CN109568252B - Preparation method of biochanin A solution, atomized liquid and taking method - Google Patents

Preparation method of biochanin A solution, atomized liquid and taking method Download PDF

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CN109568252B
CN109568252B CN201811386115.3A CN201811386115A CN109568252B CN 109568252 B CN109568252 B CN 109568252B CN 201811386115 A CN201811386115 A CN 201811386115A CN 109568252 B CN109568252 B CN 109568252B
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biochanin
butanediol
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张明
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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Abstract

The invention discloses a preparation method of a chickpea sprout essence A solution, an atomized liquid and an administration method. A preparation method of a chickpea sprout essence A solution comprises the steps of dissolving chickpea essence A in a mixed liquid of lecithin and moisturizing alcohol, and then adding water to dissolve the mixture to obtain the chickpea sprout essence A solution, wherein the moisturizing alcohol is 1, 3-butanediol and/or isoprene glycol. An administration method of atomized liquid comprises inhaling the water solution of biochanin A by atomization. The invention can improve the solubility and stability of the biochanin A, and can improve the comfort and effectiveness of taking by atomization.

Description

Preparation method of biochanin A solution, atomized liquid and taking method
Technical Field
The invention relates to the technical field of skin care, health care and medical treatment, in particular to a method for taking biochanin A.
Background
The biochanin A is a common health plant extract component, and various researches show that the biochanin A has rich effects, including hormone balance regulation, sleep improvement, alopecia reduction, blood vessel softening, depression improvement, Parkinson disease resistance and the like. The current main application is oral or smearing. The administration method can produce certain effect, but is not strong, mainly because the component is hardly dissolved in various common safe solvents, is basically insoluble in water, is slightly soluble in oil, and has weak absorption effect in oral administration. The solvent used in the previous dissolving of biochanin A is usually dimethyl sulfoxide, methanol and the like, has toxicity and cannot be directly used as medicines or eaten.
Disclosure of Invention
In order to overcome the problems in the prior art, the invention provides a preparation method of a chickpea sprout essence A solution, an atomized liquid and an administration method.
A preparation method of a chickpea sprout essence A solution comprises the steps of dissolving chickpea essence A in a mixed liquid of lecithin and moisturizing alcohol, and then adding water to dissolve the mixture to obtain the chickpea sprout essence A solution, wherein the moisturizing alcohol is 1, 3-butanediol and/or isoprene glycol.
Preferably, the biochanin is stirred and dissolved with 1, 3-butanediol or isoprene glycol, lecithin is added, the mixture is pressurized and stirred and dissolved, then the 1, 3-butanediol and isoprene glycol are added, the mixture is stirred and dissolved, and finally water is added, and the mixture is stirred and dissolved.
Preferably, 2g of the chickpea sprout essence and 2g of the butanediol solution are fully stirred and dissolved, then 0.5g of lecithin is added, the mixture is fully stirred and dissolved under pressure, then 4g of butanediol and 2g of isoprene glycol are added, the mixture is fully stirred, and finally water is added, and the mixture is stirred and dissolved.
Preferably, sodium ascorbyl phosphate is added into the chickpetin A solution.
Preferably, the purslane extract is added into the biochanin A solution.
Preferably, hydrolat or essential oil is added into the chickpea sprout essence A solution.
An atomized liquid easy to be absorbed by human body is prepared by the preparation method.
An application method of the atomized liquid is characterized in that the aqueous solution of the biochanin A is inhaled in an atomizing mode for use.
The invention has the beneficial effects that: by adopting the atomization mode, the biochanin A can enter arterial blood through the atomizer in the form of fine solution particles through a respiratory tract, and can be more efficiently conveyed to all parts of the whole body of a human body. The safe injection alcohols such as butanediol and isoprene glycol are used to dissolve the biochanin A in water and still be safe, and meanwhile, the moisturizing effect of the compound can reduce the stimulation of respiratory tract without adding normal saline in the aerosol inhalation process of a user, improve the comfort, and avoid the problem that the biochanin A is separated out and precipitated due to adding the normal saline, so that the biochanin A cannot be used; because the viscosity of the solution is increased due to the high content of butanediol and the atomization is not smooth, a certain proportion of low-viscosity isoprene glycol is added to reduce the viscosity, and the lecithin is added to be used as a solvent, so that the solution of the biochanin A is more stable and is not easy to precipitate, the long-term storage stability of the solution at a higher temperature such as 45 ℃ can be improved, and the lecithin is a nutrient substance beneficial to a human body.
Detailed Description
The invention is further illustrated by the following examples.
Firstly, dissolving the chickpoisol A solid powder in a mixed solution of moisturizing alcohol and lecithin by using a pressurized dissolver, then taking out the mixed solution, adding a proper amount of water to dissolve the mixed solution until the use concentration is reached, and obtaining the stable water solution of the chickpoisol A. The moisturizing alcohol is butanediol and isoprene glycol which are safe to inject.
And then putting the water solution of the biochanin A into an atomizer, starting atomization, and inhaling with breath. Generally, a more pronounced effect is produced than with a larger dose administered orally.
Examples and comparative examples
Take the subject with difficulty in sleeping in middle-aged people and frequent and urgent urination as an example.
1g of the dry powder of the biochanin A is orally taken every day, 7g of the dry powder is continuously taken for one week according to the traditional use method, and the sleeping is improved to a certain extent without other clear changes.
2g of the fine powder of the biochanin A is stirred in 100ml of water to form turbid liquid, 5ml of the fine powder is atomized and sucked every day for one week, the turbid liquid can be continuously used for one week, only a heavy and noisy compression type atomizer can be used after shaking up, and a portable mute type atomizer such as a micro-mesh type atomizer is easy to block. The subject has definite improvement effect in sleep 2 days later, and has the phenomenon of improving frequent micturition and urgent micturition. The feeling of atomization is very uncomfortable and severe stimulation is caused. The test subject is stopped for about one week, and the state of the test subject is recovered to the original state.
Fully stirring and dissolving 2g of biochanin A and 2g of butanediol, and stirring in 100ml of water to show that the biochanin A is slightly flocculent and condensed only after standing for a long time, and can be fully dispersed by shaking. At the moment, the micro-mesh atomizer or the compression atomizer can be used smoothly, the use stimulation is reduced a little, but the micro-mesh atomizer or the compression atomizer is still very uncomfortable. When the user uses the traditional Chinese medicine composition for one week, the sleep condition is remarkably and greatly improved, and the symptoms of frequent micturition and urgent micturition nearly disappear after the user uses the traditional Chinese medicine composition for one week.
Therefore, the chickpea sprout essence A with better atomization, inhalation and dissolution can greatly improve the using effect compared with the traditional oral administration mode. But further increases in comfort in use are desired.
Firstly, a normal saline solution is prepared, but a small amount of salt can cause the precipitation of the biochanin A. Then an attempt was made to increase the concentration of butylene glycol having a moisturizing effect. 2g of biochanin A and 8g of butanediol are fully stirred and dissolved, and then stirred in 100ml of water, so that the use feeling is comfortable and the irritation degree is basically negligible when the garbanzo is atomized and inhaled. But solution is too sticky, and the normal atomizing often can't be realized to the microgrid atomizer, and compression atomizer atomization effect also receives the influence. In addition, the precipitate still remains after long-term storage.
2g of biochanin A, 6g of butanediol and 2g of isoprene glycol are fully stirred and dissolved, then stirred in 100ml of water, when the mixture is atomized and inhaled, the use feeling is comfortable, and the micro-grid atomizer can realize normal atomization. The sediment still remains after long-term storage, but the use after shaking up is not influenced. Subsequently, it is found that the solution prepared according to the above has changed odor and state and becomes unstable in efficacy in a sterile high-temperature environment of 45 ℃ or higher for more than ten hours under the condition of antiseptic measures.
Through various attempts such as nano-wrapping and the like, the effect is poor, and finally the following process can realize stable and comfortable effect: firstly, 2g of biochanin and 2g of butanediol solution are fully stirred and dissolved, then 0.5g of lecithin is added, the mixture is fully stirred and dissolved under pressure, then 4g of butanediol and 2g of isoprene glycol are added, the mixture is fully stirred and dissolved in 100ml of water, the precipitation phenomenon of the solution is obviously further reduced, the stability is good, the atomization is easy, the solution has no change after 72 hours and 45 ℃ high temperature test, and the use feeling is comfortable. The use effect of the user is good. The final concentration of biochanin can be adjusted by adjusting the amount of water added last.
The specific ratio in this embodiment is an example, in which the sensory experience and the atomization viscosity of the solution can be adjusted by adjusting the ratio of butanediol to isoprene glycol, and generally, butanediol is used better but the viscosity is easy to increase to affect the atomization effect, and isoprene glycol is used less viscous but not as good as butanediol. And the addition of lecithin can make the solution more stable and obviously enhance the high-temperature-resistant storage stability. The required solution can be obtained only by dissolving in a small amount of moisturizing alcohol, adding a proper amount of lecithin for pressurized dissolution, and finally adding the moisturizing alcohol according to the use and experience requirements and dissolving in water.
The solution can be atomized for use, and has effects of reducing skin oil and reducing pores. Other functional components are added into the solution, so that the functions of the product can be further improved, for example, the highly stable water-soluble VC derivative, namely sodium ascorbyl phosphate, is added, and the functions of whitening, brightening and resisting oxidation can be achieved; the purslane extract is added, so that the allergy can be relieved; adding hydrolat or essential oil to adjust fragrance. And thus can be configured into a variety of different use experience products.
In addition, those skilled in the art will recognize that the moisturizing alcohols in the examples are butanediol and isoprene glycol, and that such injectable safe alcohol equivalents are within the scope of the present invention. Equivalent substitutions or modifications of other technical features are also within the scope of the present invention.

Claims (5)

1. A preparation method of a chickpea sprout essence A solution is characterized by comprising the following steps:
fully stirring and dissolving 2g of biochanin and 2g of 1, 3-butanediol solution, adding 0.5g of lecithin, pressurizing, fully stirring and dissolving, then adding 4g of 1, 3-butanediol and 2g of isoprene glycol, fully stirring, and finally adding water, and stirring and dissolving.
2. The formulation method of claim 1, wherein: adding sodium ascorbyl phosphate into the biochanin A solution.
3. The formulation method of claim 1, wherein: the purslane extract is added into the biochanin A solution.
4. The formulation method of claim 1, wherein: hydrolat or essential oil is added into the chickpea sprout essence A solution.
5. An atomized liquid easy to be absorbed by human body, which is characterized in that: obtained by the formulation process according to any one of claims 1 to 4.
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Publication number Priority date Publication date Assignee Title
CN110140964A (en) * 2019-05-23 2019-08-20 张明 Biochanin A is preparing purposes and oral liquor for sobering from wine in the product that relieves the effect of alcohol
CN110404049A (en) * 2019-07-23 2019-11-05 张明 Composition and the application of cardiovascular and cerebrovascular diseases and senile dementia are prevented and treated by Neulized inhalation
CN114377011A (en) * 2021-12-21 2022-04-22 素密肽(北京)科技有限公司 A preparation for supplementing neurotransmitter required by human body by aerosol inhalation

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CN1335133A (en) * 2000-07-28 2002-02-13 蛋白质技术国际公司 Composition and method for preventing and curing breast cancer
CN1965885A (en) * 2006-11-06 2007-05-23 中国人民解放军第四军医大学 Application of total flavones of chickpea in preparation of medicament for treating diabetes
CN103285070A (en) * 2013-06-03 2013-09-11 中国科学院新疆理化技术研究所 Preparation method and application of chickpea sprout extract dispersible tablet
CN110140964A (en) * 2019-05-23 2019-08-20 张明 Biochanin A is preparing purposes and oral liquor for sobering from wine in the product that relieves the effect of alcohol

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Publication number Priority date Publication date Assignee Title
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