CN109562067A - 制备脂质体的方法 - Google Patents

制备脂质体的方法 Download PDF

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Publication number
CN109562067A
CN109562067A CN201780047019.3A CN201780047019A CN109562067A CN 109562067 A CN109562067 A CN 109562067A CN 201780047019 A CN201780047019 A CN 201780047019A CN 109562067 A CN109562067 A CN 109562067A
Authority
CN
China
Prior art keywords
antibody
liposome
acid
liposomal encapsulated
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780047019.3A
Other languages
English (en)
Chinese (zh)
Inventor
I·雅韦里
K·内拉雅潘
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kurilkes Co Ltd
Original Assignee
Kurilkes Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/226,364 external-priority patent/US10143652B2/en
Application filed by Kurilkes Co Ltd filed Critical Kurilkes Co Ltd
Publication of CN109562067A publication Critical patent/CN109562067A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201780047019.3A 2016-08-02 2017-08-01 制备脂质体的方法 Pending CN109562067A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/226,364 US10143652B2 (en) 2009-09-23 2016-08-02 Methods for the preparation of liposomes
US15/226,364 2016-08-02
PCT/US2017/044865 WO2018026794A1 (en) 2016-08-02 2017-08-01 Methods for the preparation of liposomes

Publications (1)

Publication Number Publication Date
CN109562067A true CN109562067A (zh) 2019-04-02

Family

ID=61073551

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780047019.3A Pending CN109562067A (zh) 2016-08-02 2017-08-01 制备脂质体的方法

Country Status (5)

Country Link
EP (1) EP3493790A4 (ja)
JP (1) JP7019201B2 (ja)
CN (1) CN109562067A (ja)
CA (1) CA3032810A1 (ja)
WO (1) WO2018026794A1 (ja)

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US5641637A (en) * 1991-01-11 1997-06-24 Cobe Laboratories, Inc. Method of preparing lyophilized and frozen cell standards
US6156337A (en) * 1994-07-08 2000-12-05 Opperbas Holding B.V. Method for high loading of vesicles with biopolymeric substances
US20060110441A1 (en) * 2004-10-28 2006-05-25 Harry Wong Lyophilized liposome formulations and method
CN1798545A (zh) * 2003-06-04 2006-07-05 乔治敦大学 改良脂质体复合物的稳定性和保存期的方法
US20080279927A1 (en) * 2002-12-31 2008-11-13 Bharat Serums & Vaccines Ltd Non-Pegylated Long-Circulating Liposomes
US20080286350A1 (en) * 2004-10-06 2008-11-20 Bc Cancer Agency Formulation of Multivalent Antibody Constructs and Use of Same for Cancer Therapy
WO2009038779A2 (en) * 2007-09-19 2009-03-26 University Of Tennessee Research Foundation Methods and compositions for inhibiting undesirable cellular proliferation by targeted liposome delivery of active agents
WO2009064696A1 (en) * 2007-11-14 2009-05-22 The Regents Of The University Of California Sterol-modified amphiphilic lipids
US20090221953A1 (en) * 2008-02-26 2009-09-03 Kazuaki Kajimoto Composition comprising protein-liposome complex for iontophoresis
CN102100916A (zh) * 2009-12-22 2011-06-22 上海抗体药物国家工程研究中心有限公司 一种冻干脂质体、其制备方法和用途
US20120231066A1 (en) * 2011-01-24 2012-09-13 Henry John Smith Multi-drug liposomes to treat tumors
CN103619325A (zh) * 2011-07-04 2014-03-05 国立血清研究所 用于生产脂质体的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020197210A1 (en) * 2001-03-08 2002-12-26 Bednarski Mark David Stabilized therapeutic and imaging agents
DE602004019546D1 (de) * 2003-08-26 2009-04-02 Smithkline Beecham Corp Heterofunktionelle copolymere von glycerol und polyethylenglykol, ihre konjugate und zusammensetzungen
WO2005034979A2 (en) * 2003-10-11 2005-04-21 Inex Pharmaceuticals Corporation Methods and compositions for enhancing innate immunity and antibody dependent cellular cytotoxicity
JP2006248978A (ja) * 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
MX2007013200A (es) * 2005-04-22 2008-03-24 Johnson & Johnson Composicion de inmunoliposoma para el direccionamiento hacia un receptor de la celula her2.
JP2006316040A (ja) * 2005-05-13 2006-11-24 Genentech Inc Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法
WO2007127272A2 (en) * 2006-04-24 2007-11-08 The Cbr Institute For Biomedical Research Method of producing immunoliposomes and compositions thereof
EP2480209A1 (en) * 2009-09-23 2012-08-01 Indu Javeri Methods for the preparation of liposomes comprising docetaxel
CN104080480A (zh) * 2012-01-01 2014-10-01 奇比艾企业有限公司 用于选择性递送治疗剂和诊断剂的endo180靶向微粒
HUE048780T2 (hu) * 2012-08-16 2020-09-28 Ipierian Inc Tauopátia kezelésére szolgáló módszerek
EP2711000B1 (en) * 2012-09-19 2019-04-03 Georgetown University Targeted Liposomes

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US5641637A (en) * 1991-01-11 1997-06-24 Cobe Laboratories, Inc. Method of preparing lyophilized and frozen cell standards
US6156337A (en) * 1994-07-08 2000-12-05 Opperbas Holding B.V. Method for high loading of vesicles with biopolymeric substances
US20080279927A1 (en) * 2002-12-31 2008-11-13 Bharat Serums & Vaccines Ltd Non-Pegylated Long-Circulating Liposomes
CN1798545A (zh) * 2003-06-04 2006-07-05 乔治敦大学 改良脂质体复合物的稳定性和保存期的方法
US20080286350A1 (en) * 2004-10-06 2008-11-20 Bc Cancer Agency Formulation of Multivalent Antibody Constructs and Use of Same for Cancer Therapy
US20060110441A1 (en) * 2004-10-28 2006-05-25 Harry Wong Lyophilized liposome formulations and method
WO2009038779A2 (en) * 2007-09-19 2009-03-26 University Of Tennessee Research Foundation Methods and compositions for inhibiting undesirable cellular proliferation by targeted liposome delivery of active agents
WO2009064696A1 (en) * 2007-11-14 2009-05-22 The Regents Of The University Of California Sterol-modified amphiphilic lipids
CN101909581A (zh) * 2007-11-14 2010-12-08 加利福尼亚大学董事会 固醇修饰的两亲脂质
US20090221953A1 (en) * 2008-02-26 2009-09-03 Kazuaki Kajimoto Composition comprising protein-liposome complex for iontophoresis
CN102100916A (zh) * 2009-12-22 2011-06-22 上海抗体药物国家工程研究中心有限公司 一种冻干脂质体、其制备方法和用途
US20120231066A1 (en) * 2011-01-24 2012-09-13 Henry John Smith Multi-drug liposomes to treat tumors
CN103619325A (zh) * 2011-07-04 2014-03-05 国立血清研究所 用于生产脂质体的方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HELEN LOUGHREY ET AL.: ""A non-covalent method of attaching antibodies to liposomes"", 《BIOCHIMICA ET BIOPHYSICA ACTA》 *
IMRAN AHMAD ET AL.: ""Antibody-mediated Specific Binding and Cytotoxicity of Liposome-entrapped Doxorubicin to Lung Cancer Cells in Vitro"", 《CANCER RESEARCH》 *

Also Published As

Publication number Publication date
WO2018026794A1 (en) 2018-02-08
EP3493790A1 (en) 2019-06-12
CA3032810A1 (en) 2018-02-08
EP3493790A4 (en) 2020-03-25
JP2019526619A (ja) 2019-09-19
JP7019201B2 (ja) 2022-02-15

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