CN109641908A - 五元杂环并[3,4-d]哒嗪酮类化合物、其制备方法、药物组合物及其应用 - Google Patents
五元杂环并[3,4-d]哒嗪酮类化合物、其制备方法、药物组合物及其应用 Download PDFInfo
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- CN109641908A CN109641908A CN201780032658.2A CN201780032658A CN109641908A CN 109641908 A CN109641908 A CN 109641908A CN 201780032658 A CN201780032658 A CN 201780032658A CN 109641908 A CN109641908 A CN 109641908A
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- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
本发明提供了一种作为FGFR激酶抑制剂的五元杂环并哒嗪酮类化合物及其制备和应用，具体地，本发明提供了一种如下式(I)所示的化合物；其中，各基团的定义如说明书中所述。本发明的化合物具有很好的FGFR激酶抑制活性，可以用于制备一系列治疗FGFR激酶活性相关的疾病的药物。
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016103530352 | 2016-05-24 | ||
| CN201610353035 | 2016-05-24 | ||
| CN2017100602438 | 2017-01-24 | ||
| CN201710060243.8A CN107417687A (zh) | 2016-05-24 | 2017-01-24 | 五元杂环并[3,4‑d]哒嗪酮类化合物、其制备方法、药物组合物及其应用 |
| PCT/CN2017/085765 WO2017202343A1 (zh) | 2016-05-24 | 2017-05-24 | 五元杂环并[3,4-d]哒嗪酮类化合物、其制备方法、药物组合物及其应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109641908A true CN109641908A (zh) | 2019-04-16 |
| CN109641908B CN109641908B (zh) | 2021-11-19 |
Family
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| CN201710060243.8A Pending CN107417687A (zh) | 2016-05-24 | 2017-01-24 | 五元杂环并[3,4‑d]哒嗪酮类化合物、其制备方法、药物组合物及其应用 |
| CN201780032658.2A Expired - Fee Related CN109641908B (zh) | 2016-05-24 | 2017-05-24 | 五元杂环并[3,4-d]哒嗪酮类化合物、其制备方法、药物组合物及其应用 |
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| CN201710060243.8A Pending CN107417687A (zh) | 2016-05-24 | 2017-01-24 | 五元杂环并[3,4‑d]哒嗪酮类化合物、其制备方法、药物组合物及其应用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20190135818A1 (zh) |
| EP (1) | EP3470415A4 (zh) |
| JP (1) | JP2019519534A (zh) |
| CN (2) | CN107417687A (zh) |
| AU (1) | AU2017269462A1 (zh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107417687A (zh) * | 2016-05-24 | 2017-12-01 | 中国科学院上海药物研究所 | 五元杂环并[3,4‑d]哒嗪酮类化合物、其制备方法、药物组合物及其应用 |
| CN116635371A (zh) * | 2021-02-09 | 2023-08-22 | 苏州阿尔脉生物科技有限公司 | 一种作为sos1抑制剂的多环哒嗪酮类衍生物、其制备方法及用途 |
| CN114957132A (zh) * | 2021-02-20 | 2022-08-30 | 中国科学院上海药物研究所 | 含s构型的氨基苯甲酰胺基哒嗪酮类化合物、其制备方法、药物组合物及应用 |
| CN114225051B (zh) * | 2021-12-16 | 2024-05-10 | 中国人民解放军空军军医大学 | 一种用于治疗银屑病的药物及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016007185A1 (en) * | 2014-07-07 | 2016-01-14 | Eternity Bioscience Inc. | Aminopyridazinone compounds as protein kinase inhibitors |
| WO2016112637A1 (zh) * | 2015-01-14 | 2016-07-21 | 湖北生物医药产业技术研究院有限公司 | Btk抑制剂 |
| CN107417687A (zh) * | 2016-05-24 | 2017-12-01 | 中国科学院上海药物研究所 | 五元杂环并[3,4‑d]哒嗪酮类化合物、其制备方法、药物组合物及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013042137A1 (en) * | 2011-09-19 | 2013-03-28 | Aurigene Discovery Technologies Limited | Bicyclic heterocycles as irak4 inhibitors |
| CA2865021C (en) * | 2012-02-23 | 2020-06-30 | Bayer Intellectual Property Gmbh | Substituted benzothienyl-pyrrolotriazines and uses thereof |
-
2017
- 2017-01-24 CN CN201710060243.8A patent/CN107417687A/zh active Pending
- 2017-05-24 US US16/304,508 patent/US20190135818A1/en not_active Abandoned
- 2017-05-24 EP EP17802189.5A patent/EP3470415A4/en not_active Withdrawn
- 2017-05-24 JP JP2018561990A patent/JP2019519534A/ja active Pending
- 2017-05-24 CN CN201780032658.2A patent/CN109641908B/zh not_active Expired - Fee Related
- 2017-05-24 AU AU2017269462A patent/AU2017269462A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016007185A1 (en) * | 2014-07-07 | 2016-01-14 | Eternity Bioscience Inc. | Aminopyridazinone compounds as protein kinase inhibitors |
| WO2016112637A1 (zh) * | 2015-01-14 | 2016-07-21 | 湖北生物医药产业技术研究院有限公司 | Btk抑制剂 |
| CN107417687A (zh) * | 2016-05-24 | 2017-12-01 | 中国科学院上海药物研究所 | 五元杂环并[3,4‑d]哒嗪酮类化合物、其制备方法、药物组合物及其应用 |
Non-Patent Citations (1)
| Title |
|---|
| YUE YU等: "Facile synthesis of cyanofurans via Michaeladdition/cyclization of ene-yne-ketones with trimethylsilyl cyanide", 《CHEMICAL COMMUNICATIONS (CAMBRIDGE, UNITED KINGDOM)》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20190135818A1 (en) | 2019-05-09 |
| EP3470415A1 (en) | 2019-04-17 |
| CN109641908B (zh) | 2021-11-19 |
| AU2017269462A1 (en) | 2019-01-24 |
| EP3470415A4 (en) | 2019-05-22 |
| JP2019519534A (ja) | 2019-07-11 |
| CN107417687A (zh) | 2017-12-01 |
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