CN109613941A - A kind of digestion instrument double temperature control device - Google Patents

A kind of digestion instrument double temperature control device Download PDF

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Publication number
CN109613941A
CN109613941A CN201811305440.2A CN201811305440A CN109613941A CN 109613941 A CN109613941 A CN 109613941A CN 201811305440 A CN201811305440 A CN 201811305440A CN 109613941 A CN109613941 A CN 109613941A
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China
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water
temperature
water outlet
water inlet
end cover
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CN201811305440.2A
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CN109613941B (en
Inventor
李定中
姚鹏志
宋水军
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LUGEN INSTRUMENT (ZHENJIANG) CO Ltd
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LUGEN INSTRUMENT (ZHENJIANG) CO Ltd
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    • GPHYSICS
    • G05CONTROLLING; REGULATING
    • G05DSYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D23/00Control of temperature
    • G05D23/19Control of temperature characterised by the use of electric means
    • G05D23/20Control of temperature characterised by the use of electric means with sensing elements having variation of electric or magnetic properties with change of temperature

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Automation & Control Theory (AREA)
  • Devices For Medical Bathing And Washing (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The invention proposes a kind of digestion instrument double temperature control devices, including water bath, water bath is equipped with the first water inlet and the first water outlet, a tee tube is respectively equipped on first water inlet and the first water outlet, the first interface of two tee tubes is respectively and fixedly connected on the first water inlet and the first water outlet, and connect between the second interface of two tee tubes the first water pump and heating mechanism form temperature control loop;Heating mechanism is equipped with the first temperature element, is additionally provided with the second temperature element in water bath, the first temperature element and the second temperature element are connected with temperature sampler respectively;The present invention is arranged using double temperature control, ensure that the accuracy of temperature, increases experiment by accuracy, meanwhile, secondary use also is subject to the water in the water bath of digestion instrument, has saved efficiency.

Description

A kind of digestion instrument double temperature control device
Technical field
The present invention relates to a kind of temperature control device, in particular to a kind of digestion instrument double temperature control device.
Background technique
Drug dissolution refers to drug in regulation medium, under certain condition, from the solid pharmaceutical preparations such as tablet or capsule The speed of dissolution and the degree of dissolution.Drug dissolution directly affects the absorption and utilization of drug in vivo, is evaluation medicinal substances In index in one of amount.In drug production testing, clinical efficacy investigation, stability of drug products inspection, new drug development, prescription sieve Many aspects such as choosing, process modification will investigate this index.Drug dissolution inspection is evaluation preparation quality and technological level A kind of effective means, and evaluation agent activity ingredients Biogenic availability and the preparation uniformity a kind of effective standard, can have Effect distinguishes the difference of same drug bioavailability, therefore is one of drug quality control essential items for inspection.
All medicament dissolution instruments for belonging to manual sampling and artificial fluid infusion domestic at present, the temperature monitoring method of water bath are Using 1 temperature element, and without the stripping cup cap for being exclusively used in temperature element test point, also without novel visualization temperature correction and Thermostatic control panel.Its shortcoming and defect has two o'clock: 1. instrument computer cannot collect any 2 typical cases in synchronization The temperature of test point, can not the inside and outside real time temperature of synchronization measurement stripping rotor.It is unfavorable for adjustment heating in real time rapidly Strategy, with the preset temperature of the controlled water bath of the realization of fast uniform.2. due to there is no to visualize temperature correction and thermostatic control Panel causes the temperature-controlled precision of water bath low so operator is difficult itself error of amendment temperature element accurately and timely, Each point temperature equalization is poor in water bath, and the temperature time up to standard is very long, temperature control low efficiency.
Patent 201520334034.4 discloses the device for monitoring temperature of medicament dissolution instrument, along the water bath of medicament dissolution instrument Surrounding be uniformly arranged the second thermometer hole, in the second thermometer hole be arranged the first removable temperature element, in medicament dissolution instrument First thermometer hole is set on the cup lid of stripping rotor, and the second removable temperature element is set in the first thermometer hole;Described first Removable temperature element and the second removable temperature element are connected with central processing unit respectively, central processing unit and display unit phase Even.The present invention uses two removable temperature elements, is monitored to the temperature of medicament dissolution instrument.Avoid an original thermometric Element it is inconvenient for use, after fixing the first removable temperature element and being monitored to water bath temperature, second removable is surveyed Warm element can enter stripping rotor by the first thermometer hole and be monitored one by one to the cup temperature of multiple stripping rotors, and then conveniently make With and real time monitoring.
Above-mentioned monitoring device operation is relatively complicated, and the stability monitored and accuracy are bad.
Summary of the invention
The present invention proposes a kind of digestion instrument double temperature control device regarding to the issue above, is arranged using double temperature control, guarantees The accuracy of temperature increases experiment by accuracy, meanwhile, also secondary use is subject to the water in the water bath of digestion instrument, saved About efficiency.
Specific technical solution is as follows:
A kind of digestion instrument double temperature control device, including water bath, water bath be equipped with the first water inlet and the first water outlet, first A tee tube is respectively equipped on water inlet and the first water outlet, the first interface of two tee tubes is respectively and fixedly connected to the first water inlet On mouth and the first water outlet, connect between the second interface of two tee tubes the first water pump and heating mechanism form temperature control loop;
Heating mechanism includes horizontally disposed heating pipe, and the both ends of heating pipe pass through first end cover respectively and second end cover adds With closing, first end cover is equipped with electric heating tube, and electric heating tube insertion is arranged in heating pipe, and second end cover is equipped with second Water outlet;The tube wall of heating pipe is equipped with the first transfer tube and the second transfer tube, and the first transfer tube is located at first end cover side, Second transfer tube is located at second end cover side, and the second transfer tube is equipped with the first temperature element, and the first temperature element passes through second Transfer tube extends in heating pipe;
The second interface of the tee tube of first water outlet is connected by pipeline with the entrance of the first water pump, the outlet of the first water pump It is connected by pipeline with the first transfer tube, the second water outlet in second end cover is by pipeline and is located on the first water inlet The second interface of tee tube is connected;
The second temperature element is additionally provided in water bath, the first temperature element and the second temperature element are connected with temperature sampler respectively It connects.
Further, it is mended between the third interface of two tee tubes by the second water pump of placed in series and fluid infusion cup, formation Liquid keeps the temperature circuit;
Fluid infusion cup includes cup body, and interlayer is arranged outside cup body, and interlayer is equipped with third water inlet and third water outlet;
Water in water bath is passed through in interlayer by the second water pump by third water inlet, then is expelled to water bath from third water outlet In.
Further, third water inlet is located at the lower section of water outlet.
Further, interlayer includes external jacket and cover board, and external jacket is set in outside cup body, and the height of external jacket is greater than cup The height of body is flush at the top of the top of external jacket and cup body, and cover plate lid is located at the top of external jacket and cup body, external jacket, Cover board and cup body are integrally formed formula structure, and third water inlet and third water outlet are arranged on external jacket.
Application method of the invention is as follows:
(1) in temperature control loop, the water in water bath is extracted out from the first water outlet, is passed through under the extraction effect of the first water pump It after heating mechanism heating, then is returned in water bath by the first water inlet, in cyclic process, passes through the first temperature element and the Two temperature elements carry out dual temperature control, and the temperature in water bath is made to be maintained at 37 DEG C;
(2) in fluid infusion heat preservation circuit, solvent is added into cup body, meanwhile, the water in water bath is passed through by the second water pump Third water inlet is passed through in interlayer, then is expelled in water bath from third water outlet, to realize that the solvent temperature in cup body is kept Within the scope of 37 ± 0.5 °C.
The invention has the benefit that
(1) present invention realizes dual temperature control, and temperature-controlled precision accurately reaches ± 0.1 °C;When a temperature sensor fails, separately Outer one can also play the role of temperature control;When needing to reach set temperature, set temperature can be slowly reached, it is ensured that stablize Property;It is arranged simultaneously using double temperature control, further ensures the accuracy of temperature, increases experiment by accuracy;
(2) for the present invention for guaranteeing the temperature of solvent to be supplemented, stability is good, ensure that the accuracy of experimental data;
(3) water inlet is located at the lower section of water outlet, can effectively ensure that the stability of the water temperature in interlayer, avoids the portion in interlayer Hot water is divided to cause thermal loss without circulation;
(4) structure setting of interlayer ensure that the intracorporal solvent of cup is heated evenly, ensure that experiment effect.
Detailed description of the invention
Fig. 1 is structure of the invention figure.
Fig. 2 is heating mechanism cross-sectional view.
Fig. 3 is present system connection figure.
Fig. 4 is the cross-sectional view of fluid infusion cup in embodiment one.
Fig. 5 is the cross-sectional view of fluid infusion cup in embodiment two.
Fig. 6 is the cross-sectional view that water outlet and pipeline are connected by retention mechanism in Fig. 5.
Fig. 7 is the cross-sectional view of water outlet in Fig. 6.
Fig. 8 is the cross-sectional view of conversion terminal in Fig. 6.
Fig. 9 is the right view of inner sleeve in Fig. 6.
Figure 10 is the cross-sectional view of pipeline in Fig. 6.
Figure 11 is the left view of Figure 10
Figure 12 is the cross-sectional view of the second grafting item in Figure 11.
Specific embodiment
Clear to be more clear technical solution of the present invention, the present invention is described further with reference to the accompanying drawing, The technical characteristic of any pair of technical solution of the present invention carries out the scheme that equivalencing is obtained with conventional reasoning and each falls within guarantor of the present invention Protect range.
Description of symbols
Water bath 1, the first water inlet 2, the first water outlet 3, tee tube 4, the first water pump 5, heating mechanism 6, heating pipe 7, One end cap 8, second end cover 9, electric heating tube 10, the second water outlet 11, the first transfer tube 12, the second transfer tube 13, the first thermometric It is element 14, the second temperature element 15, the second water pump 16, fluid infusion cup 17, cup body 25, interlayer 26, water inlet 27, water outlet 28, outer Collet 29, cover board 210, retention mechanism 211, conversion terminal 212, inner sleeve 213, outer sleeve 214, the first adapter ring 215, second Adapter ring 216, third adapter ring 217, the first slot 218, limit raised line 219, the second slot 220, the first grafting article 221, the Three slots 222, the second grafting article 223, the 4th slot 224, cushion chamber 225, pressure tank 226, briquetting 227, pipeline 228, limit Groove 229.
Embodiment one
A kind of digestion instrument double temperature control device as shown in the figure, including water bath 1, water bath are equipped with the first water inlet 2 and first A tee tube 4, the first interface difference of two tee tubes are respectively equipped on water outlet 3, the first water inlet and the first water outlet It is fixed on the first water inlet and the first water outlet, connect between the second interface of two tee tubes the first water pump 5 and heater Structure 6 forms temperature control loop;
Heating mechanism includes horizontally disposed heating pipe 7, and the both ends of heating pipe pass through first end cover 8 and second end cover respectively 9 are closed, and first end cover is equipped with electric heating tube 10, and electric heating tube insertion is arranged in heating pipe, sets in second end cover There is the second water outlet 11;The tube wall of heating pipe is equipped with the first transfer tube 12 and the second transfer tube 13, the first transfer tube are located at First end cover side, the second transfer tube are located at second end cover side, and the second transfer tube is equipped with the first temperature element 14, and first surveys Warm element passes through the second transfer tube and extends in heating pipe;
The second interface of the tee tube of first water outlet is connected by pipeline with the entrance of the first water pump, the outlet of the first water pump It is connected by pipeline with the first transfer tube, the second water outlet in second end cover is by pipeline and is located on the first water inlet The second interface of tee tube is connected;
Be additionally provided with the second temperature element 15 in water bath, the first temperature element and the second temperature element respectively with temperature sampler phase Connection.
Further, temperature sampler is also connected with controller, and controller is connected with electric heater.
Further, pass through the second water pump of placed in series 16 and fluid infusion cup 17, shape between the third interface of two tee tubes Circuit is kept the temperature at fluid infusion;
Fluid infusion cup includes cup body 25, and interlayer 26 is arranged outside cup body, and interlayer is equipped with third water inlet 27 and third water outlet 28;
Water in water bath is passed through in interlayer by the second water pump by third water inlet, then is expelled to water bath from third water outlet In.
Further, third water inlet is located at the lower section of water outlet.
Further, interlayer includes external jacket 29 and cover board 210, and external jacket is set in outside cup body, the height of external jacket It greater than the height of cup body, is flush at the top of the top of external jacket and cup body, cover plate lid is located at the top of external jacket and cup body, outside Collet, cover board and cup body are integrally formed formula structure, and third water inlet and third water outlet are arranged on external jacket.
In the present embodiment, 228 pipelines are arranged respectively on the third water inlet and third water outlet for being fixed on interlayer.
First temperature element and the second temperature element are the temperature sensing purchased from hundred million Du Da Electromechanical Technology Co., Ltd of Wuxi Device 18B20;
Controller is purchased from Zhengjiang City capital mouthful essence with the PLC XC5-24 of electromechanical research and development centre;
Temperature sampler is the TAM-18B20-4L temperature collecting module purchased from Nanhai District Foshan City bright positive electron scientific and technical research room;
Electric heater is the heater 1200W 220V SS316 purchased from Jiangsu male justice environmentally friendly automation equipment Co., Ltd.
Application method of the invention is as follows:
(1) in temperature control loop, the water in water bath is extracted out from the first water outlet, is passed through under the extraction effect of the first water pump It after heating mechanism heating, then is returned in water bath by the first water inlet, in cyclic process, passes through the first temperature element and the Two temperature elements carry out dual temperature control, and the temperature in water bath is made to be maintained at 37 DEG C;
(2) in fluid infusion heat preservation circuit, solvent is added into cup body, meanwhile, the water in water bath is passed through by the second water pump Third water inlet is passed through in interlayer, then is expelled in water bath from third water outlet, to realize that the solvent temperature in cup body is kept Within the scope of 37 ± 0.5 °C.
Embodiment two
With a kind of digestion instrument fluid infusion mechanism described in embodiment one, the difference is that:
Interlayer includes external jacket 29 and cover board 210, and external jacket is set in outside cup body, and the height of external jacket is greater than the height of cup body Degree is flush at the top of the top of external jacket and cup body, and cover plate lid is located at the top of external jacket and cup body, external jacket, cover board and Cup body is integrally formed formula structure, and inlet and outlet are arranged on external jacket.
In the present embodiment, pipeline 228 is connected to the third water inlet and third water outlet of interlayer by retention mechanism 211 On.
Retention mechanism includes conversion terminal 212, inner sleeve 213 and outer sleeve 214;
Conversion terminal includes the first adapter ring 215, the second adapter ring 216 and third adapter ring 217 of integral structure, and first turn It connects and is equipped with interconnected Switching-through channel in ring, the second adapter ring and third adapter ring, the outer diameter of the second adapter ring is greater than third The outer diameter of adapter ring;
First adapter ring is equipped with the first slot 218, and the inner wall of the first slot is equipped with the limiting groove of multiple cirque structures 229, the cross sectional shape of limiting groove is isosceles triangular structure, axial on the outer wall of the first slot to be equipped at least two evacuation Slot, when free state, the outer wall of the first slot slopes inwardly setting;
First adapter ring is set on the water inlet or water outlet of cylindrical structure, and water inlet or water outlet is made to be inserted into the first slot In, it is arranged in the corresponding insertion limiting groove of limit raised line 219 on water inlet or water outlet outer wall;
Inner sleeve is set in the outside of third adapter ring and is pressed on the second adapter ring, and the inner wall of inner sleeve is equipped with second Slot 220, the second slot are contrary with the first slot;
The height of inner sleeve is less than the height of third adapter ring;
Pipeline is set on the outer wall of third adapter ring and in the second slot of insertion for being interference fitted, outer sleeve be set in pipeline, The outside of inner sleeve and the second adapter ring and outer sleeve, which pass through to be threadedly engaged, to be locked on the outer wall of the second adapter ring, from And be locked to pipeline, realize the connection of pipeline and water inlet or water outlet.
Further, multiple first grafting items 221, the first grafting item are equipped at circle-shaped on the outer wall of third adapter ring Prolong the axial of third adapter ring to be arranged, in the third slot 222 of the corresponding insertion inner sleeve of the first grafting item.
Further, on the outer wall of pipeline inserted terminal circumferentially shape be equipped with multiple second grafting items 223, the second grafting item In the 4th slot 224 on corresponding insertion the second slot of inner sleeve inner wall;
The top of second grafting item is protruding upward at segment structure, and cushion chamber 225, the bottom of cushion chamber are equipped in the second grafting item Equipped with pressure tank 226, the top of cushion chamber is equipped with briquetting 227, and when the second grafting article is inserted into the 4th slot, briquetting insertion is held In indent.
When installation, inner sleeve is set on third transfer tube, is inserted into the inserted terminal of pipeline, then outer sleeve is threadedly engaged Be locked on the second transfer tube, finally the first transfer tube, which is set on water inlet or water outlet, can be realized connection.
In the present invention, pipeline and water inlet, water outlet are connected by retention mechanism, easy to operate, fastness Good, stability is good, is not easy to loosen, more securely and reliably.

Claims (3)

1. a kind of digestion instrument double temperature control device, it is characterized in that, including water bath, water bath is equipped with the first water inlet and first A tee tube is respectively equipped on water outlet, the first water inlet and the first water outlet, the first interface of two tee tubes is solid respectively It connects on the first water inlet and the first water outlet, connect between the second interface of two tee tubes the first water pump and heating mechanism, Form temperature control loop;
Heating mechanism includes horizontally disposed heating pipe, and the both ends of heating pipe pass through first end cover respectively and second end cover adds With closing, first end cover is equipped with electric heating tube, and electric heating tube insertion is arranged in heating pipe, and second end cover is equipped with second Water outlet;The tube wall of heating pipe is equipped with the first transfer tube and the second transfer tube, and the first transfer tube is located at first end cover side, Second transfer tube is located at second end cover side, and the second transfer tube is equipped with the first temperature element, and the first temperature element passes through second Transfer tube extends in heating pipe;
The second interface of the tee tube of first water outlet is connected by pipeline with the entrance of the first water pump, the outlet of the first water pump It is connected by pipeline with the first transfer tube, the second water outlet in second end cover is by pipeline and is located on the first water inlet The second interface of tee tube is connected;
The second temperature element is additionally provided in water bath, the first temperature element and the second temperature element are connected with temperature sampler respectively It connects.
2. a kind of digestion instrument double temperature control device as described in claim 1, it is characterized in that, the third interfaces of two tee tubes it Between by the second water pump of placed in series and fluid infusion cup, form fluid infusion and keep the temperature circuit;
Fluid infusion cup includes cup body, and interlayer is arranged outside cup body, and interlayer is equipped with third water inlet and third water outlet;
Water in water bath is passed through in interlayer by the second water pump by third water inlet, then is expelled to water bath from third water outlet In.
3. a kind of digestion instrument double temperature control device as claimed in claim 2, it is characterized in that, third water inlet is located at water outlet Lower section.
CN201811305440.2A 2018-11-05 2018-11-05 Double temperature control device of dissolution instrument Active CN109613941B (en)

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Application Number Priority Date Filing Date Title
CN201811305440.2A CN109613941B (en) 2018-11-05 2018-11-05 Double temperature control device of dissolution instrument

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Application Number Priority Date Filing Date Title
CN201811305440.2A CN109613941B (en) 2018-11-05 2018-11-05 Double temperature control device of dissolution instrument

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CN109613941A true CN109613941A (en) 2019-04-12
CN109613941B CN109613941B (en) 2024-10-22

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Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4625096A (en) * 1984-10-01 1986-11-25 American Hospital Supply Corporation Liquid bath temperature control
CN2890798Y (en) * 2006-01-24 2007-04-18 深圳市科威信机电设备有限公司 Water bath drying tank
CN203494530U (en) * 2013-09-11 2014-03-26 广东交通职业技术学院 Constant-temperature water bathing device for detecting quality of asphalt
CN204404497U (en) * 2015-01-19 2015-06-17 王水明 A kind of constent temperature heater
CN105841338A (en) * 2016-06-15 2016-08-10 苏州畅昇电子科技有限公司 Temperature-controllable liquid heating device
CN205980264U (en) * 2016-08-29 2017-02-22 岑占波 Heating pipe
CN206927645U (en) * 2017-03-27 2018-01-26 广州奇美纯水设备科技有限公司 A kind of electrical heated pipings chlorination equipment
CN108717014A (en) * 2018-05-30 2018-10-30 浙江大学宁波理工学院 Water recycles temperature control one-dimensional consolidation instrument
CN208636728U (en) * 2018-11-05 2019-03-22 禄根仪器(镇江)有限公司 A kind of digestion instrument double temperature control device

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4625096A (en) * 1984-10-01 1986-11-25 American Hospital Supply Corporation Liquid bath temperature control
CN2890798Y (en) * 2006-01-24 2007-04-18 深圳市科威信机电设备有限公司 Water bath drying tank
CN203494530U (en) * 2013-09-11 2014-03-26 广东交通职业技术学院 Constant-temperature water bathing device for detecting quality of asphalt
CN204404497U (en) * 2015-01-19 2015-06-17 王水明 A kind of constent temperature heater
CN105841338A (en) * 2016-06-15 2016-08-10 苏州畅昇电子科技有限公司 Temperature-controllable liquid heating device
CN205980264U (en) * 2016-08-29 2017-02-22 岑占波 Heating pipe
CN206927645U (en) * 2017-03-27 2018-01-26 广州奇美纯水设备科技有限公司 A kind of electrical heated pipings chlorination equipment
CN108717014A (en) * 2018-05-30 2018-10-30 浙江大学宁波理工学院 Water recycles temperature control one-dimensional consolidation instrument
CN208636728U (en) * 2018-11-05 2019-03-22 禄根仪器(镇江)有限公司 A kind of digestion instrument double temperature control device

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