CN109568546A - A kind of preparation method of the Chinese medicine composition for treating rheumatoid arthritis and its patch - Google Patents
A kind of preparation method of the Chinese medicine composition for treating rheumatoid arthritis and its patch Download PDFInfo
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- CN109568546A CN109568546A CN201910102598.8A CN201910102598A CN109568546A CN 109568546 A CN109568546 A CN 109568546A CN 201910102598 A CN201910102598 A CN 201910102598A CN 109568546 A CN109568546 A CN 109568546A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention relates to the preparation methods of a kind of Chinese medicine composition for treating rheumatoid arthritis and its patch.Chinese medicine composition includes the raw material of following parts by weight: 20 ~ 35 parts of wide leaf nettle, 15 ~ 30 parts of turmeric, 12 ~ 25 parts of caulis sinomenii, 10 ~ 25 parts of Rhizoma Chuanxiong, 3 ~ 10 parts of pawpaw, 3 ~ 10 parts of Radix Paeoniae Alba, 3 ~ 10 parts of schizonepeta.Patch the preparation method comprises the following steps: the requirement of the parts by weight by Chinese medicine composition, weighs the raw materials such as wide leaf nettle, turmeric, caulis sinomenii, Rhizoma Chuanxiong, pawpaw, Radix Paeoniae Alba and schizonepeta, crush, with 95% ethyl alcohol heating and refluxing extraction 2h, solid-liquid ratio 1g:4ml, 80 DEG C of temperature, extracting solution filtering, is concentrated to give medicinal extract.(2) said medicine medicinal extract is injected into drug storage layer, is 1.05 by the relative density of drug storage layer heat drying to medicinal extract, successively pressure-sensitive adhesive layer, drug storage layer and protective layer is bonded together, to obtain patch.The present invention is the safe and effective drug for treating and preventing rheumatoid arthritis.
Description
Technical field
The present invention relates to the preparation methods of a kind of Chinese medicine composition for treating rheumatoid arthritis and its patch.
Background technique
Rheumatoid arthritis is the autoimmune disease of a kind of chronic, progressive, invasion, is had progressive and repeatedly
The characteristics of breaking-out.Rheumatoid arthritis has morbidity in the whole country, and the illness rate in China is 0.3 ~ 0.4%, clinical onset
It shows as by for a long time pain, arthroncus and function reduction.Clinical treatment rheumatoid arthritis master sugar to be used at present
Mostly there is biggish toxic side effect in cortin, non-steroidal anti-inflammatory drugs, biological agent, and price is relatively high, and Chinese medicine and in
Medicine preparation toxic side effect is relatively small, moderate, there is greater advantage, therefore from natural resources of Chinese medicinal materials, it is small to develop toxic side effect
Resisting rheumatoid arthritis drug be necessary.
Summary of the invention
Toxic side effect existing for chemicals for treatment rheumatoid arthritis, and the problem that price is relatively high, this
Invention provides the preparation method of a kind of Chinese medicine composition for treating rheumatoid arthritis and its patch.
The technical solution used to solve the technical problems of the present invention is that a kind of Chinese traditional medicine composition for treating rheumatoid arthritis
Object, the raw material including following parts by weight: 20 ~ 35 parts of wide leaf nettle, 15 ~ 30 parts of turmeric, 12 ~ 25 parts of caulis sinomenii, Rhizoma Chuanxiong 10 ~ 25
Part, 3 ~ 10 parts of pawpaw, 3 ~ 10 parts of Radix Paeoniae Alba, 3 ~ 10 parts of schizonepeta.
Chinese medicine composition of the invention, the raw material components of preferably following parts by weight: 20 parts of wide leaf nettle, 15 parts of turmeric, blueness
15 parts of wind rattan, 10 parts of Rhizoma Chuanxiong, 3 parts of pawpaw, 3 parts of Radix Paeoniae Alba, 3 parts of schizonepeta.
Chinese medicine composition of the invention, the raw material components of further preferred following parts by weight: 30 parts of wide leaf nettle, turmeric 20
Part, 20 parts of caulis sinomenii, 15 parts of Rhizoma Chuanxiong, 6 parts of pawpaw, 6 parts of Radix Paeoniae Alba, 6 parts of schizonepeta.
Chinese medicine composition of the invention, the raw material components of further preferably following parts by weight: 35 parts of wide leaf nettle, 30 parts of turmeric,
25 parts of caulis sinomenii, 25 parts of Rhizoma Chuanxiong, 10 parts of pawpaw, 10 parts of Radix Paeoniae Alba, 10 parts of schizonepeta.
A kind of preparation method of the patch of Chinese medicine composition for treating rheumatoid arthritis of the present invention, step
Are as follows:
(1) weigh 20 ~ 35 parts of wide leaf nettle, 15 ~ 30 parts of turmeric, 12 ~ 25 parts of caulis sinomenii, 10 ~ 25 parts of Rhizoma Chuanxiong, 3 ~ 10 parts of pawpaw,
3 ~ 10 parts of Radix Paeoniae Alba, 3 ~ 10 parts of schizonepeta crush, and with 95% ethyl alcohol heating and refluxing extraction 2h, solid-liquid ratio 1g:4ml, is mentioned by 80 DEG C of temperature
It takes liquid to filter, is concentrated to give medicinal extract.
(2) said medicine medicinal extract is injected into drug storage layer, is 1.05 by the relative density of drug storage layer heat drying to medicinal extract, according to
It is secondary that pressure-sensitive adhesive layer, drug storage layer and protective layer are bonded together, to obtain patch.
The effect of above-mentioned each raw medicinal material, is as follows:
Wide leaf nettle: have dispelling wind and relieving convulsion, help digestion defaecation the effect of.Cure mainly rheumatic arthritis, postpartum exhausting, child convulsion is small
Youngster's sequela of paralysis, hypertension, indigestion etc..
Turmeric: blood-breaking, promoting the circulation of qi, promoting menstruation, analgesic.Control trusted subordinate's feeling of fullness distending pain, brachialgia, abdominal mass, women's blood stasis, the postpartum stasis of blood
Stop abdominal pain, injury from falling down, carbuncle swells.
Caulis sinomenii: wind-damp dispelling, degrading the channel, diuresis.Rheumatic arthralgia is cured mainly, itch is benumbed in arthroncus.
Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.Pungent scattered temperature is logical, can activating microcirculation and removing stasis medicinal and promoting qi circulation and relieving pain, for " the gas in blood
Medicine.
Pawpaw: relaxing tendons and activating collaterals, stomach function regulating dampness elimination.Cure mainly rheumatic arthralgia, vague aching of limbs, muscle arteries and veins contraction, spasm of vomiting and diarrhoea, beriberi liquor
It is swollen.
Radix Paeoniae Alba: middle analgesic, contagious yin are delayed in nourishing blood and liver.Control chest and abdomen pain over the hypochondriac region, diarrhea dysentery abdominal pain, spontaneous sweating, the deficiency of Yin
Fever, irregular menstruation, metrorrhagia and metrostaxis, leukorrhagia.
Schizonepeta: expelling pathogenic wind from the body surface, and promoting eruption disappears sore, hemostasis.Pungent air-dispersing is fragrant, is longer than and delivers relieve heat.
Medical pressure-sensing glue-line of the present invention is polyolefin hot-melt adhesive, acrylate polymer, rubber polymerization
One of object or vinylic-ether polymer；The protective layer selects aluminium foil, polyethylene composite film, separate paper, vinyl acetate
One of copolymer, acrylate pressure sensitive adhesive, silicon rubber or polyethylene glycol, drug storage layer choosing compression cotton, sponge or the PU
Seepage-proofing ring is made, the recess of drug extract injection seepage-proofing ring is facilitated into drug storage, while preventing drug extract from melting extravasation.
The invention has the advantages that patch treatment rheumatoid arthritis total effective rate of the present invention is 91.3%,
It is the safe and effective drug for treating and preventing rheumatoid arthritis, there is good clinical expansion meaning.
Specific embodiment
Below with reference to embodiment, the invention will be further described
Embodiment 1
A kind of Traditional Chinese medicine composition patch for treating rheumatoid arthritis, the parts by weight of raw materials of traditional Chinese medicine composition are as follows: wide leaf nettle
Numb 20 parts, 15 parts of turmeric, 15 parts of caulis sinomenii, 10 parts of Rhizoma Chuanxiong, 3 parts of pawpaw, 3 parts of Radix Paeoniae Alba, 3 parts of schizonepeta.Preparation step are as follows:
(1) 20 parts of wide leaf nettle, 15 parts of turmeric, 15 parts of caulis sinomenii, 10 parts of Rhizoma Chuanxiong, 3 parts of pawpaw, 3 parts of Radix Paeoniae Alba, 3 parts of schizonepeta are weighed,
It crushes, with 95% ethyl alcohol heating and refluxing extraction 2h, solid-liquid ratio 1g: 4ml, 80 DEG C of temperature, extracting solution filtering is concentrated to give medicinal extract.
(2) by the recess of said medicine medicinal extract injection compression cotton seepage-proofing ring, the relative density of heat drying to medicinal extract is
1.05, it successively will be with pressure-sensitive adhesive layer made of polyolefin hot-melt adhesive, made of compression cotton seepage-proofing ring and drug extract
It drug storage layer and is bonded together with protective layer made of polyethylene composite film, to obtain patch.
Embodiment 2
A kind of Traditional Chinese medicine composition patch for treating rheumatoid arthritis, the parts by weight of raw materials of traditional Chinese medicine composition are as follows: wide leaf nettle
Numb 30 parts, 20 parts of turmeric, 20 parts of caulis sinomenii, 15 parts of Rhizoma Chuanxiong, 6 parts of pawpaw, 6 parts of Radix Paeoniae Alba, 6 parts of schizonepeta.Preparation step are as follows:
(1) 30 parts of wide leaf nettle, 20 parts of turmeric, 20 parts of caulis sinomenii, 15 parts of Rhizoma Chuanxiong, 6 parts of pawpaw, 6 parts of Radix Paeoniae Alba, 6 parts of schizonepeta are weighed,
It crushes, with 95% ethyl alcohol heating and refluxing extraction 2h, solid-liquid ratio 1g: 4ml, 80 DEG C of temperature, extracting solution filtering is concentrated to give medicinal extract.
(2) by the recess of said medicine medicinal extract injection compression cotton seepage-proofing ring, the relative density of heat drying to medicinal extract is
1.05, it successively will be with pressure-sensitive adhesive layer made of polyolefin hot-melt adhesive, made of compression cotton seepage-proofing ring and drug extract
It drug storage layer and is bonded together with protective layer made of polyethylene composite film, to obtain patch.
Embodiment 3
A kind of Traditional Chinese medicine composition patch for treating rheumatoid arthritis, the parts by weight of raw materials of traditional Chinese medicine composition are as follows: wide leaf nettle
Numb 35 parts, 30 parts of turmeric, 25 parts of caulis sinomenii, 25 parts of Rhizoma Chuanxiong, 10 parts of pawpaw, 10 parts of Radix Paeoniae Alba, 10 parts of schizonepeta, preparation step are as follows:
(1) 35 parts of wide leaf nettle, 30 parts of turmeric, 25 parts of caulis sinomenii, 25 parts of Rhizoma Chuanxiong, 10 parts of pawpaw, 10 parts of Radix Paeoniae Alba, schizonepeta 10 are weighed
Part, it crushes, with 95% ethyl alcohol heating and refluxing extraction 2h, solid-liquid ratio 1g: 4ml, 80 DEG C of temperature, extracting solution filtering is concentrated to give leaching
Cream.
(2) by the recess of said medicine medicinal extract injection compression cotton seepage-proofing ring, the relative density of heat drying to medicinal extract is
1.05, it successively will be with pressure-sensitive adhesive layer made of polyolefin hot-melt adhesive, made of compression cotton seepage-proofing ring and drug extract
It drug storage layer and is bonded together with protective layer made of polyethylene composite film, to obtain patch.
Situation statistics is improved to the state of an illness of patient with rheumatoid arthritis:
1. case choose: clinically select 40 suffer from rheumatoid arthritis patients, the age 40 ~ 70 years old, male 10, women
30.
2. experimental method: 40 patient's continuous use controlling using the method for the present invention preparation with rheumatoid arthritis
The patch of rheumatoid arthritis is treated, pastes 8 ~ 12 hours within one day, observes therapeutic effect.
3. clinical data is shown, 35 patient pains are significantly alleviated, and 3 patient pains obtain slight relief,
Invalid 2.
4. result: being shown according to above data, it is 91.3% that the present invention, which treats rheumatoid arthritis total effective rate,.
So a kind of Chinese medicine composition for treating rheumatoid arthritis of the invention and its patch are to treat and prevent class
The safe and effective drug of rheumatic arthritis has good clinical expansion meaning.
Claims (7)
1. a kind of Chinese medicine composition for treating rheumatoid arthritis, which is characterized in that the raw material including following parts by weight: wide leaf
20 ~ 35 parts of nettle, 15 ~ 30 parts of turmeric, 12 ~ 25 parts of caulis sinomenii, 10 ~ 25 parts of Rhizoma Chuanxiong, 3 ~ 10 parts of pawpaw, 3 ~ 10 parts of Radix Paeoniae Alba, schizonepeta 3
~ 10 parts.
2. a kind of Chinese medicine composition for treating rheumatoid arthritis according to claim 1, which is characterized in that including with
The raw material of lower parts by weight: 20 parts of wide leaf nettle, 15 parts of turmeric, 15 parts of caulis sinomenii, 10 parts of Rhizoma Chuanxiong, 3 parts of pawpaw, 3 parts of Radix Paeoniae Alba, schizonepeta
3 parts.
3. a kind of Chinese medicine composition for treating rheumatoid arthritis according to claim 1, which is characterized in that including with
The raw material of lower parts by weight: 30 parts of wide leaf nettle, 20 parts of turmeric, 20 parts of caulis sinomenii, 15 parts of Rhizoma Chuanxiong, 6 parts of pawpaw, 6 parts of Radix Paeoniae Alba, schizonepeta
6 parts.
4. a kind of Chinese medicine composition for treating rheumatoid arthritis according to claim 1, which is characterized in that including with
The raw material of lower parts by weight: 35 parts of wide leaf nettle, 30 parts of turmeric, 25 parts of caulis sinomenii, 25 parts of Rhizoma Chuanxiong, 10 parts of pawpaw, 10 parts of Radix Paeoniae Alba, chaste tree
10 parts of mustard.
5. a kind of preparation method of the patch of Chinese medicine composition for treating rheumatoid arthritis according to claim 1,
It the steps include:
(1) weigh 20 ~ 35 parts of wide leaf nettle, 15 ~ 30 parts of turmeric, 12 ~ 25 parts of caulis sinomenii, 10 ~ 25 parts of Rhizoma Chuanxiong, 3 ~ 10 parts of pawpaw,
3 ~ 10 parts of Radix Paeoniae Alba, 3 ~ 10 parts of schizonepeta crush, and with 95% ethyl alcohol heating and refluxing extraction 2h, solid-liquid ratio 1g:4ml, is mentioned by 80 DEG C of temperature
It takes liquid to filter, is concentrated to give medicinal extract；
(2) said medicine medicinal extract is injected into drug storage layer, is 1.05 by the relative density of drug storage layer heat drying to medicinal extract, successively will
Pressure-sensitive adhesive layer, drug storage layer and protective layer are bonded together, to obtain patch.
6. a kind of preparation method of the patch of Chinese medicine composition for treating rheumatoid arthritis according to claim 5,
It is characterized in that, the medical pressure-sensing glue-line be polyolefin hot-melt adhesive, acrylate polymer, rubber polymer or
One of vinylic-ether polymer；
The protective layer selects aluminium foil, polyethylene composite film, separate paper, acetate ethylene copolymer, acrylate pressure sensitive adhesive, silicon rubber
One of glue or polyethylene glycol.
7. a kind of preparation method of the patch of Chinese medicine composition for treating rheumatoid arthritis according to claim 5,
It is characterized in that, the drug storage layer is equipped with recess.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910102598.8A CN109568546A (en) | 2019-02-01 | 2019-02-01 | A kind of preparation method of the Chinese medicine composition for treating rheumatoid arthritis and its patch |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910102598.8A CN109568546A (en) | 2019-02-01 | 2019-02-01 | A kind of preparation method of the Chinese medicine composition for treating rheumatoid arthritis and its patch |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1778383A (en) * | 2004-11-24 | 2006-05-31 | 香港赛马会中药研究院有限公司 | Herbal medical preparation for the treatment of arthritis |
| CN101766695A (en) * | 2009-01-06 | 2010-07-07 | 天津奥克莱斯生物技术有限公司 | Point eye mask and preparation method and application thereof |
| CN108619485A (en) * | 2018-07-24 | 2018-10-09 | 张孝合 | A kind of compound navel patch and preparation method thereof for treating prostatic disorders |
-
2019
- 2019-02-01 CN CN201910102598.8A patent/CN109568546A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1778383A (en) * | 2004-11-24 | 2006-05-31 | 香港赛马会中药研究院有限公司 | Herbal medical preparation for the treatment of arthritis |
| CN101766695A (en) * | 2009-01-06 | 2010-07-07 | 天津奥克莱斯生物技术有限公司 | Point eye mask and preparation method and application thereof |
| CN108619485A (en) * | 2018-07-24 | 2018-10-09 | 张孝合 | A kind of compound navel patch and preparation method thereof for treating prostatic disorders |
Non-Patent Citations (4)
| Title |
|---|
| 唐玲等: "宽叶荨麻抗类风湿性关节炎的研究", 《时珍国医国药》 * |
| 李德平等: "广安门医院活动期类风湿关节炎中医处方规律分析", 《中国实验方剂学杂志》 * |
| 陈大舜等: "《最好的中医名著公开课 名师解读历代名医临床必读医论》", 31 August 2014 * |
| 陈琼: "《中药制剂技术》", 31 August 2009 * |
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