CN109675202B - Photodynamic and ultrasonic atomization composite treatment device and treatment method - Google Patents
Photodynamic and ultrasonic atomization composite treatment device and treatment method Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
- A61M2205/051—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0642—Irradiating part of the body at a certain distance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0664—Details
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- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The invention provides a photodynamic and ultrasonic atomization composite treatment device and a treatment method, wherein the device comprises the following components: the host computer is used for determining the treatment time and the irradiation distance, outputting corresponding light source control signals according to a preset light sequencing irradiation mode and preparing the atomized water particles containing oxygen; the irradiator is used for receiving the light source control signal, generating irradiation light meeting the light sequencing irradiation mode, and irradiating a treatment area of a person to be treated according to the treatment time under the irradiation distance; an atomizing spray mechanism for receiving and spraying atomized water particles toward a treatment area of a subject. The invention can realize uniform irradiation of the treatment area of the person to be treated, can realize personalized treatment schemes for different persons to be treated and different treatment areas thereof in a targeted manner, and can also spray aerosol water particles to the treatment area of the person to be treated, thereby effectively preventing the enzymatic reaction speed of the precursor of the photosensitizer substance from being reduced and further improving the photodynamic treatment effect.
Description
Technical Field
The invention relates to the field of photodynamic therapy, in particular to a photodynamic and ultrasonic atomization composite therapeutic device and a therapeutic method.
Background
In recent years, photodynamic therapy (PDT) has been widely used for treating dermatological diseases, medical cosmetic indications, and the like. However, the photodynamic therapy device in the prior art has some problems that firstly, the light scattering angles of the LED chips with different wavelengths in the irradiation light source are different, so that the shapes of the illumination power density distribution curved surfaces of the light with different wavelengths in the therapeutic region of the person to be treated are greatly different, the light energy utilization rate is low, and the illumination is uneven, thereby causing poor photodynamic multispectral combined therapy effect by taking a plurality of LEDs with different wavelengths as the light source; secondly, the method is mainly limited in the aspects of related illumination parameters and light irradiation strategies, such as illumination power density, light source wavelength, treatment time and the like, has limited adjusting capability, cannot fully exert the advantages of multispectral photodynamic therapy, and is not suitable for realizing personalized treatment schemes.
In addition, in the photodynamic therapy process, the skin of the treatment area is dehydrated to a certain extent under the action of the photosensitizer or the precursor of the photosensitizer substance and the irradiation of the irradiation light, and meanwhile, the irradiation of the irradiation light causes local temperature rise on the surface of the skin, so that discomfort such as skin dryness, burning and the like is caused. In addition, some of the precursors of photosensitizer substances widely used clinically are not photosensitive, and the precursors are synthesized into human endogenous photosensitizer protoporphyrin PpIX substances through enzymatic reaction to exert the photosensitization effect, and factors such as temperature rise, dehydration and the like can cause the reduction of the enzymatic reaction speed, so that the quantity of synthesized endogenous photosensitizer is reduced, thereby influencing the effect and application of photodynamic therapy.
Disclosure of Invention
The embodiment of the invention provides a photodynamic and ultrasonic atomization composite treatment device and a treatment method, which are used for solving the problems that in the photodynamic treatment device in the prior art, the irradiation effect of an irradiation light source is poor, a personalized treatment scheme is not suitable to be realized, and the local temperature of the skin surface of a treatment area is easily increased and dried and dehydrated in the photodynamic treatment process, so that the treatment effect is poor.
In a first aspect, embodiments of the present invention provide a photodynamic and ultrasound nebulized composite treatment device, the device comprising:
the host computer is used for determining treatment time and irradiation distance according to preset illumination parameters and outputting corresponding light source control signals according to a preset light sequencing irradiation mode; also used for preparing the atomized water particles containing oxygen;
The irradiator is connected with the host computer and is used for receiving the light source control signals, generating parallel collimated irradiation light with uniform light spots and at least one different peak wavelength meeting the light sequencing irradiation mode, and irradiating a treatment area of a person to be treated according to the treatment time under the irradiation distance;
and the atomization spraying mechanism is connected with the host machine and is used for receiving the atomized water particles and spraying the atomized water particles to the treatment area of the person to be treated.
As a preferred mode of the first aspect of the present invention, the irradiator includes an irradiator end cap and an irradiation light source disposed below the irradiator end cap;
The irradiation light source comprises a multispectral irradiation module, a first optical lens array and a second optical lens array which are sequentially arranged in parallel; the multispectral illumination module comprises a circuit board and at least one multispectral solid-state light-emitting device which can generate parallel collimated light beams with different peak wavelengths and has uniform light spots, and each multispectral solid-state light-emitting device is arranged on the circuit board in an orthogonal array; one side of the first optical lens array, which is provided with a plurality of refraction type small lenses arranged in an orthogonal array, faces towards the multispectral illumination module, one side of the second optical lens array, which is provided with a plurality of refraction type small lenses arranged in an orthogonal array, faces away from the multispectral illumination module, and each small lens on the second optical lens array coincides with the center of each small lens on the first optical lens array and each side corresponds to each other one by one; the distance between the multispectral irradiation module and the first optical lens array is 3-5 mm, and the distance between the first optical lens array and the second optical lens array is 0.85-1.15 times of the focal length of the small lens.
As a preferred mode of the first aspect of the present invention, the multispectral solid-state light-emitting device includes a package substrate, a reflective cup is disposed on a bearing surface of the package substrate, and at least two solid-state light-emitting elements with different peak wavelengths are disposed in a receiving space of the reflective cup; at least two pairs of electrodes are arranged on two sides of the packaging substrate, the electrodes are connected with the anode and the cathode of the solid-state light-emitting element, and the electrodes are also connected with the host; the light outlet of the reflecting cup is also provided with a micro-lens array in a closed mode, the micro-lens array is parallel to the packaging substrate, and one side, provided with a plurality of refraction type hemispherical micro-lenses which are arranged in an orthogonal array, of the micro-lens array faces away from the solid-state light-emitting element.
As a preferable mode of the first aspect of the present invention, the radius of the microlens is 0.05 to 0.25mm, the focal length of the microlens is 0.8mm, and the distance between the circular bottom surfaces of the adjacent microlenses is 0mm.
As a preferred mode of the first aspect of the present invention, the host includes a man-machine interaction unit, a decision control unit, a light source driving unit, and an atomization generating unit, where the man-machine interaction unit, the light source driving unit, and the atomization generating unit are respectively connected to the decision control unit, and the decision control unit and the atomization generating unit are also respectively connected to the atomization spraying mechanism.
As a preferred mode of the first aspect of the present invention, the atomization generating unit includes an ultrasonic atomization chamber, a liquid container, an air supply part, a heating part, an oxygen generating part, an electromagnetic valve, an ozone generating part and an output interface, wherein the liquid container and the air supply part are respectively arranged above and below the ultrasonic atomization chamber, the ultrasonic atomization chamber is connected with the heating part through a pipeline, the oxygen generating part is connected with the electromagnetic valve through a pipeline, the heating part and the electromagnetic valve are respectively connected with the output interface through a three-way joint through a pipeline, and the output interface is also connected with the atomization spraying mechanism; the ozone generating part is arranged on a pipeline of the electromagnetic valve connected with the three-way joint.
As a preferred mode of the first aspect of the present invention, the atomization injection mechanism includes a spray pipe, a water collector and a micro water pump, a water inlet connector is arranged on one side of the spray pipe, a water drainage connector is arranged on one side of the water collector, and the micro water pump is connected with the water inlet connector and the water drainage connector through a water drainage pipe respectively; the water collector is sleeved on the lower end part of the spray pipe and comprises a lower end cover and an upper end cover, a horn-shaped boss extending towards the direction of the upper end cover is arranged on the lower end cover, and a plurality of U-shaped grooves are formed in the periphery of the boss, so that condensation water on the inner wall of the spray pipe enters the water collector through the U-shaped grooves.
In a second aspect, embodiments of the present invention provide a photodynamic and ultrasonic nebulization combined treatment method, the method comprising:
the host determines treatment time and irradiation distance according to the input illumination parameters, and outputs corresponding light source control signals according to the input light sequencing irradiation modes, so that the irradiator generates parallel collimated and uniform light spots of at least one different peak wavelength of the light sequencing irradiation modes according to the light source control signals, and irradiates a treatment area of a treated person according to the treatment time under the irradiation distance; the illumination parameters include at least one peak wavelength of the irradiation light and an illumination energy density and an illumination power density of the irradiation light matched with a treatment area of a person to be treated;
The host machine prepares and outputs the atomized water particles containing oxygen so that the atomized water particles are sprayed to the treatment area of the person to be treated by the atomization spraying mechanism in the process that the treatment area of the person to be treated is irradiated by the irradiator.
As a preferred mode of the second aspect of the present invention, the light sequencing irradiation mode includes a first light sequencing irradiation mode, a second light sequencing irradiation mode, and a third light sequencing irradiation mode;
The first light sequencing irradiation mode is that irradiation light with a peak wavelength repeatedly irradiates a treatment area of a treated person continuously or in a segmented mode until reaching the preset irradiation energy density;
The second light sequencing irradiation mode is that at least two irradiation lights with different peak wavelengths are used for repeatedly irradiating the treatment area of the person to be treated in a continuous or sectional mode, when one of the irradiation lights reaches the preset irradiation energy density, the irradiation is stopped, and the other irradiation lights are used for continuously irradiating the treatment area of the person to be treated until all the irradiation lights reach the preset irradiation energy density;
The third light sequencing irradiation mode is that at least two irradiation light with different peak wavelengths circularly and alternately irradiate the treatment area of the treated person repeatedly continuously or in sections, when one irradiation light reaches the preset irradiation energy density, the irradiation is stopped, and the rest irradiation light continues to irradiate the treatment area of the treated person until all irradiation light reaches the preset irradiation energy density.
As a preferred mode of the second aspect of the present invention, the step of determining the irradiation distance according to the illumination parameter includes:
establishing a distance-illumination power density relation database of the illumination, wherein the distance-illumination power density relation database is used for indicating average values of illumination power densities of the illumination and a target surface under different distances;
And determining the irradiation distance according to the irradiation power density of the irradiation light in the irradiation parameters by adopting a linear interpolation method based on the distance-irradiation power density relation database.
The photodynamic and ultrasonic atomization composite treatment device and the treatment method provided by the embodiment of the invention have the advantages that the treatment time and the irradiation distance of a specific person to be treated are determined through the host according to the preset illumination parameters of the person to be treated, and corresponding light source control signals are output according to the preset light sequencing irradiation mode, so that the irradiator generates parallel collimated and uniform light spots of at least one different peak wavelength which meets the light sequencing irradiation mode, and the distance between the irradiator and the treatment area of the person to be treated is kept at the irradiation distance, and the treatment area of the person to be treated is irradiated according to the determined treatment time. Therefore, the invention can realize uniform irradiation of the treatment area of the person to be treated, and the irradiation light has similar height of the irradiation power density distribution curved surface in the treatment area of the person to be treated, has high light energy utilization rate and can effectively enhance the treatment effect; meanwhile, different treated persons and different treatment areas can be pertinently irradiated according to different irradiation distances, different treatment times, different light sequencing irradiation modes and the like, a personalized treatment scheme is realized, and a better treatment effect can be obtained.
In addition, the host machine is used for preparing the aerosol water particles containing oxygen, and the aerosol water particles are sprayed to the treatment area of the person to be treated in the process of irradiating the treatment area of the person to be treated by the irradiator, so that discomfort such as local temperature rise, skin dryness and burning and the like caused in the treatment process can be relieved, the enzymatic reaction speed of the precursor of the photosensitizer substance is effectively prevented from being reduced, the yield of singlet oxygen in the photodynamic reaction process is not influenced, and the photodynamic treatment effect can be further improved.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the description of the embodiments will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a block diagram of a photodynamic and ultrasonic atomization combined treatment device according to an embodiment of the present invention;
FIG. 2 is a schematic diagram showing an exploded structure of an irradiator in a combined photodynamic and ultrasonic atomization therapeutic apparatus according to an embodiment of the present invention;
fig. 3 is a schematic structural diagram of an irradiation light source of an irradiator in a photodynamic and ultrasonic atomization composite treatment device according to an embodiment of the present invention;
fig. 4 is a schematic structural diagram of a multispectral irradiation module in an irradiation light source of an irradiator in a photodynamic and ultrasonic atomization composite treatment device according to an embodiment of the present invention;
FIG. 5 is a schematic structural diagram of a solid state light emitting device with multiple spectrums adopted by a multiple spectrum irradiation module in an irradiation light source of an irradiator in a combined photodynamic and ultrasonic atomization treatment device according to an embodiment of the present invention;
FIG. 6 is a graph showing the comparison of the irradiation effect of an irradiator in a photodynamic and ultrasonic atomization composite treatment device and an irradiator in the prior art according to an embodiment of the present invention;
FIG. 7 is a block diagram of an embodiment of an atomization spraying process in a photodynamic and ultrasonic atomization combined therapy device according to an embodiment of the present invention;
FIG. 8 is a schematic diagram of an exploded structure of a spray mechanism in a combined photodynamic and ultrasonic spray treatment device according to an embodiment of the present invention;
Fig. 9 is a schematic diagram of a specific structure of a photodynamic and ultrasonic atomization combined treatment device according to an embodiment of the present invention;
FIG. 10 is a schematic flow chart of a method for combined photodynamic and ultrasonic atomization therapy according to an embodiment of the present invention;
FIG. 11 is a schematic diagram of control signals for turning on and off irradiation light with a peak wavelength in a first light sequencing irradiation mode in a sectional irradiation mode in a photodynamic and ultrasonic atomization composite treatment method according to an embodiment of the present invention;
FIG. 12 is a schematic diagram of control signals for turning on and off at least two irradiation lights with different peak wavelengths in a sectional irradiation mode in a photodynamic and ultrasonic atomization composite treatment method according to an embodiment of the present invention;
Fig. 13 is a schematic diagram of control signals for turning on and off at least two irradiation lights with different peak wavelengths in a sectional irradiation mode in a third light sequencing irradiation mode in a photodynamic and ultrasonic atomization composite treatment method according to an embodiment of the present invention.
Wherein, 201, an irradiator end cover, 202, a multispectral irradiation module, 202-1, a circuit board, 202-2, a multispectral solid-state light-emitting device, 203, a first optical lens array, 204, a second optical lens array, 205, a heat radiation fan, 206 and a spray tube, 206-1, a water inlet connector, 207, a water collector, 207-1, a water outlet connector, 207-2, an upper end cover, 207-3, a lower end cover, 207-4, a boss, 208, a micro water pump, 209, a sealing ring, 210, a nut, 211, a through hole, 212 and a small hole;
501. a package substrate 502, a reflective cup 503, a solid state light emitting element 504, an electrode 505, a microlens array;
901. Host computer, 902, irradiator, 903, automatic stop multi-joint suspension arm, 9031, upper arm, 9032, lower arm, 9033, wrist, 9034, terminal connection portion, 9035, D-shaped wire protection cover with circular ring, 904, supporting portion, 905, liquid crystal display, 906, IC card seat, 907, handle, 908, universal castor.
Detailed Description
In order that those skilled in the art will better understand the present invention, a technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in which it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present invention without making any inventive effort, shall fall within the scope of the present invention.
It should be noted that: like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further definition or explanation thereof is necessary in the following figures.
Because the treatment areas and lesion parts of different treated persons are different in depth in the organism, and the photosensitizers used by different treated persons are also greatly different, when different treated persons receive photodynamic treatment, if personalized treatment schemes cannot be realized for different treated persons and different treatment areas thereof in a targeted manner, that is, different treated persons irradiate according to different irradiation distances, different treatment times, different light sequencing irradiation modes of peak wavelength light and the like, better treatment effects are difficult to obtain.
Meanwhile, because the absorption rate and the scattering rate of photons are different from different tissues of a human body, the tissues are penetrated by light with different peak wavelengths to different depths, and a photosensitizer used in actual photodynamic therapy often has a plurality of absorption spectrum peaks, so that the combined irradiation of the light with a plurality of peak wavelengths is selected in the photodynamic therapy, and the obtained therapeutic effect is generally better than that of the light with a single peak wavelength. In addition, if the light scattering angles of the LED chips with different peak wavelengths in the irradiation light source for generating the irradiation light are different, the shape of the curved surface of the irradiation power density distribution of the light with different peak wavelengths in the treatment area of the person to be treated is greatly different, so that the light energy utilization rate is low and the irradiation is uneven, and the effect of the photodynamic multispectral combined treatment using a plurality of LEDs with different peak wavelengths as the light sources is poor.
In addition, in the photodynamic therapy process, the skin of the treatment area is dehydrated to a certain extent under the action of the photosensitizer or the precursor of the photosensitizer substance and the irradiation of the irradiation light, and meanwhile, the irradiation of the irradiation light causes local temperature rise on the surface of the skin, so that discomfort such as skin dryness, burning and the like is caused. In addition, some of the precursors of photosensitizer substances widely used clinically are not photosensitive, and the precursors are synthesized into human endogenous photosensitizer protoporphyrin PpIX substances through enzymatic reaction to exert the photosensitization effect, and factors such as temperature rise, dehydration and the like can cause the reduction of the enzymatic reaction speed, so that the quantity of synthesized endogenous photosensitizer is reduced, thereby influencing the effect and application of photodynamic therapy.
The embodiment of the invention discloses a photodynamic and ultrasonic atomization composite treatment device, which is shown by referring to fig. 1 and mainly comprises:
the host computer is used for determining treatment time and irradiation distance according to preset illumination parameters and outputting corresponding light source control signals according to a preset light sequencing irradiation mode; also used for preparing the atomized water particles containing oxygen;
the irradiator is connected with the host computer and is used for receiving the light source control signals, generating parallel collimated irradiation light with uniform light spots meeting at least one different peak wavelength of the light sequencing irradiation mode, and irradiating a treatment area of a person to be treated according to the treatment time under the irradiation distance;
And the atomization spraying mechanism is connected with the host machine and is used for receiving the atomized water particles and spraying the atomized water particles to the treatment area of the person to be treated.
In the embodiment, a host and an irradiator are respectively arranged, then the treatment time and the irradiation distance of a person to be treated are determined through the host according to the illumination parameters preset for the person to be treated, and corresponding light source control signals are output to the irradiator according to the light sequencing irradiation mode preset for the person to be treated; the irradiator generates parallel collimated and uniform light spots of at least one different peak wavelength satisfying the light sequencing irradiation mode, and irradiates the treatment area of the person to be treated according to the determined treatment time when the distance between the irradiator and the treatment area of the person to be treated is kept at the irradiation distance. The host machine can also prepare atomized water particles containing oxygen.
Therefore, the uniform irradiation of the treatment area of the person to be treated is realized, the irradiation power density distribution curved surfaces of the irradiation light in the treatment area of the person to be treated are similar in height, the light energy utilization rate is high, and the treatment effect can be effectively enhanced; meanwhile, different treated persons and different treatment areas can be pertinently irradiated according to different irradiation distances, different treatment times, different light sequencing irradiation modes and the like, a personalized treatment scheme is realized, and a better treatment effect can be obtained.
Meanwhile, an atomization spraying mechanism is also arranged, and is used for receiving the atomized water particles containing oxygen output by the host, spraying the atomized water particles to the treatment area of the person to be treated in the irradiation process of the irradiator to the treatment area of the person to be treated, so that discomfort such as local temperature rise, skin dryness and burning and the like caused in the treatment process can be relieved, the enzymatic reaction speed of the precursor of the photosensitizer substance can be effectively prevented from being reduced, the yield of singlet oxygen in the photodynamic reaction process is not influenced, and the photodynamic treatment effect can be further improved.
Preferably, according to an embodiment of the present invention, the host includes a man-machine interaction unit, a decision control unit, a light source driving unit and an atomization generating unit, wherein the man-machine interaction unit, the light source driving unit and the atomization generating unit are respectively connected with the decision control unit, and the decision control unit and the atomization generating unit are also respectively connected with the atomization spraying mechanism.
Specifically, the host comprises a shell, the man-machine interaction unit is arranged on the shell, and the decision control unit, the light source driving unit and the atomization generation unit are all arranged in the shell. The man-machine interaction unit is a multimedia module, a liquid crystal display screen for displaying is arranged on the man-machine interaction unit, and a touch screen serving as touch key input is arranged on the liquid crystal display screen. The liquid crystal display is connected with the decision control unit through the UART, so that the man-machine interaction function of the host is realized. The touch screen can be used for inputting preset illumination parameters and light sequencing irradiation modes of different treated persons.
The decision control unit is a control core of the whole host, and other units in the host are connected with the decision control unit. In the whole photodynamic therapy process, on one hand, the decision control unit is used for determining the irradiation distance between the irradiator and the therapeutic area of the person to be treated to form a light sequencing irradiation mode for realizing better photodynamic effect, light source control signals of light sources with different corresponding peak wavelengths are generated, the light with the corresponding peak wavelengths from the irradiator irradiates the therapeutic area of the person to be treated, the distance detection is carried out in real time, and the light is displayed on the liquid crystal display screen of the man-machine interaction unit, so that a user is prompted to adjust the irradiator to the irradiation distance determined by the decision control unit; on the other hand, the decision control unit controls the atomization generation unit to generate the atomized water particles containing oxygen, and the atomized water particles are sprayed to the treatment area of the person to be treated by the atomization spraying mechanism.
The decision control unit adopts ARM series microprocessor, and is preloaded with embedded system of WinCE operation system. The 3 output bits of the general I/O interface of the microprocessor are used as control signals for turning on and off the irradiation light with different peak wavelengths after being subjected to photoelectric isolation, and then the control signals are transmitted to the irradiator through the light source driving unit, so that the turning on and off of each LED chip are controlled through different electrodes, and the corresponding peak wavelength light from the irradiator irradiates the treatment area of a person to be treated.
Further, the host also comprises an IC card management unit and a communication unit, wherein the IC card management unit and the communication unit are respectively connected with the decision control unit; the IC card management unit is used for recording illumination parameters and light sequencing irradiation modes of a person to be treated when the person to be treated is treated for the first time, and the communication unit is used for establishing communication connection with an external intelligent terminal or server.
Specifically, the IC card management unit and the communication unit are also provided inside the housing, both of which are connected to the decision control unit. The structure of the IC card management unit is realized by adopting a common existing technical scheme, and is not described herein. When in first treatment, the IC card management unit records illumination parameters and light sequencing irradiation modes set for different treated persons on the human-computer interaction unit on one IC card, and the subsequent treatment in the course of treatment can be directly carried out by using the content recorded on the IC card without inputting through the human-computer interaction unit again.
The communication unit adopts a USR-C215UART-WiFi module, and the module integrates the functions of MAC, a fundamental frequency chip, a radio frequency transceiver unit, a power amplifier and the like on hardware, supports a WIFI protocol and a TCP/IP protocol, and realizes the functions of establishing communication connection, data transmission and the like between a host and an external intelligent terminal or server.
On the basis of the above-described embodiments, referring to fig. 2 to 4, the irradiator includes an irradiator end cap 201 and an irradiation light source disposed below the irradiator end cap 201; the irradiation light source comprises a multispectral irradiation module 202, a first optical lens array 203 and a second optical lens array 204 which are sequentially arranged in parallel; the multispectral illumination module 202 comprises a circuit board 202-1 and at least one multispectral solid-state light-emitting device 202-2 capable of generating parallel collimated light beams with different peak wavelengths and uniform light spots, wherein the multispectral solid-state light-emitting devices 202-2 are arranged on the circuit board 202-1 in an orthogonal array; one side of the first optical lens array 203, which is provided with a plurality of refraction type small lenses arranged in an orthogonal array, faces towards the multispectral illumination module 202, one side of the second optical lens array 204, which is provided with a plurality of refraction type small lenses arranged in an orthogonal array, faces away from the multispectral illumination module 202, and each small lens on the second optical lens array 204 is overlapped with the center of each small lens on the first optical lens array 203 and corresponds to each side one by one; the distance between the multispectral irradiation module 202 and the first optical lens array 203 is 3-5 mm, and the distance between the first optical lens array 203 and the second optical lens array 204 is 0.85-1.15 times of the focal length of the lenslets.
In this embodiment, the multispectral illumination module in the illumination source is configured to generate illumination light for photodynamic therapy, which is disposed on a side near the end cap of the applicator.
Preferably, at least one cooling fan 205 is further disposed between the multispectral illumination module 202 and the end cover 201 of the irradiator, so as to dissipate heat of the multispectral illumination module, and further effectively avoid discomfort of a patient caused by heat generated by the multispectral illumination module.
In the multispectral illumination module, at least one multispectral solid-state light-emitting device which can generate parallel collimated light beams with different peak wavelengths and has uniform light spots is arranged on a circuit board in an orthogonal array. After the arrangement, a plurality of multispectral solid-state light emitting devices form a surface light source, each multispectral solid-state light emitting device generates a plurality of parallel collimated beamlets with different peak wavelengths and uniform light spots, so that the whole multispectral irradiation module can generate independent parallel beamlets with the same quantity as that of the multispectral solid-state light emitting devices, each beamlet consists of a plurality of beamlets, gaps exist among the beamlets, and the beamlets form a wide beam, thereby being capable of providing enough illumination power density for photodynamic therapy; the wide light beam generated by the multispectral irradiation module is sequentially output through the first optical lens array and the second optical lens array, so that uniform irradiation of a treatment area of a person to be treated is realized.
In practical application, the distance between the multispectral irradiation module and the first optical lens array is set to be 3-5 mm, so that the requirements of practical application and assembly process can be met. The distance between the first optical lens array and the second optical lens array is 0.85-1.15 times of the focal length of the small lens, namely the second optical lens array is arranged in parallel near the rear focal plane of the first optical lens array.
Specifically, the lenslets on the first optical lens array and the second optical lens array are regular hexagons or rectangles, so that seamless and compact arrangement of the lenslets on the first optical lens array and the second optical lens array can be realized.
Specifically, the distance between the first optical lens array and the second optical lens array is the same as the focal length of the lenslets, so that the spot uniformity effect of the light irradiated on the treatment area of the subject can be optimized.
The first optical lens array and the second optical lens array may be fabricated from a material having good light transmission in the wavelength range from visible to infrared, such as a polymethyl methacrylate material.
In addition, in practical application, the multiple multispectral irradiation modules can be closely arranged to form a plane or cambered surface photodynamic therapy light source, so that the effective irradiation area is larger, and the first optical lens array and the second optical lens array which are correspondingly arranged are also planes or cambered surfaces. And if the multispectral irradiation modules are closely arranged to form an arc surface, the arc surface curvature of the first optical lens array and the second optical lens array is the same as the arc surface curvature of the arc surface formed by the multispectral irradiation modules.
On the basis of the above embodiment, referring to fig. 5, the multi-spectrum solid state light emitting device includes a package substrate 501, a reflective cup 502 is disposed on a carrying surface of the package substrate 501, and at least two solid state light emitting elements 503 with different peak wavelengths are disposed in an accommodating space of the reflective cup 502; at least two pairs of electrodes 504 are arranged on two sides of the packaging substrate 501, the electrodes 504 are connected with the positive electrode and the negative electrode of the solid-state light-emitting element 503, and the electrodes 504 are also connected with a host; the light outlet of the reflecting cup 502 is further provided with a micro lens array 505 in a sealing manner, the micro lens array 505 is parallel to the packaging substrate 501, and one side of the micro lens array 505, which is provided with a plurality of refractive hemispherical micro lenses arranged in an orthogonal array, faces away from the solid-state light-emitting element 503.
In this embodiment, the above-mentioned multispectral solid-state light emitting device does not use transparent materials such as epoxy resin or silica gel to fill the reflective cup, but a micro lens array is arranged at the light outlet of the reflective cup in a sealing manner, and the size of the micro lens array is slightly larger than that of the light outlet of the reflective cup, so that the micro lens array can completely cover the light outlet of the reflective cup, the distance between the micro lens array and each solid-state light emitting element is fixed, and each solid-state light emitting element is isolated from the outside air, and the structure of the whole device is more compact, and is convenient for production and use. By this arrangement, each solid state light emitting element can be directly exposed to the air, and thus the etendue can be reduced. The optical expansion of the solid-state light-emitting element is increased by n 2 times by adopting a mode of packaging the solid-state light-emitting element by adopting a transparent material with the refractive index of n.
Compared with two packaging structures in the prior art, namely, a plane packaging structure is adopted or a hemispherical lens structure is additionally arranged on the light emergent surface of the plane packaging structure, the micro lens array arranged in the multispectral solid-state light-emitting device obviously reduces the thickness of the lens, and therefore, the energy loss of light rays in the lens is greatly reduced. Therefore, the microlens array is packaged at the light outlet of the reflecting cup, so that the problem of light extraction efficiency of the multispectral solid-state light-emitting device is solved, the space angles of the light rays with different wavelengths can be restrained to be approximately the same, large light spots with uniform illumination power density distribution and consistent positions are formed, and the clinical effect of photodynamic therapy can be effectively improved.
Meanwhile, the microlens array can collect light rays emitted by each solid-state light-emitting element in a large-angle light-emitting range and form a plurality of collimated parallel beamlets, the number of which is the same as that of the microlenses on the microlens array. As a result of this processing, although the spatial positions of the solid-state light-emitting elements provided on the same package substrate are different, light rays of different wavelengths incident thereto can be approximately regarded as point light sources from the same position for each microlens on the microlens array. Therefore, after the light rays emitted by the solid-state light-emitting elements are collimated by the micro-lens array, the spatial angular distribution difference of the light rays with different peak wavelengths in the beamlets is restrained to be small, and the positions of light spots formed by the beamlets with different peak wavelengths in the treatment area of the person to be treated are close to the same. Because the micro lenses on the micro lens array are closely arranged, the light spots formed by a plurality of light beams on the treatment area of the person to be treated are mutually connected to form large light spots with uniform illumination power density distribution and consistent positions, and the clinical effect of photodynamic therapy can be effectively improved.
Generally, the light outlet of the reflecting cup is rectangular or circular, and the shape of the micro lens array is matched with the shape of the light outlet of the reflecting cup. In addition, the bottom surface of the reflecting cup is preferably consistent with the shape of the light outlet, and the height of the reflecting cup is the same as the focal length of the micro lens.
Preferably, the solid state light emitting element includes a red LED chip having a peak wavelength in a wavelength range of 620 to 630nm, a green LED chip having a peak wavelength in a wavelength range of 520 to 530nm, and a blue LED chip having a peak wavelength in a wavelength range of 460 to 470 nm.
Since the peak of the absorbance spectrum of most photosensitizers is 625nm or 525nm or 465nm, the solid state light emitting elements are preferably red LED chip, green LED chip and blue LED chip having peak wavelengths in the above wavelength ranges, respectively, which can satisfy the specific demands of most photodynamic therapy for the wavelength of light.
Further, three pairs of electrodes are arranged on two sides of the packaging substrate and are respectively connected with the positive electrode and the negative electrode of the red light LED chip, the green light LED chip and the blue light LED chip, and each electrode is also connected with a light source driving unit in the host, so that the on and off of each LED chip can be independently controlled, and each LED chip can be conveniently controlled during photodynamic therapy.
Preferably, according to an embodiment of the present invention, the radius of the microlens is 0.05 to 0.25mm, the focal length of the microlens is 0.8mm, and the distance between the circular bottom surfaces of the adjacent microlenses is 0mm.
When the radius of the micro lens array arranged at the light outlet of the reflecting cup is 0.05-0.25 mm, and the distance between the circle centers of the round bottom surfaces of the adjacent micro lenses is 0.1-0.5 mm, the light extraction efficiency improving effect is obvious. At this time, the distance d=0 mm between the circular bottom surfaces of the adjacent microlenses, and the effective aperture ratio [ pi r 2/(2r+d)2 ] ×100% of the microlens array had a value of 78.5%.
According to the above preferred microlens parameters, the microlens array is made of optical glass having good light transmittance for all light rays in the wavelength range from visible light to infrared light. Therefore, in the case where the distance between the radius of the above microlens and the circular bottom surface of the adjacent microlens is 0mm, the focal length of each microlens on the microlens array made of the material is 0.8mm.
Further, the irradiator also comprises a distance sensor and a distance detection circuit connected with the distance sensor, and the distance detection circuit is connected with the host.
Specifically, the irradiator is also provided with a distance sensor and a distance detection circuit connected with the distance sensor, so that the distance between the irradiator and the treatment area of the person to be treated can be detected in real time. The distance detection circuit is connected with the decision control unit in the host, so that the decision control unit in the host can detect the distance between the irradiator and the treatment area of the treated person in real time, prompt a user to timely adjust the distance between the irradiator and the treatment area of the treated person, and ensure that the irradiator can irradiate to the treatment area of the treated person under the determined irradiation distance so as to obtain a better treatment effect.
The distance sensor and the distance detection circuit adopt a digital micro laser ranging module, the ranging precision can reach +/-1.0 mm, and the real-time measured distance value is transmitted to the host computer in a BCD code format. The structures of the distance sensor and the distance detection circuit are all realized by adopting a common prior technical scheme, and are not repeated here.
Based on the structures of the irradiators according to the above embodiments, referring to fig. 6, fig. 6 is a graph showing the irradiation effect of the irradiator in the photodynamic therapy device according to the embodiment of the present invention and the irradiator in the prior art. Fig. 6 (a) is a picture taken after the irradiator in the above embodiment projects red light with a peak wavelength of 625nm to a white curtain with a distance of 50cm in a darkroom environment, and fig. 6 (b) is a picture taken after the multispectral solid-state light emitting device in the prior art is adopted to form a multispectral illumination light source module, and the first optical lens array and the second optical lens array are removed to form the irradiator further, so that the white curtain with a peak wavelength of 625nm is projected to the white curtain with a distance of 50cm in the same darkroom environment. The difference between the two is evident from fig. 6 (a) and fig. 6 (b), and the light spot on the white curtain is significantly improved from the view of both the illumination uniformity and the illumination intensity in fig. 6 (a) compared with fig. 6 (b).
On the basis of the above embodiment, referring to fig. 7, the atomization generating unit includes an ultrasonic atomization chamber, a liquid container, an air supply part, a heating part, an oxygen generating part, an electromagnetic valve, an ozone generating part and an output interface, wherein the liquid container and the air supply part are respectively arranged above and below the ultrasonic atomization chamber, the ultrasonic atomization chamber is connected with the heating part through a pipeline, the oxygen generating part is connected with the electromagnetic valve through a pipeline, the heating part and the electromagnetic valve are respectively connected with the output interface through a three-way joint, and the output interface is also connected with the atomization spraying mechanism; the ozone generating part is arranged on a pipeline of the electromagnetic valve connected with the three-way joint.
In this embodiment, the atomization generating unit is disposed in the housing of the host machine, and is mainly used for preparing atomized water particles containing oxygen. The structure mainly comprises the following steps:
The ultrasonic atomizing chamber atomizes liquid by utilizing an ultrasonic transducer, and the liquid can be purified water or clear water added with a small amount of fragrance substances. In order to increase the atomization yield and control the atomization mode, the embodiment of the invention adopts a double ultrasonic transducer structure, and each ultrasonic transducer is provided with an independent driving circuit to realize independent or simultaneous operation in a continuous or intermittent mode. In addition, be provided with magnetic levitation formula water level detection switch in the ultrasonic atomization room, when ultrasonic atomization room water level was less than preset value, automatic stop ultrasonic transducer's atomizing work to produce the water shortage warning through the liquid crystal display of man-machine interaction unit in the host computer. The atomization of the ultrasonic transducer is controlled by a driving circuit electrically connected with the ultrasonic transducer, and a control signal and a water shortage alarm signal are connected to a decision control unit in the host. Preferably, the maximum atomization capacity of the ultrasonic atomization chamber in the embodiment of the invention is 800ml/h.
The liquid container is used for containing liquid to be atomized and is positioned above the ultrasonic atomization chamber, and a liquid outlet is arranged at the lower part of the liquid container and is used for automatically supplementing the liquid to be atomized to the ultrasonic atomization chamber through the outlet. Preferably, the capacity of the liquid container in the embodiment of the present invention is 8L.
And the air supply part is used for generating air pressure and conveying atomized water particles generated by the ultrasonic atomization chamber to the atomization spraying mechanism in an atomized form. The air supply part is positioned below the ultrasonic atomization chamber and consists of a direct current fan and an air supply pipeline, and is connected with the ultrasonic atomization chamber through the air supply pipeline. In order to realize air quantity control, the invention adopts PWM to carry out speed regulation control on the direct current fan, and the rotating speed range of the fan is: 0-3800rpm. The PWM control signal of the fan is connected to a decision control unit in the host.
And the oxygen generating part is used for generating oxygen with purity higher than 90%, air in the extraction environment generates oxygen through a pressure swing adsorption oxygen generating principle, and the output oxygen is connected with the air inlet end of the electromagnetic valve through a pipeline. When the electromagnetic valve is opened, oxygen is output from the air outlet end of the electromagnetic valve, and the oxygen flow is 1.0-1.2l/min. The operation of the oxygen generating part is controlled by a decision control unit in a host machine which is electrically connected with the oxygen generating part, and a control signal of the electromagnetic valve is also connected to the decision control unit in the host machine.
An ozone generating section for generating ozone by electrochemical reaction of oxygen molecules by high-voltage discharge, comprising a high-lead glass discharge tube and a high-frequency high-voltage power supply for generating a high-voltage corona electric field by the discharge tube. One end of the high-lead glass discharge tube is connected to the electromagnetic valve through an air tube, and the other end of the high-lead glass discharge tube is connected with a three-way joint through an air tube. Oxygen from the oxygen-making part enters the high-lead glass discharge tube in the ozone generating part through the electromagnetic valve. During photodynamic therapy, the high-frequency high-voltage power supply is set to be in a closed state, so that the gas output from the other end of the high-lead glass discharge tube is still oxygen, the oxygen is mixed with the aerosol water particles from the ultrasonic atomization chamber through the three-way connector, the aerosol formed after mixing has higher oxygen concentration and oxygen partial pressure, the aerosol water particles mixed with the oxygen reach the output interface along the air pipe, and the aerosol water particles are further output to the atomization spraying mechanism through the air pipe to be sprayed to a treatment area. On the other hand, when ozone disinfection is needed, the high-frequency high-voltage power supply is set to be in an on state, and at the moment, the high voltage provided by the power supply enables the high-lead glass discharge tube to generate a high-voltage corona electric field, so that oxygen molecules in the high-lead glass discharge tube are subjected to electrochemical reaction, ozone gas is output at the other end of the high-lead glass discharge tube, and when the oxygen flow is 1.0-1.2l/min, the ozone content in the output gas is 80-75mg/l. The high-frequency high-voltage power supply on and off signals are also connected to a decision control unit in the host.
And the heating part is used for heating the gas passing through the air pipe, under the state that the ultrasonic transducer in the ultrasonic atomization chamber stops working, the air from the air supply part enters the air pipe of the heating part through the ultrasonic atomization chamber, the air is heated to form hot air, and the hot air is sprayed out through the atomization spraying mechanism after passing through all the air pipes, so that the drying of the condensed water retained on the inner wall of the air pipe is realized. The heating part comprises a section of circular tube made of a metal material with good heat conduction property, and a PTC heating element and an NTC temperature sensor for measuring temperature are arranged on the outer wall of the circular tube; one end of the round tube is connected with the air outlet of the ultrasonic atomization chamber through an air tube, and the other end of the round tube is connected with the three-way joint through an air tube. The control signal of the PTC heating element described above and the detection signal of the NTC temperature sensor are also connected to a decision control unit in the host.
Specifically, the air pipes for connecting the components adopt plastic rib reinforced hoses with the inner diameter of 20 mm.
On the basis of the above embodiment, referring to fig. 7 and 8, the atomizing spray mechanism includes a spray pipe 206, a water collector 207, and a micro water pump 208, a water inlet tap 206-1 is provided on one side of the spray pipe 206, a water outlet tap 207-1 is provided on one side of the water collector 207, and the micro water pump 208 is connected with the water inlet tap 206-1 and the water outlet tap 207-1 through water outlet pipes, respectively; the water collector 207 is sleeved on the lower end part of the spray pipe 206, the water collector 207 comprises a lower end cover 207-3 and an upper end cover 207-2, a horn-shaped boss 207-4 extending towards the upper end cover 207-2 is arranged on the lower end cover 207-3, and a plurality of U-shaped grooves are formed in the periphery of the boss 207-4, so that condensation water on the inner wall of the spray pipe 206 enters the water collector 207 through the U-shaped grooves.
In this embodiment, the atomization spraying mechanism is disposed in the irradiator, and is connected to the atomization generating unit in the host through an air pipe, and is mainly used for spraying the atomized water particles containing oxygen prepared by the atomization generating unit.
Specifically, the upper end of the spray pipe is provided with an air pipe for connecting an output interface of the atomization generating unit, and the lower end of the spray pipe sequentially passes through an irradiator end cover, a first optical lens array and a second optical lens array of the irradiator and then is in threaded connection with an upper end cover of the water collector. The water inlet of the miniature water pump is connected with a water inlet joint on the upper end cover of the water collector through a drain pipe, and the water outlet of the miniature water pump is connected with a water outlet joint on the spray pipe through a drain pipe. The other end of the water inlet connector is positioned in the spray pipe and is connected with a drain pipe, the drain pipe is sleeved in a gas pipe connected with the output interface of the atomization generation unit at the upper end of the spray pipe, and the drain pipe is also connected to a position close to the output interface of the atomization generation unit. Preferably, the drain pipes all adopt fluorine rubber pipes, and the inner diameter of the drain pipes is 3mm, and the outer diameter of the drain pipes is 5mm.
The condensed water body collected in the water collector is pumped by the miniature water pump through the drain pipe, flows into the air pipe connected with the output interface of the atomization generating unit at the upper end of the spray pipe after passing through the other drain pipe, so that the condensed water body discharged by the drain pipe sleeved in the air pipe can finally flow back into the ultrasonic atomization chamber of the atomization generating unit along the inner wall of the air pipe. The miniature water pump adopts a brushless peristaltic pump and is electrically connected with a decision control unit in the host.
Further, the water collector includes an upper end cap and a lower end cap, which are assembled in a tight fit manner. A round hole is formed in one side of the upper end cover, the drain connector is pressed in from the round hole in a tight fit mode, a cross groove is formed in the bottom of the extending end of the drain connector, the length of the extending end is equal to that of the upper end cover and the lower end cover after the upper end cover is assembled, the cross groove is just contacted with the bottom of the lower end cover, and therefore accumulated water in the water collector can be pumped by the miniature water pump. The lower end cover is provided with a horn-shaped boss extending towards the upper end cover, the outer diameter of the boss is about 1mm smaller than the inner diameter of one end of the spray pipe with threads, a plurality of U-shaped grooves are uniformly distributed on the periphery of the boss, the groove depth is preferably 0.7mm, thus a gas pipe connected with the upper end of the spray pipe and a condensation water body flowing down from the inner wall of the spray pipe enter the water collector through the U-shaped grooves, and atomized water particles in the spray pipe are output from a horn-shaped opening formed by the boss at the lower end of the water collector.
Preferably, the joint of the spray tube 206 and the irradiator is further provided with a nut 210 and a sealing ring 209, and the joint of the lower end of the spray tube 206 and the water collector 207 is also provided with the sealing ring 209, so that the seepage of the condensed water from the joint can be prevented, and the treatment experience of the person to be treated is affected.
With further reference to fig. 2, when the atomizing spray mechanism is disposed on the irradiator, besides the through holes 211 formed on the end cap 201 of the irradiator, a through hole 211 is formed in the center of each of the first optical lens array 203 and the second optical lens array 204, the three through holes 211 are coaxial in center, and the spray pipe 206 passes through the through holes 211 coaxial in center on the end cap 201, the first optical lens array 203 and the second optical lens array 204 of the irradiator from top to bottom and then is connected with the water collector 207. Two small holes 212 are further formed beside the through holes 211 of the first optical lens array 203 and the second optical lens array 204, and a drain pipe connected with the drain nozzle 207-1 on the water collector 207 sequentially passes through the small holes 212 and then is connected to a water inlet of the micro water pump 208 positioned on the irradiator end cover 201, and a water outlet of the micro water pump 208 is connected with the water inlet nozzle 206-1 on the spray pipe 206 through the drain pipe.
In summary, fig. 7 shows a specific implementation structure of the whole atomization spraying process, in which the atomization generating unit is disposed in the housing of the host machine, and the atomization spraying mechanism is disposed in the irradiator, and the two are connected through an air pipe. In photodynamic therapy, the atomized water particles containing oxygen generated by the atomization generating unit are delivered to the atomization spraying mechanism through the air pipe and sprayed to the treatment area irradiated by irradiation light. After the treatment process is finished, the miniature water pump in the atomization injection mechanism automatically pumps the condensed water in the water collector and returns the condensed water to the ultrasonic atomization chamber in the atomization generation unit through the air pipe; meanwhile, the condensation water body on the inner wall of each pipeline is dried by the heated air flow, and finally, the pipelines are disinfected and sterilized with strong oxidability by utilizing ozone, so that bacterial propagules and mildew spots on the inner wall of the pipeline are prevented from breeding.
After the water collector of the atomization spraying mechanism on the irradiator is removed, the water collector is subjected to the conditions that the ambient temperature is 15-35 ℃ and the relative humidity is 40-80%. The ultrasonic atomizing chamber was continuously operated at a maximum atomizing capacity of 800ml/h, and the total amount of the condensate dropped from the spray tube every 20 minutes was collected manually. The test results showed that the total amount of condensed water collected every 20 minutes was 10-13ml on average. According to the above test conclusion, preferably, the outer diameter of the water collector in the embodiment of the invention is 60mm, the height is 12mm, the capacity of the water collector is about 16ml, and during the operation of the ultrasonic transducer in the ultrasonic atomization chamber, the micro water pump is automatically started for 30 seconds every 20 minutes to drain the water collector, so that the overflow phenomenon of the water collector can be completely avoided.
In one implementation, based on the structure described in the above embodiments, with reference to fig. 9, the mainframe 901 and the irradiator 902 are connected by an automatic stop multi-joint suspension arm 903, and the automatic stop multi-joint suspension arm 903 is a connection arm having 6 damping joints, which is composed of an upper arm portion 9031, a lower arm portion 9032, a wrist portion 9033, and an end connection portion 9034, and is mechanically connected to the mainframe 901 by a support portion 904 rigidly fixed to the central top portion of the mainframe 901. The electrical control signals on the irradiator 902 are connected to the sockets on the top of the irradiator in a concentrated manner, and the sockets are electrically connected with the light source driving unit and the decision control unit in the host 901 through the conducting wires which are arranged on the automatic stop multi-joint suspension arm 903 and are provided with the annular D-shaped wire protection cover 9035. The atomized water particles containing oxygen generated by the atomization generation unit in the mainframe 901 are sent to an atomization spraying structure provided in the irradiator 902 through an air pipe.
In order to realize that the space posture of the irradiator 902 is adjusted without causing the distortion of an air pipe, two annular D-shaped wire protecting covers 9035 are respectively arranged below an upper arm portion 9031 and a lower arm portion 9032 of the automatic stop multi-joint suspension arm 903, one end of the air pipe is connected with a spray pipe on the irradiator 902, then the air pipe sequentially passes through the lower arm portion 9032 and an annular ring on the annular D-shaped wire protecting cover 9035 below the upper arm portion 9031, and the other end of the air pipe is connected with an output interface on a rear plate of a shell of the host 901.
A hydraulic damper is further disposed inside the lower arm portion 9032, and when the distance between the spatial posture of the irradiator 902 and the treatment region of the person to be treated is manually adjusted, the spatial posture of the irradiator 902 is automatically maintained due to the action of the hydraulic damper and the damping joint in the automatic stop multi-joint suspension arm 903, and no additional locking mechanism is required to lock the cantilever joint. The automatic blocking multi-joint suspension arm 903 can realize the adjustment of the irradiator 902 within the range of 50cm in height, 90 degrees in left and right rotation and 90 degrees in up and down pitching, thereby facilitating the treated person to receive the treatment in sitting or prone position, and simultaneously easily realizing the adjustment of the distance between the irradiator 902 and the treatment area of the treated person, so that the irradiator 902 is positioned at the position of the expected distance.
Further, a liquid crystal display 905 for displaying therapeutic parameters and states in the man-machine interaction unit, a touch screen for inputting therapeutic parameters provided on the liquid crystal display 905, and an IC card holder 906 of the IC card management unit are provided on the housing of the host 901.
Inside the main machine 901 housing, the atomization generating unit is heavy and thus is installed at the lower part inside the main machine 901 housing, and other units are installed at the upper part inside the main machine 901 housing, and the specific positions are determined according to the internal structure of the main machine 901 housing, which is not marked in the figure, and is not limited in this regard.
An electric control signal socket is further arranged on the rear plate of the host 901 shell, and the electric control signal socket is connected with the light source driving unit and the decision control unit in the host 901. In addition, the output interface is positioned at the upper part of the rear plate of the casing of the host 901, so that the condensation water body formed by the inner wall of each air pipe in the atomization generation unit can flow back into the ultrasonic atomization chamber along the inner wall of the air pipe under the action of gravity. The left and right sides of host 901 casing is provided with handle 907 respectively, and host 901 casing bottom is provided with universal castor 908, and wherein two universal castor 908 that are located the casing front portion have brake mechanism, make things convenient for the removal and the fixed position of whole device.
Based on the structure of the photodynamic and ultrasonic atomization composite treatment device described in the above embodiments, the embodiment of the present invention further provides a photodynamic and ultrasonic atomization composite treatment method, and referring to fig. 10, the method mainly includes:
1001. The host determines the treatment time and the irradiation distance according to the input illumination parameters, and outputs corresponding light source control signals according to the input light sequencing irradiation modes, so that the irradiator generates parallel collimated irradiation light with uniform light spots meeting at least one different peak wavelength of the light sequencing irradiation modes according to the light source control signals, and irradiates the treatment area of the treated person according to the treatment time under the irradiation distance; the illumination parameters include at least one peak wavelength of the illumination light and an illumination energy density and an illumination power density of the illumination light matched to the treatment region of the subject;
1002. the host computer prepares and outputs the atomized water particles containing oxygen so that the atomized water particles are sprayed to the treatment area of the person to be treated by the atomized spraying mechanism in the process that the treatment area of the person to be treated is irradiated by the irradiator.
In step 1001, in order to achieve a personalized treatment plan for different subjects and different treatment areas thereof in a targeted manner, that is, different subjects irradiate according to different irradiation distances, different treatment times, different light sequencing irradiation modes of peak wavelength light, and the like, so as to obtain a better treatment effect, the irradiation parameters and the light sequencing irradiation modes for the subjects need to be preset through a man-machine interaction unit in the host.
In particular, the illumination parameters include at least one peak wavelength of the illumination light and an illumination energy density and an illumination power density of the illumination light that match a treatment region of the subject.
Preferably, according to an embodiment of the present invention, the light sequencing irradiation mode includes a first light sequencing irradiation mode, a second light sequencing irradiation mode and a third light sequencing irradiation mode;
The first light sequencing irradiation mode is that irradiation light with a peak wavelength repeatedly irradiates a treatment area of a treated person continuously or in a segmented mode until reaching the preset irradiation energy density; the second light sequencing irradiation mode is that at least two irradiation lights with different peak wavelengths are used for repeatedly irradiating the treatment area of the treated person at the same time, when one of the irradiation lights reaches the preset irradiation energy density, the irradiation is stopped, and the other irradiation lights are used for continuously irradiating the treatment area of the treated person until all the irradiation lights reach the preset irradiation energy density; the third light sequencing irradiation mode is that at least two irradiation light with different peak wavelengths circularly and alternately irradiate the treatment area of the treated person repeatedly continuously or in sections, when one irradiation light reaches the preset irradiation energy density, the irradiation is stopped, and the rest irradiation light continues to irradiate the treatment area of the treated person until all irradiation lights reach the preset irradiation energy density.
After determining the peak wavelength of the irradiation light that enables the treatment area of the subject to achieve the preferable treatment effect, the irradiation power density of the irradiation light of the peak wavelength corresponds to the distance between the irradiator and the treatment area of the subject. Thus, the decision control unit in the host computer may determine the irradiation distance, i.e. the distance between the irradiator and the treatment area of the person to be treated, from the peak wavelength of the irradiation light and the irradiation power density of the irradiation light. Furthermore, the treatment time, that is, the time for which the irradiation unit irradiates the treatment region of the subject, can be determined based on the irradiation power density of the irradiation light and the irradiation energy density to be reached.
Preferably, in one possible implementation, the step of determining the irradiation distance from the illumination parameters may be implemented as follows:
S1, establishing a distance-illumination power density relation database of the illumination light, wherein the distance-illumination power density relation database is used for indicating average values of illumination power densities of the illumination light and a target surface of a target under different distances;
S2, determining the irradiation distance according to the irradiation power density of the irradiation light in the irradiation parameters by adopting a linear interpolation method based on the distance-irradiation power density relation database.
The illumination power densities of the illumination light due to the different peak wavelengths correspond to the distance between the applicator and the treatment area of the subject. The decision control unit in the host computer stores a distance-illumination power density relation database in advance, and the relation database is established according to the corresponding relation of the average value of the illumination power densities of the illumination light with different peak wavelengths in the uniform light spot area of the target surface under different illumination distances between the irradiator and the target surface, namely the illumination light with one peak wavelength corresponds to different illumination power densities respectively under different illumination distances.
The illumination power density refers to the total energy per unit illumination area per unit time in mW/cm2. The light power density is a fundamental parameter of PDT dosimetry, which determines the intensity of locally received photons of light, and is currently considered to be a critical factor in determining the efficacy of PDT. The illumination power density given by the photodynamic therapy device in the prior art generally refers to the illumination power density of the light source emergent position, in practical application, the illumination power density reaching the treatment area of the person to be treated is uncertain due to the difference of the distance between the light source and the irradiation part, and especially the illumination power density of the photodynamic therapy device for realizing adjustment of the illumination power density by changing the driving current of the light source varies. Although some photodynamic therapy devices set up light sensors or CCDs in the therapeutic area of the person to be treated to detect the illumination power density in real time, and then adjust the distance between the light source and the irradiation area by means of automatic or manual methods to make the measurement value of the illumination power density in the therapeutic area within the set value range, the scheme can realize the accurate control of the illumination power density in the therapeutic area of the person to be treated, but because the set light sensors or CCDs produce local illumination light shielding to the therapeutic area, the photodynamic therapy effect of the therapeutic area is affected, and the complexity of the device and the complexity of the use process are increased.
In this embodiment, by establishing the distance-illumination power density relation database, a linear interpolation method can be more accurately adopted to determine the corresponding irradiation distance according to the illumination power density corresponding to the irradiation light, so that the irradiator can irradiate the treatment area of the person to be treated under the determined irradiation distance, thereby obtaining a better treatment effect.
Specifically, the specific establishment process of the distance-illumination power density relation database can be performed with reference to the following processes:
The following parameters are defined:
Uniformity: ai=ei/Ep (1)
Uniformity coefficient: e=se/S (2)
Wherein Ei is the illumination power density of a spot on the target surface irradiated by light; ep is the peak value of the illumination power density in the light spot on the target surface of the light irradiation object; s is the total area of the light spot on the target surface irradiated by the light; se is the area of an area of which Ai is more than or equal to 0.85 in a facula on the target surface irradiated by light; the area ai.gtoreq.0.85 is defined as the uniform spot area.
Setting a target surface at a position 100mm away from an irradiation light emergent surface of the irradiator, respectively projecting red light with peak wavelength in a wavelength range of 620-630nm, green light with peak wavelength in a wavelength range of 520-530nm and blue light with peak wavelength in a wavelength range of 460-470nm to the target surface, and measuring the irradiation power density of light spots on the target surface by using a light irradiator.
Specifically, the target surface is divided into 10×10mm square measurement subareas, the measurement target is the geometric center point of each subarea, the illumination power density value of the measurement target is recorded as Ei, and the uniformity Ai of the measurement target is calculated according to the formula (1). And accumulating the illumination power density values Ei in the area with the Ai being more than or equal to 0.85, and taking an average value, wherein the value is calibrated as the illumination power density value of the surface of the irradiation part of the irradiation light with the corresponding peak wavelength when the distance is 100 mm. And changing the distance between the irradiation light emergent surface of the irradiator and the target surface of the target by taking 20mm as a distance increment, and repeating the process until the distance value is 300mm, thereby completing the calibration test. Through the above process, a distance-illumination power density relationship database was established in which the distance between the irradiator and the target surface of the target was varied from 100mm to 300mm in 20mm increments.
Because the solid-state light-emitting device adopted in the irradiator has the advantages of long service life and reduced light intensity, the distance-illumination power density relation database established by calibration measurement can be stored in the decision control unit in the host for a long time, and the accurate measurement of the average value of the illumination power densities of the illumination lights with different peak wavelengths in the treatment area of the person to be treated is indirectly completed through the measurement of the distance. In addition, when periodic inspection is performed, recalibration measurement and update can be performed on the distance-illumination power density relation database at the same time, so that accuracy of indirect measurement of the illumination power density average value is ensured, and the database after recalibration measurement is updated with an intelligent terminal or a server for establishing connection through a communication unit in a host.
After the treatment time and the irradiation distance of the person to be treated are determined, a decision control unit in the host outputs corresponding light source control signals according to a light sequencing irradiation mode, the light source control signals are transmitted to a light source driving unit, and on-off control is carried out on currents of independent constant current source circuits of all LED light sources in the irradiator connected with the light source driving unit, so that the irradiation light with different peak wavelengths is turned on and off.
The three light sequencing irradiation modes comprise two repeated continuous or segmented irradiation modes. Under the same illumination power density, the treated area of the treated person obtains the same illumination energy density, and the sectional irradiation mode needs more treatment time than the continuous irradiation mode. However, in the sectional irradiation mode, because the oxygen concentration of the tissue at the target part and surrounding blood vessels is higher, irradiation light irradiation can generate more sufficient singlet oxygen, so that a better photodynamic effect is obtained, and in addition, the sectional irradiation mode can reduce discomfort caused to a person to be treated by heat generated by a light source. Therefore, in practical application, in three light sequencing irradiation modes, a segmented irradiation mode is generally adopted for treatment.
Referring to fig. 11, fig. 11 is a schematic diagram of a control signal for turning on and off irradiation light with a peak wavelength in a first light sequencing irradiation mode in a sectional irradiation mode in a photodynamic and ultrasonic atomization composite treatment method according to an embodiment of the present invention. In the figure, T off is a dark period time during which the irradiation light is in an off state; t on is the lighting period time during which the irradiation light is in a lighting state under pulse width modulation; f is the frequency of pulse width modulation of the irradiated light; t on is the light irradiation time of pulse width modulation; t c is the treatment time required for the irradiation light of the peak wavelength to reach the preset irradiation energy density in the treatment area of the subject.
Wherein, the treatment time t c (unit: second) required for the treatment area of the person to be treated to reach the preset irradiation energy density, namely the treatment time required in the first light sequencing irradiation mode is calculated as follows:
tc=H0/[(E0×D1×D2)×1000] (3)
Wherein E 0 is the illumination power density of the irradiation light with the peak wavelength, the unit is mW/cm 2;H0 is the illumination energy density of the irradiation light with the peak wavelength, the unit is J/cm 2;D1 is the irradiation duty ratio of the irradiation light in pulse width modulation, D 1=ton×f;D2 is the bright cycle time duty ratio, and D 2=Ton/(Ton+Toff).
During the bright cycle time T on, the application of pulse width modulated output to the illumination of the illumination light is based on photodynamic reaction process mechanisms. Since the photosensitizer molecule in the ground state absorbs light energy exceeding the threshold, it transitions to the excited state, and the photosensitizer molecule in the excited state transitions to the triplet state and then decays back to the ground state. The photosensitizer molecules in the triplet state undergo oxidation-reduction reaction with oxygen molecules and release energy to form toxic substance singlet oxygen 1O2, which damages the lesion tissue or blood vessels around it to kill the lesion tissue. Accordingly, corresponding to the above-described photodynamic reaction process is that the irradiation energy t on×E0 generated by the irradiation light during t on needs to reach and exceed the light energy of the threshold required for the photosensitizer molecule to transit from the ground state to the excited state, whereas the irradiation of light is stopped during 1/f-t on, and the photosensitizer molecule in the excited state releases energy, forms singlet oxygen of the toxic substance and decays back to the ground state, thus cycling. In the embodiment of the present invention, it is preferable that the frequency f at which the irradiation light is pulse width modulated is fixed to 1.75KHz; the range of the light irradiation time t on of pulse width modulation is as follows: t on is less than or equal to 1/2f and less than or equal to 1/f. Specifically, t on can be set by a man-machine interaction unit in the host, and the pace is set to be 50usec.
The production of singlet oxygen 1O2 during the photodynamic reaction will consume the oxygen concentration in the tissue of the target site and surrounding blood vessels and excessive oxygen concentration consumption will reduce the yield of singlet oxygen 1O2 so that the photodynamic therapy effect cannot last, thus, in the light source control signal arrangement of on and off, each on-period time T on is followed by one off-period time T off to effect a segmented irradiation of the treatment area of the subject. The oxygen concentration of the tissue and surrounding blood vessels of the target part is effectively recovered from the body circulatory system by using the dark cycle time T off, so that sufficient singlet oxygen can be formed in the next irradiation, and a better treatment effect can be achieved. In the embodiment of the present invention, preferably, the bright period time T on ranges from 1.0 to 10.0sec; the dark period time T off ranges from 1.0 to 10.0sec. Specifically, the steps T on and T off can be set by the human-computer interaction unit in the host, and the set step size is 0.1sec.
During the sectional irradiation in the above-described first light sequencing irradiation mode, if the dark period time T off is set to zero and the pulse width modulated light irradiation time T on in the bright period is set to 1/f, continuous irradiation can be performed on the treatment region of the subject.
Since many photosensitizers have a plurality of characteristic absorption peaks in their absorption spectra, such as delta-aminolevulinic acid (5-ALA), which is widely used in clinic, delta-aminolevulinic acid does not have photosensitive properties in nature, and is synthesized into protoporphyrin PpIX substance of human endogenous photosensitizers by enzymatic reaction to exert photosensitization. The absorbance spectrum of protoporphyrin PpIX has absorption peaks at 410nm, 510nm, 545nm, 580nm and 630 nm. In photodynamic therapy, irradiation light with a plurality of peak wavelengths close to a plurality of absorption peaks of a protoporphyrin PpIX absorption spectrum is selected for combined irradiation therapy, so that better therapeutic effect than irradiation light with one peak wavelength can be obtained, and the required therapeutic time is shortened. Therefore, on the basis of the first light sequencing irradiation mode, a second light sequencing irradiation mode and a third light sequencing irradiation mode are further arranged, and the two modes are continuous or segmented irradiation of irradiation light with at least two different peak wavelengths to the treatment area of the person to be treated.
Referring to fig. 12, fig. 12 is a schematic diagram of control signals for turning on and off at least two peak wavelengths of irradiation light in a sectional irradiation mode in a photodynamic and ultrasonic atomization composite treatment method according to an embodiment of the present invention. In the figure, t c1 is the treatment time required for the irradiation light with the first peak wavelength to reach the preset irradiation energy density in the treatment area of the person to be treated, t c2 is the treatment time required for the irradiation light with the second peak wavelength to reach the preset irradiation energy density in the treatment area of the person to be treated, t c3 is the treatment time required for the irradiation light with the third peak wavelength to reach the preset irradiation energy density in the treatment area of the person to be treated, and t c is the treatment time required in the second light sequencing irradiation mode.
Wherein, the treatment time t c1 (unit: seconds) required for the first peak wavelength of the irradiation light to reach the preset irradiation energy density of the treatment region of the person to be treated, the treatment time t c2 (unit: seconds) required for the second peak wavelength of the irradiation light to reach the preset irradiation energy density of the treatment region of the person to be treated, the treatment time t c3 (unit: seconds) required for the third peak wavelength of the irradiation light to reach the preset irradiation energy density of the treatment region of the person to be treated, and the treatment time t c (unit: seconds) required in the second light sequencing irradiation mode are calculated as follows:
tc1=H10/[(E10×D1×D2)×1000] (4)
tc2=H20/[(E20×D1×D2)×1000] (5)
tc3=H30/[(E30×D1×D2)×1000] (6)
tc=Max(tc1,tc2,tc3) (7)
Wherein E 10、E20 and E 30 are the illumination power densities of the first peak wavelength of the illumination light, the second peak wavelength of the illumination light and the third peak wavelength of the illumination light respectively, and the units are mW/cm 2;H10、H20 and H 30 are the illumination energy densities of the first peak wavelength of the illumination light, the second peak wavelength of the illumination light and the third peak wavelength of the illumination light respectively, and J/cm 2.
After starting the photodynamic therapy in the second light sequencing irradiation mode, the decision control unit in the host machine accumulates the illumination energy density values of the irradiation light with different peak wavelengths, when the accumulated value of the illumination energy density value of the irradiation light with one peak wavelength reaches a preset value, the decision control unit stops the light source control signal of extinction of the irradiation light with the peak wavelength corresponding to the time, and so on until the accumulated time reaches a t c value.
In the light source control signals for turning on and off the irradiation light of different peak wavelengths in the second light sequencing irradiation mode shown in fig. 12, the irradiation light is pulse width modulated and outputted at a fixed frequency f during the light cycle time.
Referring to fig. 13, fig. 13 is a schematic diagram of control signals for turning on and off at least two kinds of irradiation light with peak wavelengths in a third light sequencing irradiation mode in a combined photodynamic therapy and ultrasonic atomization method according to an embodiment of the present invention. In the figure, t c1 is the treatment time required for the irradiation light with the first peak wavelength to reach the preset irradiation energy density in the treatment area of the person to be treated, t c2 is the treatment time required for the irradiation light with the second peak wavelength to reach the preset irradiation energy density in the treatment area of the person to be treated, t c3 is the treatment time required for the irradiation light with the third peak wavelength to reach the preset irradiation energy density in the treatment area of the person to be treated, and t c is the treatment time required in the third light sequencing irradiation mode.
Wherein, the treatment time t c1 (unit: seconds) required for the first peak wavelength of the irradiation light to reach the preset irradiation energy density of the treatment region of the person to be treated, the treatment time t c2 (unit: seconds) required for the second peak wavelength of the irradiation light to reach the preset irradiation energy density of the treatment region of the person to be treated, the treatment time t c3 (unit: seconds) required for the third peak wavelength of the irradiation light to reach the preset irradiation energy density of the treatment region of the person to be treated, and the treatment time t c (unit: seconds) required in the third light sequencing irradiation mode are calculated as follows:
tc1=H10/[(E10×D1×D2)×1000] (8)
tc2=H20/[(E20×D1×D2)×1000] (9)
tc3=H30/[(E30×D1×D2)×1000] (10)
tc=tc1+tc2+tc3 (11)
Wherein E 10、E20 and E 30 are the illumination power densities of the first peak wavelength of the illumination light, the second peak wavelength of the illumination light and the third peak wavelength of the illumination light respectively, and the units are mW/cm 2;H10、H20 and H 30 are the illumination energy densities of the first peak wavelength of the illumination light, the second peak wavelength of the illumination light and the third peak wavelength of the illumination light respectively, and J/cm 2.
After starting the photodynamic therapy in the third light sequencing irradiation mode, accumulating the illumination energy density values of the irradiation light with different peak wavelengths by a decision control unit in the host, stopping the light source control signal for extinguishing the irradiation light with the peak wavelength corresponding to the time when the accumulated value of the illumination energy density value of the irradiation light with one peak wavelength reaches a preset value, and so on until the accumulated time reaches a value t c.
In the light source control signals for turning on and off the irradiation light with different peak wavelengths in the third light sequencing irradiation mode of fig. 13, the irradiation light is output by pulse width modulation at the fixed frequency f during the light period time.
The host outputs corresponding light source control signals according to the light sequencing irradiation modes and sends the light source control signals to the irradiator. The irradiator generates parallel collimated irradiation light with uniform light spots meeting at least one different peak wavelength of the light sequencing irradiation mode according to the light source control signal, and irradiates the treatment area of the person to be treated according to the obtained treatment time by adjusting the distance between the irradiator and the treatment area of the person to be treated under the obtained irradiation distance. In photodynamic therapy, any one of the first, second or third light-sequencing irradiation modes described in the embodiments of the present invention may be preferably used depending on the photosensitizer used for photodynamic therapy and the disease to be treated. Specifically, if the photosensitizer used has only one characteristic absorption peak on the absorption spectrum chart or has other absorption peaks, but the peak value is very small compared with the characteristic absorption peak, it is obvious that it is most appropriate to select irradiation light with a peak wavelength close to the characteristic absorption peak of the photosensitizer based on the photodynamic and ultrasonic atomization composite treatment device according to the embodiment of the present invention and perform photodynamic treatment according to the first light sequencing irradiation mode.
And the endogenous photosensitizer protoporphyrin PpIX and the like are subjected to photodynamic therapy according to the second ordered irradiation mode or the third ordered irradiation mode, so that a better therapeutic effect can be obtained. According to the optical characteristics of the tissue, due to the difference of the scattering rate and the absorption rate of the tissue to the irradiation light, the penetration capacity of the irradiation light with different peak wavelengths in the tissue is different, and the penetration depth in the tissue is shallower when the wavelength of the irradiation light is smaller. In the second light sequencing irradiation mode, the irradiation light with each peak wavelength irradiates the treatment area of the person to be treated simultaneously in the bright period time, and oxygen concentration of the superficial and deep tissues of the skin is consumed while singlet oxygen is generated by oxidation-reduction reaction of photosensitizer molecules. Therefore, the second light-ordered irradiation pattern is more suitable for skin diseases where lesions such as solar keratosis, bowing disease, etc. are present in a deeper location in the living body than the third light-ordered irradiation pattern. In the third light-ordering irradiation mode, the irradiation light of each peak wavelength is alternately irradiated onto the treatment region of the subject during the bright period, the irradiation light of different peak wavelengths has a longer dark period, and the superficial tissue in the living body has enough time to recover the oxygen concentration thereof, so that the third light-ordering irradiation mode is more suitable for diseases such as acne vulgaris where lesions exist on the surface layer of the skin in the living body than the second light-ordering irradiation mode.
In step 1002, the atomized spraying mechanism receives the atomized water particles containing oxygen outputted by the host, and sprays the atomized water particles to the treatment area of the person to be treated in the process of irradiating the treatment area of the person to be treated by the irradiator, so as to reduce the discomfort such as local temperature rise, skin dryness and burning and the like caused in the treatment process, effectively prevent the enzymatic reaction speed of the precursor of the photosensitizer substance from being reduced, and simultaneously not affect the yield of singlet oxygen in the photodynamic reaction process, and further improve the photodynamic treatment effect.
The photodynamic and ultrasonic atomization composite treatment device and the treatment method provided by the embodiment of the invention can realize uniform irradiation of the treatment area of the treated person, and the irradiation light has high utilization rate of light energy and can effectively enhance the treatment effect due to the fact that the irradiation power density distribution curved surfaces of irradiation light in the treatment area of the treated person are highly similar; meanwhile, different treated persons and different treatment areas can be pertinently irradiated according to different irradiation distances, different treatment times, different light sequencing irradiation modes and the like, a personalized treatment scheme is realized, and a better treatment effect can be obtained. In addition, the host machine is used for preparing the aerosol water particles containing oxygen, and the aerosol water particles are sprayed to the treatment area of the person to be treated in the process of irradiating the treatment area of the person to be treated by the irradiator, so that discomfort such as local temperature rise, skin dryness and burning and the like caused in the treatment process can be relieved, the enzymatic reaction speed of the precursor of the photosensitizer substance is effectively prevented from being reduced, the yield of singlet oxygen in the photodynamic reaction process is not influenced, and the photodynamic treatment effect can be further improved.
It should be noted that, for simplicity of description, the above-described embodiments of the method are all described as a series of combinations of actions, but it should be understood by those skilled in the art that the present invention is not limited by the order of actions described. Further, those skilled in the art will appreciate that the embodiments described in the specification are presently preferred embodiments, and that the acts are not necessarily required for the present invention.
It should be noted that, the photodynamic and ultrasonic atomization composite treatment method provided by the embodiment of the present invention belongs to the same technical concept as the photodynamic and ultrasonic atomization composite treatment device described in the foregoing embodiment, and details not mentioned in the method embodiment may refer to the description in the foregoing device embodiment, and are not repeated herein.
In the foregoing embodiments of the present invention, the descriptions of the embodiments are emphasized, and for a portion of this disclosure that is not described in detail in this embodiment, reference is made to the related descriptions of other embodiments.
The foregoing description of the preferred embodiments of the invention is not intended to limit the invention to the precise form disclosed, and any such modifications, equivalents, and alternatives falling within the spirit and scope of the invention are intended to be included within the scope of the invention.
Claims (6)
1. A photodynamic and ultrasonic nebulization combined treatment device, the device comprising:
The host computer is used for determining treatment time and irradiation distance according to preset illumination parameters and outputting corresponding light source control signals according to a preset light sequencing irradiation mode; the illumination parameters include at least one peak wavelength of the irradiation light and an illumination energy density and an illumination power density of the irradiation light matched with a treatment area of a person to be treated; also used for preparing the atomized water particles containing oxygen;
The irradiator is connected with the host computer and is used for receiving the light source control signals, generating parallel collimated irradiation light with uniform light spots and at least one different peak wavelength meeting the light sequencing irradiation mode, and irradiating a treatment area of a person to be treated according to the treatment time under the irradiation distance; wherein the irradiator comprises an irradiator end cover and an irradiation light source arranged below the irradiator end cover; the irradiation light source comprises a multispectral irradiation module, a first optical lens array and a second optical lens array which are sequentially arranged in parallel, the multispectral irradiation module comprises a circuit board and at least one multispectral solid-state light emitting device capable of generating parallel collimated light beams with different peak wavelengths and uniform light spots, and each multispectral solid-state light emitting device is arranged on the circuit board in an orthogonal array; the multispectral solid-state light-emitting device comprises a packaging substrate, wherein a bearing surface of the packaging substrate is provided with a reflecting cup, and at least two solid-state light-emitting elements with different peak wavelengths are arranged in an accommodating space of the reflecting cup; at least two pairs of electrodes are arranged on two sides of the packaging substrate, the electrodes are connected with the anode and the cathode of the solid-state light-emitting element, and the electrodes are also connected with the host; a micro-lens array is also arranged at the light outlet of the reflecting cup in a sealing way, the micro-lens array is parallel to the packaging substrate, and one side of the micro-lens array, which is provided with a plurality of refraction type hemispherical micro-lenses arranged in an orthogonal array, faces away from the solid-state light-emitting element;
an atomization spraying mechanism connected with the host machine and used for receiving the atomized water particles and spraying the atomized water particles to a treatment area of a person to be treated;
Wherein the light sequencing irradiation mode comprises a first light sequencing irradiation mode, a second light sequencing irradiation mode and a third light sequencing irradiation mode; the first light sequencing irradiation mode is that irradiation light with a peak wavelength repeatedly irradiates a treatment area of a treated person continuously or in a segmented mode until reaching the preset irradiation energy density; the second light sequencing irradiation mode is that at least two irradiation lights with different peak wavelengths are used for repeatedly irradiating the treatment area of the person to be treated in a continuous or sectional mode, when one of the irradiation lights reaches the preset irradiation energy density, the irradiation is stopped, and the other irradiation lights are used for continuously irradiating the treatment area of the person to be treated until all the irradiation lights reach the preset irradiation energy density; the third light sequencing irradiation mode is that at least two irradiation light with different peak wavelengths circularly and alternately irradiate the treatment area of the treated person repeatedly continuously or in a segmented mode, when one irradiation light reaches the preset irradiation energy density, the irradiation is stopped, and the other irradiation light continues to irradiate the treatment area of the treated person until all the irradiation lights reach the preset irradiation energy density;
When the irradiation distance is determined according to the illumination parameters, firstly establishing a distance-illumination power density relation database of the irradiation light, wherein the distance-illumination power density relation database is used for indicating average values of the illumination power densities of the irradiation light and the target surface under different distances; then, based on the distance-illumination power density relation database, determining the irradiation distance according to the illumination power density of the irradiation light in the illumination parameters by adopting a linear interpolation method;
The specific establishment process of the distance-illumination power density relation database is carried out by referring to the following processes:
The following parameters are defined:
Uniformity: ai=ei/Ep (1);
Uniformity coefficient: e=se/S (2);
wherein Ei is the illumination power density of a spot on the target surface irradiated by light; ep is the peak value of the illumination power density in the light spot on the target surface of the light irradiation object; s is the total area of the light spot on the target surface irradiated by the light; se is the area of an area of which Ai is more than or equal to 0.85 in a facula on the target surface irradiated by light; the area with Ai equal to or more than 0.85 is defined as a uniform light spot area;
Setting a target surface at a position 100mm away from an irradiation light emergent surface of the irradiator, respectively projecting red light with peak wavelength in a wavelength range of 620-630nm, green light with peak wavelength in a wavelength range of 520-530nm and blue light with peak wavelength in a wavelength range of 460-470nm to the target surface, and measuring the illumination power density of light spots on the target surface by using a light irradiator; dividing a target surface into 10X 10mm square measurement subareas, taking a measurement target as a geometric center point of each subarea, marking an illumination power density value of the measurement target as Ei, and calculating uniformity Ai of the measurement target according to a formula (1); accumulating the illumination power density values Ei in the area with the Ai being more than or equal to 0.85, and taking an average value, wherein the value is the illumination power density value of the surface of the irradiation part when the irradiation light with the corresponding peak wavelength is 100mm away; changing the distance between the irradiation light emergent surface of the irradiator and the target surface of the target by taking 20mm as a distance increment, repeating the process until the distance value is 300mm, and completing the calibration test;
the irradiator is also provided with a distance sensor and a distance detection circuit connected with the distance sensor;
The main machine and the irradiator are connected through an automatic stopping multi-joint suspension arm, the automatic stopping multi-joint suspension arm is a connecting arm which consists of an upper arm part, a lower arm part, a wrist part and a tail end connecting part and is provided with 6 damping joints, the mechanical connection between the main machine and the main machine is realized through a supporting part rigidly fixed at the central top of the main machine, and a hydraulic damper is further arranged in the lower arm part.
2. The device of claim 1, wherein a side of the first optical lens array having a plurality of refractive lenslets arranged in an orthogonal array faces the multispectral illumination module, a side of the second optical lens array having a plurality of refractive lenslets arranged in an orthogonal array faces away from the multispectral illumination module, and each lenslet of the second optical lens array coincides with a center of each lenslet of the first optical lens array and each side corresponds one-to-one; the distance between the multispectral illumination module and the first optical lens array is 3-5 mm, and the distance between the first optical lens array and the second optical lens array is 0.85-1.15 times of the focal length of the small lens.
3. The device of claim 2, wherein the radius of the micro-lens is 0.05-0.25 mm, the focal length of the micro-lens is 0.8mm, and the distance between the round bottom surfaces of adjacent micro-lenses is 0mm.
4. The device according to any one of claims 1 to 3, wherein the host comprises a man-machine interaction unit, a decision control unit, a light source driving unit and an atomization generation unit, the man-machine interaction unit, the light source driving unit and the atomization generation unit are respectively connected with the decision control unit, and the decision control unit and the atomization generation unit are respectively connected with the atomization spraying mechanism.
5. The device according to claim 4, wherein the atomization generating unit comprises an ultrasonic atomization chamber, a liquid container, an air supply part, a heating part, an oxygen generating part, a solenoid valve, an ozone generating part and an output interface, wherein the liquid container and the air supply part are respectively arranged above and below the ultrasonic atomization chamber, the ultrasonic atomization chamber is connected with the heating part through a pipeline, the oxygen generating part is connected with the solenoid valve through a pipeline, the heating part and the solenoid valve are respectively connected with the output interface through a three-way joint through a pipeline, and the output interface is also connected with the atomization spraying mechanism; the ozone generating part is arranged on a pipeline of the electromagnetic valve connected with the three-way joint.
6. The device according to claim 1, wherein the atomizing and spraying mechanism comprises a spray pipe, a water collector and a miniature water pump, a water inlet connector is arranged on one side of the spray pipe, a water outlet connector is arranged on one side of the water collector, and the miniature water pump is connected with the water inlet connector and the water outlet connector through drain pipes respectively; the water collector is sleeved on the lower end part of the spray pipe and comprises a lower end cover and an upper end cover, a horn-shaped boss extending towards the direction of the upper end cover is arranged on the lower end cover, and a plurality of U-shaped grooves are formed in the periphery of the boss, so that condensation water on the inner wall of the spray pipe enters the water collector through the U-shaped grooves.
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