CN109700988A - Nourishing the stomach volatile oil and nourishing the stomach rice paste, nourishing the stomach micro-capsule and nourishing the stomach patch containing the nourishing the stomach volatile oil - Google Patents
Nourishing the stomach volatile oil and nourishing the stomach rice paste, nourishing the stomach micro-capsule and nourishing the stomach patch containing the nourishing the stomach volatile oil Download PDFInfo
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Abstract
The invention discloses a kind of nourishing the stomach volatile oil and the paste of the nourishing the stomach rice containing the nourishing the stomach volatile oil, nourishing the stomach micro-capsule and nourishing the stomach patch.Nourishing the stomach volatile oil of the invention includes the component of following parts by weight: 5-10 parts of Oleum Citri Reticulatae, 5-10 parts of oil of ginger, 5-10 parts of patchouli oil, 5-10 parts of fennel oil and 5-10 parts of mace oil.The nourishing the stomach volatile oil uses natural traditional Chinese medicine essential oil to be mixed for raw material, is free of additive, safe and non-toxic.The nourishing the stomach rice paste, nourishing the stomach micro-capsule and nourishing the stomach patch all have good appetizing digestion-aid effect, it can reach certain reinforcement gastrointestinal motility effect, mitigate the symptoms such as abdominal distension, it is suitable for daily gastrointestinal tract maintenance, and the nourishing the stomach rice paste, nourishing the stomach micro-capsule and the use easy to carry of nourishing the stomach patch, meet modern Man's Demands.
Description
Technical field
The present invention relates to tcm fields, and in particular to a kind of nourishing the stomach volatile oil, the nourishing the stomach rice containing the nourishing the stomach volatile oil
Paste, nourishing the stomach micro-capsule and nourishing the stomach patch.
Background technique
Since modern society's people's lives rhythm is fast, stress is big, there is various stomach trouble and stomach in more and more people
The symptoms such as swollen, belch, nausea and vomiting, but alleviating the mostly of the symptom on the market is drug, and stomach trouble is a kind of chronic disease, needs to grow
Phase maintenance, drug should not be taken for a long time, cannot function as the good selection for maintaining stomach for a long time.
Therefore, it is badly in need of a kind of suitable gastrointestinal tract daily maintenance product taken for a long time or used on the market.
Summary of the invention
The purpose of the present invention is overcoming above-mentioned technical problem, a kind of suitable nourishing the stomach volatilization taken for a long time or used is provided
Oil, and apply it in rice paste, micro-capsule and patch.
Technical scheme is as follows:
A kind of nourishing the stomach volatile oil, the component including following parts by weight: 5-10 parts of Oleum Citri Reticulatae, 5-10 parts of oil of ginger, the wide leaves of pulse plants
5-10 parts of sesame oil, 5-10 parts of fennel oil and 5-10 parts of mace oil.
Plants essential oil has multiple efficacies, as safely and effectively additive, be widely used in medicine, food,
Among health care product and cosmetics.
Wherein Oleum Citri Reticulatae have regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm effect, cure mainly taste syndrome of qi stagnation, vomiting, hiccup, damp phlegm,
Cold productive cough coughs, thoracic obstruction etc..
Oil of ginger has the effects that inducing sweat and dispelling exogenous evils, warming middle energizer to arrest vomiting, warm lung cough-relieving, Appetizing spleen-tonifying, solving toxin of fish and crab, solution poisoning of drug,
Containing ingredients such as the gingerols for promoting digestive juice secretion.
Patchouli oil, which has, eliminates dampness with aromatics, the preventing or arresting vomiting that whets the appetite, delivers relieving summer-heat and other effects, for turbi damp obstructing in middle-JIAO, the vomiting of gastral cavity ruffian, heat
Wet burnout, not easypro, cold-dampness uncomfortable in chest close heat, abdominal pain is vomited and diarrhoea, nasosinusitis headache.
Fennel oil can stomach invigorating qi-regulating, warming kidney for dispelling cold, promote digest and assimilate, prevent from catching a cold, for abdomen caused by hyperalimentation
Swollen and menalgia also has certain effect.
Mace oil can the puckery intestines of middle benefit gas, promoting the circulation of qi helps digestion, cure mainly void rush down, cold dysentery, abdominal distention, deficiency of food vomiting, place food do not disappear,
Mace oil has wind-dispelling effect to the irritating effect of gastrointestinal tract, and the secretion of gastric juice and stimulating gastrointestinal can be promoted to wriggle on a small quantity.
Preferably, the nourishing the stomach volatile oil includes the raw material of following mass fraction: 5 parts of Oleum Citri Reticulatae, 5 parts of oil of ginger, the wide leaves of pulse plants
5 parts of sesame oil, 5 parts of fennel oil and 5 parts of mace oil.
Preferably, the nourishing the stomach volatile oil includes the raw material of following mass fraction: 10 parts of Oleum Citri Reticulatae, 10 parts of oil of ginger, wide
5 parts of palchouli oil, 5 parts of fennel oil and 5 parts of mace oil.
Preferably, the Oleum Citri Reticulatae is made using steam distillation, is included the following steps: dried orange peel wearing into coarse powder, is added 6
The water of~8 times of amounts impregnates 1~2 hour, redistillation 5~6 hours, obtains Oleum Citri Reticulatae.
Preferably, the oil of ginger uses supercritical CO2Extraction is made, and includes the following steps: after ginger is cleaned through broken
Broken crusher machine is baked to moisture content 6% hereinafter, then in pressure 30MPa, temperature 45 C, CO at 70~75 DEG C2Flow
Extraction time 2~3 hours, obtain oil of ginger under conditions of 380kg/h.
Preferably, the patchouli oil is made using enzymatic hydrolysis assisted extraction method, is included the following steps: in Pogostemon cablin powder
Enzyme is added, enzyme dosage is the 1~1.5% of Pogostemon cablin weight, is digested 1~2 hour under the conditions of pH=4.5,45 DEG C, then carry out
Steam distillation is extracted, and patchouli oil is obtained.
Preferably, the fennel oil is made using soxhlet extraction, includes the following steps: to use ethyl acetate for solvent,
Ethyl acetate dosage is 15~20 times of fennel weight, is continuously extracted at 120 DEG C 0.5~1.5 hour, extracting solution filtering, filter
Liquid vacuum distillation removes solvent, obtains fennel oil.
Preferably, the mace oil is made using ultrasound assisted extraction method, and liquid-to-solid ratio is 9~11mL/g, ultrasonic temperature
It is 55~60 DEG C, ultrasonic time is 0.5~1 hour.
The present invention also provides a kind of nourishing the stomach rice pastes comprising nourishing the stomach volatile oil described above.
Preferably, the nourishing the stomach rice paste further includes beta-cyclodextrin, rice meal, red bean powder and hawthorn powder, wherein described support
Stomach volatile oil, beta-cyclodextrin, rice meal, red bean powder and hawthorn powder mass ratio be 1:8~12:50~100:20~40:5~
10。
Preferably, the preparation method of the nourishing the stomach rice paste includes the following steps:
Appropriate purified water and beta-cyclodextrin are taken, is uniformly mixed；
Nourishing the stomach volatile oil is slowly added dropwise under stiring, is poured into after mixing and carries out extruding inclusion in colloid mill, obtain inclusion compound；
Inclusion compound is 15~20 hours dry at normal pressure, 40 DEG C, it crushes, obtains nourishing the stomach volatile oil-beta-cyclodextrin inclusion compound
Object；
Nourishing the stomach volatile oil-Benexate Hydrochloride is mixed with rice meal, red bean powder and hawthorn powder, obtains nourishing the stomach rice paste.
The present invention also provides a kind of nourishing the stomach micro-capsules comprising nourishing the stomach volatile oil described above.
Preferably, the preparation method of the nourishing the stomach micro-capsule includes the following steps:
It weighs suitable nourishing the stomach volatile oil and gumwater is placed in mortar, rapidly grind 10-20 in the same direction
Minute, obtain emulsion；
Emulsion is transferred to 50 DEG C of constant temperature of progress in container when having emulsion droplet to be formed and being evenly distributed with micro- sem observation
Water-bath is added slowly with stirring gelatin solution；
5% acetum is added dropwise and adjusts pH value to 4 or so；
With micro- sem observation, when having round film layer outside emulsion, addition is preheated to 30 DEG C of distilled water dilution, continues to stir
It mixes, obtains microcapsule suspension；
When microcapsule suspension first being let cool under stiring to 30 DEG C or so, it is transferred to and continues to stir in ice-water bath, it is rapidly cold
But to 10 DEG C or less；
Suitable 37% formalin is added, stirs evenly, then sodium hydroxide solution is added dropwise and adjusts pH value to 8~9；
It stands to micro-capsule sedimentation completely, filters, washs to formaldehydeless smell, obtain wet capsule；
Wet capsule is dry in 50 DEG C or less, obtain dry capsule.
The present invention also provides a kind of nourishing the stomach patches comprising nourishing the stomach volatile oil described above.
Preferably, the preparation method of the nourishing the stomach patch includes the following steps:
Nourishing the stomach volatile oil, dibutyl sebacate, succinic acid are added in solvent, constant temperature oscillation to succinic acid is completely dissolved,
It is 20~22:1~3:10~12 acetone-isopropanol-alcohol mixture that wherein the solvent, which is mass ratio,；
The polyacrylic resin of model Eudragit E100 is added and constant temperature oscillation is to being in flow-like, wherein described support
Stomach volatile oil, dibutyl sebacate, succinic acid, polyacrylic resin, solvent mass ratio be 1~8:60~65:25~30:4
~6:30~40；
It is coated on back sheet using the tape casting, is volatilized naturally；
The finally crosslinking curing in 60 DEG C of baking ovens, obtains nourishing the stomach patch.
Compared to the prior art, nourishing the stomach volatile oil provided by the invention and the nourishing the stomach rice containing the nourishing the stomach volatile oil are pasted, are supported
Stomach micro-capsule and nourishing the stomach patch have the advantages that
One, it uses natural traditional Chinese medicine essential oil to be mixed for raw material, is free of additive, it is safe and non-toxic；
Two, the nourishing the stomach rice paste, nourishing the stomach micro-capsule and nourishing the stomach patch all have good appetizing digestion-aid effect, can reach one
Fixed reinforcement gastrointestinal motility effect, mitigates the symptoms such as abdominal distension, is suitable for daily gastrointestinal tract maintenance；
Three, nourishing the stomach rice paste is easy to use, can be used as that nutrient breakfast is edible, i.e. punching takes, can reach appetizing it is aid digestion,
The effect for maintaining gastrointestinal tract is suitable for daily stomach maintenance；
Four, the nourishing the stomach micro-capsule bioavilability is high, small to gastrointestinal tract mucosa stimulation, and microcapsule formulation can stablize volatilization oiliness
Matter preferably retains effective ingredient, is a kind of good gastrointestinal tract maintenance product；
Five, the nourishing the stomach patch can preferably retain volatile oil component, and easy to use, easy to carry, percutaneous dosing mode
It is safe and non-toxic, it can effectively accelerate gastrointestinal motility；
Six, raw material essential oil is obtained using various novel energy-efficient extracting methods, superior in quality, yield is high；
Seven, the preparation method of the nourishing the stomach volatile oil is simple, can industrial mass production；
Eight, the nourishing the stomach volatile oil can use brown bottle avoid light place, and store method is simple；
Nine, the preparation method of the nourishing the stomach rice paste, nourishing the stomach micro-capsule and nourishing the stomach patch is simple, can industrialized production；
Ten, the nourishing the stomach rice paste, nourishing the stomach micro-capsule and the use easy to carry of nourishing the stomach patch, meet modern Man's Demands.
Specific embodiment
Below with reference to embodiment, the present invention is described in further detail, and embodiments of the present invention are not limited thereto.
Unless stated otherwise, the content is mass percentage；Reagent employed in embodiment, raw material are city
It sells, test method without specific conditions in embodiment, usually according to normal condition or condition recommended by the manufacturer carries out.
The present invention provides a kind of nourishing the stomach volatile oil comprising the component of following parts by weight: 5-10 parts of Oleum Citri Reticulatae, oil of ginger
5-10 parts, 5-10 parts of patchouli oil, 5-10 parts of fennel oil and 5-10 parts of mace oil.
It is opened as long as each component of the nourishing the stomach volatile oil is uniformly mixed can be obtained by by proper proportion with good
Stomach digestion-aid effect and the nourishing the stomach volatile oil for being suitable for daily gastrointestinal tract maintenance.
Table 1 is please referred to, is the nourishing the stomach volatile oil of 1-3 of the embodiment of the present invention and the raw material proportioning table of comparative example 1-2.
The formula of 1 nourishing the stomach volatile oil of table
Wherein the Oleum Citri Reticulatae is made using steam distillation, is included the following steps: dried orange peel wearing into coarse powder, is added 6~8
The water of amount impregnates 1~2 hour again, and redistillation 5~6 hours to get Oleum Citri Reticulatae.It is not used in the process using steam distillation
His organic solvent, ensure that the natural green of essential oil of traditional Chinese medicine is pollution-free.
The oil of ginger uses supercritical CO2Extraction is made, and includes the following steps: broken through crusher after ginger is cleaned
It is broken, moisture content is baked at 70 DEG C 6% hereinafter, 40~60 mesh of degree of grinding of rhizoma zingiberis powder is controlled, then in pressure
30MPa, temperature 45 C, CO2Extraction time 2~3 hours, obtain oil of ginger under conditions of flow 380kg/h.This method recovery rate
Height, in supercritical CO2In the industrial production for extracting oil of ginger, the intrinsic pungent fragrance of ginger is preferably maintained, it more can be big
It is well-established.
The patchouli oil is made using enzymatic hydrolysis assisted extraction method, is included the following steps: in the Pogostemon cablin powder of 40 mesh
Enzyme is added, enzyme dosage is the 1% of Pogostemon cablin weight, is digested 1 hour under the conditions of pH=4.5,45 DEG C, then carry out vapor steaming
Extraction is evaporated, patchouli oil is obtained.This method improves 41.13% than extraction by steam distillation rate.
The fennel oil is made using soxhlet extraction, includes the following steps: to use ethyl acetate for solvent, ethyl acetate
Dosage is 20 times of fennel weight, is continuously extracted at 120 DEG C 50 minutes, and extracting solution filtering, filtrate decompression is distilled off molten
Agent obtains fennel oil.
The mace oil is made using ultrasound assisted extraction method, includes the following steps: the ground nutmeg for weighing 40 mesh
Water, liquid-to-solid ratio 10.2mL/g is added in end, and ultrasonic temperature is 59 DEG C, and ultrasonic time is 39 minutes, obtains mace oil.This method
It is simple and efficient to handle, extraction time is short, recovery rate is high.
The nourishing the stomach volatile oil can be prepared by the following method: according to proportion by Oleum Citri Reticulatae, oil of ginger, patchouli oil, fennel
Sesame oil and mace oil mix, and are uniformly mixed under vacuum conditions with 200r/min revolving speed stirring 10min, finally
Essential oil composition after mixing is fitted into Brown Glass Brown glass bottles and jars only, for using.
Nourishing the stomach rice paste is respectively prepared in nourishing the stomach volatile oil made from above-described embodiment 1-3 and comparative example 1-2, specific proportion is asked
Refering to table 2.
The formula of 2 nourishing the stomach rice of table paste
The preparation method of the nourishing the stomach rice paste: appropriate purified water and beta-cyclodextrin are taken, 10 points are stirred under 1000r/min
Clock makes its mixing；Nourishing the stomach volatile oil is slowly added dropwise under stiring, colloid mill is poured into after mixing, and (power 11kW emulsifies fineness 2~50
μm) in carry out extruding inclusion, obtain inclusion compound；Inclusion compound is 16 hours dry at normal pressure, 40 DEG C, it crushes, obtains nourishing the stomach volatile oil-
Benexate Hydrochloride；Nourishing the stomach volatile oil-Benexate Hydrochloride is mixed with rice meal, red bean powder and hawthorn powder, is obtained feeding
Stomach rice paste.Wherein used rice meal, red bean powder and hawthorn powder are the powder of shortening.
The application method of the nourishing the stomach rice paste are as follows: warm water is taken after mixing it with water, and is rice paste, daily, twice a day.
Nourishing the stomach micro-capsule is respectively prepared in nourishing the stomach volatile oil made from above-described embodiment 1-3 and comparative example 1-2, specific proportion is asked
Refering to table 3.
The formula of 3 nourishing the stomach micro-capsule of table
The preparation method of the nourishing the stomach micro-capsule: weighing suitable nourishing the stomach volatile oil and gumwater is placed in mortar,
It rapidly grinds 10 minutes in the same direction, obtains emulsion；With micro- sem observation, when thering is emulsion droplet to be formed and being evenly distributed, by emulsion
50 DEG C of waters bath with thermostatic control of progress in container are transferred to, gelatin solution is added slowly with stirring；5% acetum is added dropwise and adjusts pH value
To 4 or so；With micro- sem observation, when having round film layer outside emulsion, addition is preheated to 30 DEG C of distilled water dilution, continues to stir
It mixes, obtains microcapsule suspension；When microcapsule suspension first being let cool under stiring to 30 DEG C or so, it is transferred to and continues to stir in ice-water bath
It mixes, rapid cooling is to 10 DEG C or less；Suitable 37% formalin is added, stirs evenly, then sodium hydroxide solution adjusting is added dropwise
PH value is to 8~9；It stands to micro-capsule sedimentation completely, filters, washs to formaldehydeless smell, obtain wet capsule；Wet capsule is dry in 50 DEG C or less
It is dry, obtain dry capsule.
The application method of the nourishing the stomach micro-capsule are as follows: directly swallowed with warm water.
Nourishing the stomach micro-capsule is respectively prepared in nourishing the stomach volatile oil made from above-described embodiment 1-3 and comparative example 1-2, specific proportion is asked
Refering to table 4.
The formula of 4 nourishing the stomach patch of table
The preparation method of the nourishing the stomach patch: dibutyl sebacate, succinic acid are added in solvent, constant temperature oscillation to fourth two
Acid is completely dissolved, wherein the solvent is acetone-isopropanol-alcohol mixture that mass ratio is 21:2.3:11.7；Addition type
Number for Eudragit E100 polyacrylic resin and constant temperature oscillation to being in flow-like, wherein the nourishing the stomach volatile oil, decanedioic acid
Dibutyl ester, succinic acid, polyacrylic resin, solvent mass ratio be 1:62:27.8:5.5:35；Back is coated on using the tape casting
On lining, volatilize naturally；The finally crosslinking curing in 60 DEG C of baking ovens, obtains nourishing the stomach patch.
The application method of the nourishing the stomach patch are as follows: be affixed on ZHONGWAN acupoint, tip of the day.
Compliance test result
One, digestive aid effects are verified
Small white mouse is divided into oral 0.9% sodium chloride solution group (oral contrast group), oral rice by the difference of administration mode
Paste group, oral micro-capsule group, blank cutaneous penetration group (transdermal contrast groups), cutaneous penetration group, every group 20.After 2min is administered, warp
Mouth is put to death small white mouse using cervical dislocation after pouring into methylenum careuleum liquid 0.2mL, 30min, is opened abdominal cavity, is cut off mesenterium, with
Pylorus is that starting point measures methylenum careuleum moving distance and intestinal tube overall length in intestinal tube, and calculates methylenum careuleum mobility, and wherein mouse is given
Pharmaceutical quantities are by weight of adult dosage, and the results are shown in Table 5.
Table 5
From the results shown in Table 5, using the paste of nourishing the stomach rice made of nourishing the stomach volatile oil of the present invention, nourishing the stomach micro-capsule and nourishing the stomach
Patch has certain good facilitation to gastrointestinal motility, can promote to digest and assimilate, and is that good gastrointestinal tract maintenance produces
Product, wherein the nourishing the stomach volatile oil is best using the formulation efficacy of embodiment 2.
Two, nourishing the stomach compliance test result
To show nourishing the stomach effect of the invention, by the nourishing the stomach rice of the embodiment of the present invention 5 paste, embodiment 8 nourishing the stomach micro-capsule and
The nourishing the stomach patch of embodiment 11 is respectively supplied to 300 patients with gastric disease and takes, 100 patients of every kind of product, and to clinical data
Carry out observation statistics.
1, nourishing the stomach rice pastes application method: taking rice paste 100-150g of the present invention, daily early morning is taken after mixing it with water to rice with warm water paste at dusk
Shape is eaten.Continuously taking makees as a treatment course for 2 months, generally takes to the 2-3 course for the treatment of, the gastric disease symptoms of patient can be obtained bright
It is aobvious to alleviate.
Effect counts: the treatment to 100 patients with gastric disease, 3 courses for the treatment of of progress for taking nourishing the stomach rice paste, after a course for the treatment of,
Symptom substantially reduced 63, symptom disappears 13, cure rate 13%；After two courses for the treatment of, symptom substantially reduced 87, symptom
It disappears 35, cure rate 35%；After three courses for the treatment of, symptom disappears 92, remaining 8 the symptoms were significantly improved, and cure rate reaches
92%.
2, nourishing the stomach micro-capsule application method: taking the present invention 1, swallows per daily warm water.2 months are continuously taken as a treatment
Journey is generally taken to the 2-3 course for the treatment of, and the gastric disease symptoms of patient can be relieved.
Effect counts: the treatment to 100 patients with gastric disease, 3 courses for the treatment of of progress for taking the nourishing the stomach micro-capsule, after a course for the treatment of,
Symptom substantially reduced 65, symptom disappears 15, cure rate 15%；After two courses for the treatment of, symptom substantially reduced 80, symptom
It disappears 42, cure rate 42%；After three courses for the treatment of, symptom disappears 94, remaining 6 the symptoms were significantly improved, and cure rate reaches
94%.
3, nourishing the stomach patch application method: a note of the invention is taken, ZHONGWAN acupoint is affixed on daily, sticks 12 hours and tear.Continuously make
Made with 1 month as a treatment course, generally uses the 2-3 course for the treatment of, the gastric disease symptoms of patient can be relieved.
Effect counts: the treatment to 100 patients with gastric disease, 3 courses for the treatment of of progress for using the nourishing the stomach patch, after a course for the treatment of,
Symptom substantially reduced 70, symptom disappeared in 10 cases, cure rate 10%；After two courses for the treatment of, symptom substantially reduced 76, symptom disappears
32 are lost, cure rate 32%；After three courses for the treatment of, symptom disappears 91, remaining 9 the symptoms were significantly improved, and cure rate reaches
91%.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair
Equivalent structure or equivalent flow shift made by bright description is applied directly or indirectly in other relevant technology necks
Domain is included within the scope of the present invention.
Claims (10)
1. a kind of nourishing the stomach volatile oil, which is characterized in that the component including following parts by weight: 5-10 parts of Oleum Citri Reticulatae, oil of ginger 5-
10 parts, 5-10 parts of patchouli oil, 5-10 parts of fennel oil and 5-10 parts of mace oil.
2. nourishing the stomach volatile oil according to claim 1, which is characterized in that the raw material including following mass fraction: Oleum Citri Reticulatae 5
Part, 5 parts of oil of ginger, 5 parts of patchouli oil, 5 parts of fennel oil and 5 parts of mace oil.
3. nourishing the stomach volatile oil according to claim 1, which is characterized in that the raw material including following mass fraction: Oleum Citri Reticulatae
10 parts, 10 parts of oil of ginger, 5 parts of patchouli oil, 5 parts of fennel oil and 5 parts of mace oil.
4. a kind of nourishing the stomach rice paste, which is characterized in that including the described in any item nourishing the stomach volatile oil of claim 1-3.
5. nourishing the stomach rice paste according to claim 4, which is characterized in that the nourishing the stomach rice paste further includes beta-cyclodextrin, rice
Powder, red bean powder and hawthorn powder, wherein the nourishing the stomach volatile oil, beta-cyclodextrin, rice meal, red bean powder and hawthorn powder quality
Than for 1:8~12:50~100:20~40:5~10.
6. nourishing the stomach rice paste according to claim 5, which is characterized in that the preparation method of the nourishing the stomach rice paste includes following step
It is rapid:
Appropriate purified water and beta-cyclodextrin are taken, is uniformly mixed；
Nourishing the stomach volatile oil is slowly added dropwise under stiring, is poured into after mixing and carries out extruding inclusion in colloid mill, obtain inclusion compound；
Inclusion compound is 15~20 hours dry at normal pressure, 40 DEG C, it crushes, obtains nourishing the stomach volatile oil-Benexate Hydrochloride；
Nourishing the stomach volatile oil-Benexate Hydrochloride is mixed with rice meal, red bean powder and hawthorn powder, obtains nourishing the stomach rice paste.
7. a kind of nourishing the stomach micro-capsule, which is characterized in that including the described in any item nourishing the stomach volatile oil of claim 1-3.
8. nourishing the stomach micro-capsule according to claim 7, which is characterized in that the preparation method of the nourishing the stomach micro-capsule includes following step
It is rapid:
It weighs suitable nourishing the stomach volatile oil and gumwater is placed in mortar, rapidly grind 10-20 minutes in the same direction,
Obtain emulsion；
Emulsion is transferred to 50 DEG C of waters bath with thermostatic control of progress in container when having emulsion droplet to be formed and being evenly distributed with micro- sem observation,
It is added slowly with stirring gelatin solution；
5% acetum is added dropwise and adjusts pH value to 4 or so；
With micro- sem observation, when having round film layer outside emulsion, addition is preheated to 30 DEG C of distilled water dilution, continues to stir, obtain
Microcapsule suspension；
When microcapsule suspension first being let cool under stiring to 30 DEG C or so, it is transferred to and continues to stir in ice-water bath, rapid cooling is extremely
10 DEG C or less；
Suitable 37% formalin is added, stirs evenly, then sodium hydroxide solution is added dropwise and adjusts pH value to 8~9；
It stands to micro-capsule sedimentation completely, filters, washs to formaldehydeless smell, obtain wet capsule；
Wet capsule is dry in 50 DEG C or less, obtain dry capsule.
9. a kind of nourishing the stomach patch, which is characterized in that including the described in any item nourishing the stomach volatile oil of claim 1-3.
10. nourishing the stomach patch according to claim 9, which is characterized in that the preparation method of the nourishing the stomach patch includes as follows
Step:
Nourishing the stomach volatile oil, dibutyl sebacate, succinic acid are added in solvent, constant temperature oscillation to succinic acid is completely dissolved, wherein
The solvent is that mass ratio is 20~22:1~3:10~12 acetone-isopropanol-alcohol mixture；
The polyacrylic resin of model Eudragit E100 and constant temperature oscillation is added to being in flow-like, wherein the nourishing the stomach is waved
Hair oil, dibutyl sebacate, succinic acid, polyacrylic resin, solvent mass ratio be 1~8:60~65:25~30:4~6:
30~40；
It is coated on back sheet using the tape casting, is volatilized naturally；
The finally crosslinking curing in 60 DEG C of baking ovens, obtains nourishing the stomach patch.
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| CN110638966A (en) * | 2019-05-09 | 2020-01-03 | 江苏食品药品职业技术学院 | Formula and preparation method of aromatic volatile oil microcapsule and micronized medicinal materials |
| CN115836717A (en) * | 2021-12-31 | 2023-03-24 | 中国热带农业科学院农产品加工研究所 | Galangal stomach-invigorating instant rice paste and preparation method thereof |
| CN116686921A (en) * | 2023-04-28 | 2023-09-05 | 佛山市三水区福临慈美饮料有限公司 | Anise patchouli beverage and preparation method thereof |
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2019
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| CN101700300A (en) * | 2009-11-25 | 2010-05-05 | 南京师范大学 | Traditional Chinese medicine volatile oil composition for treating gastrointestinal dysfunction or irritable bowel syndrome (IBS), and preparation method and applications thereof in preparation of medicaments |
| CN102397524A (en) * | 2011-11-29 | 2012-04-04 | 宝健（中国）日用品有限公司 | Composition for protecting gastric mucosa, nourishing stomach and protecting stomach and preparation method thereof |
| CN105660889A (en) * | 2016-02-18 | 2016-06-15 | 广东雅道生物科技有限公司 | Spiced essential oil and making method thereof |
| CN107456557A (en) * | 2016-06-03 | 2017-12-12 | 陈龙斌 | Aromatotherapy preparation based on essential oil and the device for applying this kind of preparation |
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| 何占坤等: "陈皮、藿香不同提取物对胃肠动力障碍大鼠胃肠平滑肌收缩活动及胃肠激素的影响", 《天津医药》 * |
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| CN110638966A (en) * | 2019-05-09 | 2020-01-03 | 江苏食品药品职业技术学院 | Formula and preparation method of aromatic volatile oil microcapsule and micronized medicinal materials |
| CN115836717A (en) * | 2021-12-31 | 2023-03-24 | 中国热带农业科学院农产品加工研究所 | Galangal stomach-invigorating instant rice paste and preparation method thereof |
| CN116686921A (en) * | 2023-04-28 | 2023-09-05 | 佛山市三水区福临慈美饮料有限公司 | Anise patchouli beverage and preparation method thereof |
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