CN109549881A - 一种复合植物防脱生发液的制备方法 - Google Patents
一种复合植物防脱生发液的制备方法 Download PDFInfo
- Publication number
- CN109549881A CN109549881A CN201710881669.XA CN201710881669A CN109549881A CN 109549881 A CN109549881 A CN 109549881A CN 201710881669 A CN201710881669 A CN 201710881669A CN 109549881 A CN109549881 A CN 109549881A
- Authority
- CN
- China
- Prior art keywords
- extract
- extraction
- preparation
- alcohol
- hair growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 230000003779 hair growth Effects 0.000 title claims abstract description 22
- 239000002131 composite material Substances 0.000 title claims abstract description 20
- 239000000284 extract Substances 0.000 claims abstract description 50
- 241000196324 Embryophyta Species 0.000 claims abstract description 25
- 241000218636 Thuja Species 0.000 claims abstract description 17
- 235000001287 Guettarda speciosa Nutrition 0.000 claims abstract description 9
- 238000001914 filtration Methods 0.000 claims abstract description 8
- 235000020710 ginseng extract Nutrition 0.000 claims abstract description 8
- 241000246044 Sophora flavescens Species 0.000 claims abstract description 7
- 239000000419 plant extract Substances 0.000 claims abstract description 5
- 244000061520 Angelica archangelica Species 0.000 claims abstract 4
- 230000001954 sterilising effect Effects 0.000 claims abstract 2
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 53
- 238000000605 extraction Methods 0.000 claims description 40
- 235000019441 ethanol Nutrition 0.000 claims description 28
- 239000000706 filtrate Substances 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 14
- 229960004756 ethanol Drugs 0.000 claims description 13
- 238000010298 pulverizing process Methods 0.000 claims description 12
- 241000208340 Araliaceae Species 0.000 claims description 10
- 241000180649 Panax notoginseng Species 0.000 claims description 10
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 10
- 235000008109 Thuja occidentalis Nutrition 0.000 claims description 10
- 239000011347 resin Substances 0.000 claims description 10
- 229920005989 resin Polymers 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 235000008434 ginseng Nutrition 0.000 claims description 9
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 8
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 8
- 230000002745 absorbent Effects 0.000 claims description 7
- 239000002250 absorbent Substances 0.000 claims description 7
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 7
- 229930003944 flavone Natural products 0.000 claims description 6
- 235000011949 flavones Nutrition 0.000 claims description 6
- 150000004676 glycans Chemical class 0.000 claims description 6
- 229920001282 polysaccharide Polymers 0.000 claims description 6
- 239000005017 polysaccharide Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 238000010828 elution Methods 0.000 claims description 5
- 150000002213 flavones Chemical class 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 4
- 238000004108 freeze drying Methods 0.000 claims description 4
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 4
- 229930182490 saponin Natural products 0.000 claims description 4
- 150000007949 saponins Chemical class 0.000 claims description 4
- MZNDIOURMFYZLE-UHFFFAOYSA-N butan-1-ol Chemical compound CCCCO.CCCCO MZNDIOURMFYZLE-UHFFFAOYSA-N 0.000 claims description 3
- 230000006837 decompression Effects 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 3
- 235000019640 taste Nutrition 0.000 claims description 3
- 241000218691 Cupressaceae Species 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- 238000011010 flushing procedure Methods 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims description 2
- 238000001179 sorption measurement Methods 0.000 claims description 2
- 230000003068 static effect Effects 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 210000004761 scalp Anatomy 0.000 abstract description 3
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 230000028327 secretion Effects 0.000 abstract description 2
- 230000001256 tonic effect Effects 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract 1
- 241000125175 Angelica Species 0.000 description 6
- 201000004384 Alopecia Diseases 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 230000003213 activating effect Effects 0.000 description 3
- 208000024963 hair loss Diseases 0.000 description 3
- 230000003676 hair loss Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 206010039897 Sedation Diseases 0.000 description 2
- 244000046101 Sophora japonica Species 0.000 description 2
- 235000010586 Sophora japonica Nutrition 0.000 description 2
- 231100000360 alopecia Toxicity 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000003778 catagen phase Effects 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- -1 flavone compound Chemical class 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000036280 sedation Effects 0.000 description 2
- AXPZIVKEZRHGAS-UHFFFAOYSA-N 3-benzyl-5-[(2-nitrophenoxy)methyl]oxolan-2-one Chemical compound [O-][N+](=O)C1=CC=CC=C1OCC1OC(=O)C(CC=2C=CC=CC=2)C1 AXPZIVKEZRHGAS-UHFFFAOYSA-N 0.000 description 1
- 241000382455 Angelica sinensis Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 244000037364 Cinnamomum aromaticum Species 0.000 description 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 description 1
- 241001478240 Coccus Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 244000007703 Mentha citrata Species 0.000 description 1
- 235000007421 Mentha citrata Nutrition 0.000 description 1
- 235000008660 Mentha x piperita subsp citrata Nutrition 0.000 description 1
- HDPISCIDKUMRDI-UHFFFAOYSA-M N(=O)[O-].[Na+].[N+](=O)([O-])[O-].[Al+3] Chemical compound N(=O)[O-].[Na+].[N+](=O)([O-])[O-].[Al+3] HDPISCIDKUMRDI-UHFFFAOYSA-M 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 240000002924 Platycladus orientalis Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 230000003471 anti-radiation Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229940107131 ginseng root Drugs 0.000 description 1
- 229930182494 ginsenoside Natural products 0.000 description 1
- 229940089161 ginsenoside Drugs 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000003660 hair regeneration Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 229940105902 mint extract Drugs 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/008—Preparations for oily hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明实施例提供一种复合植物防脱生发液的制备方法，涉及化妆品领域，复合植物防脱生发液采用纯天然植物成分，温和无刺激，具有调节头皮油脂分泌，激活毛母细胞，能有效起到防脱、生发的作用。该复合植物防脱生发液的制备方法包括：将五种植物提取物包括人参提取物、侧柏提取物、苦参提取物、三七提取物、当归提取物按照质量比3:3:2:1:1混合，于万级制备车间，0.22μm过滤除菌，得到复合植物防脱生发液。
Description
技术领域
本发明涉及化妆品制造领域，尤其涉及一种复合植物防脱生发液的制备方法。
背景技术
脱发是头发脱落的现象，正常脱落的头发都是处于退行期及休止期的毛发，由于进入退行期与新进入生长期的毛发不断处于动态平衡，故能维持正常数量的头发。但随着社会压力不断增大和生活节奏的加快，环境的不断恶化，以及不良饮食的饮食习惯，中国的脱发患者越来越多。
由于生发产品科技含量高，脱发是多种疾病的综合症被医学家称为“顽症”，而传统的治疗方法又很难奏效。而复合植物防脱生发液能有效改善头部毛细血管循环，补气养血，对头发脱落有明显治疗作用。
人参[Panax ginseng C. A. Mey.]为五加科植物人参的干燥根。性甘、微苦，平。主补五脏，具有补元气，补脾益肺，生津安神的作用。主要成分为人参皂苷，研究表明，人参提取物能够提高头发的强韧度，防止脱发，长期使用可使头发乌黑亮泽，使毛发粗壮，浓密。
侧柏叶为柏科植物侧柏[Platycladusorientalis( L.) Franco]的干燥枝梢及叶，其性味苦涩、性寒，具有凉血止血的功效。侧柏叶的主要成分为鞣质、黄酮及挥发油等。侧柏叶除具有止血、镇咳、平喘、祛痰、镇静作用外, 对金黄色葡萄球菌、卡地球菌、痢疾杆菌、伤寒杆菌等均有抑制作用。《本草衍义补遗》曾记载侧柏治疗脱发的作用:“黑润鬓发”。
三七为五加科植物[Panaxnotoginseng（Burk.）]的干燥根。味甘微苦，性平无毒。入肝、胃、大肠经。三七主要含皂苷、黄酮、氨基酸等，具有活血化瘀，消肿定痛、疏经通络、祛风除湿的功效。三七提取物对b-16黑色素细胞活性有促进作用，可增加黑色素的生成量，可用于黑发类制品。
苦参为豆科槐属植物苦参的干燥根，又名水槐、地槐、白茎，始载于《神农本草经》，列为中品，是我国常用传统中药。传统药理作用以抑菌、抗心律失常为主。其所含化学成分主要为生物碱和黄酮类化合物。苦参能够清除下焦湿热，并且杀虫止痒对皮肤瘙痒有很好的缓解作用。能够平衡油脂分泌，疏通并收敛毛孔，清除皮肤内毒素杂质。
当归为伞形科植物当归[Angelica sinensis(Oliv.)Diels]的干燥根，是一种常用的传统中药，有补血活血、调经止痛、润肠通便之功效。近年来对当归的药理研究表明，从其水溶性部分提取的当归多糖具有丰富的生物活性，具有明显的补血活血、免疫调节、抗肿瘤、抗辐射损伤等药理活性。除此之外，当归能扩张头皮及皮肤的毛细血管、促进血液循环，防止脱发，滋润皮肤毛发，并使头发乌黑发亮。
本发明旨在提供一种复合植物防脱生发液，主要包括五种植物提取物的复合，包括人参提取物、侧柏叶提取物、苦参提取物、三七提取物、当归提取物。并阐明一种复合植物防脱生发液的制备方法。
本发明的目的之一是，提供一种复合植物防脱生发液的制备方法。
本发明的目的之二是，提供一种纯天然安全无刺激的毛发再生原料添加剂。
发明内容
本发明实施例提供了一种复合植物防脱生发液的制备方法，采用纯天然植物成分，温和无刺激，具有调节头皮油脂分泌，激活毛母细胞，能有效起到防脱、生发的作用。
为达到上述目的，本发明实施例采用如下技术方案：
本发明的技术方案如下：
复合植物防脱生发液的制备，主要包括以下几个步骤：
（1）人参提取物的制备：包括药材粉碎，加入70%的乙醇提取，抽滤，合并滤液减压浓缩，冷冻干燥。
其中，药材粉碎力度若过大，会影响有效成分的提取率；粉碎力度过小，则需消耗更多的能量，因此选择80目过筛。所述的提取液为70%乙醇，能够高效提取人参中的皂苷成分。所述料液比为1:8~1:10，提取温度为80℃，提取时间为2h，提取次数3次，减压浓缩温度为70℃。
（2）苦参黄酮的制备：包括药材粉碎，加入75%酒精进行浸渍提取，抽滤，合并滤液减压浓缩，所得浓缩浸膏经过AB-8大孔吸附树脂分离，依次采用水、70%的乙醇洗脱，收集70%乙醇洗脱液，所得样品冷冻干燥，样品采用亚硝酸钠—硝酸铝法测定黄酮含量。
其中，浸提温度选择50-60℃；所述料液比为1：10~1:15；所述提取次数为3次，提取时间为5~10h每次。大孔吸附树脂上样量与树脂质量比为1:10~1:15，静态吸附6~10h，洗脱体积为柱体积的3~5倍，流速20-100ml/min。
（3）侧柏提取物的制备：包括干燥粉碎，加入75%的酒精进行浸渍提取，抽滤，合并滤液减压浓缩，所得侧柏浸膏静置两天，取下层进行冷冻干燥，备用。
其中，所述提取温度为常温，提取次数3~4次，提取时间每次3天；得到的侧柏浸膏，静置两天后，取下层进行冷冻干燥。
（4）三七提取物的制备：包括药材粉碎，加入75%的酒精进行浸渍提取，抽滤；合并滤液减压浓缩，所得浸膏进行正丁醇萃取，干燥备用。
其中，所述提取温度为50-60℃，提取次数3~4次，料液比1:10~1:15提取时间5~8h每次；所得到的浸膏于分液漏斗中，加入2倍体积的正丁醇(n-Butanol)，充分搅拌，放置于室温静置6 h以上，吸出上层液，得正丁醇萃取液，重复萃取四次。
（5）当归提取物制备：包括药材粉碎，水煎煮提取，过滤，合并滤液减压浓缩，加入无水乙醇，4℃冰箱静置过滤，即得当归多糖。
其中，所述提取温度为100℃，提取时间为2h，提取次数3次；所述减压浓缩温度为48~55℃；所述加入无水乙醇至溶液体系醇浓度80%，4℃冰箱静置过滤，并用无水乙醇反复冲洗，挥至无醇味，即得一定含量的当归多糖。
（6）一种复合植物防脱生发液主要包括上述人参提取物、侧柏提取物、三七提取物、苦参提取物、当归提取物五种植物提取物的复合物。各组分的质量百分比为人参：侧柏：三七：苦参：当归=3:3:2:1:1。
本发明使用的大孔吸附树脂的预处理：用95%乙醇浸泡24小时以上，用乙醇湿法装柱。继续用乙醇洗脱至洗脱液与水混合为澄清为止。接着用5%的稀盐酸洗脱柱子至7~8个柱体积，再用水洗脱至洗脱液的PH值为中性为止。并将液面放至与树脂齐平，以便上样。
本发明的有益效果：
（1）本发明的优点和效果在于采用科学先进的制备手段，包括中压、高压液相制备、凝胶分离、大孔吸附树脂分离、萃取技术等，分离高纯度高活性天然植物成分；
（2）本发明中涉及到天然植物提取原料，分别从不同的途径防脱生发，从而实现多层次多途径防脱。
附图说明
附图1为复合植物防脱生发液的提取制备工艺流程图。
具体实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行详细地描述。
复合植物防脱生发液的生产制备工艺如图1所示，具体过程如下：
1）取500g人参，药材粉碎，过80目筛，加入5L 70%的乙醇提取3次，提取温度为80℃，每次2h，合并所得滤液，抽滤，减压浓缩，冷冻干燥，得人参粉末共计50g，测定皂苷的含量为50%。
2）取侧柏500g，药材粉碎，加入6L 75%的乙醇常温浸渍提取3次，每次3天，合并所得滤液，抽滤，减压浓缩成浸膏，静置两天后，取下层进行冷冻干燥，得到侧柏粉末40g。
3）干燥三七（非炮制）3.5Kg，用75%的工业酒精50 L常温浸泡4次，每次3天，抽滤；将以上所得滤液全部合并，用旋转蒸发仪于60 ̊C浓缩；得三七总醇提浸膏，加入少量的水使其成为混悬液，置于分液漏斗中，加入2倍体积的正丁醇(n-Butanol)，充分搅拌，放置于室温静置6 h以上，吸出上层液，得正丁醇萃取液，重复萃取四次，得到萃取液浓缩，得三七正丁醇粉末293g。
4）干燥苦参（非炮制）2 Kg，用95%的工业酒精50 L常温浸泡3次，每次3天，抽滤；将以上所得滤液全部合并，用旋转蒸发仪于60 ̊C浓缩，得苦参总醇提浸膏。AB-8大孔吸附树脂分离，75%的乙醇洗脱，浓缩，得到苦参提取物60g。
5）取当归1 KG，用10倍量水浸泡1小时，水煎煮90min，重复提取2次，合并滤液，70℃旋蒸浓缩。取一定体积的浓缩液，加入无水乙醇，至溶液体系醇浓度80%，4℃冰箱静置过滤，并用无水乙醇反复冲洗，挥至无醇味。并按照硫酸-苯酚发测定当归多糖含量，多糖含量为40%，得到当归提取物300g。
6）上述所得提取物按照人参提取物3mg/ml，侧柏提取物3 mg/ml，三七提取物2mg/ml，苦参提取物1 mg/ml，当归提取物1 mg/ml，溶解于50%的1,3-丁二醇水中，即得复合植物防脱生发液。
以上所述，仅为本发明的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，可轻易想到变化或替换，都应涵盖在本发明的保护范围之内。因此，本发明的保护范围应以所述权利要求的保护范围为准。
Claims (8)
1.一种复合植物防脱生发液的制备方法，其特征在于，将五种植物提取物包括人参提取物、侧柏提取物、苦参提取物、三七提取物、当归提取物按照质量比3:3:2:1:1混合，于万级制备车间，0.22μm过滤除菌，得到复合植物防脱生发液。
2.根据权利要求1所述的方法，其特征在于，所述复合植物防脱生发液的制备方法，具体包括：
（1）人参提取物的制备：包括药材粉碎，加入70%的乙醇提取，抽滤，合并滤液减压浓缩，冷冻干燥；
（2）苦参黄酮的制备：包括药材粉碎，加入75%酒精进行浸渍提取，抽滤，合并滤液减压浓缩，所得浓缩浸膏经过AB-8大孔吸附树脂分离，收集70%乙醇洗脱液，所得样品冷冻干燥，备用；
（3）侧柏提取物的制备：包括干燥粉碎，加入75%的酒精进行浸渍提取，抽滤，合并滤液减压浓缩，所得侧柏浸膏静置两天，取下层进行冷冻干燥，备用；
（4）三七提取物的制备：包括药材粉碎，加入75%的酒精进行浸渍提取，抽滤；合并滤液减压浓缩，所得浸膏进行正丁醇萃取，干燥备用；
（5）当归提取物制备：包括药材粉碎，水煎煮提取，过滤，合并滤液减压浓缩，加入无水乙醇，4℃冰箱静置过滤，即得当归多糖；
（6）一种复合植物防脱生发液主要包括上述人参提取物、苦参提取物、当归提取物、三七提取物、侧柏提取物五种植物提取物的复合物；
各组分的质量百分比为人参：侧柏：三七：苦参：当归=3:3:2:1:1。
3.根据权利要求2所述的方法，其特征在于，所述步骤（1）中药材粉碎力度若过大，会影响有效成分的提取率；粉碎力度过小，则需消耗更多的能量，因此选择30目过筛；所述的提取溶剂为70%乙醇，能够高效的提取人参中的有效皂苷类成分；所述提取料液比为1:8~1:10，提取温度为80℃，提取时间为2h，提取次数3次，减压浓缩温度为70℃。
4.根据权利要求2所述的方法，其特征在于，所述步骤（2）药材粉碎选择30目过筛，温度过高会导致有效成分分解变质，温度过低则耗时费力，因此浸提温度选择50-60℃；所述料液比为1：10~1:15；所述提取次数为3~4次，提取时间为5~10h每次；大孔吸附树脂上样量与树脂质量比为1:10~1:15，静态吸附6~10h，洗脱体积为柱体积的3~5倍，流速20-100ml/min。
5.根据权利要求2所述的方法，其特征在于，步骤（3）所述提取温度为常温，提取次数3~4次，提取时间每次3天；得到的侧柏浸膏，静置两天后，取下层进行冷冻干燥。
6.根据权利要求2所述的方法，其特征在于，步骤（4）所述提取温度为50-60℃，提取次数3~4次，料液比1:10~1:15，提取时间5~8h，所得到的浸膏于分液漏斗中，加入2倍体积的正丁醇(n-Butanol)，充分搅拌，放置于室温静置6 h以上，吸出上层液，得正丁醇萃取液，重复萃取四次。
7.根据权利要求2所述的方法，其特征在于，步骤（5）所述提取温度为100℃，提取时间为2h，提取次数3次；所述减压浓缩温度为48~55℃；所述加入无水乙醇至溶液体系醇浓度80%，4℃冰箱静置过滤，并用无水乙醇反复冲洗，挥至无醇味，即得一定含量的当归多糖。
8.根据权利要求2所述的方法，其特征在于，所述步骤（5）组分的质量百分比为人参：侧柏：三七：苦参：当归=3:3:2:1:1。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710881669.XA CN109549881A (zh) | 2017-09-26 | 2017-09-26 | 一种复合植物防脱生发液的制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710881669.XA CN109549881A (zh) | 2017-09-26 | 2017-09-26 | 一种复合植物防脱生发液的制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109549881A true CN109549881A (zh) | 2019-04-02 |
Family
ID=65862542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710881669.XA Pending CN109549881A (zh) | 2017-09-26 | 2017-09-26 | 一种复合植物防脱生发液的制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109549881A (zh) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110478409A (zh) * | 2019-08-15 | 2019-11-22 | 谢伟星 | 基于草本营养生发和去屑的草本养发液及其使用方法 |
| CN111000778A (zh) * | 2019-11-23 | 2020-04-14 | 广东天仁科技有限公司 | 一种防脱育发液及其制备方法 |
| CN111991413A (zh) * | 2020-09-18 | 2020-11-27 | 中国人民解放军陆军特色医学中心 | 一种预防脱发或促进毛发生长的多糖组合物及其制剂和应用 |
| CN112120990A (zh) * | 2020-07-22 | 2020-12-25 | 广州市圣莎拉化妆品有限公司 | 一种基于侧柏叶植物型防脱生发产品及加工提取工艺 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102228420A (zh) * | 2011-07-06 | 2011-11-02 | 孙代龙 | 毛发保健用品及其制备方法 |
| CN104473805A (zh) * | 2014-11-24 | 2015-04-01 | 福建春辉生物工程有限公司 | 一种茶油护发素 |
| CN104739704A (zh) * | 2013-12-28 | 2015-07-01 | 大连美乐生物技术开发有限公司 | 一种中药液及其制备方法 |
| CN105125609A (zh) * | 2015-09-30 | 2015-12-09 | 桂林三宝药业有限公司 | 一种从三七中提取三七总皂甙的方法 |
| CN105963426A (zh) * | 2015-03-11 | 2016-09-28 | 人参科学有限公司 | 含有混合草药的提取物或其加工提取物的用于预防和治疗脱发的组合物及其用途 |
| CN106491438A (zh) * | 2016-11-28 | 2017-03-15 | 广西慧投互联网金融服务有限公司 | 一种乌发生发的中药洗发液 |
| CN107019789A (zh) * | 2017-05-27 | 2017-08-08 | 云南白药集团股份有限公司 | 防脱育发中药组合物、其制备方法及应用 |
-
2017
- 2017-09-26 CN CN201710881669.XA patent/CN109549881A/zh active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102228420A (zh) * | 2011-07-06 | 2011-11-02 | 孙代龙 | 毛发保健用品及其制备方法 |
| CN104739704A (zh) * | 2013-12-28 | 2015-07-01 | 大连美乐生物技术开发有限公司 | 一种中药液及其制备方法 |
| CN104473805A (zh) * | 2014-11-24 | 2015-04-01 | 福建春辉生物工程有限公司 | 一种茶油护发素 |
| CN105963426A (zh) * | 2015-03-11 | 2016-09-28 | 人参科学有限公司 | 含有混合草药的提取物或其加工提取物的用于预防和治疗脱发的组合物及其用途 |
| CN105125609A (zh) * | 2015-09-30 | 2015-12-09 | 桂林三宝药业有限公司 | 一种从三七中提取三七总皂甙的方法 |
| CN106491438A (zh) * | 2016-11-28 | 2017-03-15 | 广西慧投互联网金融服务有限公司 | 一种乌发生发的中药洗发液 |
| CN107019789A (zh) * | 2017-05-27 | 2017-08-08 | 云南白药集团股份有限公司 | 防脱育发中药组合物、其制备方法及应用 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110478409A (zh) * | 2019-08-15 | 2019-11-22 | 谢伟星 | 基于草本营养生发和去屑的草本养发液及其使用方法 |
| CN111000778A (zh) * | 2019-11-23 | 2020-04-14 | 广东天仁科技有限公司 | 一种防脱育发液及其制备方法 |
| CN112120990A (zh) * | 2020-07-22 | 2020-12-25 | 广州市圣莎拉化妆品有限公司 | 一种基于侧柏叶植物型防脱生发产品及加工提取工艺 |
| CN111991413A (zh) * | 2020-09-18 | 2020-11-27 | 中国人民解放军陆军特色医学中心 | 一种预防脱发或促进毛发生长的多糖组合物及其制剂和应用 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109549881A (zh) | 一种复合植物防脱生发液的制备方法 | |
| CN101973853B (zh) | 羟基酪醇的提取方法 | |
| CN104784507A (zh) | 一种具有多重美容功效的中药组合物及其制备方法和应用 | |
| CN107300600A (zh) | 一种中药制剂生发丸的鉴定方法 | |
| CN101085802B (zh) | 一种三七总皂苷的制备方法 | |
| CN106581108B (zh) | 一种脱除人参提取物中残留农药霜霉威的方法 | |
| CN100400064C (zh) | 一种甙类化合物制剂及制备方法 | |
| KR101281059B1 (ko) | 삼푸조성물 및 그 제조 방법 | |
| CN103536687B (zh) | 一种改善睡眠的保健品 | |
| CN103126970A (zh) | 用于防脱发或促进毛发生长的组合物 | |
| KR101390108B1 (ko) | 구증구포 인삼 추출물과 천연 한방 추출물을 함유하는 탈모방지용 화장료 조성물 | |
| CN103735973A (zh) | 一种改善记忆力的中药组合物及其制备方法 | |
| CN101084954B (zh) | 一种西洋参总皂苷的制备方法 | |
| CN1288168C (zh) | 一种多糖类化合物制剂及制备方法 | |
| CN109453234A (zh) | 桑白皮制品及其制备方法 | |
| CN103251659B (zh) | 一种银杏叶精的制备方法 | |
| AU2012247916A1 (en) | Chinese herbal extract, preparing method and application thereof | |
| CN104383191B (zh) | 一种清肝降压的中药组合物及制备方法 | |
| KR101281060B1 (ko) | 모발생장촉진 조성물 및 그 제조 방법 | |
| CN103520397B (zh) | 一种治疗毛发红糠疹的中药 | |
| KR102533237B1 (ko) | 한방복합추출물을 유효성분으로 함유하는 탈모방지 또는 두피개선용 화장료 조성물 | |
| CN116889269B (zh) | 一种提高人体免疫力的中药材固体饮料 | |
| CN106977465A (zh) | 一种从川芎的茎叶中提取川芎嗪的方法 | |
| CN100579558C (zh) | 一种治疗心脑血管疾病的颗粒剂的质量控制方法 | |
| CN101259179A (zh) | 中药脑得生软胶囊及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 710042 room 112, floor 1, building A2, standard workshop community, Xi'an Textile Industrial Park, Baqiao District, Xi'an City, Shaanxi Province Applicant after: Shaanxi bairuiheng Health Technology Co.,Ltd. Address before: 523808 room 10, 1st floor, building 1, Dongguan Taiwan Biotechnology cooperation center, No.1 Taoyuan Road, Taiwan hi tech park, Songshanhu hi tech Industrial Development Zone, Dongguan City, Guangdong Province Applicant before: DONGGUAN NATURAL SALUTEM HEALTH TECHNOLOGY CO.,LTD. |
|
| CB02 | Change of applicant information | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190402 |
|
| WD01 | Invention patent application deemed withdrawn after publication |