CN109689674A - 从生物溶液中的单体蛋白质分离聚集蛋白质的方法 - Google Patents

从生物溶液中的单体蛋白质分离聚集蛋白质的方法 Download PDF

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Publication number
CN109689674A
CN109689674A CN201780054812.6A CN201780054812A CN109689674A CN 109689674 A CN109689674 A CN 109689674A CN 201780054812 A CN201780054812 A CN 201780054812A CN 109689674 A CN109689674 A CN 109689674A
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CN
China
Prior art keywords
group
monomer
solution
salt
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201780054812.6A
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English (en)
Chinese (zh)
Inventor
S·科拉克·雅谭
A·W·瓦伊尔
J·K·拉斯马森
G·W·格里斯格拉贝尔
C·A·博特霍夫
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3M Innovative Properties Co
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3M Innovative Properties Co
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Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of CN109689674A publication Critical patent/CN109689674A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/40—Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters
    • B01D71/401—Polymers based on the polymerisation of acrylic acid, e.g. polyacrylate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
CN201780054812.6A 2016-09-09 2017-08-30 从生物溶液中的单体蛋白质分离聚集蛋白质的方法 Pending CN109689674A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662385385P 2016-09-09 2016-09-09
US62/385,385 2016-09-09
PCT/US2017/049376 WO2018048698A1 (en) 2016-09-09 2017-08-30 Processes for separating aggregated proteins from monomeric proteins in a biological solution

Publications (1)

Publication Number Publication Date
CN109689674A true CN109689674A (zh) 2019-04-26

Family

ID=59982458

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780054812.6A Pending CN109689674A (zh) 2016-09-09 2017-08-30 从生物溶液中的单体蛋白质分离聚集蛋白质的方法

Country Status (5)

Country Link
US (1) US20190194250A1 (https=)
EP (1) EP3510041B1 (https=)
JP (1) JP7138096B2 (https=)
CN (1) CN109689674A (https=)
WO (1) WO2018048698A1 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN115836095A (zh) * 2020-07-16 2023-03-21 3M创新有限公司 用于毒力抑制的含膦酸酯的聚合物

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US11446613B2 (en) 2016-09-09 2022-09-20 3M Innovative Properties Company Functionalized copolymers and use thereof
CN111511817A (zh) 2017-12-20 2020-08-07 3M创新有限公司 具有连接的含硫代羰基硫基的基团的聚合物基底
WO2019123177A1 (en) 2017-12-20 2019-06-27 3M Innovative Properties Company Polymeric substrates with attached polymeric chains
CN113195567B (zh) 2018-12-19 2023-01-03 3M创新有限公司 两性离子共聚物、涂料组合物、制品和涂覆方法
CN114729084B (zh) 2019-11-25 2023-09-15 3M创新有限公司 含生物素的单体及由其形成的制品
US20230227496A1 (en) * 2020-04-13 2023-07-20 3M Innovative Properties Company Flow-through processes and devices for purifying a target molecule
WO2022013642A1 (en) 2020-07-16 2022-01-20 3M Innovative Properties Company Phosphate-containing copolymers for virulence suppression
WO2024038338A1 (en) * 2022-08-15 2024-02-22 Solventum Intellectual Properties Company Functionalized porous substrates and their use for detecting analytes

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WO2010098867A1 (en) * 2009-02-27 2010-09-02 Millipore Corporation Membrane with sulfonic groups for removing protein aggregates
CN103382215A (zh) * 2012-03-12 2013-11-06 默克专利股份有限公司 以流通方式从生物药物制剂中去除蛋白质聚集体
WO2015050767A1 (en) * 2013-10-03 2015-04-09 3M Innovative Properties Company Ligand-functionalized substrates with enhanced binding capacity

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US4707265A (en) 1981-12-18 1987-11-17 Cuno Incorporated Reinforced microporous membrane
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CN113195567B (zh) * 2018-12-19 2023-01-03 3M创新有限公司 两性离子共聚物、涂料组合物、制品和涂覆方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010098867A1 (en) * 2009-02-27 2010-09-02 Millipore Corporation Membrane with sulfonic groups for removing protein aggregates
CN103382215A (zh) * 2012-03-12 2013-11-06 默克专利股份有限公司 以流通方式从生物药物制剂中去除蛋白质聚集体
WO2015050767A1 (en) * 2013-10-03 2015-04-09 3M Innovative Properties Company Ligand-functionalized substrates with enhanced binding capacity
CN105593276A (zh) * 2013-10-03 2016-05-18 3M创新有限公司 具有增强的结合容量的配体官能化基材

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115836095A (zh) * 2020-07-16 2023-03-21 3M创新有限公司 用于毒力抑制的含膦酸酯的聚合物

Also Published As

Publication number Publication date
US20190194250A1 (en) 2019-06-27
JP2019536736A (ja) 2019-12-19
EP3510041A1 (en) 2019-07-17
EP3510041B1 (en) 2023-05-31
WO2018048698A1 (en) 2018-03-15
JP7138096B2 (ja) 2022-09-15

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