CN109628306A - A kind of cell tensile lesion mimic cell culture apparatus - Google Patents
A kind of cell tensile lesion mimic cell culture apparatus Download PDFInfo
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- CN109628306A CN109628306A CN201910046180.XA CN201910046180A CN109628306A CN 109628306 A CN109628306 A CN 109628306A CN 201910046180 A CN201910046180 A CN 201910046180A CN 109628306 A CN109628306 A CN 109628306A
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- 238000004113 cell culture Methods 0.000 title claims abstract description 20
- 230000003902 lesion Effects 0.000 title claims abstract description 17
- 230000003278 mimic effect Effects 0.000 title claims abstract description 15
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims abstract description 19
- 210000004027 cell Anatomy 0.000 claims description 35
- 210000000663 muscle cell Anatomy 0.000 claims description 6
- 210000004413 cardiac myocyte Anatomy 0.000 claims description 5
- 238000000429 assembly Methods 0.000 claims description 3
- 230000000712 assembly Effects 0.000 claims description 3
- 230000000968 intestinal effect Effects 0.000 claims description 3
- 238000004088 simulation Methods 0.000 claims description 3
- 230000005611 electricity Effects 0.000 claims 1
- 238000012360 testing method Methods 0.000 abstract description 2
- 230000006378 damage Effects 0.000 description 12
- 238000010586 diagram Methods 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 230000034994 death Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 206010061216 Infarction Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000007574 infarction Effects 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 230000009456 molecular mechanism Effects 0.000 description 2
- 210000004165 myocardium Anatomy 0.000 description 2
- 208000004296 neuralgia Diseases 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 208000012661 Dyskinesia Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 108091005975 Myofilaments Proteins 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
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- 238000004090 dissolution Methods 0.000 description 1
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- 239000003344 environmental pollutant Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000003632 microfilament Anatomy 0.000 description 1
- 230000008965 mitochondrial swelling Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000010827 pathological analysis Methods 0.000 description 1
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- 230000008569 process Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
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- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
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- Life Sciences & Earth Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- General Health & Medical Sciences (AREA)
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
A kind of cell tensile lesion mimic cell culture apparatus belongs to medical technical field of test equipment, and in particular to a kind of cell tensile lesion mimic cell culture apparatus.The present invention provides that a kind of structure is simple, continuously adjustable, can imitate cell tensile damaging cells culture apparatus under various scenes.The present invention includes culture pedestal and upper cover, it is characterised in that: the culture the middle of the base is provided with culture tank, and both ends are provided with guide post group in culture tank, and culture tank side is provided with slip clamp corresponding to guide post；Driving motor is provided in the upper cover, driving motor is connected with a rotation briquetting；Connection component is provided between rotation briquetting and slip clamp；The connection component includes two supporters with the cooperation of two slip clamps, and hinged between two supporters, two supporter hinged places are matched with the rotation briquetting.
Description
Technical field
The invention belongs to medical technical field of test equipment, and in particular to a kind of cell tensile lesion mimic cell culture dress
It sets.
Background technique
Daily life and professional sports take exercise in there are various cells to pull, as skeletal muscle is pulled or external force is dampened, enteron aisle
Smooth muscle spasm or stiff property are pulled caused by shrinking, and tensile damage caused by myocardium excess load contraction or hypertrophy or even cardiac muscle are thin
The infarct damage of born of the same parents' tetanic contraction bring, neural (clump, root) cell traction damage.Part muscle cell after generation tensile damage
Or the pathologic processes (also known as delay injuring) such as cell degeneration, death, inflammatory cell infiltration occur for nerve cell.As death is thin
Born of the same parents are more than certain amount, it will impact to body function: patients with mild shows as various heart diseases, dyskinesia, disappears
The symptoms such as change system lesion or mono-anesthesia, neuralgia.It is serious to can behave as heart failure, heart infarction, enteron aisle necrosis, violent neuralgia treating
Bitterly, paralysis or even death etc..
These lesions will be brought if not being subject to early intervention treatment after unusual death occurs for a large amount of stretching damaged cells
The consequence that can not be cured causes the generation of various diseases, seriously threatens the health of people.Clinical and Pathological Analysis as a result, it has been found that
After cell tensile damage, occur myofilament distortion, dissolution, fracture, the morphological changes such as mitochondrial swelling and rupture into the cell.At present
Think that oxygen radical increases and calcium ion disorder is unbalance about cell tensile damage generation theory to participate, but it is specific
Molecular mechanism is still unclear.Occur to further deeply illustrate cell tensile damage in each level such as gene, molecule, cell
Inherent mechanism, and inquire into corresponding injury repair, treatment method, it is necessary to establish under a set of in-vitro simulated various scenes in vivo
Cell tensile damaging cells culture model, to find to stretch caused by various factors and cause to damage to cell by isolated experiment
Detailed molecular mechanism, dead inducement occurs after verifying cell tensile damage, finds prevention or improves Treatment Methods, and propose
Correlation theory theory.
External import cell traction instrument is expensive at present, and has a single function, and is unable to meet demand.The country there are also
Simple analog device, but function is also too simple, cannot simulate true cell tensile damage process in vivo, practicability well
It is not strong.
Summary of the invention
The present invention addresses the above problem, provides that a kind of structure is simple, it is continuously adjustable, can imitate it is thin under various scenes
Born of the same parents' tensile damage cell culture apparatus.
In order to realize that above-mentioned purpose of the invention, the present invention adopt the following technical scheme that, the present invention include culture pedestal and
Upper cover, it is characterised in that: the culture the middle of the base is provided with culture tank, and both ends are provided with guide post group in culture tank, culture
Slot side is provided with slip clamp corresponding to guide post；Driving motor, driving motor and a rotation briquetting are provided in the upper cover
It is connected；Connection component is provided between rotation briquetting and slip clamp；The connection component includes two with the cooperation of two slip clamps
Support body, hinged between two supporters, two supporter hinged places are matched with the rotation briquetting.
As a preferred solution of the present invention, the upper tops are provided with electric-controlled box, are provided in the electric-controlled box
The power supply and control module of driving motor；Electric-controlled box surface, which is provided with, is connected to the control module display module and operation module；
The control module can control the rotating manner of driving motor.
As a preferred solution of the present invention, it is thin to be set as simulation cardiac muscle cell, enteron aisle for the rotation briquetting outer profile
The shrinkage curve of born of the same parents or muscle cell.
Beneficial effects of the present invention: 1, the present invention is by configuring rotation briquetting of various shapes, and cooperates control module tune
The revolving speed of whole driving motor and steering, preferably simulate cardiac muscle cell, the shrinkage curve of intestinal cell and muscle cell (frequency and
Amplitude).
2, due to design feature of the invention, the rotational motion that the present invention can pass out motor is converted into the water of slip clamp
Flat drawing movement, makes the culture membrane between two slip clamps realize being carried out continuously for cell tensile, used in the basic research avoided
Static drawing simulator.More true analogue body inner cell moving scene.
3, the present invention will push China in the treatment level in the field, greatly benefit many patients, generate huge
Social benefit.With important pure science and clinical value.
4, structure is complicated and expensive instrument relative to external by the present invention, has economical and practical, and compact (can be straight
Connect and be put into cell incubator progress follow-up cultivation), materials are easy, and it is easy to operate, it can reuse, be particularly suitable for after high-temperature sterilization
Various preclinical laboratories are carried out in the current Basic Laboratory research in China and clinical department.It is such as promoted, volume production, is had wide
Market prospects.
Detailed description of the invention
Fig. 1 is structural schematic diagram of the invention.
Fig. 2 is the attachment structure schematic diagram of slip clamp and culture pedestal.
Fig. 3 is the side sectional view of Fig. 2.
Fig. 4 is structural schematic diagram when cultivating pedestal installation culture membrane.
Fig. 5 is the structural schematic diagram of upper cover.
Fig. 6~Figure 11 is present invention rotation briquetting outer profile schematic diagram.
1 it is culture pedestal in attached drawing, 2 be outer rim, 3 be fin, 4 be sliding rail, 5 be guide post group, 6 be upper cover, 7 is support
Body, 8 be rotation briquetting, 9 be gear set, 10 be electric-controlled box, 11 be support shaft, 12 be driving motor, 13 be connection component, 14 be
Culture tank, 15 for upper horizontal axis, 16 be hook, 17 be slip clamp, 18 be lower horizontal axis, 19 be guide wheel assemblies, 20 be collapse spring,
21 it is culture membrane, 22 be operation module, 23 is display module.
Specific embodiment
The present invention includes culture pedestal 1 and upper cover 6, it is characterised in that: is provided with culture tank in the middle part of the culture pedestal 1
14, both ends are provided with guide post group 5 in culture tank 14, and 14 side of culture tank is provided with slip clamp 17 corresponding to guide post；It is described
Driving motor 12 is provided in upper cover 6, driving motor 12 is connected with a rotation briquetting 8；It is set between rotation briquetting 8 and slip clamp 17
It is equipped with connection component 13；The connection component 13 includes two supporters 7 with the cooperation of two slip clamps 17, is cut with scissors between two supporters 7
It connects, two supporters, 7 hinged place is matched with the rotation briquetting 8.
As a preferred solution of the present invention, it is provided with electric-controlled box 10 at the top of the upper cover 6, is set in the electric-controlled box 10
It is equipped with the power supply and control module of driving motor 12；10 surface of electric-controlled box, which is provided with, is connected to the control module 23 He of display module
Operation module 22；The control module can control the rotating manner of driving motor 12.
As a preferred solution of the present invention, it is thin to be set as simulation cardiac muscle cell, enteron aisle for 8 outer profile of rotation briquetting
The shrinkage curve of born of the same parents or muscle cell.
The guide post group 5 includes the upper horizontal axis 15 and lower horizontal axis 18 being respectively arranged on 14 both ends inner wall of culture tank.Make
Cell culture film 21(can be pellosil etc. by the used time), upper horizontal axis 15 and lower horizontal axis 18 across 14 both ends of culture tank, and will training
End and the slip clamp 17 for supporting film 21 are fixed, formation can be easy to cultivate the plane of cell between two lower horizontal axis 18.
The side that culture 1 surface of pedestal is located at culture tank 14 is provided with sliding rail 4；17 bottom of slip clamp is provided with
The guide wheel assemblies 19 cooperated with sliding rail 4.
It is provided between the slip clamp 17 and culture pedestal 1 and collapses spring 20；Collapsing spring 20 can provide slip clamp 17
Restoring force, avoid 21 stress of cell culture film excessive.
Hook 16 is provided in the slip clamp 17,7 lower end of supporter of the connection component 13 is matched with hook 16.
The driving motor 12 is connected by gear set 9 with support shaft 11, and support shaft 11 is fixed in upper cover 6；Described turn
Dynamic pressure block 8 is set in support shaft 11.
8 outer profile of rotation briquetting is set as triangle, and a line of triangle is set as two continuous outer convex arcs
Shape；Or, the outer profile of rotation briquetting 8 is set as rectangle, a line of rectangle is set as an outer convex.Above two shape
For simulating cardiac muscle cell.
8 outer profile of rotation briquetting is set as ellipse；Or, the outer profile of rotation briquetting 8 is set as rectangle, rectangle
A line is set as the arc of an indent.Above two shape is for simulating intestinal cell.
8 outer profile of rotation briquetting is set as rectangle, and the top of rectangle is set as the pointed shape of outwardly convex, rectangle
It is set as the pointed shape being recessed inwardly below；Or, rotation 8 outer profile of briquetting is set as regular hexagon, above two shape is used for
Simulate muscle cell.
The outer rim 2 of the culture pedestal 1 is provided with the supporting table of upper cover 6, is provided with fin 3 in supporting table.Pass through fin 3
Cooperate with upper cover 6, both guaranteed that air can enter in the present invention, guarantees the life condition of cell, and pollutant will not be entered, to thin
Born of the same parents pollute.
Then two supporters 7 are stuck at hook 16, then in use, fix culture membrane 21 first by the present invention
Upper cover 6 is changed；During the lid of upper cover 6 is lower, rotation briquetting 8 is contacted with two supporters, 7 hinged place, and two slip clamps 17 are supportted
Open certain distance；After the completion of cell culture, driving motor 12 can be controlled by control module and rotated, rotate briquetting 8 and connection
The stretching repeatedly of culture membrane 21 is realized in the cooperation of component 13.
It is understood that being merely to illustrate the present invention above with respect to specific descriptions of the invention and being not limited to this
Technical solution described in inventive embodiments, those skilled in the art should understand that, still the present invention can be carried out
Modification or equivalent replacement, to reach identical technical effect；As long as meet use needs, all protection scope of the present invention it
It is interior.
Claims (10)
1. a kind of cell tensile lesion mimic cell culture apparatus, including culture pedestal (1) and upper cover (6), it is characterised in that: institute
It states and is provided with culture tank (14) in the middle part of culture pedestal (1), culture tank (14) interior both ends are provided with guide post group (5), culture tank
(14) side is provided with slip clamp (17) corresponding to guide post；Driving motor (12), driving motor are provided in the upper cover (6)
(12) it is connected with rotation briquetting (8)；Connection component (13) are provided between rotation briquetting (8) and slip clamp (17)；The company
Connected components (13) include two supporters (7) with two slip clamps (17) cooperation, hinged, two supporters (7) between two supporters (7)
Hinged place is matched with the rotation briquetting (8).
2. a kind of cell tensile lesion mimic cell culture apparatus according to claim 1, it is characterised in that: the upper cover
(6) top is provided with electric-controlled box (10), and the power supply and control module of driving motor (12) are provided in the electric-controlled box (10)；Electricity
Control box (10) surface, which is provided with, is connected to the control module display module (23) and operation module (22)；The control module can be controlled
The rotating manner of driving motor (12) processed.
3. a kind of cell tensile lesion mimic cell culture apparatus according to claim 1, it is characterised in that: the rotation
Briquetting (8) outer profile is set as the shrinkage curve of simulation cardiac muscle cell, intestinal cell or muscle cell.
4. a kind of cell tensile lesion mimic cell culture apparatus according to claim 1, it is characterised in that: the guiding
Column group (5) includes the upper horizontal axis (15) and lower horizontal axis (18) being respectively arranged on the inner wall of culture tank (14) both ends.
5. a kind of cell tensile lesion mimic cell culture apparatus according to claim 1, it is characterised in that: the culture
The side that pedestal (1) surface is located at culture tank (14) is provided with sliding rail (4)；Slip clamp (17) bottom is provided with and sliding rail
(4) guide wheel assemblies (19) cooperated.
6. a kind of cell tensile lesion mimic cell culture apparatus according to claim 1, it is characterised in that: the sliding
It is provided between folder (17) and culture pedestal (1) and collapses spring (20)；Collapsing spring (20) can provide the reply of slip clamp (17)
Power avoids cell culture film (21) stress excessive.
7. a kind of cell tensile lesion mimic cell culture apparatus according to claim 1, it is characterised in that: the sliding
It is provided with hook (16) on folder (17), supporter (7) lower end of the connection component (13) is matched with hook (16).
8. a kind of cell tensile lesion mimic cell culture apparatus according to claim 2, it is characterised in that: the driving
Motor (12) is connected by gear set (9) with support shaft (11), and support shaft (11) is fixed in upper cover (6)；The rotation briquetting
(8) it is set on support shaft (11).
9. a kind of cell tensile lesion mimic cell culture apparatus according to claim 1, it is characterised in that: the culture
The outer rim (2) of pedestal (1) is provided with the supporting table of upper cover (6), is provided with fin (3) in supporting table.
10. a kind of cell tensile lesion mimic cell culture apparatus according to claim 1, it is characterised in that: described turn
Dynamic pressure block (8) outer profile is set as triangle, and a line of triangle is set as two continuous outer convexes；Or, rotation pressure
The outer profile of block (8) is set as rectangle, and a line of rectangle is set as an outer convex；Or, rotation briquetting (8) foreign steamer
Exterior feature is set as ellipse；Or, the outer profile of rotation briquetting (8) is set as rectangle, a line of rectangle is set as an indent
Arc；Or, rotation briquetting (8) outer profile is set as rectangle, the top of rectangle is set as the pointed shape of outwardly convex, rectangle
Be set as the pointed shape being recessed inwardly below；Or, rotation briquetting (8) outer profile is set as regular hexagon.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910046180.XA CN109628306A (en) | 2019-01-18 | 2019-01-18 | A kind of cell tensile lesion mimic cell culture apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910046180.XA CN109628306A (en) | 2019-01-18 | 2019-01-18 | A kind of cell tensile lesion mimic cell culture apparatus |
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| CN109628306A true CN109628306A (en) | 2019-04-16 |
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| CN201910046180.XA Pending CN109628306A (en) | 2019-01-18 | 2019-01-18 | A kind of cell tensile lesion mimic cell culture apparatus |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110343614A (en) * | 2019-06-10 | 2019-10-18 | 中国科学院深圳先进技术研究院 | A kind of in vitro culture device of stimulating cellular growth |
| CN113462567A (en) * | 2021-07-29 | 2021-10-01 | 中国人民解放军空军军医大学 | Cell culture device for simulating cell deformation damage |
| CN113637581A (en) * | 2021-07-21 | 2021-11-12 | 重庆大学 | Instantaneous stretching of cell and high temperature are loading equipment in coordination |
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| JPH01206989A (en) * | 1988-02-16 | 1989-08-21 | Snow Brand Milk Prod Co Ltd | Cell culture tank |
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| CN202626200U (en) * | 2012-05-21 | 2012-12-26 | 中国医学科学院整形外科医院 | Cell traction culture device |
| CN205241655U (en) * | 2015-11-27 | 2016-05-18 | 中国医科大学附属盛京医院 | Mould device is made in tensile damage of cell |
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| CN207276630U (en) * | 2017-08-16 | 2018-04-27 | 李斌 | Mechanical loading cell culture apparatus |
| CN209685805U (en) * | 2019-01-18 | 2019-11-26 | 中国医科大学附属盛京医院 | A kind of cell tensile lesion mimic cell culture apparatus |
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2019
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| CN205241655U (en) * | 2015-11-27 | 2016-05-18 | 中国医科大学附属盛京医院 | Mould device is made in tensile damage of cell |
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| Title |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110343614A (en) * | 2019-06-10 | 2019-10-18 | 中国科学院深圳先进技术研究院 | A kind of in vitro culture device of stimulating cellular growth |
| CN113637581A (en) * | 2021-07-21 | 2021-11-12 | 重庆大学 | Instantaneous stretching of cell and high temperature are loading equipment in coordination |
| CN113637581B (en) * | 2021-07-21 | 2023-06-02 | 重庆大学 | Instantaneous cell stretching and high-temperature collaborative loading equipment |
| CN113462567A (en) * | 2021-07-29 | 2021-10-01 | 中国人民解放军空军军医大学 | Cell culture device for simulating cell deformation damage |
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