CN210249850U - Blood oxygen measuring device for human eye capillary - Google Patents
Blood oxygen measuring device for human eye capillary Download PDFInfo
- Publication number
- CN210249850U CN210249850U CN201822273736.2U CN201822273736U CN210249850U CN 210249850 U CN210249850 U CN 210249850U CN 201822273736 U CN201822273736 U CN 201822273736U CN 210249850 U CN210249850 U CN 210249850U
- Authority
- CN
- China
- Prior art keywords
- light source
- light
- reflected
- mirror
- arm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Eye Examination Apparatus (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The utility model discloses a human eye capillary blood oxygen measuring device, which comprises a light source and an adaptive optical scanning system; the light source comprises a first light source, a second light source and a third light source which emit near-infrared wavelength light. The adaptive optics scanning system includes: the device comprises a plurality of optical transmission elements, an optical fiber coupler, a reference arm, a sample arm, a spectrometer and a camera, wherein a 4F system and a fixed reflector are arranged in the reference arm, and a wavefront sensor, a wavefront corrector and a 4F system are arranged in the sample arm. The utility model discloses an adopt multi-wavelength self-adaptation optical system, can effectively restrain the interference of motion and other noises, reduce the error for measurement accuracy and sensitivity improve greatly.
Description
Technical Field
The utility model relates to a blood oxygen measurement technique, concretely relates to human eye capillary blood oxygen measuring device.
Background
Blood oxygen parameters are an important physiological indicator in clinical measurements, which reflects the oxygen supply capacity of the body. Meanwhile, enough oxygen is dissolved in blood, which is an important condition for human body to maintain normal metabolism. The measurement of blood oxygen is mainly realized based on the principle that the light absorption coefficients of oxygenated hemoglobin (HbO2) and deoxygenated hemoglobin (Hb) in blood change along with the change of light wavelength. Related research shows that the pathological changes of human eye capillary vessels are connected with cerebral apoplexy.
The adaptive optics technology is an automatic control system with an optical wavefront as an object, and makes use of real-time measurement-control-correction of the optical wavefront, so that the optical system can correct the aberration mainly generated at the cornea of the eye. Therefore, the imaging of the eye capillary can be performed with higher resolution, and a three-dimensional image of the eye capillary can be obtained. Therefore, the optical imaging technology can be considered, and the multi-wavelength self-adaptive optical system can be established to measure functional parameters such as capillary blood oxygen and the like of the human eyes through signal acquisition, analysis processing and simulation.
Patent document 2010106177825 discloses an apparatus and method for measuring the blood oxygen saturation level of retina of eye fundus, which uses a laser confocal scanning ophthalmoscope (AOSLO) based on adaptive optics as a platform, selects at least two lights with different wavelengths as the light source of the AOSLO, corrects the fundus aberration by using adaptive optics, forms a wavefront correction closed-loop control system through a deformable mirror and a wavefront sensor, and sequentially images the retina. The deformable mirror is used for generating defocusing, so that the longitudinal chromatography of the retina is realized, and the same position of a retinal vascular layer is conveniently imaged. Registering the obtained high-resolution retinal images with multiple wavelengths, and extracting multiple darkest points in the blood vessel and points in the tissue at a fixed distance from the darkest points along the blood vessel; and processing the data to obtain the blood oxygen saturation of the blood vessel.
Although the device also utilizes an adaptive optical system, the device adopts a dual-wavelength measuring system, the anti-interference capability is weak, and the measuring precision and the sensitivity are still to be improved.
Disclosure of Invention
In order to solve the problems existing in the prior art, the utility model provides a human eye capillary blood oxygen measuring device.
The utility model solves the technical problem that the utility model provides a human eye capillary blood oxygen measuring device, which comprises a light source, an adaptive optical scanning system and a data processing device; the light emitted by the light source is guided to a sample through the adaptive optics scanning system, the sample is scanned to obtain an image signal, and the data processing device extracts the image signal to obtain a blood oxygen value; the light source comprises a first light source, a second light source and a third light source which emit near-infrared wavelength light.
Further, the first light source has a center wavelength of 780 nm; the central wavelength of the second light source is 800nm, and the central wavelength of the third light source is 820 nm.
Further, the above adaptive optics scanning system comprises: the device comprises a plurality of optical transmission elements, an optical fiber coupler, a reference arm, a sample arm, a spectrometer and a camera, wherein a 4F system and a fixed reflector are arranged in the reference arm, and a wavefront sensor, a wavefront corrector and a 4F system are arranged in the sample arm;
three beams of light with different wavelengths emitted by the light source are transmitted after being properly adjusted by an optical transmission element, enter the optical fiber coupler and then are divided into two parts, one part enters the reference arm and then is focused to the fixed reflector through the 4F system, returns to the optical fiber coupler after being reflected, and the other part enters the sample arm, passes through a plurality of 4F systems, is shot on the wavefront corrector, is shot on one 4F system after being reflected, is focused to a detection target, then returns through an original path, and is subjected to aberration calibration through the wavefront sensor after reaching the wavefront corrector; and finally, the light reflected by the sample arm and the light reflected by the reference arm generate interference in the optical fiber coupler, are detected by the spectrometer and are imaged by the camera.
Further, the optical transmission element comprises a reflecting mirror, a collimating mirror and a dichroic mirror;
the light emitted by the first light source is reflected by the first reflector after passing through the first collimating mirror, the light emitted by the second light source is reflected by the first dichroic mirror after passing through the second collimating mirror,
the light emitted by the third light source is reflected by the second dichroic mirror after passing through the second collimating mirror;
the light reflected by the first light source penetrates through the first dichroic mirror and the second dichroic mirror,
the light reflected by the second light source is transmitted through the second dichroic mirror,
and the light reflected by the third light source is converged, then is reflected by the second reflecting mirror, and enters the optical fiber coupler after being collimated by the fourth collimating mirror.
Further, the reference arm comprises 1 4F system; the number of the sample arms is 4 including 4F systems, and light rays sequentially pass through the 3 4F systems after entering the sample arms, reach the wavefront corrector, then pass through the 1 4F system, and are focused to a detection target.
Further, the 4F system of the reference arm consists of a collimating mirror and a lens; the 4F system of the sample arm consists of a curved mirror.
Further, the wavefront corrector is a deformable mirror.
Further, the spectrometer comprises a collimating lens, a lens and a transmission type grating.
Further, the camera is a linear array CMOS camera.
The utility model has the advantages that: the utility model discloses an adopt multi-wavelength self-adaptation optical system, can effectual wavefront error of overcoming and disturb. This system has still adopted three wavelength measurement system simultaneously, compares in traditional dual wavelength measurement system, the utility model discloses a measurement system gets once the average value with the measuring result of two sets of dual wavelength light, and then solves human eye capillary blood oxygen saturation, can effectively restrain the interference of motion and other noises, reduces the error for measurement accuracy and sensitivity improve greatly.
Drawings
In order to more clearly illustrate the technical solution in the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly described below. It is clear that the described figures represent only some embodiments of the invention, not all embodiments, and that a person skilled in the art can also derive other designs and figures from these figures without inventive effort.
FIG. 1 is a schematic view of a first embodiment of a device for measuring blood oxygen in capillary vessels of human eyes;
fig. 2 is a schematic structural diagram of a human eye capillary blood oxygen measuring device according to an embodiment of the present invention.
Detailed Description
The conception, the specific structure, and the technical effects produced by the present invention will be clearly and completely described below in conjunction with the embodiments and the accompanying drawings to fully understand the objects, the features, and the effects of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and other embodiments obtained by those skilled in the art without inventive labor based on the embodiments of the present invention all belong to the protection scope of the present invention. All technical characteristics in the invention can be interactively combined on the premise of not conflicting with each other.
Referring to fig. 1, a blood oxygen measuring device for capillary vessels of human eyes comprises a light source, an adaptive optics scanning system and a data processing device; the light emitted by the light source is guided to the sample through the adaptive optics scanning system, the sample is scanned to obtain an image signal, and the data processing device extracts the image signal to obtain a blood oxygen value; the light source comprises a first light source, a second light source and a third light source which emit near-infrared wavelength light.
The measurement of blood oxygen is mainly realized based on the principle that the light absorption coefficients of oxygenated hemoglobin (HbO2) and deoxygenated hemoglobin (Hb) in blood change along with the change of light wavelength.
Specifically, when the attenuation of the transmitted light caused by scattering, reflection, etc. is neglected, the light intensity transmitted through the biological tissue can be expressed as follows from the lambert-beer theorem:
wherein I is the projected light intensity, I0Is the intensity of incident light,. epsilon0Light absorption coefficient as background information, C0The light absorbing substance concentration as background information, L is the light path length;
according to beer-lambert law, formula (1) can be expressed as formula (2):
wherein epsilonHbO2Is the light absorption coefficient of oxyhemoglobin, CHbO2For oxygenation of the concentration of hemoglobin,. epsilonHbIs the light absorption coefficient of deoxyhemoglobin, CHbThe concentration of deoxyhemoglobin; epsilonHbO2And epsilonHbAt a wavelength of λ1And λ2The light absorption coefficient is constant;
calculating the formula (2) to obtain the content C of oxygenated hemoglobinHbO2And the content C of deoxyhemoglobinHb；
Then, the blood oxygen saturation SO of the fundus blood flow can be calculated according to the formula (4)2。
Therefore, the utility model discloses a three wavelength measurement system is adopted to the scheme, compares in traditional dual wavelength measurement system, and once measurement can obtain two blood oxygen saturation values to can ask the average twice, consequently can effectively restrain the interference of motion and other noises, reduce the error, make measurement accuracy and sensitivity improve greatly.
Referring to fig. 2, the device for measuring blood oxygen in capillary vessels of human eyes according to an embodiment of the present invention includes a light source, an adaptive optical scanning system and a data processing device.
Wherein, the central wavelength of the first light source SLD1 in the light source is 780 nm; the central wavelength of the second light source SLD2 was 800nm, and the central wavelength of the third light source SLD3 was 820 nm.
An adaptive optics scanning system comprising: the system comprises a plurality of optical transmission elements, an optical fiber coupler, a reference arm, a sample arm, a spectrometer and a camera, wherein a fixed reflector and 1 4F system are arranged in the reference arm, the 4F system consists of a collimating mirror and a lens, a wavefront sensor, a wavefront corrector and 4F systems are arranged in the sample arm, and the 4F systems consist of deformable mirrors; the wavefront corrector is a deformable mirror.
The optical transmission element comprises a reflecting mirror, a collimating mirror and a dichroic mirror; in particular, the amount of the solvent to be used,
the light emitted by the first light source SLD1 passes through the first collimating mirror C1 and then is reflected by the first reflector FM1, the light emitted by the second light source SLD2 passes through the second collimating mirror C2 and then is reflected by the first dichroic mirror AC1,
light emitted by the third light source SLD3 passes through the second collimating mirror C2 and then is reflected by the second dichroic mirror AC 2;
the light reflected by the first light source SLD1 is transmitted through the first dichroic mirror AC1 and the second dichroic mirror AC2,
the light reflected by the second light source SLD2 is transmitted through the second dichroic mirror AC2,
the light reflected by the third light source SLD3 is converged, then reflected by the second reflector FM2, and then collimated by the fourth collimator C4 to enter the fiber coupler.
The spectrometer comprises a collimating lens, a lens and a transmission blazed grating.
The camera is a CMOS linear array camera.
When the light source is used, in the light source part, 780nm light emitted by a first light source SLD1 passes through a first collimating mirror C1 and then strikes a first reflector FM1, penetrates through a first dichroic mirror AC1, 800nm light emitted by a second light source SLD2 passes through a second collimating mirror C2 and then strikes a first dichroic mirror AC1 to reflect light, 820nm light emitted by a third light source SLD3 passes through a third collimating mirror C3 and then strikes a second dichroic mirror AC2 to reflect light, the light is reflected by a second reflector FM2, then is focused by a fourth collimating mirror C4 to enter an optical fiber coupler and then is divided into two parts to be output, one part of the light enters a reference arm, is focused by a 4F system consisting of a fifth collimating mirror C5 and a second lens L2 and strikes a third reflector FM3, and returns to the optical fiber coupler through the same path after being reflected by a third reflector FM 3; the light entering the sample arm part is mostly collimated by a seventh collimating mirror C7, passes through a spectroscope BS, enters a first 4F system consisting of a first curved mirror SM1 and a second curved mirror SM2, is reflected by a second scanning galvanometer S2, is reflected by a second 4F system consisting of a third curved mirror SM3 and a fourth curved mirror SM4, then is incident on a first scanning galvanometer S1, is reflected by S1, enters a third 4F system consisting of a fifth curved mirror SM5 and a sixth curved mirror SM6, is incident on a deformable mirror DM, is reflected by a fourth 4F system consisting of an eighth curved mirror SM8 of the seventh curved mirror SM7, is reflected by a fourth reflecting mirror FM4 and a fourth reflecting mirror FM5, reaches the human eye, is focused by the human eye lens onto the blood vessel of the fundus oculi, then returns to the original path, is measured by the deformable mirror SM7, is subjected to wavefront aberration measurement by a spectroscope WFS, and is coupled with the spectroscope BS for calibrating the wavefront aberration, part of light is reflected by the spectroscope BS and then is sent into the wave front sensor WFS, the wave front sensor WFS is used for wave front aberration measurement, and the measured aberration is fed back to the deformable mirror DM so that the deformable mirror DM can correct the aberration. Finally, the light reflected by the sample arm and the light reflected by the reference arm generate interference in the fiber coupler, and the rear interference signal is imaged on the CMOS camera through a spectrometer consisting of a sixth collimating mirror C6, a transmission grating DG and a first lens L1.
During measurement, the first light source SLD1, the second light source SLD2 and the third light source SLD3 emit light with the wavelength of lambda1、λ2And λ3Through adaptive opticsScanning the system and forming image on CMOS camera, and data processing unit based on the pixel point distribution to obtain corresponding wavelength λ1、λ2And λ3Separating an image formed by light, performing fast Fourier transform on each pixel point in the separated image, converting a time domain signal into a frequency domain signal, filtering the frequency domain signal, separating a low-frequency signal reflecting background information and a high-frequency signal reflecting blood flow information, wherein the low-frequency signal is a static signal, the high-frequency signal is a dynamic signal, and then obtaining static signal intensity I through Fourier transformsλ1，Isλ2，Isλ3And dynamic signal strength Idλ1，Idλ2，Idλ3Then respectively by λ1And λ3，λ2And λ3As a set, two blood oxygen saturation levels SO are calculated according to the above equations (2), (3) and (4)2The two values are averaged to obtain the blood oxygen concentration to be measured.
To sum up, the utility model discloses an adopt multi-wavelength self-adaptation optical system, can effectual wavefront error of overcoming and disturb. This system has still adopted three wavelength measurement system simultaneously, compares in traditional dual wavelength measurement system, the utility model discloses a measurement system can obtain two blood oxygen data in a measurement equivalent to, can take average value back output measurement result like this for measurement accuracy and sensitivity improve greatly.
While the preferred embodiments of the present invention have been described in detail, it will be understood by those skilled in the art that the invention is not limited to the details of the embodiments shown, but is capable of various modifications and changes without departing from the spirit of the invention.
Claims (7)
1. A human eye capillary blood oxygen measuring device comprises a light source and an adaptive optics scanning system, and is characterized in that the light source comprises a first light source, a second light source and a third light source which emit near-infrared wavelength light;
the central wavelength of the first light source is 780 nm; the central wavelength of the second light source is 800nm, and the central wavelength of the third light source is 820 nm;
the adaptive optics scanning system includes: the device comprises a plurality of optical transmission elements, an optical fiber coupler, a reference arm, a sample arm, a spectrometer and a camera, wherein a 4F system and a fixed reflector are arranged in the reference arm, and a wavefront sensor, a wavefront corrector and a 4F system are arranged in the sample arm;
three beams of light with different wavelengths emitted by the light source are transmitted after being properly adjusted by an optical transmission element, enter the optical fiber coupler and then are divided into two parts, one part enters the reference arm and then is focused to the fixed reflector through the 4F system, returns to the optical fiber coupler after being reflected, and the other part enters the sample arm, passes through a plurality of 4F systems, is shot on the wavefront corrector, is shot on one 4F system after being reflected, is focused to a detection target, then returns through an original path, and is subjected to aberration calibration through the wavefront sensor after reaching the wavefront corrector; and finally, the light reflected by the sample arm and the light reflected by the reference arm generate interference in the optical fiber coupler, are detected by the spectrometer and are imaged by the camera.
2. The device of claim 1, wherein:
the optical transmission element comprises a reflecting mirror, a collimating mirror and a dichroic mirror;
the light emitted by the first light source passes through the first collimating mirror and then is reflected by the first reflector,
the light emitted by the second light source is reflected by the first dichroic mirror after passing through the second collimating mirror,
the light emitted by the third light source is reflected by the second dichroic mirror after passing through the second collimating mirror;
the light reflected by the first light source penetrates through the first dichroic mirror and the second dichroic mirror,
the light reflected by the second light source is transmitted through the second dichroic mirror,
and the light reflected by the third light source is converged, then is reflected by the second reflecting mirror, and enters the optical fiber coupler after being collimated by the fourth collimating mirror.
3. The device of claim 1, wherein said reference arm comprises 1 of a 4F system; the number of the sample arms is 4 including 4F systems, and light rays sequentially pass through the 3 4F systems after entering the sample arms, reach the wavefront corrector, then pass through the 1 4F system, and are focused to a detection target.
4. The device of claim 3 wherein said 4F system of said reference arm is comprised of a collimating lens and a lens; the 4F system of the sample arm consists of a curved mirror.
5. The device of claim 1 wherein said wavefront corrector is a deformable mirror.
6. The device of claim 1, wherein said spectrometer comprises a collimating lens, a lens, and a transmissive grating.
7. The device for measuring blood oxygen in capillary vessels of human eye according to claim 1, wherein said camera is a linear array CMOS camera.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822273736.2U CN210249850U (en) | 2018-12-29 | 2018-12-29 | Blood oxygen measuring device for human eye capillary |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822273736.2U CN210249850U (en) | 2018-12-29 | 2018-12-29 | Blood oxygen measuring device for human eye capillary |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210249850U true CN210249850U (en) | 2020-04-07 |
Family
ID=70010999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201822273736.2U Active CN210249850U (en) | 2018-12-29 | 2018-12-29 | Blood oxygen measuring device for human eye capillary |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210249850U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111436907A (en) * | 2020-04-17 | 2020-07-24 | 佛山科学技术学院 | Cerebrovascular imaging device based on sweep frequency adaptive optics OCT |
| CN112155510A (en) * | 2020-09-30 | 2021-01-01 | 广东唯仁医疗科技有限公司 | Portable adaptive optics OCTA imaging system based on middle numerical aperture |
| CN113940631A (en) * | 2021-10-18 | 2022-01-18 | 中国科学院长春光学精密机械与物理研究所 | Optical coherence tomography system |
-
2018
- 2018-12-29 CN CN201822273736.2U patent/CN210249850U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111436907A (en) * | 2020-04-17 | 2020-07-24 | 佛山科学技术学院 | Cerebrovascular imaging device based on sweep frequency adaptive optics OCT |
| CN112155510A (en) * | 2020-09-30 | 2021-01-01 | 广东唯仁医疗科技有限公司 | Portable adaptive optics OCTA imaging system based on middle numerical aperture |
| CN113940631A (en) * | 2021-10-18 | 2022-01-18 | 中国科学院长春光学精密机械与物理研究所 | Optical coherence tomography system |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN210249850U (en) | Blood oxygen measuring device for human eye capillary | |
| CN102264278B (en) | For the device of swept-source optical coherence domain reflectometry measurement | |
| CN108135466B (en) | Coherent gated wavefront-free sensor adaptive optics multiphoton microscopy and related systems and methods | |
| US10045692B2 (en) | Self-referenced optical coherence tomography | |
| JP6767762B2 (en) | Information processing device, control method of information processing device, and execution program of the control method | |
| KR101515034B1 (en) | Optical coherence tomographic imaging apparatus and control apparatus therefor | |
| US11659992B2 (en) | Ophthalmic apparatus | |
| US11672426B2 (en) | Snapshot photoacoustic photography using an ergodic relay | |
| US20140288419A1 (en) | Method and apparatus for quantitative imaging of blood perfusion in living tissue | |
| JP6607346B2 (en) | Anterior segment optical coherence tomography apparatus and anterior segment optical coherence tomography method | |
| US20160106312A1 (en) | Data processing method and oct apparatus | |
| US10561311B2 (en) | Ophthalmic imaging apparatus and ophthalmic information processing apparatus | |
| WO2022057402A1 (en) | High-speed functional fundus three-dimensional detection system based on near-infrared light | |
| CN101933809A (en) | Multiband reflection spectrum noninvasive blood component measuring device and method | |
| JP6491540B2 (en) | Optical coherence tomography and control method thereof | |
| CN106031629A (en) | A myopic eye scanning module used for an optical coherence tomography instrument | |
| CN109700426B (en) | Portable AO-OCT imaging device | |
| CN109692009A (en) | Human eye capillary blood oxygen measuring device and method | |
| CN113040763B (en) | Blood glucose test method and device based on OCTA | |
| CN102389290B (en) | Frequency-domain optical coherence tomography system | |
| JP6793416B2 (en) | Anterior segment optical interference tomography device and anterior segment optical interference tomography method | |
| CN109691973B (en) | Optical coherence tomography system for measuring eyeball pulsation | |
| CN209915944U (en) | Portable AO-OCT imaging device | |
| CN208693252U (en) | A kind of confocal imaging system based on OCT | |
| CN209733949U (en) | optical coherence tomography system for measuring eyeball pulsation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210707 Address after: 528000 one of the fourth floor of Building 1, block 2, No. 117, Zhangcha 1st Road, Chancheng District, Foshan City, Guangdong Province Patentee after: GUANGDONG WEIREN MEDICAL TECHNOLOGY Co.,Ltd. Address before: 528000 Foshan Institute of science and technology, Xianxi reservoir West Road, Shishan town, Nanhai District, Foshan City, Guangdong Province Patentee before: FOSHAN University |