CN109662171A - The preparation method and application of black tea beverage containing yellow fast cry of certain animals oxidase active inhibitor - Google Patents
The preparation method and application of black tea beverage containing yellow fast cry of certain animals oxidase active inhibitor Download PDFInfo
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- CN109662171A CN109662171A CN201811609958.5A CN201811609958A CN109662171A CN 109662171 A CN109662171 A CN 109662171A CN 201811609958 A CN201811609958 A CN 201811609958A CN 109662171 A CN109662171 A CN 109662171A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/16—Tea extraction; Tea extracts; Treating tea extract; Making instant tea
- A23F3/163—Liquid or semi-liquid tea extract preparations, e.g. gels, liquid extracts in solid capsules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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Abstract
The invention discloses a kind of preparation method and application of black tea beverage containing yellow fast cry of certain animals oxidase active inhibitor.Include the following steps: S1, dark green tea is mixed according to a certain percentage with water after heat, obtain the dark green tea aqueous extract containing a certain amount of tea polyphenols and theabrownin；S2, the dark green tea aqueous extract that step S1 is obtained is removed into unwanted ingredient by membrane filtration, obtains dark green tea water Hydrolysis kinetics liquid；S3, the dark green tea water Hydrolysis kinetics liquid for obtaining step S2 obtain the black tea beverage containing yellow fast cry of certain animals oxidase active inhibitor by high-temperature heating treatment.Preparation method of the invention is simple and convenient, edible safety has no toxic side effect, and there is certain auxiliary therapeutic action, the product " small black mind " containing xanthine oxidase inhibitor has been produced in the present inventive method, and the pharmacological evaluation through Shenyang Pharmaceutical University confirms that energy conspicuousness inhibits the activity of xanthine oxidase.
Description
Technical field
The present invention relates to a kind of preparation method and application of black tea beverage, and in particular to one kind is containing yellow fast cry of certain animals oxidase active
The preparation method and application of the black tea beverage of inhibitor.
Background technique
For China's gout crowd close to 100,000,000, gout is to reach lithate after saturation degree since blood uric acid increases in human body at present
Crystallize and be precipitated at the soft tissues such as joint and kidney and bring severe pain, hyperuricemia become endanger human health killer it
One.
The treatment common two classes anti-trioxypurine drug of gout at present: one kind is that inhibition uric acid generates, such as Febustat, not fast
Alcohol etc. mainly inhibits the activity of xanthine oxidase, and xanthine oxidase is the catalyst of purine oxygenation synthesis uric acid, suppression
Make the synthesis that its activity just reduces uric acid；Another kind of is the drug for increasing uric acid excretion, and such as Benzbromarone prevents kidney to uric acid
Reabsorption is recycled, discharge is forced；The maximum deficiency of this two classes drug is that have serious side effect to liver kidney, sometimes to the damage of liver kidney
Evil is even greater than the damage of high lithemia, and the food and drug for finding without any side effects, safe anti-trioxypurine become when business
It is anxious.
Known tea polyphenols have strong antioxidant action, can effectively clear extra free radical, prevent cytopathy, enhance human body
Immunity protects liver kidney, and dark green tea is due to being full fermentation tea, and cool property substance catechin is largely converted to the theabrownin of warm nature in green tea
It is more preferable to the health-care effect of human body；It since tea is highly-safe food, can largely drink, therefore, be mentioned in dark green tea for a long time
Invention important process in object is taken to be allowed to generate xanthine oxidase activity inhibitor to reduce the synthesis of uric acid and then reduce urine
Acid, prevention and treatment gout have especially great meaning.
Summary of the invention
The object of the present invention is to provide a kind of black tea beverage containing yellow fast cry of certain animals oxidase active inhibitor and its preparation sides
Method and application make black tea extract generate xanthine oxidase activity inhibitor to reduce the synthesis of uric acid by important process
And then reduce uric acid, prevention and treatment gout.
The purpose of the present invention can be achieved through the following technical solutions: the dark green tea containing yellow fast cry of certain animals oxidase active inhibitor
The preparation method of drink, includes the following steps:
S1, it is heated after mixing dark green tea according to a certain percentage with water, obtains mentioning containing the dark green tea water of a certain amount of tea polyphenols and theabrownin
Take liquid；
S2, the dark green tea aqueous extract that step S1 is obtained is removed into unwanted ingredient by membrane filtration, obtains the extraction of dark green tea water
Refined liquid；
S3, the dark green tea water Hydrolysis kinetics liquid for obtaining step S2 are obtained by high-temperature heating treatment containing yellow fast cry of certain animals oxidation enzyme activity
The black tea beverage of property inhibitor.
It is 1:3-that the condition of heating extraction, which includes: the ratio of tealeaves and water, after wherein mixing dark green tea and water in step S1
200；The time of heating extraction is 30-180 minutes, and the temperature of heating extraction is 60-99 DEG C；Obtained dark green tea aqueous extract
1500-15000 mg/litre of polyphenol content；Dark brown 800-8000 mg/litre of cellulose content.
Wherein unwanted ingredient described in step S2 is the substance greater than 0.3 micron, and the aperture for filtering filter membrane used is
≤ 0.3 micron.
Wherein the condition of step S3 high temperature heating includes: that dark green tea water Hydrolysis kinetics liquid is packed into 10-1000 milliliters resistance to
Sealing in elevated temperature vessel；The temperature of high-temperature heating is 100-135 DEG C；The time of high-temperature heating is 5-240 minutes；High-temperature heating
Mode is that steam or water drench.
The dark green tea is selected from one or more of dark green teas such as Anhua dark green tea, Pu'er tea, six fort tea.
The application of the black tea beverage is mainly used for treating or preventing the food and medicine for leading to gout illness with high lithemia
In object.
Beneficial effects of the present invention: the preparation method of black tea beverage provided by the present invention will contain a certain amount of tea polyphenols
The dark green tea aqueous extract of (including theabrownin) removes unwanted substance through filtering, obtains using high-temperature heating containing yellow fast
The black tea beverage of purine oxidase active inhibitor, preparation method of the invention is simple and convenient, and edible safety has no toxic side effect, and has
It is " small black to have produced the product containing xanthine oxidase inhibitor in the present inventive method for certain auxiliary therapeutic action
Mind ", the pharmacological evaluation through Shenyang Pharmaceutical University confirms that energy conspicuousness inhibits the activity of xanthine oxidase.
Specific embodiment
The present invention and its specific embodiment are described in further detail below with reference to embodiment.
Dark green tea category full fermentation tea of the invention, such as Anhua dark green tea (Fu tea, thousand tael tea, black brick tea, tricuspid), Hubei blue bricks
Tea, four Sichuan-Tibet tea (brick tea), Gu Yi County, Anhui dark green tea (peace tea), Yunnan Pu'er cooked tea, Guangxi Liu Bao tea and Shaanxi dark green tea (Fu tea)
Deng.
The present invention includes the following steps:
S1, extract dark green tea aqueous extract: the ratio of dark green tea and water are as follows: dark green tea is 1 part: water is 3-200 parts and mixes heating
It extracts, the temperature of heating extraction is 60-99 degrees Celsius；The time of heating extraction is 30 minutes -180 minutes, obtains dark green tea water
The polyphenol content mg/litre of 1500 mg/litre -15000 of extracting solution；Dark brown 800 mg/litre -8000 milligram of cellulose content/
It rises；
S2, extract dark green tea water refined liquid: the filter removal by aperture less than or equal to 0.3 micron is all greater than 0.3 micron
Substance is not needed, dark green tea water Hydrolysis kinetics liquid is obtained；
S3, deep processing refined liquid: filtered dark green tea water Hydrolysis kinetics liquid is packed into the resistance to height such as 10-1000 milliliters of bottle or tank
In warm sealing container；It is placed in steam or water leaching heating cabinet, the temperature of high-temperature heating is 100-135 degrees Celsius, high-temperature heating
Time is 5-240 minutes, after high-temperature heating, contains xanthine oxidase in the dark green tea water Hydrolysis kinetics liquid according to made from the above method
Change activity inhibitor.
An example of the present invention is given below.
Example one, Anhua dark green tea
One, Anhua dark green tea tealeaves and water Hybrid Heating obtain tealeaves aqueous extract
1, ingredient: by 5 kilograms of Anhua dark green teas, 100 liters of pure water (aseptic filtration) are blended in indirect heating tank；
2, heating extraction: the material prepared is heated to 90 degrees Celsius of constant temperature and is extracted 60 minutes；
3, the polyphenol content of the dark green tea aqueous extract obtained is 4000 mg/litres, and dark brown cellulose content is 2000 mg/litres.
Two, it filters
By dark green tea aqueous extract by the membrane filtration in 0.25 micron of aperture, dark green tea water Hydrolysis kinetics liquid is obtained.
Three, it is heated at high temperature
High-temperature heating: the vial inner cover that dark green tea water Hydrolysis kinetics liquid is packed into 50 milliliters is next, in merging water leaching sterilizing cabinet, adds
Temperature is kept for 15 minutes to 120 DEG C.
By above-mentioned practical operation, xanthine oxidase activity inhibitor can get in the water Hydrolysis kinetics liquid of dark green tea.
Example two, Guangxi Liu Bao tea
One, dark green tea tealeaves and water Hybrid Heating, which are extracted, obtains dark green tea aqueous extract
1, ingredient: by 20 kilograms of dark green teas, 300 liters of pure water are blended in heating tank；
2, heating extraction: the material prepared is heated to 95 DEG C of constant temperature extractions and obtains tealeaves aqueous extract within 90 minutes；
3, dark green tea aqueous extract is obtained, 4200 mg/litre containing tea polyphenols；Containing dark brown 2300 mg/litre of cellulose content.
Two, it filters
Dark green tea aqueous extract to be filtered by the filter membrane in 0.3 micron of aperture, removal is greater than 0.3 micron of unwanted ingredient,
Obtain dark green tea water Hydrolysis kinetics liquid.
Three, it is heated at high temperature
1, it is heated at high temperature: dark green tea water Hydrolysis kinetics liquid is fitted into after being sealed in 310 milliliters of tinplate pop can, is placed in steam-type
High-temperature heating in heating cabinet；
2,130 degrees Celsius are heated to, is kept for 30 minutes.
By above-mentioned practical operation, xanthine oxidase activity inhibitor can get in the water Hydrolysis kinetics liquid of dark green tea.
The dark green tea Hydrolysis kinetics liquid prepared through embodiment send Shenyang spice university to examine, and show that experimental data is as follows:
Instrument: Spectramax M2 type microplate reader (Shenyang Technology Service Co., Ltd, Ningyuan)
50uL, 100uL liquid-transfering gun (are purchased from big dragon Xing Chuan laboratory apparatus Co., Ltd)
Reagent: black tea beverage prepared by the present invention
It is not fast to hold in the mouth or the eyes purine alcohol (purchased from Dalian U.S. logical sequence)
XOD kit (is purchased from the enzyme-linked Biotechnology Co., Ltd in Shanghai)
Black tea beverage prepared by the present invention is used pure water to dilute 2 times, 4 times and 5 times as 3 groups of sample (every group of weights by the experiment respectively
Repetition measurement is 6 times fixed), final experimental result is detailed in following table:
Black tea beverage can inhibit to conspicuousness the activity of XOD it can be seen from statistic analysis result.
Claims (6)
1. the preparation method of the black tea beverage containing yellow fast cry of certain animals oxidase active inhibitor, includes the following steps:
S1, it is heated after mixing dark green tea according to a certain percentage with water, obtains mentioning containing the dark green tea water of a certain amount of tea polyphenols and theabrownin
Take liquid；
S2, the dark green tea aqueous extract that step S1 is obtained is removed into unwanted ingredient by membrane filtration, obtains the extraction of dark green tea water
Refined liquid；
S3, the dark green tea water Hydrolysis kinetics liquid for obtaining step S2 are obtained by high-temperature heating treatment containing yellow fast cry of certain animals oxidation enzyme activity
The black tea beverage of property inhibitor.
2. preparation method according to claim 1, the condition of heating extraction after wherein mixing dark green tea with water in step S1
The ratio for including: tealeaves and water is 1:3-200；The time of heating extraction is 30-180 minutes, and the temperature of heating extraction is 60-
99℃；1500-15000 mg/litre of polyphenol content of obtained dark green tea aqueous extract；Dark brown 800-8000 milli of cellulose content
Grams per liter.
3. preparation method according to claim 1, wherein unwanted ingredient described in step S2 is greater than 0.3 micron
Substance, the aperture for filtering filter membrane used is≤0.3 micron.
4. preparation method according to claim 1, wherein the condition of step S3 high temperature heating includes: to extract dark green tea water
Refined liquid is packed into sealing in 10-1000 milliliters of high-temperature resistant container；The temperature of high-temperature heating is 100-135 DEG C；High-temperature heating
Time is 5-240 minutes；The mode of high-temperature heating is that steam or water drench.
5. preparation method described in -4 according to claim 1, wherein the dark green tea is selected from Anhua dark green tea, Pu'er tea, six fort tea etc.
One or more of dark green tea.
6. the application of black tea beverage as claimed in claim 5, being mainly used for treating or preventing leads to gout illness with high lithemia
Food and drug in.
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| CN201811609958.5A CN109662171A (en) | 2018-12-27 | 2018-12-27 | The preparation method and application of black tea beverage containing yellow fast cry of certain animals oxidase active inhibitor |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113383837A (en) * | 2021-06-16 | 2021-09-14 | 广东省七寸贸易有限公司 | Preparation method of dark tea extract, product and application |
| CN114711313A (en) * | 2020-12-05 | 2022-07-08 | 香港泾渭茯茶(国际)有限公司 | Tea extract composition and preparation method and application thereof |
| CN116803295A (en) * | 2023-06-19 | 2023-09-26 | 成都六然医疗科技有限公司 | Uric acid reducing composition and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113383837A (en) * | 2021-06-16 | 2021-09-14 | 广东省七寸贸易有限公司 | Preparation method of dark tea extract, product and application |
| CN116803295A (en) * | 2023-06-19 | 2023-09-26 | 成都六然医疗科技有限公司 | Uric acid reducing composition and preparation method thereof |
| CN116803295B (en) * | 2023-06-19 | 2024-05-03 | 成都六然医疗科技有限公司 | Uric acid reducing composition and preparation method thereof |
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Application publication date: 20190423 |