CN109512545A - The big animal organism aerosol mouth and nose exposure system of biological safe type primate - Google Patents
The big animal organism aerosol mouth and nose exposure system of biological safe type primate Download PDFInfo
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- CN109512545A CN109512545A CN201710845874.0A CN201710845874A CN109512545A CN 109512545 A CN109512545 A CN 109512545A CN 201710845874 A CN201710845874 A CN 201710845874A CN 109512545 A CN109512545 A CN 109512545A
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- 239000000443 aerosol Substances 0.000 title claims abstract description 88
- 241001465754 Metazoa Species 0.000 title claims abstract description 67
- 241000288906 Primates Species 0.000 title claims abstract description 40
- 238000012545 processing Methods 0.000 claims abstract description 15
- 238000001514 detection method Methods 0.000 claims abstract description 8
- 238000011084 recovery Methods 0.000 claims abstract description 8
- 239000002912 waste gas Substances 0.000 claims abstract description 8
- 210000001364 upper extremity Anatomy 0.000 claims description 19
- 238000004140 cleaning Methods 0.000 claims description 17
- 210000003141 lower extremity Anatomy 0.000 claims description 16
- 230000029058 respiratory gaseous exchange Effects 0.000 claims description 13
- 210000001217 buttock Anatomy 0.000 claims description 11
- 238000007789 sealing Methods 0.000 claims description 7
- 230000000241 respiratory effect Effects 0.000 claims description 2
- 238000002474 experimental method Methods 0.000 abstract description 19
- 231100000614 poison Toxicity 0.000 abstract description 3
- 230000007096 poisonous effect Effects 0.000 abstract description 2
- 239000007789 gas Substances 0.000 description 22
- 230000002093 peripheral effect Effects 0.000 description 12
- 238000012360 testing method Methods 0.000 description 11
- 241000282693 Cercopithecidae Species 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 5
- 231100000027 toxicology Toxicity 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 230000002110 toxicologic effect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000010171 animal model Methods 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 239000002360 explosive Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000000505 pernicious effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241000283216 Phocidae Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 231100000727 exposure assessment Toxicity 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
- A61D2003/003—Appliances for supporting or fettering animals for operative purposes with head or neck restraining means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
- A61D2003/006—Appliances for supporting or fettering animals for operative purposes with leg or foot restraining means
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Husbandry (AREA)
- Housing For Livestock And Birds (AREA)
- Ventilation (AREA)
Abstract
The invention discloses a kind of big animal organism aerosol mouth and nose exposure systems of biological safe type primate, solves the poisonous and harmful aerosol mouth and nose sucking exposure experiment problem that the big animal of primate how is effectively carried out in safely controllable environment, its technical solution be include aerosol generating device, mouth and nose exposure unit, automatic control device, detection device and waste gas recovery processing unit, it further include Biohazard Safety Equipment, the Biohazard Safety Equipment is provided with exposed chamber and the chamber wall for closing exposed chamber, the exposed chamber is disposed for placing aerosol generating device and/or mouth and nose exposure unit, the interface for being connected with vacuum tiny structure processing unit is provided on the chamber wall.The design of the technical essential, having reached prevents situations such as aerosol is leaked to the pollution caused in atmosphere to experimenter and environment in experimentation generation, securely and reliably.
Description
Technical field
The present invention relates to animals to suck toxicological experiment field, raw more particularly to a kind of big animal of biological safe type primate
Object aerosol mouth and nose exposure system.
Background technique
In general, sucking toxicological experiment is the approach for simulating worker and resident's contact noxious material, to production operation ring
Industrial chemistry substance in border, the poisonous substance in the atmosphere of resident living area based on environmental contaminants carry out quiet formula or dynamic inhalation contamination,
Obtain the data of inhalation toxicology, including toxicity on inhalation (such as half lethal concentration, harmless activity) mechanism of action and examination
Test treatment as a result, be formulate in workshop air and in the atmosphere of residential block harmful substance important evidence.Currently, being to suck poison
It manages in relevant various scientific researches, more especially pair human health nuisance Quality Research, such as PM2.5, due to cannot
Directly or the mankind cannot be tested first, so often to use experimental animal to carry out sucking Exposure Assessment.Therefore, animal
Exposing device has a wide range of applications in industry, agricultural, medicine, environmental pollution and military science research.However, existing sudden and violent
Dew experiment in some exposure tests, since mouse etc. and people's difference are too big, cannot effectively be reacted primarily directed to mouse etc.
Influence of the harmful substance to people, therefore, some scientific research personnel are proposed using the big animal such as primate such as monkey as exposure
Object is tested with making full use of primate with characteristic similar in people.And it is sudden and violent in existing some big animal mouth and nose
In dew system, due to not having biological safety protection device, system is easy to happen the leakage of the pernicious gases such as aerosol, causes to ring
Border and the pollution of experimenter etc., therefore, how to make primate can be carried out effectively mouth and nose exposure test with
And the security performance of big animal mouth and nose exposure system is improved, avoid the leakage of its pernicious gas such as aerosol during the experiment from being
This field urgent problem to be solved.
Summary of the invention
In view of the deficiencies of the prior art, the present invention intends to provide a kind of big animal of biological safe type primate
Bioaerosol mouth and nose exposure system.
To achieve the above object, the present invention provides the following technical scheme that a kind of big animal of biological safe type primate is raw
Object aerosol mouth and nose exposure system, including aerosol generating device, mouth and nose exposure unit, automatic control device, detection device and
Waste gas recovery processing unit further includes Biohazard Safety Equipment, and the Biohazard Safety Equipment has exposure chamber and for closing exposed chamber
Chamber wall, the exposed chamber is disposed for placing aerosol generating device and/or mouth and nose exposure unit, on the chamber wall
It is provided with the interface for being connected with vacuum tiny structure processing unit.
By using above-mentioned technical proposal, in carrying out animal mouth and nose exposure experimentation, Biohazard Safety Equipment can will be let out
The substances such as the aerosol of leakage are accommodated in exposed chamber, and the aerosol of leakage is avoided to be directly entered in atmosphere to experimenter and environment
Bring pollution；
Vacuum tiny structure processing unit is connected on chamber wall, can be further improved the intracavitary experiment safety performance of exposure, exposure
Intracavitary gas will not be leaked in atmosphere.
The present invention is further arranged to: the chamber wall includes operation panel, is provided with handle hole on the operation panel,
Operating gloves are sealedly connected at the handle hole, the operating gloves are configured for experimenter's wearing, so that the experiment
The hand of personnel can extend into the exposed chamber and carry out experimental implementation.
By using above-mentioned technical proposal, under the premise of guaranteeing that exposure chamber is closed, experimenter can be intracavitary to exposure
Aerosol generating device or mouth and nose exposure unit carry out operation adjustment, the airtight performance for further ensuring exposed chamber is good,
Avoid that outside air enters exposed chamber or the aerosol of the intracavitary leakage of exposure enters in atmosphere, structure is simple, safety
It is high.
The present invention is further arranged to: the Biohazard Safety Equipment further includes transferring cabin, and it is real that the transferring cabin is configured to transmitting
Object used in the process of testing；And the transferring cabin is communicated with air cleaning device, the air cleaning device is configured to transmitting
Aerosol generating device or mouth and nose exposure unit in cabin carry out pure air cleaning.
By using above-mentioned technical proposal, when transmitting the object needed in experimentation, do not need to open exposed chamber progress
Transmitting, directly by transferring cabin be transmitted to expose it is intracavitary, avoid aerosol generating device and mouth and nose exposure unit directly with sky
Gas contact；Meanwhile the transferring cabin is communicated with air cleaning device, the air cleaning device is configured to in transferring cabin
Test with object carry out pure air clean.
The present invention is further arranged to: the transferring cabin includes entrance hatch, is connected at the entrance hatch into hatch door；
The transferring cabin and exposure chamber junction are the egress hatch of transferring cabin, are connected with out hatch door at the egress hatch.
By using above-mentioned technical proposal, in the object transmit process needed for experimentation, hatch door can be with into hatch door and out
The object is enclosed in transferring cabin, air cleaning device can clean it, guarantee to enter the intracavitary test of exposure
It is sterile with object.
The present invention is further arranged to: the Biohazard Safety Equipment be it is multiple, including the first Biohazard Safety Equipment and second biology
Safety cabinet, the exposure chamber of first Biohazard Safety Equipment are configured to place aerosol generating device, second Biohazard Safety Equipment
Exposure chamber be configured to place mouth and nose exposure unit.
By using above-mentioned technical proposal, aerosol generating device and mouth and nose exposure unit are individually placed to different biology peaces
In full cabinet, when aerosol generating device is dismounted or safeguarded, mouth and nose exposure unit not will receive impurity in outside air
Pollution, conversely, aerosol generating device will not be contaminated when mouth and nose exposure unit is dismounted or safeguarded, the two phase
It is mutually independent, it maintains easily.
The present invention is further arranged to: first Biohazard Safety Equipment is set as one, and second Biohazard Safety Equipment is set
It is set to multiple, and the mouth and nose exposure unit in multiple second Biohazard Safety Equipments is molten with the gas of first Biohazard Safety Equipment
The connection of glue generating device.
By using above-mentioned technical proposal, an aerosol generating device can connect multiple mouth and nose exposures in experimentation
Unit can carry out the mouth and nose exposure experiment of same concentration to multiple animals, and structure is simple, easy to operate.
The present invention is further arranged to: the intracavitary aerosol generating device of the first Biohazard Safety Equipment exposure and multiple institutes
It states the intracavitary mouth and nose exposure unit of the second Biohazard Safety Equipment exposure to connect by snorkel, and the snorkel is identical.
By using above-mentioned technical proposal, it is ensured that aerosol generating device is conveyed to the gas of multiple mouth and nose exposure units
Collosol concentration is uniform, improves experiment accuracy.
The present invention is further arranged to: the mouth and nose exposure unit includes animal seat, and the animal is removable with seat
Unload be mounted on the second Biohazard Safety Equipment exposure it is intracavitary；
Animal seat includes vehicle frame, the vehicle frame, head fixing device, upper limb fixing device, buttocks seat plate and lower limb
Fixed device, and the head fixing device, the upper limb fixing device, the buttocks seat plate and the lower limb fixing device are equal
Position is adjustably mounted in the vehicle frame in the vertical direction.
By using above-mentioned technical proposal, it can be used for fixed primate such as monkey etc. to carry out mouth and nose sucking exposure
Experiment can guarantee that the primates such as monkey have phase to obtain better experiment effect and closer experimental data
The comfort level etc. answered, structure is simple, easy to operate.
The present invention is further arranged to: the mouth and nose exposure unit includes animal mouth and nose exposure component, and the mouth and nose are sudden and violent
Revealing component includes shield, breathing mask, suction line and discharge line；
The shield includes housing and sealing structure, and the housing has head insert port, so that the head of animal is via institute
Head insert port is stated to protrude into the shield；The sealing structure is installed on the head insert port, to seal the neck of animal
Region between portion and the head insert port；
The breathing mask is set in the shield, is configured to be installed on the face of animal；
The suction line and the discharge line are connected to the breathing mask, and negative pressure mouth is provided on the housing,
The negative pressure mouth is configured to connecting power device, so as to keep negative pressure state in the shield.
By using above-mentioned technical proposal, it is real can to carry out mouth and nose exposure to primate for the setting of mouth and nose exposure component
It tests, tests substance, the settings of shield such as the effective Inhaled Aerosol of primate is enable to can effectively prevent gas
The leakage of the substances such as colloidal sol, the further safety for guaranteeing experimenter and equipment.
The present invention is further arranged to: mouth and nose exposure component in backwards to upper limb fixing device side removably
It is installed on the head fixing device.
By using above-mentioned technical proposal, first mouth and nose exposure component can be fixedly mounted on head fixing device, then
The exposure that mouth and nose exposure component and animal seat are installed along with Biohazard Safety Equipment is intracavitary, and structure is simple, easy to operate；Setting
It is kept away at the mounting means being detachably connected for the ease of mouth and nose exposure component and animal seat are safeguarded and adjusted respectively
Both exempt from integrated setting both cause to influence each other, the influence for safeguard inconvenience etc..
According to the following detailed description of specific embodiments of the present invention in conjunction with the accompanying drawings, those skilled in the art will be brighter
The above-mentioned and other purposes, advantages and features of the use of the new type.
Detailed description of the invention
Hereinafter with reference to the accompanying drawings and embodiment some specific implementations of mode detailed description of the present invention and not restrictive
Example.Identical appended drawing reference denotes same or similar part or part in attached drawing.It should be appreciated by those skilled in the art that this
A little attached drawings are not necessarily to scale drafting.Meanwhile some pipelines in figure do not represent all, those skilled in the art should
Understand embodiments thereof.In attached drawing:
Fig. 1 is that the overall structure of the big animal organism aerosol mouth and nose exposure system embodiment of biological safe type primate of the present invention is shown
It is intended to；
Fig. 2 is the structure of Biohazard Safety Equipment in the big animal organism aerosol mouth and nose exposure system of biological safe type primate of the present invention
Schematic diagram；
Fig. 3 is the explosion of animal seat in the big animal organism aerosol mouth and nose exposure system of biological safe type primate of the present invention
Property schematic diagram；
Fig. 4 is the quick-fried of mouth and nose exposure component in the big animal organism aerosol mouth and nose exposure system of biological safe type primate of the present invention
Fried property schematic diagram.
In attached drawing: 1. air compressor machines；2. vacuum pump；3. aerosol generating device；4. mouth and nose exposure unit；41. mouth and nose exposure
Component；411. shield；The head 411a. insert port；412. breathing mask；413. negative pressure mouths；414；Discharge pipe crossing；415；It inhales
Enter line portals；416. cover；417. flexible sheets；End is inserted on 418. heads；419. fixed ring；42. animal seat；421. chair
Frame；421a. frame cavity；421b. guide channel；421c. adjusts guide groove；422. upper limb fixing device；422a. first is fixed
Half-turn；422b. second fixes half-turn；423. buttocks seat plates；424. lower limb fixing device；424a. third fixes half-turn；424b.
4th fixed half-turn；425. chassis base；426. head fixing device；4261. movable plate；4262. support column；4263. guide rail
Item；427. are screwed handle；5. Biohazard Safety Equipment；51. the first Biohazard Safety Equipment；52. the second Biohazard Safety Equipment；511. exposure
Chamber；512. chamber wall；512a. interface；513. transferring cabin；514. operation panel；514a. handle hole.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below with reference to Fig. 1 to Fig. 4 to this
The embodiment of the big animal organism aerosol mouth and nose exposure system of invention biological safe type primate is described further.
Fig. 1 is that the overall structure of the big animal organism aerosol mouth and nose exposure system of biological safe type primate of the present invention is illustrated
Figure.As shown in Figure 1, a kind of big animal organism aerosol mouth and nose exposure system of biological safe type primate, including pump head air compressor machine
1, blower 2, aerosol generating device 3, mouth and nose exposure unit 4, automatic control device, detection device and waste gas recovery processing dress
It sets.The big animal organism aerosol mouth and nose exposure system of biological safe type primate further includes Biohazard Safety Equipment 5, and aerosol fills
Set 3 and mouth and nose exposure unit 4 be arranged in the Biohazard Safety Equipment 5, specific embodiment is as follows:
As shown in Fig. 2, Biohazard Safety Equipment 5 includes support portion and work department, support portion and work department are hollow setting, support portion
It can be simply provided to be used to support work department, may be set to be including object placing cavity, work department is provided with exposed chamber 511, cruelly
Revealing chamber 511 includes top plate and bottom plate and surrounding chamber wall 512, and surrounding chamber wall 512 includes fixed panel and operation panel 514, behaviour
Make panel 514 with the side of fixed panel and top plate using fixation is threadedly coupled, is provided with handle hole on operation panel 514
It is sealedly connected at 514a, handle hole 514a operating gloves (not represented in figure), specific connection type is at handle hole 514a
It is connected with connection ring (not representing in figure), connection ring is set as step-like, including mounting portion and sticking part, the diameter of mounting portion
Less than sticking part diameter and mounting portion and operation panel are located at sticking part two sides, and sticking part and 514 screw of operation panel are solid
It is fixed to connect, it is provided with groove on mounting portion, fastening elastic ring is provided in groove, operating gloves first cover on mounting portion, then
Elastic snare will be fastened in operating gloves and place fastening elastic ring matching in the trench, complete the installation to operating gloves
It is fixed.Preferably, the operation panel 514 is set as being oppositely arranged before and after two and two operation panels 514.
In further embodiment of the invention, Biohazard Safety Equipment 5 further includes transferring cabin 513, and the transferring cabin 513 is set
It sets on chamber wall 512, the present invention is preferably the setting of transferring cabin 513 on fixed panel.Transferring cabin 513 includes entrance hatch and goes out
Hatch (being to represent in figure) is provided at entrance hatch and egress hatch for into hatch door and going out transferring cabin 513 is closed
Hatch door, entrance hatch are in the outside of Biohazard Safety Equipment 5, egress hatch be located at the inside of Biohazard Safety Equipment 5 and with exposure 511 phase of chamber
It is logical.For the ease of the closure of hatch door, it is provided with sliding slot on fixed panel, hatch door includes the sliding part to match with sliding slot out, out
The folding that hatch door is slided on fixed panel to realize egress hatch.Transferring cabin 513 is connected with air cleaning device and (does not indicate in figure
Out), air cleaning device includes blower, gas supply pipeline and exhaust pipe, and specific embodiment is, and up and down the two of transferring cabin 513
Side is provided with pipe interface, and downside pipe interface is connected with gas supply pipeline, and gas supply pipeline is connected with blower, is used for transferring cabin
Air are conveyed in 513, gas supply pipeline is also connected with air filter, for enter the cleaning air of transferring cabin 513 into
Row filtering, guarantees the degree of purity of cleaning air, more thorough to the object cleaning being located in transferring cabin 513；Upside pipe interface
Exhaust pipe is connected, for used air extraction transferring cabin 513 will to be cleaned.
The course of work, if desired to exposure chamber 511 in transmit experiment object when, can first close out hatch door, open into
Required object is transported in transferring cabin 513 by hatch door, is then shut off into hatch door, is opened air cleaning device, at this time air-blower control
It supplies gas into transferring cabin 513, air filter enters in transferring cabin 513 after first carrying out filtration, purification to gas to required object
It is cleaned, is then extracted out by exhaust pipe, at this point, operator, which puts on operating gloves, extend into exposure in handle hole 514a
Hatch door will be gone out in chamber 511 to open, and the experiment is moved to the appropriate location in exposed chamber 511 with object, be then shut off out cabin
Door.During whole operation, the exposure discord contacting external air of chamber 511 ensure that sterile free from admixture in exposed chamber 511, whole
Operating gloves are put in operation, and hand is not direct with experiment isoelectric membrane, and the accuracy of experiment can be improved.Before operation panel 514
After be oppositely arranged by two and be made of transparent material, convenient for in exposure chamber 511 aerosol generating device 3 or mouth and nose it is sudden and violent
Dew unit 4 is moved or is safeguarded.
In further embodiment of the present invention, multiple interface 512a are provided on the chamber wall 512 of Biohazard Safety Equipment 5,
In an interface 512a be connected with vacuum tiny structure processing unit, an interface 512a connection waste gas recovery processing unit, remaining
Interface for being connected to aerosol generating device 3 and mouth and nose exposure unit 4, vacuum tiny structure device include check valve, differential pressure indicator and
Vacuum pump, the aerosol in exposure chamber 5a for guaranteeing Biohazard Safety Equipment 5 will not leak into atmosphere.Waste gas recovery processing dress
It sets and is connected with power device, during the aerosol and zoopery for having leakage in exposure chamber 511 when the exhaust gas of generation, give up
Gas recovering device can draw it out exposed chamber 511.
By setting Biohazard Safety Equipment 5, waste gas recovery processing component and vacuum tiny structure processing unit, aerosol can be prevented
Leakage, eliminates the pollution to operator, improves the precision of safety and contamination.
In further embodiment of the present invention, Biohazard Safety Equipment 5 is set as multiple, is divided into first Biohazard Safety Equipment
51 and multiple second Biohazard Safety Equipments 52, aerosol generating device 3 be removably fixedly mounted in the first Biohazard Safety Equipment 51,
In the exposure chamber 5a in the first Biohazard Safety Equipment 51, mouth and nose exposure unit 4, which is detachably fixed, is mounted on second biology
In the exposure chamber 5a of safety cabinet 52, aerosol generating device 4 and mouth and nose exposure unit 5 are connected by pipeline (not representing in figure)
It is logical, and the interface 512a on pipeline and chamber wall 512 is tightly connected.
Preferably, the second Biohazard Safety Equipment 52 is set as 5, is fixedly installed with one in each second Biohazard Safety Equipment 52
Group mouth and nose exposure unit 4, and the mouth and nose exposure unit 52 in each second Biohazard Safety Equipment 52 is pacified with same first biology
Aerosol generating device 3 in full cabinet 51 connects, and the aerosol that aerosol generating device 3 generates enters the confession of five road pipelines simultaneously
The experimental animal of five groups of mouth and nose exposure units 4 is tested, and can observe different animals simultaneously under the aerosol of same concentrations
Toxicological experiment differential responses etc..
Preferably, five the second Biohazard Safety Equipments 52 are communicated with the connecting pipe length between the first Biohazard Safety Equipment 51, institute
It is consistent with connecting tube, so that the aerosol that same aerosol generating device 3 occurs is by identical pipeline in same work
Make to be divided into five groups in environment, guarantees the even concentration of five groups of aerosols, improve the accuracy of experiment.
In further embodiment of the present invention, mouth and nose exposure unit 4 includes animal seat 42 and mouth and nose exposure component 41.Figure
The schematic explosive view of animal seat shown in 3.The animal may include that chair frame 421, buttocks seat board 423, lower limb are fixed with seat
Device 424 and head fixing device 426 and upper limb fixing device 422.There is frame cavity 421a in chair frame 421.Buttocks seat
Plate 423 may be disposed in frame cavity 421a, and position is adjustably mounted in chair frame 421 in the vertical direction.Lower limb are fixed
Device 424 is set in frame cavity 421a, and position is adjustably mounted in chair frame 421 in the vertical direction.Head is fixed
Device 426 is set to the upside of chair frame 421, and upper limb fixing device 422 is set to the downside of head fixing device 426, and head is solid
Determine device 426 and upper limb fixing device 422 position be adjustable in the vertical direction to be installed on chair frame 421,.The animal seat
Chair when in use, can first adjust the height of buttocks seat board 423, be sitting in animal on buttocks seat board 423, then adjust lower limb
The height of fixed device 424, and the lower limb of animal are fixed, adjust head fixing device 426 and upper limb fixing device 422
Height, and head and upper limb are fixed.Structure is simple, easy to use, and animal can be made to have very high comfort level.
In some embodiments of the invention, the two sides of chair frame 421 all have multiple adjustment extended along the vertical direction and lead
To slot 421c；The both ends of buttocks seat board 423 and lower limb fixing device 424 are threadably secured handle 427 and are installed on difference
Adjustment guide groove 421c.In some embodiments, animal seat further includes support column 4262 and the first positioning column.Support column
4262 extend along the vertical direction, are provided with multiple horizontally extending first positioning holes on support column 4262, and multiple first
Location hole is spaced setting along the vertical direction.Head fixing device 426 is arranged in towards the one of buttocks seat plate 423 in support column 4262
Side.The rear side of chair frame 421 is provided with the guide channel 421b extended along the vertical direction.Support column 4262 is installed on guide channel
421b, and the first positioning column is installed on chair frame 421, and is inserted into a first positioning hole, so that support column 4262 is installed on chair frame
421。
In some embodiments of the invention, head fixing device 426 may include fixed plate, movable plate 4261, frame and
Two guide rail bars 4263.Frame is set to the upper end of support column 4262.Fixed plate is installed on frame, and has opening is advanced to lack
Mouthful.Movable plate 4261 has the notch of opening backwards, and is slidably mounted on fixed plate along the longitudinal direction.For example, fixed plate
Downside be provided with opposite two sliding slots of being open, the two sides of movable plate 4261 are respectively arranged at two sliding slots.Each guide rail bar
4263 are installed on frame, and each sliding slot can be formed between the fixed plate of 4263 upside of a guide rail bar 4263 and guide rail bar.It is excellent
Selection of land is provided with two rows of second location holes arranged along the longitudinal direction for the ease of the fixation on head on movable plate 4261.It is fixed
There are two third location holes for setting on plate；Animal seat further includes two the second positioning columns, and each second positioning column is successively inserted
Enter a third location hole and a second location hole, can conveniently and efficiently adjust the size of animal neck.
In some embodiments of the invention, for the ease of the fixation of lower limb, lower limb fixing device 424 includes two lower limb
Fixed part, each lower limb fixed part have the fixed half-turn 424b of the fixed half-turn 424a and the 4th of third.Third fixes half-turn 424a
Position is adjustably mounted in chair frame 421 in the vertical direction.One end of 4th fixed half-turn 424b is rotatably installed on the
Three fixed half-turn 424a, the other end are adjustably installed on the fixed half-turn 424a of third relative to the fixed position half-turn 424a of third,
To limit the lower limb fixation hole of adjusting jointly with the fixed half-turn 424a of third, the axis of lower limb fixation hole is along vertical side
To extension.
Similar with above-described embodiment, for the ease of the fixation of upper limb, upper limb fixing device 422 includes that two upper limbs are fixed
Portion；Each upper limb fixed part has the first fixed fixed half-turn 422b of half-turn 422a and second.First fixed half-turn 422a is fixed
In or be rotatably installed on head fixing device 426.Preferably first fixed half-turn 422a is rotatable around a vertical axis
Setting, in order to the activity of upper limb.One end of second fixed half-turn 422b is rotatably installed on the first fixed half-turn 422a, separately
One end is adjustably installed on the first fixed half-turn 422a relative to the first fixed position half-turn 422a, to fix half-turn with first
422a limits the upper limb fixation hole of adjusting jointly, and the axis of upper limb fixation hole is horizontally extending.
In further embodiment of the present invention, mouth and nose as shown in Figure 4 expose the explosive schematic diagram of component, and mouth and nose are sudden and violent
Revealing component 41 may include shield 411, breathing mask 412, suction line crossing 415 and discharge pipe crossing 414.Shield 411 can
Including housing and sealing structure.Housing has head insert port 411a, so that the head of animal is stretched via head insert port 411a
Enter in shield 411；Sealing structure is installed on head insert port 411a, with seal animal neck and head insert port 411a it
Between region.Shield 411 is set to the upside of head fixing device 416；For example, the upside of fixed plate can be placed in.Breathing
Mask 412 is set in shield 411, is configured to be installed on the face of primate.Breathing mask 412 is preferably long with spirit
The face of class animal such as monkey is adapted.Suction line crossing 415 and discharge pipe crossing 414 are connected to breathing mask 412, will
The aerosol that aerosol generating device generates is entered by suction line crossing 415 in the mouth and nose of primate, and discharge pipe is passed through
The gas etc. that crossing 414 breathes out primate is discharged to outside shield 411.Negative pressure mouth 413, negative pressure are additionally provided on housing
Mouthfuls 413 are configured to connecting power device, so as to keep negative pressure state in shield 411, can prevent in this way leakage aerosol or
Other gases are spread in air, are threatened to experimenter or equipment.Power device can be vacuum pump.Mouth and nose expose group
Part 41 can enable the tests substances such as primate effectively Inhaled Aerosol；Aerosol etc. can be effectively prevented in shield
The safety of leakage, guarantee test personnel and equipment etc..
In some embodiments of the invention, housing may include tubular peripheral wall portion, head insertion end 418 and cover 416.
The axis of tubular peripheral wall portion is arranged along the vertical direction.Head insertion end 418 may be disposed at the lower end of tubular peripheral wall portion, and wherein
Portion is provided with head insert port 411a.Cover 416 may be disposed at the upper end of tubular peripheral wall portion.Suction line crossing 415, discharge line
Mouth 414 and negative pressure mouth 413 are mountable to tubular peripheral wall portion.Preferably, housing, and respiratory surface are fixed in suction line crossing 415
Cover 412 is set to the inner end at suction line crossing 415.It the outer end at suction line crossing 415 can be with the efferent duct of aerosol generating device
Connection.Discharge pipe crossing 414 is connect with the pipe fitting for being installed on tubular peripheral wall portion, and connection pipe fitting and breathing mask 412
Hose or stereoplasm tube (not shown).Settable negative pressure pipe fitting in negative pressure mouth 413.
In some embodiments of the invention, cover 416 is removably installed in the upper end of tubular peripheral wall portion.Specifically,
The upper surface of cover 416 is provided with annular groove.Shield 411 further includes multiple rapid latchs, along the circumferential direction side of tubular peripheral wall portion
To the upper end for being distributed in tubular peripheral wall portion；And each rapid latch includes rotational handle and buckle；Rotational handle is rotationally pacified
Loaded on tubular peripheral wall portion；Buckle is rotatably installed on rotational handle, and matches with annular groove.
In some embodiments of the invention, sealing structure is the flexible sheets 417 with central opening；Flexible sheets 417 are pacified
End 418 is inserted into loaded on head.Head insert port 411a is stepped hole, and flexible sheets 417 are installed on stepped hole.Shield 411 is also
Including fixed ring 419, stepped hole is fixed on by screw, and with the step surface of stepped hole that flexible sheets 417 are sandwiched therebetween.
Preferably, flexible sheets 417 are silica gel piece.Tubular peripheral wall portion and head insertion end 418 are made of clear material, in order to more preferable
It is observed on ground.
Mouth and nose exposure component 41 when in use, can be then sharp by 411 sets of shield on the head of the primates such as monkey
With breathing mask 412, shield 411 tubular peripheral wall portion and and/or the auxiliary cushions such as sponge shield is fixed on head
In 411.Then the cover 416 of shield 411 is covered.
The present invention is mainly suitable for the toxicological experiment of primate, can first by aerosol generating device 3, detection device and
Automatic control device is fixed in the exposure chamber 511 of the first Biohazard Safety Equipment 51, and aerosol generating device 3 includes aerosol
Device, plunger pump, filter, diluter, detection device include mass concentration detector, and automatic control device includes that mass concentration passes
Sensor, pressure sensor.Aerosol generator generates aerosol, is transmitted at detection device by filter filtering, quality is dense
Spend detector and Concentration Testing carried out to the aerosol of transmission, when concentration deviation is larger, adjustable diluter to aerosol into
Row dilution or aerosol generator generate aerosol, and plunger pump is used to carry out fluid infusion to aerosol generator.Detection device and
Automatic control device can be set in the outside of the first Biohazard Safety Equipment 51, also can be arranged directly on the first Biohazard Safety Equipment 51
Exposure chamber 511 in.
When the big animal organism aerosol mouth and nose exposure system work of biological safe type primate of the present invention, first on the outside will
Primate such as monkey are fixed on animal on seat 42, its head is then entered mouth and nose by head insert port 411a
In the shield 411 of exposure component 41, breathing mask 412 is put on for monkey, is then fixedly mounted on mouth and nose exposure component 41
On the head fixing device 426 of animal seat 42, mounting means be preferably screwed handle connection；When to wear mouth and nose sudden and violent for monkey
Dew component 41 is simultaneously fixed on animal with after on seat 42, and then opening operation panel 514, mouth and nose exposure unit 4 is fixed on cruelly
Reveal in chamber 511, then closed procedure panel 514, first to pure air cleaning is carried out in exposure chamber 511, then opens air compressor machine
1, vacuum pump 2 is started to work, and pump head air compressor machine 1 drives the work of aerosol generating device 3 to generate aerosol and is delivered to mouth at this time
Nose exposure unit 5, in the whole process, the waste gas recovery processing unit on Biohazard Safety Equipment 5 can be to the gas in exposure chamber 511
Colloidal sol and exhaust gas extraction, the aerosol that negative pressure of vacuum processing unit can guarantee to expose in chamber 511, which will not leak into atmosphere, to be made
At pollution.When need to exposure chamber 511 in transmit experiment object when, open transferring cabin 513 into hatch door, which is sent to
In transferring cabin 513, open air cleaning device, fan aspirate, pneumatic filter to gas filtration then via gas supply pipeline into
Enter and the object is cleaned into transferring cabin 513, then gas is extracted via exhaust pipe, is then shut off into hatch door, behaviour
Operating gloves are put on as personnel extend into and object is moved to suitable position in exposed chamber 511 and operates star, be then shut off
Hatch door out.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, without departing from the principle of the present invention, made any improvements and modifications also should be regarded as protection of the invention
Range.
Claims (10)
1. a kind of big animal organism aerosol mouth and nose exposure system of biological safe type primate, including aerosol generating device, mouth
Nose exposure unit, automatic control device, detection device and waste gas recovery processing unit, it is characterised in that: further include bio-safety
There is exposure chamber and the chamber wall for closing exposed chamber, the exposed chamber to be disposed for putting for cabinet, the Biohazard Safety Equipment
Aerosol generating device and/or mouth and nose exposure unit are set, is provided on the chamber wall for being connected with the processing of vacuum tiny structure
The interface of device.
2. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 1, feature
Be: the chamber wall includes operation panel, and handle hole is provided on the operation panel, is tightly connected at the handle hole
Have an operating gloves, the operating gloves are configured for experimenter's wearing so that the hand of the experimenter can extend into it is described
Experimental implementation is carried out in exposure chamber.
3. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 1, feature
Be: the Biohazard Safety Equipment further includes transferring cabin, and the transferring cabin is configured to object used in transmitting experimentation；
The transferring cabin is communicated with air cleaning device, and the air cleaning device is configured to that the aerosol in transferring cabin occurs
Device or mouth and nose exposure unit carry out pure air cleaning.
4. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 3, feature
Be: the transferring cabin includes entrance hatch, is connected at the entrance hatch into hatch door；
The transferring cabin and exposure chamber junction are the egress hatch of transferring cabin, are connected with out hatch door at the egress hatch.
5. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 1, feature
Be: the Biohazard Safety Equipment is multiple, including the first Biohazard Safety Equipment and the second Biohazard Safety Equipment, first bio-safety
The exposure chamber of cabinet is configured to place aerosol generating device, and it is sudden and violent that the exposure chamber of second Biohazard Safety Equipment is configured to placement mouth and nose
Reveal unit.
6. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 5, feature
Be: first Biohazard Safety Equipment is set as one, and second Biohazard Safety Equipment is set as multiple, and multiple described second
Mouth and nose exposure unit in Biohazard Safety Equipment is connect with the aerosol generating device of first Biohazard Safety Equipment.
7. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 6, feature
It is: the intracavitary aerosol generating device of the first Biohazard Safety Equipment exposure and multiple second Biohazard Safety Equipment exposure chambers
Interior mouth and nose exposure unit is connected by snorkel, and the snorkel is identical.
8. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 1, feature
It is:
The mouth and nose exposure unit includes animal seat, and the animal is removably mounted at the second Biohazard Safety Equipment with seat
Exposure is intracavitary；
Animal seat includes vehicle frame, the vehicle frame, head fixing device, upper limb fixing device, buttocks seat plate and lower limb
Fixed device, and the head fixing device, the upper limb fixing device, the buttocks seat plate and the lower limb fixing device are equal
Position is adjustably mounted in the vehicle frame in the vertical direction.
9. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 8, feature
Be: the mouth and nose exposure unit includes animal mouth and nose exposure component, and the mouth and nose exposure component includes shield, respiratory surface
Cover, suction line and discharge line；
The shield includes housing and sealing structure, and the housing has head insert port, so that the head of animal is via institute
Head insert port is stated to protrude into the shield；The sealing structure is installed on the head insert port, to seal the neck of animal
Region between portion and the head insert port；
The breathing mask is set in the shield, is configured to be installed on the face of animal；
The suction line and the discharge line are connected to the breathing mask, and negative pressure mouth is provided on the housing,
The negative pressure mouth is configured to connecting power device, so as to keep negative pressure state in the shield.
10. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 9, feature
Be: in being removably installed in backwards to upper limb fixing device side, the head is fixed to be filled the mouth and nose exposure component
It sets.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710845874.0A CN109512545B (en) | 2017-09-19 | 2017-09-19 | Biological safety type primate biological aerosol oral-nasal exposure system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710845874.0A CN109512545B (en) | 2017-09-19 | 2017-09-19 | Biological safety type primate biological aerosol oral-nasal exposure system |
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| Publication Number | Publication Date |
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| CN109512545A true CN109512545A (en) | 2019-03-26 |
| CN109512545B CN109512545B (en) | 2024-07-09 |
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| CN201710845874.0A Active CN109512545B (en) | 2017-09-19 | 2017-09-19 | Biological safety type primate biological aerosol oral-nasal exposure system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20210033703A (en) * | 2019-09-19 | 2021-03-29 | 한국산업안전보건공단 | Integrated inhalation exposure test device of portable type |
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| Publication number | Publication date |
|---|---|
| CN109512545B (en) | 2024-07-09 |
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