CN109620851A - A kind of antibacterial reparation liquid of acne skin - Google Patents
A kind of antibacterial reparation liquid of acne skin Download PDFInfo
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- CN109620851A CN109620851A CN201910140137.XA CN201910140137A CN109620851A CN 109620851 A CN109620851 A CN 109620851A CN 201910140137 A CN201910140137 A CN 201910140137A CN 109620851 A CN109620851 A CN 109620851A
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- sargassum
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- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 31
- 206010000496 acne Diseases 0.000 title claims abstract description 31
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 22
- 239000007788 liquid Substances 0.000 title claims abstract description 20
- 241000195474 Sargassum Species 0.000 claims abstract description 22
- 239000000243 solution Substances 0.000 claims abstract description 20
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229910052709 silver Inorganic materials 0.000 claims abstract description 17
- 239000004332 silver Substances 0.000 claims abstract description 17
- 239000007864 aqueous solution Substances 0.000 claims abstract description 16
- 239000000178 monomer Substances 0.000 claims abstract description 15
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 14
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 14
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 14
- 238000000605 extraction Methods 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 108090000790 Enzymes Proteins 0.000 claims abstract description 9
- 102000004190 Enzymes Human genes 0.000 claims abstract description 9
- 239000008213 purified water Substances 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 229940088598 enzyme Drugs 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 230000009471 action Effects 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- 230000007062 hydrolysis Effects 0.000 claims description 4
- 238000006460 hydrolysis reaction Methods 0.000 claims description 4
- 108010059892 Cellulase Proteins 0.000 claims description 3
- 108090000526 Papain Proteins 0.000 claims description 3
- 239000004365 Protease Substances 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 3
- 230000000996 additive effect Effects 0.000 claims description 3
- 229940106157 cellulase Drugs 0.000 claims description 3
- 230000007071 enzymatic hydrolysis Effects 0.000 claims description 3
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 claims description 3
- 238000001704 evaporation Methods 0.000 claims description 3
- 230000008020 evaporation Effects 0.000 claims description 3
- 230000000937 inactivator Effects 0.000 claims description 3
- 229940055729 papain Drugs 0.000 claims description 3
- 235000019834 papain Nutrition 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- 239000013049 sediment Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000002525 ultrasonication Methods 0.000 claims description 3
- 235000019441 ethanol Nutrition 0.000 claims 2
- 235000009508 confectionery Nutrition 0.000 claims 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract description 15
- 239000003814 drug Substances 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 7
- 238000002604 ultrasonography Methods 0.000 abstract description 5
- 238000002360 preparation method Methods 0.000 abstract description 4
- 238000005265 energy consumption Methods 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 28
- 238000000034 method Methods 0.000 description 8
- 229940079593 drug Drugs 0.000 description 7
- 150000004676 glycans Chemical class 0.000 description 6
- 229920001282 polysaccharide Polymers 0.000 description 6
- 239000005017 polysaccharide Substances 0.000 description 6
- 230000032683 aging Effects 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 239000011049 pearl Substances 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000004060 metabolic process Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 241001474374 Blennius Species 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- 241000512259 Ascophyllum nodosum Species 0.000 description 2
- 241000195493 Cryptophyta Species 0.000 description 2
- 241000186427 Cutibacterium acnes Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 238000005054 agglomeration Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000003797 essential amino acid Substances 0.000 description 2
- 235000020776 essential amino acid Nutrition 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 210000004209 hair Anatomy 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000035800 maturation Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 235000015816 nutrient absorption Nutrition 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000003961 penetration enhancing agent Substances 0.000 description 2
- 238000000053 physical method Methods 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 229940055019 propionibacterium acne Drugs 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 229940010747 sodium hyaluronate Drugs 0.000 description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 229920001543 Laminarin Polymers 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 206010027146 Melanoderma Diseases 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 241000212297 Pelvetia Species 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 208000000260 Warts Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000003399 chemotactic effect Effects 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 239000003317 industrial substance Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- DBTMGCOVALSLOR-VPNXCSTESA-N laminarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O[C@@H]1[C@@H](O)C(O[C@H]2[C@@H]([C@@H](CO)OC(O)[C@@H]2O)O)O[C@H](CO)[C@H]1O DBTMGCOVALSLOR-VPNXCSTESA-N 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 230000037257 muscle growth Effects 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 201000010153 skin papilloma Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 230000008337 systemic blood flow Effects 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Alternative & Traditional Medicine (AREA)
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Abstract
The present invention relates to biological product technical fields, in particular for the antibacterial preparation for repairing liquid of acne skin, the antibacterial reparation liquid of the acne skin, (volume ratio) is prepared by following raw materials, monomer silver aqueous solution 3-5%, hydrolyzed pearl solution 1-5%, gulfweed extract 20-35%, hyaluronic acid 1-5%, surplus is purified water.Sargassum is natural plants, by ultrasound wave auxiliary enzyme extraction process, reduces Extracting temperature, shortens extraction time, reduces energy consumption, while ultrasonic wave also has certain bactericidal effect, can guarantee that extract liquor is unlikely to deteriorate.The medicine have the advantages that realizing natural environmental-protective theory in raw material and preparation process, implement to be easy, significant effect.
Description
Technical field
The present invention relates to biological product technical fields, prepare in particular for the antibacterial reparation liquid of skin.
Background technique
Adolescent acne is commonly called as whelk, acne, and Chinese medicine ancient times claim face sore, acne.It is a kind of common disease of dermatology, it is more
Morbidity.According to statistics, the Adolescent male for having 95%, the puberty women for having 85% suffered from different degrees of acne, so everybody
It is very proper for being called " whelk ".Acne has a variety of skin lesion forms, including acne, papule, warts, tubercle etc..
The cause of disease of acne is complex, and modern medicine thinks that the pathogenesis of acne is mainly led with hypersteatosis, pilosebaceous follicle
The factors such as blockage, bacterium infection and inflammatory reaction are closely related.Adolesce androgen especially testosterone in descendant's body
Content increases rapidly, and sebaceous glands is promoted to develop and generate a large amount of sebums.The dyskeratosis of leather bag sebaceous gland duct causes to lead simultaneously
Blockage, dyssebacia form horn plug, that is, micro mist thorn.Multiple-microorganism especially propionibacterium acnes are a large amount of in hair follicle
Breeding, the lipase that propionibacterium acnes generate decompose sebum and generate free fatty acid, while chemotactic inflammatory cell and medium, finally
Induce and aggravate inflammatory reaction, acne has the characteristics that the course of disease is long, easy to recur, long-standing problem numerous teenagers.
The method for treating acne has very much, also includes a small number of external drugs mostly based on oral drugs.Oral mode master
Will be using systemic blood circulation come Formulations for systemic administration, to reach the effect for the treatment of acne, the general course for the treatment of is longer, ineffective.External application
Mode multi-pass, which is crossed, smears external drug or cosmetics in disease sites to treat acne, and cosmetic applying can directly make drug
For human body face, so that drug sufficiently with facial contact and quickly penetrates into skin, effectively extend drug and skin contact time,
Skin absorption of drugs degree is improved, treatment cycle is substantially shortened.But in the cosmetics for the treatment of acne currently on the market
Mostly containing chemical components such as mercury, tartaric acid, it be easy to cause the adverse reactions such as skin allergy, injured cutaneous tissue structure, treatment effect
Fruit is unsatisfactory.
Hydrolyzed pearl solution can be applied to daily necessities, in health food, have unique excellent results, make skin health,
It is fine and smooth, moist, smooth, pure white, can more prove effective to aging and coarse skin, can reduce wrinkle, eliminate blackspot, to facial boil,
Whelk, wound etc. fill and lead up, heal, anti-inflammatory, promoting muscle growth functions.The taurine originated in the sea water pearls of Beihai, Guangxi may be used also
To play the role of anti-inflammatory, refresh oneself.
Abounding with the sargassum in the Beihai, Guangxi island Wei Zhou is a kind of seaweed in brown alga, belongs to brown alga mouthful, pelvetia silquosa mesh, horse
Wei Zao section is mostly perennial macro, is mainly grown in low tide with the rock at 2-3 meters of depth of waters of Shi Zhaozhong or subtidal zone
On.Containing abundant dietary fiber, laminaran, minerals and vitamins and good higher unsaturated fatty acid and rationally in sargassum
Essential amino acid composition, wherein the content of essential amino acid is much higher than kelp, seaweed, remaining ingredient and kelp, seaweed are close,
It can be used as the quality raw materials of health food and drug.
In conclusion in order to protect skin, it is necessary to research and develop one kind and use no or little industrial chemicals, be mentioned using pure plant
It takes, the reparation solution for acne skin.
Summary of the invention
The purpose of the present invention is to provide one kind to be used for the antibacterial reparation solution of acne skin, and especially a kind of monomer silver is water-soluble
The water-soluble polymers that liquid, hydrolyzed pearl solution, gulfweed extract, hyaluronic acid, purified water form, have antibacterial reparation skin
Function, while it is more environmentally-friendly, safety, have the longer shelf-life.
To achieve the goals above, this invention takes such technical measures, a kind of antibacterial reparation liquid of acne skin, by
Following raw materials are prepared (volume ratio), monomer silver aqueous solution 3-5%, hydrolyzed pearl solution 1-5%, gulfweed extract 20-35%, transparent
Matter acid 1-5%, surplus are purified water.
The monomer silver refers to that partial size is 10-1000 nanometers of elemental metals silver particles, is prepared by pure physical method,
There are merchandise sales.The monomer silver solution refers to the argentiferous water-soluble solution of argentiferous 500-1000PPM.
Hydrolyzed pearl solution refers to: after removing calcium carbonate in pearl aqueous solution, being rich in for extraction is deposited in the form of polypeptide
Keratoprotein (amino acid) aqueous solution.Document CN104399973A discloses the production method of hydrolyzed pearl solution.
Gulfweed extract: sargassan aqueous solution is extracted using ultrasound wave auxiliary enzyme, sargassan content is in 15-
17%。
Sargassan extraction process: (1) it by the sargassum leaf of picking, cleans, dry；(2) by the horse hair of dried and clean
Algae leaf is ground；(3) powder of sargassum leaf is put into supersonic generator container, ultrasonic wave action time is 30-60 points
Clock, power 350W；(4) 10-20 times of aqueous solution then is added in the powder of the sargassum leaf after ultrasonication, stirring is equal
Even, adjusting PH is 4-6；(5) papain or cellulase 2-3% is added, keeps the temperature 1-3 hours in 50 DEG C of water-baths of water-bath,
Then PH=7.0 are adjusted with sodium hydroxide solution；(6) 0.5 hour inactivator is acted in 90 DEG C of water-baths；(7) 80 DEG C of water-baths 2.5
Hour, it 2000 revs/min, is centrifuged 10 minutes, supernatant water-bath is concentrated by evaporation to 1/4 volume, and 3 times of 95% second of volume are added
Alcohol；(8) alcohol precipitation 12-18 hours, supernatant is abandoned, 3000 revs/min, is centrifuged 10 minutes, sediment is dried in vacuo thick up to sargassum
Polysaccharide.
The optimal processing parameter of ultrasound wave auxiliary enzyme method extraction sargassan are as follows: ultrasonic wave action time is 40 minutes,
Power is 350W, and operating temperature is 80 DEG C, 44.95 DEG C of hydrolysis temperature, enzymatic hydrolysis pH5.0, enzymolysis time 2.05 hours, enzyme additive amount
2.5%.Under the technological parameter, sargassum coarse polysaccharide extractive rate can reach 17%, be better than prior art.
Hyaluronic acid is a kind of multi-functional matrix, and hyaluronic acid (sodium hyaluronate) HA is distributed widely in partes corporis humani position.Wherein
Skin also contains a large amount of hyaluronic acid.The content and metabolism of human skin maturation and ageing process also with hyaluronic acid
And change, it can improve skin-nourishing metabolism, make skin it is tender, it is smooth, go wrinkle, increase elasticity, prevent aging, in moisturizing
It is again simultaneously good skin penetration enhancer.It is used cooperatively with other nutritional ingredients, can play and promote nutrient absorption more
Ideal effect.
The antibacterial reparation liquid of acne skin is rich in the ingredients such as hmw protein, the polysaccharide extracted from pearl, sargassum,
The dispersion protection for strengthening monomer silver, avoids the agglomeration of monomer silver, and protection and money have nourished skin.It is particularly suitable
In the skin care to antibiotic allergic human population.
The antibacterial reparation liquid of acne skin uses the sargassum on the island Beihai, Guangxi Wei Zhou, passes through ultrasonic wave extraction work
Skill reduces Extracting temperature, shortens extraction time, reduces energy consumption, while ultrasonic wave also has certain bactericidal effect, energy
Guarantee that extract liquor is unlikely to deteriorate.In raw material and preparation process, natural environmental-protective theory is realized, present invention process is simple, implements
It is easy, significant effect.
For the present invention will be described in detail, the present invention is described in further detail below with reference to embodiment.
Specific embodiment
Embodiment 1
A kind of antibacterial reparation liquid of acne skin, is prepared (volume ratio), monomer silver aqueous solution 2.5%, hydrolyzed pearl solution by following raw materials
3%, gulfweed extract 30%, hyaluronic acid 3%, surplus are purified water.
The monomer silver refers to that partial size is 10-1000 nanometers of elemental metals silver particles, is prepared by pure physical method,
There are merchandise sales.The monomer silver solution refers to the argentiferous water-soluble solution of argentiferous 500-1000PPM.
Hydrolyzed pearl solution refers to: after removing calcium carbonate in pearl aqueous solution, being rich in for extraction is deposited in the form of polypeptide
Keratoprotein (amino acid) aqueous solution.Document CN104399973A discloses the production method of hydrolyzed pearl solution.
Gulfweed extract: sargassan aqueous solution is extracted using ultrasound wave auxiliary enzyme, sargassan content is in 15-
17%。
Sargassan extraction process: (1) it by the sargassum leaf of picking, cleans, dry；(2) by the horse hair of dried and clean
Algae leaf is ground；(3) powder of sargassum leaf is put into supersonic generator container, ultrasonic wave action time is 30-60 points
Clock, power 350W；(4) 10-20 times of aqueous solution then is added in the powder of the sargassum leaf after ultrasonication, stirring is equal
Even, adjusting PH is 4-6；(5) papain or cellulase 2-3% is added, keeps the temperature 1-3 hours in 50 DEG C of water-baths of water-bath,
Then PH=7.0 are adjusted with sodium hydroxide solution；(6) 0.5 hour inactivator is acted in 90 DEG C of water-baths；(7) 80 DEG C of water-baths 2.5
Hour, it 2000 revs/min, is centrifuged 10 minutes, supernatant water-bath is concentrated by evaporation to 1/4 volume, and 3 times of 95% second of volume are added
Alcohol；(8) alcohol precipitation 12-18 hours, supernatant is abandoned, 3000 revs/min, is centrifuged 10 minutes, sediment is dried in vacuo thick up to sargassum
Polysaccharide.
The optimal processing parameter of ultrasound wave auxiliary enzyme method extraction sargassan are as follows: ultrasonic wave action time is 40 minutes,
Power is 350W, and operating temperature is 80 DEG C, 44.95 DEG C of hydrolysis temperature, enzymatic hydrolysis pH5.0, enzymolysis time 2.05 hours, enzyme additive amount
2.5%.Under the technological parameter, sargassum coarse polysaccharide extractive rate can reach 17%.
Hyaluronic acid is a kind of multi-functional matrix, and hyaluronic acid (sodium hyaluronate) HA is distributed widely in partes corporis humani position.Wherein
Skin also contains a large amount of hyaluronic acid.The content and metabolism of human skin maturation and ageing process also with hyaluronic acid
And change, it can improve skin-nourishing metabolism, make skin it is tender, it is smooth, go wrinkle, increase elasticity, prevent aging, in moisturizing
It is again simultaneously good skin penetration enhancer.It is used cooperatively with other nutritional ingredients, can play and promote nutrient absorption more
Ideal effect.
The antibacterial reparation liquid of acne skin is rich in the ingredients such as hmw protein, the polysaccharide extracted from pearl, sargassum,
The dispersion protection for strengthening monomer silver, avoids the agglomeration of monomer silver, and protection and money have nourished skin.It is particularly suitable
In the skin care to antibiotic allergic human population.
The antibacterial reparation liquid of acne skin uses the sargassum on the island Beihai, Guangxi Wei Zhou, passes through ultrasonic wave extraction work
Skill reduces Extracting temperature, shortens extraction time, reduces energy consumption, while ultrasonic wave also has certain bactericidal effect, energy
Guarantee that extract liquor is unlikely to deteriorate.In raw material and preparation process, natural environmental-protective theory is realized, present invention process is simple, implements
It is easy, significant effect.
Embodiment 2
A kind of antibacterial reparation liquid of acne skin, is prepared (volume ratio), monomer silver aqueous solution 3%, hydrolyzed pearl solution by following raw materials
1%, gulfweed extract 20%, hyaluronic acid 1%, surplus are purified water.
Remaining is the same as embodiment 1.
Embodiment 3
A kind of antibacterial reparation liquid of acne skin, is prepared (volume ratio), monomer silver aqueous solution 5%, hydrolyzed pearl solution by following raw materials
5%, gulfweed extract 35%, hyaluronic acid 5%, surplus are purified water.
Remaining is the same as embodiment 1.
Claims (4)
1. a kind of antibacterial reparation liquid of acne skin, is prepared (volume ratio) by following raw materials, monomer silver aqueous solution 3-5%, pearl hydrolysis
Liquid 1-5%, gulfweed extract 20-35%, hyaluronic acid 1-5%, surplus are purified water.
2. the antibacterial reparation liquid of acne skin according to claim 1, it is characterised in that: gulfweed extract: using ultrasonic wave
Auxiliary enzymes extract sargassan aqueous solution, and sargassan content is in 15-17%.
3. the antibacterial reparation liquid of acne skin according to claim 2, it is characterised in that: sargassan extraction process: (1) will
The sargassum leaf of picking, cleans, dries；(2) the sargassum leaf of dried and clean is ground；(3) powder of sargassum leaf is put into
Into supersonic generator container, ultrasonic wave action time is 30-60 minutes, power 350W；(4) then by ultrasonication
The powder of sargassum leaf afterwards is added 10-20 times of aqueous solution, stirs evenly, and adjusting PH is 4-6；(5) be added papain or
Cellulase 2-3% keeps the temperature 1-3 hours in 50 DEG C of water-baths of water-bath, then adjusts PH=7.0 with sodium hydroxide solution；(6) in
90 DEG C of water-baths act on 0.5 hour inactivator；(7) 80 DEG C water-bath 2.5 hours, 2000 revs/min, be centrifuged 10 minutes, supernatant
Liquid water-bath is concentrated by evaporation to 1/4 volume, and 3 times of 95% ethyl alcohol of volume are added；(8) alcohol precipitation 12-18 hours, abandoning supernatant, 3000 revs/min
Clock is centrifuged 10 minutes, and sediment is dried in vacuo up to sargassum Thick many candies.
4. the antibacterial reparation liquid of acne skin according to claim 3, it is characterised in that: ultrasonic wave action time is 40 minutes,
Power is 350W, and operating temperature is 80 DEG C, 44.95 DEG C of hydrolysis temperature, enzymatic hydrolysis pH5.0, enzymolysis time 2.05 hours, enzyme additive amount
2.5%。
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3136653A1 (en) * | 2022-06-20 | 2023-12-22 | Odycea | SARGASSUM MUTICUM EXTRACTS FOR THE MAINTENANCE OR TREATMENT OF OILY AND/OR ACNE PRONE SKIN |
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| CN101697954A (en) * | 2009-10-19 | 2010-04-28 | 海南京润珍珠生物技术股份有限公司 | Anti-wrinkle emulsion with pearl hydrolyzate liposome |
| CN104399973A (en) * | 2014-12-11 | 2015-03-11 | 北海银源医药科技有限公司 | Disperse protective agent prepared from pearl and momordica grosvenori extract and application thereof |
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| CN101697954A (en) * | 2009-10-19 | 2010-04-28 | 海南京润珍珠生物技术股份有限公司 | Anti-wrinkle emulsion with pearl hydrolyzate liposome |
| CN104399973A (en) * | 2014-12-11 | 2015-03-11 | 北海银源医药科技有限公司 | Disperse protective agent prepared from pearl and momordica grosvenori extract and application thereof |
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| FR3136653A1 (en) * | 2022-06-20 | 2023-12-22 | Odycea | SARGASSUM MUTICUM EXTRACTS FOR THE MAINTENANCE OR TREATMENT OF OILY AND/OR ACNE PRONE SKIN |
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