CN110279710A - A kind of artificial saliva for head and neck neoplasm radiotherapy patient oral complications - Google Patents
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Abstract
The invention belongs to pharmaceutical technology field, especially a kind of artificial saliva for head and neck neoplasm radiotherapy patient oral complications, with NaCl, KCl, CaCl2·2H2O、NaHPO4·2H2O、Na2S·2H2O, Urea and distilled water are raw material, pass through reasonable proportion design, keep it close on ingredient with the true saliva of human oral cavity, have the characteristics that in good taste, non-stimulated, significant in efficacy, has for clinical common complications such as radioactivity xerostomia, mucositis caused by head and neck neoplasm radiotherapy, ulcer, saprodontia, gingivitis, periodontosis, alveolar abscess, sense of taste declines and good treat and prevent effect.
Description
Technical field
The invention belongs to pharmaceutical technology field, especially a kind of people for head and neck neoplasm radiotherapy patient oral complications
Work saliva.
Background technique
Head and neck neoplasm (nasopharyngeal carcinoma, carcinoma of mouth and laryngocarcinoma etc.) is one of clinical common cancer, and radiotherapy is in incidence
It plays a significant role in oncotherapy；Since head and neck neoplasm adjoins oral cavity normal tissue more, radiotherapy inevitably results in difference
Degree saliva of buccal cavity gland, mucosal epithelial cells radiation damage cause salivary secretion reduction, pH value decline, flora imbalance etc. to be made
It is clinical common at radioactivity xerostomia, mucositis, ulcer, saprodontia, gingivitis, periodontosis, alveolar abscess, sense of taste decline etc.
Complication seriously affects radiotherapeutic effect and life in patients；Currently, due to still lacking radiotherapy oral complications specific medicament,
And symptomatic treatment effect is bad；Such as using pilocarpinum as the M cholinergic receptor agonist of representative, although symptom can be improved,
But need long-term administration, thereby increases and it is possible to cause Systemic reaction；And use artificial saliva treatment xerostomia existing for many years, it compares
Method is gargled in traditional containing, dosage is low, and it is easy to carry, however artificial saliva period when alleviating mouth parched symptom is longer at present, it is antibacterial
Effect is undesirable, is easy to run off；The artificial saliva as disclosed in patent CN1130066A, by plurality of inorganic salt, preservative and sterile
The mixed preparings such as distilled water form, but its, poor taste short there are action time, the problems such as being easy to run off；For another example patent
Artificial saliva disclosed in CN105147818A, main component are chitosan and grapefruit seed extract with water for injection or pure
Change water to be formulated for carrier, which is suitable for peri-operation period and tumour, chemicotherapy patient's dry are alleviated, and treats and pre-
It is anti-to treat because xerostomia causes complication because hypoimmunity causes oral cavity flora is unbalance to cause intractable oral cavity ulcer,
But its treatment cycle is long, curative effect needs to be further increased；Therefore, now it is badly in need of a kind of for radiotherapy oral complications mechanism
, stable effect, artificial saliva curative for effect.
Summary of the invention
In order to solve the above technical problems existing in the prior art, the present invention provides one kind puts for head and neck neoplasm
Treat the artificial saliva of patient's oral complications, the raw material including following parts by weight: 0.35-0.0.45 parts of NaCl, KCl 0.35-
0.45 part, CaCl2·2H20.780-0.810 parts of O, NaHPO4·2H20.75-0.85 parts of O, Na2S·2H2O 0.0045-
0.0055 part, 0.8-1.2 parts of Urea, 1000 parts of distilled water.
Further, the raw material including following parts by weight: 0.4 part of NaCl, 0.4 part of KCl, CaCl2·2H2O 0.795
Part, NaHPO4·2H20.78 part of O, Na2S·2H20.005 part of O, 1 part of Urea, 1000 parts of distilled water.
It further, further include the hydroxymethyl cellulose for having 9-11 parts by weight in the raw material.
It further, further include the NaF for having 0.45-0.55 parts by weight in the raw material.
Further, further include the acetic acid chlorhexidine for there are 1-3 parts by weight in the raw material, be added into raw material, it can
Enhance artificial saliva to Gram-negative bacteria, gram-positive bacteria and Candida albicans bacteriostasis.
Further, the artificial saliva and the drug combination with Yin-nourishing and body fluid promoting, heat-clearing toxin-expelling functions.
Further, the medicine material is Radix Ophiopogonis 140-160 part, 50-70 parts of honeysuckle, dark plum 40- in parts by weight
60 parts, 10-30 parts of Radix Glycyrrhizae.
Further, further include the flavor being made of glycerol, Natural menthol, acesulfame potassium, flavorant in raw material, use
It is cool and refreshing in lubrication oral cavity, minty note, the sense of taste is stimulated, oral cavity malaise symptoms are alleviated.
Further, the glycerol, Natural menthol, acesulfame potassium, flavorant dosage be followed successively by 15-25 parts by weight,
2-4 parts by weight, 9-11 parts by weight, 1-2 parts by weight.
Further, the artificial saliva is in preparation for the application in mouth disease product.
Artificial saliva of the present invention apply also for aphtha, oral peculiar smell, pulpitis, periapical disease, gingivitis, alveolar abscess,
The treatment of the mouth diseases such as periodontal abscess, pericoronitis and extraction indication.
It is a further object to provide the preparation methods of the artificial saliva, measure purified water, heating according to formula
To 85-95 DEG C, NaCl, KCl, CaCl is added2·2H2O、NaHPO4·2H2O、Na2S·2H2O and Urea, after stirring and dissolving, then
NaF and hydroxymethyl cellulose are sequentially added, successively after stirring and dissolving, the NaOH adjustment pH to 6.6-7.1 of 1mol/L, heating is added
20-30min is boiled, stirring is cooled to room temperature.
Beneficial effect
Artificial saliva of the present invention is mainly with NaCl, KCl, CaCl2·2H2O、NaHPO4·2H2O、Na2S·2H2O, Urea and
Distilled water is raw material, by reasonable proportion design, keeps it close on ingredient with the true saliva of human body, have it is in good taste,
Feature non-stimulated, significant in efficacy, by the way that NaOH is added, so that the pH value of artificial saliva is close to human oral cavity pH value, by adding
Enter hydroxymethyl cellulose, reinforces product and holding capacity is moistened to oral cavity, then NaF is cooperated to be added, can be formed in enamel surface
Calcirm-fluoride prevents caries bacteria from producing acid, is alternatively arranged as temporary barrier when acid attack, to promote Enamel remineralizations, prevention is put
Penetrating property saprodontia occurs.Secondly, by cooperating with Yin-nourishing and body fluid promoting, removing summer-heat antidote, the yin of body caused by effective treatment radiation
Abnormal heat toxication.Thirdly, by adding acetic acid chlorhexidine, stable fungistatic effect is further ensured that.Finally, passing through addition flavour
Agent: glycerine lubrication oral cavity, food flavor (mint flavored freshener) and Natural menthol are cool and refreshing, stimulation sense of taste etc., further
Alleviate oral cavity malaise symptoms.Thus it constitutes for radioactivity xerostomia, mucositis caused by head and neck neoplasm radiotherapy, burst
The clinical common complications such as ulcer, saprodontia, gingivitis, periodontosis, alveolar abscess, sense of taste decline are imitated with good treatment and prevention
Fruit.
Specific embodiment
With reference to embodiment, technical solution of the present invention is further limited, but claimed range is not
It is limited only to made description.
Embodiment 1
A kind of artificial saliva for head and neck neoplasm radiotherapy patient oral complications, the raw material including following parts by weight:
NaCl 0.35g、KCl 0.35g、CaCl2·2H2O 0.780g、NaHPO4·2H2O 0.75g、Na2S·2H2O 0.0045g、
Urea 0.8g, distilled water 1000g.
Embodiment 2
A kind of artificial saliva for head and neck neoplasm radiotherapy patient oral complications, the raw material including following parts by weight:
NaCl 0.45g、KCl 0.45g、CaCl2·2H2O 0.810g、NaHPO4·2H2O 0.85g、Na2S·2H2O 0.0055g、
Urea 1.2g, distilled water 1000g.
Embodiment 3
A kind of artificial saliva for head and neck neoplasm radiotherapy patient oral complications, the raw material including following parts by weight:
NaCl 0.4g、KCl 0.4g、CaCl2·2H2O 0.795g、NaHPO4·2H2O 0.78g、Na2S·2H2O 0.005g、Urea
1g, distilled water 1000g.
Above-described embodiment 1- embodiment 3 is prepared with the following method:
Purified water is measured according to formula, is heated to 85-95 DEG C, NaCl, KCl, CaCl is added2·2H2O、NaHPO4·
2H2O、Na2S·2H2After stirring and dissolving, the NaOH adjustment pH to 6.6-7.1 of 1mol/L is added in O and Urea, and 20- is boiled in heating
30min, stirring are cooled to room temperature.
Embodiment 4
A kind of artificial saliva for head and neck neoplasm radiotherapy patient oral complications, the raw material including following parts by weight:
NaCl 0.0.45g、KCl 0.35g、CaCl2·2H2O 0.810g、NaHPO4·2H2O 0.75g、Na2S·2H2O
0.0045g, Urea 1.2g, distilled water 1000g.
It further, further include the hydroxymethyl cellulose for having 10g in the raw material.
Embodiment 5
Same as Example 4, difference is in raw material to further include the hydroxymethyl cellulose for having 9g.
Embodiment 6
Same as Example 4, difference is in raw material to further include the hydroxymethyl cellulose for having 11g.
Above-described embodiment 4-6 is prepared with the following method:
Purified water is measured according to formula, is heated to 85-95 DEG C, NaCl, KCl, CaCl is added2·2H2O、NaHPO4·
2H2O、Na2S·2H2After stirring and dissolving, hydroxymethyl cellulose is added in O and Urea again, and successively after stirring and dissolving, 1mol/ is added
The NaOH of L adjusts pH to 6.6-7.1, and 20-30min is boiled in heating, and stirring is cooled to room temperature.
Embodiment 7
A kind of artificial saliva for head and neck neoplasm radiotherapy patient oral complications, the raw material including following parts by weight:
NaCl 0.35g、KCl 0.45g、CaCl2·2H2O 0.780g、NaHPO4·2H2O 0.85g、Na2S·2H2O 0.0055g、
Urea 0.8g, distilled water 1000g.
It further, further include the hydroxymethyl cellulose for having 10g in the raw material.
It further, further include the NaF for having 0.5g in the raw material.
Embodiment 8
Same as Example 7, difference is in raw material to further include the NaF for having 0.45g.
Embodiment 9
Same as Example 7, difference is in raw material to further include the NaF for having 0.55g.
Above-described embodiment 7-9 is prepared with the following method:
Purified water is measured according to formula, is heated to 85-95 DEG C, NaCl, KCl, CaCl is added2·2H2O、NaHPO4·
2H2O、Na2S·2H2O and Urea after stirring and dissolving, sequentially adds NaF and hydroxymethyl cellulose, successively after stirring and dissolving, adds
Enter the NaOH adjustment pH to 6.6-7.1 of 1mol/L, 20-30min is boiled in heating, and stirring is cooled to room temperature.
Embodiment 10
A kind of artificial saliva for head and neck neoplasm radiotherapy patient oral complications, the raw material including following parts by weight:
NaCl 0.42g、KCl 0.36g、CaCl2·2H2O 0.785g、NaHPO4·2H2O 0.83g、Na2S·2H2O 0.0048g、
Urea 0.9g, distilled water 1000g.
It further, further include the hydroxymethyl cellulose for having 10g in the raw material.
It further, further include the NaF for having 0.5g in the raw material.
It further, further include the acetic acid chlorhexidine for having 2g in the raw material.
Embodiment 11
Same as in Example 10, difference is in raw material to further include the acetic acid chlorhexidine for having 1g.
Embodiment 12
Same as in Example 10, difference is in raw material to further include the acetic acid chlorhexidine for having 3g.
Test example 13
A kind of artificial saliva for head and neck neoplasm radiotherapy patient oral complications, the raw material including following parts by weight:
NaCl 0.4g、KCl 0.4g、CaCl2·2H2O 0.795g、NaHPO4·2H2O 0.78g、Na2S·2H2O 0.0045-
0.005g, Urea 1g, distilled water 1000g.
It further, further include the hydroxymethyl cellulose for having 10g in the raw material.
It further, further include the NaF for having 0.5g in the raw material.
It further, further include the acetic acid chlorhexidine for having 2g in the raw material.
Further, the artificial saliva is combined with Radix Ophiopogonis 140g, honeysuckle 50g, dark plum 40g, Radix Glycyrrhizae 10g.
Embodiment 14
Identical as embodiment 13, difference is the artificial saliva and Radix Ophiopogonis 160g, honeysuckle 70g, dark plum 60g, sweet
Careless 30g is combined.
Embodiment 15
Identical as embodiment 13, difference is the artificial saliva and Radix Ophiopogonis 150g, honeysuckle 60g, dark plum 50g, sweet
Careless 20g is combined.
Embodiment 16
A kind of artificial saliva for head and neck neoplasm radiotherapy patient oral complications, the raw material including following parts by weight:
NaCl 0.35g、KCl 0.35g、CaCl2·2H2O 0.810g、NaHPO4·2H2O 0.85g、Na2S·2H2O 0.0045g、
Urea 0.8g, distilled water 1000g.
It further, further include the hydroxymethyl cellulose for having 10g in the raw material.
It further, further include the NaF for having 0.5g in the raw material.
It further, further include the acetic acid chlorhexidine for having 2g in the raw material.
Further, the artificial saliva is combined with Radix Ophiopogonis 150g, honeysuckle 60g, dark plum 50g, Radix Glycyrrhizae 20g.
It further, further include having glycerol, Natural menthol, acesulfame potassium, flavorant.
Further, the glycerol, Natural menthol, acesulfame potassium, flavorant dosage be followed successively by 15g, 2g, 9g, 1g.
Embodiment 17
Identical as embodiment 16, difference is, the glycerol, Natural menthol, acesulfame potassium, flavorant dosage successively
For 25g, 4g, 11g, 2g.
Above-described embodiment 10-17 is prepared with the following method:
Purified water is measured according to formula, is heated to 85-95 DEG C, NaCl, KCl, CaCl is added2·2H2O、NaHPO4·
2H2O、Na2S·2H2O and Urea after stirring and dissolving, sequentially adds NaF and hydroxymethyl cellulose, successively after stirring and dissolving, adds
Enter the NaOH adjustment pH to 6.6-7.1 of 1mol/L, 20-30min is boiled in heating, and stirring is cooled to room temperature.
Test example 1
According to artificial saliva prepared by the present invention, physical and chemical index detection is carried out to it, as a result such as the following table 1:
Table 1
| Testing index | Testing result |
| Appearance | It is colorless and transparent |
| Light transmittance | >=95% |
| PH value | 6.6-7.1 |
| Dynamic viscosity | ≥10mpas |
| Content of beary metal | ≤ 0.001% |
Test example 2
Take the antibacterial conditioning liquid of test example 1 at 37 DEG C of temperature, relative humidity places 6 months under the conditions of being 75%, respectively with 1,
2,3,4,5,6 the end of month samplings, test other inspection targets after comparing appearance, as a result compared with 0 month, as a result such as the following table 2；
Table 2
| Time (moon) | Shape | PH value | Viscosity (Pas) | Act on 2min time sterilizing rate |
| 0 | Colourless transparent liquid | 6.85 | 4.24 | 95.4% |
| 1 | Colourless transparent liquid | 6.86 | 4.23 | 95.1% |
| 2 | Colourless transparent liquid | 6.93 | 4.32 | 94.8% |
| 3 | Colourless transparent liquid | 6.96 | 4.37 | 94.2% |
| 4 | Colourless transparent liquid | 6.97 | 4.45 | 93.6% |
| 5 | Colourless transparent liquid | 7.02 | 4.54 | 92.5% |
| 6 | Colourless transparent liquid | 7.08 | 4.62 | 91.3% |
As test data in table 2 it is found that artificial saliva described in embodiment passes through 6 months accelerated tests, indices are equal
Without significant change, stability is good, and pH changes in human oral cavity pH value range.
Test example 3
Artificial saliva prepared by embodiment 1-17 carries out fungistatic effect test, to strain staphylococcus aureus
ATCC6538, Escherichia coli 8099, Candida albicans ATCC10231, streptococcus mutans ATCC10449, respectively act on 2min and
5min bacteriostasis rate is shown in Table 2:
Table 2
In order to further verify the fungistatic effect of artificial saliva of the present invention, with patent CN105147818A and patent
The artificial saliva of CN1130066A as a control group, carries out bacteriostatic test according to the method described above, as a result such as the following table 3 and table 4:
Table 3
| Group | 2min | 5min |
| Staphylococcus aureus ATCC6538 | 95.6% | 99.0% |
| Escherichia coli 8099 | 96.2% | 99.4% |
| Candida albicans ATCC10231 | 93.5% | 99.1% |
| Streptococcus mutans ATCC10449 | 93.7% | 98.9% |
Table 4
| Group | 2min | 5min |
| Staphylococcus aureus ATCC6538 | 91.6% | 97.5% |
| Escherichia coli 8099 | 92.8% | 97.3% |
| Candida albicans ATCC10231 | 92.3% | 98.2% |
| Streptococcus mutans ATCC10449 | 87.9% | 97.3% |
The present invention is to strain staphylococcus aureus ATCC6538, large intestine bar it can be seen from table 2, table 3 and table 4
Bacterium 8099, Candida albicans ATCC10231, streptococcus mutans ATCC10449 have stronger bacteriostasis, and effect is better than
Artificial saliva described in patent CN105147818A and patent CN1130066A.
Test example 4
Test selects total 135 in January, 2014 in January, 1018 nasopharyngeal carcinoma to receive Co 60 radical radiation therapy patient,
Middle male 72, female 63, average age about 51 years old, the course of disease 1 month to 1 year, Radiotherapy dosimetry 66-70CY/2GY/6-7W；It will suffer from
Person is randomly divided into 8 groups；Test group patient uses the embodiment of the present invention 3, embodiment 6, embodiment 9, embodiment 12,15 and of embodiment
Artificial saliva and usage prepared by embodiment 16；Control group patient uses patent CN105147818A and patent CN1130066A system
Standby artificial saliva；
Meet " nasopharyngeal carcinoma also how the function of parotid breakdown diagnosis of radiotherapy " diagnostic criteria, mouthfeel, pharyngalgia is thirsty to draw
Drink, mouth saliva is sticky, red tongue with yellowish fur or the deep red red no tongue fur of tongue, is slightly dry but is not intended to drink more, can feed stemness food with water；Severe
To need Chang Yinshui, stemness food cannot be fed；
Efficacy determination: 1. complete incidence graph, saliva of buccal cavity secretion increased significantly, and dry is unobvious, and not needing drinking-water can swallow
Stemness food, and without taking medicine still without recurrence in 2 months；2. part is alleviates, xerostomia, dysphagia mitigates, but cannot
Stemness food is swallowed, need to intake can swallow；3. mouthfeel symptom is without alleviation without alleviation；
Treatment results are as follows:
Table 5
| Group | Patient's number | Complete incidence graph | Alleviate part | Without alleviation | Total effective rate |
| Embodiment 3 | 18 | 10 | 6 | 1 | 88.9% |
| Embodiment 6 | 15 | 9 | 5 | 1 | 93.3% |
| Embodiment 9 | 18 | 11 | 6 | 1 | 94.4% |
| Embodiment 12 | 19 | 13 | 4 | 2 | 89.5% |
| Embodiment 15 | 17 | 10 | 6 | 1 | 94.1% |
| Embodiment 16 | 15 | 8 | 7 | 0 | 100% |
| CN105147818A | 17 | 9 | 5 | 3 | 82.4% |
| CN1130066A | 16 | 7 | 5 | 4 | 75.0% |
By test data in table 5 it is found that the present invention has good therapeutic effect for radioactivity xerostomia, and imitate
Fruit is better than control group.
It is important to point out that, above embodiments and test example are only limitted to do further technical solution of the present invention herein
Elaboration and understanding, should not be understood as it is further to technical solution of the present invention limited, what those skilled in the art made
The innovation and creation of non-protruding essential characteristics and marked improvement still fall within protection category of the invention.
Claims (10)
1. a kind of artificial saliva for head and neck neoplasm radiotherapy patient oral complications, which is characterized in that including following weight
The raw material of part: 0.35-0.0.45 parts of NaCl, 0.35-0.45 parts of KCl, CaCl2·2H20.780-0.810 parts of O, NaHPO4·
2H20.75-0.85 parts of O, Na2S·2H20.0045-0.0055 parts of O, 0.8-1.2 parts of Urea, 1000 parts of distilled water.
2. being used for the artificial saliva of head and neck neoplasm radiotherapy patient oral complications as described in claim 1, which is characterized in that packet
Include the raw material of following parts by weight: 0.4 part of NaCl, 0.4 part of KCl, CaCl2·2H20.795 part of O, NaHPO4·2H2O part 0.78
Part, Na2S·2H20.005 part of O, 1 part of Urea, 1000 parts of distilled water.
3. being used for the artificial saliva of head and neck neoplasm radiotherapy patient oral complications as claimed in claim 1 or 2, feature exists
In further including the hydroxymethyl cellulose for having 9-11 parts by weight in the raw material.
4. being used for the artificial saliva of head and neck neoplasm radiotherapy patient oral complications as claimed in claim 1 or 2, feature exists
In further including the NaF for having 0.45-0.55 parts by weight in the raw material.
5. being used for the artificial saliva of head and neck neoplasm radiotherapy patient oral complications as claimed in claim 1 or 2, feature exists
In further including the acetic acid chlorhexidine for having 1-3 parts by weight in the raw material.
6. being used for the artificial saliva of head and neck neoplasm radiotherapy patient oral complications as claimed in claim 1 or 2, feature exists
In the artificial saliva and the drug combination with Yin-nourishing and body fluid promoting, heat-clearing toxin-expelling functions.
7. being used for the artificial saliva of head and neck neoplasm radiotherapy patient oral complications as claimed in claim 6, which is characterized in that institute
Stating medicine material in parts by weight is 140-160 parts of Radix Ophiopogonis, 50-70 parts of honeysuckle, 40-60 parts of dark plum, 10-30 parts of Radix Glycyrrhizae.
8. being used for the artificial saliva of head and neck neoplasm radiotherapy patient oral complications as claimed in claim 1 or 2, feature exists
In the raw material further includes having glycerol, Natural menthol, acesulfame potassium, flavorant.
9. being used for the artificial saliva of head and neck neoplasm radiotherapy patient oral complications as claimed in claim 8, which is characterized in that institute
State glycerol, Natural menthol, acesulfame potassium, flavorant dosage be followed successively by 15-25 parts by weight, 2-4 parts by weight, 9-11 weight
Part, 1-2 parts by weight.
10. application of the artificial saliva of any of claims 1 or 2 in the product that preparation is used for mouth disease.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910506747.7A CN110279710A (en) | 2019-06-12 | 2019-06-12 | A kind of artificial saliva for head and neck neoplasm radiotherapy patient oral complications |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130066A (en) * | 1995-03-01 | 1996-09-04 | 邱生 | Artificial saliva and its preparing method |
| CN101524363A (en) * | 2008-03-06 | 2009-09-09 | 深圳南粤药业有限公司 | Artificial saliva |
| CN105147818A (en) * | 2015-09-29 | 2015-12-16 | 江苏海尔滋生物科技有限公司 | Artificial saliva and preparation method thereof |
| CN106466480A (en) * | 2015-08-20 | 2017-03-01 | 康多宝医疗健康产品（湖南）有限公司 | A kind of artificial saliva preventing and treating radioactivity xerostomia |
| CN108169431A (en) * | 2018-02-26 | 2018-06-15 | 苏州瑞奇丽新材料有限公司 | A kind of artificial saliva and preparation method thereof |
| CN108553355A (en) * | 2018-05-03 | 2018-09-21 | 贵州四季常青药业有限公司 | A kind of compound houttuynin oral bacteriostasis fresh and cool spray and preparation method thereof |
| CN109596778A (en) * | 2018-12-06 | 2019-04-09 | 中国农业科学院烟草研究所 | A kind of artificial saliva and the preparation method and application thereof for buccal cigarette research |
| CN109646452A (en) * | 2018-12-31 | 2019-04-19 | 四川金凯医疗器械有限公司 | Artificial saliva |
-
2019
- 2019-06-12 CN CN201910506747.7A patent/CN110279710A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130066A (en) * | 1995-03-01 | 1996-09-04 | 邱生 | Artificial saliva and its preparing method |
| CN101524363A (en) * | 2008-03-06 | 2009-09-09 | 深圳南粤药业有限公司 | Artificial saliva |
| CN106466480A (en) * | 2015-08-20 | 2017-03-01 | 康多宝医疗健康产品（湖南）有限公司 | A kind of artificial saliva preventing and treating radioactivity xerostomia |
| CN105147818A (en) * | 2015-09-29 | 2015-12-16 | 江苏海尔滋生物科技有限公司 | Artificial saliva and preparation method thereof |
| CN108169431A (en) * | 2018-02-26 | 2018-06-15 | 苏州瑞奇丽新材料有限公司 | A kind of artificial saliva and preparation method thereof |
| CN108553355A (en) * | 2018-05-03 | 2018-09-21 | 贵州四季常青药业有限公司 | A kind of compound houttuynin oral bacteriostasis fresh and cool spray and preparation method thereof |
| CN109596778A (en) * | 2018-12-06 | 2019-04-09 | 中国农业科学院烟草研究所 | A kind of artificial saliva and the preparation method and application thereof for buccal cigarette research |
| CN109646452A (en) * | 2018-12-31 | 2019-04-19 | 四川金凯医疗器械有限公司 | Artificial saliva |
Non-Patent Citations (3)
| Title |
|---|
| 吴海庭等: ""人工唾液在口腔医学研究中的应用"", 《遵义医学院学报》 * |
| 方溢云: ""人工唾液应用于鼻咽癌放疗后放射性龋的预防研究"", 《黑龙江医学》 * |
| 林家成等: ""金银花甘草人工唾液防龋的实验研究"", 《中华口腔医学研究杂志（电子版）》 * |
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Address after: No.1 Changqing Road, Shangba Industrial Park, Daozhen Autonomous County, Zunyi City, Guizhou Province Applicant after: GUIZHOU EVERGREEN PHARMACEUTICAL Co.,Ltd. Address before: 563500 Guizhou city in Zunyi Province, Daozhen yilao and Miao Autonomous County Xintian Village Center BA Xiang Group Applicant before: GUIZHOU EVERGREEN PHARMACEUTICAL Co.,Ltd. |
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Application publication date: 20190927 |