CN109562077A - 组合物和治疗方法 - Google Patents

组合物和治疗方法 Download PDF

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Publication number
CN109562077A
CN109562077A CN201780019759.6A CN201780019759A CN109562077A CN 109562077 A CN109562077 A CN 109562077A CN 201780019759 A CN201780019759 A CN 201780019759A CN 109562077 A CN109562077 A CN 109562077A
Authority
CN
China
Prior art keywords
composition
terbinafine
nail
salt
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780019759.6A
Other languages
English (en)
Chinese (zh)
Inventor
约翰·瑞登
克里斯廷·卡罗琳·瑞登
大卫·库克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Blueberry Therapeutics Ltd
Original Assignee
Blueberry Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blueberry Therapeutics Ltd filed Critical Blueberry Therapeutics Ltd
Priority to CN202311073155.3A priority Critical patent/CN117379391A/zh
Publication of CN109562077A publication Critical patent/CN109562077A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Optics & Photonics (AREA)
  • Emergency Medicine (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CN201780019759.6A 2016-03-25 2017-03-24 组合物和治疗方法 Pending CN109562077A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202311073155.3A CN117379391A (zh) 2016-03-25 2017-03-24 组合物和治疗方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1605127.8 2016-03-25
GBGB1605127.8A GB201605127D0 (en) 2016-03-25 2016-03-25 Composition and methods of treatment
PCT/GB2017/050852 WO2017163091A1 (en) 2016-03-25 2017-03-24 Composition and methods of treatment

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202311073155.3A Division CN117379391A (zh) 2016-03-25 2017-03-24 组合物和治疗方法

Publications (1)

Publication Number Publication Date
CN109562077A true CN109562077A (zh) 2019-04-02

Family

ID=56027421

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201780019759.6A Pending CN109562077A (zh) 2016-03-25 2017-03-24 组合物和治疗方法
CN202311073155.3A Pending CN117379391A (zh) 2016-03-25 2017-03-24 组合物和治疗方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202311073155.3A Pending CN117379391A (zh) 2016-03-25 2017-03-24 组合物和治疗方法

Country Status (6)

Country Link
US (1) US12678414B2 (enExample)
EP (1) EP3432867A1 (enExample)
JP (2) JP7796465B2 (enExample)
CN (2) CN109562077A (enExample)
GB (1) GB201605127D0 (enExample)
WO (1) WO2017163091A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111629717A (zh) * 2017-06-30 2020-09-04 蓝莓疗法有限公司 由聚合物和特比萘芬形成的纳米颗粒

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12576049B1 (en) 2019-10-08 2026-03-17 Hallux Inc. Onychomycosis treatment methods
JP2022552252A (ja) 2019-10-08 2022-12-15 ハルクス，インコーポレイテッド 爪真菌症治療用組成物及び方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103429246A (zh) * 2010-12-29 2013-12-04 战略科学与技术有限责任公司 真菌感染和其它适应症的治疗的透皮递送
WO2015044669A1 (en) * 2013-09-25 2015-04-02 Blueberry Therapeutics Limited Antifungal topical composition and methods of treatment

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU223343B1 (hu) 1991-05-20 2004-06-28 Novartis Ag. Allil-amin-származékot tartalmazó gyógyászati készítmények és eljárás azok előállítására
US20030147925A1 (en) * 1998-09-11 2003-08-07 Samuel P. Sawan Topical dermal antimicrobial compositions, methods for generating same, and monitoring methods utilizing same
US20020009491A1 (en) 2000-02-14 2002-01-24 Rothbard Jonathan B. Compositions and methods for enhancing drug delivery across biological membranes and tissues
US9149440B2 (en) * 2003-09-02 2015-10-06 University Of South Florida Nanoparticles for drug-delivery
CA2565556A1 (en) * 2004-05-03 2005-12-08 Neosil, Inc. Polycationic antimicrobial therapeutic
WO2007012114A1 (en) 2005-07-25 2007-02-01 Nanotechnology Victoria Pty Ltd Microarray device
US20070249546A1 (en) 2006-04-22 2007-10-25 Sawaya Assad S Ophthalmic and related aqueous solutions containing antifungal agents, uses therefor and methods for preparing them
WO2010011354A2 (en) 2008-07-25 2010-01-28 Innovation Biomedical Devices, Inc. Enchanced trans-keratin drug delivery
AU2010336441B2 (en) 2009-12-23 2015-02-05 Nuvo Research Inc. Highly permeating terbinafine formulation for treating onychomycosis
GB201117538D0 (en) 2011-10-11 2011-11-23 Royal Veterinary College The Methods
EP2664327A1 (en) * 2012-05-14 2013-11-20 Almirall S.A. Topical pharmaceutical compositions comprising terbinafide and urea
US8697753B1 (en) * 2013-02-07 2014-04-15 Polichem Sa Method of treating onychomycosis
GB201511799D0 (en) 2015-07-06 2015-08-19 Blueberry Therapeutics Ltd Composition and methods of treatment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103429246A (zh) * 2010-12-29 2013-12-04 战略科学与技术有限责任公司 真菌感染和其它适应症的治疗的透皮递送
WO2015044669A1 (en) * 2013-09-25 2015-04-02 Blueberry Therapeutics Limited Antifungal topical composition and methods of treatment

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111629717A (zh) * 2017-06-30 2020-09-04 蓝莓疗法有限公司 由聚合物和特比萘芬形成的纳米颗粒

Also Published As

Publication number Publication date
GB201605127D0 (en) 2016-05-11
JP7796465B2 (ja) 2026-01-09
EP3432867A1 (en) 2019-01-30
CN117379391A (zh) 2024-01-12
JP2019509281A (ja) 2019-04-04
US20200206160A1 (en) 2020-07-02
WO2017163091A1 (en) 2017-09-28
US12678414B2 (en) 2026-07-14
JP2023182607A (ja) 2023-12-26

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SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
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RJ01 Rejection of invention patent application after publication

Application publication date: 20190402