CN109562135A - 基于Sedum telephium植物的叶子制备用于治疗感染的甲癣指甲的产品的方法 - Google Patents
基于Sedum telephium植物的叶子制备用于治疗感染的甲癣指甲的产品的方法 Download PDFInfo
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Abstract
基于Sedum telephium植物的叶子制备用于治疗感染的甲癣指甲的产品的方法。该过程涉及汽提离开的一侧接地，则剥离面浸有磺胺粉末，然后作为对受感染的指甲甲癣的敷料施加景天telephium皮肤。它还用于以甲癣感染的指甲上的乳膏或软膏形式局部施用。
Description
技术领域
本发明涉及一种产品的制备，通过该产品可以治愈被称为甲癣的人类指甲的感染。本发明的主要目的是与磺胺的浸渍比充分得到甲癣的愈合使用叶telephium景天植物。
背景技术
用于治疗甲癣的膏药是已知的。例如，WO99/40955A描述了一种具有压敏钢基质的贴剂，用于治疗甲癣。这种用于治疗脚趾和指甲的指甲真菌感染的装置由闭塞背衬层和压敏粘合剂基质层构成，其中有效量的抗真菌剂均匀分散，任选地与化学改进剂一起分散。
用于治疗甲癣的另一个处理是在US5464610A.利用这种处理，膏药制剂，其包含水杨酸或它的盐，酯或它们的混合物被用于说明。膏药制剂连接并输送存在于膏药制剂中的水杨酸，其量为制剂重量的10-80％。
组合物和拔出指甲护理和指甲和指甲床治疗感染在US5993790甲描述，其中包含喷雾水基钉，防腐剂指甲局部钉的组合物，尿素和要求保护天然添加剂该指甲油组合物适用于治疗指甲的真菌，酵母和细菌感染以及指甲的指甲。
US 5753256公开了一种用于治疗指甲真菌病的方法，包括柔性覆盖膜，聚合物基质丙烯酸酯覆盖膜密不可分的层和包含活性化合物从咪康唑中选择的石膏，益康唑，异康唑，噻康唑，特康唑，奥昔康唑，酮康唑，伊曲康唑，tolciclate，sulbentine，卤普罗近，灰黄霉素，环吡酮，特比萘芬，和这些化合物的盐。
US5181914A公开了一种用于治疗甲癣的粘性凝胶垫，其包括闭塞层，用于渗透的增强剂和抗真菌剂。US6303140A公开了一种用于治疗含有水杨酸作为活性成分的疣，鸡眼和老茧眼的膏药。US6303140还示出的是，当石膏被用于治疗甲癣的抗真菌剂可以作为克霉唑，布替萘芬，特比萘芬或咪康唑。
此外，在其中使用的植物作为固化剂的介绍专利是众所周知的，包括可引西班牙专利ES2104516Emeterio佩雷斯Ruiz的，其中的专利中使用相同科属的植物的(Crasulácea，Sedum)是该专利要求的人。它指的是使用植物Sedum album L的叶子与其他成分混合并声称它作为抗炎洗剂。
目前对单核细胞瘤的治疗
在国家卫生系统的出版物中。体积32，3/2008号，其Larruskain，Idígoras和其他医生说以下有关甲癣：指甲感染真菌引起的甲癣或(OM)是一种常见的方法。来自发达国家的大量研究给出了2-18％的人口流行率。癣菌，酵母菌和霉菌不癣菌：甲癣指甲感染是由三种类型的真菌产生。微生物诊断对于其治疗是必不可少的，因为它根据病原体和指甲病变的类型而变化。在灰指甲引起皮肤癣菌，最常见的，通常会影响脚趾甲，通常没有足够的局部治疗，需要长期大多数口服治疗的场合。口服特比萘芬和阿莫罗芬在漆中的组合是选择的治疗方案。在大多数酵母灰指甲，尤其影响指甲，漆阿莫罗芬或环吡酮是足够的愈合。引起皮肤癣菌模具并不少见，以避免偶尔的污染物混乱灰指甲，诊断应始终由两个或两个以上阳性培养证实。临床治愈更有可能结合口服和局部治疗。当不可能进行治疗期间以及在一些机会性真菌的真菌病可以使出姑息程序如通过由受影响的指甲的部分或全部切除寄生真菌去除部分的出现全身治疗或健康问题。首先应考虑局部治疗，因为其副作用有限。有几种基于咪唑，烯丙胺或多烯的抗真菌制剂。他们还使用具有抗真菌，防腐剂和角质往往如苯甲酸，过氧化苯甲酰或水杨酸性质，化学药制剂在没有其无效的证据。乳膏，软膏或溶液不能通过指甲板很好地扩散。
专门为指甲指示的产品以漆的形式呈现，抗真菌剂与指甲接触较长时间。这些医生继续说：·治“自然”的存在已经证明能有效地治疗灰指甲没有“自然”的方法。在部分支付在这些处理过程(卫生，去除过度角化的地区，切指甲护理更加重视一些家庭的方法(用醋清洗，化妆水植物等)被指控的治疗效果是由于经常等)。阿交烯，有机硫从大蒜的醇提取物获得的化合物，具有抗真菌作用，但没有足够的研究，以支持它的效用在出版商爱思唯尔期刊制药专业-3-PDF-13095632-S300的出版物2006年11月，医生琼达尔莫，以斯帖净资产收益率和其他人说的结论是：“在大的指甲角化许多作者建议，除了全身治疗，使用相结合的抗真菌剂(例如，联苯苄唑)的尿素漆指甲，以改善药物的渗透和减少指甲质量。一个有争议的问题是在开始治疗前去除指甲。这是一个痛苦的讨论并没有提供更有效的治疗各种研究，并在谁出于某种原因不能接受全身治疗的患者有40％的尿素，随后局部治疗因此只推荐化学萃取。迄今为止，没有治疗剂单独取得100％的成功。因此，与另一指甲油全身抗真菌剂3和6个月的关联是最有效的治疗甲癣，双脚和手。
发明内容
已经意外地发现，与磺胺粉的溶液中使用充实叶景天telephium厂已经愈合性能针对由真菌和酵母菌的指甲灰指甲非常快的效果。
通过所述方法获得的产品用于直接局部施用叶子或以乳膏或软膏的形式用于甲癣感染的指甲。
在一个实施方案中，本发明如下所述：
将叶子与Sedum telephium植物分开，仅从其一个面上移除皮肤-优选地是横梁。丢弃叶子后，在该表面上施加磺胺粉末的精细溶液，然后施加到感染的指甲上，完全覆盖它，包括围绕它的几毫米。在片材上，纱布完全叠加，并且在纱布上的粘合带或胶带将其牢固地保持在手指周围，应该连续保持至少12小时。
如果使用夜晚，则治疗更有效，因为不动会方便避免灰泥脱落。一旦该时间过去，必要时可以更换纸张。根据感染的进展，可能需要几天，尽管经验表明没有必要在超过一周的时间内应用治疗，在此期间感染完全消失。如果患者需要移动，他可以这样做，但由于石膏可能会移位，可能会延迟愈合。如果这种治疗方法的有效性与目前的结果相比是惊人的，因为所有的研究表明，灰指甲是一种感染是平时很叛逆，以目前的治疗，特别是中老年人或患有糖尿病。
Claims (3)
1.基于Sedum telephium植物叶子制备产品的程序，包括以下阶段：
a)在一侧剥去保护Sedum telephium植物叶子的皮肤。
b)一旦废弃叶片，应在表面浸渍磺胺粉末。
2.基于根据权利要求1的方法的步骤获得的Sedum telephium植物的叶子的产品。
3.根据权利要求2的产品的用途，用于制备用于治疗感染的甲癣指甲的局部药物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ESP201600663 | 2016-08-01 | ||
| ES201600663A ES2652313B1 (es) | 2016-08-01 | 2016-08-01 | Procedimiento de preparación de un producto a base de las hojas de la planta Sedum telephium para el tratamiento de las uñas infectadas de onicomicosis |
| PCT/ES2017/000095 WO2018024923A1 (es) | 2016-08-01 | 2017-07-26 | Procedimiento de preparación de un producto a base de las hojas de la planta sedum telephium para el tratamiento de las uñas infectadas de onicomicosis |
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| CN109562135A true CN109562135A (zh) | 2019-04-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201780047976.6A Pending CN109562135A (zh) | 2016-08-01 | 2017-07-26 | 基于Sedum telephium植物的叶子制备用于治疗感染的甲癣指甲的产品的方法 |
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| US (1) | US20190167744A1 (zh) |
| EP (1) | EP3492092A4 (zh) |
| CN (1) | CN109562135A (zh) |
| BR (1) | BR112019001952A2 (zh) |
| ES (1) | ES2652313B1 (zh) |
| WO (1) | WO2018024923A1 (zh) |
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| WO2012012390A1 (en) * | 2010-07-19 | 2012-01-26 | Marvphyt Development Llc | Botanical composition and methods of manufacture and use |
| US9364510B2 (en) * | 2011-07-19 | 2016-06-14 | Marvphyt Development Llc | Botanical composition and methods of manufacture and use |
| CN102743614B (zh) * | 2012-06-17 | 2014-01-01 | 胡桂荣 | 一种治疗阴部奇痒型霉菌性阴道炎的中药洗剂制备方法 |
| CN105194121A (zh) * | 2015-10-22 | 2015-12-30 | 黄鸿新 | 一种治疗灰指甲的外用液 |
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2016
- 2016-08-01 ES ES201600663A patent/ES2652313B1/es not_active Expired - Fee Related
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- 2017-07-26 BR BR112019001952-9A patent/BR112019001952A2/pt not_active IP Right Cessation
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- 2017-07-26 EP EP17836448.5A patent/EP3492092A4/en not_active Withdrawn
- 2017-07-26 CN CN201780047976.6A patent/CN109562135A/zh active Pending
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| Publication number | Publication date |
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| ES2652313B1 (es) | 2018-09-24 |
| WO2018024923A1 (es) | 2018-02-08 |
| US20190167744A1 (en) | 2019-06-06 |
| BR112019001952A2 (pt) | 2019-05-07 |
| EP3492092A1 (en) | 2019-06-05 |
| ES2652313A1 (es) | 2018-02-01 |
| EP3492092A4 (en) | 2020-05-20 |
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