CN109692009A - Human eye capillary blood oxygen measuring device and method - Google Patents
Human eye capillary blood oxygen measuring device and method Download PDFInfo
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- CN109692009A CN109692009A CN201811641188.2A CN201811641188A CN109692009A CN 109692009 A CN109692009 A CN 109692009A CN 201811641188 A CN201811641188 A CN 201811641188A CN 109692009 A CN109692009 A CN 109692009A
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- light source
- light
- blood oxygen
- mirror
- human eye
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14555—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for the eye fundus
Abstract
The invention discloses a kind of human eye capillary blood oxygen measuring device and measurement method, measuring device of the invention, including light source, adaptive optics scanning system and data processing equipment；Light source includes first light source, second light source and the third light source for emitting near-infrared wavelength light.The present invention can effectively inhibit movement and the interference of other noises by using multi-wave length adaptive optical system, reduce error, so that measurement accuracy and sensitivity greatly improve.
Description
Technical field
The present invention relates to Oximetry technologies, and in particular to a kind of human eye capillary blood oxygen measuring device and method.
Background technique
Blood oxygen parameter is an important physical signs in clinical measurement, it reflects the oxygen delivery capacity of body.Simultaneously
Enough oxygen is dissolved in blood, is the essential condition that human body keeps normal metabolism.Measurement to blood oxygen, is mainly based upon
The original that the absorption coefficient of light of oxygen-containing hemoglobin (HbO2) and deoxyhemoglobin (Hb) changes with optical wavelength change in blood
It manages to realize.Correlative study shows that the lesion of human eye capillary and " headstroke " have certain connection.
Adaptive optical technique is the automatic control system using optical wavefront as object, utilizes the real-time survey to optical wavefront
Amount-control-correction enables optical system to correct the aberration mainly generated at cornea eye.Hence for eye capillary
Imaging can have higher resolution ratio, and the 3-D image of human eye capillary can be obtained.Therefore can be considered using optics at
As technology, handles and simulate by signal acquisition, analysis, establish multi-wave length adaptive optical system measuring human eye capillary blood
The functional parameters such as oxygen.
Patent document 2010106177825 discloses a kind of device and method for measuring eye ground blood oxygen saturation,
It, for platform, selects the light of at least two different wave lengths with the laser cofocus scanning ophthalmoscope (AOSLO) based on adaptive optics
As the light source of AOSLO, eyeground aberration is corrected using adaptive optics, wavefront is formed by distorting lens and Wavefront sensor and is rectified
Retina is successively imaged in positive closed-loop control system.Defocus is generated using distorting lens, realizes longitudinal chromatography of retina, so as to
Retinal vascular layer same position is imaged.The High-resolution Retinal of obtained multiple wavelength is registrated, and edge
Intravascular multiple most dim spots of vessel extraction and from the point in the most tissue of dim spot fixed range；Data are handled, this blood vessel is obtained
Blood oxygen saturation.
Although the device is also with adaptive optics system, it is anti-interference using dual-wavelength measurement system
Ability is weak, and measurement accuracy and sensitivity need to be improved.
Summary of the invention
In order to solve the problems existing in the prior art, the present invention provides a kind of human eye capillary blood oxygen measuring device and measurement
Method.
The solution that the present invention solves its technical problem is a kind of human eye capillary blood oxygen measuring device, including light
Source, adaptive optics scanning system and data processing equipment；The light that the light source issues passes through adaptive optics scanning system quilt
It is directed to sample, acquisition picture signal is scanned to sample, the data processing equipment extracts described image signal and obtains blood
Oxygen value, the light source include first light source, second light source and the third light source for emitting near-infrared wavelength light.
Further, the central wavelength of above-mentioned first light source is 780nm；The central wavelength of second light source is 800nm, third
The central wavelength of light source is 820nm.
Further, above-mentioned adaptive optics scanning system includes: several optics transmission elements, fiber coupler, reference
Arm, sample arm, spectrometer and camera, the reference arm is interior to be equipped with 4F system and stationary mirror, has wave in the sample arm
Front sensor, wave-front corrector and 4F system；
The light for the three beams different wave length that the light source issues transmits after optics transmission element makes the appropriate adjustments, into optical fiber
Coupler is then divided into two parts, and a part, which enters after the reference arm, focuses to the stationary mirror through 4F system, passes through
Fiber coupler is returned to after reflection again, a part gets to wave-front corrector after several 4F systems into the sample arm
On, then after reflecting and getting to a 4F system, focus to detection target, then through backtracking, and to after wave-front corrector through wave
Front sensor calibrates aberration；The light that the light and reference arm that final sample arm is reflected back are reflected back produces in fiber coupler
Raw interference, by spectrometer detection, through camera imaging.
Further, above-mentioned optics transmission element includes reflecting mirror, collimating mirror and dichroic mirror；
The light that the first light source issues reflects after the first collimating mirror through the first reflecting mirror, and the second light source issues
Light after the second collimating mirror, through the first dichroic mirror reflect,
The light that the third light source issues reflects after the second collimating mirror through the second dichroic mirror；
Light after the first light source reflection penetrates the first dichroic mirror and the second dichroic mirror,
Light after the second light source reflection penetrates the second dichroic mirror,
It converges with the light after third light source reflection, is then reflected by the second reflecting mirror, then through the 4th collimating mirror standard
Enter the fiber coupler after straight.
Further, above-mentioned reference arm includes that 4F system has 1；The sample arm includes that 4F system has 4, light
Successively pass through 3 4F systems after into sample arm, reaches wave-front corrector then using 1 4F system and focus to detection mesh
Mark.
Further, the 4F system of the reference arm is made of collimating mirror and lens；The 4F system of the sample arm is by song
Face microscope group at.
Further, above-mentioned wave-front corrector is deformable mirror.
Further, above-mentioned spectrometer includes collimation lens, lens, transmission-type grating.
Further, above-mentioned camera is linear array CMOS camera.
Another aspect of the present invention additionally provides a kind of measurement method of blood oxygen saturation, based on above-mentioned human eye capillary
Blood vessel blood oxygen measuring device, comprising steps of
S1, the first light source, second light source, third light source are respectively obtained not by the adaptive optics scanning system
Same imaging signal；
S2, data processing equipment obtain first group of data respectively with the imaging signal of first light source and third light source, obtain
First blood oxygenation measurement；First group of data is obtained with the imaging signal of second light source and third light source, obtains the second Oximetry
Value；
S3, the data processing equipment take the average value of first blood oxygenation measurement and the second blood oxygenation measurement, output
As blood oxygen levels.
The beneficial effects of the present invention are: the present invention can effectively overcome wave by using multi-wave length adaptive optical system
Preceding error and interference.The system additionally uses three wave length measuring systems simultaneously, compared to traditional dual-wavelength measurement system, this hair
Bright measuring system takes a mean value with the measurement result of two groups of dual wavelength lights, and then finds out human eye capillary blood oxygen saturation
Degree can effectively inhibit movement and the interference of other noises, reduce error, so that measurement accuracy and sensitivity greatly improve.
Detailed description of the invention
To describe the technical solutions in the embodiments of the present invention more clearly, make required in being described below to embodiment
Attached drawing is briefly described.Obviously, described attached drawing is a part of the embodiments of the present invention, rather than is all implemented
Example, those skilled in the art without creative efforts, can also be obtained according to these attached drawings other designs
Scheme and attached drawing.
Fig. 1 is human eye capillary blood oxygen measuring device structural schematic diagram one provided in an embodiment of the present invention；
Fig. 2 is human eye capillary blood oxygen measuring device structural schematic diagram two provided in an embodiment of the present invention.
Specific embodiment
It is carried out below with reference to technical effect of the embodiment and attached drawing to design of the invention, specific structure and generation clear
Chu is fully described by, to be completely understood by the purpose of the present invention, feature and effect.Obviously, described embodiment is this hair
Bright a part of the embodiment, rather than whole embodiments, based on the embodiment of the present invention, those skilled in the art are not being paid
Other embodiments obtained, belong to the scope of protection of the invention under the premise of creative work.It is each in the invention
A technical characteristic, can be with combination of interactions under the premise of not conflicting conflict.
Referring to Fig.1, a kind of human eye capillary blood oxygen measuring device, including light source, adaptive optics scanning system sum number
According to processing unit；The light that light source issues is directed into sample by adaptive optics scanning system, is scanned acquisition to sample
Picture signal, data processing equipment extract picture signal and obtain blood oxygen levels；Light source includes the first light for emitting near-infrared wavelength light
Source, second light source and third light source.
Measurement to blood oxygen is mainly based upon the light of oxygen-containing hemoglobin (HbO2) and deoxyhemoglobin (Hb) in blood
What absorption coefficient was realized with optical wavelength change and the principle of change.
Specifically, ignoring the decaying caused by transmitted light of the factors such as scattering, reflection, according to Lambert-Beer theorem it is found that
It can be indicated through the light intensity of biological tissue are as follows:
Wherein I is projection light intensity, I0For incident intensity, ε0For the absorption coefficient of light of background information, C0For the light of background information
Absorbing material concentration, L are optical path length；
According to Bill's-Lang Bo law, (1) formula can be expressed as (2) formula:
Wherein εHbO2For the absorption coefficient of light of oxyhemoglobin, CHbO2For the concentration of oxyhemoglobin, εHbFor deoxidation
The absorption coefficient of light of hemoglobin, CHbFor the concentration of deoxyhemoglobin；εHbO2And εHbIt is λ in wavelength1And λ2When light absorption
Coefficient is constant；
Formula (2) is calculated, the content C of oxyhemoglobin is obtainedHbO2With the content C of deoxyhemoglobinHb；
Then the blood oxygen saturation SO of eyeground blood flow can be calculated according to formula (4)2。
Therefore, the solution of the present invention uses three wave length measuring systems, primary to survey compared to traditional dual-wavelength measurement system
Amount can obtain two oximetry values, so as to be averaging twice, therefore can effectively inhibit movement and other noises
Interference, reduce error so that measurement accuracy and sensitivity greatly improve.
With reference to Fig. 2, the human eye capillary blood oxygen measuring device of a specific embodiment of the invention, including light source, it is adaptive
Answer optical scanning system and data processing equipment.
Wherein, in light source, the central wavelength of first light source SLD1 is 780nm；The central wavelength of second light source SLD2 is
The central wavelength of 800nm, third light source SLD3 are 820nm.
Adaptive optics scanning system includes: several optics transmission elements, fiber coupler, reference arm, sample arm, spectrum
Instrument and camera, reference arm is interior to be equipped with stationary mirror and 1 4F system, and wherein 4F system is made of collimating mirror and lens, sample
There is Wavefront sensor, wave-front corrector and 4 4F systems, 4F system are made of distorting lens in arm；Wave-front corrector is can
Distorting lens.
It includes reflecting mirror, collimating mirror and dichroic mirror that optics, which transmits element,；Specifically,
The light that first light source SLD1 is issued is after the first collimating mirror C1, through the first reflecting mirror FM1
Reflection, the light that second light source SLD2 is issued is after the second collimating mirror C2, through the one or two color
Mirror AC1 reflection,
The light that third light source SLD3 is issued reflects after the second collimating mirror C2 through the second dichroic mirror AC2；
Light after first light source SLD1 reflection penetrates the first dichroic mirror AC1 and the second dichroic mirror AC2,
Light after second light source SLD2 reflection penetrates the second dichroic mirror AC2,
It converges, is then reflected by the second reflecting mirror FM2, then through the 4th collimating mirror with the light after third light source SLD3 reflection
Enter the fiber coupler after C4 collimation.
Spectrometer includes collimation lens, and lens transmit glittering formula grating.
Camera is CMOS line-scan digital camera.
In use, the light for the 780nm that first light source SLD1 is issued gets to first after the first collimating mirror C1 in light source part
After reflecting mirror FM1, the first dichroscope AC1 is penetrated, with beating after the second collimating mirror C2 for the second light source SLD2 800nm issued
The light for the 820nm that light and third light source SLD3 after to the first dichroscope AC1 reflection issue is got to after third collimating mirror C3
Light after second dichroscope AC2 reflection all focuses through the 4th collimating mirror C4 after the second reflecting mirror FM2 reflection and enters optical fiber
Coupler is then divided into two parts output, and a part enters reference arm, forms via the 5th collimating mirror C5 and the second lens L2
A 4F system focusing get on third reflecting mirror FM3, through third reflecting mirror FM3 reflection after by identical path return get to light
In fine coupler；It is most of after the 7th collimating mirror C7 collimation into the light of sample arm section, it passes through spectroscope BS and enters first
First 4F system of curved mirror SM1 and the second curved mirror SM2 composition, after getting to the second scanning galvanometer S2, reflection is got to by third
2nd 4F system of curved mirror SM3 and the 4th curved mirror SM4 composition, then gets on the first scanning galvanometer S1, after S1 reflects
It into after the 3rd 4F system being made of the 5th curved mirror SM5 and the 6th curved mirror SM6, gets on distorting lens DM, then reflects and beat
After the 4th 4F system formed to the 8th curved mirror SM8 by the 7th curved mirror SM7, reflected through the 4th reflecting mirror FM4 and the 4th
Human eye is reached after mirror FM5 reflection, is then focused on eye ground blood vessel through human lens, then light is through backtracking,
The wave front aberration measured after to deformable mirror DM through wavefront sensing WFS calibrates aberration, arrives spectroscope BS rear portion light
Return to fiber coupler after spectroscope BS, a part of light squeezes into Wavefront sensor WFS after being reflected by spectroscope BS, allows wavefront
Sensor WFS carries out wave-front optical aberration measurement, and the aberration after measuring is fed back to deformable mirror DM, carries out deformable mirror DM to it
Correction.The light and the reflected light of reference arm finally returned by sample arm reflection generates interference in fiber coupler, rear to interfere
The spectrometer that signal is formed via the 6th collimating mirror C6, transmission-type grating DG and the first lens L1, carried out on CMOS camera at
Picture.
Another aspect of the present invention additionally provides a kind of measurement method of blood oxygen saturation, based on above-mentioned human eye capillary
Blood vessel blood oxygen measuring device, comprising steps of
S1, first light source, second light source, third light source are respectively obtained different by the adaptive optics scanning system
Imaging signal；
S2, data processing equipment obtain first group of data respectively with the imaging signal of first light source and third light source, obtain
First blood oxygenation measurement；First group of data is obtained with the imaging signal of second light source and third light source, obtains the second Oximetry
Value；
S3, the data processing equipment take the average value of first blood oxygenation measurement and the second blood oxygenation measurement, output
As blood oxygen levels.
Specifically, in first light source SLD1, second light source SLD2, third light source SLD3, the wavelength of sending is respectively λ1、λ2
And λ3Light, point image is formed on CMOS camera after adaptive optics scanning system, then data processing equipment according to
Corresponding wavelength is λ by pixel distribution1、λ2And λ3The image that light is formed is separated, then in the image separated
Each pixel carry out Fast Fourier Transform (FFT), time-domain signal is changed into frequency-region signal, then frequency-region signal is filtered
The low frequency signal of reflection background information, and the high-frequency signal of reflection blood flow information are isolated in wave processing, and wherein low frequency signal is quiet
State signal, high-frequency signal are Dynamic Signal, then pass through the available stationary singnal intensity of Fourier transformationAnd dynamic signal strengthThen respectively with λ1And λ3, λ2And λ3It is one group, according to
Above-mentioned formula (2) (3) (4) calculates two blood oxygen saturation SO2, two values are averaging, just obtain blood oxygen concentration to be measured.
To sum up, the present invention can effectively overcome wavefront error and interference by using multi-wave length adaptive optical system.Together
When the system additionally use three wave length measuring systems, compared to traditional dual-wavelength measurement system, measuring system of the invention is used
The measurement result of two groups of dual wavelength lights takes a mean value, and then finds out human eye o2 saturation of capillary blood, can effectively inhibit
The interference of movement and other noises reduces error, so that measurement accuracy and sensitivity greatly improve.
Better embodiment of the invention is illustrated above, but the invention is not limited to the implementation
Example, those skilled in the art can also make various equivalent modifications on the premise of without prejudice to spirit of the invention or replace
It changes, these equivalent variation or replacement are all included in the scope defined by the claims of the present application.
Claims (10)
1. a kind of human eye capillary blood oxygen measuring device, including light source, adaptive optics scanning system and data processing dress
It sets；The light that the light source issues is directed into sample by adaptive optics scanning system, is scanned acquisition image to sample
Signal, the data processing equipment extract described image signal and obtain blood oxygen levels；It is characterized in that, the light source includes that transmitting is close
First light source, second light source and the third light source of infrared wavelength light.
2. human eye capillary blood oxygen measuring device according to claim 1, which is characterized in that in the first light source
The a length of 780nm of cardiac wave；The central wavelength of the second light source is 800nm, and the central wavelength of the third light source is 820nm.
3. human eye capillary blood oxygen measuring device according to claim 1 or 2, which is characterized in that the adaptive optical
Learning scanning system includes: several optics transmission elements, fiber coupler, reference arm, sample arm, spectrometer, camera, the reference
It is equipped with 4F system, stationary mirror in arm, there is Wavefront sensor, wave-front corrector and 4F system in the sample arm；
The light for the three beams different wave length that the light source issues transmits after optics transmission element makes the appropriate adjustments, into fiber coupling
Device is then divided into two parts, and a part, which enters after the reference arm, focuses to the stationary mirror through 4F system, through reflecting
Returning to fiber coupler again afterwards, a part is got on wave-front corrector after several 4F systems into the sample arm, then
After a 4F system is got in reflection, line focus is to target is detected, then through backtracking, and to being passed after wave-front corrector through wavefront
Sensor calibrates aberration；The light that the light and reference arm that final sample arm is reflected back are reflected back generates dry in fiber coupler
It relates to, by spectrometer detection, through camera imaging.
4. human eye capillary blood oxygen measuring device according to claim 3, it is characterised in that: the optics transmits element
Including reflecting mirror, collimating mirror and dichroic mirror；
The light that the first light source issues reflects after the first collimating mirror C1 through the first reflecting mirror FM1, and the second light source issues
Light after the second collimating mirror C2, reflected through the first dichroic mirror AC1, the light that the third light source issues is through the second collimating mirror C2
Afterwards, it is reflected through the second dichroic mirror AC2；Light after the first light source reflection penetrates the first dichroic mirror AC1 and the second dichroic mirror
AC2, the light after the second light source reflection penetrate the second dichroic mirror AC2,
It converges with the light after third light source reflection, is then reflected by the second reflecting mirror FM2, then is quasi- through the 4th collimating mirror C4
Enter the fiber coupler after straight.
5. human eye capillary blood oxygen measuring device according to claim 3, which is characterized in that the reference arm includes
4F system has 1；The sample arm includes that 4F system has 4, and light enters after sample arm successively by 3 4F systems, arrives
Up to wave-front corrector, then using 1 4F system, detection target is focused to.
6. human eye capillary blood oxygen measuring device according to claim 5, which is characterized in that the 4F system of the reference arm
System is made of collimating mirror and lens；The 4F system of the sample arm is made of curved mirror.
7. human eye capillary blood oxygen measuring device according to claim 3, which is characterized in that the wave-front corrector is
Deformable mirror.
8. human eye capillary blood oxygen measuring device according to claim 3, which is characterized in that the spectrometer includes standard
Straight lens, lens, transmission-type grating.
9. human eye capillary blood oxygen measuring device according to claim 3, which is characterized in that the camera is linear array
CMOS camera.
10. a kind of human eye capillary blood oxygen measuring method, based on such as the described in any item human eye capillaries of claim 1-9
Blood oxygen measuring device, which is characterized in that comprising steps of
S1, the first light source, second light source, third light source are respectively obtained different by the adaptive optics scanning system
Imaging signal；
S2, data processing equipment obtain first group of data respectively with the imaging signal of first light source and third light source, obtain first
Blood oxygenation measurement；First group of data is obtained with the imaging signal of second light source and third light source, obtains the second blood oxygenation measurement；
S3, the data processing equipment take the average value of first blood oxygenation measurement and the second blood oxygenation measurement, export conduct
Blood oxygen levels.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111387992A (en) * | 2020-02-14 | 2020-07-10 | 河南大学 | Thin-layer tissue blood oxygen imaging method and device based on Lambert beer law |
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