CN109528658A - A kind of compound probiotic freeze-dried powder - Google Patents
A kind of compound probiotic freeze-dried powder Download PDFInfo
- Publication number
- CN109528658A CN109528658A CN201811643131.6A CN201811643131A CN109528658A CN 109528658 A CN109528658 A CN 109528658A CN 201811643131 A CN201811643131 A CN 201811643131A CN 109528658 A CN109528658 A CN 109528658A
- Authority
- CN
- China
- Prior art keywords
- parts
- freeze
- powder
- probioctics
- compound probiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention relates to Freeze-dry Powder of Probioctics, more particularly to a kind of compound probiotic freeze-dried powder, raw material includes: modified Freeze-dry Powder of Probioctics 30-40 parts, 5-10 parts of stachyose, 5-15 parts of desalted whey powder, 5-15 parts of Whey Protein Concentrate powder, 0.5-0.9 parts of edible essence, 1-6 parts of prebiotics, 0.01-0.1 parts of D-sorbite by weight.The present invention can adjust intestinal flora, alleviate diarrhea and constipation, improve the immunity of body.
Description
Technical field
The present invention relates to Freeze-dry Powder of Probioctics, and in particular to a kind of compound probiotic freeze-dried powder.
Background technique
Existing research shows that the generation of gastric ulcer and helicobacter pylori have substantial connection.Stomach Helicobacter pylori can stick
Gastric epithelial cells are invested, and avoid being discharged with food by stomach；Hydrogen oxide enzyme, the proteolytic enzyme of helicobacter pylori secretion
And toxin etc. can damage gastric epithelial cells；In addition, helicobacter pylori, which also can pass through urea enzyme hydrolysis urea, generates ammonia,
" ammonia cloud " protective layer is formed, around thallus to resist the bactericidal effect of gastric acid.
Antibiotic, but removing of the antibiotic to helicobacter pylori are mainly used to the treatment of helicobacter pylori at present
Effect is limited, and it can also inhibit or kill some beneficial bacteriums in gastrointestinal tract while killing harmful bacteria.Probiotics is
One kind active microorganism beneficial to host is colonized in human body intestinal canal, in reproductive system, has bacterium in maintenance host gastrointestinal tract
Group's ecological balance reduces pathogenic toxin to the multiple beneficials effect such as damage of gastrointestinal tract.Therefore, pylorus is treated using probiotics
Gastric ulcer caused by pylori is the hot spot studied at present.
Summary of the invention
Technical problems based on background technology, the invention proposes a kind of compound probiotic freeze-dried powders.Energy of the present invention
It enough adjusts intestinal flora, alleviate diarrhea and constipation, improve the immunity of body.
A kind of compound probiotic freeze-dried powder proposed by the present invention, raw material include: modified Freeze-dry Powder of Probioctics by weight
30-40 parts, 5-10 parts of stachyose, 5-15 parts of desalted whey powder, 5-15 parts of Whey Protein Concentrate powder, 0.5-0.9 parts of edible essence,
1-6 parts of prebiotics, 0.01-0.1 parts of D-sorbite.
Preferably, raw material includes: modified Freeze-dry Powder of Probioctics 32-38 parts, 6-8 parts of stachyose, desalination cream by weight
Clear 8-12 parts of powder, 7-13 parts of Whey Protein Concentrate powder, 0.6-0.8 parts of edible essence, 2-5 parts of prebiotics, D-sorbite 0.03-
0.07 part.
Preferably, the modified Freeze-dry Powder of Probioctics is prepared according to following technique: Freeze-dry Powder of Probioctics being carried out true
Sky is dry, is then uniformly mixed with microcrystal cellulose powder, grinds, and obtains modified Freeze-dry Powder of Probioctics.
Preferably, the mass ratio of the Freeze-dry Powder of Probioctics and microcrystal cellulose powder is 1:0.5-0.7.
Preferably, in the vacuum drying operation, vacuum degree 0.09-2MPa, drying temperature is 30-45 DEG C, dry
Time is 25-30h.
Preferably, the granularity of the microcrystal cellulose powder is 5-10um.
Preferably, the speed of the grinding is 80-95r/min, time 4-8min.
Preferably, the probiotics is made of animal bifidobacteria and Lactobacillus rhamnosus.
The present invention is conventionally prepared.
Raw material of the invention includes modified Freeze-dry Powder of Probioctics, stachyose, desalted whey powder, Whey Protein Concentrate powder, food
It is reasonably combined with essence, prebiotics, D-sorbite, intestinal flora can be adjusted, alleviate diarrhea and constipation, improve exempting from for body
Epidemic disease power.Grinding modification is carried out to major ingredient ingredient Freeze-dry Powder of Probioctics, itself and microcrystal cellulose powder are ground under certain grinding rate
Certain time is ground, in grinding modifying process, some small particles of microcrystal cellulose powder can be adsorbed onto the big of Freeze-dry Powder of Probioctics
Particle surface, on the one hand crystallite can be made under the action of grinding machinery power by reducing Freeze-dry Powder of Probioctics and extraneous contact area
Attachment of the cellulose powder small particles on Freeze-dry Powder of Probioctics more closely, while can also make Freeze-dry Powder of Probioctics rupture, deformation,
Freeze-dry Powder of Probioctics even can because stress generate thermal energy cause surface to be melted, promote the biggish microcrystal cellulose powder of some partial sizes with
Adhesion, chimeric, form complicated micromorphology；On the other hand, Freeze-dry Powder of Probioctics or established compound particle can also be made
It is broken, generate new section；Further, since there are a small amount of small particles in Freeze-dry Powder of Probioctics, grinding modifying process can also be generated
Part small particles, grinding modifier still have certain hygroscopicity in pulverulence, can be by subsequent granulation link come further
Specific surface area is reduced, improves the hygroscopicity of Freeze-dry Powder of Probioctics, and then extend the shelf-life of the invention, optimizes effect of the invention
Fruit.
Specific embodiment
In the following, technical solution of the present invention is described in detail by specific embodiment.
Embodiment 1
A kind of compound probiotic freeze-dried powder, raw material include: 30 parts of modified Freeze-dry Powder of Probioctics, stachyose 10 by weight
Part, 5 parts of desalted whey powder, 15 parts of Whey Protein Concentrate powder, 0.5 part of edible essence, 6 parts of prebiotics, 0.01 part of D-sorbite.
Embodiment 2
A kind of compound probiotic freeze-dried powder, raw material include: 40 parts of modified Freeze-dry Powder of Probioctics, stachyose 5 by weight
Part, 15 parts of desalted whey powder, 5 parts of Whey Protein Concentrate powder, 0.9 part of edible essence, 1 part of prebiotics, 0.1 part of D-sorbite；
Wherein, the modified Freeze-dry Powder of Probioctics is prepared according to following technique: Freeze-dry Powder of Probioctics is carried out vacuum
It is dry, it is then uniformly mixed, grinds with microcrystal cellulose powder, obtain modified Freeze-dry Powder of Probioctics.
Embodiment 3
A kind of compound probiotic freeze-dried powder, raw material include: 35 parts of modified Freeze-dry Powder of Probioctics, stachyose 7 by weight
Part, 10 parts of desalted whey powder, 10 parts of Whey Protein Concentrate powder, 0.7 part of edible essence, 4 parts of prebiotics, 0.05 part of D-sorbite；
Wherein, the modified Freeze-dry Powder of Probioctics is prepared according to following technique: Freeze-dry Powder of Probioctics is carried out vacuum
It is dry, it is then uniformly mixed, grinds with microcrystal cellulose powder, obtain modified Freeze-dry Powder of Probioctics；
The mass ratio of the Freeze-dry Powder of Probioctics and microcrystal cellulose powder is 1:0.6；
In the vacuum drying operation, vacuum degree 0.8MPa, drying temperature is 40 DEG C, drying time 27h；
The granularity of the microcrystal cellulose powder is 7um；
The speed of the grinding is 90r/min, time 6min；
The probiotics is made of animal bifidobacteria and Lactobacillus rhamnosus.
Embodiment 4
A kind of compound probiotic freeze-dried powder, raw material include: 32 parts of modified Freeze-dry Powder of Probioctics, stachyose 8 by weight
Part, 8 parts of desalted whey powder, 13 parts of Whey Protein Concentrate powder, 0.6 part of edible essence, 5 parts of prebiotics, 0.03 part of D-sorbite；
Wherein, the modified Freeze-dry Powder of Probioctics is prepared according to following technique: Freeze-dry Powder of Probioctics is carried out vacuum
It is dry, it is then uniformly mixed, grinds with microcrystal cellulose powder, obtain modified Freeze-dry Powder of Probioctics；
The mass ratio of the Freeze-dry Powder of Probioctics and microcrystal cellulose powder is 1:0.7；
In the vacuum drying operation, vacuum degree 0.09MPa, drying temperature is 45 DEG C, drying time 25h；
The granularity of the microcrystal cellulose powder is 10um；
The speed of the grinding is 80r/min, time 8min；
The probiotics is made of animal bifidobacteria and Lactobacillus rhamnosus.
Embodiment 5
A kind of compound probiotic freeze-dried powder, raw material include: 38 parts of modified Freeze-dry Powder of Probioctics, stachyose 6 by weight
Part, 12 parts of desalted whey powder, 7 parts of Whey Protein Concentrate powder, 0.8 part of edible essence, 2 parts of prebiotics, 0.07 part of D-sorbite；
Wherein, the modified Freeze-dry Powder of Probioctics is prepared according to following technique: Freeze-dry Powder of Probioctics is carried out vacuum
It is dry, it is then uniformly mixed, grinds with microcrystal cellulose powder, obtain modified Freeze-dry Powder of Probioctics；
The mass ratio of the Freeze-dry Powder of Probioctics and microcrystal cellulose powder is 1:0.5；
In the vacuum drying operation, vacuum degree 2MPa, drying temperature is 30 DEG C, drying time 30h；
The granularity of the microcrystal cellulose powder is 5um；
The speed of the grinding is 95r/min, time 4min；
The probiotics is made of animal bifidobacteria and Lactobacillus rhamnosus.
Test example 1
Freeze-dry Powder of Probioctics and the modification that the equilibrium water conten of thick 3mm is respectively put into the flat weighing bottle of constant weight are prebiotic
Weighing bottle is put into the drier equipped with sodium chloride supersaturated solution, opens weighing bottle by bacterium freeze-dried powder, accurately weighed quality
Lid saves under the conditions of constant temperature and humidity, and timing (8h, for 24 hours, 72h) it takes out, accurately weighed quality calculates moisture absorption according to the following formula
Rate: quality × 100% before hydroscopicity=(quality before quality-moisture absorption after moisture absorption)/moisture absorption.As a result as shown in the table:
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (8)
1. a kind of compound probiotic freeze-dried powder, which is characterized in that its raw material includes: modified Freeze-dry Powder of Probioctics 30- by weight
40 parts, 5-10 parts of stachyose, 5-15 parts of desalted whey powder, 5-15 parts of Whey Protein Concentrate powder, 0.5-0.9 parts of edible essence, benefit
Raw 1-6 parts of member, 0.01-0.1 parts of D-sorbite.
2. compound probiotic freeze-dried powder according to claim 1, which is characterized in that its raw material includes: modified benefit by weight
32-38 parts of raw bacterium freeze-dried powder, 6-8 parts of stachyose, 8-12 parts of desalted whey powder, 7-13 parts of Whey Protein Concentrate powder, edible essence
0.6-0.8 parts, 2-5 parts of prebiotics, 0.03-0.07 parts of D-sorbite.
3. compound probiotic freeze-dried powder according to claim 2, which is characterized in that the modified Freeze-dry Powder of Probioctics is according to such as
Prepared by lower technique: Freeze-dry Powder of Probioctics being dried in vacuo, is then uniformly mixed with microcrystal cellulose powder, grinds, obtains
To modified Freeze-dry Powder of Probioctics.
4. compound probiotic freeze-dried powder according to claim 3, which is characterized in that the Freeze-dry Powder of Probioctics and microcrystalline cellulose
The mass ratio of plain powder is 1:0.5-0.7.
5. compound probiotic freeze-dried powder according to claim 3, which is characterized in that in the vacuum drying operation, vacuum
Degree is 0.09-2MPa, and drying temperature is 30-45 DEG C, drying time 25-30h.
6. compound probiotic freeze-dried powder according to claim 3, which is characterized in that the granularity of the microcrystal cellulose powder is 5-
10um。
7. compound probiotic freeze-dried powder according to claim 3, which is characterized in that the speed of the grinding is 80-95r/
Min, time 4-8min.
8. compound probiotic freeze-dried powder according to claim 1 or claim 2, which is characterized in that the probiotics is by animal bifid bar
Bacterium and Lactobacillus rhamnosus composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811643131.6A CN109528658A (en) | 2018-12-29 | 2018-12-29 | A kind of compound probiotic freeze-dried powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811643131.6A CN109528658A (en) | 2018-12-29 | 2018-12-29 | A kind of compound probiotic freeze-dried powder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109528658A true CN109528658A (en) | 2019-03-29 |
Family
ID=65831517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811643131.6A Pending CN109528658A (en) | 2018-12-29 | 2018-12-29 | A kind of compound probiotic freeze-dried powder |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109528658A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112772927A (en) * | 2020-12-31 | 2021-05-11 | 重庆第二师范学院 | Probiotic freeze-dried powder |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130273155A1 (en) * | 2010-07-09 | 2013-10-17 | Master Supplements, Inc. | Prebiotic Compositions for use with Probiotics to increase probiotic growth rate and activity |
| CN104799392A (en) * | 2015-05-19 | 2015-07-29 | 河北金木药业集团有限公司 | Fruit-vegetable solid beverage with function of coordinating intestines and stomach and preparation method for fruit-vegetable solid beverage |
| CN106943453A (en) * | 2017-05-27 | 2017-07-14 | 贵阳中医学院 | It is a kind of to treat medicine of diabete peripheral herve pathology and preparation method thereof |
| CN107835641A (en) * | 2015-06-08 | 2018-03-23 | 科.汉森有限公司 | Glyceryl rubber candy and foam confectionary products with probiotics |
-
2018
- 2018-12-29 CN CN201811643131.6A patent/CN109528658A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130273155A1 (en) * | 2010-07-09 | 2013-10-17 | Master Supplements, Inc. | Prebiotic Compositions for use with Probiotics to increase probiotic growth rate and activity |
| CN104799392A (en) * | 2015-05-19 | 2015-07-29 | 河北金木药业集团有限公司 | Fruit-vegetable solid beverage with function of coordinating intestines and stomach and preparation method for fruit-vegetable solid beverage |
| CN107835641A (en) * | 2015-06-08 | 2018-03-23 | 科.汉森有限公司 | Glyceryl rubber candy and foam confectionary products with probiotics |
| CN106943453A (en) * | 2017-05-27 | 2017-07-14 | 贵阳中医学院 | It is a kind of to treat medicine of diabete peripheral herve pathology and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 孙淑萍等: "中药防潮一样不能少", 《中国医药报》 * |
| 杨小妹: "不同辅料对十全大补汤浸膏粉吸湿性的影响", 《江西中医学院学报》 * |
| 罗世江: "不同辅料对中药全浸膏制剂防潮效果探讨", 《中国医药导刊》 * |
| 金颖成等: "数学模型参数在中成药固体制剂防潮中的应用", 《药物研发》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112772927A (en) * | 2020-12-31 | 2021-05-11 | 重庆第二师范学院 | Probiotic freeze-dried powder |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105996051B (en) | Comprising lactic acid bacteria and protection novel compositions of agents | |
| CN105685891B (en) | High-resistance starch instant whole lotus root starch and preparation method thereof | |
| CN111109492A (en) | Functional collagen peptide probiotic solid beverage and preparation method thereof | |
| CN110403198B (en) | Probiotic soft capsule and preparation method thereof | |
| CN112088967A (en) | Probiotic gel candy suitable for infants and preparation method thereof | |
| CN104996737B (en) | A kind of coating preparation method of fodder acidulant | |
| CN109528658A (en) | A kind of compound probiotic freeze-dried powder | |
| CN105614783B (en) | Yam bean dietary fiber powder with prebiotics function and preparation method thereof | |
| CN110810517A (en) | Multi-probiotic solid beverage and preparation method thereof | |
| JP2002320473A (en) | Method for producing doubly coated lactobacillus bulk powder utilizing protein and polysaccharide | |
| CN105010760B (en) | A kind of wide spectrum feed montmorillonite takes off mould dose and preparation method thereof and application method | |
| CN105725127B (en) | Water chestnut dietary fiber powder with prebiotics function and preparation method thereof | |
| CN110122778A (en) | A kind of rice flour manufacturing method | |
| CN106359651A (en) | Solid beverage composition containing lactoprotein and preparation method thereof | |
| CN109393043A (en) | A kind of fermented type probiotic formulation goat milk powder and preparation method thereof | |
| CN114568700A (en) | Particle embedded with probiotics and preparation method thereof | |
| CN110251474B (en) | Preparation method of starch-based large intestine targeting double-layer probiotic tablet | |
| KR20100129036A (en) | Method for manufacturing fermentation organic calcium | |
| CN114947035A (en) | Probiotic solid beverage using edible fungus superfine powder as prebiotics and preparation method thereof | |
| JP2023098030A (en) | Composition for promoting proliferation of akkermansia muciniphila comprising dietary fiber | |
| RU2438345C1 (en) | Silicon-containing composition of rice husks and its production method | |
| Thamacharoensuk et al. | Optimization of microencapsulated Lactobacillus rhamnosus GG from whey protein and glutinous rice starch by spray drying | |
| Yaqoob et al. | Microencapsulation of Clostridium tyrobutyricum by Spray drying Method and Its Characteristics in-vitro. | |
| CN109619299A (en) | One boar probiotics feed and preparation method thereof | |
| CN109527097A (en) | A kind of lactic acid bacteria goat milk tablet and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190329 |
|
| RJ01 | Rejection of invention patent application after publication |