CN109675201A - A kind of optical power therapentic equipment and treatment method - Google Patents

A kind of optical power therapentic equipment and treatment method Download PDF

Info

Publication number
CN109675201A
CN109675201A CN201811566823.5A CN201811566823A CN109675201A CN 109675201 A CN109675201 A CN 109675201A CN 201811566823 A CN201811566823 A CN 201811566823A CN 109675201 A CN109675201 A CN 109675201A
Authority
CN
China
Prior art keywords
light
irradiation
patient
distance
illumination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201811566823.5A
Other languages
Chinese (zh)
Inventor
黄仁祥
黄雪晨
郭南萍
王小辉
边艳香
余小红
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangzhou Meirei Health Industry Co Ltd
Original Assignee
Guangzhou Meirei Health Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangzhou Meirei Health Industry Co Ltd filed Critical Guangzhou Meirei Health Industry Co Ltd
Priority to CN201811566823.5A priority Critical patent/CN109675201A/en
Publication of CN109675201A publication Critical patent/CN109675201A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0632—Constructional aspects of the apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0642—Irradiating part of the body at a certain distance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0664—Details

Abstract

It includes: host that the present invention, which provides a kind of optical power therapentic equipment and treatment method, the device, for determining treatment time and irradiation distance according to preset illumination parameter, and exports corresponding light source control signal according to preset light sequence irradiation mode；Irradiator, it connect with host, for receiving light source control signal, the parallel collimation and the uniform exposure light of hot spot for meeting at least one different peak wavelengths of light sequence irradiation mode are generated, and be irradiated according to treatment time to the treatment region of patient under irradiation distance.The Uniform Irradiation to the treatment region of patient can be achieved in the present invention, and illumination power density distribution curved surface height of the exposure light in the treatment region of patient is similar, and the efficiency of light energy utilization is high, can effectively enhance therapeutic effect；Meanwhile, it is capable to targetedly realize personalized therapeutic scheme to different patient and its different treatment region, preferable therapeutic effect can be obtained.

Description

A kind of optical power therapentic equipment and treatment method
Technical field
The present invention relates to field of photodynamic, and in particular to a kind of optical power therapentic equipment and treatment method.
Background technique
In recent years, optical dynamic therapy (PDT) is widely answered in the indications such as treatment skin diseases, medical cosmetology With.Wherein, the radiation source for the treatment of plays the role of very important in photodynamic therapy, how to select radiation source, simultaneously Optimization association illumination parameter forms light irradiation strategy over the course for the treatment of, and generating optimal photodynamic effect is optical dynamic therapy dress The popular research direction set.
However, there are some problems for optical power therapentic equipment in the prior art, it is each difference in radiation source first The light angle of scattering of the LED chip of wavelength is different, so that illumination power of the different wavelengths of light in patient treatment region is close Spend that distribution surface shape difference is very big, the efficiency of light energy utilization is low, uneven illumination is even, thus cause using multiple and different wavelength LED as The multispectral combination therapy of light power of light source it is ineffective；Secondly, in association illumination parameter, the upper primary limitation of light irradiation strategy In illumination power density, optical source wavelength, treatment time etc., regulating power is limited, cannot give full play to multispectral smooth power and control The advantage for the treatment of is unsuitable for realizing personalized therapeutic scheme.
Summary of the invention
The embodiment of the present invention provides a kind of optical power therapentic equipment and treatment method, to solve smooth power in the prior art Illumination power density distribution curved surface of the different peak wavelength light of radiation source in patient treatment region in therapeutic device Shape difference is very big, the efficiency of light energy utilization is low, uneven illumination is even, and is unsuitable for the problem of realizing personalized therapeutic scheme.
In a first aspect, the embodiment of the present invention provides a kind of optical power therapentic equipment, described device includes:
Host for determining treatment time and irradiation distance according to preset illumination parameter, and sorts according to preset light Irradiation mode exports corresponding light source control signal；
Irradiator is connect with the host, and for receiving the light source control signal, generation meets the light sequence spoke According to the parallel collimation and the uniform exposure light of hot spot of at least one different peak wavelengths of mode, and pressed under the irradiation distance It is irradiated according to the treatment time to the treatment region of patient.
As the preferred embodiment of first aspect present invention, the irradiator includes irradiator end cap and is arranged in the spoke According to the radiation source below device end cap；
The radiation source includes successively multispectral irradiation mould group, the first optical lens array and the second light disposed in parallel Learn lens array；The multispectral irradiation mould group includes wiring board and at least one can generate the parallel of different peak wavelengths The multispectral Sony ericsson mobile comm ab of collimation and the uniform light beam of hot spot, each multispectral orthogonal thereto array row of Sony ericsson mobile comm ab Cloth is on the wiring board；There is the refractive lenslet of multiple orthogonal thereto array arrangements on first optical lens array Side is towards the multispectral irradiation mould group, with the refraction of multiple orthogonal thereto array arrangements on second optical lens array Each lenslet of the side of type lenslet in the multispectral irradiation mould group, second optical lens array and described the The center of each lenslet on one optical lens array is overlapped and each side corresponds；The multispectral irradiation mould group and described the The distance of one optical lens array is 3~5mm, and first optical lens array is at a distance from second optical lens array It is 0.85~1.15 times of the focal length of the lenslet.
As the preferred embodiment of first aspect present invention, the multispectral Sony ericsson mobile comm ab includes package substrate, described It is provided with reflector on the loading end of package substrate, at least two different peak value waves are provided in the accommodation space of the reflector Long solid-state light emitting element；The package substrate two sides are provided at least two pairs of electrodes, the electrode and solid luminescent member The positive and negative anodes of part are connected, and the electrode is also connect with the host；Also closed off at the light-emitting window of the reflector be provided with it is micro- Lens array, the microlens array is parallel with the package substrate, and has multiple orthogonal thereto arrays on the microlens array The side of the refractive hemispherical microlenses of arrangement is backwards to the solid-state light emitting element.
As the preferred embodiment of first aspect present invention, the radius of the lenticule is 0.05~0.25mm, described micro- The focal length of mirror is 0.8mm, and the distance between rounded bottom surface of the adjacent lenticule is 0mm.
As the preferred embodiment of first aspect present invention, the irradiator further include range sensor and with the distance Sensor connection apart from detection circuit, it is described to be connect apart from detection circuit with the host.
As the preferred embodiment of first aspect present invention, the host include man-machine interaction unit, Decision Control unit and Light source driving units, the man-machine interaction unit and the light source driving units are connect with the Decision Control unit respectively, institute Light source driving units are stated also to connect with the irradiator；Wherein, the man-machine interaction unit for input the illumination parameter and The light sorts irradiation mode, and the Decision Control unit is used to determine treatment time and described according to the illumination parameter Irradiation distance, and so that the light source driving units is exported corresponding light source to the irradiator according to light sequence irradiation mode Control signal.
As the preferred embodiment of first aspect present invention, the host further includes IC card administrative unit and communication unit, institute IC card administrative unit and the communication unit is stated to connect with the Decision Control unit respectively；Wherein, the IC card management is single Member for for the first time treat when record patient illumination parameter and light sort irradiation mode, the communication unit be used for it is outer The intelligent terminal or server in portion establish communication connection.
Second aspect, the embodiment of the present invention provide a kind of photodynamic-therapeutic method, which comprises
Host receives the preset illumination parameter of input and light sequence irradiation mode, the illumination parameter include at least one The light energy density and light of the peak wavelength of exposure light and the exposure light to match with the treatment region of patient According to power density；
According to the illumination parameter, treatment time and irradiation distance are determined, and according to light sequence irradiation mode output Corresponding light source control signal；
The light source control signal is sent to irradiator, so that the irradiator is generated according to the light source control signal Meet the parallel of at least one different peak wavelengths of light sequence irradiation mode to collimate and the uniform exposure light of hot spot, and It is irradiated according to the treatment time to the treatment region of patient under the irradiation distance.
As the preferred embodiment of second aspect of the present invention, the light sequence irradiation mode includes the first light sequence irradiation mould Formula, the second light sequence irradiation mode and third light sequence irradiation mode；
The first light sequence irradiation mode is that a kind of exposure light of peak wavelength carries out the treatment region of patient Duplicate continuous or segmentation irradiation, until stopping when reaching its preset light energy density；
The second light sequence irradiation mode is the exposure light of at least two different peak wavelengths simultaneously to patient Treatment region carries out duplicate continuous or segmentation irradiation, stops when one of exposure light reaches its preset light energy density It only irradiates, remaining exposure light continues to be irradiated the treatment region of patient, presets until all exposure lights reach it Light energy density when stop irradiation；
The third light sequence irradiation mode is the exposure light cycle alternation of at least two different peak wavelengths to treated The treatment region of person carries out duplicate continuous or segmentation irradiation, when one of exposure light reaches its preset light energy density When stop irradiation, remaining exposure light continues to be irradiated the treatment region of patient, until all exposure lights reach it Stop irradiation when preset light energy density.
As the preferred embodiment of second aspect of the present invention, the step of determining irradiation distance according to the illumination parameter, includes:
Establish distance-illumination saturation effect database of the exposure light, the distance-illumination saturation effect Database is used to indicate the exposure light and illumination power density average value of the target target surface under different distance；
Based on the distance-illumination saturation effect database, using linear interpolation method according to the illumination parameter Described in the illumination power density of exposure light determine the irradiation distance.
A kind of optical power therapentic equipment provided in an embodiment of the present invention and treatment method, by host according to for specific quilt The preset illumination parameter of curer determines treatment time and the irradiation distance of the patient, and sorts and irradiate according to preset light Mode exports corresponding light source control signal, so that irradiator be made to generate the different peaks of at least one for meeting light sequence irradiation mode Be worth wavelength it is parallel collimation and the uniform exposure light of hot spot, and between treatment region of the irradiator with patient at a distance from guarantor It holds under irradiation distance, is irradiated according to the treatment time determined to the treatment region of patient.Therefore, the present invention can Realize the Uniform Irradiation to the treatment region of patient, and illumination power of the exposure light in the treatment region of patient is close It is similar to spend distribution surface height, efficiency of light energy utilization height can effectively enhance therapeutic effect；Meanwhile, it is capable to targetedly to not With patient and its different treatment region according to different irradiation distances, different treatment times and the irradiation mode that sorts of not sharing the same light Etc. being irradiated, realizes personalized therapeutic scheme, preferable therapeutic effect can be obtained.
Detailed description of the invention
To describe the technical solutions in the embodiments of the present invention more clearly, make required in being described below to embodiment Attached drawing is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the invention, for For those of ordinary skill in the art, without creative efforts, it can also be obtained according to these attached drawings other Attached drawing.
Fig. 1 is a kind of structural block diagram of optical power therapentic equipment provided in an embodiment of the present invention；
Fig. 2 is the decomposition texture schematic diagram of irradiator in a kind of optical power therapentic equipment provided in an embodiment of the present invention；
Fig. 3 is the structural representation of the radiation source of irradiator in a kind of optical power therapentic equipment provided in an embodiment of the present invention Figure；
Fig. 4 is multispectral in the radiation source of irradiator in a kind of optical power therapentic equipment provided in an embodiment of the present invention Irradiate the structural schematic diagram of mould group；
Fig. 5 is multispectral in the radiation source of irradiator in a kind of optical power therapentic equipment provided in an embodiment of the present invention Irradiate the structural schematic diagram for the multispectral Sony ericsson mobile comm ab that mould group uses；
Fig. 6 is irradiator and irradiator in the prior art in a kind of optical power therapentic equipment provided in an embodiment of the present invention Radiation response comparison diagram；
Fig. 7 is a kind of structural schematic diagram of optical power therapentic equipment provided in an embodiment of the present invention；
Fig. 8 is a kind of flow diagram of photodynamic-therapeutic method provided in an embodiment of the present invention；
Fig. 9 is a kind of in the case where the first light sorts irradiation mode in a kind of photodynamic-therapeutic method provided in an embodiment of the present invention The exposure light of peak wavelength is in the control signal schematic representation lighted with extinguished being segmented under radiation mode；
Figure 10 be in a kind of photodynamic-therapeutic method provided in an embodiment of the present invention the second light sort irradiation mode down toward The exposure light of few two kinds of different peak wavelengths is in the control signal schematic representation lighted with extinguished being segmented under radiation mode；
Figure 11 be in a kind of photodynamic-therapeutic method provided in an embodiment of the present invention third light sort irradiation mode down toward The exposure light of few two kinds of different peak wavelengths is in the control signal schematic representation lighted with extinguished being segmented under radiation mode.
Wherein, 201, irradiator end cap, 202, multispectral irradiation mould group, 202-1, wiring board, 202-2, multispectral solid-state Luminescent device, the 203, first optical lens array, the 204, second optical lens array, 205, radiator fan；
501, package substrate, 502, reflector, 503, solid-state light emitting element, 504, electrode, 505, microlens array；
701, host, 702, irradiator, 703, automatic resistance stop multi-joint suspension arm, 7031, upper arm parts, 7032, lower arm part, 7033, wrist, 7034, terminal connection portion, 7035, D type shield irdome, 704, support portion, 705, liquid crystal display, 706, IC card Seat, 707, universal caster wheel.
Specific embodiment
In order to enable those skilled in the art to better understand the solution of the present invention, below in conjunction in the embodiment of the present invention Attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is only The embodiment of a part of the invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill people The model that the present invention protects all should belong in member's every other embodiment obtained without making creative work It encloses.
It should also be noted that similar label and letter indicate similar terms in following attached drawing, therefore, once a certain Xiang Yi It is defined in a attached drawing, does not then need that it is further defined and explained in subsequent attached drawing.
Since the treatment region of different patient is different with the depth position of diseased region in vivo, while not Also there is larger difference with the photosensitizer that patient uses, so that different patient are when receiving optical dynamic therapy, such as Fruit targetedly can not realize personalized therapeutic scheme to different patient and its different treatment region, i.e., different Patient according to different irradiation distances, different treatment times and different peak wavelength light light sequence irradiation mode etc. It is irradiated, is then difficult to obtain preferable therapeutic effect.
In addition, since absorptivity and scattered power of the human body different tissues to photon have differences, so that different peak wavelengths Light different penetration depthes is woven with to group, and the photosensitizer used in actual optical dynamic therapy is commonly present multiple absorption light Therefore spectrum peak selects the light of multiple peak wavelengths to carry out joint irradiation in optical dynamic therapy, acquired therapeutic effect is logical It is often better than the therapeutic effect of the light using single peak value wavelength.In addition, if generating each difference in the radiation source of exposure light The light angle of scattering of the LED chip of peak wavelength is different, can make different peak wavelength light in the treatment region of patient Illumination power density distribution curve form it is widely different, lead to that the efficiency of light energy utilization is low, uneven illumination is even, to cause with multiple Different peak wavelength LED as light source the multispectral combination therapy of light power it is ineffective.
The embodiment of the invention discloses a kind of optical power therapentic equipments, shown referring to Fig.1, the device mainly includes:
Host for determining treatment time and irradiation distance according to preset illumination parameter, and sorts according to preset light Irradiation mode exports corresponding light source control signal；
Irradiator is connect with host, and for receiving light source control signal, generation meets light sequence irradiation mode at least A kind of the parallel of difference peak wavelength collimates and the uniform exposure light of hot spot, and under irradiation distance according to treatment time to being controlled The treatment region for the treatment of person is irradiated.
In the present embodiment, it is respectively provided with host and irradiator, then by host according to pre- for specific patient If illumination parameter determine treatment time and the irradiation distance of the patient, and according to being directed to the preset light of specific patient The irradiation mode that sorts exports corresponding light source control signal to irradiator；Irradiator generation meets light sequence irradiation mode at least It is a kind of difference peak wavelength it is parallel collimate and the uniform exposure light of hot spot, and the treatment region of irradiator and patient it Between distance when being maintained at irradiation distance, be irradiated according to the treatment time determined to the treatment region of patient.
Therefore, the Uniform Irradiation to the treatment region of patient is realized, and exposure light is in the treatment of patient Illumination power density distribution curved surface height in region is similar, and the efficiency of light energy utilization is high, can effectively enhance therapeutic effect；Meanwhile Can targetedly to different patient and its different treatment region according to different irradiation distances, different treatment times and The irradiation mode etc. that sorts of not sharing the same light is irradiated, and is realized personalized therapeutic scheme, can be obtained preferable therapeutic effect.
Preferably, according to an embodiment of the invention, host includes man-machine interaction unit, Decision Control unit and light source driving Unit, man-machine interaction unit and light source driving units are connect with Decision Control unit respectively, light source driving units also with irradiator Connection；Wherein, man-machine interaction unit is used for for inputting illumination parameter and light sequence irradiation mode, Decision Control unit according to light Treatment time and irradiation distance are determined according to parameter, and make light source driving units to irradiator output phase according to light sequence irradiation mode The light source control signal answered.
Specifically, host includes a shell, and man-machine interaction unit is arranged on the housing, and Decision Control unit and light Source driving unit is arranged in the shell.Specifically, man-machine interaction unit is a multimedia mould group, be which is provided with for showing The liquid crystal display shown, and the touch screen inputted as touch key-press is installed on liquid crystal display.The liquid crystal display is logical It crosses UART to connect with Decision Control unit, realizes the human-computer interaction function of host.By the touch screen can input it is preset not With illumination parameter and light the sequence irradiation mode of patient.
Decision Control unit is the control core of entire host, remaining each unit in host is both needed to and Decision Control unit Connection.Decision Control unit determines irradiator according to illumination parameter and light the sequence irradiation mode obtained from man-machine interaction unit Irradiation distance between the treatment region of patient, and real-time perfoming distance detects and in the liquid crystal of man-machine interaction unit Show screen display, to prompt user that irradiator is adjusted in the irradiation distance that Decision Control unit determines.In turn, Decision Control When treatment needed for unit reaches its light energy density according to the exposure light that the illumination parameter of input calculates different peak wavelengths Between.
Decision Control unit uses ARM series microprocessor, pre-installs the embedded system of WinCE operating system, passes through UART is connect with human-computer interaction portion.3 output bits of general purpose I/O Interface of the microprocessor, as difference after Phototube Coupling The control signal of peak wavelength exposure light lighted with extinguished, is then transferred in irradiator by light source driving units, thus By different electrodes to each LED chip light and extinguishing controls, make the corresponding peaks wavelength light from irradiator It is irradiated to the treatment region of patient.
Preferably, according to an embodiment of the invention, host further includes IC card administrative unit and communication unit, IC card management is single Member and communication unit are connect with Decision Control unit respectively；Wherein, IC card administrative unit is used to record quilt when treating for the first time Illumination parameter and light the sequence irradiation mode of curer, communication unit are used to communicate with external intelligent terminal or server foundation Connection.
Specifically, the IC card administrative unit and communication unit are also disposed at enclosure interior, connect with Decision Control unit. The structure of the IC card administrative unit realizes that details are not described herein using usually existing technical solution.When treating for the first time, IC card Administrative unit will be directed to the illumination parameter and light sequence irradiation mode record of different patient setting from man-machine interaction unit Onto an IC card, the treatment in the subsequent course for the treatment of can directly content of the usage record in IC card be carried out, without again It is secondary to be inputted by man-machine interaction unit.
The communication unit use USR-C215UART-WiFi module, the module be integrated on hardware MAC, baseband chip, Transmit Receive Unit and power amplifier etc. support WIFI agreement and ICP/IP protocol, realize host and external intelligence Terminal or server establish the functions such as communication connection and data transmission.
On the basis of the above embodiments, referring to shown in Fig. 2~Fig. 4, irradiator includes irradiator end cap 201 and setting Radiation source below irradiator end cap 201；Radiation source includes successively multispectral irradiation mould group 202 disposed in parallel, the One optical lens array 203 and the second optical lens array 204；Multispectral irradiation mould group 202 is including wiring board 202-1 and extremely Few one can generate the parallel collimation of different peak wavelengths and the multispectral Sony ericsson mobile comm ab 202- of the uniform light beam of hot spot On 2, each multispectral orthogonal thereto array arrangement assist side 202-1 of Sony ericsson mobile comm ab 202-2；First optical lens array 203 Above have the side of the refractive lenslet of multiple orthogonal thereto array arrangements towards multispectral irradiation mould group 202, the second optical lens The side of refractive lenslet on lens array 204 with multiple orthogonal thereto array arrangements is backwards to multispectral irradiation mould group 202, and the Each lenslet on two optical lens arrays 204 is overlapped and each with the center of each lenslet on the first optical lens array 203 Side corresponds；Multispectral irradiation mould group 202 is 3~5mm, the first optical lens at a distance from the first optical lens array 203 Array 203 is 0.85~1.15 times of the focal length of lenslet at a distance from the second optical lens array 204.
In the present embodiment, the multispectral irradiation mould group in radiation source is used to generate the exposure light of optical dynamic therapy, It is positioned close to the side of irradiator end cap.
Preferably, it is additionally provided at least one radiator fan 205 between multispectral irradiation mould group 202 and rear end cap 201, uses It radiates, is also can effectively avoid because the heat that multispectral irradiation mould group generates generates patient not in multispectral irradiation mould group Suitable sense.
In the multispectral irradiation mould group, on wiring board orthogonal thereto array arrangement at least one can generate different peak value waves The multispectral Sony ericsson mobile comm ab of long parallel collimation and the uniform light beam of hot spot.After being arranged in this way, multiple multispectral solid-state hairs Optical device forms an area source, and each multispectral Sony ericsson mobile comm ab generates the parallel collimation and light of more different peak wavelengths The uniform light pencil of spot, thus entire multispectral irradiation mould group can produce it is identical with the quantity of multispectral Sony ericsson mobile comm ab Respectively independent parallel beamlet, wherein each beamlet is made of more light pencils, and between existing between each beamlet Gap, more beamlets constitute an angle pencil of ray again, so as to provide enough illumination power densities for optical dynamic therapy；Mostly light The angle pencil of ray that spectrum irradiation mould group generates successively passes through the first optical lens array and the output of the second optical lens array, realizes to quilt The Uniform Irradiation of the treatment region of curer.
In practical applications, multispectral irradiation mould group is set as 3~5mm at a distance from the first optical lens array, can expire The needs of sufficient practical application and assembly technology.First optical lens array is lenslet at a distance from the second optical lens array The back focal plane that 0.85~1.15 times of focal length, i.e. the second optical lens array are set in parallel in the first optical lens array is attached Nearby.
Specifically, the lenslet on the first optical lens array and the second optical lens array be regular hexagon or rectangle, The seamless close arrangement of the first optical lens array and the lenslet on the second optical lens array may be implemented.
Specifically, identical as the focal length of lenslet at a distance from the first optical lens array and the second optical lens array, it can So that hot spot even results of the irradiation in the treatment region of patient are best.
First optical lens array and the second optical lens array can be used from visible light to infrared light wave-length coverage all Material processing and fabricating with good light permeability, such as polymethyl methacrylate materials.
In addition, in practical applications, multiple multispectral irradiation mould group close-packed arrays can be formed a plane or cambered surface Optical dynamic therapy light source, keep its effective irradiated area bigger, the first optical lens array of corresponding setting and second Optical lens array is also a plane or an arc surface.If multiple multispectral irradiation mould group close-packed arrays form a cambered surface, the first light The cambered surface that the cambered surface curvature and multiple multispectral irradiation mould group close-packed arrays for learning lens array and the second optical lens array are formed Cambered surface curvature it is identical.
On the basis of the above embodiments, referring to Figure 5, multispectral Sony ericsson mobile comm ab includes package substrate 501, envelope It fills and is provided with reflector 502 on the loading end of substrate 501, at least two different peaks are provided in the accommodation space of reflector 502 It is worth the solid-state light emitting element 503 of wavelength；501 two sides of package substrate are provided at least two pairs of electrodes 504, and electrode 504 and solid-state are sent out The positive and negative anodes of optical element 503 are connected, and electrode 504 is also connect with host；Also closed off at the light-emitting window of reflector 502 be provided with it is micro- Lens array 505, microlens array 505 is parallel with package substrate 501, and has multiple orthogonal thereto arrays on microlens array 505 The side of the refractive hemispherical microlenses of arrangement is backwards to solid-state light emitting element 503.
In the present embodiment, the transparent materials such as epoxy resin or silica gel are not used to anti-in above-mentioned multispectral Sony ericsson mobile comm ab It penetrates cup to be filled, but closing is provided with a microlens array, the ruler of the microlens array at the light-emitting window of reflector The very little size than the light-emitting window of reflector is bigger, so that microlens array can cover all the light-emitting window of reflector, so that Microlens array is fixed at a distance from each solid-state light emitting element and each solid-state light emitting element is isolated with outside air, also makes The structure of entire device is more compact, easy to produce and use.After being arranged in this way, each solid-state light emitting element can be made directly exposed In air, so as to reduce etendue.And refractive index is used to be packaged for the transparent material of n to solid-state light emitting element Mode, etendue can expand n2Times.
Compared with two kinds of encapsulating structures in the prior art, i.e., using plane packaging structure or in the plane packaging structure Light output surface on be further added by a hemispherical lens structure, the lenticule battle array being arranged in above-mentioned multispectral Sony ericsson mobile comm ab Column significantly reduce the thickness of lens, thus greatly reduce energy loss of the light in lens.Therefore, by reflector Light-emitting window at encapsulate the microlens array, not only solve the efficiency of light extraction problem of multispectral Sony ericsson mobile comm ab, but also The Space Angle of each different wave length light can be constrained to it is approximately uniform, formed illumination power density distribution uniformly and position one The large spot of cause can effectively improve the clinical effectiveness of optical dynamic therapy.
Meanwhile the microlens array can collect the light that each solid-state light emitting element is emitted in wide-angle light emitting region Line, and form the parallel light pencil of identical with the quantity of the lenticule on microlens array more collimations.The result handled in this way It is, it is different although set up the spatial position of each solid-state light emitting element on same package substrate, but for lenticule battle array For each lenticule on column, it is on same position that the light of incident different wave length can be seen as by approximation Point light source.Therefore, the light that each solid-state light emitting element issues is after microlens array collimates, each difference in light pencil The Space Angle distributional difference of peak wavelength light is constrained for very little, and the light pencil of each difference peak wavelength is in patient Treatment region is formed by facula position close to identical.Since the lenticule on microlens array is closely arranged, more thin light The hot spot that beam is formed in the treatment region of patient is connected to each other, and forms illumination power density distribution uniformly and position consistency Large spot, the clinical effectiveness of optical dynamic therapy can be effectively improved.
Generally, the light-emitting window of reflector be rectangle or circle, the light-emitting window of the shape and reflector of microlens array Shape matches.In addition, the bottom surface of reflector is preferably consistent with the shape of its light-emitting window, and the height of reflector and micro- The focal length of mirror is identical.
Preferably, solid-state light emitting element includes the red-light LED core in 620~630nm wave-length coverage with peak wavelength Piece has the green LED chip of peak wavelength and in 460~470nm wave-length coverage in 520~530nm wave-length coverage Blue-light LED chip with peak wavelength.
Since the peak value of the extinction spectrum of most photosensitizer is 625nm or 525nm or 465nm, so solid luminescent Element is preferably respectively in above-mentioned wave-length coverage with red LED chip, green LED chip and the blue-ray LED of peak wavelength Chip can satisfy most of optical dynamic therapy to the particular demands of the wavelength of light.
Further, the two sides of package substrate are provided with three pairs of electrodes, three pairs of electrodes respectively with red LED chip, green light LED chip is connected with the positive and negative anodes of blue-light LED chip, and each electrode is also connect with host, thus each LED chip light and Extinguishing can be independently controlled, convenient to control when carrying out optical dynamic therapy each LED chip.
Preferably, according to an embodiment of the invention, the radius of lenticule is 0.05~0.25mm, the focal length of lenticule is 0.8mm, the distance between rounded bottom surface of contiguous microlens are 0mm.
The radius for the microlens array being arranged at the light-emitting window of reflector is 0.05~0.25mm, the circle of contiguous microlens When the distance between center of circle of shape bottom surface is 0.1~0.5mm, it is obvious that efficiency of light extraction promotes effect.At this point, the circle of contiguous microlens The distance between shape bottom surface d=0mm, effective aperture ratio [the π r of microlens array2/(2r+d)2The value of] × 100% is 78.5%.
According to above-mentioned preferred lenticule parameter, the making material of microlens array selects the wave to visible light to infrared light The light of long range all has the optical glass of good light permeability.Therefore, in the radius of above-mentioned lenticule and adjacent micro- In the case that the distance between rounded bottom surface of mirror is 0mm, the focal length of each lenticule on the microlens array that made by the material For 0.8mm.
On the basis of the above embodiments, irradiator further include range sensor and with range sensor connection at a distance from Detection circuit is connect apart from detection circuit with host.
It is also provided with range sensor in the present embodiment, in irradiator and detects electricity at a distance from range sensor connection Road, can be with the distance between real-time detection irradiator and the treatment region of patient.Determining in detection circuit and host Plan control unit connection, so that the Decision Control unit in host can be with the treatment region of real-time detection irradiator and patient The distance between, and user is prompted to adjust the distance between the treatment region of irradiator and patient in time, it is ensured that irradiator It can be irradiated under determining irradiation distance to the treatment region of patient, to obtain preferable therapeutic effect.
Range sensor and digital miniature laser range finder module being used apart from detection circuit, range accuracy can reach ± The distance value of 1.0mm, real-time measurement send host to binary-coded decimal format.The range sensor and structure apart from detection circuit It is all made of usually existing technical solution and realizes that details are not described herein.
On the basis of the structure described in above-mentioned each embodiment, referring to shown in Fig. 6, Fig. 6 provides for the embodiment of the present invention A kind of optical power therapentic equipment in irradiator and irradiator in the prior art radiation response comparison diagram.Wherein, Fig. 6 (a) It is that irradiator described in above-described embodiment projects peak wavelength to the white curtain of distance 50cm under dark room conditions as 625nm Captured picture after feux rouges, Fig. 6 (b) are to form multispectral irradiation light using multispectral Sony ericsson mobile comm ab in the prior art Source mould group, and the irradiator further formed after the first optical lens array and the second optical lens array is removed, same Captured picture after being 625nm feux rouges to the white curtain of distance 50cm projection peak wavelength under dark room conditions.From Fig. 6 (a) With on Fig. 6 (b) it can clearly be seen that both difference, hot spot on white curtain, whether from illumination uniformity or light From the point of view of intensity, Fig. 6 (a) suffers from significant raising than Fig. 6 (b).
On the basis of the structure described in above-mentioned each embodiment, in one possible implementation, referring to shown in Fig. 7, Host 701 and irradiator 702 stop multi-joint suspension arm 703 by resistance automatically and connect, which, which stops multi-joint suspension arm 703, is The linking arm in joint is damped with 6, including sequentially connected upper arm parts 7031, lower arm part 7032, wrist 7033 and end connect Socket part 7034, wherein upper arm parts 7031 by be rigidly fixed in host 701 case top center support portion 704 realize its with The rear end of the mechanical connection of host 701, terminal connection portion 7034 is fixedly connected with the top rigid of irradiator 702.Irradiator 702 It can stop multi-joint suspension arm 703 by the automatic resistance and adjust the distance between itself and the treatment region of patient, irradiate simultaneously Device 702 stops the call wire and the progress of host 701 that D type on multi-joint suspension arm 703 protects in irdome 7035 by being built in automatic resistance It is electrically connected.
In order to realize that not will cause automatic resistance during adjusting 702 spatial attitude of irradiator stops multi-joint suspension arm The distortion of call wire in 703 is distinguished in the lower section of upper arm parts 7031 and lower arm part 7032 that automatic resistance stops multi-joint suspension arm 703 Two D type shield irdomes 7035 are set, and call wire can protect irdome 7035 by the D type of 7031 lower section of lower arm part 7032 and upper arm parts Center passes through.
It is additionally provided with hydraulic damper in the inside of lower arm part 7032, when manually adjusting irradiator 702 and patient When the distance between treatment region, due to the effect of the hydraulic damper and damping joint, irradiator 702 is controlled with patient Treating the distance between region can automatically keep, and lock without other additional locking mechanisms to cantilever joint.Automatic resistance stops more Joint suspension arm 703 can realize that 702 upper-lower height 50cm of irradiator, left-right rotary are turn 90 degrees and up and down within the scope of 90 degree of pitching Adjustment so that patient be facilitated to receive treatment using sitting posture or prone position, while easily realizing irradiator 702 and patient Treatment region between distance adjustment, be in it on position of desired distance.
Further, be provided on the shell of host 701 includes in man-machine interaction unit for treating parameter and state The liquid crystal display 705 of display and the touch screen and IC inputted for treating parameter being arranged on the liquid crystal display 705 The IC card seat 706 of card administrative unit.Universal caster wheel 707 is additionally provided in the bottom of 701 shell of host.Wherein, before being located at shell Two universal caster wheels 707 in portion have braking mechanism, and the movement of whole device is facilitated to fix with position.
On the basis of structure based on optical power therapentic equipment described in above-mentioned each embodiment, the embodiment of the present invention is also mentioned For a kind of photodynamic-therapeutic method, referring to shown in Fig. 8, this method is specifically included that
801, host receives the preset illumination parameter of input and light sequence irradiation mode, illumination parameter include at least one The light energy density and illumination function of the peak wavelength of exposure light and the exposure light to match with the treatment region of patient Rate density；
802, according to illumination parameter, treatment time and irradiation distance are determined, and is answered according to light sequence irradiation mode output phase Light source control signal；
803, light source control signal is sent to irradiator, is arranged so that irradiator meets light according to light source control signal generation Sequence irradiates the parallel collimation and the uniform exposure light of hot spot of at least one different peak wavelengths of mode, and presses under irradiation distance It is irradiated according to treatment time to the treatment region of patient.
In step 801, different patient and its different treatment region are realized in order to targetedly a Property therapeutic scheme, i.e., different patient is according to different irradiation distances, different treatment times and different peak value wave Light sequence irradiation mode of long light etc. is irradiated to obtain preferable therapeutic effect, then is needed through the human-computer interaction in host Default illumination parameter and light the sequence irradiation mode for the patient of unit.
Specifically, illumination parameter includes the peak wavelength of at least one exposure light and the treatment region phase with patient The light energy density and illumination power density of matched exposure light.
Preferably, according to an embodiment of the invention, light sequence irradiation mode includes the first light sequence irradiation mode, the second light The irradiation mode that sorts and third light sequence irradiation mode；
First light sequence irradiation mode is that a kind of exposure light of peak wavelength repeats the treatment region of patient Continuous or segmentation irradiation, until stopping when reaching its preset light energy density；Second light sequence irradiation mode is at least The exposure light of two kinds of different peak wavelengths carries out duplicate continuous or segmentation to the treatment region of patient simultaneously and irradiates, when it A kind of middle exposure light stops irradiation when reaching its preset light energy density, remaining exposure light continues the treatment to patient Region is irradiated, until all exposure lights stop irradiation when reaching its preset light energy density；Third light sequence spoke Duplicate company is carried out to the treatment region of patient according to the exposure light cycle alternation that mode is at least two different peak wavelengths Continuous or segmentation irradiation, stops irradiation when one of exposure light reaches its preset light energy density, remaining exposure light after It is continuous that the treatment region of patient is irradiated, until stopping when all exposure lights reach its preset light energy density Irradiation.
In step 802, the exposure light of preferable therapeutic effect is reached in the treatment region for being determined to make patient After peak wavelength, between the illumination power density and irradiator of the exposure light of the peak wavelength and the treatment region of patient Distance is corresponding.Therefore, the Decision Control unit in host can be according to the peak wavelength and the exposure light of the exposure light Illumination power density, determine irradiation distance, i.e. the distance between the treatment region of irradiator and patient.It in turn, can be with According to the illumination power density of the exposure light and light energy density to be achieved is needed, determines treatment time, i.e., irradiator is to quilt The time that the treatment region of curer is irradiated.
Preferably, in one possible implementation, the step of determining irradiation distance according to illumination parameter can be according to such as Under type is implemented:
S1, the distance-illumination saturation effect database for establishing exposure light, distance-illumination saturation effect data Library is used to indicate exposure light and illumination power density average value of the target target surface under different distance；
S2, it is based on distance-illumination saturation effect database, is irradiated using linear interpolation method according in illumination parameter The illumination power density of light determines irradiation distance.
Due to the exposure light of different peak wavelengths illumination power density and irradiator and patient treatment region it Between distance be corresponding.Decision Control unit in host is previously stored with distance-illumination saturation effect database, The relational database is according under the different irradiation distances between irradiator and target target surface, and the exposure light of different peak wavelengths exists The corresponding relationship of illumination power density average value in the uniform light spots region of target target surface and establish, i.e., a kind of peak wavelength Exposure light different illumination power densities is respectively corresponded under different irradiation distances.
Illumination power density refers to the gross energy in unit illuminating area, receiving illumination on the unit time, unit mW/ cm2.Illumination power density is the basic parameter of PDT dosimeter, it determines that illumination locally receives photon intensity, is presently believed to be Determine the key factor of PDT curative effect.The illumination power density that the optical power therapentic equipment of the prior art provides typically refers to light source The illumination power density of Exit positions, in practical applications, due to the difference of distance between light source and irradiated site, arrival is controlled The illumination power density of the treatment region for the treatment of person be it is uncertain, especially by change light source drive current size realize illumination The optical power therapentic equipment of power density adjustment, inherently changes in the illumination power density of light source Exit positions.Although Optical sensor is arranged in the treatment region of patient for some optical power therapentic equipments or CCD carries out illumination power density and examines in real time It surveys, then adjusting distance between light source and irradiation area by modes such as automatic or manuals makes the illumination power density for the treatment of region Measured value is in range of set value, although this scheme realizes the accurate of the therapentic part illumination power density of patient Control, but since the irradiation light that set optical sensor or CCD generate part to therapentic part is blocked, to influence treatment region The optical dynamic therapy effect in domain, and the program also will increase the complexity of device and the triviality of use process.
In the present embodiment by way of establishing distance-illumination saturation effect database, can accurately it use Linear interpolation method determines corresponding irradiation distance according to the corresponding illumination power density of the exposure light, so that irradiator can be It is irradiated under determining irradiation distance to the treatment region of patient, to obtain preferable therapeutic effect.
Specifically, the specific establishment process of distance-illumination saturation effect database can refer to following process and carry out:
First it is defined as follows parameter:
The uniformity: Ai=Ei/Ep (1)
Coefficient of uniformity: E=Se/S (2)
In formula, Ei is the illumination power density that light irradiates target target surface glazing spot certain point；Ep is that light irradiates target Illumination power density peak value on target surface in hot spot；S is the gross area that light irradiates target target surface glazing spot；Se is light irradiation The area in the region Ai >=0.85 in target target surface glazing spot；The region of Ai >=0.85 is defined as uniform light spots region.
One target target surface is set in the irradiation position light-emitting face 100mm apart from irradiator, is thrown respectively to target target surface It penetrates the feux rouges within the scope of wavelength 620-630nm with peak wavelength, there is peak wavelength within the scope of wavelength 520-530nm Green light and the blue light within the scope of wavelength 460-470nm with peak wavelength, measure each peak wavelength using light irradiatometer Illumination power density of the exposure light in target target surface glazing spot.
Specifically, target target surface is divided into 10 × 10mm square measurement subregion, measurement target is each sub-regions The illumination power density values for measuring target are denoted as Ei by geometric center point, and the uniformity Ai of measurement target is calculated according to formula (1). Illumination power density values Ei in the region Ai >=0.85 is carried out to take its average value after adding up, which is demarcated as corresponding peak value wave The illumination power density values on long exposure light irradiated site surface in distance 100mm.Using 20mm as distance increment, change irradiation The irradiation light-emitting face of device repeats the above process at a distance from target target surface, until distance value is 300mm, completes calibration test. By the above process, the distance between irradiator and target target surface are established from 100mm to 300mm, and is changed by 20mm increment Distance-illumination saturation effect database.
Since the Sony ericsson mobile comm ab used in irradiator has the advantages that long service life, light intensity attenuation are small, on Stating more can chronically be stored in determining in host by distance-illumination saturation effect database that calibration measurement is established In plan control unit, the treatment region difference peak wavelength exposure light for completing patient indirectly by the measurement adjusted the distance is realized Illumination power density average value Accurate Determining.In addition, can increase simultaneously when carrying out periodic inspection to above-mentioned distance- Illumination saturation effect database is carried out re-scaling measurement and be updated, to guarantee that illumination power density average value is surveyed indirectly Fixed accuracy, the database after re-scaling measurement pass through the communication unit in host and establish the intelligent terminal or clothes of connection Business device is updated.
After the treatment time and irradiation distance that patient has been determined, the Decision Control unit in host sorts according to light Irradiation mode exports corresponding light source control signal, and light source control signal is transferred into light source driving units, to being connected thereto Irradiator in each LED light source independent constant-current source circuit electric current implement on-off control, to realize different peak value waves The open and close of long exposure light.
In three kinds of light sequence irradiation mode that light sequence irradiation mode includes, comprising duplicate continuous or be segmented both Radiation mode.Under identical illumination power density, the treatment region of patient obtains same light energy density, segmentation Radiation mode needs more treatment times than continuous irradiation mode.But in segmentation radiation mode, due to target site The oxygen concentration of tissue and peripheral vessels is higher, and exposure light irradiation can generate more fully singlet oxygen, to obtain better Photodynamic effect, in addition, segmentation radiation mode, which can reduce the heat generated due to light source, gives patient bring discomfort.Cause This, in practical application, generalling use segmentation radiation mode in three kinds of light sequence irradiation modes to be treated.
Referring to shown in Fig. 9, Fig. 9 is in a kind of photodynamic-therapeutic method provided in an embodiment of the present invention in the first light sequence spoke According to peak wavelength a kind of under mode exposure light be segmented under radiation mode lighting with extinguish control signal schematic representation.Figure In, ToffFor dark cycle time, exposure light is in OFF state during this period；TonFor bright cycle time, during this period at exposure light Illuminating state under pulsewidth modulation；F is the frequency that pulsewidth modulation is carried out to exposure light；tonWhen being irradiated for the light of pulsewidth modulation Between；tcReach the treatment region of patient to control required for preset light energy density for the exposure light of the peak wavelength Treat the time.
Wherein, the treatment region of patient reaches treatment time t required for preset light energy densityc(unit: Second), i.e. the first light sequence irradiation mode under required treatment time be calculated as follows:
tc=H0/[(E0×D1×D2)×1000] (3)
Wherein, E0For a kind of illumination power density of the exposure light of peak wavelength, unit mW/cm2；H0For a kind of peak value The light energy density of the exposure light of wavelength, unit J/cm2；D1The irradiation duty ratio of exposure light, D when for pulsewidth modulation1=ton ×f；D2For bright cycle time duty ratio, D2=Ton/(Ton+Toff)。
In bright cycle time TonPeriod, the irradiation of exposure light are based on photodynamic reaction process machine using non-inverting output What reason considered.Since excitation state will be transitted to after absorbing the light energy more than threshold value in ground state photosensitizer molecule, it is in The photosensitizer molecule of excitation state first transits to triplet state, and then decay returns to ground state.Photosensitizer molecule and oxygen in triplet state Molecule occurs redox reaction and releases energy, and forms toxicant singlet oxygen1O2, singlet oxygen destroy pathological tissues or Surrounding blood vessel is to kill pathological tissues.Therefore, corresponding with above-mentioned photodynamic reaction process is irradiation light in tonPeriod The light energy t of generationon×E0The light energy of threshold value needed for photosensitizer molecule need to be met and exceeded from ground state transition to excitation state, And in 1/f-tonPeriod stops light irradiation, and the photosensitizer molecule of excitation state releases energy, and forms toxicant singlet oxygen and declines Ground state is changed back to, is so recycled.In embodiments of the present invention, it is preferable that the frequency f for carrying out pulsewidth modulation to exposure light is fixed as 1.75KHz；The light irradiation time t of pulsewidth modulationonValue range are as follows: 1/2f≤ton≤1/f.Specifically, host can be passed through In man-machine interaction unit to tonIt is set, sets step pitch 50usec.
Singlet oxygen during photodynamic reaction1O2Production will to consume oxygen in target site tissue and peripheral vessels dense Degree, excessive oxygen concentration consumption will reduce singlet oxygen1O2Yield cannot continue so as to cause optical dynamic therapy effect, therefore, In the light source control signal lighted and extinguished arranges, each bright cycle time TonFollowed by primary dark cycle time Toff, with It realizes and segmentation irradiation is implemented to the treatment region of patient.Utilize dark cycle time Toff, target site tissue and peripheral vessels Effectively restore oxygen concentration from body processes system, form sufficient singlet oxygen when enabling to irradiate next time, to reach more Good therapeutic effect.In embodiments of the present invention, it is preferable that bright cycle time TonRange be 1.0~10.0sec；The dark period Time ToffRange be 1.0~10.0sec.It specifically, can be by the man-machine interaction unit in host to TonAnd ToffIt carries out Setting sets step pitch 0.1sec.
In the segmentation irradiation process in above-mentioned first light sequence irradiation mode, if by dark cycle time ToffIt is set as Zero, and by the light irradiation time t of the pulsewidth modulation in the bright periodonBe set as 1/f, then can treatment region to patient it is real Apply continuous irradiation.
Since many photosensitizers have multiple characteristic absorption peaks on its extinction spectrum, such as the widely used δ-in clinic Aminolevulinic acid (5-ALA), substantially δ-aminolevulinic acid do not have light sensitive characteristic, it is by enzymatic reaction synthesized human Endogenous photosensitizers protoporphyrin PpIX substance and play photosensitization.The extinction spectrum figure of protoporphyrin PpIX is in wavelength 410nm, wave Long 510nm, wavelength 545nm, wavelength 580nm and wavelength 630nm all have absorption peak.In optical dynamic therapy, selection and original The exposure light of multiple peak wavelengths similar in multiple absorption peaks of porphyrin PpIX extinction spectrum figure carries out joint radiation treatment, energy Therapeutic effect more better than a kind of above-mentioned exposure light of peak wavelength is obtained, and required treatment time shortens.Therefore, upper On the basis of stating the first light sequence irradiation mode, and it is provided with the second light sequence irradiation mode and third light sequence irradiation mode, It is that the exposure light at least two different peak wavelengths repeats the treatment region of patient in both modes It is continuous or segmentation irradiation.
Referring to Fig.1 shown in 0, Figure 10 is to sort in a kind of photodynamic-therapeutic method provided in an embodiment of the present invention in the second light The exposure light of at least two peak wavelengths is in the control signal hint lighted with extinguished being segmented under radiation mode under irradiation mode Figure.In figure, tc1The treatment region of patient is set to reach preset light energy density for the exposure light of the first peak wavelength Required treatment time, tc2The treatment region of patient is set to reach preset illumination for the exposure light of second of peak wavelength Treatment time required for energy density, tc3The treatment region of patient is set to reach pre- for the exposure light of the third peak wavelength If light energy density required for treatment time, tcFor required treatment time under the second light sequence irradiation mode.
Wherein, the exposure light of the first peak wavelength makes the treatment region of patient reach preset light energy density Required treatment time tc1(unit: second), the exposure light of second of peak wavelength make the treatment region of patient reach pre- If light energy density required for treatment time tc2(unit: second), the exposure light of the third peak wavelength make patient Treatment region reach treatment time t required for preset light energy densityc3The sequence irradiation of (unit: second) and the second light Required treatment time t under modec(unit: second) is calculated as follows:
tc1=H10/[(E10×D1×D2)×1000] (4)
tc2=H20/[(E20×D1×D2)×1000] (5)
tc3=H30/[(E30×D1×D2)×1000] (6)
tc=Max (tc1, tc2, tc3) (7)
Wherein, E10、E20And E30The respectively exposure light of the first peak wavelength, second of peak wavelength exposure light and The illumination power density of the exposure light of three kinds of peak wavelengths, unit mW/cm2；H10、H20And H30Respectively the first peak value wave The light energy density of the exposure light of long exposure light, second of peak wavelength exposure light and the third peak wavelength, unit are J/cm2。
After starting to carry out the optical dynamic therapy under the second light sequence irradiation mode, the Decision Control unit in host is not to Light energy density value with the exposure light of peak wavelength is accumulated, when the illumination energy of the exposure light of one of peak wavelength When metric density value accumulated value reaches its preset value, Decision Control unit stops putting out for the exposure light of the time corresponding peak wavelength The light source control signal to go out, and so on, until accumulated time reaches tcValue.
It should be noted that in the case where the second light shown in Fig. 10 sorts irradiation mode the exposure light of different peak wavelengths point In the bright light source control signal with extinguishing, in bright cycle time, exposure light is to carry out non-inverting output with fixed frequency f.
Referring to Fig.1 shown in 1, Figure 11 is to sort in a kind of photodynamic-therapeutic method provided in an embodiment of the present invention in third light The exposure light of at least two peak wavelengths is in the control signal hint lighted with extinguished being segmented under radiation mode under irradiation mode Figure.In figure, tc1The treatment region of patient is set to reach preset light energy density for the exposure light of the first peak wavelength Required treatment time, tc2The treatment region of patient is set to reach preset illumination for the exposure light of second of peak wavelength Treatment time required for energy density, tc3The treatment region of patient is set to reach pre- for the exposure light of the third peak wavelength If light energy density required for treatment time, tcFor required treatment time under third light sequence irradiation mode.
Wherein, the exposure light of the first peak wavelength makes the treatment region of patient reach preset light energy density Required treatment time tc1(unit: second), the exposure light of second of peak wavelength make the treatment region of patient reach pre- If light energy density required for treatment time tc2(unit: second), the exposure light of the third peak wavelength make patient Treatment region reach treatment time t required for preset light energy densityc3The sequence irradiation of (unit: second) and third light Required treatment time t under modec(unit: second) is calculated as follows:
tc1=H10/[(E10×D1×D2)×1000] (8)
tc2=H20/[(E20×D1×D2)×1000] (9)
tc3=H30/[(E30×D1×D2)×1000] (10)
tc=tc1+tc2+tc3 (11)
Wherein, E10、E20And E30The respectively exposure light of the first peak wavelength, second of peak wavelength exposure light and The illumination power density of the exposure light of three kinds of peak wavelengths, unit mW/cm2；H10、H20And H30Respectively the first peak value wave The light energy density of the exposure light of long exposure light, second of peak wavelength exposure light and the third peak wavelength, unit are J/cm2。
After starting to carry out the optical dynamic therapy under third light sequence irradiation mode, the Decision Control unit in host is not to Light energy density value with the exposure light of peak wavelength is accumulated, when the illumination energy of the exposure light of one of peak wavelength When metric density value accumulated value reaches its preset value, the exposure light that Decision Control unit stops the time corresponding peak wavelength is extinguished Light source control signal, and so on, until accumulated time reaches tcValue.
It should be noted that the sort different peak wavelength exposure lights under irradiation mode of third light in Figure 11 are lighted and are put out In the light source control signal to go out, in bright cycle time, exposure light is to carry out non-inverting output with fixed frequency f.
In step 803, host exports corresponding light source control signal according to above-mentioned light sequence irradiation mode, and sends Into irradiator.Irradiator generates the different peak value waves of at least one for meeting light sequence irradiation mode according to the light source control signal Long parallel collimation and the uniform exposure light of hot spot, and by adjusting the distance between irradiator and the treatment region of patient It is in the above-mentioned irradiation distance obtained, is finally shone according to the above-mentioned treatment time obtained to the treatment region of patient It penetrates.
It, can it is preferable to use this hairs according to the disease of the photosensitizer and treatment that optical dynamic therapy uses in optical dynamic therapy Appointing in the sequence of the first light described in bright embodiment irradiation mode, the second light sequence irradiation mode or third light sequence irradiation mode One mode.Specifically, if the photosensitizer used only one characteristic absorption peak on extinction spectrum figure, although also There are other absorption peaks, but its peak value very little when compared with characteristic absorption peak, it is clear that the light power described in the embodiment of the present invention is controlled Selection and a kind of exposure light of peak wavelength similar in photosensitizer characteristic absorption peak on the basis for the treatment of device, and arranged according to the first light It is the most appropriate that sequence irradiation mode, which carries out optical dynamic therapy,.
And to endogenous photosensitizers protoporphyrin PpIX etc., according to the second sequence irradiation mode or third light sequence irradiation mode Optical dynamic therapy is carried out, better therapeutic effect can be obtained.According to the optical characteristics of tissue, due to organizing the scattering to exposure light Rate and absorptivity have differences, and the penetrating power of the exposure light of different peak wavelengths in the tissue is different, and the wavelength of exposure light is got over Small penetration depth within the organization is more shallow.It sorts under irradiation mode in the second light, the exposure light of each peak wavelength is in the bright period It is to be irradiated in the treatment region of patient simultaneously in time, generates singlet oxygen in photosensitizer molecule redox reaction While will consume the oxygen concentration of skin shallow-layer and deep tissues, since the capillary of shallow layer tissue is distributed opposite deep tissues Want sparse, the speed of shallow layer tissue's recovery oxygen concentration is slower than deep tissues within same dark cycle time, therefore is easy to make At shallow layer tissue's anoxic.Therefore, sort irradiation model comparision with third light, and the second light sorts irradiation mode more suitable for such as daylight The lesions such as keratosis, bowen's disease are stored in the skin disease of organism internal ratio deep place.It sorts under irradiation mode in third light, respectively The exposure light of a peak wavelength is different peak value waves in the treatment region for being alternately irradiated to patient within bright cycle time Long exposure light has longer dark cycle time, and shallow layer tissue has time enough to restore its oxygen concentration in organism, therefore, It sorts with the second light and irradiates model comparision, third light sequence irradiation mode is stored in organism more suitable for lesions such as such as acne vulgaris The disease of inner skin surface location.
It should be noted that for simple description, therefore, it is stated as a series of for the embodiment of the above method Combination of actions, but those skilled in the art should understand that, the present invention is not limited by the sequence of acts described.Secondly, Those skilled in the art should also know that the embodiments described in the specification are all preferred embodiments, related movement It is not necessarily essential to the invention.
It should be noted that light power described in photodynamic-therapeutic method provided in an embodiment of the present invention and previous embodiment Therapeutic device belongs to identical technical concept, and unmentioned content can refer in aforementioned device embodiment in embodiment of the method Illustrate, details are not described herein.
In the above embodiment of the invention, it all emphasizes particularly on different fields to the description of each embodiment, does not have in some embodiment The part of detailed description, reference can be made to the related descriptions of other embodiments.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of optical power therapentic equipment, which is characterized in that described device includes:
Host for determining treatment time and irradiation distance according to preset illumination parameter, and sorts according to preset light and irradiates Mode exports corresponding light source control signal；
Irradiator is connect with the host, and for receiving the light source control signal, generation meets the light sequence irradiation mould The parallel collimation and the uniform exposure light of hot spot of at least one different peak wavelengths of formula, and according to institute under the irradiation distance State treatment time is irradiated to the treatment region of patient.
2. the apparatus according to claim 1, which is characterized in that the irradiator includes irradiator end cap and is arranged in institute State the radiation source below irradiator end cap；
The radiation source includes successively multispectral irradiation mould group, the first optical lens array and the second optical lens disposed in parallel Lens array；The multispectral irradiation mould group includes wiring board and at least one can generate the parallel collimation of different peak wavelengths And the multispectral Sony ericsson mobile comm ab of the uniform light beam of hot spot, each multispectral orthogonal thereto array arrangement of Sony ericsson mobile comm ab exist On the wiring board；The side of refractive lenslet on first optical lens array with multiple orthogonal thereto array arrangements Towards the multispectral irradiation mould group, the refractive on second optical lens array with multiple orthogonal thereto array arrangements is small Each lenslet of the side of lens in the multispectral irradiation mould group, second optical lens array and first light The center for learning each lenslet on lens array is overlapped and each side corresponds；The multispectral irradiation mould group and first light The distance for learning lens array is 3~5mm, and first optical lens array is institute at a distance from second optical lens array 0.85~1.15 times for stating the focal length of lenslet.
3. the apparatus of claim 2, which is characterized in that the multispectral Sony ericsson mobile comm ab includes package substrate, It is provided with reflector on the loading end of the package substrate, at least two different peaks are provided in the accommodation space of the reflector It is worth the solid-state light emitting element of wavelength；The package substrate two sides are provided at least two pairs of electrodes, and the electrode and the solid-state are sent out The positive and negative anodes of optical element are connected, and the electrode is also connect with the host；It also closes off and is provided at the light-emitting window of the reflector Microlens array, the microlens array is parallel with the package substrate, and has on the microlens array multiple orthogonal thereto The side of the refractive hemispherical microlenses of array arrangement is backwards to the solid-state light emitting element.
4. device according to claim 3, which is characterized in that the radius of the lenticule is 0.05~0.25mm, described The focal length of lenticule is 0.8mm, and the distance between rounded bottom surface of the adjacent lenticule is 0mm.
5. the apparatus according to claim 1, which is characterized in that the irradiator further include range sensor and with it is described Range sensor connection apart from detection circuit, it is described to be connect apart from detection circuit with the host.
6. device described according to claim 1~any one of 5, which is characterized in that the host includes human-computer interaction list Member, Decision Control unit and light source driving units, the man-machine interaction unit and the light source driving units are determined with described respectively The connection of plan control unit, the light source driving units are also connect with the irradiator；Wherein, the man-machine interaction unit is for defeated Enter the illumination parameter and light sequence irradiation mode, the Decision Control unit is used to determine institute according to the illumination parameter Treatment time and the irradiation distance are stated, and makes the light source driving units to the irradiation according to light sequence irradiation mode Device exports corresponding light source control signal.
7. device according to claim 6, which is characterized in that the host further includes IC card administrative unit and communication unit Member, the IC card administrative unit and the communication unit are connect with the Decision Control unit respectively；Wherein, the IC card pipe Unit is managed for the illumination parameter of record patient when treating for the first time and light sequence irradiation mode, the communication unit is used for It establishes and communicates to connect with external intelligent terminal or server.
8. a kind of photodynamic-therapeutic method, which is characterized in that the described method includes:
Host receives the preset illumination parameter and light sequence irradiation mode of input, and the illumination parameter includes at least one irradiation The light energy density and illumination function of the peak wavelength of light and the exposure light to match with the treatment region of patient Rate density；
According to the illumination parameter, treatment time and irradiation distance are determined, and answer according to light sequence irradiation mode output phase Light source control signal；
The light source control signal is sent to irradiator, so that the irradiator generates satisfaction according to the light source control signal The parallel collimation and the uniform exposure light of hot spot of at least one different peak wavelengths of the light sequence irradiation mode, and described It is irradiated according to the treatment time to the treatment region of patient under irradiation distance.
9. according to the method described in claim 8, it is characterized in that, light sequence irradiation mode includes the sequence irradiation of the first light Mode, the second light sequence irradiation mode and third light sequence irradiation mode；
The first light sequence irradiation mode is that a kind of exposure light of peak wavelength repeats the treatment region of patient Continuous or segmentation irradiation, until stopping when reaching its preset light energy density；
The second light sequence irradiation mode is the exposure light treatment to patient simultaneously of at least two different peak wavelengths Region carries out duplicate continuous or segmentation irradiation, stops shining when one of exposure light reaches its preset light energy density It penetrates, remaining exposure light continues to be irradiated the treatment region of patient, until all exposure lights reach its preset light Stop irradiation when according to energy density；
The third light sequence irradiation mode is the exposure light cycle alternation of at least two different peak wavelengths to patient Treatment region carries out duplicate continuous or segmentation irradiation, stops when one of exposure light reaches its preset light energy density It only irradiates, remaining exposure light continues to be irradiated the treatment region of patient, presets until all exposure lights reach it Light energy density when stop irradiation.
10. according to the method described in claim 8, it is characterized in that, the step of determining irradiation distance according to the illumination parameter Include:
Establish distance-illumination saturation effect database of the exposure light, the distance-illumination saturation effect data Library is used to indicate the exposure light and illumination power density average value of the target target surface under different distance；
Based on the distance-illumination saturation effect database, using linear interpolation method according to institute in the illumination parameter The illumination power density for stating exposure light determines the irradiation distance.
CN201811566823.5A 2018-12-20 2018-12-20 A kind of optical power therapentic equipment and treatment method Pending CN109675201A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811566823.5A CN109675201A (en) 2018-12-20 2018-12-20 A kind of optical power therapentic equipment and treatment method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811566823.5A CN109675201A (en) 2018-12-20 2018-12-20 A kind of optical power therapentic equipment and treatment method

Publications (1)

Publication Number Publication Date
CN109675201A true CN109675201A (en) 2019-04-26

Family

ID=66188450

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201811566823.5A Pending CN109675201A (en) 2018-12-20 2018-12-20 A kind of optical power therapentic equipment and treatment method

Country Status (1)

Country Link
CN (1) CN109675201A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021151518A1 (en) * 2020-01-31 2021-08-05 Bredent Medical Gmbh & Co. Kg Therapy device for irradiating a surface of tissue

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030216795A1 (en) * 1999-07-07 2003-11-20 Yoram Harth Apparatus and method for high energy photodynamic therapy of acne vulgaris, seborrhea and other skin disorders
CN102488974A (en) * 2011-12-15 2012-06-13 广州市美锐美容健康设备实业有限公司 Pure oxygen- photodynamic composite skin therapeutic instrument
CN202598379U (en) * 2012-03-28 2012-12-12 欧司朗股份有限公司 Lens and illuminating device provided with the same
CN103656868A (en) * 2013-12-12 2014-03-26 中国科学院苏州生物医学工程技术研究所 Neonatal jaundice therapeutic equipment optical device based on LED light source
CN105588043A (en) * 2016-02-23 2016-05-18 天津工业大学 Complex compound eye lens type neonatal jaundice phototherapy illuminating system
CN106999722A (en) * 2014-11-19 2017-08-01 夏普株式会社 Photodynamic therapy device
CN107929950A (en) * 2017-11-08 2018-04-20 中国科学院苏州生物医学工程技术研究所 The multi-modal physical therapeutic system of intelligent three-dimensionalization and its control method

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030216795A1 (en) * 1999-07-07 2003-11-20 Yoram Harth Apparatus and method for high energy photodynamic therapy of acne vulgaris, seborrhea and other skin disorders
CN102488974A (en) * 2011-12-15 2012-06-13 广州市美锐美容健康设备实业有限公司 Pure oxygen- photodynamic composite skin therapeutic instrument
CN202598379U (en) * 2012-03-28 2012-12-12 欧司朗股份有限公司 Lens and illuminating device provided with the same
CN103656868A (en) * 2013-12-12 2014-03-26 中国科学院苏州生物医学工程技术研究所 Neonatal jaundice therapeutic equipment optical device based on LED light source
CN106999722A (en) * 2014-11-19 2017-08-01 夏普株式会社 Photodynamic therapy device
CN105588043A (en) * 2016-02-23 2016-05-18 天津工业大学 Complex compound eye lens type neonatal jaundice phototherapy illuminating system
CN107929950A (en) * 2017-11-08 2018-04-20 中国科学院苏州生物医学工程技术研究所 The multi-modal physical therapeutic system of intelligent three-dimensionalization and its control method

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PARAS N. PRASAD: "《生物光子学导论》", 31 October 2006 *
李勤，吴溯帆: "《激光整形美容外科学》", 31 January 2013 *
王康孙: "《眼科激光基础与临床》", 30 April 2008 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021151518A1 (en) * 2020-01-31 2021-08-05 Bredent Medical Gmbh & Co. Kg Therapy device for irradiating a surface of tissue

Similar Documents

Publication Publication Date Title
US9889314B2 (en) Color light therapy device
JP5378204B2 (en) Light emitting device used for therapeutic treatment and / or cosmetic treatment
US20100100160A1 (en) Methods and devices for self adjusting phototherapeutic intervention
AU2012256023A1 (en) Phototherapy system
CN1079673A (en) The High Power LED that is used for photodynamic therapy
JP6516219B2 (en) Photodynamic therapy light irradiator
CN106581867A (en) Intelligent adjusted LED photodynamic therapeutic apparatus
CN109646808A (en) A kind of smooth power and pure oxygen combination therapy device and treatment method
CN106073718B (en) The fluorescence camera and fluorescent quantitation method of the PpIX concentration distribution of quantitative detection 5-ALA induction
CN109675202A (en) A kind of smooth power and ultrasonic atomizatio combination therapy device and treatment method
CN109675201A (en) A kind of optical power therapentic equipment and treatment method
CN106902468B (en) Rectal suppository LED light source for rectal cancer photodynamic therapy
KR101937789B1 (en) Therapy lighting apparatus
CN201015678Y (en) Light therapeutic apparatus
CN206745754U (en) OLED Icterus treatment boxes
CN106237540A (en) OLED oral cavity therapeutic equipment
CN109621216A (en) Icterus neonatorum light therapy device
CN108310674B (en) A kind of light source for optical dynamic therapy
CN102000393A (en) LED (light-emitting diode)-based portable treatment device transmitting 670nm red light
CN206026881U (en) Light wave treatment device and light wave treatment module
JP2009509698A (en) Ion transfer device
US20150297915A1 (en) Apparatus for maintaining treatment of peripheral neuropathy
CN211132742U (en) Red and blue light therapeutic head mechanism and red and blue light therapeutic instrument
CN201058022Y (en) Light dynamical therapentic equipment with fluorescence diagnostic function
CN106310537A (en) Photodynamic skin therapy and beauty treatment equipment

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20190426

RJ01 Rejection of invention patent application after publication