CN109689890A - 用于子宫腺肌症检测的生物标志物组合及其应用 - Google Patents

用于子宫腺肌症检测的生物标志物组合及其应用 Download PDF

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CN109689890A
CN109689890A CN201780047953.5A CN201780047953A CN109689890A CN 109689890 A CN109689890 A CN 109689890A CN 201780047953 A CN201780047953 A CN 201780047953A CN 109689890 A CN109689890 A CN 109689890A
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seq
adenomyosis
sample
nucleic acid
biomarker
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CN109689890B (zh
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贾慧珏
钟焕姿
宋晓蕾
王子榕
陈晨
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BGI Shenzhen Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
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Abstract

提供用于子宫腺肌症检测或患病风险评估的生物标志物组合及应用。包括四十四条核酸中的至少一条，四十四条核酸分别为Seq ID No.1至Seq ID No.44所示序列，或者分别为与Seq ID No.1至Seq ID No.44所示序列具有97％以上相似性的序列。

Description

PCT国内申请，说明书已公开。

Claims (18)

  1. PCT国内申请，权利要求书已公开。
CN201780047953.5A 2016-09-19 2017-08-07 用于子宫腺肌症检测的生物标志物组合及其应用 Active CN109689890B (zh)

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Application Number Priority Date Filing Date Title
CN201610831104.6A CN107858415B (zh) 2016-09-19 2016-09-19 用于子宫腺肌症检测的生物标志物组合及其应用
CN2016108311046 2016-09-19
PCT/CN2017/096248 WO2018049946A1 (zh) 2016-09-19 2017-08-07 用于子宫腺肌症检测的生物标志物组合及其应用

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Cited By (1)

* Cited by examiner, † Cited by third party
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CN116200485A (zh) * 2022-11-01 2023-06-02 广东省生殖科学研究所(广东省生殖医院) 一种甲基化位点在子宫内膜异位症诊断和分型中的应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020366233A1 (en) * 2019-10-16 2022-05-26 Icahn School Of Medicine At Mount Sinai Systems and methods for detecting a disease condition

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CN1823274A (zh) * 2003-07-14 2006-08-23 株式会社白丽高科 子宫内膜异位相关疾病的诊断方法
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CN101210929A (zh) * 2006-12-29 2008-07-02 中国医学科学院北京协和医院 检测子宫内膜异位症血浆标志蛋白质的方法
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EP2764118A1 (en) * 2011-10-05 2014-08-13 University of Bremen Wnt4 and med12 for use in the diagnosis and treatment of tumor diseases
CN105988002B (zh) * 2015-03-03 2021-01-19 江苏太和吉英医药科技有限公司 Mst1和磷酸化mst1作为子宫内膜容受性检测的方法

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US20020173464A1 (en) * 2000-12-01 2002-11-21 King George L. Modulation of pericyte proliferation
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116200485A (zh) * 2022-11-01 2023-06-02 广东省生殖科学研究所(广东省生殖医院) 一种甲基化位点在子宫内膜异位症诊断和分型中的应用
CN116200485B (zh) * 2022-11-01 2023-12-15 广东省生殖科学研究所(广东省生殖医院) 一种甲基化位点在子宫内膜异位症诊断和分型中的应用

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CN109689890B (zh) 2022-03-25
WO2018049946A1 (zh) 2018-03-22
CN107858415A (zh) 2018-03-30
CN107858415B (zh) 2021-05-28

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