CN109568462A - A kind of application of Chinese medicine composition in treatment acne - Google Patents
A kind of application of Chinese medicine composition in treatment acne Download PDFInfo
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- CN109568462A CN109568462A CN201910012113.6A CN201910012113A CN109568462A CN 109568462 A CN109568462 A CN 109568462A CN 201910012113 A CN201910012113 A CN 201910012113A CN 109568462 A CN109568462 A CN 109568462A
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- 206010000496 acne Diseases 0.000 title claims abstract description 54
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 52
- 239000000203 mixture Substances 0.000 title claims abstract description 35
- 229940079593 drug Drugs 0.000 claims abstract description 36
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Classifications
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention belongs to field of medicaments, and in particular to a kind of application of Chinese medicine composition in treatment acne.Chinese medicine composition of the invention can be used for treating acne.It includes: 80 parts by weight of rhizoma atractylodis, 80 parts by weight of dried orange peel, 80 parts by weight of Cortex Magnoliae Officinalis, 120 parts by weight of the root of Dahurain angelica, 120 parts by weight of Poria cocos, 120 parts by weight of the shell of areca nut, 80 parts by weight of dried pinellia, 10 parts by weight of extract of licorice root, 0.8 parts by volume of patchouli oil, 0.4 parts by volume of perilla leaf oil.Have effects that expelling superficial pathogens and clearing away summer-heat, dampness elimination and in.The drug and fragrant sand stomach Siberian cocklebur ball drug combination of composition preparation of the invention, fragrant sand stomach Siberian cocklebur ball have the effect of spleen, relieving QI stagnancy in the stomach are transported in clearing damp, enhance clearing damp effect after the two joint, and play the role of coordinating intestines and stomach, can improve the acne caused by diet problem.Nine rhubarb balls are further increased, the acne that eating and drinking without temperance and gastrointestinal retention cause can be improved.
Description
Technical field
The invention belongs to field of medicaments, and in particular to a kind of application of Chinese medicine composition in treatment acne.
Background technique
Acne (acne) is the common disease of dermatology, frequently-occurring disease, especially in puberty men and women's disease incidence highest.It is hair follicle
The chronic inflammation of sebaceous glands, takes place mostly in face and thoracic dorsal etc., show as blackhead, inflamed papules, secondary pustule or
Tubercle, tumour etc., few patients even form recess or hyperplastic scar, seriously affect the quality of life of patient.Its machine of falling ill
Reason is it is generally acknowledged that be related to: (1) pilosebaceous duct dyskeratosis；(2) microbial action mainly has with propionibacterium acnes
It closes；(3) regulation of the androgen to sebaceous glands；(4) Inflammatory Lesions.This disease belongs to Chinese medicine " lung-wind comedo " scope.Chinese medicine thinks its hair
Disease is mostly because of eating and drinking without temperance, and overfeeding delicious food savoury, lung stomach is damp and hot, feels ailment said due to cold or exposure again and causes.It is high according to the disease puberty disease incidence, and female
Property the patients with acne state of an illness mostly the characteristics of aggravating before menstruation the moon, propose that this disease is that mutually fire Kang Sheng is this, it is multiple because of the pungent delicious food of overfeeding, wine
At damp and hot, qi and blood stasis is fallen ill in skin passages through which vital energy circulates for mark.
It is recorded in " surgery opens profound ": " causing fecula thorn, cover by damp and hot ".Traditional Chinese medicine thinks that the human diet of fat meat and fine grain does not save, often
Pungent greasy product are eaten, raw humidogene heat knot is in stomach, and because of the lung and the large intestine being interior-exteriorly related, therefore damp and hot upper steaming causes lung stomach blood in lung stomach
Heat, it is strongly fragrant to give birth to acne in skin.
Granted patent CN 104667048A discloses a kind of Chinese medicine for treating puberty acne vulgaris, belongs to traditional Chinese medicine
Field.The raw material composition of effective component is made are as follows: loguat leaf, Radix Rehmanniae, dittany bark, the root bark of white mulberry, cortex moutan, oldenlandia diffusa, pellet
Ginseng, radix scrophulariae, radix scutellariae, the coptis, chrysanthemum, Prunella vulgaris, SEMEN COICIS, smilax, cacumen biotae, tribulus terrestris, the root of Dahurain angelica, Radix Glycyrrhizae.The invention
Drug heat-clearing effect is stronger, and patient has the side effect that times of defecation increases when taking.
Therefore a kind of Chinese medicine composition for having clearing damp effect is developed in the application of the drug of preparation treatment acne, and is provided
The usage of the combination therapies, with clearing damp and coordinating intestines and stomach, to effectively treat acne.
Summary of the invention
In view of this, can be applied to preparation treatment acne the purpose of the present invention is to provide a kind of Chinese medicine composition
Drug.
To achieve the above object, the technical solution of the present invention is as follows:
A kind of application of Chinese medicine composition in the drug of preparation treatment acne, which is characterized in that the Chinese medicine composition
Be formulated it is as follows: 80 parts by weight of rhizoma atractylodis, 80 parts by weight of dried orange peel, 80 parts by weight of Cortex Magnoliae Officinalis, 120 parts by weight of the root of Dahurain angelica, 120 parts by weight of Poria cocos,
120 parts by weight of the shell of areca nut, 80 parts by weight of dried pinellia, 10 parts by weight of extract of licorice root, 0.8 parts by volume of patchouli oil and perilla leaf oil
0.4 parts by volume.
Such as without special specified, the unit of weight of the parts by weight in the traditional chinese medicine composition of the invention formula and the volume list of parts by volume
Position is matching relationship.That is: when the unit of weight of parts by weight is Kg, the volume unit of parts by volume is L；When the weight list of parts by weight
When position is g, the volume unit of parts by volume is mL.The preferred ginger Cortex Magnoliae Officinalis of Cortex Magnoliae Officinalis mentioned by the present invention.
The preparation method of Chinese medicine composition of the invention includes the following steps: the Cortex Magnoliae Officinalis alcohol reflux for taking formula ratio
It extracts, obtains the ethanol extract of Cortex Magnoliae Officinalis；The distillation of the rhizoma atractylodis of formula ratio, the dried orange peel and the root of Dahurain angelica water as medium is mentioned
It takes, must distill and extract mixed liquor；The shell of areca nut water of the formula ratio is decocted and filtered, shell of areca nut decoction liquor is obtained；It will be described
After the Poria cocos of formula ratio is boiled with water as medium, and 70-90 DEG C is cooled to sufficiently infiltrating and filtering, obtain Poria cocos temperature immersion liquid；It takes
The dried pinellia of formula ratio is sufficiently impregnated with aqueous medium, obtains tuber of pinellia soak；And it takes and is equivalent to 0.06-0.1 times of dried pinellia weight ratio
Rhizoma zingiberis, decoct again, obtain the tuber of pinellia and rhizoma zingiberis obtains mixed soaking solution.Mixed liquor, big abdomen are extracted into the ethanol extract, distillation
Skin decoction liquor, the immersion liquid of Poria cocos temperature and the tuber of pinellia and rhizoma zingiberis obtain mixed soaking solution and are sufficiently mixed, and being concentrated into density is 1.10-1.20
Paste, and the extract of licorice root of formula ratio is added, the paste is mixed with the extract of licorice root and recycled ethyl alcohol,
Patchouli oil, the mixed liquor of perilla leaf oil and the aqueous medium of surplus of auxiliary material Tween 80 and the formula ratio is added, uses hydroxide
Sodium adjusts pH value to 5.8-6.2, obtains the Chinese medicine composition.
Whelk, i.e. acne, acne.It is recorded in " surgery opens profound ": " causing fecula thorn, cover by damp and hot ".Traditional Chinese medicine thinks,
The human diet of fat meat and fine grain does not save, and often eats pungent greasy product, and raw humidogene heat knot is in stomach, because of the lung and the large intestine being interior-exteriorly related, therefore it is damp and hot on
It steams and causes lung stomach blood-head in lung stomach, it is strongly fragrant to give birth to acne in skin.Chinese medicine composition of the invention has inducing diaphoresis dampness elimination, and qi-regulating is in
The effect of, can coordinating intestines and stomach, improve the acne caused by gastro-intestinal problems.
Preferably, the drug of the treatment acne can be any pharmaceutically acceptable dosage form.As liquid, capsule, tablet,
Grain, pill etc..
Preferably, the drug of the preparation treatment acne further includes pharmaceutical acceptable carrier and/or auxiliary agent.
Preferably, the drug of the preparation treatment acne further includes other active components.
Drug combination (drug combination) refers to two or more used to reach therapeutic purposes
Drug is applied simultaneously or successively.
Influencing each other for internal or external drug often occurs for drug combination.
Drug influences each other referred to as incompatibility (incompatibility) in vitro, refers to drug being blended in one
The physically or chemically reaction occurred is acted, is particularly susceptible generation when several drugs are combined intravenous drip.Drug is sent out in vivo
Raw influence each other referred to as interacts (interaction), occurs mainly in some links in terms of pharmacokinetics and pharmacodynamics.
No matter occur there are two types of final variations in terms of that only: being known as acting synergistically first is that enhancing original effect
(synergism), second is that making original effect decrease, referred to as antagonism (antagonism).
For therapeutic effect of the drug for acne for enhancing the treatment acne that Chinese medicine composition of the invention is used to prepare, make
For the drug and fragrant sand stomach Siberian cocklebur ball drug combination of the treatment acne that preferred scheme, above-mentioned Chinese medicine composition are used to prepare.
Wherein fragrant sand stomach Siberian cocklebur ball has played synergistic effect.Wherein the drug of Chinese medicine composition preparation of the invention can inducing diaphoresis dispel
Heat, dampness elimination and in, fragrant sand stomach Siberian cocklebur ball can clearing damp transport spleen, relieving QI stagnancy in the stomach, the two combination reaches enhancing clearing damp effect, coordinating intestines and stomach
Effect can improve the acne caused by diet problem.
It is further preferred that the drug for the treatment acne that above-mentioned Chinese medicine composition is used to prepare and fragrant sand stomach Siberian cocklebur ball, nine systems
Rhei Pill drug combination.Wherein rheum officinale, which has, rushes down lower promoting effect, can improve the acne that eating and drinking without temperance and gastrointestinal retention cause.
The beneficial effects of the present invention are:
1) Chinese medicine composition provided by the invention can be used for preparing the drug for the treatment of acne, be used to treat acne, act on
Mildly, toxic side effect is small.
2) drug and fragrant sand stomach Siberian cocklebur ball drug combination of Chinese medicine composition preparation provided by the invention, the two combination reach increasing
The effect of strong clearing damp effect, coordinating intestines and stomach, can improve the acne caused by diet problem.
3) drug and fragrant sand stomach Siberian cocklebur ball, nine rhubarb ball drug combinations of Chinese medicine composition preparation provided by the invention, energy
Improve the acne that eating and drinking without temperance and gastrointestinal retention cause.
Specific embodiment
It detailed description of a preferred embodiment of the present invention will be given below.The reality of actual conditions is not specified in preferred embodiment
Proved recipe method, usually according to normal condition, illustrated embodiment are but not to be to preferably be illustrated to the contents of the present invention
The contents of the present invention are only limitted to illustrated embodiment.So those skilled in the art are according to foregoing invention content to embodiment party
Case carries out nonessential modifications and adaptations, still falls within protection scope of the present invention.
Embodiment 1
Rhizoma atractylodis 80g, dried orange peel 80g, Cortex Magnoliae Officinalis (ginger system) 80g, root of Dahurain angelica 120g, Poria cocos 120g, shell of areca nut 120g, dried pinellia 80g,
Extract of licorice root 10g, patchouli oil 0.8ml, perilla leaf oil 0.4ml.
It takes the Cortex Magnoliae Officinalis of formula ratio to be extracted with alcohol reflux, obtains the ethanol extract of Cortex Magnoliae Officinalis；By the described grey of formula ratio
Art, the dried orange peel and the root of Dahurain angelica are distilled with water as medium to be extracted, and must be distilled and be extracted mixed liquor；By the shell of areca nut of the formula ratio
It is decocted and is filtered with water, obtain shell of areca nut decoction liquor；After the Poria cocos of the formula ratio is boiled with water as medium, and it is cooled to 70-
90 DEG C, to sufficiently infiltrating and filtering, obtain Poria cocos temperature immersion liquid；It takes the dried pinellia of formula ratio sufficiently to be impregnated with aqueous medium, obtains tuber of pinellia immersion
Liquid；And the rhizoma zingiberis for being equivalent to 0.06-0.1 times of dried pinellia weight ratio is taken, it decocts again, obtains the tuber of pinellia and rhizoma zingiberis obtains mixed soaking solution；
Mixed liquor, shell of areca nut decoction liquor, the immersion liquid of Poria cocos temperature and the tuber of pinellia are extracted into the ethanol extract, distillation and done
Ginger obtains mixed soaking solution and is sufficiently mixed, and is concentrated into density and is the paste of 1.10-1.20, and the Radix Glycyrrhizae leaching of formula ratio is added
The paste is mixed with the extract of licorice root and is recycled ethyl alcohol, the wide leaves of pulse plants of auxiliary material Tween 80 and the formula ratio is added by cream
The mixed liquor of sesame oil, perilla leaf oil adds water to 1025ml, adjusts pH to 5.8-6.2, stands, filters to obtain clear solution, sterilizes,
It is filling to obtain solution.
2 clinical case of embodiment
One, clinical data
1.1, all cases are all from March, 2017 to 2017 Fuling District institute of traditional Chinese medicine, the Chongqing City Nian9Yue Dermatology Outpatient Department diseases
People.This group 50 patient age 15-31 years old, 22 years old average, the course of disease was most 3 months short, longest 7 years, 3.5 years average.It is divided into three groups,
The patient of experimental group 1 is with constipation, totally 12 people；Remaining 38 people is randomly divided into two groups, is experimental group 2 and control group, each 19 people.
1.2, diagnostic criteria debates " clinical dermatology " standard of chief editor referring to Zhao, specifically: face, forehead, cheek and
There is conical papule consistent with hair follicle in nose cheek and chest and back.It can be divided again according to the state of an illness: 1. acne vulgaris, 2. papular Cuo
Sore, 3. acne pustulosa, 4. sclerancne, 5. cystic acne, 6. acne atrophica.
1.3, treatment method:
Treatment group is treated using traditional Chinese medicine for oral administration, prescription:
1. solution made from embodiment 1.It is oral, a 10ml, 2 times a day.
2. fragrant sand stomach Siberian cocklebur ball takes orally, a 6g, 2 times a day.
3. nine rhubarb balls take orally, a 6g, 1 times a day.
30 days as a treatment course.2. 3. 1. experimental group 1 is according to dosage taken, 1. 2. experimental group 2 is according to dosage taken, control group clothes
Use minocycline.Then the skin lesion quantity of three groups of patient affected part acne, papule, warts, tubercle, tumour is observed.
1.4, criterion of therapeutical effect: recovery from illness, face, chest, back papule completely disappear；It is effective: face, chest, the big portion of pimpling, back institute
Point or partial disappearance, stay a small amount of papule and pigmentation.Invalid: papule number and form increase without significant change, or instead.
Two, clinical effectiveness
2.1 experimental group
As a result:
| Group | n | Recovery from illness | Effectively | In vain | Total effective rate % |
| Experimental group 1 | 12 | 2 | 9 | 1 | 91.7 |
| Experimental group 2 | 19 | 7 | 10 | 2 | 89.5 |
| Control group | 19 | 6 | 7 | 6 | 68.4 |
Conclusion: the drug of Chinese medicine composition preparation of the invention is to 30 days effective percentage of acne in conjunction with fragrant sand stomach Siberian cocklebur ball
89.5%.
The drug of Chinese medicine composition preparation of the invention, in conjunction with fragrant sand stomach Siberian cocklebur ball and nine rhubarb balls, to constipation
It is 91.7% that homeliness type acne 30 days efficient.
30 days total effective rates of control group are 68.4%.
The drug therapy acne of Chinese medicine composition preparation of the invention is effectively, reliably, uneasy to recur, without apparent bad anti-
It answers.And control group (Western medicine minocycline), it is easy to recur after the edible maror of discovery although part is effectively, and have secondary work
With.
Finally, it is stated that the above examples are only used to illustrate the technical scheme of the present invention and are not limiting, although referring to compared with
Good embodiment describes the invention in detail, those skilled in the art should understand that, it can be to skill of the invention
Art scheme is modified or replaced equivalently, and without departing from the objective and range of technical solution of the present invention, should all be covered at this
In the scope of the claims of invention.
Claims (7)
1. a kind of application of Chinese medicine composition in the drug of preparation treatment acne, which is characterized in that the Chinese medicine composition is matched
Side it is as follows: 80 parts by weight of rhizoma atractylodis, 80 parts by weight of dried orange peel, 80 parts by weight of Cortex Magnoliae Officinalis, 120 parts by weight of the root of Dahurain angelica, 120 parts by weight of Poria cocos, greatly
120 parts by weight of abdomen skin, 80 parts by weight of dried pinellia, 10 parts by weight of extract of licorice root, 0.8 parts by volume of patchouli oil and perilla leaf oil 0.4
Parts by volume.
2. application of the Chinese medicine composition as described in claim 1 in the drug of preparation treatment acne, which is characterized in that in described
The preparation method of drug composition includes the following steps: to take the Cortex Magnoliae Officinalis of formula ratio to be extracted with alcohol reflux, obtains the ethyl alcohol of Cortex Magnoliae Officinalis
Extracting solution；The rhizoma atractylodis, the dried orange peel and the root of Dahurain angelica of formula ratio are distilled with water as medium and are extracted, extraction mixing must be distilled
Liquid；The shell of areca nut water of the formula ratio is decocted and filtered, shell of areca nut decoction liquor is obtained；The Poria cocos water of the formula ratio is made
After medium boils, and 70-90 DEG C is cooled to sufficiently infiltrating and filtering, obtain Poria cocos temperature immersion liquid；Take the dried pinellia water of formula ratio
Medium sufficiently impregnates, and obtains tuber of pinellia soak；And the rhizoma zingiberis for being equivalent to 0.06-0.1 times of dried pinellia weight ratio is taken, it decocts, obtains again
The tuber of pinellia and rhizoma zingiberis obtain mixed soaking solution；
Mixed liquor, shell of areca nut decoction liquor, the immersion liquid of Poria cocos temperature and the tuber of pinellia are extracted into the ethanol extract, distillation and rhizoma zingiberis obtains
Mixed soaking solution is sufficiently mixed, and is concentrated into density and is the paste of 1.10-1.20, and the extract of licorice root of formula ratio is added,
The paste is mixed with the extract of licorice root and recycled ethyl alcohol, the Pogostemon cablin of auxiliary material Tween 80 and the formula ratio is added
The aqueous medium of oil, the mixed liquor of perilla leaf oil and surplus adjusts pH value to 5.8-6.2 with sodium hydroxide, obtains the Chinese traditional medicine composition
Object.
3. application of the Chinese medicine composition as claimed in claim 1 or 2 in the drug of preparation treatment acne, which is characterized in that institute
The drug for stating treatment acne can be any pharmaceutically acceptable dosage form.
4. application of the Chinese medicine composition as claimed in claim 1 or 2 in the drug of preparation treatment acne, which is characterized in that institute
The drug for stating preparation treatment acne further includes pharmaceutical acceptable carrier and/or auxiliary agent.
5. application of the Chinese medicine composition as claimed in claim 1 or 2 in the drug of preparation treatment acne, which is characterized in that institute
The drug for stating preparation treatment acne further includes other active components.
6. application of the Chinese medicine composition as claimed in claim 1 or 2 in the drug of preparation treatment acne, which is characterized in that institute
State the drug and fragrant sand stomach Siberian cocklebur ball drug combination for the treatment of acne.
7. application of the Chinese medicine composition as claimed in claim 1 or 2 in the drug of preparation treatment acne, which is characterized in that institute
State the drug and fragrant sand stomach Siberian cocklebur ball, nine rhubarb ball drug combinations for the treatment of acne.
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