CN109646574A - A kind of Chinese medicine composition and preparation method thereof and Chinese materia medica preparation promoting postpartum recovery - Google Patents
A kind of Chinese medicine composition and preparation method thereof and Chinese materia medica preparation promoting postpartum recovery Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The present invention provides Chinese medicine composition of a kind of promotion postpartum recovery and preparation method thereof and Chinese materia medica preparation, is related to technical field of traditional Chinese medicines.It include following components according to parts by weight: 15~25 parts of Chinese yam, 15~25 parts of Radix Codonopsis, 10~20 parts of Honeysuckle flower, 10~20 parts of Radix Astragali, 10~20 parts of Rehmannia glutinosa, 10~20 parts of Fructus Forsythiae, 10~20 parts of Radix Angelicae Sinensis, 10~20 parts of rhizoma polygonati, 10~20 parts of the root of Dahurain angelica, 10~20 parts of Radix Paeoniae Alba, 7~15 parts of Radix Glycyrrhizae.The Chinese medicine composition of the promotion postpartum recovery has effects that blood-enrich, dispelling wind and eliminating dampness, detumescence toxin expelling, the control infection of effective inhibitor for the postpartum qi-blood deficiency palpitaition for causing to occur, dyscoimesis, the patient that urination is uncoordinated, milk amount is few.And curative effect is rapid, cheap.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to it is a kind of promote postpartum recovery Chinese medicine composition and its preparation side
Method and Chinese materia medica preparation.
Background technique
Postpartum weakness refers to a kind of inferior health or the morbid state in women postpartum.Due in birth process energy consumption,
Wound and bleeding cause its vigour to be consumed, insufficiency of vital energy and blood, referred to as postpartum weakness.Disease is such as: cold, fear of wind, cold perspiration, waist and knee acid
Soft, cold and pain in the lower abdomen, shortness of breath and palpitation, limbs fatigue, Hypomenorrhea, color are black, and leukorrhea is more, menstrual period edema, dim complexion, long spot, ovum
The symptoms such as nest hypofunction, postpartum frigidity.Puerpera's ferritic is weak, excessive blood loss, thin fluid injury, and the deficiency of blood is appointed in empty sun bloom, punching,
Vessels of the uterus dystrophy, postpartum internal organs wound is dynamic, and hundred sections are hollow, and space between skin and muscles is not firm, instability of surface, and regimen is careless slightly can to occur various postpartum
Disease.Latter half of gestation, estrogen, progesterone, cortin, thyroxine can all increase in various degree in pregnant woman's body, in gestation
During childbirth, internal endocrinal environment was had occurred in variation sharply, especially 24 hours postpartum, hormone in vivo level
Dramatic decrease in short-term, causes the imbalance of organism endocrine, to generate postpartum puerperal fever and postpartum weakness.
Many women take bazhen decoction postpartum to promote Recovery now, and bazhen decoction is by Sijunzi Tang and Siwu Tang group
It closes, i.e. ginseng, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Glycyrrhizae, Radix Angelicae Sinensis, Rehmannia glutinosa, Chinese herbaceous peony and Rhizoma Chuanxiong.Bazhen decoction energy invigorating qi and benefiting blood, can help
Postpartum uterus is restored, but is taken immediately after being not suitable for production, is usually taken when lochia is clean, and bazhen decoction includes people
Ginseng, cost is more expensive, constrains the crowd of taking.
In addition, puerpera's postpartum genital tract row lochia, dirty secretion and perineal wound, to prevent from infecting and reduce antibiotic
Application, be conducive to breast-feeding and supplementary reproduction road row lochia dirt secretion, adjust postpartum it is qi-blood deficiency when, Ying Haiyao
Prevent postpartum reproductive tract infection, to preferably promote Recovery.The patent of invention of application number CN201611131339.0 is public
A kind of postpartum reparation Chinese medicine composition has been opened, puerperal exposure to wind consumptive disease damage can be treated, four limbs are thin and weak, mind dysphoria, and few deficiency of food is slept etc.
Symptom accelerates the reparation of postpartum female body, but controls infection aspect without detumescence toxin expelling, prevention lochiorrhea, inhibitor
Curative effect, therefore, study one kind can adjust postpartum it is qi-blood deficiency when, moreover it is possible to prevent postpartum reproductive tract infection, and curative effect rapidly,
The Chinese medicine composition of cheap promotion postpartum recovery has great importance.
Summary of the invention
Goal of the invention of the invention first is that, in view of the above-mentioned problems, provide it is a kind of promote postpartum recovery Chinese traditional medicine composition
Object for the postpartum qi-blood deficiency palpitaition for causing to occur, dyscoimesis, the patient that urination is uncoordinated, milk amount is few there is QI invigorating to mend
The effect of blood, dispelling wind and eliminating dampness, detumescence toxin expelling, control infection of effective inhibitor.And curative effect is rapid, cheap.
In order to achieve the above objectives, the technical scheme adopted by the invention is that:
A kind of Chinese medicine composition promoting postpartum recovery, includes following components according to parts by weight:
15~25 parts of Chinese yam, 15~25 parts of Radix Codonopsis, 10~20 parts of Honeysuckle flower, 10~20 parts of Radix Astragali, 10~20 parts of Rehmannia glutinosa,
10~20 parts of Fructus Forsythiae, 10~20 parts of Radix Angelicae Sinensis, 10~20 parts of rhizoma polygonati, 10~20 parts of the root of Dahurain angelica, 10~20 parts of Radix Paeoniae Alba, 7~15 parts of Radix Glycyrrhizae.
Preferably, include following components according to parts by weight: 20 parts of Chinese yam, 20 parts of Radix Codonopsis, 15 parts of Honeysuckle flower, 15 parts of Radix Astragali,
15 parts of Rehmannia glutinosa, 15 parts of Fructus Forsythiae, 15 parts of Radix Angelicae Sinensis, 15 parts of rhizoma polygonati, 15 parts of the root of Dahurain angelica, 15 parts of Radix Paeoniae Alba, 9 parts of Radix Glycyrrhizae.
A kind of preparation method for the Chinese medicine composition promoting postpartum recovery, comprising the following steps:
S1, weighed respectively according to the parts by weight Chinese yam, Radix Codonopsis, Honeysuckle flower, Radix Astragali, Rehmannia glutinosa, Fructus Forsythiae, Radix Angelicae Sinensis, rhizoma polygonati,
The root of Dahurain angelica, Radix Paeoniae Alba and Radix Glycyrrhizae simultaneously crush, mix, and are added in 60~90% ethyl alcohol that pH value is 1.5~2.5, add in 40~60 DEG C
It is filtered after 0.5~1.5h of thermal extraction, obtains filtrate I and filter residue I.
S2, filter residue I is added in 60~90% ethyl alcohol that pH value is 6.5~7.0, in 40~60 DEG C of heating extractions 0.5
It is filtered after~1.5h, obtains filtrate II and filter residue II.
S3, filter residue II is added in 60~90% ethyl alcohol that pH value is 7.8~8.5, in 40~60 DEG C of heating extractions 0.5
It is filtered after~1.5h, obtains filtrate II I, discard filter residue；Mixed filtrate I, filtrate II and filtrate II I recycle ethyl alcohol, obtain described
Chinese medicine composition.
Preferably, in described step S1, S2 and S3, the bath raio of 60~90% ethyl alcohol and the filter residue is 1:1~3.
Preferably, in step S3, the thick paste that relative density is 1.30~1.35 is condensed into 60 DEG C after recycling ethyl alcohol.
Another goal of the invention of the invention is, in view of the above-mentioned problems, providing a kind of Chinese materia medica preparation for promoting postpartum recovery, energy
Enough medication demands for preferably meeting patient.
In order to achieve the above objectives, the technical scheme adopted by the invention is that:
A kind of Chinese materia medica preparation promoting postpartum recovery, including the Chinese medicine composition for promoting postpartum recovery and pharmaceutically
Acceptable auxiliary material.
Preferably, the Chinese materia medica preparation is oral solution, electuary, tablet, capsule or granule.
Due to the adoption of the above technical scheme, the invention has the following advantages:
1. Chinese medicine composition of the invention is not assisted for the postpartum qi-blood deficiency palpitaition for leading to appearance, dyscoimesis, urination
It adjusts, the patient that milk amount is few, has effects that blood-enrich, dispelling wind and eliminating dampness, detumescence toxin expelling, the control infection of effective inhibitor.And it treats
It imitates rapid, cheap.
The Chinese medicine composition is guidance with theory of traditional Chinese medical science, in line with the principle of " searching for the primary cause of disease in treatment ", by the interior principle phase controlled and controlled outside
Mutually perforation, the unification of realization theory and practice.Selected according to the compatibility logic of Chinese medicine monarch, in the party Radix Astragali, Rehmannia glutinosa,
Honeysuckle flower and the root of Dahurain angelica are monarch drug in a prescription, invigorating qi for strengthening superficies, enrich blood moist, clearing heat and detoxicating, dispelling wind and eliminating dampness, detumescence and apocenosis；It can promote postpartum
Rehabilitation, and lochiorrhea, inhibitor control infection can be prevented；Rhizoma polygonati, Fructus Forsythiae, Radix Angelicae Sinensis and white peony root is used as ministerial are selected, invigorates the spleen and benefits qi, grow
High and level tone liver is held back by kidney replenishing essence, clearing heat and detoxicating, dispersing swelling and dissipating binds, blood-nourishing and battalion, facilitates monarch drug in a prescription blood-enrich, detumescence toxin expelling.Chinese yam and
Radix Codonopsis is adjutant, and strengthening the spleen and tonifying the lung is reinforced the kidney, strengthening the essence, adjusts stomach weakness, improves puerpera's resistance, promotes to restore.Radix Glycyrrhizae is to make medicine,
Invigorating middle warmer and replenishing QI, purging fire for removing toxin, and coordinating the drug actions of a prescription.
The effect of primary raw material medicine and effect are as follows:
Chinese yam: sweet in flavor；It is mild-natured.Function: tonifying spleen supports lung, reinforces the kidney, strengthening the essence；Main splenasthenic diarrhea；Deficiency of food edema；Deficiency syndrome of the lung cough and asthma；
It quenches one's thirst；Spermatorrhea；Leukorrhagia；Kidney deficiency frequent micturition.
Radix Codonopsis: sweet in flavor；It is mild-natured.Function: strengthening the spleen and tonifying the lung, nourishing generate fluid.Main weakness of the spleen and the stomach, anorexia and loose stool, limbs fatigue, lung
Void is breathed with cough, shortness of breath and spontaneous perspiration, gas micro- two lose.
Honeysuckle flower: sweet in flavor；It is cold in nature.Function: clearing heat and detoxicating, wind-heat dissipating.
Radix Astragali: sweet in flavor；It is warm-natured.Function: invigorating qi for strengthening superficies, detoxification apocenosis, diuresis, myogenic.
Rehmannia glutinosa: sweet in flavor；It is warm-natured.Function: enrich blood moist；Beneficial to spirit and marrow.Main blood tiger is sallow, dizziness palpitaition；Irregular menstruation；
It collapses more than；The deficiency of liver-yin and kidney-yin；Hectic fever night sweat；Spermatorrhea impotence；It is infertile；Soreness and weakness of waist and knees；Hiccough and deaf；It is dim-sighted；Beard and hair is early
It is white；It quenches one's thirst；Constipation；Kidney deficiency characterized by dyspnea.
Fructus Forsythiae: bitter；Cold nature.Function: clearing heat and detoxicating；Dispersing swelling and dissipating binds；Anemopyretic cold.Main anemopyretic cold；Warm disease；Heat gonorrhea
Renal shutdown；Ulcer；Pyogenic infections.
Radix Angelicae Sinensis: sweet in flavor；It is warm-natured.Function: it enriches blood；Promoting blood circulation；Menstruction regulating and pain relieving；Moisturizing dryness and lubricating intestine.The main deficiency of blood；Irregular menstruation；Amenorrhoea；
Dysmenorrhea；Metrorrhagia and metrostaxis；Asthenia cold abdominalgia；Numbness；Intestines are dry and shit is difficult.
Rhizoma polygonati: sweet in flavor；It is mild-natured.Function: Yin nourishing and lung moistening；It invigorates the spleen and benefits qi；Zishen fill fine.Main deficiency of Yin phthisical cough；Xeropulmonary cough；Spleen
It is empty out of strength；Deficiency of food and dry mouth；It quenches one's thirst；Tinnitus mesh is dark；Poliosis.
The root of Dahurain angelica: acrid flavour；It is warm-natured.Function: dispelling wind and eliminating dampness；Logical steal relieves pain；Detumescence and apocenosis.Main cold headache；Pain in the supra-orbital bone；Tooth
Bitterly；Nasal obstruction；Nasosinusitis；Wet victory chronic diarrhea；Women leukorrhea；Ulcer sore is die young；Venomous snake bite.
Radix Paeoniae Alba: bitter；Acid；Cold nature.Function: blood-nourishing and battalion；Relieving spasm to stop pain；Hold back high and level tone liver.Main irregular menstruation；It passes through abdomen
Bitterly；Metrorrhagia and metrostaxis；Spontaneous perspiration；Night sweat；Four limbs contraction pain；Headache；Dizziness.
Radix Glycyrrhizae: sweet in flavor；It is mild-natured.Function: invigorating middle warmer and replenishing QI；Relieving spasm to stop pain；Moistening lung to arrest cough；Purging fire for removing toxin；Coordinating the drug actions of a prescription.Master is tired
Idle deficiency of food；Emaciation with sallow complexion；Shortness of breath and palpitation；Abdominal pain loose stool；Four limbs contraction；It is dirty dry；Cough and asthma；Abscess of throat；Ulcerative carbuncle is swollen
Bitterly；Infant fetal toxin；And drug, food poisoning.
2. Chinese medicine composition of the invention, cost of material is low, is free of valuable ingredient of traditional Chinese medicine, and have good efficacy, is suitable for masses
It uses.
3. the preparation method of Chinese medicine composition of the invention is to imitate oral drugs to propose in the transport process of gastrointestinal tract
A kind of traditional Chinese medicine extraction new technology, use the acid alcohol system of selected pH value and alkaline system successively continuously to extract, purpose
Be extract it is high " active mixture " containing index components, can give full play in this way mix ingredients comprehensive function feature and
Be conducive to control the quality of the pharmaceutical preparations with monomer component, finally obtain the effective component of suitable absorption of human body.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Embodiment 1
A kind of Chinese medicine composition promoting postpartum recovery, includes following components according to parts by weight:
It include following components according to parts by weight: 20 parts of Chinese yam, 20 parts of Radix Codonopsis, 15 parts of Honeysuckle flower, 15 parts of Radix Astragali, Rehmannia glutinosa 15
Part, 15 parts of Fructus Forsythiae, 15 parts of Radix Angelicae Sinensis, 15 parts of rhizoma polygonati, 15 parts of the root of Dahurain angelica, 15 parts of Radix Paeoniae Alba, 9 parts of Radix Glycyrrhizae.
Preparation method, comprising the following steps:
S1, weighed respectively according to the parts by weight Chinese yam, Radix Codonopsis, Honeysuckle flower, Radix Astragali, Rehmannia glutinosa, Fructus Forsythiae, Radix Angelicae Sinensis, rhizoma polygonati,
The root of Dahurain angelica, Radix Paeoniae Alba and Radix Glycyrrhizae simultaneously crush, mix, and are added in 80% ethyl alcohol that pH value is 2, bath raio 1:2, in 50 DEG C of heating extractions
It is filtered after 1h, obtains filtrate I and filter residue I.
S2, filter residue I is added in 60~90% ethyl alcohol that pH value is 6.5~7.0, bath raio 1:2 is mentioned in 50 DEG C of heating
It is filtered after taking 1h, obtains filtrate II and filter residue II.
S3, filter residue II is added in 60~90% ethyl alcohol that pH value is 7.8~8.5, bath raio 1:2 is heated in 50 DEG C
It is filtered after extracting 1h, obtains filtrate II I, discard filter residue；Mixed filtrate I, filtrate II and filtrate II I recycle ethyl alcohol, obtain described
Chinese medicine composition.
Embodiment 2
A kind of Chinese medicine composition promoting postpartum recovery, includes following components according to parts by weight:
25 parts of Chinese yam, 25 parts of Radix Codonopsis, 15 parts of Honeysuckle flower, 10 parts of Radix Astragali, 20 parts of Rehmannia glutinosa, 10 parts of Fructus Forsythiae, 10 parts of Radix Angelicae Sinensis, Huang
Smart 20 parts, 10 parts of the root of Dahurain angelica, 16 parts of Radix Paeoniae Alba, 12 parts of Radix Glycyrrhizae.
Preparation method, comprising the following steps:
S1, weighed respectively according to the parts by weight Chinese yam, Radix Codonopsis, Honeysuckle flower, Radix Astragali, Rehmannia glutinosa, Fructus Forsythiae, Radix Angelicae Sinensis, rhizoma polygonati,
The root of Dahurain angelica, Radix Paeoniae Alba and Radix Glycyrrhizae simultaneously crush, mix, and are added in 60% ethyl alcohol that pH value is 1.5, bath raio 1:1 is mentioned in 60 DEG C of heating
It is filtered after taking 0.5h, obtains filtrate I and filter residue I.
S2, filter residue I is added in 60% ethyl alcohol that pH value is 6.5, bath raio 1:1, after 60 DEG C of heating extraction 0.5h
Filtering, obtains filtrate II and filter residue II.
S3, filter residue II is added in 60% ethyl alcohol that pH value is 7.8, bath raio 1:1, after 60 DEG C of heating extraction 1.5h
Filtering, obtains filtrate II I, discards filter residue；Mixed filtrate I, filtrate II and filtrate II I recycle ethyl alcohol, obtain the Chinese traditional medicine composition
Object.
Embodiment 3
A kind of Chinese medicine composition promoting postpartum recovery, includes following components according to parts by weight:
15~25 parts of Chinese yam, 15~25 parts of Radix Codonopsis, 10~20 parts of Honeysuckle flower, 10~20 parts of Radix Astragali, 10~20 parts of Rehmannia glutinosa,
10~20 parts of Fructus Forsythiae, 10~20 parts of Radix Angelicae Sinensis, 10~20 parts of rhizoma polygonati, 10~20 parts of the root of Dahurain angelica, 10~20 parts of Radix Paeoniae Alba, 7~15 parts of Radix Glycyrrhizae.
Preparation method, comprising the following steps:
S1, weighed respectively according to the parts by weight Chinese yam, Radix Codonopsis, Honeysuckle flower, Radix Astragali, Rehmannia glutinosa, Fructus Forsythiae, Radix Angelicae Sinensis, rhizoma polygonati,
The root of Dahurain angelica, Radix Paeoniae Alba and Radix Glycyrrhizae simultaneously crush, mix, and are added in 90% ethyl alcohol that pH value is 2.5, bath raio 1:3 is mentioned in 40 DEG C of heating
It is filtered after taking 0.5h, obtains filtrate I and filter residue I.
S2, filter residue I is added in 90% ethyl alcohol that pH value is 7.0, bath raio 1:3, after 40 DEG C of heating extraction 1.5h
Filtering, obtains filtrate II and filter residue II.
S3, filter residue II is added in 90% ethyl alcohol that pH value is 8.5, bath raio 1:3, after 40 DEG C of heating extraction 0.5h
Filtering, obtains filtrate II I, discards filter residue；Mixed filtrate I, filtrate II and filtrate II I, obtain the Chinese medicine composition.
Embodiment 4
A kind of Chinese materia medica preparation promoting postpartum recovery, the Chinese materia medica preparation are oral solution.
The Chinese materia medica preparation includes the Chinese medicine composition and pharmaceutically acceptable auxiliary material of the promotion postpartum recovery.Institute
The formula that Traditional Chinese medicine composition formula is embodiment 1 is stated, the carrier is water, wherein the Chinese medicine composition accounts for the Chinese medicine system
The 20% of agent quality.
Embodiment 5
A kind of Chinese materia medica preparation promoting postpartum recovery, the Chinese materia medica preparation are electuary.
The Chinese materia medica preparation includes the Chinese medicine composition and pharmaceutically acceptable auxiliary material of the promotion postpartum recovery.Institute
The formula that Traditional Chinese medicine composition formula is embodiment 2 is stated, the carrier is dextrin.Wherein, the Chinese medicine composition accounts for the Chinese medicine
The 30% of the quality of the pharmaceutical preparations.
The Chinese medicine composition is concentrated into the stiff paste that relative density is 1.2, spray drying obtains spray powder；Dextrin is added,
It mixes, particle electuary is made in dry method.
Embodiment 6
A kind of Chinese materia medica preparation promoting postpartum recovery, the Chinese materia medica preparation are capsule.
The Chinese materia medica preparation includes the Chinese medicine composition and pharmaceutically acceptable auxiliary material of the promotion postpartum recovery.Institute
The formula that Traditional Chinese medicine composition formula is embodiment 3 is stated, the carrier is dextrin, capsule and stearic acid.Wherein, the Chinese medicine group
It closes object and accounts for the 15% of the Chinese materia medica preparation quality.
The Chinese medicine composition is concentrated into the stiff paste that relative density is 1.2, auxiliary material is added after being dried under reduced pressure and is granulated, is packed into
To get capsule in capsule shells.
Experimental verification:
1. physical and chemical index detects
Physical and chemical index detection is carried out to the Chinese medicine of Examples 1 to 3 preparation, the results are shown in Table 1.
1 project indicator of table
| Project | Unit | Technical requirements | Inspection result | Determine |
| Lead (in terms of pb) mg/kg | mg/kg | ≤1.5 | 0.05 | It is qualified |
| Arsenic (in terms of As) | mg/kg | ≤1.0 | It is not detected | It is qualified |
| Total mercury (in terms of Hg) | mg/kg | ≤0.3 | It is not detected | It is qualified |
Testing result is shown, in Chinese medicine composition prepared by the present invention, reduces containing for the heavy metals such as lead, total arsenic, total mercury
Amount, has no toxic side effect.
2. long term toxicity test
Chinese materia medica preparation prepared by embodiment 4~6 is subjected to 6 months long term toxicity tests in animal body, gives rat daily
Gastric infusion, dosage are respectively equivalent to 100 times, 50 times, 25 times of adult daily clinical day dose.Observation item includes general
Property observation and the complete detection including hematological examination 29.The result shows that three dosages all do not occur obviously not
Good reaction, it is safe for showing that the Chinese materia medica preparation of 4~6 preparation according to embodiments of the present invention is used for clinical use.
3. clinical effectiveness typical case
Case 1
2018, Cai, female, 31 years old, because of " pregnant 2 produce 1 pregnant 39+4 weeks, scar uterus, the gestation merging infection of the upper respiratory tract "
Row cesarean section, it is postoperative to give embodiment 4 Chinese materia medica preparation one dose per day, it totally three doses, takes orally, 4 days puerperas of cesarean postoperate are general
Situation is good, and no main complaint, body temperature is normal, and bimastism is soft, and in breast amount, lochia is few, and color is light, odorless, and uterus matter is hard, palace bottom U-
3F, blood routine: number of white blood cells 13.78 × 10-9/ L, mean constant of red blood cell 5.10 × 10-12/ L, hemoglobin concentration 121g/L, blood
Platelet number 278 × 10-9/ L, neutrophil leucocyte percentage 80.3%, cent lymphocytes 18.2%, the infection of the upper respiratory tract is not
It aggravates, gives discharge.
Case 2
2018, Mr. Luo, female, 35 years old, because " 1 pregnant 38+2 weeks, obesity, sequelae of pelvic inflammatory disease of pregnant 4 production " row cuts open
Palace produces operation, and pelvic cavity mucous membrane severe is adhered in art, postoperative to give 5 Chinese materia medica preparation of embodiment three times a day, one every time, takes orally,
4 days puerpera's ordinary circumstances of Celiotomy Wean are good, and no main complaint, body temperature is normal, and bimastism is soft, and in breast amount, lochia is few, and color is light, nothing
Stink, uterus matter is hard, palace bottom U-3F, blood routine: number of white blood cells 13.00 × 10-9/ L, mean constant of red blood cell 4.73 × 10-12/ L,
Hemoglobin concentration 118g/L, number of platelets 261 × 10-9/ L, neutrophil leucocyte percentage 72.6%, cent lymphocytes
17.4%, pelvic inflammation does not aggravate, gives discharge.
Case 3
2018, Liang, female, 36 years old, because " pregnant 2 producing 1 pregnant 38+5 weeks, scar uterus, umbilical cord-wrapping, anemia (be admitted to hospital
Blood routine: number of white blood cells 7.42 × 10-9/ L, mean constant of red blood cell 3.73 × 10-12/ L, hemoglobin concentration 106g/L, blood platelet
293 × 10-9/L of number, neutrophil leucocyte percentage 72.9%, hematocrit 32.9%) " row cesarean section, it is postoperative to give reality
It applies 4 Chinese materia medica preparation of example three times a day, one every time, takes orally, 4 days puerpera's ordinary circumstances of cesarean postoperate are good, no main complaint, body
Warm normal, bimastism is soft, and in breast amount, lochia is few, and color is light, odorless, and uterus matter is hard, palace bottom U-3F, blood routine: number of white blood cells
14.67×10-9/ L, mean constant of red blood cell 3.96 × 10-12/ L, hemoglobin concentration 113g/L, Anemia are alleviated, and discharge is given.
In conclusion Chinese medicine composition and its Chinese materia medica preparation of the invention are for the postpartum qi-blood deficiency heart for causing to occur
Throb with fear, dyscoimesis, the patient that urination is uncoordinated, milk amount is few, there is blood-enrich, dispelling wind and eliminating dampness, detumescence toxin expelling, effective inhibitor
The effect of control infection.And curative effect is rapid, cheap.
Above description is the detailed description for the present invention preferably possible embodiments, but embodiment is not limited to this hair
Bright patent claim, it is all the present invention suggested by technical spirit under completed same changes or modifications change, should all belong to
In the covered the scope of the patents of the present invention.
Claims (7)
1. a kind of Chinese medicine composition for promoting postpartum recovery, which is characterized in that according to parts by weight include following components:
15~25 parts of Chinese yam, 15~25 parts of Radix Codonopsis, 10~20 parts of Honeysuckle flower, 10~20 parts of Radix Astragali, 10~20 parts of Rehmannia glutinosa, Fructus Forsythiae
10~20 parts, 10~20 parts of Radix Angelicae Sinensis, 10~20 parts of rhizoma polygonati, 10~20 parts of the root of Dahurain angelica, 10~20 parts of Radix Paeoniae Alba, 7~15 parts of Radix Glycyrrhizae.
2. the Chinese medicine composition according to claim 1 for promoting postpartum recovery, which is characterized in that include according to parts by weight
Following components: 20 parts of Chinese yam, 20 parts of Radix Codonopsis, 15 parts of Honeysuckle flower, 15 parts of Radix Astragali, 15 parts of Rehmannia glutinosa, 15 parts of Fructus Forsythiae, 15 parts of Radix Angelicae Sinensis,
15 parts of rhizoma polygonati, 15 parts of the root of Dahurain angelica, 15 parts of Radix Paeoniae Alba, 9 parts of Radix Glycyrrhizae.
3. promoting the preparation method of the Chinese medicine composition of postpartum recovery according to any claim 1 or 2, feature exists
In, comprising the following steps:
S1, it weighs Chinese yam respectively according to the parts by weight, is Radix Codonopsis, Honeysuckle flower, Radix Astragali, Rehmannia glutinosa, Fructus Forsythiae, Radix Angelicae Sinensis, rhizoma polygonati, white
The root of Dahurian angelica, Radix Paeoniae Alba and Radix Glycyrrhizae simultaneously crush, mix, and are added in 60~90% ethyl alcohol that pH value is 1.5~2.5, heat in 40~60 DEG C
It is filtered after extracting 0.5~1.5h, obtains filtrate I and filter residue I；
S2, filter residue I is added to pH value be 6.5~7.0 60~90% ethyl alcohol in, in 40~60 DEG C of heating extractions 0.5~
It is filtered after 1.5h, obtains filtrate II and filter residue II；
S3, filter residue II is added to pH value be 7.8~8.5 60~90% ethyl alcohol in, in 40~60 DEG C of heating extractions 0.5~
It is filtered after 1.5h, obtains filtrate II I, discard filter residue；Mixed filtrate I, filtrate II and filtrate II I recycle ethyl alcohol, obtain in described
Drug composition.
4. the preparation method of the Chinese medicine composition according to claim 3 for promoting postpartum recovery, which is characterized in that described
Step S1, in S2 and S3, the bath raio of 60~90% ethyl alcohol and the filter residue is 1:1~3.
5. the preparation method of the Chinese medicine composition according to claim 3 for promoting postpartum recovery, which is characterized in that step
In S3, the thick paste that relative density is 1.30~1.35 is condensed into 60 DEG C after recycling ethyl alcohol.
6. a kind of Chinese materia medica preparation for promoting postpartum recovery, which is characterized in that produced including promotion described in any claim 1~2
The Chinese medicine composition of rehabilitation and pharmaceutically acceptable auxiliary material afterwards.
7. the Chinese materia medica preparation according to claim 7 for promoting postpartum recovery, the Chinese materia medica preparation is oral solution, electuary, piece
Agent, capsule or granule.
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| CN113855756A (en) * | 2021-09-22 | 2021-12-31 | 湖南善孝堂健康管理有限责任公司 | Navel-moxibustion traditional Chinese medicine composition with effects of benefiting qi and nourishing blood and preparation method thereof |
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| CN113855756A (en) * | 2021-09-22 | 2021-12-31 | 湖南善孝堂健康管理有限责任公司 | Navel-moxibustion traditional Chinese medicine composition with effects of benefiting qi and nourishing blood and preparation method thereof |
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