CN109662186A - A kind of auxiliary reducing blood lipid pressed candy and preparation method thereof - Google Patents
A kind of auxiliary reducing blood lipid pressed candy and preparation method thereof Download PDFInfo
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- CN109662186A CN109662186A CN201910102496.6A CN201910102496A CN109662186A CN 109662186 A CN109662186 A CN 109662186A CN 201910102496 A CN201910102496 A CN 201910102496A CN 109662186 A CN109662186 A CN 109662186A
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- pressed candy
- reducing blood
- blood lipid
- extract
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- 150000002632 lipids Chemical class 0.000 title claims abstract description 34
- 235000009508 confectionery Nutrition 0.000 title claims abstract description 33
- 210000004369 blood Anatomy 0.000 title claims abstract description 30
- 239000008280 blood Substances 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title abstract description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 30
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 claims abstract description 28
- 239000000843 powder Substances 0.000 claims abstract description 25
- 239000011248 coating agent Substances 0.000 claims abstract description 15
- 238000000576 coating method Methods 0.000 claims abstract description 15
- 238000000605 extraction Methods 0.000 claims abstract description 15
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 15
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 13
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 13
- GUBGYTABKSRVRQ-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical compound OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O GUBGYTABKSRVRQ-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 12
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 12
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 12
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- 239000007888 film coating Substances 0.000 claims abstract description 9
- 238000009501 film coating Methods 0.000 claims abstract description 9
- 238000001035 drying Methods 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 85
- 235000019441 ethanol Nutrition 0.000 claims description 40
- 241000220259 Raphanus Species 0.000 claims description 27
- 239000000284 extract Substances 0.000 claims description 25
- 239000000706 filtrate Substances 0.000 claims description 20
- 238000001914 filtration Methods 0.000 claims description 20
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 241001072909 Salvia Species 0.000 claims description 12
- 235000017276 Salvia Nutrition 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 12
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- 239000000047 product Substances 0.000 claims description 8
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- 244000131316 Panax pseudoginseng Species 0.000 claims description 6
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- 238000013461 design Methods 0.000 claims description 5
- 239000000469 ethanolic extract Substances 0.000 claims description 5
- 239000010419 fine particle Substances 0.000 claims description 5
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- 238000010438 heat treatment Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 238000011068 loading method Methods 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
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- 235000013399 edible fruits Nutrition 0.000 claims 1
- 235000013305 food Nutrition 0.000 abstract description 9
- 230000036541 health Effects 0.000 abstract description 8
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract description 7
- 208000008589 Obesity Diseases 0.000 abstract description 3
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- 239000002994 raw material Substances 0.000 abstract description 3
- 235000013376 functional food Nutrition 0.000 abstract description 2
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- 238000005469 granulation Methods 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 19
- 241000700159 Rattus Species 0.000 description 15
- 238000012360 testing method Methods 0.000 description 14
- 201000005577 familial hyperlipidemia Diseases 0.000 description 9
- 235000020188 drinking water Nutrition 0.000 description 8
- 239000003651 drinking water Substances 0.000 description 8
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 8
- 230000002265 prevention Effects 0.000 description 7
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- 150000003626 triacylglycerols Chemical class 0.000 description 4
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- 206010015719 Exsanguination Diseases 0.000 description 1
- 108010023302 HDL Cholesterol Proteins 0.000 description 1
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- 206010036790 Productive cough Diseases 0.000 description 1
- KNAHARQHSZJURB-UHFFFAOYSA-N Propylthiouracile Chemical compound CCCC1=CC(=O)NC(=S)N1 KNAHARQHSZJURB-UHFFFAOYSA-N 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 240000003186 Stachytarpheta cayennensis Species 0.000 description 1
- 235000009233 Stachytarpheta cayennensis Nutrition 0.000 description 1
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- 206010049418 Sudden Cardiac Death Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 239000010703 silicon Substances 0.000 description 1
- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 description 1
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- 230000001225 therapeutic effect Effects 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention belongs to technical field of functional food, more particularly to a kind of auxiliary reducing blood lipid pressed candy and preparation method thereof, reducing blood lipid pressed candy is assisted to specifically include the component of following parts by weight: 1.5-12 parts of radish seed, 3-15 parts of Radix Salviae Miltiorrhizae, 3-12 parts of hawthorn, 1-9 parts of Radix Notoginseng, 1.5-6 parts of silicified microcrystalline cellulose, 0.02-0.15 parts of magnesium stearate, 0.1-0.6 parts of film coating powder；Preparation process mainly includes raw material extraction, concentration, drying, crushing, sieving, granulation, whole grain, tabletting, coating.The pressed candy is easy to carry, suitable for people of all ages, is particularly suitable for hyperlipidemia, obesity and the crowd for having the health demands such as weight-reducing, is the candy categories of food of a health.
Description
Technical field
The invention belongs to technical field of functional food, and in particular to a kind of auxiliary reducing blood lipid pressed candy and its preparation side
Method.
Background technique
Hyperlipemia is a kind of systemic disease, refers to that blood cholesterol (TC) and/or triglycerides (TG) are excessively high or highly dense
Degree lipoprotein cholesterol (HDL-C) is too low, and modern medicine is referred to as dyslipidemia.Damage of the disease to body be concealment, gradually,
Progressive and systemic.Its direct damage is to accelerate systemic atherosclerosis, because the vitals of whole body will be according to
By artery blood supply, oxygen supply, once artery is blocked by atheromatous plaque, serious consequence will lead to.Renal function caused by artery sclerosis
Failure etc., it is all closely related with hyperlipemia.Numerous studies data shows hyperlipemia or cerebral apoplexy, coronary heart disease, cardiac muscle stalk
Extremely, cardiac sudden death is independent and important risk factor.
The Chinese residents nutrition and health survey carried out in China according to the Ministry of Public Health in recent years shows, 18 years old with
Upper resident's total prevalence rate is 18.6%, and for national subject population up to 1.6 hundred million, hyperlipemia has become phagocytosis human health life
The first stealthy killer.
Nowadays China's health products trade has become global healthcare product big country by the development of many years, herein the whole people big health
There is the health food of auxiliary lipid-lowering function to have a vast market space for exploitation under environment.
It is a easy to carry it is an object of the invention to develop, it is suitable for people of all ages, it is particularly suitable for hyperlipidemia, obesity and has
The healthy pressed candy of the crowds of health demands such as weight-reducing.
Summary of the invention
The purpose of the present invention is to provide a kind of auxiliary reducing blood lipid pressed candies, and the pressed candy is with radish seed, Radix Salviae Miltiorrhizae, mountain
Short, bristly hair or beard, Radix Notoginseng are primary raw material, are aided with adhesive, lubricant etc., through raw material extraction, concentration, dry, crushing, sieving, are pelletized, whole
Grain, tabletting, coating and etc. be made, which contains multiple efficacies ingredient, easy to carry, suitable for people of all ages, especially
Suitable for hyperlipidemia, obesity and the crowd for having the health demands such as weight-reducing.
A kind of auxiliary reducing blood lipid pressed candy provided by the invention, it is characterised in that: the auxiliary reducing blood lipid pressed candy
Specifically include the component of following parts by weight: 1.5-12 parts of radish seed, 3-15 parts of Radix Salviae Miltiorrhizae, 3-12 parts of hawthorn, 1-9 parts of Radix Notoginseng, silication
1.5-6 parts of microcrystalline cellulose, 0.02-0.15 parts of magnesium stearate, 0.1-0.6 parts of film coating powder.
Preferably, the auxiliary reducing blood lipid pressed candy specifically includes the component of following parts by weight: 4-10 parts of radish seed
Part, 3-9 parts of Radix Salviae Miltiorrhizae, 6-9 parts of hawthorn, Radix Notoginseng 2-6,2-5 parts of silicified microcrystalline cellulose, 0.05-0.1 parts of magnesium stearate, film packet
0.15-0.45 parts of clothing powder.
It is further preferable that the auxiliary reducing blood lipid pressed candy formula are as follows: 6 parts of radish seed, 3 parts of Radix Salviae Miltiorrhizae, 9 parts of hawthorn,
3 parts of Radix Notoginseng, 4 parts of silicified microcrystalline cellulose, 0.1 part of magnesium stearate, 0.36 part of film coating powder.
The auxiliary reducing blood lipid pressed candy, it is characterised in that: manufacture craft the following steps are included:
(1) up-to-standard radish seed medicinal material is taken, after soaking in water 1-3h, extraction 3 times is boiled with 5-10 times of water heating, often
Secondary 1.5h, filtering, merging filtrate are concentrated under reduced pressure, and adding ethyl alcohol to alcohol content is 60%-80%, is stood, and filtrate is collected in filtration, subtract
Pressure concentration, dry radish seed extract；
(2) up-to-standard red rooted salvia is taken, the ethyl alcohol (v/w) of the 5-10 times of 80%-95% measured is added, is heated to reflux 2
It is secondary, each 2h；The dregs of a decoction add the ethyl alcohol of the 5-8 times of 30%-60% measured to be heated to reflux 1.5h, extracting solution filtration, filtrate recycling ethanol
And be concentrated into right amount, it is spare；The dregs of a decoction add the 3-8 times of water measured to decoct 2h, decocting liquid filtration, and filtrate is concentrated into right amount, subtracts again after merging
Pressure concentration, dry Salvia root P.E；
(3) up-to-standard uctus Crataegi is taken, is separately added into the ethyl alcohol (v/w) for the 60%-80% that 5-10 times is measured, reflux mentions
It takes 2 times, extracts 2h every time, dry haw thorn extract after extracting solution concentration；
(4) after taking up-to-standard pseudo-ginseng to be ground into 10-24 mesh, the ethyl alcohol of the 5-10 times of 65%-75% measured is added
(v/w), refluxing extraction 3 times, each 2h merge ethanol extract, recycling design, dry Notogineng Extract after concentration；
(5) above-mentioned Notogineng Extract, Salvia root P.E, haw thorn extract, radish seed extract and silicified microcrystalline cellulose
Merge and is ground into 80-100 mesh after mixing；
(6) while stirring spray 30%-80% ethanol solution to mixed material expert pinch it is agglomerating, it is light pressure i.e. dissipate humidity
Degree；
(7) above-mentioned softwood is pelletized through oscillating granulator, damp granules are set dry in 60 DEG C of baking ovens；
(8) particle after drying is screened out into bulky grain through No. 2 pharmacopeia, then screens out fine particle through No. 4, leave centre
The more uniform part of particle；
(9) magnesium stearate powder (120-200 mesh) is added to be uniformly mixed；
(10) tablet press machine loading is adjusted to slice weight 0.5-0.6g, and controlling pressure presses tabletting hardness in 50N or so
Piece；
(11) coating powder is configured to 10% solution, pressed candy is coated through efficient spray, is dispensed after coating,
It is irradiated after sterilizing up to finished product.
The auxiliary reducing blood lipid pressed candy, it is characterised in that: the coating powder can for white, yellow, red,
The transparent or opaque stomach dissolution type or enteric solubility or slow control release type coating powder of the colors such as blue, brown, black.
The beneficial effects of the present invention are:
Auxiliary reducing blood lipid pressed candy provided by the present invention, contains the medicinal ingredients such as radish seed, Radix Salviae Miltiorrhizae, hawthorn, Radix Notoginseng；
Pseudo-ginseng blood-circulation-invigovating stagnation resolvation, lipid-lowering effect are the most obvious；Radix Salviae Miltiorrhizae enriching yin and nourishing kidney, cool blood clear away heart-fire, and can reinforce the reducing blood lipid function of Radix Notoginseng
Energy；Radish seed help digestion and eliminate flatulence, clearing heat and eliminating phlegm being capable of the secondary simultaneous disease of combination therapy；Hawthorn digesting stomach invigorating, invigorating spleen to remove dampness, promoting the circulation of qi dissipate
The stasis of blood changes turbid lipid-loweringing, being capable of coordinating the drug actions of a prescription；Four traditional Chinese medicine material is used in combination, and invigorating the spleen, the liver kidney that reconciles supplement liver by whole maintenance
Gas improves interior environment, clearing damp resolving sputum, treating both manifestation and root cause of disease.Auxiliary reducing blood lipid pressed candy provided by the present invention is a complies with greatly
The health-oriented products of the healthy tendency of the day.
Specific embodiment
As described below is only a specific embodiment of the invention, but scope of protection of the present invention is not limited thereto, any
Those skilled in the art within the technical scope disclosed by the invention, can without the variation that creative work is expected or
Replacement, should be covered by the protection scope of the present invention.Therefore, protection scope of the present invention should be limited with claims
Subject to fixed protection scope.
Embodiment 1:
A kind of auxiliary reducing blood lipid pressed candy, formula are as follows: 1.5 parts of radish seed, 3 parts of Radix Salviae Miltiorrhizae, 12 parts of hawthorn, 9 parts of Radix Notoginseng,
6 parts of silicified microcrystalline cellulose, 0.02 part of magnesium stearate, 0.1 part of the opaque enteric solubility film coating powder of yellow.Its manufacture craft packet
Include following steps:
(1) up-to-standard radish seed medicinal material is taken, after soaking in water 1h, boils extraction 3 times with 5 times of water heating, every time
1.5h, filtering, merging filtrate are concentrated under reduced pressure, and adding ethyl alcohol to alcohol content is 60%, is stood, and filtrate is collected in filtration, are concentrated under reduced pressure,
Dry radish seed extract；
(2) up-to-standard red rooted salvia is taken, 80% ethyl alcohol (v/w) of 5 times of amounts are added, are heated to reflux 2 times, every time
2h；The dregs of a decoction add 30% ethyl alcohol of 5 times of amounts to be heated to reflux 1.5h, and extracting solution filtration, filtrate recycling ethanol is simultaneously concentrated into right amount, standby
With；The dregs of a decoction add the water of 3 times of amounts to decoct 2h, and decocting liquid filtration, filtrate is concentrated into right amount, is concentrated under reduced pressure again after merging, dry Radix Salviae Miltiorrhizae
Extract；
(3) take up-to-standard uctus Crataegi, be separately added into 5 times amount 60% ethyl alcohol (v/w), refluxing extraction 2 times, often
Secondary extraction 2h, dry haw thorn extract after extracting solution concentration；
(4) after taking up-to-standard pseudo-ginseng to be ground into 10 mesh, 65% ethyl alcohol (v/w) of 5 times of amounts is added, reflux mentions
It takes 3 times, each 2h, merges ethanol extract, recycling design, dry Notogineng Extract after concentration；
(5) above-mentioned radish seed extract, Salvia root P.E, haw thorn extract, Notogineng Extract and silicified microcrystalline cellulose
Merge and is ground into 80 mesh after mixing；
(6) while stirring sprinkling 30% ethanol solution to mixed material expert pinch it is agglomerating, it is light pressure i.e. dissipate moist degree；
(7) above-mentioned softwood is pelletized through oscillating granulator, damp granules are set dry in 60 DEG C of baking ovens；
(8) particle after drying is screened out into bulky grain through No. 2 pharmacopeia, then screens out fine particle through No. 4, leave centre
The more uniform part of particle；
(9) magnesium stearate powder (120 mesh) is added to be uniformly mixed；
(10) tablet press machine loading is adjusted to slice weight 0.5g, and controlling pressure makes tabletting hardness carry out tabletting in 50N or so；
(11) coating powder is configured to 10% solution, pressed candy is coated through efficient spray, is dispensed after coating,
It is irradiated after sterilizing up to finished product.
Embodiment 2:
A kind of auxiliary reducing blood lipid pressed candy, formula are as follows: 6 parts of radish seed, 3 parts of Radix Salviae Miltiorrhizae, 9 parts of hawthorn, 3 parts of Radix Notoginseng, silicon
Change 4 parts of microcrystalline cellulose, 0.1 part of magnesium stearate, 0.36 part of white clear stomach dissolution type film coating powder.Its manufacture craft include with
Lower step:
(1) up-to-standard radish seed medicinal material is taken, after soaking in water 2h, boils extraction 3 times with 8 times of water heating, every time
1.5h, filtering, merging filtrate are concentrated under reduced pressure, and adding ethyl alcohol to alcohol content is 80%, is stood, and filtrate is collected in filtration, are concentrated under reduced pressure,
Dry radish seed extract；
(2) up-to-standard red rooted salvia is taken, 95% ethyl alcohol (v/w) of 7 times of amounts are added, are heated to reflux 2 times, every time
2h；The dregs of a decoction add 50% ethyl alcohol of 7 times of amounts to be heated to reflux 1.5h, and extracting solution filtration, filtrate recycling ethanol is simultaneously concentrated into right amount, standby
With；The dregs of a decoction add the water of 5 times of amounts to decoct 2h, and decocting liquid filtration, filtrate is concentrated into right amount, is concentrated under reduced pressure again after merging, dry Radix Salviae Miltiorrhizae
Extract；
(3) take up-to-standard uctus Crataegi, be separately added into 8 times amount 70% ethyl alcohol (v/w), refluxing extraction 2 times, often
Secondary extraction 2h, dry haw thorn extract after extracting solution concentration；
(4) after taking up-to-standard pseudo-ginseng to be ground into 24 mesh, 70% ethyl alcohol (v/w) of 8 times of amounts is added, reflux mentions
It takes 3 times, each 2h, merges ethanol extract, recycling design, dry Notogineng Extract after concentration；
(5) above-mentioned radish seed extract, Salvia root P.E, haw thorn extract, Notogineng Extract and silicified microcrystalline cellulose
Merge and is ground into 100 mesh after mixing；
(6) while stirring sprinkling 60% ethanol solution to mixed material expert pinch it is agglomerating, it is light pressure i.e. dissipate moist degree；
(7) above-mentioned softwood is pelletized through oscillating granulator, damp granules are set dry in 60 DEG C of baking ovens；
(8) particle after drying is screened out into bulky grain through No. 2 pharmacopeia, then screens out fine particle through No. 4, leave centre
The more uniform part of particle；
(9) magnesium stearate powder (200 mesh) is added to be uniformly mixed；
(10) tablet press machine loading is adjusted to slice weight 0.55g, and controlling pressure makes tabletting hardness carry out tabletting in 50N or so；
(11) coating powder is configured to 10% solution, pressed candy is coated through efficient spray, is dispensed after coating,
It is irradiated after sterilizing up to finished product.
Embodiment 3:
A kind of auxiliary reducing blood lipid pressed candy, formula are as follows: 12 parts of radish seed, 15 parts of Radix Salviae Miltiorrhizae, 3 parts of hawthorn, 1 part of Radix Notoginseng,
Opaque 0.6 part of the slow control release type film coating powder of 1.5 parts of silicified microcrystalline cellulose, 0.15 part of magnesium stearate, brown.It makes work
Skill the following steps are included:
(1) up-to-standard radish seed medicinal material is taken, after soaking in water 3h, boils extraction 3 times with 10 times of water heating, every time
1.5h, filtering, merging filtrate are concentrated under reduced pressure, and adding ethyl alcohol to alcohol content is 70%, is stood, and filtrate is collected in filtration, are concentrated under reduced pressure,
Dry radish seed extract；
(2) up-to-standard red rooted salvia is taken, 90% ethyl alcohol (v/w) of 10 times of amounts are added, are heated to reflux 2 times, every time
2h；The dregs of a decoction add 60% ethyl alcohol of 8 times of amounts to be heated to reflux 1.5h, and extracting solution filtration, filtrate recycling ethanol is simultaneously concentrated into right amount, standby
With；The dregs of a decoction add the water of 8 times of amounts to decoct 2h, and decocting liquid filtration, filtrate is concentrated into right amount, is concentrated under reduced pressure again after merging, dry Radix Salviae Miltiorrhizae
Extract；
(3) take up-to-standard uctus Crataegi, be separately added into 10 times amount 80% ethyl alcohol (v/w), refluxing extraction 2 times,
2h, dry haw thorn extract after extracting solution concentration are extracted every time；
(4) after taking up-to-standard pseudo-ginseng to be ground into 10 mesh, 75% ethyl alcohol (v/w) of 10 times of amounts, reflux is added
It extracts 3 times, each 2h, merges ethanol extract, recycling design, dry Notogineng Extract after concentration；
(5) above-mentioned radish seed extract, Salvia root P.E, haw thorn extract, Notogineng Extract and silicified microcrystalline cellulose
Merge and is ground into 80 mesh after mixing；
(6) while stirring sprinkling 80% ethanol solution to mixed material expert pinch it is agglomerating, it is light pressure i.e. dissipate moist degree；
(7) above-mentioned softwood is pelletized through oscillating granulator, damp granules are set dry in 60 DEG C of baking ovens；
(8) particle after drying is screened out into bulky grain through No. 2 pharmacopeia, then screens out fine particle through No. 4, leave centre
The more uniform part of particle；
(9) magnesium stearate powder (200 mesh) is added to be uniformly mixed；
(10) tablet press machine loading is adjusted to slice weight 0.6g, and controlling pressure makes tabletting hardness carry out tabletting in 50N or so；
(11) coating powder is configured to 10% solution, pressed candy is coated through efficient spray, is dispensed after coating,
It is irradiated after sterilizing up to finished product.
Embodiment 4: the influence to rat hyperlipemia
Applicant has carried out effect to the extractive composition of formula described in above-described embodiment 2 and technique (1)-(5) preparation
Verification test, test result are as follows:
1 experimental material
1.1 extractive compositions, are made by oneself by our unit, chocolate brown powder.
1.2 experiment reagents: total cholesterol kit, triacylglycerol kit, low density lipoprotein cholesterol kit are high
Density lipoprotein-cholesterol kit builds up Bioengineering Research Institute's production, lot number 20170925 by Nanjing.
1.3 experimental animals: SPF grades of healthy male SD rats, 200 ± 20g of weight, by Guangdong Medical Lab Animal Center
It provides.
1.4 high lipid foods: 1.2% cholesterol, 0.2% sodium taurocholate, 6% lard, 0.2% propylthiouracil, 92.4%
Basal feed.
2 test methods
It is studied by the detection of Ministry of Public Health's function of health food with the regulating blood lipid action examination requirements in evaluation, rat is suitable
After 1 week should be raised, experimental animal is randomly divided by Normal group (5), prevention group high in fat (7) and mould high in fat according to weight
Type group (21) measures basic cholesterol, triglycerides before testing, Normal group gives basal feed and drinking water, high in fat
The test sample that prevention group is given high lipid food and dissolved through drinking water, hyperlipidemia model group gives high lipid food and drinking water is fed.3
Zhou Hou takes the big rat-tail blood of hyperlipidemia model group, measures the concentration of serum cholesterol and triglycerides；According to serum cholesterol level,
Hyperlipidemia model group rat is randomly divided into treatment group high in fat (11) and control group high in fat (10)；Control group high in fat continues to give
High lipid food and drinking water, the test sample that treatment group high in fat gives high lipid food and dissolves through drinking water.It is after 1 week, each group is big
After mouse weighing, through femoral artery sacrificed by exsanguination, groups of animals serum cholesterol and triglyceride levels are measured.
3 test results and analysis
The effect of 3.1 prevention rat hyperlipemias
Prevention group rat gives high lipid food and behind test sample 4 week of drinking water dissolution, observes itself and control group high in fat
The serum cholesterol and triglyceride levels difference condition of rat, the results are shown in Table 1:
Influence of 1 test sample of table to prevention group rat blood serum cholesterol and triglyceride levels (mmol/L)
It tests the 4th week, the serum cholesterol and triglyceride levels of control rats high in fat have compared with Normal group
It significantly improves, illustrates modeling success, test result is credible；The control group decline more high in fat of the serum cholesterol level of prevention group rat
24.71%, it is bright to illustrate that the test sample has the hyperlipidemia of rat for triglyceride levels control group decline 13.82% more high in fat
Aobvious prevention effect.
The therapeutic effect of 3.2 pairs of rat hyperlipemias
Rats in normal control group feeding basal feed and drinking water, control group high in fat continue to give high lipid food and drink
Water, the test sample that treatment group high in fat gives high lipid food and dissolves through drinking water, 1 week each test group of animals serum cholesterol of measurement
With triglyceride levels situation, the results are shown in Table 2:
Influence of 2 test sample of table to treatment group's rat blood serum cholesterol high in fat and triglyceride levels (mmol/L)
Control group high in fat and treatment group rat high in fat have formd apparent hyperlipemia before the treatment, after one week treatment,
The cholesterol and triglyceride levels for the treatment of group have obtained effective control, compared with the control group, have dropped 19.90% He respectively
20.28%, it is proved from data, which has certain treatment or remission effect to hyperlipemia.
Claims (5)
1. a kind of auxiliary reducing blood lipid pressed candy, it is characterized in that: the auxiliary reducing blood lipid pressed candy specifically includes following weight
The component of part: 1.5-12 parts of radish seed, 3-15 parts of Radix Salviae Miltiorrhizae, 3-12 parts of hawthorn, 1-9 parts of Radix Notoginseng, silicified microcrystalline cellulose 1.5-6
Part, 0.02-0.15 parts of magnesium stearate, 0.1-0.6 parts of film coating powder.
2. auxiliary reducing blood lipid pressed candy according to claim 1, which is characterized in that the auxiliary reducing blood lipid pressed candy
Fruit specifically includes the component of following parts by weight: 4-10 parts of radish seed, 3-9 parts of Radix Salviae Miltiorrhizae, 6-9 parts of hawthorn, 2-6 parts of Radix Notoginseng, silication are micro-
2-5 parts of crystalline cellulose, 0.05-0.1 parts of magnesium stearate, 0.15-0.45 parts of film coating powder.
3. auxiliary reducing blood lipid pressed candy according to claim 1, is preferably formulated are as follows: 6 parts of radish seed, 3 parts of Radix Salviae Miltiorrhizae,
9 parts of hawthorn, 3 parts of Radix Notoginseng, 4 parts of silicified microcrystalline cellulose, 0.1 part of magnesium stearate, 0.36 part of film coating powder.
4. auxiliary reducing blood lipid pressed candy according to claim 1 to 3, it is characterised in that: manufacture craft includes following step
It is rapid:
(1) up-to-standard radish seed medicinal material is taken, after soaking in water 1-3 h, extraction 3 times is boiled with 5-10 times of water heating, every time
1.5 h, filtering, merging filtrate are concentrated under reduced pressure, and adding ethyl alcohol to alcohol content is 60%-80%, is stood, and filtrate is collected in filtration, depressurize dense
Contracting, dry radish seed extract；
(2) it takes up-to-standard red rooted salvia, the ethyl alcohol (v/w) of the 5-10 times of 80%-95% measured is added, be heated to reflux 2 times, every time
2 h；The dregs of a decoction add the ethyl alcohol of the 5-8 times of 30%-60% measured to be heated to reflux 1.5 h, extracting solution filtration, and filtrate recycling ethanol is simultaneously concentrated into
In right amount, spare；The dregs of a decoction add the 3-8 times of water measured to decoct 2 h, decocting liquid filtration, and filtrate is concentrated into right amount, is concentrated under reduced pressure again after merging,
Dry Salvia root P.E；
(3) up-to-standard uctus Crataegi is taken, is separately added into the ethyl alcohol (v/w) for the 60%-80% that 5-10 times is measured, refluxing extraction 2 times,
2 h, dry haw thorn extract after extracting solution concentration are extracted every time；
(4) after taking up-to-standard pseudo-ginseng to be ground into 10-24 mesh, the ethyl alcohol (v/w) of the 5-10 times of 65%-75% measured is added,
Refluxing extraction 3 times, every time 2 h, merge ethanol extract, recycling design, dry Notogineng Extract after concentration；
(5) above-mentioned Notogineng Extract, Salvia root P.E, haw thorn extract, radish seed extract merge with silicified microcrystalline cellulose
80-100 mesh is ground into after mixing；
(6) while stirring spray 30%-80% ethanol solution to mixed material expert pinch it is agglomerating, it is light pressure i.e. dissipate moist degree；
(7) above-mentioned softwood is pelletized through oscillating granulator, damp granules are set dry in 60 DEG C of baking ovens；
(8) particle after drying is screened out into bulky grain through No. 2 pharmacopeia, then screens out fine particle through No. 4, leave intermediate particle
More uniform part；
(9) magnesium stearate powder (120-200 mesh) is added to be uniformly mixed；
(10) tablet press machine loading is adjusted to slice weight 0.5-0.6 g, and controlling pressure makes tabletting hardness carry out tabletting in 50 N or so；
(11) coating powder is configured to 10% solution, pressed candy is coated through efficient spray, is dispensed after coating, through spoke
According to after sterilizing up to finished product.
5. auxiliary reducing blood lipid pressed candy according to claim 1, it is characterised in that: the coating powder can be white
The transparent or opaque stomach dissolution type or enteric solubility or slow control release type packet of the colors such as color, yellow, red, blue, brown, black
Clothing powder.
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| CN110521845A (en) * | 2019-09-24 | 2019-12-03 | 广东粤微食用菌技术有限公司 | A kind of sargassum fusifome pressed candy and preparation method thereof |
| CN112042795A (en) * | 2019-06-06 | 2020-12-08 | 天津科技大学 | Pressed candy with weight-losing and lipid-lowering effects and preparation method thereof |
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