CN109679318A - A kind of medical catheter preparation method of high bacteriostasis property - Google Patents
A kind of medical catheter preparation method of high bacteriostasis property Download PDFInfo
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- CN109679318A CN109679318A CN201710967865.9A CN201710967865A CN109679318A CN 109679318 A CN109679318 A CN 109679318A CN 201710967865 A CN201710967865 A CN 201710967865A CN 109679318 A CN109679318 A CN 109679318A
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- medical catheter
- bacteriostasis property
- preparation
- pelletizing
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L27/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers
- C08L27/02—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L27/04—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment containing chlorine atoms
- C08L27/06—Homopolymers or copolymers of vinyl chloride
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
- C08L53/02—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers of vinyl-aromatic monomers and conjugated dienes
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
- C08L75/04—Polyurethanes
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2237—Oxides; Hydroxides of metals of titanium
- C08K2003/2241—Titanium dioxide
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/18—Applications used for pipes
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2207/00—Properties characterising the ingredient of the composition
- C08L2207/04—Thermoplastic elastomer
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
A kind of medical catheter preparation method of high bacteriostasis property, belong to technical field of medical equipment, operating procedure is as follows: (1) thermoplastic elastomer (TPE), acrylic resin, lubricant, antioxidant, titanium dioxide, plasticizer, oleamide and water being placed in agitator and stir at low speed forming mixture；(2) mixture for obtaining step (1) is sent into screw extruder, extrusion molding；(3) pelletizing；The material of step (2) extrusion molding is sent into pelleter pelletizing；(4) cooling；Material after the completion of pelletizing is cooled down；(5) it is dehydrated；Step (4) material after cooling is sent into centrifugal dehydrator dehydration；(6) it air-dries；The dewatered material of step (5) is subjected to Quick-air-drying；(7) it is molded；Particle is carried out after heating thawing in injection model；(8) it is cooled and shaped.Preparation method of the present invention science, preparation principle is clear, compared with traditional medical catheter, the medical catheter that this method processes can provide good bacteriostasis property, the further satisfaction use demand and usage comfort of sufferer.
Description
Technical field
The invention belongs to technical field of medical equipment, are related to a kind of medical guide rail preparation method, more particularly to a kind of high
The medical catheter preparation method of bacteriostasis property.
Background technique
Medical catheter is equipment most commonly seen in medical treatment, and with the development of interventional medicine, people gradually recognize medical
The significant role of conduit can realize many treatment sexual functions such as diagnosis, treatment, blowdown, chemical examination of disease by medical catheter.For
Further mitigation patient pain, reduces wound infection, people constantly improve conduit.
Lubricity is an important indicator of medical catheter material, currently in order to realizing the lubricity of conduit, usually pair
Catheter surface is modified, and is realized using the polymer of high-hydrophilic in catheter surface plated film, poly- for example, by using grafting hair preparation
The dilute pyrrolidones of oxygen second forms lubricant coating；It is for another example that surface lubrication is durable using inter coat is increased.Chinese Patent Application No.
200810136618.5 use the method lubrication conduit surface of grafting, except that catheter surface is pre-processed,
Reduce the introducing of substance.The method of surface coating is although feasible, but can only realize disposably, and can not achieve recyclable
It utilizes, and there is biggish pressure to environment.
Biocidal property is always focus concerned by people as the most important function of interposing catheter material.At present more according to
It is so surface coating, and realizes lubricity plated film similarly, although surface coating can realize biocidal property within a certain period of time,
But its effect can be reduced rapidly with the rupture of skin covering of the surface.
Summary of the invention
The purpose of the present invention is using surface modification or using surface preparation mode for current medical catheter lubrication, change
The deficiencies of method is poor there are bacteriostasis property provides a kind of medical catheter preparation method of high bacteriostasis property, what this method processed
Medical catheter can provide good bacteriostasis property, can further satisfaction sufferer use demand and usage comfort.
The technical scheme is that a kind of medical catheter preparation method of high bacteriostasis property, which is characterized in that operation step
It is rapid as follows:
(1) thermoplastic elastomer (TPE), acrylic resin, lubricant, antioxidant, titanium dioxide, plasticizer, oleamide and water are set
Enter and carries out stirring at low speed to form mixture in agitator.
(2) mixture that step (1) obtains is sequentially sent to double screw extruder and single screw extrusion machine, extrusion molding；
(3) pelletizing；The material of step (2) extrusion molding is sent into pelleter pelletizing；
(4) cooling；Material after the completion of step (3) pelletizing is cooled down；
(5) it is dehydrated；Step (4) material after cooling is sent into centrifugal dehydrator dehydration；
(6) it air-dries；The dewatered material of step (5) is subjected to Quick-air-drying；
(7) it is molded；Particle is carried out after heating thawing in injection model；
(8) it is cooled and shaped.
The thermoplastic elastomer (TPE) is polyolefins thermoplastic elastic, the phenylethylene Plastic resilient for being 1:1:2 by ratio
Body and polyurethane-type thermoplastic elastomer mixing composition.
Poly- third resin is the polyvinyl chloride resin that the degree of polymerization is 500~800.
The revolving speed of the dual-screw-stem machine is 30~50 revs/min, and single screw extrusion machine die head area's temperature is 160~230 DEG C, spiral shell
The temperature in bar area is 160~230 DEG C.
The cooling temperature is no more than 20 DEG C.
The injection temperature is 160 DEG C~170 DEG C, 190 DEG C~200 DEG C of die temperature.
The invention has the benefit that a kind of medical catheter preparation method of high bacteriostasis property provided by the invention, preparation
Methodological science, preparation principle is clear, and compared with traditional medical catheter, the medical catheter that this method processes can provide good
Bacteriostasis property, the further satisfaction use demand and usage comfort of sufferer.
Specific embodiment
Below with reference to embodiment, the invention will be further described:
A kind of medical catheter preparation method of high bacteriostasis property, operating procedure are as follows:
(1) thermoplastic elastomer (TPE), acrylic resin, lubricant, antioxidant, titanium dioxide, plasticizer, oleamide and water are set
Enter and carries out stirring at low speed to form mixture in agitator.
(2) mixture that step (1) obtains is sequentially sent to double screw extruder and single screw extrusion machine, extrusion molding；
(3) pelletizing；The material of step (2) extrusion molding is sent into pelleter pelletizing；
(4) cooling；Material after the completion of step (3) pelletizing is cooled down；
(5) it is dehydrated；Step (4) material after cooling is sent into centrifugal dehydrator dehydration；
(6) it air-dries；The dewatered material of step (5) is subjected to Quick-air-drying；
(7) it is molded；Particle is carried out after heating thawing in injection model；
(8) it is cooled and shaped.
Thermoplastic elastomer (TPE) is the polyolefin for being 1:1:2 by ratio in a kind of medical catheter preparation method of high bacteriostasis property
Quasi-plastic property elastomer, phenylethylene thermoplastic elastic and polyurethane-type thermoplastic elastomer mixing composition；Poly- third resin is polymerization
The polyvinyl chloride resin that degree is 500~800；The revolving speed of dual-screw-stem machine is 30~50 revs/min, and single screw extrusion machine die head area's temperature is 160
~230 DEG C, the temperature in screw rod area is 160~230 DEG C；Cooling temperature is no more than 20 DEG C；Injection temperature is 160 DEG C~170 DEG C, mouth
190 DEG C~200 DEG C of mould temperature.
Preparation method of the present invention science, preparation principle is clear, compared with traditional medical catheter, doctor that this method processes
With conduit it can provide good bacteriostasis property, the further satisfaction use demand and usage comfort of sufferer.
Claims (6)
1. a kind of medical catheter preparation method of high bacteriostasis property, which is characterized in that operating procedure is as follows:
(1) thermoplastic elastomer (TPE), acrylic resin, lubricant, antioxidant, titanium dioxide, plasticizer, oleamide and water are set
Enter and carries out stirring at low speed to form mixture in agitator；
(2) mixture that step (1) obtains is sequentially sent to double screw extruder and single screw extrusion machine, extrusion molding；
(3) pelletizing；The material of step (2) extrusion molding is sent into pelleter pelletizing；
(4) cooling；Material after the completion of step (3) pelletizing is cooled down；
(5) it is dehydrated；Step (4) material after cooling is sent into centrifugal dehydrator dehydration；
(6) it air-dries；The dewatered material of step (5) is subjected to Quick-air-drying；
(7) it is molded；Particle is carried out after heating thawing in injection model；
(8) it is cooled and shaped.
2. a kind of medical catheter preparation method of high bacteriostasis property according to claim 1, it is characterised in that: the thermoplastic
Property elastomer be by ratio be 1:1:2 polyolefins thermoplastic elastic, phenylethylene thermoplastic elastic and polyurethanes thermoplastic
Property elastomer mixing composition.
3. a kind of medical catheter preparation method of high bacteriostasis property according to claim 1, it is characterised in that: described poly- third
Resin is the polyvinyl chloride resin that the degree of polymerization is 500~800.
4. a kind of medical catheter preparation method of high bacteriostasis property according to claim 1, it is characterised in that: double spiral shells
The revolving speed of bar machine is 30~50 revs/min, and single screw extrusion machine die head area's temperature is 160~230 DEG C, and the temperature in screw rod area is 160
~230 DEG C.
5. a kind of medical catheter preparation method of high bacteriostasis property according to claim 1, it is characterised in that: the cooling
Temperature is no more than 20 DEG C.
6. a kind of medical catheter preparation method of high bacteriostasis property according to claim 1, it is characterised in that: the injection molding
Temperature is 160 DEG C~170 DEG C, 190 DEG C~200 DEG C of die temperature.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710967865.9A CN109679318A (en) | 2017-10-18 | 2017-10-18 | A kind of medical catheter preparation method of high bacteriostasis property |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710967865.9A CN109679318A (en) | 2017-10-18 | 2017-10-18 | A kind of medical catheter preparation method of high bacteriostasis property |
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| CN109679318A true CN109679318A (en) | 2019-04-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710967865.9A Pending CN109679318A (en) | 2017-10-18 | 2017-10-18 | A kind of medical catheter preparation method of high bacteriostasis property |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116423791A (en) * | 2023-06-13 | 2023-07-14 | 南昌大学 | Gas-liquid auxiliary forming device and method for hydrophilic antibacterial medical microtubes |
-
2017
- 2017-10-18 CN CN201710967865.9A patent/CN109679318A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116423791A (en) * | 2023-06-13 | 2023-07-14 | 南昌大学 | Gas-liquid auxiliary forming device and method for hydrophilic antibacterial medical microtubes |
| CN116423791B (en) * | 2023-06-13 | 2023-08-29 | 南昌大学 | Gas-liquid auxiliary forming device and method for hydrophilic antibacterial medical microtubes |
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Application publication date: 20190426 |