CN109528566A - A kind of Traditional Chinese medicine bacteriostatic hand cleanser and preparation method thereof - Google Patents
A kind of Traditional Chinese medicine bacteriostatic hand cleanser and preparation method thereof Download PDFInfo
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- CN109528566A CN109528566A CN201910058669.9A CN201910058669A CN109528566A CN 109528566 A CN109528566 A CN 109528566A CN 201910058669 A CN201910058669 A CN 201910058669A CN 109528566 A CN109528566 A CN 109528566A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Abstract
The purpose of the present invention is to provide a kind of Traditional Chinese medicine bacteriostatic hand cleanser of good antimicrobial effect, it is characterized in that, contain following ingredient by percentage to the quality: obakunone 0.4%-1.0%, Forsythia suspense essential oil 1.2%-1.8%, Rhizoma Atractylodis Macrocephalae essential oil 1.5%-2.3%, preservative 0.1%-0.4%, solubilizer 0.3%-0.8%, moisturizer 1.2%-3%, corrigent 0.1%-0.5%, foaming agent 4%-8%, foaming agent 4%-10%, metal ion chelation agent 0.05%-0.4%, surplus is deionized water.The Traditional Chinese medicine bacteriostatic hand cleanser has fungistatic effect more better than the bacteriostatic hand sanitizer containing essential oil of traditional Chinese medicine of routine, in addition also has the advantages that low irritant, high-cleanness ability, therefore is suitble to promote the use of, and has good application value.
Description
Technical field
The invention belongs to daily necessities field, it is related to a kind of hand cleanser and preparation method thereof, and in particular to a kind of Traditional Chinese medicine bacteriostatic
Hand cleanser and preparation method thereof.
Background technique
Hand cleanser is a kind of common daily necessities, for cleaning hand.
In order to reach the antibacterial effect of better cleaning effect, especially degerming, occur in the prior art some antibacterial
Type hand cleanser enables user preferably to remove bacterium while washing one's hands wherein being added to a certain amount of bacteriostatic agent.
Currently, common bacteriostatic agent mainly has phenols, boric acid class etc. in daily necessities, in addition, Common Preservatives such as nipalgin
Esters, conventional sterilants such as sulphur etc. also has more application in daily necessities field as bacteriostatic agent.However, these ingredients are mostly to change
It learns synthetic ingredient or has natural component compared with strong and stimulating, and user is unwilling using containing excessive synthetic ingredient or tool
Daily necessities excitatory.
For this purpose, in recent years, the research staff of daily necessities field focuses on the natural antipathogenic composition in exploitation source more, such as extracts
From the essential oil antipathogenic composition etc. of various traditional Chinese medicines.But these usual bacteriostatic activities of essential oil extracted are lower, it is difficult to reach
Ideal fungistatic effect.
Summary of the invention
To solve the above problems, providing a kind of better Traditional Chinese medicine bacteriostatic hand cleanser of fungistatic effect, the present inventor couple
Different types of essential oil of traditional Chinese medicine, combination and its effect are studied, and discovery is shared when obakunone and Forsythia suspense essential oil, Rhizoma Atractylodis Macrocephalae essential oil
When there is facilitation to the fungistatic effects of two kinds of essential oils so that better antibacterial effect can be generated after three kinds of ingredients mixing
Fruit.
Based on above-mentioned discovery, the antibacterial hand sanitizer containing obakunone, Forsythia suspense essential oil and Rhizoma Atractylodis Macrocephalae essential oil is inventors herein proposed.
Specifically, the present invention provides a kind of Traditional Chinese medicine bacteriostatic hand cleanser, which is characterized in that contains following ingredient by percentage to the quality:
Obakunone 0.4%-1.0%, Forsythia suspense essential oil 1.2%-1.8%, Rhizoma Atractylodis Macrocephalae essential oil 1.5%-2.3%, preservative 0.1%-0.4%,
Solubilizer 0.3%-0.8%, moisturizer 1.2%-3%, corrigent 0.1%-0.5%, foaming agent 8%-18%, metal ion chela
Mixture 0.05%-0.4%, surplus are deionized water.
Traditional Chinese medicine bacteriostatic hand cleanser provided by the invention, can also have such technical characteristic, wherein preservative is sorb
Acid, solubilizer are polyoxyethylene sorbitan monoleate, and moisturizer is glycerol, and corrigent is essence, and foaming agent includes empgen BB and coconut palm
Oleamide propyl betaine, metal ion chelation agent EDTA-4Na.
Traditional Chinese medicine bacteriostatic hand cleanser provided by the invention, can also have such technical characteristic, empgen BB
Mass percent is 4%-8%, and the mass percent of Cocoamidopropyl betaine is 4%-10%.
Traditional Chinese medicine bacteriostatic hand cleanser provided by the invention, can also have such technical characteristic, wherein the quality of obakunone
Percentage is 0.8%, and the mass percent of Forsythia suspense essential oil is 1.6%, and the mass percent of Rhizoma Atractylodis Macrocephalae essential oil is 2.1%.
The present invention also provides the preparation methods of above-mentioned Traditional Chinese medicine bacteriostatic hand cleanser, which comprises the steps of:
Step S1, deionized water is put into clean container, be added while stirring at room temperature preservative, solubilizer, moisturizer,
A phase is made until being completely dissolved, being uniformly dispersed in corrigent, foaming agent and metal ion chelation agent；Step S2, by obakunone,
A phase is added in Forsythia suspense essential oil and Rhizoma Atractylodis Macrocephalae essential oil, is stirred at room temperature uniformly, until forming stable clear solution system.Step S3,
Filtering is after being stored at room temperature the predetermined time to get Traditional Chinese medicine bacteriostatic hand cleanser.
The preparation method of Traditional Chinese medicine bacteriostatic hand cleanser provided by the invention, can also have such technical characteristic, wherein step
Rapid S1 and the revolving speed of the stirring in step S2 are 200 turns per minute.
The preparation method of Traditional Chinese medicine bacteriostatic hand cleanser provided by the invention, can also have such technical characteristic, wherein even
The preparation process for sticking up essential oil is as follows: weighing Weeping Forsythia Capsule and is placed in dry container, distillation watertight is added by the liquid-solid ratio of 12:1
After envelope, immersion 17h~19h, 120 DEG C of oil bath heatings extract 6h, the volatile oil distilled out；Oil be will volatilize using anhydrous ether
Extraction, and a small amount of anhydrous sodium sulfate absorbent drying is added, it is put in 4 DEG C of refrigerator after sealing overnight, Rotary Evaporators are used after filtering
Ether is evaporated, Forsythia suspense essential oil is obtained.
The preparation method of Traditional Chinese medicine bacteriostatic hand cleanser provided by the invention, can also have such technical characteristic, wherein white
The preparation process of art essential oil is as follows: it weighs Rhizoma Atractylodis Macrocephalae powder and is placed in drying receptacle, ethyl acetate is added by liquid-solid ratio 6:1, shake up,
Sealing, shady place disposed within, environment temperature control carries out impregnating between 22 DEG C -24 DEG C and every immersion 12h is ultrasonic
20min carries out obtaining leachate 3 times altogether；There are ethyl acetate, raffinate using rotating thin film decompression method recycling after leachate filtering
Body is added after a small amount of anhydrous sodium sulfate water removal dries, filters and obtains Rhizoma Atractylodis Macrocephalae essential oil.
Invention action and effect
The Traditional Chinese medicine bacteriostatic hand cleanser provided according to the present invention, due to the Cortex Phellodendri for being 0.4%-1.0% containing mass percent
The Rhizoma Atractylodis Macrocephalae essential oil of ketone, the Forsythia suspense essential oil of 1.2%-1.8% and 1.5%-2.3%, wherein obakunone can promote Forsythia suspense essential oil
And the bacteriostasis of Rhizoma Atractylodis Macrocephalae essential oil, so that fungistatic effect gets a promotion when three is used in conjunction with, and therefore, Traditional Chinese medicine bacteriostatic of the invention
Hand cleanser has fungistatic effect more better than the bacteriostatic hand sanitizer containing essential oil of traditional Chinese medicine of routine.In addition, Traditional Chinese medicine bacteriostatic of the invention
Hand cleanser also has the advantages that low irritant, high-cleanness ability, therefore is suitble to promote the use of, and has good application value.
Specific embodiment
Illustrate a specific embodiment of the invention with reference to embodiments.
In following each embodiments, hand cleanser is all made of following steps preparation:
Step S1, deionized water is put into clean container, is added while stirring (200 turns per minute) at room temperature
Sorbic acid (as preservative), polyoxyethylene sorbitan monoleate (as solubilizer, for increasing essential oil dissolution, hereinafter referred to as polysorbate),
Glycerol (as moisturizer), essence (as corrigent), empgen BB (as foaming agent), cocamidopropyl propyl amide beet
Alkali (being equally used as foaming agent) and EDTA-4Na (as metal ion chelation agent), until be completely dissolved, be uniformly dispersed, obtained A
Phase；
A phase is added in obakunone, Forsythia suspense essential oil and Rhizoma Atractylodis Macrocephalae essential oil by step S2, be stirred at room temperature (magnetic stirring apparatus, often
200 turns of minute) uniformly, until forming stable clear solution system.
Step S3 is stored at room temperature and is filtered afterwards to get hand cleanser for 24 hours.
Forsythia suspense essential oil used in the above process and Rhizoma Atractylodis Macrocephalae essential oil are the self-control of inventor laboratory, obakunone and other examinations
Agent is general commercial sources buying gained.
The preparation process of Forsythia suspense essential oil is as follows: weighing the Weeping Forsythia Capsule 20g of 30 meshes, is placed in dry 1L round-bottomed flask
In, after distilled water 240mL sealing is added, is impregnated 18h by liquid-solid ratio 12:1, volatile oil extractor and condenser pipe have been reconnected,
Instrument is placed on the magnetic stirring apparatus of temperature-controllable, and 120 DEG C of oil bath heatings extract 6h.The volatile oil distilled out uses anhydrous ether
Extraction, and a small amount of anhydrous sodium sulfate absorbent drying is added, it is put in 4 DEG C of refrigerator after sealing overnight, Rotary Evaporators are used after filtering
Ether is evaporated to get glassy yellow oily liquids, as Forsythia suspense essential oil is arrived.
By technological parameter comparative experiments, present inventor determined that the optimum process condition of Forsythia suspense essential oil are as follows: impregnate
Time 18h, liquid-solid ratio 12:1, extraction time 6h, the yield highest of Forsythia suspense essential oil, is 1.67% with this condition.
The preparation process of Rhizoma Atractylodis Macrocephalae essential oil is as follows: weighing the Rhizoma Atractylodis Macrocephalae powder 30g of 20 meshes, is placed in dry 500mL conical flask
In, ethyl acetate 180mL is added by liquid-solid ratio 6:1, shakes up, seal, shady place disposed within, environment temperature is controlled in 22-24
DEG C, every immersion 12h, ultrasonic 20min carry out obtaining leachate 3 times altogether.Using rotating thin film decompression method recycling after leachate filtering
There is ethyl acetate, remaining liq is added after a small amount of anhydrous sodium sulfate water removal dries, filters and obtains gold oil liquid, as
Rhizoma Atractylodis Macrocephalae essential oil.
By technological parameter comparative experiments, present inventor determined that the optimum process condition of Rhizoma Atractylodis Macrocephalae essential oil are as follows: extraction
Method organic solvent is ethyl acetate, and liquid-solid ratio 6:1, environment temperature is 24 DEG C, and every soaking time 12h, ultrasonic 20min carry out 3 altogether
Secondary, the yield highest of Rhizoma Atractylodis Macrocephalae essential oil, is 2.83% with this condition.
In addition, in the hand cleanser that the above process is mainly the process of physical mixed, therefore finally obtains each ingredient content
Ratio is equal to its additive amount.During described below, each component content refers both to its additive amount, and degree refers both to quality
Degree.Obviously, which also corresponds to mass percentage content of each ingredient in hand cleanser finished product.
<embodiment 1>
Embodiment 1 is that the preparation of Traditional Chinese medicine bacteriostatic hand cleanser of the invention is tested.
In embodiment 1, the content of each ingredient are as follows: obakunone 0.8%, Forsythia suspense essential oil 1.6%, Rhizoma Atractylodis Macrocephalae essential oil 2.1%, sorb
Acid 0.3%, polysorbate 0.4%, glycerol 2%, essence 0.2%, empgen BB 4.6%, cocamidopropyl propyl amide beet
Alkali 5.8%, EDTA-4Na 0.12%, surplus are deionized water.
<embodiment 2>
Embodiment 2 is that the preparation of Traditional Chinese medicine bacteriostatic hand cleanser of the invention is tested.
In embodiment 2, the content of each ingredient are as follows: obakunone 0.8%, Forsythia suspense essential oil 1.6%, Rhizoma Atractylodis Macrocephalae essential oil 2.1%, sorb
Acid 0.3%, polysorbate 0.4%, glycerol 2%, essence 0.2%, empgen BB 4.6%, cocamidopropyl propyl amide beet
Alkali 5.8%, EDTA-4Na 0.12%, surplus are deionized water.
<embodiment 3>
Embodiment 3 is that the preparation of Traditional Chinese medicine bacteriostatic hand cleanser of the invention is tested.
In embodiment 3, the content of each ingredient are as follows: obakunone 0.6%, Forsythia suspense essential oil 1.7%, Rhizoma Atractylodis Macrocephalae essential oil 1.8%, sorb
Acid 0.2%, polysorbate 0.3%, glycerol 1.8%, essence 0.3%, empgen BB 6.3%, cocamidopropyl propyl amide sweet tea
Dish alkali 6.3%, EDTA-4Na 0.18%, surplus are deionized water.
Following comparative example is the comparative experiments of hand cleanser.Below in each comparative example, the preparation process of hand cleanser with it is above-mentioned
Embodiment is identical, i.e., the ingredient other than antipathogenic composition (essential oil) is first mixed and made into A phase, and A phase then is added in antipathogenic composition, is stirred
It mixes, filter obtained hand cleanser.
<comparative example 1>
By percentage to the quality, the hand cleanser of comparative example 1 of the invention contains following ingredient: Forsythia suspense essential oil 1.6%, Rhizoma Atractylodis Macrocephalae
Essential oil 2.1%, sorbic acid 0.3%, polysorbate 0.4%, glycerol 2%, essence 0.2%, empgen BB 4.6%, coconut palm
Oleamide propyl betaine 5.8%, EDTA-4Na 0.12%, surplus are deionized water.
<comparative example 2>
By percentage to the quality, the hand cleanser of comparative example 2 of the invention contains following ingredient: obakunone 0.8%, Rhizoma Atractylodis Macrocephalae essence
Oil 2.1%, sorbic acid 0.3%, polysorbate 0.4%, glycerol 2%, essence 0.2%, empgen BB 4.6%, cocounut oil
Amido propyl betaine 5.8%, EDTA-4Na 0.12%, surplus are deionized water.
<comparative example 3>
By percentage to the quality, the hand cleanser of comparative example 3 of the invention contains following ingredient: obakunone 0.8%, Fructus Forsythiae essence
Oil 1.6%, sorbic acid 0.3%, polysorbate 0.4%, glycerol 2%, essence 0.2%, empgen BB 4.6%, cocounut oil
Amido propyl betaine 5.8%, EDTA-4Na 0.12%, surplus are deionized water.
<comparative example 4>
By percentage to the quality, the hand cleanser of comparative example 4 of the invention contains following ingredient: obakunone 0.8%, sorbic acid
0.3%, polysorbate 0.4%, glycerol 2%, essence 0.2%, empgen BB 4.6%, Cocoamidopropyl betaine
5.8%, EDTA-4Na 0.12%, surplus are deionized water.
<comparative example 5>
By percentage to the quality, the hand cleanser of comparative example 5 of the invention contains following ingredient: phenol 0.3%, sorbic acid
0.3%, polysorbate 0.4%, glycerol 2%, essence 0.2%, empgen BB 4.6%, Cocoamidopropyl betaine
5.8%, EDTA-4Na 0.12%, surplus are deionized water.
<comparative example 6>
By percentage to the quality, the hand cleanser of comparative example 6 of the invention contains following ingredient: phenol 0.3%, obakunone
0.8%, sorbic acid 0.3%, polysorbate 0.4%, glycerol 2%, essence 0.2%, empgen BB 4.6%, cocounut oil acyl
Amine propyl betaine 5.8%, EDTA-4Na 0.12%, surplus are deionized water.
<comparative example 7>
By percentage to the quality, the hand cleanser of comparative example 7 of the invention contains following ingredient: phenol 0.3%, Forsythia suspense essential oil
1.6%, Rhizoma Atractylodis Macrocephalae essential oil 2.1%, sorbic acid 0.3%, polysorbate 0.4%, glycerol 2%, essence 0.2%, dodecyl beet
Alkali 4.6%, Cocoamidopropyl betaine 5.8%, EDTA-4Na 0.12%, surplus are deionized water.
The action and effect of embodiment
Illustrate embodiment of the present invention system below in conjunction with the performance test results to the various embodiments described above and comparative example progress
The action and effect of the Traditional Chinese medicine bacteriostatic hand cleanser obtained.
1. bacteriostatic experiment
According to appendix C 4 in GB15797-2002 " Disposable Sanitary Accessory sanitary standard ", " stripping property resists (suppression) bacterium to produce
Product bacteriostasis property test method ", the antibacterial for detecting the hand cleanser of the various embodiments described above and comparative example using suspension quantitative method are horizontal.
Wherein, bacteria to be tested be staphylococcus aureus (ATCC 6538), Escherichia coli (ATCC 25922), white read
As a result pearl bacterium (ATCC 10231) three classes bacterium, detectable concentration 1:100, action time 20min see the table below 1.
The bacteriostasis property test result of the hand cleanser of 1 embodiment of table and comparative example
| Group | Staphylococcus aureus inhibiting rate (%) | Escherichia coli inhibiting rate (%) | Candida albicans inhibiting rate (%) |
| Embodiment 1 | 98.73 | 99.24 | 99.02 |
| Embodiment 2 | 97.85 | 98.19 | 99.27 |
| Embodiment 3 | 98.23 | 99.08 | 98.15 |
| Comparative example 1 | 52.36 | 55.47 | 54.29 |
| Comparative example 2 | 91.08 | 88.49 | 86.21 |
| Comparative example 3 | 92.41 | 90.32 | 89.77 |
| Comparative example 4 | 84.51 | 80.27 | 81.38 |
| Comparative example 5 | 85.48 | 78.26 | 78.55 |
| Comparative example 6 | 88.92 | 86.37 | 83.04 |
| Comparative example 7 | 86.03 | 79.95 | 80.06 |
It can be seen directly that, the hand cleanser of embodiment 1- embodiment 3 all has good fungistatic effect, to gold from table 1
Staphylococcus aureus, Escherichia coli and Candida albicans these three common bacterias inhibiting rate reach 97% or more.
Embodiment 1 and comparative example 1 are compared as can be seen that Forsythia suspense essential oil and Rhizoma Atractylodis Macrocephalae are smart when without using obakunone
Even if oil is applied in combination, fungistatic effect is also poor.
Embodiment 1 and comparative example 1, comparative example 2, comparative example 3 are compared respectively as can be seen that when by Forsythia suspense essential oil with
When obakunone is mixed or Rhizoma Atractylodis Macrocephalae essential oil is mixed with obakunone, 90% or so can also be reached to the inhibiting rate of three kinds of bacteriums, said
Bright obakunone all has facilitation to the fungistatic effect of both essential oils.
Comparative example 4, comparative example 5 are compared as can be seen that 0.8% obakunone and 0.3% phenol have almost
Identical fungistatic effect；Further, embodiment 1 and comparative example 7 are compared into obakunone and Fructus Forsythiae as can be seen that 0.8%
Essential oil and the mixed bacteriostasis rate of Rhizoma Atractylodis Macrocephalae essential oil are apparently higher than 0.3% phenol and two kinds of mixed bacteriostasis rates of essential oil, explanation
Obakunone is not as the fungistatic effect and essential oil of its own to the facilitation of the fungistatic effect of Forsythia suspense essential oil, Rhizoma Atractylodis Macrocephalae essential oil
Fungistatic effect produces superposition.In addition, comparative example 4, comparative example 5 and comparative example 6 are compared it can also be seen that obakunone with
Bacteriostasis rate slightly improves after phenol mixing, illustrates after the mixing of two kinds of antibacterial substances that fungistatic effect produces superposition, but the effect
It improves different from facilitation effect of the obakunone for Forsythia suspense essential oil and Rhizoma Atractylodis Macrocephalae essential oil.Inventor speculates that this may be with Forsythia suspense essential oil
In the firpene constituents contained, the lactone constituents that contain in Rhizoma Atractylodis Macrocephalae essential oil it is related, obakunone not only itself has certain suppression
Bacterium effect, additionally it is possible to synergistic effect is generated with these active constituents, so that the bacteriostasis of two kinds of essential oils is significantly promoted, and it is general
Logical bacteriostatic agent phenol does not have this effect then.
In summary each embodiment and comparative example as a result, it follows that obakunone is to Forsythia suspense essential oil and white
The fungistatic effect of art essential oil has facilitation, and the facilitation is not as the simple superposition of fungistatic effect and generates
's.Therefore, obakunone and Forsythia suspense essential oil and Rhizoma Atractylodis Macrocephalae essential oil are used in mixed way to the fungistatic effect for being greatly improved hand cleanser products,
To reach the antibacterial standard of bacteriostatic hand sanitizer.
2. skin irritation test
This experiment is the skin irritation test carried out using the hand cleanser of embodiment 1- embodiment 3.
Detailed process are as follows: healthy adult university student 90 are enlisted, is randomly divided into 3 groups, every group of 30 people, everyone palm of the hand, the back of the hand
It is each to smear hand cleanser 1mL, it is covered with hospital gauze, and be fixed with nonirritant adhesive plaster.After smearing 3h, wash with water,
Removal of residue is removed, then 30min, 1h, 2h, 12h after removal, for 24 hours, observation local skin reaction when 48h.
The results show that 3 groups of subjects occur without skin adverse reaction, recipient site has no erythema, oedema, itch etc. no
Suitable symptom.Illustrate that the hand cleanser of embodiment 1- embodiment 3 is mild, safe, does not have skin irritation, be suitble to routine use.
3. washing effect is tested
This experiment is that the washing effect carried out using the hand cleanser and general commercially available hand cleanser of embodiment 1- embodiment 3 is tried
It tests.
Detailed process are as follows: enlist healthy adult university student 120, be randomly divided into 4 groups, every group of 30 people, respectively hand cleanser into
The evaluation of row cleaning ability and sensory evaluation.
Test is all made of own control, respectively draws the test zone of a 2cm*5cm in volunteer's palm of the hand, dorsal side,
The lipstick that upper area is 1cm*4cm is uniformly smeared in this region, cleaning process is using hand cleanser to be tested to beat at lipstick
Circle mode is light and slow rub and wash half a minute after, flowing water rinses.After washing, observes and clean effect and lipstick residual condition and recorded, mouth
It is red it is obvious removal be denoted as " effective ", lipstick removes more than half and is denoted as " effective ", lipstick remain it is more, substantially without significant change then
It is denoted as engineering noise.
The result of above-mentioned washing effect test see the table below 2.
The washing effect test result of 2 hand cleanser of table
| Group | It is effective | Effectively | In vain | Obvious effective rate (%) | Efficient (%) |
| Embodiment 1 | 30 | 0 | 0 | 100% | 100% |
| Embodiment 2 | 29 | 1 | 0 | 96.7% | 100% |
| Embodiment 3 | 28 | 2 | 0 | 93.3% | 100% |
| Commercial product | 26 | 4 | 0 | 86.7% | 100% |
In addition, compared with commercial product, the hand cleanser of embodiment 1- embodiment 3 is equal in use process through subject feedback
Butyrous can preferably be generated and enrich fine and smooth foam, feel is fine when washing, and strong detergency, irritation is low, rinses also more
Convenient, hand moistening effect is good after washing hand, there is moist effect to skin.
In summary the result of performance test is it is found that in the Traditional Chinese medicine bacteriostatic hand cleanser of embodiment, due to containing quality percentage
Than the Forsythia suspense essential oil of obakunone, 1.2%-1.8% for 0.4%-1.0% and the Rhizoma Atractylodis Macrocephalae essential oil of 1.5%-2.3%, wherein yellow
Cypress ketone can promote the bacteriostasis of Forsythia suspense essential oil and Rhizoma Atractylodis Macrocephalae essential oil, so that fungistatic effect gets a promotion when three is used in conjunction with,
Therefore, the Traditional Chinese medicine bacteriostatic hand cleanser of above-described embodiment has antibacterial effect preferably than the conventional bacteriostatic hand sanitizer containing essential oil of traditional Chinese medicine
Fruit.In addition, the Traditional Chinese medicine bacteriostatic hand cleanser of embodiment also has the advantages that low irritant, high-cleanness ability, therefore popularization is suitble to make
With with good application value.
Claims (8)
1. a kind of Traditional Chinese medicine bacteriostatic hand cleanser, which is characterized in that contain following ingredient by percentage to the quality:
Obakunone 0.4%-1.0%, Forsythia suspense essential oil 1.2%-1.8%, Rhizoma Atractylodis Macrocephalae essential oil 1.5%-2.3%, preservative 0.1%-
0.4%, solubilizer 0.3%-0.8%, moisturizer 1.2%-3%, corrigent 0.1%-0.5%, foaming agent 8%-18%, metal
Ion chelating agent 0.05%-0.4%, surplus are deionized water.
2. Traditional Chinese medicine bacteriostatic hand cleanser according to claim 1, it is characterised in that:
Wherein, the preservative is sorbic acid, and the solubilizer is polyoxyethylene sorbitan monoleate, and the moisturizer is glycerol, the flavoring
Agent is essence, and the foaming agent includes empgen BB and Cocoamidopropyl betaine, the metal ion chelation agent
For EDTA-4Na.
3. Traditional Chinese medicine bacteriostatic hand cleanser according to claim 2, it is characterised in that:
Wherein, the mass percent of the empgen BB is 4%-8%,
The mass percent of the Cocoamidopropyl betaine is 4%-10%.
4. Traditional Chinese medicine bacteriostatic hand cleanser according to claim 1, it is characterised in that:
Wherein, the mass percent of the obakunone is 0.8%,
The mass percent of the Forsythia suspense essential oil is 1.6%,
The mass percent of the Rhizoma Atractylodis Macrocephalae essential oil is 2.1%.
5. the preparation method of Traditional Chinese medicine bacteriostatic hand cleanser as described in claim 1, which comprises the steps of:
Step S1, deionized water is put into clean container, and preservative, solubilizer, guarantor is added while stirring at room temperature
A phase is made until being completely dissolved, being uniformly dispersed in humectant, corrigent, foaming agent and metal ion chelation agent；
Obakunone, Forsythia suspense essential oil and Rhizoma Atractylodis Macrocephalae essential oil are added the A phase, are stirred at room temperature uniformly by step S2, until being formed steady
Fixed clear solution system.
Step S3, filtering is after being stored at room temperature the predetermined time to get the Traditional Chinese medicine bacteriostatic hand cleanser.
6. the preparation method of Traditional Chinese medicine bacteriostatic hand cleanser according to claim 5, it is characterised in that:
Wherein, the revolving speed of the stirring in step S1 and step S2 is 200 turns per minute.
7. the preparation method of Traditional Chinese medicine bacteriostatic hand cleanser according to claim 5, it is characterised in that:
Wherein, the preparation process of the Forsythia suspense essential oil is as follows:
Weeping Forsythia Capsule is weighed to be placed in dry container, after distillation water-stop is added, is impregnated 17h~19h by the liquid-solid ratio of 12:1,
120 DEG C of oil bath heatings extract 6h, the volatile oil distilled out；
The volatile oil is extracted using anhydrous ether, and a small amount of anhydrous sodium sulfate absorbent drying is added, refrigerator 4 is put in after sealing
DEG C overnight, ether is used the rotary evaporator to vaporize after filtering, obtains the Forsythia suspense essential oil.
8. the preparation method of Traditional Chinese medicine bacteriostatic hand cleanser according to claim 5, it is characterised in that:
Wherein, the preparation process of the Rhizoma Atractylodis Macrocephalae essential oil is as follows:
It weighs Rhizoma Atractylodis Macrocephalae powder to be placed in drying receptacle, ethyl acetate is added by liquid-solid ratio 6:1, shakes up, seal, darkness disposed within
Place, environment temperature control carry out immersion and every immersion 12h ultrasound 20min between 22 DEG C -24 DEG C, altogether soaked for 3 times
Liquid out；
There is ethyl acetate using rotating thin film decompression method recycling after the leachate filtering, a small amount of anhydrous slufuric acid is added in remaining liq
Sodium water removal obtains the Rhizoma Atractylodis Macrocephalae essential oil after drying, filtering.
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| CN102423291A (en) * | 2011-12-30 | 2012-04-25 | 山西振东制药股份有限公司 | Traditional Chinese medicine antibiotic skincare hand cleanser and preparation method thereof |
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