CN109608444B - 含异吲哚啉酮的erk抑制剂及其制备方法与用途 - Google Patents

含异吲哚啉酮的erk抑制剂及其制备方法与用途 Download PDF

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CN109608444B
CN109608444B CN201811424530.3A CN201811424530A CN109608444B CN 109608444 B CN109608444 B CN 109608444B CN 201811424530 A CN201811424530 A CN 201811424530A CN 109608444 B CN109608444 B CN 109608444B
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arh
compound
acid
dichloromethane
pharmaceutically acceptable
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CN109608444A (zh
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徐云根
纪德重
张灵芝
朱启华
柏英
吴尧尧
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China Pharmaceutical University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201811424530.3A 2018-11-27 2018-11-27 含异吲哚啉酮的erk抑制剂及其制备方法与用途 Active CN109608444B (zh)

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CN201811424530.3A CN109608444B (zh) 2018-11-27 2018-11-27 含异吲哚啉酮的erk抑制剂及其制备方法与用途
PCT/CN2019/104110 WO2020107987A1 (fr) 2018-11-27 2019-09-03 Inhibiteur de erk comprenant de l'isoindoline, son procédé de préparation et son utilisation

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CN201811424530.3A CN109608444B (zh) 2018-11-27 2018-11-27 含异吲哚啉酮的erk抑制剂及其制备方法与用途

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CN109608444A CN109608444A (zh) 2019-04-12
CN109608444B true CN109608444B (zh) 2022-02-11

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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109608444B (zh) * 2018-11-27 2022-02-11 中国药科大学 含异吲哚啉酮的erk抑制剂及其制备方法与用途
JP7409719B2 (ja) * 2019-12-06 2024-01-09 徳昇済医薬（無錫）有限公司 Ｅｒｋ阻害剤としてのチアゾロラクタム系化合物およびその使用
CN113248482B (zh) * 2020-02-10 2022-08-26 中国药科大学 含苯并五元杂环结构的化合物及其制备方法与用途
IL297743B2 (en) 2020-04-30 2024-06-01 Medshine Discovery Inc Compounds containing benzosulatum
WO2022253186A1 (fr) * 2021-06-02 2022-12-08 南京明德新药研发有限公司 Forme cristalline de composé de thiazolopyrrolone à substitution diméthyle et son procédé de préparation
CN115594681B (zh) * 2022-10-21 2024-06-18 广州六顺生物科技有限公司 一种异吲哚啉-1,3-二酮衍生物及其应用
CN117164597B (zh) * 2023-11-02 2024-02-09 深圳创元生物医药科技有限公司 一种smtp-0合成方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1494541A (zh) * 2001-02-09 2004-05-05 ��̩��˹ҩ��ɷ����޹�˾ Erk2的杂环抑制剂及其应用
CN1953974A (zh) * 2004-05-14 2007-04-25 辉瑞产品有限公司 治疗异常细胞生长的嘧啶衍生物
CN107922387A (zh) * 2015-06-15 2018-04-17 阿沙纳生物科学公司 Erk1与erk2的杂环抑制剂及其在癌症治疗中的应用
CN108617166A (zh) * 2015-10-21 2018-10-02 大冢制药株式会社 蛋白激酶抑制剂苯并内酰胺化合物
WO2018193410A1 (fr) * 2017-04-20 2018-10-25 Otsuka Pharmaceutical Co., Ltd. Dérivé de 6-pyrimidine-isoindole utilisé en tant qu'inhibiteur de erk1/2

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8338439B2 (en) * 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
US9938269B2 (en) * 2011-06-30 2018-04-10 Abbvie Inc. Inhibitor compounds of phosphodiesterase type 10A
GEP20196983B (en) * 2014-01-14 2019-06-25 Millennium Pharm Inc Heteroaryls and uses thereof
CN109608444B (zh) * 2018-11-27 2022-02-11 中国药科大学 含异吲哚啉酮的erk抑制剂及其制备方法与用途

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1494541A (zh) * 2001-02-09 2004-05-05 ��̩��˹ҩ��ɷ����޹�˾ Erk2的杂环抑制剂及其应用
CN1953974A (zh) * 2004-05-14 2007-04-25 辉瑞产品有限公司 治疗异常细胞生长的嘧啶衍生物
CN107922387A (zh) * 2015-06-15 2018-04-17 阿沙纳生物科学公司 Erk1与erk2的杂环抑制剂及其在癌症治疗中的应用
CN108617166A (zh) * 2015-10-21 2018-10-02 大冢制药株式会社 蛋白激酶抑制剂苯并内酰胺化合物
WO2018193410A1 (fr) * 2017-04-20 2018-10-25 Otsuka Pharmaceutical Co., Ltd. Dérivé de 6-pyrimidine-isoindole utilisé en tant qu'inhibiteur de erk1/2

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2;Tom D，等;《Journal of Medicinal Chemistry》;20180518;第61卷(第11期);4978-4992 *

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WO2020107987A1 (fr) 2020-06-04

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