CN109662039A - Based on multi-mode visible light mouse intelligent experiment method and system - Google Patents
Based on multi-mode visible light mouse intelligent experiment method and system Download PDFInfo
- Publication number
- CN109662039A CN109662039A CN201811563626.8A CN201811563626A CN109662039A CN 109662039 A CN109662039 A CN 109662039A CN 201811563626 A CN201811563626 A CN 201811563626A CN 109662039 A CN109662039 A CN 109662039A
- Authority
- CN
- China
- Prior art keywords
- mouse
- visible light
- mode
- different
- behavioural information
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002474 experimental method Methods 0.000 title claims abstract description 67
- 238000000034 method Methods 0.000 title claims abstract description 29
- 230000003542 behavioural effect Effects 0.000 claims abstract description 38
- 230000000638 stimulation Effects 0.000 claims abstract description 28
- 239000003651 drinking water Substances 0.000 claims abstract description 11
- 235000020188 drinking water Nutrition 0.000 claims abstract description 11
- 230000033001 locomotion Effects 0.000 claims abstract description 11
- 238000004458 analytical method Methods 0.000 claims description 14
- 238000013473 artificial intelligence Methods 0.000 claims description 10
- 230000008859 change Effects 0.000 claims description 2
- 241000699666 Mus <mouse, genus> Species 0.000 abstract description 142
- 230000006399 behavior Effects 0.000 abstract description 51
- 241000699670 Mus sp. Species 0.000 abstract description 28
- 230000033764 rhythmic process Effects 0.000 abstract description 21
- 210000005036 nerve Anatomy 0.000 abstract description 12
- 210000004556 brain Anatomy 0.000 abstract description 8
- 102000004169 proteins and genes Human genes 0.000 abstract description 6
- 108090000623 proteins and genes Proteins 0.000 abstract description 6
- 230000015654 memory Effects 0.000 abstract description 5
- 230000004936 stimulating effect Effects 0.000 abstract description 5
- 230000009471 action Effects 0.000 description 10
- 238000011160 research Methods 0.000 description 10
- 230000006870 function Effects 0.000 description 8
- 210000003792 cranial nerve Anatomy 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000013598 vector Substances 0.000 description 4
- 210000003027 ear inner Anatomy 0.000 description 3
- 230000005611 electricity Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 230000027288 circadian rhythm Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000013401 experimental design Methods 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000009329 sexual behaviour Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 230000006886 spatial memory Effects 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K29/00—Other apparatus for animal husbandry
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Abstract
The invention discloses one kind to be based on multi-mode visible light mouse intelligent experiment method and system, wherein this method comprises: configuration multi-mode visible light source, and multi-mode visible light source is initialized；Multi-mode visible light source is controlled to the visible light signal of mouse transmitting different mode, and records the behavioural information of mouse mouse under the visible light signal of different mode；The behavioural information of mouse is analyzed and processed to obtain the current behavior characteristic of mouse, carrying out automatic drinking water stimulation and automatic feedback to mouse according to current behavior characteristic and predefined experimental paradigm stimulates.The different Behavioral features that this method is generated under the influence of multi-mode visible light by stimulation by experiment mice, the long period of experiments for not being operated manually interference by experiment mice is realized with automation stimulating course, reaches the purpose of stimulation is by experiment mice nerve, influence rhythm and pace of moving things regulation, protein expression, stimulus movement nerve and brain area Memory control.
Description
Technical field
It is the present invention relates to field of bioexperiment technology, in particular to a kind of based on multi-mode visible light mouse intelligence experiment side
Method and system.
Background technique
In Bioexperiment system, mouse experiment has very great meaning.A large amount of mouse are used for the row of cranial nerve science
To learn in research, experimental data and first hand data are provided for the progress of Neuscience.
Mice behavior experimental facilities function in the related technology is excessively single, and needs a large amount of manual operations.Mainly have
Common cultivation mouse cage, open sports ground, fixed sports ground, eight arm labyrinths etc..There are many factor for influencing mouse behavior, function
The equipment of dispersion is unable to satisfy the demand of further complex experiment relevant to the rhythm and pace of moving things.And mouse is quick to the taste of the mankind and touch
Sense, a large amount of manpowers that rely on are tested, and the uncertainty of Behaviors survey and nonrepeatability is caused to be significantly increased.It is existing small
Major drawbacks existing for mouse Behaviors survey.
The development of cranial nerve experiment needs new laboratory facilities and method to open up, and artificial intelligence and automatic control technology
Progress, these new demands may be implemented.Nobel prize's soul in 2017 is awarded discovery control and saves round the clock
Jeffrey C.Hall, the Michael Rosbash and Michael W.Young of rule.Rhythm and pace of moving things research has been assigned more deep and broad
Meaning and mode are controlled from past single dimension light switch, become to combine visible illumination, mouse drinking water is fed, rewards and punishments
The multi-modes control problems such as stimulation, but there are still many problems for the control experiment of multi-mode.
The core of existing mice behavior experiment is common cultivation mouse cage, and mouse most of time is lived wherein.According to
Different experimental designs, laboratory technician take out mouse from common cultivation mouse cage, using different simple function experimental facilities into
Row experiment.Mainly there is the rhythm and pace of moving things case for supporting the research of the mouse rhythm and pace of moving things, support more mouse with the open fortune of cage social attribute research
Dynamic field, the fixation sports ground for supporting locomitivity research, the eight arm labyrinths for supporting spatial memory research and water maze support prize
Punish the shock case etc. of memory experiment.Influence mouse behavior factor it is very much, function dispersion equipment be unable to satisfy further with section
Restrain the demand of relevant complex experiment.Mouse is sensitive to the taste of the mankind and touch, and a large amount of dependence manpowers are tested, and causes to go
It is significantly increased to learn uncertainty and the nonrepeatability of experiment.
Existing experimental system exists as following drawbacks:
1, different feedback control/stimulus modalities can not be adjusted according to the behavior of mouse, keep experimental design excessively single, nothing
Method carries out complex experiment.
2, it needs manpower intervention setting mouse living environment and adds food (the food prize in such as common eight arm labyrinth
It encourages, needs laboratory technician that observation/addition process is repeated).The behavior of people's operation and smell, influence whether the behavior of mouse,
Uncertainty is brought to experiment.
3, the rhythm and pace of moving things of mouse can not be controlled with the visible light of different frequency, stroboscopic and modulating characteristic
With existing mice behavior rhythm and pace of moving things experimental facilities, for mouse rhythm and pace of moving things case.Mouse rhythm and pace of moving things case is generally three layers, often
Layer can place 6 mice rearing cages, and every layer has lighting unit.By artificial or PLC technology power switch, control is shone
The opening and closing of bright unit adjusts the biorhythmic cycle of mouse.Smell between existing mouse rhythm and pace of moving things case there are mouse survival spaces small, mouse
It can interfere with each other, Lighting control has a single function, the problems such as can only realizing basic opening and closing function.Nearest Neuscience discovery,
The visible light of the different luminous frequencies of visible illumination system, stroboscopic and modulating characteristic has different shadows to mouse cranial nerve
It rings.Existing mouse rhythm and pace of moving things case cannot achieve the experiment in these fields.
Summary of the invention
The present invention is directed to solve at least some of the technical problems in related technologies.
For this purpose, an object of the present invention is to provide one kind to be based on multi-mode visible light mouse intelligent experiment method, it should
The different Behavioral features that method is generated under the influence of multi-mode visible light by stimulation by experiment mice, were stimulated with automation
Cheng Shixian is not operated manually the long period of experiments of interference by experiment mice, reaches stimulation by experiment mice nerve, the influence rhythm and pace of moving things
The purpose of regulation, protein expression, stimulus movement nerve and brain area Memory control.
It is a kind of based on multi-mode visible light mouse intelligence experimental system it is another object of the present invention to propose.
In order to achieve the above objectives, one aspect of the present invention embodiment proposes a kind of real based on multi-mode visible light mouse intelligence
Proved recipe method, comprising: configuration multi-mode visible light source, and the multi-mode visible light source is initialized；Described in control
Multi-mode visible light source emits mouse the visible light signal of different mode, and records the mouse in the different mode
The behavioural information of the mouse under visible light signal；The behavioural information of the mouse is analyzed and processed to obtain the mouse
Current behavior characteristic carries out automatic drinking water stimulation to the mouse according to the current behavior characteristic and predefined experimental paradigm
It is stimulated with automatic feedback.
The embodiment of the present invention based on multi-mode visible light mouse intelligent experiment method, by stimulating by experiment mice more
The different Behavioral features generated under the influence of mode visible light are realized with automation stimulating course and are not grasped manually by experiment mice
Make the long period of experiments interfered, reaches stimulation by experiment mice nerve, influence rhythm and pace of moving things regulation, protein expression, stimulus movement nerve
The purpose of with brain area Memory control.
In addition, according to the above embodiment of the present invention can also be had based on multi-mode visible light mouse intelligent experiment method
Additional technical characteristic below:
Further, in one embodiment of the invention, the visible light signal of the different mode includes: different frequencies
Rate, the visible light signal of different stroboscopics and different modulating characteristic.
Further, in one embodiment of the invention, the mouse is acquired from different perspectives by multiple cameras
Behavioural information and stored, the behavioural information of the collected mouse is carried out automatically by artificial intelligence analysis's software
Analysis processing.
Further, in one embodiment of the invention, the behavioural information of the mouse is analyzed and processed and includes:
3D reconstruct, mouse skeleton extract, motion state assessment.
Further, in one embodiment of the invention, the predefined experimental paradigm can pass through programming interface
It is modified.
In order to achieve the above objectives, another aspect of the present invention embodiment proposes a kind of based on multi-mode visible light mouse intelligence
Experimental system, comprising: visible light source module, for configuring multi-mode visible light source, and to the multi-mode visible light light
Source is initialized；Generation module, for controlling the multi-mode visible light source to the visible light of mouse transmitting different mode
Signal, and record the behavioural information of mouse mouse under the visible light signal of the different mode；Automatically control mould
Block is analyzed and processed to obtain the current behavior characteristic of the mouse for the behavioural information to the mouse, be worked as according to described
Preceding behavioral trait and predefined experimental paradigm, which carry out automatic drinking water stimulation and automatic feedback to the mouse, to stimulate.
The embodiment of the present invention based on multi-mode visible light mouse intelligence experimental system, by multi-mode visible light to mouse
The control and influence of the rhythm and pace of moving things and nervous system realize that mouse feeds and stimulates automatically by built-in food stimulus control module,
The influence that manual operation tests mice behavior is reduced, mouse behavior acquisition module (camera and the artificial intelligence at top are passed through
Software can be analyzed), mouse current behavior characteristic is obtained, according to the rule that experimental paradigm control module defines, controls food stimulus
Control module carries out automatic feedback stimulation to mouse behavior.
In addition, according to the above embodiment of the present invention can also be had based on multi-mode visible light mouse intelligence experimental system
Additional technical characteristic below:
Further, in one embodiment of the invention, the visible light signal of the different mode includes: different frequencies
Rate, the visible light signal of different stroboscopics and different modulating characteristic.
Further, in one embodiment of the invention, the mouse is acquired from different perspectives by multiple cameras
Behavioural information and stored, the behavioural information of the collected mouse is carried out automatically by artificial intelligence analysis's software
Analysis processing.
Further, in one embodiment of the invention, the behavioural information of the mouse is analyzed and processed and includes:
3D reconstruct, mouse skeleton extract, motion state assessment.
Further, in one embodiment of the invention, the predefined experimental paradigm can pass through programming interface
It is modified.
The additional aspect of the present invention and advantage will be set forth in part in the description, and will partially become from the following description
Obviously, or practice through the invention is recognized.
Detailed description of the invention
Above-mentioned and/or additional aspect and advantage of the invention will become from the following description of the accompanying drawings of embodiments
Obviously and it is readily appreciated that, in which:
Fig. 1 is according to one embodiment of the invention based on multi-mode visible light mouse intelligent experiment method flow chart；
Fig. 2 is according to one embodiment of the invention based on multi-mode visible light mouse intelligent experiment method structural block diagram；
Fig. 3 is according to one embodiment of the invention based on multi-mode visible light mouse intelligence experimental system structural representation
Figure.
Specific embodiment
The embodiment of the present invention is described below in detail, examples of the embodiments are shown in the accompanying drawings, wherein from beginning to end
Same or similar label indicates same or similar element or element with the same or similar functions.Below with reference to attached
The embodiment of figure description is exemplary, it is intended to is used to explain the present invention, and is not considered as limiting the invention.
Describe to propose according to embodiments of the present invention with reference to the accompanying drawings based on multi-mode visible light mouse intelligence experiment side
Method and system.
Describe to propose according to embodiments of the present invention with reference to the accompanying drawings first is intelligently tested based on multi-mode visible light mouse
Method.
Fig. 1 is according to one embodiment of the invention based on multi-mode visible light mouse intelligent experiment method flow chart.
As shown in Figure 1, should based on multi-mode visible light mouse intelligent experiment method the following steps are included:
In step s101, multi-mode visible light source is configured, and multi-mode visible light source is initialized.
Further, in one embodiment of the invention, multi-mode visible light source refers to the visible of different mode
Optical signal may include: different frequency, the visible light signal of different stroboscopics and different modulating characteristic.
Specifically, the LED that freely can define and automatically configure modulation system, intensity and frequency control parameters by software is more
Mode visible light occurrence of equipment.
In step s 102, control multi-mode visible light source emits mouse the visible light signal of different mode, and remembers
Record the behavioural information of mouse mouse under the visible light signal of different mode.
It is understood that under mouse is under the visible light signal of different mode, can to mouse behavior, nerve, albumen and
The various aspects such as brain electricity can have an impact, and then can generate different mouse behavioural informations.It is believed that mouse reception multi-mode can
Light-exposed light source is as input, and the mouse behavior of generation is as output.
In step s 103, the behavioural information of mouse is analyzed and processed to obtain the current behavior characteristic of mouse, according to
Current behavior characteristic and predefined experimental paradigm, which carry out automatic drinking water stimulation and automatic feedback to mouse, to stimulate.
Further, in one embodiment of the invention, the row of mouse is acquired from different perspectives by multiple cameras
It for information and is stored, the behavioural information of collected mouse is carried out at analysis automatically by artificial intelligence analysis's software
Reason.
It is understood that the behavioural information of the mouse generated in step s 102, mouse behavior acquisition module can lead to
Cross the multidate information that multiple cameras acquire mouse from different angles, and by these multidate informations by video and in the form of carry out
Storage, is analyzed for artificial intelligence software, and software and hardware combining analyzes the behavioural information of mouse, wherein divides mouse behavior
Analysis includes but is not limited to 3D reconstruct, mouse skeleton extract, motion state assessment etc..It is believed that the behavior that input is mouse is believed
Breath, exports the description vectors for mouse behavior.
Further, predetermined according to the current behavior characteristic of mouse by obtaining the current behavior characteristic of mouse after analysis
The experimental paradigm of justice, which carries out automatic drinking water stimulation and automatic feedback to mouse, to stimulate.Wherein, predefined experimental paradigm is by testing
Normal form control module provides, and experimental paradigm control module provides programming interface for researcher, and researcher can pass through programming
Interface is modified experimental paradigm.Determine whether mouse needs by predefined experimental paradigm and mouse current behavior characteristic
Carry out the stimulation of food and water.
Further, in an embodiment of the present invention, as shown in Fig. 2, carrying out drinking water stimulation to mouse is pierced by food
Swash what control module was realized, is the system that automatic foodstuff delivering feeds water, by the collective effect of modules, based on the analysis results automatically
It carries out, does not need artificial interference, reduce influence of the human factor to experimental result.
Further, automatic feedback stimulation can also be generated according to the current behavior characteristic of mouse, feedback transmission is gone out to arrive
Multi-mode visible light source exports multi-mode visible light dominant vector to LED and controls equipment.It is considered that input is working as mouse
Preceding behavioral trait exports to control signal, wherein and control signal includes that drinking water controls photocontrol visible with multi-mode,
To sum up, the key step of the embodiment of the present invention are as follows: set by configuring visible frequency, modulation system and frequent flashing control
It is standby, multi-mode visible light source is initialized, after initialization, multi-mode visible light source launches visible light signal,
Mouse lives or tests in the rhythm and pace of moving things environment that multi-mode visible light source controls, it is believed that mouse receives multi-mode visible light
Light source is as input, so that the nerve of mouse, the rhythm and pace of moving things, protein expression, brain electricity etc. occur under the radiation of multi-mode visible light source
Variation generates mouse behavior as output, is acquired by mouse behavior acquisition module to mouse behavior and artificial intelligence is real
When analysis handle, processing result is transferred to experimental paradigm control module, experimental paradigm control module passes through according to scientific research personnel
It programs customized experimental paradigm and determines a need for the stimulation for carrying out food and water to mouse automatically, if necessary to just driving thorn
Swash control unit, automatically generate stimulation, continues the behavior for observing mouse later, the behavior of mouse is analyzed, realizes nobody
The closed-loop experiment of work interference.
It studies under the visible light stimulus of multi-mode (various combination of frequency, stroboscopic and modulation system), mice behavior feature
Difference and relevant cranial nerve feedback influence.User has provided particular community by experimental paradigm control module any combination
Visible light and mouse behavior Feedback Rule, the influence that can regulate and control, such as calm nerves, egg are carried out to the cranial nerve maincenter of mouse
White expression selection, EEG signals selection, promote blood circulation with brain area damage/reminiscence etc..
The embodiment of the present invention can solve existing mice behavior experimental technique or the single problem of apparatus function, can be with
Solve the problems, such as that existing mice behavior experiment can not effectively exclude Human disturbance, when can solve scientific research personnel can not define long
Between mouse independence multi-mode test the problem of, can solve existing mice behavior experimental technique or device can not adjust section in real time
The problem of rule control.
Below by a specific embodiment being carried out in detail based on multi-mode visible light mouse intelligent experiment method to invention
It describes in detail bright.
(common mouse circadian rhythm is 24 hours, common sun so that a mouse circadian rhythm is in 50Hz regulation experiment as an example
Light includes the spectral characteristic of different frequency, without artificial modulation system；The purpose for carrying out this experiment is an attempt to mouse round the clock
The rhythm and pace of moving things is adjusted to 22 hours, and whether observation mouse behavior has anxiety and the reaction of other emergency, after experiment, can be carried out mouse
Eeg signal acquisition or analysis of protein observe the variation of its Biochemical Mechanism and nerve signal；Concern 50Hz is because of frequency thus
Brain electricity may with treatment alzheimer's disease have relationship), the specific steps are as follows:
(1) researcher is programmed experimental paradigm control module by interface, defines LED control unit and generates 50Hz
Multi-mode visible light signal (containing intensity, frequency, modulating mode etc.).
(2) researcher is programmed experimental paradigm control module by interface, defines LED control unit Time
Vector is 22 hour period, is set as the rhythm and pace of moving things that experiment needs.
(3) researcher is programmed experimental paradigm control module by interface, and definition feeds the rhythm and pace of moving things of module automatically
It is 22 hours.
(4) researcher is programmed experimental paradigm control module by interface, and definition is met an urgent need by experiment mice
The experimental paradigm pacified is fed automatically to by experiment mice progress when sexual behaviour.
(5) by the sample result of experiment, input database is saved, and it is as shown in Table 1 and Table 2 to save form.Wherein,
Table 1 is that visible light dominant vector data save format, and table 2 is to save format by experiment mice behavior outcome data.
Table 1
| UserID | LED codec | LED Freq | LEDQ | TimeVector |
In table 1, UserID indicates that LED codec indicates the modulation system of this visible light by the title of experiment mice,
LED Freq indicates the working frequency of this visible light, and LEDQ indicates the visual intensity of this time experiment, and TimeVector is indicated
This time time of experiment LED output.UserID occupies two bytes；LED codec occupies two bytes；LED Freq occupies two
A byte；LED Q occupies two bytes；TimeVector be multi-mode visible light adjust event a variable length multidimensional to
Amount.
Table 2
| UserID | Action code | Action Video | Action Control | TimeVector |
In table 2, UserID is indicated by the title of experiment mice, and Action code indicates that the definition code of this event (can be by
Scientific research personnel freely defines, and such as static 00, movement 01 of walking unhurriedly, sniff 02 rapidly moves 03, new line 04 etc.), Action Video
It is directed to the link of associated video record, is directed toward one section of video file comprising time tag, this occurs for this document record mouse
Video clip when movement, Action Control indicate that the processing method for mouse behavior (can freely be determined by scientific research personnel
Justice throws water 01 such as feeding 00, changes multi-mode visible light environment 02 etc.), TimeVector indicates this time experiment Action event
The time of generation.UserID occupies two bytes；Action code occupies two bytes；Action viedo is a link；
Action Control occupies two bytes；TimeVector be behavior occur and handle event a variable length multidimensional to
Amount.
It is proposed according to embodiments of the present invention based on multi-mode visible light mouse intelligent experiment method, tested by stimulation
The different Behavioral features that mouse generates under the influence of multi-mode visible light are realized by experiment mice not with automation stimulating course
It is operated manually the long period of experiments of interference, reaches stimulation by experiment mice nerve, influence rhythm and pace of moving things regulation, protein expression, stimulation
The purpose of kinesitherapy nerve and brain area Memory control.
System is intelligently tested based on multi-mode visible light mouse referring next to what attached drawing description proposed according to embodiments of the present invention
System.
Fig. 3 is the structural representation based on multi-mode visible light mouse intelligence experimental system according to one embodiment of the invention
Figure.
As shown in figure 3, should based on multi-mode visible light mouse intelligence experimental system 10 include: visible light source module 100,
Generation module 200 and automatic control module 300.
Wherein, it is seen that radiant module 100 for configuring multi-mode visible light source, and to multi-mode visible light source into
Row initialization.Generation module 200 is used to control multi-mode visible light source to the visible light signal of mouse transmitting different mode, and
Record the behavioural information of mouse mouse under the visible light signal of different mode.Automatic control module 300 is used for the row to mouse
It is analyzed and processed to obtain the current behavior characteristic of mouse for information, according to current behavior characteristic and predefined experimental paradigm pair
Mouse carries out automatic drinking water stimulation and automatic feedback stimulation.The intelligence experimental system 10 is by stimulation by experiment mice in multi-mode
The different Behavioral features generated under the influence of visible light, realized with automation stimulating course be not operated manually by experiment mice it is dry
The long period of experiments disturbed.
Further, in one embodiment of the invention, the visible light signal of different mode includes: different frequency, no
With the visible light signal of stroboscopic and different modulating characteristic.
Further, in one embodiment of the invention, the row of mouse is acquired from different perspectives by multiple cameras
It for information and is stored, the behavioural information of collected mouse is carried out at analysis automatically by artificial intelligence analysis's software
Reason.
Further, in one embodiment of the invention, being analyzed and processed to the behavioural information of mouse includes: 3D weight
Structure, mouse skeleton extract, motion state assessment.
Further, in one embodiment of the invention, predefined experimental paradigm can be carried out by programming interface
Change.
It should be noted that aforementioned to the explanation based on multi-mode visible light mouse intelligent experiment method embodiment
Suitable for the device of the embodiment, details are not described herein again.
It is proposed according to embodiments of the present invention based on multi-mode visible light mouse intelligence experimental system, it is visible by multi-mode
Light is on the control of the mouse rhythm and pace of moving things and nervous system and influence, by built-in food stimulus control module, realizes that mouse is thrown automatically
It feeds and stimulation, the influence that reduction manual operation tests mice behavior passes through the mouse behavior acquisition module (camera at top
With artificial intelligence analysis's software), mouse current behavior characteristic is obtained, according to the rule that experimental paradigm control module defines, control
Food stimulus control module carries out automatic feedback stimulation to mouse behavior.
In addition, term " first ", " second " are used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance
Or implicitly indicate the quantity of indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or
Implicitly include at least one this feature.In the description of the present invention, the meaning of " plurality " is at least two, such as two, three
It is a etc., unless otherwise specifically defined.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example
Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not
It must be directed to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be in office
It can be combined in any suitable manner in one or more embodiment or examples.In addition, without conflicting with each other, the skill of this field
Art personnel can tie the feature of different embodiments or examples described in this specification and different embodiments or examples
It closes and combines.
Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example
Property, it is not considered as limiting the invention, those skilled in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, modifies, replacement and variant.
Claims (10)
1. one kind is based on multi-mode visible light mouse intelligent experiment method, which comprises the following steps:
Multi-mode visible light source is configured, and the multi-mode visible light source is initialized；
The multi-mode visible light source is controlled to the visible light signal of mouse transmitting different mode, and records the mouse in institute
State the behavioural information of the mouse under the visible light signal of different mode；
The behavioural information of the mouse is analyzed and processed to obtain the current behavior characteristic of the mouse, according to the current line
Carrying out automatic drinking water stimulation and automatic feedback to the mouse for characteristic and predefined experimental paradigm stimulates.
2. according to claim 1 be based on multi-mode visible light mouse intelligent experiment method, which is characterized in that the difference
The visible light signal of mode includes: different frequency, the visible light signal of different stroboscopics and different modulating characteristic.
3. according to claim 1 be based on multi-mode visible light mouse intelligent experiment method, which is characterized in that by multiple
Camera acquires the behavioural information of the mouse from different perspectives and is stored, by artificial intelligence analysis's software automatically to adopting
The behavioural information of the mouse collected is analyzed and processed.
4. according to claim 3 be based on multi-mode visible light mouse intelligent experiment method, which is characterized in that described small
It includes: 3D reconstruct, mouse skeleton extract, motion state assessment that the behavioural information of mouse, which is analyzed and processed,.
5. according to claim 1 be based on multi-mode visible light mouse intelligent experiment method, which is characterized in that described predetermined
The experimental paradigm of justice can be modified by programming interface.
6. one kind is based on multi-mode visible light mouse intelligence experimental system characterized by comprising
Visible light source module for configuring multi-mode visible light source, and carries out the multi-mode visible light source initial
Change；
Generation module for controlling the multi-mode visible light source to the visible light signal of mouse transmitting different mode, and is remembered
Record the behavioural information of mouse mouse under the visible light signal of the different mode；
Automatic control module, the current behavior for being analyzed and processed to obtain the mouse for the behavioural information to the mouse are special
Property, automatic drinking water stimulation and automatic feedback are carried out to the mouse according to the current behavior characteristic and predefined experimental paradigm
Stimulation.
7. according to claim 6 be based on multi-mode visible light mouse intelligence experimental system, which is characterized in that the difference
The visible light signal of mode includes: different frequency, the visible light signal of different stroboscopics and different modulating characteristic.
8. according to claim 6 be based on multi-mode visible light mouse intelligence experimental system, which is characterized in that by multiple
Camera acquires the video information of the behavioural information of the mouse from different perspectives and is stored, soft by artificial intelligence analysis
Part is automatically analyzed and processed the behavioural information of the collected mouse.
9. according to claim 8 be based on multi-mode visible light mouse intelligence experimental system, which is characterized in that described small
It includes: 3D reconstruct, mouse skeleton extract, motion state assessment that the behavioural information of mouse, which is analyzed and processed,.
10. according to claim 6 be based on multi-mode visible light mouse intelligence experimental system, which is characterized in that described pre-
The experimental paradigm of definition can be modified by programming interface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811563626.8A CN109662039A (en) | 2018-12-20 | 2018-12-20 | Based on multi-mode visible light mouse intelligent experiment method and system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811563626.8A CN109662039A (en) | 2018-12-20 | 2018-12-20 | Based on multi-mode visible light mouse intelligent experiment method and system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109662039A true CN109662039A (en) | 2019-04-23 |
Family
ID=66144530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811563626.8A Pending CN109662039A (en) | 2018-12-20 | 2018-12-20 | Based on multi-mode visible light mouse intelligent experiment method and system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109662039A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1062280A (en) * | 1991-11-02 | 1992-07-01 | 北京大学 | Micro-processor controlled multirow is a case |
| CN103026973A (en) * | 2012-11-30 | 2013-04-10 | 中国航天员科研训练中心 | Device for detecting, analyzing and processing reward operation condition reflection in real time |
| CN204336891U (en) * | 2014-12-04 | 2015-05-20 | 清华大学 | A kind of automatic optical processing of toy and behavioristics's checkout gear |
| CN104823872A (en) * | 2014-01-27 | 2015-08-12 | 中国科学院生物物理研究所 | Animal stimulation method |
-
2018
- 2018-12-20 CN CN201811563626.8A patent/CN109662039A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1062280A (en) * | 1991-11-02 | 1992-07-01 | 北京大学 | Micro-processor controlled multirow is a case |
| CN103026973A (en) * | 2012-11-30 | 2013-04-10 | 中国航天员科研训练中心 | Device for detecting, analyzing and processing reward operation condition reflection in real time |
| CN104823872A (en) * | 2014-01-27 | 2015-08-12 | 中国科学院生物物理研究所 | Animal stimulation method |
| CN204336891U (en) * | 2014-12-04 | 2015-05-20 | 清华大学 | A kind of automatic optical processing of toy and behavioristics's checkout gear |
Non-Patent Citations (1)
| Title |
|---|
| 赵邦云等: ""微机控制的大鼠四路穿梭箱主动回避反应实验系统"", 《中国临床康复》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107596533B (en) | System and method for regulating and controlling healthy light environment | |
| CN107660035B (en) | Workplace healthy light environment regulation and control method and system with shift adaptability | |
| CN104871160A (en) | Systems and methods for sensory and cognitive profiling | |
| Lahvis | Unbridle biomedical research from the laboratory cage | |
| CN108717873A (en) | A kind of space luminous environment AI regulating systems based on unsupervised learning technology | |
| Matchette et al. | Dappled light disrupts prey detection by masking movement | |
| Stahlman et al. | There is room for conditioning in the creative process: Associative learning and the control of behavioral variability | |
| CN109662039A (en) | Based on multi-mode visible light mouse intelligent experiment method and system | |
| WO2022262704A1 (en) | Lighting system establishing multispectral rhythm lighting scenario-psychological stress index relationship database, and method | |
| Zhang et al. | Track-Control, an automatic video-based real-time closed-loop behavioral control toolbox | |
| José Paixão et al. | Broiler behavior differs from males to females when under different light wavelengths | |
| US20230380038A1 (en) | Intelligent human centric lighting system with ambient light monitoring of lighting site environment | |
| WO2022242246A1 (en) | Editing method for dynamic spectrum program | |
| Zeldovich | The Doctor Will Sniff You Now | |
| CN117193522A (en) | Brain-computer interaction platform based on weightlessness space research | |
| Imamizu | Changes in Human Brain Networks and Spontaneous Activity Caused by Motor and Cognitive Learning | |
| Kim et al. | Place cell map genesis via competitive learning and conjunctive coding in the dentate gyrus | |
| Hill et al. | An evaluation of emotions induced by biophilic lighting colours using EEG and qualitative methods to support community well-being in urban spaces | |
| Riberto | When and why two emotional experiences are similar to each other | |
| JP2021176137A (en) | Lighting control device, lighting control system, program, and lighting control method | |
| Bonato et al. | Neural coding: Looking up and down the visual thalamus | |
| Falahian et al. | Novel insight into modeling of brain response to flicker light | |
| Johnson et al. | The Working Brain |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190423 |