CN109498193A - A kind of dentistry implant and its with synosteosis performance verification method - Google Patents
A kind of dentistry implant and its with synosteosis performance verification method Download PDFInfo
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- CN109498193A CN109498193A CN201811459326.5A CN201811459326A CN109498193A CN 109498193 A CN109498193 A CN 109498193A CN 201811459326 A CN201811459326 A CN 201811459326A CN 109498193 A CN109498193 A CN 109498193A
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- dentistry implant
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
- A61C8/0022—Self-screwing
- A61C8/0025—Self-screwing with multiple threads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
- A61C8/0037—Details of the shape
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N3/22—Investigating strength properties of solid materials by application of mechanical stress by applying steady torsional forces
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/0014—Type of force applied
- G01N2203/0021—Torsional
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dentistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Ceramic Engineering (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
Abstract
The present invention relates to artificial tooth root technical fields, provide a kind of dentistry implant, comprising: the top end surface of from top to bottom integrated neck thread body and tapered thread body, neck thread body is equipped with limiting section.Invention additionally discloses a kind of dentistry implant and synosteosis performance verification method, including torsion-testing, Micro-CT analysis and histological stain, step includes animal packet, preparation of specimen and torsional test and etc..A kind of dentistry implant provided by the invention and its with synosteosis performance verification method, the antitorque rotation structure of limiting section is equipped in the top end surface of neck thread body, prevent base station from loosening, guarantee that base station connection long-term safety is reliable, and a kind of dentistry implant and synosteosis performance verification method are provided, scientific basic is provided for the quality testing and verifying of dentistry implant.
Description
Technical field
The present invention relates to artificial tooth root technical fields, test more particularly to a kind of dentistry implant and its with synosteosis performance
Card method.
Background technique
Nineteen fifty-two SwedenWith in titanium alloy implantation in rabbit ilium, the firm combining of titanium and bone is found, and in
In generation nineteen sixty, just starts the experimental study that titanium is applied to Dental implantion.Nineteen sixty-fiveStart titanium implant application
It being treated in the plantation of dentition defect, Switzerland Schroeder in 1976 has been unequivocally established synosteosis in histological presence for the first time, and
The reported success that plantation treatment has been carried out in 1977 formally proposes " synosteosis " (osseointegration) theory.Tooth
The development experience of implantology three phases: 1. based on experimental result.2. to expand idicatio as power.3. with clinic card
According to for foundation.
Implant system includes BLB, CDIC etc. in the prior art.BLB implant system lacks the design of anti-rotation structure, leads
After causing plantation to repair the several years, corona is easy to appear loosening, and reinforces to wear again and not fully return to original position into rear corona.
In addition, implant surface processing mode more falls behind, opportunity of bearing a heavy burden is about in the 5-6 month, 10 year's harvest underpowers 80%.Domestic mesh
Osseointegrated implants efficiency is evaluated in the systemic zoopery of preceding shortage, and previous planting body invention rests on structure design side mostly
Face.
Summary of the invention
(1) technical problems to be solved
The object of the present invention is to provide a kind of dentistry implant and its with synosteosis performance verification method, solve the prior art
Middle dental implant system lacks the design of anti-rotation structure, and after causing plantation to repair the several years, corona is easy to appear loosening, and again
The problem of not fully returning to original position into rear corona and lack experimental evaluation Osseointegrated implants performance, is worn in secondary reinforcing.
(2) technical solution
In order to solve the above technical problem, the present invention provides a kind of dentistry implants, comprising: integrated neck from top to bottom
The top end surface of threaded body and tapered thread body, the neck thread body is equipped with limiting section.
Wherein, the limiting section includes muti-piece limit plate, and the muti-piece limit plate is located at the inside of the neck thread body
And it is angularly distributed along the circumference of the neck thread body.
Wherein, arrange that micro- screw thread of 3-5 ring, adjacent micro- flight pitch are 0.3mm- on the neck thread body
0.4mm, the length of micro- screw thread are 1.5mm-1.7mm, and the depth of micro- screw thread is 0.15mm-0.25mm.
Wherein, the tapered thread body includes double thread, and is in Morse's taper constriction step by step.
Wherein, the spacing of the adjacent double thread is 1.1mm-1.3mm.
Wherein, the tip helicitic texture of the tapered thread body have several notches, the tip helicitic texture it is transversal
Face is in flabellum shape, and the tip end face of the tapered thread body is spherical.
Wherein, the material of the dentistry implant is titanium alloy T i2448, and anodized is passed through on surface.
Invention additionally discloses a kind of such as dentistry implant and synosteosis performance verification method of the invention, including torsion-testing
Step, the torsion-testing step include:
S1, animal packet: being directed to more experimental animals, pulls out dentistry implant, and experimental group and control group is arranged；
S2, preparation of specimen: retaining bone regeneration around implant attached gingiva, and number is fabricated to Saving specimen；
S3, torsional test: taking out the gingival former and closing screw of experimental group and control group planting body, and connection planting body is matched
Set torque tester is tested.
It wherein, further include that dentistry implant is implanted into different time points Micro-CT measuring process after animal mandibular, it is described
Different time points Micro-CT measuring process includes: after dentistry implant implantation animal mandibular
Step S1, animal packet and the step S2 of the torsion-testing, preparation of specimen and
S4, Micro-CT measurement method: sample carries out Micro-CT scanning after taking out, and scanning carries out Three-dimensional Gravity after completing
It builds, sclerotin around experimental group and control group planting body top 4mm is taken to be analyzed.
It wherein, further include that dentistry implant is implanted into different time points histological stain observation of steps after animal mandibular, institute
State dentistry implant implantation animal mandibular after different time points histological stain observation of steps include: the torsion-testing step
Rapid S1, animal packet and
S5, preparation of specimen: a) after experimental animal specimen sampling, shooting X-ray film positions planting body three-dimensional position, numbers, system
It is made Saving specimen；
B) Gradient elution using ethanol:；
C) chloroform is transparent；
D) immersion fluid infiltrates；
E) it embeds；
F) production sclerous tissues grinding；
G) methylene blue basic fuchsin dyes；
H) Toluidine blue staining；
I) tri- color of Goldner ' s.
(3) beneficial effect
A kind of dentistry implant provided by the invention and its with synosteosis performance verification method, at the top of neck thread body
End face is equipped with the antitorque rotation structure of limiting section, prevents base station from loosening, and guarantees that base station connection long-term safety is reliable, and provide a kind of tooth
Section's planting body and synosteosis performance verification method, provide scientific basic for the quality testing and verifying of dentistry implant.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of dentistry implant of the present invention；
Fig. 2 is the neck thread body schematic diagram of dentistry implant of the present invention；
Fig. 3 is the tapered thread body schematic diagram of dentistry implant of the present invention；
Fig. 4 is the limiting section structural schematic diagram of dentistry implant of the present invention；
Fig. 5 is the tapered thread body bottom schematic view of dentistry implant of the present invention；
Fig. 6 is the tapered thread body elevated bottom perspective structure chart of dentistry implant of the present invention；
Fig. 7 is that dentistry implant of the present invention is implanted into different time points Micro-CT experimental group and control group after animal mandibular
Histogram；
Fig. 8 is that dentistry implant of the present invention is implanted into different time points histology methylene blue basic fuchsin after animal mandibular
Coloration experiment group and control group observation figure；
Fig. 9 is that different time points histology Toluidine blue staining is tested after dentistry implant of the present invention is implanted into animal mandibular
Group and control group observation figure；
Figure 10 is that tri- color of different time points histology Goldner ' s is real after dentistry implant of the present invention is implanted into animal mandibular
Test group and to illumination observation figure.
In figure, 1, neck thread body；2, tapered thread body；3, limiting section.
Specific embodiment
With reference to the accompanying drawings and examples, specific embodiments of the present invention will be described in further detail.Following instance
For illustrating the present invention, but it is not intended to limit the scope of the invention.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can
To be mechanical connection, it is also possible to be electrically connected；It can be directly connected, can also can be indirectly connected through an intermediary
Connection inside two elements.For the ordinary skill in the art, above-mentioned term can be understood at this with concrete condition
Concrete meaning in invention.
As shown in Figure 1, the present invention discloses a kind of dentistry implant characterized by comprising integrated neck from top to bottom
The top end surface of threaded body 1 and tapered thread body 2, the neck thread body is equipped with limiting section 3.
Specifically, the present invention installs limiting section 3 in the top end surface of neck thread body 1, the base station pine for preventing top from connecting
It is dynamic, guarantee that base station connection long-term safety is reliable.
Wherein, the limiting section 3 includes muti-piece limit plate, and the muti-piece limit plate is located at the interior of the neck thread body 1
Portion is simultaneously angularly distributed along the circumference of the neck thread body.Specifically, the section of neck thread body 1 is cyclic structure, these
Limit plate is arranged in ring structure, is connected thereto the base station connected at the top of neck thread body 1 more firm, is avoided base station loose
Dynamic rotation, causes to fall off.As shown in figure 4, the limit plate of the present embodiment is four pieces, and the angle between adjacent limit plate is
90°.According to the actual situation, those skilled in the art can install other limit plates for needing quantity, such as the quantity of limit plate
It can be 2 pieces, 6 pieces etc..
Wherein, arrange that micro- screw thread of 4 rings, adjacent micro- flight pitch are 0.3mm- on the neck thread body 1
0.4mm, the length of micro- screw thread are 1.5mm-1.7mm, and the depth of micro- screw thread is 0.15mm-0.25mm.Such as Fig. 2 institute
Show, micro- helicitic texture that screw thread number of rings is 4 rings can be selected in the present embodiment, i.e., the screw thread of micro- helicitic texture is four, adjacent two
Micro- flight pitch is 0.35mm, and the length of micro- screw thread is 1.6mm, depth 0.2mm.Micro- helicitic texture of the present embodiment have with
Lower advantage: can be such that planting body and bone tissue contact surface area increases, and be conducive to improve Osseointegrated implants intensity；Neck portion design is micro-
In addition to the cutting of screw thread when increasing implantation and self tapping act on, the mechanical self-latching effect of screw thread can increase its initial planting and stablize screw thread
Property, while increasing planting body and bone tissue in region of stress concentration i.e. cortex bone EDGE CONTACT area, retain plantation to greatest extent
Body neck bone tissue reduces the unnecessary loss of bone tissue, reinforces the early stage maintenance of cortex bone, improve the success rate of implant denture
And long-term effect.
Wherein, the tapered thread body 2 includes double thread, and is in Morse's taper constriction step by step.Preferably, adjacent described
The spacing of double thread is 1.1mm-1.3mm.As shown in figure 3, the spacing of the present embodiment double thread is 1.2mm.Specifically, double
Line screw thread can shorten operation Implantation Time, increase bone contact area；Sharp screw thread has certain self tapping, is conducive to hard
Matter bone implant；Thread depth can bring good primary stability with bone density gradual change.
Wherein, the tip helicitic texture of the tapered thread body 2 have several notches, the tip helicitic texture it is transversal
Face is in flabellum shape, and the tip end face of the tapered thread body 2 is spherical.As shown in Figure 5 and Figure 6, the tip spiral shell of the present embodiment
Line have several notches, form Design become three sword cutting slots, i.e., opened up on the basis of helicitic texture there are three slot (i.e.
Notch), screw thread function is made it have, and can more preferably carry out bone cutting faster, enhance self tapping ability, improves plantation efficiency.
Specifically, four layer screw thread of the tapered thread body 2 of the present embodiment since its tip screw thread are three swords cutting slot structure, and it is sharp
Portion's helicitic texture constitutes drill lip form, and bottom sword retains top of the bone with drill lip only incision rather than by way of cutting
Lesser implantation path is needed, therefore jawbone damage can be reduced, retains bone to greatest extent；The processing of tip end face spherical surface, more
Smoothly, other than in addition to the biomethanics the considerations of, once tip is close or is pierced by cortical bone, nose bottom or Sinus floor, it is possible to reduce
Injury to surrounding tissue.
Wherein, the material of the dentistry implant is titanium alloy T i2448, and anodized is passed through on surface.The titanium closes
Intensity >=800MPa of gold, elasticity modulus≤60GPa, plasticity >=10% have good biocompatibility.Surface treatment uses
Anode oxidation method, the planting body are used acetone, ethyl alcohol and distilled water to be ultrasonically treated respectively 10 minutes, are spontaneously dried at room temperature.?
In the electrolyzing hydrofluoric acid liquid of 0.5% mass fraction, acid etching 30 minutes, dried immediately with deionized water flushing later.Then exist
In the electrolyzing hydrofluoric acid liquid of 0.2% mass fraction, with 20V ultor oxidation processes 40 minutes, high pressure steam sterilization.
Invention additionally discloses a kind of based on above-mentioned dentistry implant and synosteosis performance verification method, including torque measuring
Examination, the torsion-testing include:
S1, animal packet: more beasle dogs, it is minimally invasive before being implanted into dentistry implant to pull out bilateral lower jaw before first to fourth and grind
Tooth, carries out the implant operation of this dentistry implant experimental group and control group after three months, every side mandibular is implanted into 2 pieces of this teeth at random
Section's planting body and 1 piece of control group implant, postoperative beasle dog are put to death at random according to the time；
S2, preparation of specimen: after dog is put to death, mandibular is separated, retains bone regeneration around implant attached gingiva, along augnathus first molar
Cheek-tongue direction sawed-off mandibular manually in close, and it is cooling with physiological saline, and by every section of mandibular label, preservative film is wrapped, and is put in ice
In block, it is to be measured to be sent to laboratory；
S3, torsional test: using the mating packet of surgical tool, takes out the gingival former and envelope of experimental group and control group planting body
Screw is closed, the connection mating torque tester of planting body is tested.
The beasle dog selected in the step S1 of the present embodiment be 8 18 monthly age male beagle dogs, postoperative 8 beasle dogs according to
Time is randomly divided into 2 weeks, 4 weeks, 8 weeks, four groups of execution in 12 weeks.
The control group of dentistry implant and synosteosis performance verification method selection of the invention is Shi Zhuoman planting body (attached drawing
In using NI as the abbreviation of planting body of the invention, using ITI as the abbreviation of Shi Zhuoman planting body), and the method for putting to death meets
Animal welfare committee member may require that (ethics number: KQYY-2016YFC1102604).
Test result is as follows table (wherein t and p is statistics code name):
Analyze test result: planting body of the invention is of the invention at 2 weeks compared with Shi Zhuoman planting body
Planting body screws out torque and is slightly larger than control group, and the simultaneously no significant difference both at 4 weeks, 8 weeks, 12 weeks, illustrates kind of the invention
Implant in agglutination, primary stability lose degree it is lower compared with control group implant, and bear a heavy burden opportunity and early stage stability it is equal
Identical as control group implant, which has the initial stage ability to ward off risks more more reliable than control group implant on screwing out torque.
Dentistry implant and synosteosis performance verification method of the invention further includes dentistry implant implantation animal mandibular
Different time points Micro-CT measuring process afterwards, the present invention provide one embodiment, and step includes:
Step S1, animal packet and the step S2 of the torsion-testing, preparation of specimen and
S4, Micro-CT measurement method: sample carries out Micro-CT scanning after taking out, and scanning carries out Three-dimensional Gravity after completing
It builds, sclerotin around experimental group and control group planting body top 4mm is taken to be analyzed.Specifically, this Micro-CT measurement needs elder generation
The step of carrying out animal packet and preparation of specimen, operating with torsion-testing is identical, and the control group of the present embodiment is still scholar's Zhuo
Graceful planting body, instrument refers to when scanning: X-ray tube voltage: 80KV；Electric current: 500 μ A；Detector triggering mode: internal trigger；It differentiates
15 μm of rate；Split mode: Binning1；Output mode: 4 frames superposition；Project number: 500 visual angles, that is, every 0.72 degree of acquisition l frame figure
Picture.
Measure the analysis of C. bone intrinsic parameter:
I. diaphysis fraction (Bone Volume/Total Volume, as shown in fig. 7, referred to as: BV/TV)
Ii. long-pending ratio (the Bone Surface Area/Bone Volume, as shown in fig. 7, simple with bone volume of bone surface
Claim: BS/BV)
Iii. bone trabecula thickness (Trabecular Thickness, as shown in fig. 7, referred to as: Tb.Th)
Iv. bone trabecula quantity (Trabecular Number, as shown in fig. 7, referred to as: Tb.N)
V. bone trabecula separating degree (Trabecular Spacing, as shown in fig. 7, referred to as: Tb.Sp)
Micro-CT test result analysis:
Time shaft longitudinal comparison the result shows that, this dentistry implant and 4 weeks to 12 weeks indices of control group planting body are equal
Without obvious statistical difference, and there is within 2 and 4 weeks obvious statistical difference, after illustrating 4 weeks, dentistry implant and control group planting body
Weight bearing opportunity can be basically reached.Time shaft across comparison the result shows that, at 2 weeks, the bone trabecula number of this dentistry implant
To be more than control group, while the bone trabecula separating degree of this dentistry implant will be lower than control group.Should the result shows that, this dentistry plantation
For body at 2 weeks, osteoclast activity was slightly weaker than control group implant, this is also that it is able to maintain with stronger primary stability one
Big factor.
Dentistry implant and synosteosis performance verification method of the invention further includes dentistry implant implantation animal mandibular
Different time points histological stain observation of steps afterwards, the present invention provide a kind of embodiment, and step includes: the torsion-testing
Step S1, animal packet and
S5, preparation of specimen: a) after beasle dog bilateral mandibular specimen sampling, shooting X-ray film positions planting body three-dimensional position,
Sample is cut apart from bone regeneration around implant 2-3mm along each planting body cheek-tongue direction, and is numbered, 10% 4 DEG C of formalin fixes 3
It, flowing water rinses overnight, removes formalin in tissue；
B) Gradient elution using ethanol: sample is put into 90% alcohol 24 hours and is dehydrated after dehydration in 70% alcohol 24 hours, and
Successively it is put into 95% alcohol 30 hours, 95% alcohol 30 hours, 100% alcohol 24 hours, 100% alcohol 24 hours, 100% wine
Essence 24 hours carries out Gradient elution using ethanol；
C) chloroform is transparent: 3 times, each duration is respectively for 24 hours；
D) infiltrate: sample dehydration after 2d is impregnated in immersion fluid I, II, III, immersion fluid needs Fresh, in 4 DEG C into
Row；Wherein: immersion fluid I: methyl methacrylate and dibutyl phthalate are with the mixing of 5:1 ratio, magnetic stirrer
2h；Immersion fluid II and III: methyl methacrylate and dibutyl phthalate are mixed with 5:1 ratio, in every 100ml liquid
Benzoyl peroxide 2g, magnetic stirrer 4h is added；
E) it embeds: the polymerization inhibitor in removal finished product methyl methacrylate, by 1:l finished product methyl methacrylate and 5%
Sodium hydroxide separatory funnel is added, fully shake, static layering back leak abandons lower liquid, 3 times repeatedly, then with distilled water with same
Quadrat method is washed 3 times, and sodium hydroxide in liquid is removed, and anhydrous calcium chloride is then added into separatory funnel, and several minutes of concussion mixing is inhaled
Except moisture content, filter paper filtering removal calcium chloride；Upper layer filtrate is collected in bottle, saves backup in 4 DEG C of refrigerators；It removes except polymerization inhibitor
Methyl methacrylate monomer 95ml, it is resistance to be put into wide opening by dibutyl phthalate 5ml, anhydrous benzoyl peroxide 4.0g
In thermoplastic materials bottle, it is put into magnetic rotor, constant temperature water bath in hot water cup is placed in and heats, constant temperature is maintained at 50 DEG C, is placed in magnetic agitation
Device stirs 2h；It is down to room temperature to liquid, labelled be placed in 4 DEG C of refrigerators saves backup；Sample tissue is taken out from immersion fluid III
Block is simultaneously put into that bottom is flat, wall is thin, does in clean glass embedding bottle, respectively after marker number, a certain amount of embedding liquid is added, vacuumizes
2h, adds bottle cap ambient temperature overnight, and first contact pin was then placed in water bath and was polymerize to radiate and to deflate on embedding bottle cap next day,
Gradually improve the temperature of water bath, polymerization time 3 stage by stage from 32 DEG C -36 DEG C -42 DEG C -48 DEG C according to the process of organization embedding
~4d；
F) production sclerous tissues grinding: sample is pasted on plastic sheet after embedding, grinds group using sclerous tissues' wafer lapping machine
Another plastic sheet is pasted in tissue surface by surface of second order with ancient 7100 bonding die glue of Sha, with the strength of vacuum suction by tissue adsorptions in
Slicer adjusts thickness, is cut into 100-200 μm of slab；It will be cut on wafer lapping machine with 800 mesh, the mating sand paper of 1200 mesh
Then slice lapping is polished to 30 μm with 4000 mesh sand paper；
G) methylene blue basic fuchsin dyeing (as shown in Figure 8)
(1) methylene blue dye liquor, 60 DEG C of water-baths are dyed 15 minutes, and filter paper blots dye liquor；
(2) aquae destillata rinses, air drying；
(3) basic fuchsin dye liquor is drawn in tissue with suction pipe, dye 5 minutes, filter paper blots dye liquor；
(4) 95%, 100% dehydration of alcohol, dimethylbenzene is transparent, then resin mounting；
H) Toluidine blue staining (as shown in Figure 9)
(1) 2% toluidine blue liquid dyes 10 minutes；
(2) citrate phosphate buffer rinses 2 times (each 1 minute)；
(3) filter paper wipe dry；
(4) dehydration of alcohol, dimethylbenzene is transparent, then resin mounting；
I) tri- color of Goldner ' s (as shown in Figure 10)
(1) slice is de- moulds to water, Weigert ' s Garapa element liquid 15 minutes；
(2) aquae destillata rinses 1 time；
(3) tap water flowing water rinses 15 minutes；
(4) aquae destillata rinses 1 time；
(5) Ponceaux acid fuchsin liquid contaminates 15 minutes；
(6) 1% acetic acid rinse 2 times；
(7) phosphotungstic acid-orange G 8 minutes；
(8) 1% acetic acid rinse 2 times；
(9) toluidine blue liquid 15 minutes；
(10) 1% acetate solutions rinse 2 times；
(11) 70% ethyl alcohol rinse 1 time；
(12) 100% ethyl alcohol I, II are rinsed 2 times；
(13) dimethylbenzene is transparent, then resin mounting.
Interpretation of result: as shown in figure 8, when methylene blue basic fuchsin dyes visible dentistry implant and control group 2 weeks
There are a large amount of osteoclasts, and this dentistry implant is slightly active compared with control group implant bone remodeling activity；After 4 weeks osteoclast by
Fade mistake, and the new and old bone boundary of this dentistry implant is unintelligible, and control group bone remodeling activity is more active；After 8 weeks to 12 weeks, bone
In reconstruction activity still carries out, but osteoclast and osteoblast are more rare at this time, and beam occur in two groups of implant
Shape bone and Harvard formula system.
As shown in figure 9, there is apparent bone resorption when visible dentistry implant of Toluidine blue staining and control group 2 weeks
Lacuna, new bone are presented apparent navy blue, old bone be it is light blue, osteoblast and osteoclast carry out bone remodeling activity jointly.4
Area of new bone largely occurs and gradually replaces old bone when all, illustrates that Osteoblastic activity is more active；The boundary of 8 Zhou Houxin bones and mature bone
It fades away, bundle bone and a small amount of Harvard formula system occurs, control group is close to implant surface and one layer of mineralising bone, but mine also occurs
It is not especially close for connecting between change bone and old bone.Two groups of new bones of implant are gradually obscured with mature bone boundary after 12 weeks, it is seen that more
More Harvard formula systems.
As shown in Figure 10, when tri- color of Goldner ' s is 2 weeks visible, this dentistry implant and control group implant are visible a large amount of
Skeletonization, osteoclast, partial region form Bone resoiption pit；4 Zhou Shiben dentistry implants and the still visible bone remodeling of control group are living
Dynamic, there is apparent mineralized bone matrix in control group；8 weeks to 12 weeks, it is seen that osteoblast, osteoclast disappear substantially, osteoid
It is more obvious with mineralising bone.
A kind of dentistry implant provided by the invention and its with synosteosis performance verification method, at the top of neck thread body
End face is equipped with the antitorque rotation structure of limiting section, prevents base station from loosening, and guarantees that base station connection long-term safety is reliable, and provide a kind of tooth
Section's planting body and synosteosis performance verification method, provide scientific basic for the quality testing and verifying of dentistry implant.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of dentistry implant characterized by comprising from top to bottom integrated neck thread body and tapered thread body, institute
The top end surface for stating neck thread body is equipped with limiting section.
2. dentistry implant as described in claim 1, which is characterized in that the limiting section includes muti-piece limit plate, described more
Block limit plate is located at the inside of the neck thread body and is angularly distributed along the circumference of the neck thread body.
3. dentistry implant as described in claim 1, which is characterized in that micro- screw thread of 4 rings is arranged on the neck thread body,
Adjacent micro- flight pitch is 0.3mm-0.4mm, and the length of micro- screw thread is 1.5mm-1.7mm, the depth of micro- screw thread
Degree is 0.15mm-0.25mm.
4. dentistry implant as described in claim 1, which is characterized in that the tapered thread body includes double thread, and is in
Morse's taper constriction step by step.
5. dentistry implant as claimed in claim 4, which is characterized in that the spacing of the adjacent double thread is 1.1mm-
1.3mm。
6. dentistry implant as described in claim 1, which is characterized in that the tip helicitic texture of the tapered thread body has
The cross section of several notches, the tip helicitic texture is in flabellum shape, and the tip end face of the tapered thread body is spherical.
7. the dentistry implant as described in any one of claim 1-6, which is characterized in that the material of the dentistry implant
For titanium alloy T i2448, and anodized is passed through on surface.
8. a kind of dentistry implant as described in any one of claim 1-7 and synosteosis performance verification method, feature
It is, including torsion-testing step, the torsion-testing step includes:
S1, animal packet: being directed to more experimental animals, pulls out dentistry implant, and experimental group and control group is arranged；
S2, preparation of specimen: retaining bone regeneration around implant attached gingiva, and number is fabricated to Saving specimen；
S3, torsional test: the gingival former and closing screw of experimental group and control group planting body are taken out, the mating torsion of planting body is connected
Square tester is tested.
9. dentistry implant as claimed in claim 8 and synosteosis performance verification method, which is characterized in that further include dentistry kind
Implant is implanted into different time points Micro-CT measuring process after animal mandibular, after the dentistry implant is implanted into animal mandibular
Different time points Micro-CT measuring process includes:
Step S1, animal packet and the step S2 of the torsion-testing, preparation of specimen and
S4, Micro-CT measurement method: sample carries out Micro-CT scanning after taking out, and scanning carries out three-dimensional reconstruction after completing, takes
Sclerotin is analyzed around experimental group and control group planting body top 4mm.
10. dentistry implant as claimed in claim 8 and synosteosis performance verification method, which is characterized in that further include dentistry
Planting body is implanted into different time points histological stain observation of steps after animal mandibular, and the dentistry implant is implanted into animal lower jaw
After bone different time points histological stain observation of steps include: the step S1 of the torsion-testing, animal packet and
S5, preparation of specimen: a) after experimental animal specimen sampling, shooting X-ray film positions planting body three-dimensional position, and number is fabricated to
Saving specimen；
B) Gradient elution using ethanol:；
C) chloroform is transparent；
D) immersion fluid infiltrates；
E) it embeds；
F) production sclerous tissues grinding；
G) methylene blue basic fuchsin dyes；
H) Toluidine blue staining；
I) tri- color of Goldner ' s.
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