CN109700882A - A kind of Chinese materia medica preparation and preparation method of hair growth - Google Patents
A kind of Chinese materia medica preparation and preparation method of hair growth Download PDFInfo
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Abstract
The present invention discloses the Chinese materia medica preparation and preparation method of a kind of hair growth, is made by ratio of weight and the number of copies of Radix Codonopsis, Radix Angelicae Sinensis, the tuber of multiflower knotweed, radix rehmanniae preparata, semen ziziphi spinosae, tuber fleeceflower stem, Semen sesami nigrum drug；According to " healthy tendency deposit in, heresy can not be done " and " healthy tendency slightly do not decline person, the then disease of touching " theory of traditional Chinese medical science that resistance will weaken, perverse trend is easy to take advantage of a weak point the present invention at this time, leads to the yin and yang imbalance of body, induces an illness.The mechanism of alopecia is also such.This void includes that the virtual loss of the five internal organs further includes the virtual loss of qi and blood, therefore we use the Chinese medicine of tonifying five zang organs and qi and blood, has the effect of qi-restoratives tranquilizing the mind, selects Chinese herbal granules oral, feature is: convenient, efficient, safety, economy, Small side effects.
Description
Technical field
The present invention discloses a kind of Chinese materia medica preparation of hair growth, invention further provides the preparation method of the drug,
Belong to Chinese medicine pharmaceutical technology field.
Background technique:
Androgenetic alopecia is otherwise known as male pattern alopecia, alopecia generalisata, early bald, alopecia seborrheica, is head volume
The gradual alopecia in temporo area and top is a continuous process.Alopecia areata is commonly called as " alopecia areata ", is a kind of limitation occurred suddenly
The patchy alopecia of property, local skin is normal, no conscious sympton.Androgenetic alopecia is a kind of autosomal dominant polygenes
The hereditary alopecia of Androgen-dependent, most of patient have family history.Prolonged diet is unbalance, psychological pressure is excessive and
Spiritual high-pressure can aggravate or induce the disease.In recent years many studies have shown that the pathogenesis of androgenetic alopecia and male
Hormonal readiness has close relationship.Androgenetic alopecia affected males are more than women according to statistics, and highest disease incidence is 20-
39 years old age brackets, 40-59 years old secondly, 20 years old or less disease incidence is lower.Alopecia areata etiology unknown has lymphocyte leaching in perifollicolar
Profit, and this disease merges other autoimmune diseases (such as leucoderma, atopic dermatitis) sometimes, therefore it is now recognized that the occurrence of this disease
There may be the pathogenesis of autoimmunity, heredodiathesis is also a key factor, may be related to II type of HLA, 25%
Case has family history, furthermore, it is also possible to related with traumatic nerve injury, insanity, infection focus and endocrine disorder.Androgenetic
Although alopecia and alopecia areata will not threat to life, it is a kind of beauty-injurying disease for perplexing the mankind, brings huge essence to patient
Mind and economic pressures.
The drug of western medical treatment androgenetic alopecia at present, is broadly divided into two classes: biologically conditioning agent and swashing
Plain regulator.Biologically conditioning agent includes tretinoin, minoxidil.Hormone regulator includes estrogen-mediated agent, male swashs
Plain blocking agent.Treat the drug of alopecia areata, can be divided into: biologically conditioning agent, immunomodulator, nonspecific stimulation hair are raw
It is long.Biologically conditioning agent is minoxidil solution.Immunomodulator is divided into two classes: one includes ground green onion for local immunity class
Phenol, contact sensitization etc., two be corticosteroid.Modern medicine can also be controlled in addition to curing alopecia with medicine using hair grafting
The disease is treated, some patientss obtain certain effect after receiving this operative treatment.But these drug side-effects are big, and operative treatment
Expense it is high and also unnatural in appearance, so the treatment method of modern medicine has certain limitation.
Summary of the invention
The present invention discloses the Chinese materia medica preparation and preparation method of a kind of hair growth, for treating male sex hormone source property alopecia tool
There is apparent medical effect.
A kind of Chinese materia medica preparation of hair growth of the present invention, it is characterised in that be by following drug by ratio of weight and the number of copies
It is manufactured:
Radix Codonopsis 10~20, Radix Angelicae Sinensis 10~15, the tuber of multiflower knotweed 18~25, radix rehmanniae preparata 10~20, semen ziziphi spinosae 10~15, tuber fleeceflower stem 5~10,
Semen sesami nigrum 10~15.
Optimum ratio of the invention is as follows:
Radix Codonopsis 16g, Radix Angelicae Sinensis 12g, tuber of multiflower knotweed 20g, radix rehmanniae preparata 16g, semen ziziphi spinosae 12g, tuber fleeceflower stem 8g, Semen sesami nigrum 12g.
The preparation method of the Chinese materia medica preparation of a kind of hair growth of the present invention, comprising the following steps: by said medicine
It weighs respectively according to the ratio；
Radix Codonopsis, the fleece-flower root, Semen Ziziphi Spinosae (parched), tuber fleeceflower stem obtain alcohol extract using conventional ethanol extraction process；
Radix Angelicae Sinensis, Rehmannia glutinosa obtain water extract using conventional water extraction process；
Semen sesami nigrum is directly beaten after powder is mixed with above-mentioned alcohol extract, water extract and is made of conventional drug granule preparation process
Preparation.
[usage and dosage]: twice daily, 3~5g/ times, 50-150ml warm boiled water is respectively used after morning and evening dinner.3 months are one
A course for the treatment of.
[indication]: androgenetic alopecia.
Ming Dynasty's " doctor states " says: " personal hair is all micro- and sends out Sheng person only, what? hundred arteries and veins can Yu Baihui, vim and vigour uplink and for it
Hair tonic ".Therefore the state of hair and internal organs qi-blood relationship are close, there are many cause of disease that successive dynasties document illustrates, there is kidney deficiency, lung damage, blood
The stasis of blood, the deficiency of blood, mind dystrophy etc..It is exemplified below:
1. kidney deficiency: traditional Chinese medicine thinks kidney storing essence, main growth, development and reproduction, Hua Fa.Systematic Compilation of Internal Classic is said: " kidney person, stomach
Pass, occupy last of the twelve Earthly Branches, have one's ideas straightened out two yin and take charge of constraint, thus based on sting the dominator of storing essence；The main water of kidney, is hidden by the essence of five ZANG-organs and six FU-organs
It, therefore in place of saying essence.Hair is the sign of blood condition, essence foot then hemapodium and send out Sheng, therefore its Hua Fa "." Plain Questions ancient times innocence opinion " is said:
" seven years old kidney qi of woman is contained, dental transition hair length.Two or seven and menarche, conception vessel are logical, taichong channel is contained, regular menstrual cycle, therefore has son ... five
Eight kidney qis decline, and alopecia tooth is withered.In upper, face is burnt for six or eight yang-energy failure, and hair temples are issued white.Seven or eight irritabilities decline, and muscle is not active.Eight or eight menses
It exhausts, defective ejaculation, kidney declines, body all pole, then tooth hair is gone." medical secrets of official essence exhaustion opinion and square three head " is pointed out: all essence exhaustion persons of ＂ lead to master
The diseases of the vital organs of the human body is waited, body all pole if the vital organs of the human body decline, and visually without bright, the severe dryness of teeth deals with ＂.It can be seen that if deficiency of kidney-essence, no
It is flourish on energy, epilation is easily caused, so focusing on adjusting kidney in hair growth.Sui Dynasty's Chao Yuanfang (550-630 A.D.) is pointed out in " General Treatise on the Cause and Symptoms of Diseases ":
If " vim and vigour are weak, exhaust through feeble pulse, are unable to Rong Run, therefore beard and hair is bald fall ".In ＂ healthy tendency deposits, heresy can not do ＂ and ＂ healthy tendency and slightly not decline person, touching
Then disease ＂ viewpoint, deficiency of vial QI, then resistance will weaken, and perverse trend is easy to take advantage of a weak point at this time, and the yin-yang of body is caused to be lost
Weighing apparatus, viscera function disorder, to generate disease.Alopecia areata is also in this way, so should be with qi-restoratives for first when treating.?
Emphasis is enriched and is extended with one kind that the medicine of tranquilizing the mind is alopecia treatment method when treating androgenetic alopecia and alopecia areata；
2. the deficiency syndrome of the lung: Qing Dynasty Zhang Zhongyan thinks that " lung governing skin and hair, it is first exhausted that lung loses then fur.Known to the whole body hair, all lung master it,
The withered profit of its hair color is examined, the disease of lung can be observed.Lung covering other viscera, the gas of main the whole body, lung qi is prosperous, and a surname of body fluid ying blood can be helped to send out and apply
Cloth, inside then flourish feeding internal organs, outside then moisturizing fur sky key." Lung Qi deficiency then generates corresponding symptom, wherein Mao Bai and dried-up, it is
More typical symptom；
3. blood stasis: " treatise on blood trouble hemostasis " says that " all system's blood circulating out of vessels have been gone against absolutely with the blood of feeding Rong Zhoushen and do not conformed to, hemostasis
It takes off and does not give birth in the part of the body cavity above the diaphragm housing the heart and lungs, or hair ".Errors in Medicine Corrected says that " epilation, each medical book all say blood trouble, do not know the outer blood stasis of flesh side meat, obstruction
Bloody path, new blood are unable to hair care, therefore falling out ".Blood stasis hair key, stagnant through vapour lock, new blood is difficult to be poured into root of hair and lose it and support, from
And there is the alopecia of large area；
4. the deficiency of blood: " General Treatise on the Cause and Symptoms of Diseases " is said: " punching appoint arteries and veins, the sea of blood of meaning, not Shang lip, if blood Sheng Ze Rong Yufa, therefore
Beard and hair beauty ", " people has ailment said due to cold or exposure in head, has at void partially, then sends out bald and fall, and muscle is withered or such as money is big, or such as refers to that hair is not given birth to, also not greatly
Itch, therefore the perverse head of ghost of meaning "；
5, mind dystrophy: " Lei Zheng Zhi Cai is insomnia " carries: " overtaxing one's nerves in terror, has a guilty conscience then uneasy." have a guilty consicence, it is confused and worried
Therefore it is insomnia.It is insomnia related with the heart, spleen, liver, kidney and deficiency of YIN-blood.Mind dystrophy, essence and blood in-fighting, deficiency of YIN-blood injure liver kidney yin
Blood." generation of Plain Questions the five internal organs " carries: " the tissue connected with the kidney being bone, honor hair." deficiency of liver-yin and kidney-yin, then alopecia.
In conclusion hair condition is often as caused by various factors.The present invention is according to successive dynasties works, in conjunction with patient's common disease
Because drawing up Shengfa Granule certainly: the fleece-flower root, radix rehmanniae preparata, Semen sesami nigrum, Radix Angelicae Sinensis, Radix Codonopsis, semen ziziphi spinosae, tuber fleeceflower stem；
In prescription of the invention, the fleece-flower root, radix rehmanniae preparata, Semen sesami nigrum be monarch drug in a prescription, fleece-flower root sweet-puckery flavor tepor, enriching blood and replenishing vital essence,
Compendium of Material Medica is said: " bitter kidney tonifying, temperature compensation liver can restrain vital essence, so energy blood-nourishing benefit liver, controlling nocturnal emission with astringent drugs kidney-nourishing, muscle reinforcing and bone strengthening, black palpus
Hair ".Modern research shows that the Stilbene Glucoside of the fleece-flower root can be by activating Mitogen activated protein kinase
P38MAPK and transcription factor MITF, promotes the expression of tyrosinase cdna, enhances the activity of tyrosinase, so that it is black to raise B16
The generation of melanocyte in plain oncocyte.Modern pharmacological studies have shown that the micronutrient levels of the fleece-flower root is more, such as calcium, iron, zinc, manganese, pincers
Deng wherein the content highest of iron, is adjustable nerve, endocrine and enzyme system and plays the role of kidney tonifying, black beard and hair；Semen sesami nigrum property
Sweet taste returns liver and spleen kidney channel, has the effects that tonify the liver and kidney, blood-nourishing strengthening the essence, relax bowel and defecation, is more beneficial to alopecia.Taste are
Barn organs are source of generating QI and blood." holograph is given in endowment " of Song Chen Zhi is pointed out: " taste person, the ancestor of the five internal organs, four it is dirty it
Gas is all reported in spleen, therefore all with temper for this when four "；Hair is the sign of blood condition, the blood not filled, then hair is difficult to nourish.Institute
With, when any variation occurs for their function, falling off for hair is easily led to, thus focus on maintenance liver, spleen, stomach and be conducive to treat
Alopecia.Clinically Chinese traditional treatment alopecia, alopecia areata have a large amount of prescriptions, and wherein the fleece-flower root and Semen sesami nigrum frequently go out in black hair prescription
It is existing, illustrate that they have the effect of promoting melanogenesis well.The fleece-flower root and Semen sesami nigrum water extract have activation mushroom tyrosine
Enzyme and the effect for promoting melanogenesis, hyperchromic significant effect.The fleece-flower root and Semen sesami nigrum water extract can significantly increase B16 melanoma
Melanin production in cell, cell proliferation, melanogenesis and tyrosinase activity have activation, and can promote melanocyte
The transcription for generating related gene facilitates hair loss patient and grows dark hair, and radix rehmanniae preparata tepor sweet in flavor, return heart liver kidney channel, Gan Zeneng
It mends, tonifying yin blood, kidney-nourishing essence, Compendium of Material Medica meaning: " filling out marrow, long muscle, promoting vital essence and blood genernation, tonifying five zang organs internal injury is insufficient, promoting blood circulation, benefit
Knowledge, black palpus ".Present invention discover that the fleece-flower root, Semen sesami nigrum compatibility radix rehmanniae preparata, kidney tonifying curative effect more preferably, have corresponded to alopecia " kidney deficiency " and have said,
For monarch drug in a prescription of the invention.
Radix Angelicae Sinensis, Radix Codonopsis are ministerial drug, and Radix Angelicae Sinensis pungent-warm sweet in flavor, return heart Liver Channel, replenishing and activating blood, " Essentials of Materia Medica: " Gan Wenhe blood, enters
Conscience spleen is gas medicine in blood, ease constipation stomach, damp skin, nourishing blood and promoting granulation "；" pharmacological property song includes 400 tastes ": " the sweet temperature of Radix Angelicae Sinensis, green blood are mended The heart helps empty benefit damage, removing blood stasis and bringing forth new life "；The lung is concerned with QI of the whole body, lung damage then impairment of qi, thus compatibility Radix Codonopsis invigorating the lung and benefiting vital QI, Radix Codonopsis sweet taste,
Returns spleen lung channel, can strengthening spleen and tonifying lung, nourishes blood and promotes the production of body fluid.Blood can be angry, and qi promoting blood production, Radix Angelicae Sinensis is gas medicine in blood again, and Radix Codonopsis tonifying Qi is promoted the production of body fluid
Without dry, therefore Radix Astragali and Radix Angelicae Sinensis compatibility are not selected, the power of two medicine matching rich in nutrition promoting blood circulation of Radix Angelicae Sinensis Radix Codonopsis is reinforced.The interpretation of the cause, onset and process of an illness is corresponded to " lung damage, the deficiency of blood, blood stasis " say.
Semen ziziphi spinosae, tuber fleeceflower stem are adjutant, and semen ziziphi spinosae sweet acid is flat, return liver and gallbladder the heart channel of Hang-Shaoyin, have blood-nourishing tonifying liver, antitoxic heart-soothing and sedative, life
The effect of saliva；Tuber fleeceflower stem is sweet in flavor, thoughts of returning home warp, can nourishing blood and tranquilization.Sayed in Jing-Yue Complete Works: " naivete and the person of being insomnia, must ying blood not
Foot, seeks main blood, the deficiency of blood is then difficult nourishing heart, has a guilty conscience, and has ants in one's pants." blood-nourishing can calm the nerves, tranquilizing the mind also can blood-nourishing.Two medicine compatibilities can
Blood-nourishing relieving restlessness and calm the nerves.Alopecia also has " deficiency of blood, mind dystrophy " to say, therefore semen ziziphi spinosae, and the compatibility main purpose of tuber fleeceflower stem is to mend
Blood and tranquilizing mind and help generation.
Though seven taste of drug flavour of a drug of the present invention, to crucial kidney deficiency because aggravating drug ratios, the treatment of different pharmaceutical combination
The common disease factor that effect covers alopecia is essence place of the present invention, therefore hair loss patient takes our efficient height.
The curative effect of drug of the present invention proves:
Animal experiment
Test objective: building androgenetic alopecia animal model, by medicine of the present invention (Shengfa Granule) act on modeling at
Function B6CBAF1/J mouse observes the growth conditions of mouse hair removal section hair, discusses medicine (Shengfa Granule) of the present invention to androgenetic
The therapeutic effect of alopecia animal model.
1. experimental animal
The male B6CBAF1/J mouse of about 10 week old totally 56, weight 20g or so.
2. animal is grouped at random
Above-mentioned mouse is grouped at random, it is empty as experiment to select 13 B6CBAF1/J mouse in 56 male mices at random
White control group, remaining 43 B6CBAF1/J mouse is as experiment mice, sub-cage rearing.After waiting 5 weeks, from blank group and experiment
3 execution are respectively randomly choosed in group, whether modeling is successful to prove experiment.Remaining 40 B6CBAF1/J experiment mices are random
It is divided into 5 groups, i.e., medicine (Shengfa Granule) group, model group, physiological saline group, blank control group and spirolactone suspension group of the present invention.
3. model foundation
3.1 modeling method
Blank group gives injecting normal saline, injection site is that back of mice is parallel to spinal area subcutaneous, dosage 5mg/
Kgd, injection time are 5 weeks.Remaining 4 groups are given injection testosterone propionate, and injection site is that back of mice is parallel to spinal area skin
Under, dosage 5mg/kgd, injection time is 5 weeks.
3.1.1. the successful standard B6CBAF1/J mouse androgenetic alopecia animal model modeling of animal model is successfully sentenced
Disconnected standard: 1, back hair flaking, partial fusion is at sheet.2, the visible apparent seborrhea in back.3, histopathology
Performance, terminal hair/fine hair on birds or animals hair ratio become smaller, hair follicle atrophy, degeneration, disappearance.Meet above-mentioned 3 simultaneously.
3.1.2. the dilution of testosterone propionate injection, the specification of testosterone propionate injection are 25mg:1ml, the weight of mouse
For 20g, dosage needed for every experiment mice is about 0.1mg/d, therefore, in order to easy to operate, needs third to purchase before the injection
Sour Testamone is diluted processing.Testosterone propionate injection and edible oil are diluted by 1:4, and being configured to concentration is 5mg/
The testosterone propionate dilution of ml is vibrated 2 minutes with whirlpool mixed instrument after testosterone propionate diluted, is mixed them thoroughly uniformly
It is spare afterwards.
3.2 administration
3.2.1 modeling process in the entire experiment process, in addition to the remaining mouse of blank group is according to the agent of 5mg/kg.d
Amount is administered continuously, for maintaining the excessive androgen of experiment mice horizontal, medication are as follows: injection testosterone propionate dilution, injection
Position is that back of mice is parallel to spinal area subcutaneous, dosage 5mg/kgd, injection time is 5 weeks.Blank group gives injection life
Manage salt water, injection site is that back of mice is parallel to spinal area subcutaneous, dosage 5mg/kgd, injection time is 5 weeks.
3.2.2 therapeutic administratp started at the success of B6CBAF1/J mouse androgenetic alopecia animal model modeling the 5th week
Drug therapy is given, is converted according to people/mouse bulk area, spirolactone suspension group is given 9mgkg/ days, and Shengfa Granule group is given
Give Shengfa Granule aqueous solution 9mgkg/ days, physiological saline group gives physiological saline 9mgkg/ days, and model group and blank group are not
Administration.
4. the preparation of materials and skin histology paraffin section: materials choose experiment B6CBAF1/J back of mice hair removal section, take
Face accumulates about 1 × 1cm2Size, as deep as fascia, taken tissue fixed with 10% formalin solution, row HE after paraffin section
Dyeing.
5. observation index
5.1 animal gross examination of skeletal muscle during the experiment, examine the back depilation situation of experiment mice.It is being treated
When equal intervening measures, the region for the treatment of is observed, if the symptom of contact dermatitis occur, such as red swelling of the skin, erosion, bubble, break
It bursts, whether there is or not because of abnormal conditions such as trichomadesis caused by external stimulus.The variation of B6CBAF1/J mouse hair follicles is real under the microscope
Test the pathological change of mouse.B6CBAF1/J mouse hair growth cycle is similar with the hair follicles cycle of the mankind, B6CBAF1/J
The histo pathological change of mouse terminal hair and fine hair on birds or animals hair is similar with mankind's terminal hair and fine hair on birds or animals hair pathological change.Its judgment criteria are as follows: terminal hair
Hair shaft pigment is more, and hair shaft diameter is greater than the thickness of unilateral inner root sheath, and fine hair on birds or animals mao mao's dry color element is less, and hair shaft diameter is less than single
The thickness of side inner root sheath.It is horizontal that hair follicle cross section is observed in 100 times of visuals field of optical microscopy, counts terminal hair and fine hair on birds or animals approximate number,
Terminal hair fine hair on birds or animals approximate number is judged by 3 veteran pathologists respectively, when selecting sample, averagely selects 3 visuals field, 3 views
It avoids being overlapped as far as possible between open country, in order to avoid having an impact result, statistics calculates terminal hair/fine hair on birds or animals hair ratio, calculates average, finally
It is for statistical analysis.
Compare between terminal hair/fine hair on birds or animals hair ratio between 1 each group of table
Note: ɑ is compared with blank group, P < 0.05；β is compared with model group, P < 0.05；γ compared with physiological saline group, P <
0.05
Conclusion: of the present invention group can not only improve mouse hair and fall off, the hair follicle of also reversible androgenetic alopecia model
The pathological change of tissue promotes terminal hair to be formed, converts fine hair on birds or animals hair to terminal hair, finally improves terminal hair/fine hair on birds or animals gross appreciation；
Clinical efficacy proves:
1000 patients are chosen using this recipe oral medication, some patients take effect two weeks, and most of patients hair amount is obvious
Increase.
The treatment standard of the disease: it cures: 10%, effectively: 30%, effective: 50%, invalid: 10%.
The diagnostic criteria of the disease:
Tcm diagnosis foundation:
1, property alopecia symptom in male sex hormone source is the excessive spilling of patient's scalp fat, is often accompanied by dandruff and increases, and scalp is greasy,
Itch is obvious.The general hair of patient is soft, and some is also with dandruff dermatitis symptom.Start gradually from overhead alopecia,
Sprawling and forehead, then diffuse in the entire crown.Scalp is greasy and azarin, ties yellow oil scab.Alopecia areata is a kind of non-cicatricial
Alopecia often betides the crinite position of body, and local skin is normal, no conscious sympton.
2, male sex hormone alopecia mostly occurs in youth, and especially brain worker is more common, may be with endocrine, spiritual shape
State, environmental pollution and life stress or heredity etc. are related.Alopecia areata can betide any age, but between twenty and fifty common, both sexes
Disease incidence no significant difference.
3, property hair loss patient hair in male's male sex hormone source gradually falls off, and two temples retreat, and anterior hair line increases, crown size
It sends out thin or even bald, is aggravated in progressive.Patients with alopecia areata, skin lesion shows as the round or non-alopecia cicatrisata of oval, in spot
Bald edge Chang Kejian " exclamation mark " sample hair, hair all or almost all fall off, referred to as whole alopecia.All hairs of whole body (packet
Include chaeta) all fall off, it is referred to as general de-, it is also shown row alopecia of crawling, other exceptions are not present in addition to no hair in lesion skin.
4, the property alopecia of male sex hormone source is characterized by forehead and the gradual alopecia of overhead.This disease is often between 20~30 years old
Morbidity.
5, property alopecia in male sex hormone source has the general morbidity of genetic predisposition more early.This alopecia is mostly first from forehead and two sides
Temples portion starts, and preceding hair line is gradually drawn back place, and forehead gets higher, gradually extends up in M shape, is in chronic process.Later with
Age increases, and overhead hair gradually decreases, and falls off eventually to most of.Also have forehead temples and top alopecia and meanwhile morbidity or head
It is started shedding off from napex.Hair is tapered soft, especially newborn part.The hair at volume top and top can take off completely
It falls, skin smooth, hair pore shrinkage or the fine hair for leaving a small amount of sparse jewelry, expensive clothing and other valuables, and occipitalia and two sides temples still retain normal head
Hair.
6, in the scalp of androgenetic alopecia patient, the hormone-content of protona increases.Patients with alopecia areata may occur in which sometimes
First is abnormal, and most commonly first is recessed, and there are also onychorrhexis.
7, early stage androgenetic alopecia is by skin sem observation, and hair thickness is uneven, and the difference of hair shaft diameter is more than 20%,
It has also been found that fine hair on birds or animals hair increases, hair number is reduced in Follicular Unit, or even empty hair follicle.
The positive effect of the present invention is: being supported according to " healthy tendency deposit in, heresy can not be done " and " healthy tendency slightly do not decline person, the then disease of touching "
The theory of traditional Chinese medical science that drag will weaken, perverse trend is easy to take advantage of a weak point at this time, leads to the yin and yang imbalance of body, induces an illness.Alopecia
Mechanism be also such.This void includes that the virtual loss of the five internal organs further includes the virtual loss of qi and blood, therefore we use among tonifying five zang organs and qi and blood
Medicine has the effect of qi-restoratives tranquilizing the mind, selects Chinese herbal granules oral, feature is: convenient, efficient, safety, economy, Small side effects.
Specific embodiment
Following examples set forth a specific embodiment of the invention, it will be appreciated by those of skill in the art that this
It is merely illustrative, protection scope of the present invention is defined by the appended claims, and those skilled in the art is not
Under the premise of the principle and substance of the present invention, many changes and modifications may be made, these changes
Protection scope of the present invention is each fallen with modification.
Embodiment 1: Radix Codonopsis 10~20, Radix Angelicae Sinensis 10~15, the tuber of multiflower knotweed 18~25, radix rehmanniae preparata 10~20, semen ziziphi spinosae 10~15, night hand over
Rattan 5~10, Semen sesami nigrum 10~15.
Weigh Radix Codonopsis 16g, Radix Angelicae Sinensis 12g, tuber of multiflower knotweed 20g, radix rehmanniae preparata 16g, semen ziziphi spinosae 12g, tuber fleeceflower stem 8g, Semen sesami nigrum 12g；Party
Ginseng, the fleece-flower root, Semen Ziziphi Spinosae (parched), tuber fleeceflower stem obtain alcohol extract using conventional ethanol extraction process；Radix Angelicae Sinensis, Rehmannia glutinosa are using routine
Water extraction process obtains water extract；Semen sesami nigrum directly beats after powder is mixed with above-mentioned alcohol extract, water extract using conventional drug granule
Preparation is made in preparation process.
Embodiment 2:
Weigh Radix Codonopsis 10g, Radix Angelicae Sinensis 10g, tuber of multiflower knotweed 18g, radix rehmanniae preparata 10g, semen ziziphi spinosae 10g, tuber fleeceflower stem 6g, Semen sesami nigrum 10g；Party
Ginseng, the fleece-flower root, Semen Ziziphi Spinosae (parched), tuber fleeceflower stem obtain alcohol extract using conventional ethanol extraction process；Radix Angelicae Sinensis, Rehmannia glutinosa are using routine
Water extraction process obtains water extract；Semen sesami nigrum directly beats after powder is mixed with above-mentioned alcohol extract, water extract using conventional drug granule
Preparation is made in preparation process.
Embodiment 3:
Weigh Radix Codonopsis 20g, Radix Angelicae Sinensis 15g, tuber of multiflower knotweed 25g, radix rehmanniae preparata 20g, semen ziziphi spinosae 15g, tuber fleeceflower stem 10g, Semen sesami nigrum 15g；Party
Ginseng, the fleece-flower root, Semen Ziziphi Spinosae (parched), tuber fleeceflower stem obtain alcohol extract using conventional ethanol extraction process；Radix Angelicae Sinensis, Rehmannia glutinosa are using routine
Water extraction process obtains water extract；Semen sesami nigrum directly beats after powder is mixed with above-mentioned alcohol extract, water extract using conventional drug granule
Preparation is made in preparation process.
Curative effect of the invention is further illustrated by following typical case.
Case 1:
Liu, male, 26 years old, is diagnosed as alopecia areata before treatment, be divided into two for Chinese medicinal granule prepared by embodiment 1 is one daily
Part, 150ml warm boiled water is respectively used after morning and evening dinner.It takes effect within 1 month, then takes 1 month hair and increased significantly than before.
Case 2:
Poplar, female, 19 years old, alopecia ten months, hair oil was more, and head is itched, and need to have one's hair wash daily primary, epilation is remaining to send out sparse
It is simple and unadorned, it is diagnosed as androgenetic alopecia before treatment, is divided into two parts daily by Chinese medicinal granule prepared by embodiment 2 is one, early supper
150ml warm boiled water is respectively used afterwards.It takes 10 doses of back to itch mitigation, hair oil is reduced, and patient very likes, and five doses of following the service, scalp pruritus stops.Altogether
More than 40 agent of medication, new hair have been born.
Case 3:
Zhang, male, 28 years old, scalp grease crossed Sheng, and at M type alopecia, androgenetic alopecia is diagnosed as before treatment, daily will be real
Apply example 3 preparation Chinese medicinal granule it is one be divided into two parts, after morning and evening dinner respectively use 150ml warm boiled water.20 doses of medication is shown in that grease subtracts
It is few, 30 doses of following the service, new hair regeneration.
Claims (4)
1. a kind of Chinese materia medica preparation of hair growth, it is characterised in that be following raw material by ratio of weight and the number of copies made of:
Radix Codonopsis 10 ~ 20, Radix Angelicae Sinensis 10 ~ 15, the tuber of multiflower knotweed 18 ~ 25, radix rehmanniae preparata 10 ~ 20, semen ziziphi spinosae 10 ~ 15, tuber fleeceflower stem 5 ~ 10, Semen sesami nigrum 10 ~
15。
2. a kind of Chinese materia medica preparation of hair growth as described in claim 1, optimum ratio are as follows:
Radix Codonopsis 10g, Radix Angelicae Sinensis 10g, tuber of multiflower knotweed 18g, radix rehmanniae preparata 10g, semen ziziphi spinosae 10g, tuber fleeceflower stem 6g, Semen sesami nigrum 10g.
3. a kind of preparation method of the Chinese materia medica preparation of hair growth according to claim 1, comprising the following steps: will be above-mentioned
Drug weighs respectively according to the ratio；Radix Codonopsis, the fleece-flower root, Semen Ziziphi Spinosae (parched), tuber fleeceflower stem obtain alcohol extract using conventional ethanol extraction process；
Radix Angelicae Sinensis, Rehmannia glutinosa obtain water extract using conventional water extraction process；Semen sesami nigrum directly beats powder and mixes with above-mentioned alcohol extract, water extract
Preparation is made using conventional drug granule preparation process afterwards.
4. a kind of Chinese materia medica preparation of hair growth as claimed in claim 1 or 2 is any dosage form pharmaceutically.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1213548A (en) * | 1997-10-08 | 1999-04-14 | 张三申 | Method for prodn. of pills for growing hair |
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2019
- 2019-02-18 CN CN201910123504.5A patent/CN109700882A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1213548A (en) * | 1997-10-08 | 1999-04-14 | 张三申 | Method for prodn. of pills for growing hair |
Non-Patent Citations (1)
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| 黄灵素: "《传世本草方：大病小病一扫光》", 31 March 2015, 北京联合出版公司 * |
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| CN112400797A (en) * | 2020-11-19 | 2021-02-26 | 北京科技大学 | Rapid construction method of androgen alopecia animal model |
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