-linking reaction, its biocompatibility is increased, expands its range of application.CN103396562A discloses a kind of preparation method based on sodium alginate-acrylamide gel, with acrylamide monomer, methylene diacrylamide for cross-linking agent, and Ammonium persulfate. and N, N, N ', N '-tetramethylethylenediamine is catalyst, obtains the Sodium Alginate Hydrogel Films of high strength, high tenacity.Li etc. preparation alginate-polyacrylamide hydrophilic gel can possess high strength and toughness simultaneously, adopt acrylamide, N, N '-methylene-bisacrylamide, CaSO
42H
2o and CaCl
2as cross-linking agent, Ammonium persulfate. and N, N, N ', N '-tetramethylethylenediamine is the hydrogel that catalyst obtains, and has good application prospect in bio-medical field.
Summary of the invention
The preparation method of the comprehensive current material of the present invention and raising hydrogel performance, a kind of post-operation adhesion preventing hydrogel and preparation method thereof is provided, chitosan and sodium alginate are carried out the hydrogel that compound prepares high strength and high tenacity, is expected to become and there is antibacterial, hemostasis, absorptive tissue transudate, keeps the post-operation adhesion preventing material of the moistening and effective wound healing of wound surface.
The object of the invention is to be achieved through the following technical solutions:
A kind of post-operation adhesion preventing hydrogel, by sodium alginate powder, Chitosan powder, acrylamide monomer, N, N '-methylene-bisacrylamide, calcium sulfate, Ammonium Persulfate 98.5 and N, N, N ' N '-tetramethylethylenediamine is prepared from, wherein, the mass ratio of Chitosan powder and sodium alginate powder is 8-10:1-3, the mass ratio of chitosan and sodium alginate mixed-powder and acrylamide monomer is 1:3-20, N, the mass ratio of N '-methylene bisacrylamide acyl and acrylamide monomer is 0.0006-0.0025, the mass ratio of calcium sulfate and acrylamide monomer is 0.016, the mass ratio of Ammonium persulfate. and acrylamide monomer is 0.006-0.03, N, N, N ', the mass ratio of N '-tetramethylethylenediamine and acrylamide monomer is 0.0025-0.0055.
A preparation method for above-mentioned post-operation adhesion preventing hydrogel, concrete steps are as follows:
The first step: at ambient temperature chitosan and sodium alginate mixed-powder are dissolved in 0.5-2w/v% aqueous acetic acid, make it fully dissolve by magnetic stirrer, obtain the mixed solution of stable homogeneous;
Second step: add acrylamide monomer in the mixed solution obtained to the first step successively, mixed solution is at room temperature stirred 10-48h until solubilize is even; Then progressively add N, N '-methylene-bisacrylamide, calcium sulfate as cross-linking agent, Ammonium Persulfate 98.5 and N, N, N ' N '-tetramethylethylenediamine as catalyst, at room temperature continue to stir 0.5-3h, the solution for preparing at room temperature left standstill 0.5-2h deaeration; The solution left standstill is poured in glass mold, at room temperature leaves standstill 6-10h and guarantee its complete reaction, obtain hydrogel.
3rd step: the hydrogel prepared by second step is fully immersed in the CaCl that concentration is 0.05-1.5M
23-36h in solution, cation diffuses in hydrogel network structure, and induction chitosan and sodium alginate cross-linking, prepare the composite aquogel adherence preventing material of high-strength and high-ductility.
Preferably, in described first step solution, the concentration of chitosan and sodium alginate mixed-powder is 0.5-2%(w/w).
Preferably, in the described first step, chitosan is off-white powder, deacetylation >70%, and rank is medical grade, and sodium alginate is white powder, and rank is medical grade.
Compared with prior art, the invention has the beneficial effects as follows:
1, the invention provides the preparation method of a kind of high-strength, high tenacity chitosan and sodium alginate composite hydrogel, this preparation method is easy to operation, and parameter is controlled, and material is easy to get, nontoxic solvent or low toxicity, process and use safety; The method has assembled the advantage of two kinds of natural biologic materials, can be good at the requirement meeting prevention patient post-operation adhesion preventing, and the nursing for treating demand of medical personnel.
2, the chitosan prepared of the method and sodium alginate composite hydrogel have high-strength and high-ductility feature, compensate for the deficiency of hydrogel in the past, chitosan itself has broad-spectrum antiseptic, hemostasis, absorption transudate, more wound, and good biocompatibility and biodegradability, sodium alginate, when contacting with wound exudate, prepares the sodium alginate of solubility by ion exchange, discharge calcium ion in wound simultaneously, induced platelet activates, and can accelerate wound healing.
3, this hydrogel softness is easy to and skin attachement, has good pliability, can effectively prevent wound surface adhesion, and can be degraded and absorbed, avoid the generation of secondary insult, is expected to become novel post-operation adhesion preventing material.
Detailed description of the invention
Below in conjunction with embodiment, technical scheme of the present invention is further described; but be not limited thereto; everyly technical solution of the present invention modified or equivalent to replace, and not departing from the spirit and scope of technical solution of the present invention, all should be encompassed in protection scope of the present invention.
Embodiment 1
(1) a certain amount of glacial acetic acid is taken respectively with electronic balance, be made into the aqueous acetic acid that mass fraction is 0.5w/v%, taking certain mass CS/SA(9/1) powder joins in aqueous acetic acid, be configured to the mixed solution of 0.5w/v%, make it fully dissolve by magnetic stirrer, obtain the solution of stable homogeneous.
(2) in above-mentioned mixed solution, add acrylamide monomer successively, mixed solution is at room temperature stirred 2d until solubilize is even; Then progressively add N, N '-methylene bisacrylamide acyl, calcium sulfate as cross-linking agent, Ammonium Persulfate 98.5 and N, N, N ' N '-tetramethylethylenediamine as catalyst, at room temperature continue to stir 1h, the solution for preparing at room temperature left standstill 0.5-2h deaeration; The solution left standstill is poured in glass mold, at room temperature leaves standstill and guarantee its complete reaction a whole night.Wherein: the mass ratio of chitosan and sodium alginate mixed-powder and acrylamide monomer is 1:5, N, the mass ratio of N '-methylene bisacrylamide acyl cross-linking agent and acrylamide monomer is 0.0006, the mass ratio of calcium sulfate and acrylamide monomer is 0.016, the mass ratio of Ammonium persulfate. and acrylamide monomer is 0.006, N, N, N ', N ' mass ratio of-tetramethylethylenediamine and acrylamide monomer is 0.0025.
(3) hydrogel prepared is fully immersed in the CaCl that concentration is 0.5M
212h in solution, cation diffuses in hydrogel network structure, induction chitosan and sodium alginate cross-linking, produces the composite aquogel adherence preventing material of high-strength and high-ductility.
Carry out extension test to obtained hydrogel, obtaining hot strength is 995.3kPa; Tensile modulus of elasticity 200kPa.
Embodiment 2
(1) a certain amount of glacial acetic acid is taken respectively with electronic balance, be made into the aqueous acetic acid that mass fraction is 1w/v%, taking certain mass CS/SA(10/2) powder joins in aqueous acetic acid, be configured to the mixed solution of 1w/v%, make it fully dissolve by magnetic stirrer, obtain the solution of stable homogeneous.
(2) in above-mentioned mixed solution, add acrylamide monomer successively, mixed solution is at room temperature stirred 2d until solubilize is even; Then progressively add N, N '-methylene bisacrylamide acyl, calcium sulfate as cross-linking agent, Ammonium Persulfate 98.5 and N, N, N ' N '-tetramethylethylenediamine as catalyst, at room temperature continue to stir 1h, the solution for preparing at room temperature left standstill 0.5-2h deaeration; The solution left standstill is poured in glass mold, at room temperature leaves standstill and guarantee its complete reaction a whole night.Wherein: the mass ratio of chitosan and sodium alginate mixed-powder and acrylamide monomer is 1:7, N, the mass ratio of N '-methylene bisacrylamide acyl cross-linking agent and acrylamide monomer is 0.0010, the mass ratio of calcium sulfate and acrylamide monomer is 0.016, the mass ratio of Ammonium persulfate. and acrylamide monomer is 0.010, N, N, N ', N ' mass ratio of-tetramethylethylenediamine and acrylamide monomer is 0.0030.
(3) hydrogel prepared is fully immersed in the CaCl that concentration is 0.5M
212h in solution, cation diffuses in hydrogel network structure, induction chitosan and sodium alginate cross-linking, produces the composite aquogel adherence preventing material of high-strength and high-ductility.
Carry out extension test to obtained hydrogel, obtaining hot strength is 999.8kPa; Tensile modulus of elasticity 285kPa.
Embodiment 3
(1) a certain amount of glacial acetic acid is taken respectively with electronic balance, be made into the aqueous acetic acid that mass fraction is 0.5w/v%, taking certain mass CS/SA(9/3) powder joins in aqueous acetic acid, be configured to the mixed solution of 1w/v%, make it fully dissolve by magnetic stirrer, obtain the solution of stable homogeneous.
(2) in above-mentioned mixed solution, add acrylamide monomer successively, mixed solution is at room temperature stirred 2d until solubilize is even; Then progressively add N, N '-methylene bisacrylamide acyl, calcium sulfate as cross-linking agent, Ammonium Persulfate 98.5 and N, N, N ' N '-tetramethylethylenediamine as catalyst, at room temperature continue to stir 1.5h, the solution for preparing at room temperature left standstill 0.5-2h deaeration; The solution left standstill is poured in glass mold, at room temperature leaves standstill and guarantee its complete reaction a whole night.The mass ratio of chitosan and sodium alginate mixed-powder and acrylamide monomer is 1:8, N, the mass ratio of N '-methylene bisacrylamide acyl cross-linking agent and acrylamide monomer is 0.0012, the mass ratio of calcium sulfate and acrylamide monomer is 0.016, the mass ratio of Ammonium persulfate. and acrylamide monomer is 0.012, N, N, N ', N ' mass ratio of-tetramethylethylenediamine and acrylamide monomer is 0.0035.
(3) hydrogel prepared is fully immersed in the CaCl that concentration is 1M
212h in solution, cation diffuses in hydrogel network structure, induction chitosan and sodium alginate cross-linking, produces the composite aquogel adherence preventing material of high-strength and high-ductility.
Carry out extension test to obtained hydrogel, obtaining hot strength is 1166.5kPa; Tensile modulus of elasticity 190.5kPa.
Embodiment 4
(1) a certain amount of glacial acetic acid is taken respectively with electronic balance, be made into the aqueous acetic acid that mass fraction is 1.5w/v%, taking certain mass CS/SA(10/2) powder joins in aqueous acetic acid, be configured to the mixed solution of 1.5w/v%, make it fully dissolve by magnetic stirrer, obtain the solution of stable homogeneous.
(2) in above-mentioned mixed solution, add acrylamide monomer successively, mixed solution is at room temperature stirred 2d until solubilize is even; Then progressively add N, N '-methylene bisacrylamide acyl, calcium sulfate as cross-linking agent, Ammonium Persulfate 98.5 and N, N, N ' N '-tetramethylethylenediamine as catalyst, at room temperature continue to stir 1.5h, the solution for preparing at room temperature left standstill 0.5-2h deaeration; The solution left standstill is poured in glass mold, at room temperature leaves standstill and guarantee its complete reaction a whole night.Wherein: the mass ratio of chitosan and sodium alginate mixed-powder and acrylamide monomer is 1:10, N, the mass ratio of N '-methylene bisacrylamide acyl cross-linking agent and acrylamide monomer is 0.0018, the mass ratio of calcium sulfate and acrylamide monomer is 0.016, the mass ratio of Ammonium persulfate. and acrylamide monomer is 0.018, N, N, N ', N ' mass ratio of-tetramethylethylenediamine and acrylamide monomer is 0.0025.
(3) hydrogel prepared is fully immersed in the CaCl that concentration is 1M
212h in solution, cation diffuses in hydrogel network structure, induction chitosan and sodium alginate cross-linking, produces the composite aquogel adherence preventing material of high-strength and high-ductility.
Carry out extension test to obtained hydrogel, obtaining hot strength is 736.5kPa; Tensile modulus of elasticity 68.5kPa.
Embodiment 5
(1) a certain amount of glacial acetic acid is taken respectively with electronic balance, be made into the aqueous acetic acid that mass fraction is 2w/v%, taking certain mass CS/SA(8/3) powder joins in aqueous acetic acid, be configured to the mixed solution of 2w/v%, make it fully dissolve by magnetic stirrer, obtain the solution of stable homogeneous.
(2) in above-mentioned mixed solution, add acrylamide monomer successively, mixed solution is at room temperature stirred 2d until solubilize is even; Then progressively add N, N '-methylene bisacrylamide acyl, calcium sulfate as cross-linking agent, Ammonium Persulfate 98.5 and N, N, N ' N '-tetramethylethylenediamine as catalyst, at room temperature continue to stir 2h, the solution for preparing at room temperature left standstill 0.5-2h deaeration; The solution left standstill is poured in glass mold, at room temperature leaves standstill and guarantee its complete reaction a whole night.Wherein: the mass ratio of chitosan and sodium alginate mixed-powder and acrylamide monomer is 1:10, N, the mass ratio of N '-methylene bisacrylamide acyl cross-linking agent and acrylamide monomer is 0.0025, the mass ratio of calcium sulfate and acrylamide monomer is 0.016, the mass ratio of Ammonium persulfate. and acrylamide monomer is 0.025, N, N, N ', N ' mass ratio of-tetramethylethylenediamine and acrylamide monomer is 0.0055.
(3) hydrogel prepared is fully immersed in the CaCl that concentration is 1M
224h in solution, cation diffuses in hydrogel network structure, induction chitosan and sodium alginate cross-linking, produces the composite aquogel adherence preventing material of high-strength and high-ductility.
Carry out extension test to obtained hydrogel, obtaining hot strength is 683.7kPa; Tensile modulus of elasticity 78.7kPa.
Chitosan (CS) used in above embodiment is off-white powder, deacetylation >70%, and rank is medical grade.Described sodium alginate (SA) is white powder, and rank is medical grade.
Claims (10)
1. a post-operation adhesion preventing hydrogel, it is characterized in that described hydrogel is by sodium alginate powder, Chitosan powder, acrylamide monomer, N, N '-methylene-bisacrylamide, calcium sulfate, Ammonium Persulfate 98.5 and N, N, N ' N '-tetramethylethylenediamine is prepared from, wherein, the mass ratio of Chitosan powder and sodium alginate powder is 8-10:1-3, the mass ratio of chitosan and sodium alginate mixed-powder and acrylamide monomer is 1:3-20, N, the mass ratio of N '-methylene bisacrylamide acyl and acrylamide monomer is 0.0006-0.0025, the mass ratio of calcium sulfate and acrylamide monomer is 0.016, the mass ratio of Ammonium persulfate. and acrylamide monomer is 0.006-0.03, N, N, N ', the mass ratio of N '-tetramethylethylenediamine and acrylamide monomer is 0.0025-0.0055.
2. post-operation adhesion preventing hydrogel according to claim 1, it is characterized in that the mass ratio of described Chitosan powder and sodium alginate powder is 9:1, the mass ratio of chitosan and sodium alginate mixed-powder and acrylamide monomer is 1:5, N, the mass ratio of N '-methylene bisacrylamide acyl cross-linking agent and acrylamide monomer is 0.0006, the mass ratio of calcium sulfate and acrylamide monomer is 0.016, the mass ratio of Ammonium persulfate. and acrylamide monomer is 0.006, N, N, N ', N ' mass ratio of-tetramethylethylenediamine and acrylamide monomer is 0.0025.
3. post-operation adhesion preventing hydrogel according to claim 1, it is characterized in that the mass ratio of described Chitosan powder and sodium alginate powder is 10:2, the mass ratio of chitosan and sodium alginate mixed-powder and acrylamide monomer is 1:7, N, the mass ratio of N '-methylene bisacrylamide acyl cross-linking agent and acrylamide monomer is 0.0010, the mass ratio of calcium sulfate and acrylamide monomer is 0.016, the mass ratio of Ammonium persulfate. and acrylamide monomer is 0.010, N, N, N ', N ' mass ratio of-tetramethylethylenediamine and acrylamide monomer is 0.0030.
4. post-operation adhesion preventing hydrogel according to claim 1, it is characterized in that the mass ratio of described Chitosan powder and sodium alginate powder is 9:3, the mass ratio of chitosan and sodium alginate mixed-powder and acrylamide monomer is 1:8, N, the mass ratio of N '-methylene bisacrylamide acyl cross-linking agent and acrylamide monomer is 0.0012, the mass ratio of calcium sulfate and acrylamide monomer is 0.016, the mass ratio of Ammonium persulfate. and acrylamide monomer is 0.012, N, N, N ', N ' mass ratio of-tetramethylethylenediamine and acrylamide monomer is 0.0035.
5. post-operation adhesion preventing hydrogel according to claim 1, it is characterized in that the mass ratio of described Chitosan powder and sodium alginate powder is 10:2, the mass ratio of chitosan and sodium alginate mixed-powder and acrylamide monomer is 1:10, N, the mass ratio of N '-methylene bisacrylamide acyl cross-linking agent and acrylamide monomer is 0.0018, the mass ratio of calcium sulfate and acrylamide monomer is 0.016, the mass ratio of Ammonium persulfate. and acrylamide monomer is 0.018, N, N, N ', N ' mass ratio of-tetramethylethylenediamine and acrylamide monomer is 0.0025.
6. post-operation adhesion preventing hydrogel according to claim 1, it is characterized in that the mass ratio of described Chitosan powder and sodium alginate powder is 8:3, the mass ratio of chitosan and sodium alginate mixed-powder and acrylamide monomer is 1:10, N, the mass ratio of N '-methylene bisacrylamide acyl cross-linking agent and acrylamide monomer is 0.0025, the mass ratio of calcium sulfate and acrylamide monomer is 0.016, the mass ratio of Ammonium persulfate. and acrylamide monomer is 0.025, N, N, N ', N ' mass ratio of-tetramethylethylenediamine and acrylamide monomer is 0.0055.
7. the post-operation adhesion preventing hydrogel according to claim 1,2,3,4,5 or 6, it is characterized in that described chitosan is off-white powder, deacetylation >70%, rank is medical grade; Sodium alginate is white powder, and rank is medical grade.
8. a preparation method for the post-operation adhesion preventing hydrogel described in the arbitrary claim of claim 1-6, is characterized in that described method step is as follows:
The first step: at ambient temperature chitosan and sodium alginate mixed-powder are dissolved in aqueous acetic acid, make it fully dissolve by magnetic stirrer, obtain the mixed solution of stable homogeneous;
Second step: add acrylamide monomer in the mixed solution obtained to the first step successively, mixed solution is at room temperature stirred 10-48h until solubilize is even; Then progressively add N, N '-methylene-bisacrylamide, calcium sulfate as cross-linking agent, Ammonium Persulfate 98.5 and N, N, N ' N '-tetramethylethylenediamine as catalyst, at room temperature continue to stir 0.5-3h, the solution for preparing at room temperature left standstill 0.5-2h deaeration; The solution left standstill is poured in glass mold, at room temperature leaves standstill 6-10h and guarantee its complete reaction, obtain hydrogel;
3rd step: the hydrogel prepared by second step is fully immersed in the CaCl that concentration is 0.05-1.5M
23-36h in solution, cation diffuses in hydrogel network structure, and induction chitosan and sodium alginate cross-linking, prepare the composite aquogel adherence preventing material of high-strength and high-ductility.
9. the preparation method of post-operation adhesion preventing hydrogel according to claim 8, it is characterized in that the concentration of described first step aqueous acetic acid is 0.5-2w/v%, in mixed solution, the concentration of chitosan and sodium alginate mixed-powder is 0.5-2%(w/w).
10. the preparation method of post-operation adhesion preventing hydrogel according to claim 8, it is characterized in that in the described first step, chitosan is off-white powder, deacetylation >70%, rank is medical grade, sodium alginate is white powder, and rank is medical grade.
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