CN109596778A - A kind of artificial saliva and the preparation method and application thereof for buccal cigarette research - Google Patents
A kind of artificial saliva and the preparation method and application thereof for buccal cigarette research Download PDFInfo
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- CN109596778A CN109596778A CN201811485983.7A CN201811485983A CN109596778A CN 109596778 A CN109596778 A CN 109596778A CN 201811485983 A CN201811485983 A CN 201811485983A CN 109596778 A CN109596778 A CN 109596778A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B13/00—Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff
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Abstract
The artificial saliva and preparation method thereof that the present invention provides a kind of for buccal cigarette research, belongs to artificial saliva preparation technical field.Artificial saliva of the invention is by including that the aqueous solution of following mass concentration component is prepared: NaCl 0.392~0.408g/L, KCl 0.392~0.408g/L, CaCl2·2H2O 0.7791~0.8109g/L, NaH2PO4·2H2O 0.7644~0.7956g/L, Na2S·2H20.0049~0.0051g/L of O, 0.98~1.02g/L of urea, 2.94~3.06g/L of carboxymethyl cellulose, the artificial saliva pH value are 7.0.Artificial saliva of the invention is similar to artificial saliva result to the detection of buccal cigarette nicotine;And the artificial saliva stabilization is good, has certain viscosity;Formula components type is few, and is common compounds, and cost is relatively low.
Description
Technical field
The present invention relates to artificial saliva preparation technical field more particularly to a kind of artificial saliva for buccal cigarette research and
Preparation method and application.
Background technique
At home, packed buccal cigarette is received more and more attention as a kind of new tobacco products, and use form is special
Very, buccal cigarette is placed between upper gum and upper lip when in use, by the dissolution of saliva, so that contain in buccal cigarette
Ingredient is discharged into oral cavity, is absorbed by the body.When studying the quality such as the mouthfeel of buccal cigarette, it is required to using saliva.But by
It is extremely inconvenient in a large amount of collections and preservation of true saliva, so it is true to be all made of artificial saliva replacement when carrying out the studies above
Saliva;Existing artificial saliva is mostly the inorganic salt type artificial saliva of iso standard.But in the inorganic salts using iso standard
When type artificial saliva studies buccal cigarette, the buccal cigarette nicotine content measured is higher than the measured value of true saliva, as a result not
Accurately, and then quality evaluation to buccal cigarette is influenced.
Summary of the invention
In view of this, the artificial saliva and preparation method thereof that the purpose of the present invention is to provide a kind of for buccal cigarette research
With application.It is accurate that artificial saliva provided by the invention measures the nicotine content in buccal cigarette, similar with true saliva result;Together
When, artificial saliva provided by the invention is set, with certain viscosity;And material composition type is few, at low cost.
In order to achieve the above-mentioned object of the invention, the present invention the following technical schemes are provided:
The present invention provides a kind of artificial saliva for buccal cigarette research, the artificial saliva is dense by including following quality
The aqueous solution of degree component is prepared: NaCl 0.392~0.408g/L, KCl 0.392~0.408g/L, CaCl2·2H2O
0.7791~0.8109g/L, NaH2PO4·2H2O 0.7644~0.7956g/L, Na2S·2H20.0049~0.0051g/L of O,
0.98~1.02g/L of urea, 2.94~3.06g/L of carboxymethyl cellulose, the pH value of the artificial saliva are 7.0.
Preferably, the artificial saliva is by including that the aqueous solution of following mass concentration component is prepared: NaCl 0.394
~0.406g/L, KCl 0.394~0.406g/L, CaCl2·2H2O 0.7800~0.8100g/L, NaH2PO4·2H2O
0.7650~0.7950g/L, Na2S·2H20.00495~0.00505g/L of O, 0.985~1.015g/L of urea, carboxymethyl are fine
Tie up 2.96~3.04g/L of element.
Preferably, the artificial saliva is by including that the aqueous solution of following mass concentration component is prepared: NaCl 0.398
~0.402g/L, KCl 0.398~0.402g/L, CaCl2·2H2O 0.7900~0.8000g/L, NaH2PO4·2H2O
0.7700~0.7900g/L, Na2S·2H2O 0.0050g/L, 0.99~1.01g/L of urea, carboxymethyl cellulose 2.98~
3.02g/L。
Preferably, water used in aqueous solution is deionized water in the artificial saliva.
Preferably, described NaCl, KCl, CaCl2·2H2O、NaH2PO4·2H2O、Na2S·2H2O, urea and carboxymethyl are fine
The purity of dimension element is that analysis is pure.
The present invention also provides the preparation methods of artificial saliva described in above-mentioned technical proposal, comprising the following steps:
(1) NaCl, KCl, CaCl are weighed2·2H2O、NaH2PO4·2H2O、Na2S·2H2O, urea, carboxymethyl cellulose
It is mixed with water, and concentrated hydrochloric acid is added, obtain pre- artificial saliva;
(2) it uses sodium hydroxide to adjust the pH value of the pre- artificial saliva as 7.0, obtains artificial saliva.
The present invention also provides application of the artificial saliva described in above-mentioned technical proposal in research buccal cigarette field.
The present invention provides a kind of artificial saliva for buccal cigarette research, the artificial saliva is dense by including following quality
The aqueous solution of degree component is prepared: NaCl 0.392~0.408g/L, KCl 0.392~0.408g/L, CaCl2·2H2O
0.7791~0.8109g/L, NaH2PO4·2H2O 0.7644~0.7956g/L, Na2S·2H20.0049~0.0051g/L of O,
0.98~1.02g/L of urea, 2.94~3.06g/L of carboxymethyl cellulose, the pH value of the artificial saliva are 7.0.The present invention mentions
The artificial saliva of confession is accurate to the testing result of buccal cigarette nicotine, most similar with true saliva result, can be used in buccal cigarette
Quality evaluation;Meanwhile the artificial saliva stabilization is good, and has certain viscosity, formula components type is less, and is common
Compound, cost is relatively low.Embodiment statistics indicate that: the amount of dissolution of the nicotine in true saliva and the artificial saliva prepared of the present invention
There was no significant difference for liquid;And release rule of the buccal cigarette nicotine in artificial saliva of the invention and true saliva are closest.
Detailed description of the invention
Fig. 1 is buccal cigarette nicotine release rule figure in variety classes artificial saliva.
Specific embodiment
The present invention provides a kind of artificial saliva for buccal cigarette research, the artificial saliva is dense by including following quality
The aqueous solution of degree component is prepared: NaCl 0.392~0.408g/L, KCl 0.392~0.408g/L, CaCl2·2H2O
0.7791~0.8109g/L, NaH2PO4·2H2O 0.7644~0.7956g/L, Na2S·2H20.0049~0.0051g/L of O,
0.98~1.02g/L of urea, 2.94~3.06g/L of carboxymethyl cellulose, the pH value of the artificial saliva are 7.0.
It include mass concentration in the aqueous solution of raw material of artificial saliva provided by the invention for 0.392~0.408g/L's
NaCl, preferably 0.394~0.406g/L, further preferably 0.398~0.402g/L, more preferably 0.400g/L.At this
In invention, the purity of the NaCl is preferably analyzed pure.The present invention does not have special restriction to the source of the NaCl, using this
Commercially available analysis net product known to the technical staff of field.
It include the KCl that mass concentration is 0.392~0.408g/L in the aqueous solution of raw material of artificial saliva provided by the invention,
Preferably 0.394~0.406g/L, further preferably 0.398~0.402g/L, more preferably 0.400g/L.In the present invention
In, the purity of the KCl is preferably analyzed pure.The present invention does not have special restriction to the source of the KCl, using this field skill
Commercially available analysis net product known to art personnel.
It include mass concentration in the aqueous solution of raw material of artificial saliva provided by the invention for 0.7791~0.8109g/L's
CaCl2·2H2O, preferably 0.7800~0.8100g/L, further preferably 0.7900~0.8000g/L, more preferably
0.7960~0.7980g/L.In the present invention, the CaCl2·2H2The purity of O is preferably analyzed pure, and the present invention is to described
CaCl2·2H2The source of O does not have special restriction, using commercially available analysis net product well known to those skilled in the art.
It include mass concentration in the aqueous solution of raw material of artificial saliva provided by the invention for 0.7644~0.7956g/L's
NaH2PO4·2H2O, preferably 0.7650~0.7950g/L, further preferably 0.7700~0.7900g/L, more preferably
0.7800g/L.In the present invention, the NaH2PO4·2H2The purity of O is preferably analyzed pure, and the present invention is to the NaH2PO4·
2H2The source of O does not have special restriction, using commercially available analysis net product well known to those skilled in the art.
It include mass concentration in the aqueous solution of raw material of artificial saliva provided by the invention for 0.0049~0.0051g/L's
Na2S·2H2O, preferably 0.00495~0.00505g/L, further preferably 0.0050g/L.In the present invention, described
Na2S·2H2The purity of O is preferably analyzed pure.The present invention is to the Na2S·2H2The source of O does not have special restriction, using this
Commercially available analysis net product known to the technical staff of field.
It include the urea that mass concentration is 0.98~1.02g/L in the aqueous solution of raw material of artificial saliva provided by the invention,
Preferably 0.985~1.015g/L, further preferably 0.99~1.01g/L, more preferably 1.00g/L.In the present invention, institute
State urea purity preferably analyze it is pure.The present invention does not have special restriction to the source of the urea, using art technology
Commercially available analysis net product known to personnel.
It include the carboxymethyl that mass concentration is 2.94~3.06g/L in the aqueous solution of raw material of artificial saliva provided by the invention
Cellulose, preferably 2.96~3.04g/L, further preferably 2.98~3.02g/L.In the present invention, the carboxymethyl is fine
The purity of dimension element is preferably analyzed pure.The present invention does not have special restriction to the source of the carboxymethyl cellulose, using ability
Net product is analyzed known to field technique personnel.
Water used in the aqueous solution of raw material of artificial saliva provided by the invention is preferably deionized water.In the present invention,
The pH value of the artificial saliva is 7.0.
Artificial saliva provided by the invention can nicotine content in Accurate Determining buccal cigarette, most connect with true saliva result
Closely;And the artificial saliva performance is stablized, and has certain viscosity;In addition, raw material type is few in artificial saliva formula, and it is
Common compounds, it is low in cost.
The present invention also provides the preparation methods of artificial saliva described in above-mentioned technical proposal, comprising the following steps:
(1) NaCl, KCl, CaCl are weighed2·2H2O、NaH2PO4·2H2O、Na2S·2H2O, urea, carboxymethyl cellulose
It is mixed with water, and concentrated hydrochloric acid is added, obtain pre- artificial saliva;
(2) it uses sodium hydroxide to adjust the pH value of the pre- artificial saliva as 7.0, obtains artificial saliva.
The present invention weighs NaCl, KCl, CaCl2·2H2O、NaH2PO4·2H2O、Na2S·2H2O, urea, carboxymethyl cellulose
Element and water mixing, and concentrated hydrochloric acid is added, obtain pre- artificial saliva.
The present invention is to described NaCl, KCl, CaCl2·2H2O、NaH2PO4·2H2O、Na2S·2H2O, urea, carboxymethyl are fine
Dimension element and the addition sequence of water do not have special restriction, using being optionally added sequence.Mixing of the present invention to above-mentioned substance
Mode does not have special restriction, specific as stirred using hybrid mode well known to those skilled in the art.
In the present invention, due to described NaCl, KCl, CaCl2·2H2O、NaH2PO4·2H2O、Na2S·2H2O, urea,
When carboxymethyl cellulose and water mix, it is easy to appear precipitating, so needing to be added a few drop concentrated hydrochloric acids, to eliminate precipitating.
After obtaining pre- artificial saliva, the present invention uses sodium hydroxide to adjust the pH value of the pre- artificial saliva as 7.0, obtains
Artificial saliva.In the present invention, the sodium hydrate aqueous solution that the sodium hydroxide preferred mass concentration is 20%.
In the present invention, due to NaCl, KCl, CaCl2·2H2O、NaH2PO4·2H2O、Na2S·2H2O, urea, carboxylic first
Base cellulose and water directly mix it is possible that precipitate, so needing to be added a few drop concentrated hydrochloric acids to eliminate precipitating, obtain pre- people
Work saliva, is saved, spare;The preferred matching while using when needing using artificial saliva, the hydrogen-oxygen for being 20% with mass concentration
Changing sodium to adjust the pH value of pre- artificial saliva is 7.0, obtains artificial saliva.
The present invention also provides application of the artificial saliva described in above-mentioned technical proposal in research buccal cigarette field.In this hair
In bright, the method for the application preferably includes for buccal cigarette to be dissolved in the artificial saliva, is sucked by measuring in the artificial saliva
The dissolution rate of cigarette substance, and then achieve the purpose that study buccal cigarette.
Artificial saliva of the invention can fast and accurately measure the ingredient in buccal cigarette, so can be used in sucking
The detection of cigarette component content, it is as a result similar with the result of true saliva.
Below with reference to embodiment to artificial saliva studied provided by the present invention for buccal cigarette and preparation method thereof and its
Using being described in detail, but they cannot be interpreted as limiting the scope of the present invention.
Embodiment 1
A kind of artificial saliva for buccal cigarette research, the artificial saliva is by including the water-soluble of following mass concentration component
Liquid is prepared: NaCl 0.4g/L, KCl 0.4g/L, CaCl2·2H2O 0.795g/L, NaH2PO4·2H2O 0.78g/L,
Na2S·2H2O 0.005g/L, urea 1g/L, carboxymethyl cellulose 3g/L;Water used in the aqueous solution is deionized water, the people
The pH value of work saliva is 7.0;It is named as the artificial saliva containing carboxymethyl cellulose.
Comparative example 1
Prepare ISO/TR10271 inorganic salt type artificial saliva: NaCl 0.4g/L, KCl 0.4g/L, CaCl2·2H2O
0.795g/L, NaH2PO4·2H2O 0.78g/L, Na2S·2H2O 0.005g/L, Urea 1g/L.
Comparative example 2
Prepare artificial saliva containing enzyme: NaCl 0.4g/L, KCl 0.4g/L, NaH2PO4·H2O 0.69g/L, Na2S·9H2O
0.005g/L, CaCl2·2H2O 0.795g/L, KSCN 0.3g/L, Urea 1.0g/L, amylase 59mg/L.
Comparative example 3
The saliva for collecting 5 aspirations, is stored in 4 DEG C of refrigerators.
By commercially available gold deer board buccal cigarette (black tea taste) 0.35g be respectively placed in artificial saliva of the 6mL containing carboxymethyl cellulose,
In ISO/TR10271 inorganic salt type artificial saliva, artificial saliva containing enzyme and true saliva, 37 DEG C, 30min is stood, is measured above-mentioned
In four kinds of salivas in the amount of dissolution of nicotine and residue nicotine surplus;The dissolution rate of nicotine is calculated according to formula (1),
The results are shown in Table 1.
Dissolution rate of 1 nicotine of table in different type saliva
Note: capitalization A represents the conspicuousness under 0.01 level of signifiance, and lowercase a, b are represented under 0.05 level of signifiance
Conspicuousness;A, a and b is obtained after being calculated by statistics software SAS.
As can be seen from Table 1: the amount of dissolution of the nicotine in true saliva only with the artificial saliva containing carboxymethyl cellulose without
Significant difference.Therefore, the artificial saliva containing carboxymethyl cellulose can more replace true saliva in contrast.Although inorganic salt type
Artificial saliva and artificial saliva containing enzyme and the artificial saliva containing carboxymethyl cellulose do not have a significant difference, but the two is and really
Saliva has significant difference, and the higher cost of artificial saliva containing enzyme, and not easy to maintain.Therefore, the artificial saliva of carboxymethyl cellulose
Liquid has more advantage.
Comparative example 4
On the basis of ISO/TR10271 inorganic salt type artificial saliva, different amounts of carboxymethyl cellulose and starch are added
Enzyme, and different pH is set, prepare 1~No. 9 artificial saliva of number;The component content and pH of specific artificial saliva are as shown in table 2.
The component content and pH situation of 2 number of table, 1~9 artificial saliva
By Mouthsimulator device, the artificial saliva that above-mentioned number is 1~9 is injected separately into golden deer board black tea taste and is sucked
Cigarette collects dissolution fluid in different time periods, studies the variation with the time, the changes of contents of nicotine in dissolution fluid, to study mouth
Release rule containing nicotine in cigarette;And with true saliva to refer to, shown in result figure 1.As can be seen from Figure 1: buccal cigarette nicotine
Release rule trend in the artificial saliva of different formulations is roughly the same, but immediate for this with true saliva (curve 10)
Artificial saliva (curve 8) involved in inventing.
Artificial saliva provided by the invention is accurate to the testing result of buccal cigarette nicotine, most similar with true saliva result,
It can be used in the quality evaluation of buccal cigarette;Meanwhile the artificial saliva stabilization is good, and has certain viscosity, formula components kind
Class is less, and is common compounds, and cost is relatively low.Embodiment statistics indicate that: the amount of dissolution of the nicotine in true saliva with
There was no significant difference for the artificial saliva that the present invention prepares;And release rule of the buccal cigarette nicotine in artificial saliva of the invention with
True saliva is closest.The above is only a preferred embodiment of the present invention, it is noted that for the general of the art
For logical technical staff, various improvements and modifications may be made without departing from the principle of the present invention, these improve and
Retouching also should be regarded as protection scope of the present invention.
Claims (7)
1. a kind of artificial saliva for buccal cigarette research, which is characterized in that the artificial saliva is by including following mass concentration
The aqueous solution of component is prepared: NaCl 0.392~0.408g/L, KCl 0.392~0.408g/L, CaCl2·2H2O
0.7791~0.8109g/L, NaH2PO4·2H2O 0.7644~0.7956g/L, Na2S·2H20.0049~0.0051g/L of O,
0.98~1.02g/L of urea, 2.94~3.06g/L of carboxymethyl cellulose;The pH value of the artificial saliva is 7.0.
2. artificial saliva according to claim 1, which is characterized in that the artificial saliva is by including following mass concentration group
The aqueous solution divided is prepared: NaCl 0.394~0.406g/L, KCl 0.394~0.406g/L, CaCl2·2H2O 0.7800
~0.8100g/L, NaH2PO4·2H2O 0.7650~0.7950g/L, Na2S·2H20.00495~0.00505g/L of O, urea
0.985~1.015g/L, 2.96~3.04g/L of carboxymethyl cellulose.
3. artificial saliva according to claim 1, which is characterized in that the artificial saliva is by including following mass concentration group
The aqueous solution divided is prepared: NaCl 0.398~0.402g/L, KCl 0.398~0.402g/L, CaCl2·2H2O 0.7900
~0.8000g/L, NaH2PO4·2H2O 0.7700~0.7900g/L, Na2S·2H2O 0.0050g/L, urea 0.99~
1.010g/L, 2.98~3.02g/L of carboxymethyl cellulose.
4. any one artificial saliva according to claim 1~3, which is characterized in that in the artificial saliva used in aqueous solution
Water is deionized water.
5. described in any item artificial salivas according to claim 1~3, which is characterized in that described NaCl, KCl, CaCl2·
2H2O、NaH2PO4·2H2O、Na2S·2H2O, the purity of urea and carboxymethyl cellulose is that analysis is pure.
6. the preparation method of any one of Claims 1 to 5 artificial saliva, comprising the following steps:
(1) NaCl, KCl, CaCl are weighed2·2H2O、NaH2PO4·2H2O、Na2S·2H2O, urea, carboxymethyl cellulose and water are mixed
It closes, and concentrated hydrochloric acid is added, obtain pre- artificial saliva;
(2) it uses sodium hydroxide to adjust the pH value of the pre- artificial saliva as 7.0, obtains artificial saliva.
7. the artificial saliva that preparation method described in any one of Claims 1 to 5 artificial saliva or claim 6 is prepared
Application in research buccal cigarette field.
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CN110279710A (en) * | 2019-06-12 | 2019-09-27 | 贵州四季常青药业有限公司 | A kind of artificial saliva for head and neck neoplasm radiotherapy patient oral complications |
CN111596017A (en) * | 2020-05-14 | 2020-08-28 | 扬州大学 | Method for evaluating quality of rice based on simulated oral chewing |
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CN110279710A (en) * | 2019-06-12 | 2019-09-27 | 贵州四季常青药业有限公司 | A kind of artificial saliva for head and neck neoplasm radiotherapy patient oral complications |
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Application publication date: 20190409 |