CN109512737A - A kind of compact tender skin smoothing wrinkle eye cream of quantum and preparation method thereof - Google Patents

A kind of compact tender skin smoothing wrinkle eye cream of quantum and preparation method thereof Download PDF

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CN109512737A
CN109512737A CN201811384934.4A CN201811384934A CN109512737A CN 109512737 A CN109512737 A CN 109512737A CN 201811384934 A CN201811384934 A CN 201811384934A CN 109512737 A CN109512737 A CN 109512737A
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王瑞勤
王博
刘海敏
张旭升
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89Polysiloxanes
    • A61K8/891Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations

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Abstract

The invention discloses compact tender skin smoothing wrinkle eye creams of a kind of quantum and preparation method thereof, by Dimethicone Crosspolymer, cyclomethicone, PEG-10 Polydimethylsiloxane cross-linked polymer, dimethyl silicone polymer, C12-14 Pareth -7, ascorbic acid, allantoin, PEG-100 stearate, Cordyceps militaris extract, purple yu-lan (Magnolia liliflora) flower extract, Argireline, marine algae extract, C13-14 isoparaffin, ginseng root extract, Gotu Kola P.E, strand radix angelicae sinensis leaf/stem extraction, dipotassium glycyrrhizinate, laureth -7, Sodium Hyaluronate, butanediol, glycerol, vitamin E, potato pulp extract, Phenoxyethanol, epidermal growth factor, EDETATE SODIUM and acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters are handed over Linked polymer is prepared.Anti-wrinkle cream prepared by the present invention can promote skin to regenerate, and have the effect of smoothing wrinkle Firm, except spot water moistens.

Description

A kind of compact tender skin smoothing wrinkle eye cream of quantum and preparation method thereof
Technical field
The present invention relates to cosmetic technical field, the compact tender skin smoothing wrinkle eye cream of more particularly to a kind of quantum and its Preparation method.
Background technique
Mainstream of the skin care skin care products especially smoothing wrinkle class product in women daily life as consumption currently on the market, one As wrinkle mainly as caused by cutis laxa, because of dry thinning and skin corium the collagen of epidermal tissue and bullet Power fiber supplement is insufficient and attenuates, and loses mesh-supported power, skin follows the string, and is difficult to restore, to generate skin sagging, produce Raw wrinkle;And ultraviolet light irradiation can also promote to generate wrinkle, and the ultraviolet light in sunlight is the catalyst of eye skin aging, meeting Ocular angiogenesis expansion, ossein and the impaired reduction of elastic protein fiber are directly resulted in, enables skin quality be remarkably decreased, accelerates skin aging Process occurs wrinkle ahead of time;Habitual expression can make personal formation wrinkle of expressing one's feelings simultaneously, and when expression moves, muscle can be shunk, Long-term accumulation gets off, muscle tone enhancing, thus will form fold between muscle and skin when doing expression, forms expression line;With The growth at age, the cell of skin start lesion, aging, dry out, follow the string and gloss therewith, gradually become loose Dimness, wrinkle are more and more.
Therefore it provides one kind can nurse face and eye, skin cell regeneration is effectively facilitated, wrinkle is reduced Line, keeps the problem of skin care item in youth are those skilled in the art's urgent need to resolve here at firm skin.
Summary of the invention
In view of this, passing through anti-wrinkle cream the present invention provides compact tender skin smoothing wrinkle eye cream of a kind of quantum and preparation method thereof Interior high efficiency nutritious ingredient can not only promote cell differentiation and collage synthesis to improve skin elastic, and can also promote skin The metabolism of cuticula makes skin become more a softer and smoother touch, and can effectively facilitate skin regeneration, reaches and mitigates wrinkle, tight Cause the effect of skin;Dimethicone Crosspolymer has the function of that moment smooths eye part skin microgroove simultaneously.
To achieve the goals above, the invention provides the following technical scheme:
A kind of compact tender skin smoothing wrinkle eye cream of quantum, by forming following weight percentage components:
Preferably, the compact tender skin smoothing wrinkle eye cream of a kind of quantum, by forming following weight percentage components:
Further, the preparation method of the compact tender skin smoothing wrinkle eye cream of a kind of quantum, includes the following steps:
(1) by the Dimethicone Crosspolymer, cyclomethicone, vitamin of above-mentioned weight percent E, the ginseng of C12-14 Pareth -7, the C13-14 isoparaffin of 1/4 weight percent and 1/4 weight percent extracts Object is mixed, and is uniformly dispersed, and B phase is made;
(2) successively by PEG-10 Polydimethylsiloxane cross-linked polymer, the polydimethylsiloxanes of above-mentioned weight percent Alkane, Cordyceps militaris extract, ascorbic acid, allantoin, PEG-100 stearate, epidermal growth factor, dipotassium glycyrrhizinate, acetyl group Hexapeptide -8, marine algae extract, Gotu Kola P.E, the C13-14 isoparaffin of 1/4 weight percent and 1/4 weight percent Ginseng root extract is added in oily phase pot, and stirring is warming up to 80~85 DEG C, is completely dissolved the substance in oily phase pot uniformly, system At A phase;
(3) by acrylic acid (ester) class of above-mentioned weight percent/C10-30 alkylol acrylamide acid esters cross-linked polymer, fourth two The ginseng root extract of alcohol, the C13-14 isoparaffin of 1/4 weight percent and 1/4 weight percent mixes, and is uniformly dispersed C phase is made;
(4) successively by the water of above-mentioned weight percent, EDETATE SODIUM, glycerol, Sodium Hyaluronate, 1/4 weight percent The ginseng root extract of C13-14 isoparaffin and 1/4 weight percent is added in water phase pot, is stirring evenly and then adding into step (3) the C phase prepared, is warming up to 80~85 DEG C, is pumped into after being completely dissolved uniformly to emulsion pot, while stirring is warming up to 80~85 DEG C, D phase is made;
(5) B prepared by step (1) is added in the A phase that in oily phase pot prepared by step (2), stirring is warming up to 80~85 DEG C, after being completely dissolved uniformly, emulsion pot is evacuated to 0.015-0.03MPa, using negative pressure by the material in oily phase pot through filtering Net is slowly pumped into emulsion pot and is emulsified, while low whipping speed is homogeneous 15- under conditions of 2800-3500rpm/min 20min, open cycle water cools down after emulsification, and keeps vacuum to defoam, and E phase is made;
(6) E phase prepared by step (5) is cooled to 45~60 DEG C, sequentially adds the Qarnet orchid of above-mentioned weight percent Extract, strand radix angelicae sinensis leaf/stem extraction, laureth -7, potato pulp extract, Phenoxyethanol and step (4) system Standby D phase, under conditions of low whipping speed is 2800-3500rpm/min after homogeneous 3-8min, vacuumizing and defoaming is prepared into half Finished product;
(7) semi-finished product that step (6) is prepared are cooled to 38 DEG C, are obtained product anti-wrinkle cream after the assay was approved.
It can be seen via above technical scheme that compared with prior art, it is compact tender that the present disclosure provides a kind of quantum Skin smoothing wrinkle eye cream and preparation method thereof, anti-wrinkle cream prepared by the present invention is interior to be mentioned containing purple yu-lan (Magnolia liliflora) flower extract, strand radix angelicae sinensis leaf/stem Object, vitamin E, potato pulp extract, Sodium Hyaluronate, Argireline, marine algae extract, ginseng is taken to extract The efficient nutritional ingredient such as object, Gotu Kola P.E, can not only promote cell differentiation, repair the Skin Cell of lesion, promote carefully Born of the same parents' regeneration and collage synthesis improve skin elastic, and can also promote the metabolism of skin cuticula, become skin more It is a softer and smoother touch, while skin reduction is effectively facilitated, reach mitigation wrinkle, realizes the effect of compact skin;Present invention preparation simultaneously Anti-wrinkle cream in the Dimethicone Crosspolymer that contains there is moment to smooth eye, facial skin lines, it is compact flat Sliding eye pouch skin, allows the function of eye pouch and facial lines pop-off.
C13-14 isoparaffin is used in anti-wrinkle cream of the invention, this ingredient being capable of activating skin lesion, aging Cell, improve cell quantum liveness, and the high-frequency energy wave energy of quantum generates more than one hundred million time higher-order of oscillation per second, can be with It promotes blood circulation, reinforces cell metabolism, discharge dermal toxicity element and melanin, play desalination freckle, chloasma, sunburn Etc. the effect of various color spots;The situations such as acne, pachylosis, lark skin can be improved simultaneously.
Compact tender skin smoothing wrinkle eye cream of a kind of quantum provided by the invention and preparation method thereof, not only can make skin become fresh Work is full, promotes skin cell regeneration, makes smoothened face skin moment, compact, water profit and full;And the present invention designs Anti-wrinkle cream in ingredient it is scientific and reasonable, a large amount of biological light waves can be generated, when acting on skin, skin capillary can be made Expansion, cell liquid are effectively supplemented rapidly, and cell makes skin become more fair and tender and charming when obtaining nutritional supplementation.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical solution of the present invention is clearly and completely described, it is clear that institute The embodiment of description is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, Every other embodiment obtained by those of ordinary skill in the art without making creative efforts, belongs to this hair The range of bright protection.
The embodiment of the invention discloses compact tender skin smoothing wrinkle eye creams of a kind of quantum and preparation method thereof, by anti-wrinkle cream Effective component can not only promote differentiation and the collage synthesis of cell to improve the elastic force of skin, and can also promote skin angle The metabolism of matter layer makes skin become more a softer and smoother touch, and skin can be promoted to regenerate, and realizes the mesh of smoothing wrinkle, compact skin 's.
Embodiment 1
A kind of compact tender skin smoothing wrinkle eye cream of quantum, by forming following weight percentage components:
A kind of preparation method of the compact tender skin smoothing wrinkle eye cream of quantum, includes the following steps:
(1) by the Dimethicone Crosspolymer, cyclomethicone, vitamin of above-mentioned weight percent E, the ginseng of C12-14 Pareth -7, the C13-14 isoparaffin of 1/4 weight percent and 1/4 weight percent extracts Object is mixed, and is uniformly dispersed, and B phase is made;
(2) successively by PEG-10 Polydimethylsiloxane cross-linked polymer, the polydimethylsiloxanes of above-mentioned weight percent Alkane, Cordyceps militaris extract, ascorbic acid, allantoin, PEG-100 stearate, epidermal growth factor, dipotassium glycyrrhizinate, acetyl group Hexapeptide -8, marine algae extract, Gotu Kola P.E, the C13-14 isoparaffin of 1/4 weight percent and 1/4 weight percent Ginseng root extract is added in oily phase pot, and stirring is warming up to 80 DEG C, is completely dissolved the substance in oily phase pot uniformly, A is made Phase;
(3) by acrylic acid (ester) class of above-mentioned weight percent/C10-30 alkylol acrylamide acid esters cross-linked polymer, fourth two The ginseng root extract of alcohol, the C13-14 isoparaffin of 1/4 weight percent and 1/4 weight percent mixes, and is uniformly dispersed C phase is made;
(4) successively by the water of above-mentioned weight percent, EDETATE SODIUM, glycerol, Sodium Hyaluronate, 1/4 weight percent The ginseng root extract of C13-14 isoparaffin and 1/4 weight percent is added in water phase pot, is stirring evenly and then adding into step (3) the C phase prepared, is warming up to 80 DEG C, is pumped into after being completely dissolved uniformly to emulsion pot, while stirring is warming up to 80 DEG C, and D is made Phase;
(5) B prepared by step (1) is added in A phase prepared by step (2) in oily phase pot, stirring is warming up to 80 DEG C, complete After fully dissolved is uniform, emulsion pot is evacuated to 0.03MPa, and the material in oily phase pot is slowly pumped into cream through filter screen using negative pressure Change and emulsified in pot, while low whipping speed is homogeneous 15min under conditions of 3000rpm/min, open cycle after emulsification Water cooling, and vacuum is kept to defoam, E phase is made;
(6) E phase prepared by step (5) is cooled to 45 DEG C, the Qarnet orchid for sequentially adding above-mentioned weight percent is extracted D prepared by object, strand radix angelicae sinensis leaf/stem extraction, laureth -7, potato pulp extract, Phenoxyethanol and step (4) Phase, under conditions of low whipping speed is 3000rpm/min after homogeneous 3min, vacuumizing and defoaming is prepared into semi-finished product;
(7) semi-finished product that step (6) is prepared are cooled to 38 DEG C, are obtained product anti-wrinkle cream after the assay was approved.
Embodiment 2
A kind of compact tender skin smoothing wrinkle eye cream of quantum, by forming following weight percentage components:
A kind of preparation method of the compact tender skin smoothing wrinkle eye cream of quantum, includes the following steps:
(1) by the Dimethicone Crosspolymer, cyclomethicone, vitamin of above-mentioned weight percent E, the ginseng of C12-14 Pareth -7, the C13-14 isoparaffin of 1/4 weight percent and 1/4 weight percent extracts Object is mixed, and is uniformly dispersed, and B phase is made;
(2) successively by PEG-10 Polydimethylsiloxane cross-linked polymer, the polydimethylsiloxanes of above-mentioned weight percent Alkane, Cordyceps militaris extract, ascorbic acid, allantoin, PEG-100 stearate, epidermal growth factor, dipotassium glycyrrhizinate, acetyl group Hexapeptide -8, marine algae extract, Gotu Kola P.E, the C13-14 isoparaffin of 1/4 weight percent and 1/4 weight percent Ginseng root extract is added in oily phase pot, and stirring is warming up to 85 DEG C, is completely dissolved the substance in oily phase pot uniformly, A is made Phase;
(3) by acrylic acid (ester) class of above-mentioned weight percent/C10-30 alkylol acrylamide acid esters cross-linked polymer, fourth two The ginseng root extract of alcohol, the C13-14 isoparaffin of 1/4 weight percent and 1/4 weight percent mixes, and is uniformly dispersed C phase is made;
(4) successively by the water of above-mentioned weight percent, EDETATE SODIUM, glycerol, Sodium Hyaluronate, 1/4 weight percent The ginseng root extract of C13-14 isoparaffin and 1/4 weight percent is added in water phase pot, is stirring evenly and then adding into step (3) the C phase prepared, is warming up to 85 DEG C, is pumped into after being completely dissolved uniformly to emulsion pot, while stirring is warming up to 85 DEG C, and D is made Phase;
(5) B prepared by step (1) is added in A phase prepared by step (2) in oily phase pot, stirring is warming up to 85 DEG C, complete After fully dissolved is uniform, emulsion pot is evacuated to 0.015MPa, is slowly pumped into the material in oily phase pot through filter screen using negative pressure It is emulsified in emulsion pot, while low whipping speed is homogeneous 20min under conditions of 2800rpm/min, opens and follows after emulsification The cooling of ring water, and vacuum is kept to defoam, E phase is made;
(6) E phase prepared by step (5) is cooled to 60 DEG C, the Qarnet orchid for sequentially adding above-mentioned weight percent is extracted D prepared by object, strand radix angelicae sinensis leaf/stem extraction, laureth -7, potato pulp extract, Phenoxyethanol and step (4) Phase, under conditions of low whipping speed is 2800rpm/min after homogeneous 8min, vacuumizing and defoaming is prepared into semi-finished product;
(7) semi-finished product that step (6) is prepared are cooled to 38 DEG C, are obtained product anti-wrinkle cream after the assay was approved.
Embodiment 3
A kind of compact tender skin smoothing wrinkle eye cream of quantum, by forming following weight percentage components:
A kind of preparation method of the compact tender skin smoothing wrinkle eye cream of quantum, includes the following steps:
(1) by the Dimethicone Crosspolymer, cyclomethicone, vitamin of above-mentioned weight percent E, the ginseng of C12-14 Pareth -7, the C13-14 isoparaffin of 1/4 weight percent and 1/4 weight percent extracts Object is mixed, and is uniformly dispersed, and B phase is made;
(2) successively by PEG-10 Polydimethylsiloxane cross-linked polymer, the polydimethylsiloxanes of above-mentioned weight percent Alkane, Cordyceps militaris extract, ascorbic acid, allantoin, PEG-100 stearate, epidermal growth factor, dipotassium glycyrrhizinate, acetyl group Hexapeptide -8, marine algae extract, Gotu Kola P.E, the C13-14 isoparaffin of 1/4 weight percent and 1/4 weight percent Ginseng root extract is added in oily phase pot, and stirring is warming up to 83 DEG C, is completely dissolved the substance in oily phase pot uniformly, A is made Phase;
(3) by acrylic acid (ester) class of above-mentioned weight percent/C10-30 alkylol acrylamide acid esters cross-linked polymer, fourth two The ginseng root extract of alcohol, the C13-14 isoparaffin of 1/4 weight percent and 1/4 weight percent mixes, and is uniformly dispersed C phase is made;
(4) successively by the water of above-mentioned weight percent, EDETATE SODIUM, glycerol, Sodium Hyaluronate, 1/4 weight percent The ginseng root extract of C13-14 isoparaffin and 1/4 weight percent is added in water phase pot, is stirring evenly and then adding into step (3) the C phase prepared, is warming up to 83 DEG C, is pumped into after being completely dissolved uniformly to emulsion pot, while stirring is warming up to 83 DEG C, and D is made Phase;
(5) B prepared by step (1) is added in A phase prepared by step (2) in oily phase pot, stirring is warming up to 83 DEG C, complete After fully dissolved is uniform, emulsion pot is evacuated to 0.02MPa, and the material in oily phase pot is slowly pumped into cream through filter screen using negative pressure Change and emulsified in pot, while low whipping speed is homogeneous 18min under conditions of 3500rpm/min, open cycle after emulsification Water cooling, and vacuum is kept to defoam, E phase is made;
(6) E phase prepared by step (5) is cooled to 55 DEG C, the Qarnet orchid for sequentially adding above-mentioned weight percent is extracted D prepared by object, strand radix angelicae sinensis leaf/stem extraction, laureth -7, potato pulp extract, Phenoxyethanol and step (4) Phase, under conditions of low whipping speed is 3500rpm/min after homogeneous 5min, vacuumizing and defoaming is prepared into semi-finished product;
(7) semi-finished product that step (6) is prepared are cooled to 38 DEG C, are obtained product anti-wrinkle cream after the assay was approved.
Comparative example 1
A kind of tradition anti-wrinkle cream, by forming following weight percentage components:
A kind of preparation method of tradition anti-wrinkle cream, the specific steps are as follows:
(1) by the cyclomethicone of above-mentioned weight percent, PEG-10 Polydimethylsiloxane cross-linked polymer, The cetearyl alcohol of dimethyl silicone polymer, tocopherol acetate, the carbonic acid dioctyl ester of 1/3 weight percent, 1/3 weight percent The stearine of pure and mild 1/3 weight percent is mixed, and is uniformly dispersed and B phase is made;
(2) successively by the caprylic/capric triglyceride of above-mentioned weight percent, C12-15 alcohol benzoic ether, dormant oil, pupa worm Careless extract, allantoin, ascorbic acid (VC), PEG-100 stearate, EGF epidermal growth factor (20,000 unit), glycyrrhizic acid Dipotassium, the carbonic acid dioctyl ester of 1/3 weight percent, 1/3 weight percent pure and mild 1/3 weight percent of cetearyl alcohol glycerol Stearate is added in oily phase pot, and stirring is warming up to 80~85 DEG C, is completely dissolved the substance in its oily phase pot and A is uniformly made Phase;
(3) successively by the butanediol of above-mentioned weight percent, the carbonic acid dioctyl ester of 1/3 weight percent, 1/3 weight percent The stearine of pure and mild 1/3 weight percent of the cetearyl alcohol of ratio is added in water phase pot, and stirring and dissolving uniformly heats up afterwards It to 80~85 DEG C, is then pumped into emulsion pot, stirring is warming up to 80~85 DEG C and C phase is made;
(4) manufactured B is added in the A phase prepared in oily phase pot, stirring is warming up to 80~85 DEG C, is completely dissolved After even, emulsion pot is evacuated to 0.03MPa, is slowly pumped into the material in oily phase pot to emulsion pot through filter screen using negative pressure It is emulsified, while low whipping speed is homogeneous is carried out under conditions of 3000rpm/min, time control is in 15-20min, emulsification After open cycle water cool down, and keep vacuum to defoam, E phase be made;
(5) obtained E phase is cooled to 45 DEG C, the water, EDETATE SODIUM, glycerol, hyalomitome of above-mentioned weight percent is added The C phase that sour sodium and step (3) obtain, after stirring simultaneously homogeneous 3-5min, vacuumizing and defoaming is prepared into semi-finished product;
(6) obtained semi-finished product are continued to be cooled to 38 DEG C, obtains traditional anti-wrinkle cream after the assay was approved.
Test 1 skin irritation test
Skin irritation test is carried out to the anti-wrinkle cream that embodiment 1-3 is prepared
Using 60 women and 40 males as experimental subjects, 5 groups are randomly divided into, is prepared respectively using embodiment 1-3 Compact tender skin anti-wrinkle cream and the traditional anti-wrinkle cream that is prepared of comparative example 1 as sample carry out skin irritation test, be used in combination Water does blank control.It takes 0.03ml sample to be placed in the coyote hole of spot examination adhesive tape with syringe, the spot for being equipped with sample is tried into glue immediately Band is longitudinal since lower part to be pasted on the normal skin of left forearm, while light pressing room and makes to test one by one to drive away air Object is uniformly distributed.Experiment position marks, to observe.It is primary every 24 hours patch skins, it opens half an hour after patch, and It is checked according to the term of CTFA (1981) guide.6 patch tests are carried out altogether, paste the 6th day after skin, in order to Delayed response is observed, additional inspection has been carried out.Data are then compared using last inspection result.Qualification process is mark with table 1 It is quasi-;Table 2 is that substances are respectively the compact tender skin anti-wrinkle cream that embodiment 1-3 is prepared and the biography that comparative example 1 is prepared The irritation test result for anti-wrinkle cream of uniting.
Table 1
Grade Symbol Standard of perfection
0 Negative reaction: non-stimulated, without erythema
1 Soil Suspicious reaction: slight erythema
2 + Weakly positive reaction: erythema
3 ++ Strong positive reaction: erythema, papule, blister
4 +++ Extremely strong positive reaction: serious edema, bulla
Table 2
Lagging number Comparative example 1 Blank control Embodiment 1 Embodiment 2 Embodiment 3
1 0 0 0 0 0
2 0 0 0 0 0
3 1 soil 0 0 0 0
4 1 soil 0 0 0 0
5 1 soil 0 0 0 0
6 1 soil 0 0 0 0
After the 6th day 1 soil 0 0 0 0
It is total 5 soil 0 0 0 0
Table 2 the experimental results showed that, blank test is non-stimulated, the compact tender skin anti-wrinkle cream pair that embodiment 1-3 is prepared Skin is also non-stimulated, and traditional anti-wrinkle cream still has the stimulate the reaction of skin.Thus removed using compact tender skin of the invention After wrinkle frost, human body does not have any discomfort or allergic reaction, and anti-wrinkle cream of the invention has safety relative to general anti-wrinkle cream product Non-stimulated feature.
Test the test of 2 tightening effects
25-30 years old coarse women of 80 eye part skins is chosen, first, second, third, four groups of fourth, every group of 20 people are divided into. Wherein, first, second, the third three groups of compact tender skin anti-wrinkle creams being prepared respectively using embodiment 1-3;Fourth group uses traditional smoothing wrinkle Frost compares after 2 months respectively using once sooner or later daily:
1, comparing result:
First group: being improved significantly at once using the eye part skin of 20 people after product, and coarse texture is reduced or disappeared, Skin moment seems smooth, compact;
Second group: using improving significantly after the eye part skin 15-20min of 20 people after product, coarse texture is reduced Or disappear, skin seems smooth, compact;
Third group: using improving significantly after the eye part skin 12-18min of 20 people after product, coarse texture is reduced Or disappear, skin seems smooth, compact;
Fourth group: it is not improved substantially using the eye part skin of 20 people after product, skin is still coarse, only just applies Slightly water moisture feeling when upper product.
2, long-term comparing result:
First group: the eye part skin of 19 people has clear improvement, and coarse texture is reduced or disappeared, and skin is moist;
Second group: the eye part skin of 18 people has clear improvement, and coarse texture is reduced or disappeared, and skin is moist;
The eye part skin of third group: 18 people has clear improvement, and coarse texture is reduced or disappeared, and skin is moist;
Fourth group: the eye part skin of 6 people has clear improvement, and in addition has the eye part skin of 3 people slightly to improve, remaining people's Eye skin is still coarse.
By comparative test, the discovery present invention has remarkable effect to eye part skin, eye skin can be promoted to regenerate, reached Mitigate wrinkle, the effect of compact skin;There is moment to smooth eye part skin microgroove simultaneously, compact eye circumference skin keeps skin fine and smooth It is smooth, the effect of skin is not stimulated, is suitble to be used for a long time.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, as defined herein General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one The widest scope of cause.

Claims (3)

1. a kind of compact tender skin smoothing wrinkle eye cream of quantum, which is characterized in that by forming following weight percentage components:
2. the compact tender skin smoothing wrinkle eye cream of a kind of quantum according to claim 1, which is characterized in that by following weight percent Group be grouped as:
3. any a kind of preparation method of the compact tender skin smoothing wrinkle eye cream of quantum according to claim 1~2, which is characterized in that Include the following steps:
(1) by the Dimethicone Crosspolymer of above-mentioned weight percent, cyclomethicone, vitamin E, The ginseng root extract of C12-14 Pareth -7, the C13-14 isoparaffin of 1/4 weight percent and 1/4 weight percent It is mixed, and is uniformly dispersed, B phase is made;
(2) successively by PEG-10 Polydimethylsiloxane cross-linked polymer, dimethyl silicone polymer, the pupa of above-mentioned weight percent Cordyceps, ascorbic acid, allantoin, PEG-100 stearate, epidermal growth factor, dipotassium glycyrrhizinate, acetyl group hexapeptide- 8, the ginseng of marine algae extract, Gotu Kola P.E, the C13-14 isoparaffin of 1/4 weight percent and 1/4 weight percent Root extract is added in oily phase pot, and stirring is warming up to 80~85 DEG C, is completely dissolved the substance in oily phase pot uniformly, A is made Phase;
(3) by acrylic acid (ester) class of above-mentioned weight percent/C10-30 alkylol acrylamide acid esters cross-linked polymer, butanediol, 1/4 The ginseng root extract mixing of the C13-14 isoparaffin and 1/4 weight percent of weight percent, and be uniformly dispersed and C is made Phase;
(4) successively by the water of above-mentioned weight percent, EDETATE SODIUM, glycerol, Sodium Hyaluronate, 1/4 weight percent C13- The ginseng root extract of 14 isoparaffins and 1/4 weight percent is added in water phase pot, is stirring evenly and then adding into step (3) system Standby C phase, is warming up to 80~85 DEG C, is pumped into after being completely dissolved uniformly to emulsion pot, while stirring is warming up to 80~85 DEG C, system At D phase;
(5) B prepared by step (1) is added in A phase prepared by step (2) in oily phase pot, stirring is warming up to 80~85 DEG C, complete After fully dissolved is uniform, emulsion pot is evacuated to 0.015-0.03MPa, using negative pressure that the material in oily phase pot is slow through filter screen It is pumped into emulsion pot and is emulsified, while low whipping speed is homogeneous 15-20min under conditions of 2800-3500rpm/min, cream Open cycle water cools down after change, and keeps vacuum to defoam, and E phase is made;
(6) E phase prepared by step (5) is cooled to 45~60 DEG C, the Qarnet orchid for sequentially adding above-mentioned weight percent is extracted D prepared by object, strand radix angelicae sinensis leaf/stem extraction, laureth -7, potato pulp extract, Phenoxyethanol and step (4) Phase, under conditions of low whipping speed is 2800-3500rpm/min after homogeneous 3-8min, vacuumizing and defoaming is prepared into semi-finished product;
(7) semi-finished product that step (6) is prepared are cooled to 38 DEG C, are obtained product anti-wrinkle cream after the assay was approved.
CN201811384934.4A 2018-11-20 2018-11-20 A kind of compact tender skin smoothing wrinkle eye cream of quantum and preparation method thereof Pending CN109512737A (en)

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Application Number Priority Date Filing Date Title
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111821244A (en) * 2019-04-18 2020-10-27 康红涛 Firming and brightening eye cream
CN114344220A (en) * 2022-01-27 2022-04-15 广州普伽娜生物科技有限公司 Whitening essence and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
国家药品监督管理局: "《化妆品监督管理常见问题解答(一)》", 10 January 2019 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111821244A (en) * 2019-04-18 2020-10-27 康红涛 Firming and brightening eye cream
CN114344220A (en) * 2022-01-27 2022-04-15 广州普伽娜生物科技有限公司 Whitening essence and preparation method thereof

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Application publication date: 20190326