CN109490535B - Multichannel synchronous immunochromatography detection system and detection method - Google Patents
Multichannel synchronous immunochromatography detection system and detection method Download PDFInfo
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- CN109490535B CN109490535B CN201811231891.6A CN201811231891A CN109490535B CN 109490535 B CN109490535 B CN 109490535B CN 201811231891 A CN201811231891 A CN 201811231891A CN 109490535 B CN109490535 B CN 109490535B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
Abstract
The invention discloses a multichannel synchronous immunochromatographic detection system and a detection method, and relates to the technical field of test kits, the system comprises a box body and test strips, the box body is provided with a first sample adding hole and a plurality of observation windows, and a second sample adding hole is arranged between the first sample adding hole and each observation window; a plurality of percolation channels are arranged on the test strip, and the percolation channels pass through the first sample adding hole, the observation window and the lower part of the second sample adding hole; the device also comprises a motion mechanism, a photoelectric detector and a control computer, wherein the motion mechanism is used for driving the box body to do linear motion; the photoelectric detector outputs the detection result to the control computer in the form of an electric signal; and the control computer receives the detection result transmitted by the photoelectric detector to obtain the detection result of each detected sample on the test strip. Not only can realize rapid and accurate multi-channel immunochromatography detection, but also can select different detection antibodies according to a sample to be detected.
Description
Technical Field
The invention relates to the technical field of test kits, in particular to a multi-channel synchronous immunochromatography detection system and a detection method.
Background
The immunochromatographic test strip applies an advanced immuno-gold chromatography (GICA) technology to detect pathogens in normal body fluid and substances with extremely low normal content and abnormally increased under special conditions. At present, the reagent is widely applied to the rapid detection and preliminary screening of diseases such as schistosomiasis, hepatitis B, AIDS, syphilis and the like in clinic. The principle of the immunogold chromatography technology is that a microporous filter membrane is used as a carrier, a liquid sample dripped on one side of a membrane strip slowly permeates to the other end of the microporous filter membrane by utilizing the capillary action of the microporous filter membrane, and if specific antigens or antibodies exist in the liquid, the specific antigens or antibodies can be combined with immunogold and then combined with corresponding antibodies or antigens fixed on the microporous filter membrane to display the color of the immunogold.
However, the conventional immunogold chromatography is usually applied to detecting samples in a naked test strip mode, mostly adopts single index detection, needs repeated operation when multiple indexes of the samples are detected simultaneously, is not beneficial to improving the working efficiency more quickly, and is not beneficial to eliminating detection errors existing among the detection of the samples.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a multi-channel synchronous immunochromatographic detection system and a detection method, which can realize rapid, accurate and synchronous multi-channel immunochromatographic detection.
In order to achieve the above purposes, the technical scheme adopted by the invention is as follows: a multi-channel simultaneous immunochromatographic detection system comprising:
the box body is provided with a first sampling hole and a plurality of observation windows, and a second sampling hole is arranged between each observation window and the first sampling hole;
the test strip is fixed in the box body, a percolation channel is arranged at the corresponding position below each observation window on the test strip, and the percolation channel sequentially passes through the positions below the first sample adding hole, the observation window and the second sample adding hole;
the moving mechanism is fixed below the box body and is used for driving the box body to perform linear motion;
the photoelectric detector is arranged above the test strip and used for detecting the detection result on the test strip and outputting the detection result to the control computer in the form of an electric signal;
the control computer is used for controlling the motion mechanism to perform linear motion; and the photoelectric detector is also used for receiving the detection result transmitted by the photoelectric detector and processing data to obtain the detection result of each detected sample on the test strip.
On the basis of the scheme, the photoelectric detector is provided with an angle adjuster, and the angle adjuster is used for adjusting the angle of the photoelectric detector so as to respectively collect the detection results of different observation windows.
On the basis of the scheme, the photoelectric detector comprises a photoelectric detection assembly, a signal amplifier and a filter circuit.
On the basis of the scheme, the test strip is formed by sequentially connecting a sample pad, a gold-labeled conjugate pad and a reaction film, wherein the reaction film is a nitrocellulose film printed with a hidden detection line and a contrast line.
On the basis of the scheme, the sample pad is arranged under the first sample adding hole, the gold-labeled conjugate pad is arranged under the second sample adding hole, and the reaction film is arranged under the observation window.
On the basis of the scheme, the percolation channel comprises a first channel arranged above the sample pad, a second channel arranged above the gold-labeled conjugate pad and a third channel arranged above the reaction membrane, and the first channel is sequentially connected with the second channel and the third channel.
On the basis of the scheme, a plurality of steps are arranged at the connecting position of the second channel and the third channel.
On the basis of the scheme, 3-6 observation windows are arranged on the detection box, and 3-6 percolation channels are correspondingly arranged on the test strip.
The invention also provides a multichannel synchronous immunochromatographic detection method adopting the multichannel synchronous immunochromatographic detection system, which comprises the following steps:
adding a sample to be detected into the first sample adding hole;
adding a detection antibody into the second sample adding hole;
the control computer controls the motion mechanism to start linear motion;
the photoelectric detector detects the detection result on the test strip and outputs the detection result to the control computer in the form of an electric signal;
the control computer receives the detection result transmitted by the photoelectric detector, and performs data processing to obtain the detection result of each detected sample on the test strip;
and the control computer controls the motion mechanism to finish linear motion.
On the basis of the scheme, the method further comprises the following steps:
the photoelectric detector is provided with an angle adjuster, and the angle adjuster is used for adjusting the angle of the photoelectric detector so as to respectively collect detection results of different observation windows;
storing an adjustment judgment threshold S% in the control computer;
the control computer judges whether the detection result of the detection line and the detection result of the comparison line are both greater than an adjustment judgment threshold S%; if the angle of the photoelectric detector is larger than the preset angle, adjusting the angle of the photoelectric detector through the angle adjuster to enable the photoelectric detector to acquire the detection result of the next observation window until the detection results of all the observation windows are acquired;
if the linear motion is smaller than the preset linear motion threshold, the control computer controls the motion mechanism to finish the linear motion, finish the detection and report an error.
Compared with the prior art, the invention has the advantages that:
(1) the invention provides a multichannel synchronous immunochromatographic assay detection system, which comprises a box body and test strips, wherein the box body is provided with a first sample adding hole and a plurality of observation windows, and a second sample adding hole is arranged between the first sample adding hole and each observation window; a plurality of percolation channels are arranged on the test strip, and the percolation channels pass through the first sample adding hole, the observation window and the lower part of the second sample adding hole; the device also comprises a motion mechanism, a photoelectric detector and a control computer, wherein the motion mechanism is used for driving the box body to do linear motion; the photoelectric detector outputs the detection result to the control computer in the form of an electric signal; and the control computer receives the detection result transmitted by the photoelectric detector to obtain the detection result of each detected sample on the test strip. Not only can realize rapid and accurate multi-channel immunochromatography detection, but also can select different detection antibodies according to a sample to be detected. The sample to be detected is added into the first sample adding hole, and the detection antibody is added into the second sample adding hole, so that not only can the multichannel immunochromatography detection be rapidly and accurately carried out, but also different detection antibodies can be selectively added according to the sample to be detected.
(2) The percolation channel comprises a first channel arranged above the sample pad, a second channel arranged above the gold-labeled conjugate pad and a third channel arranged above the reaction membrane, and the first channel is sequentially connected with the second channel and the third channel. The connecting part of the second channel and the third channel is provided with a plurality of steps, so that samples in the second channels can overflow the steps and enter the third channel for reaction after reaching the same height, and multi-channel immunochromatography detection can be synchronously performed.
(3) The invention also provides a multi-channel synchronous immunochromatographic assay detection method, wherein a sample to be detected is added into the first sample adding hole; adding a detection antibody into the second sample adding hole; controlling a computer to control a motion mechanism to start linear motion; the photoelectric detector detects the detection result on the test strip and outputs the detection result to the control computer in the form of an electric signal; the control computer receives the detection result transmitted by the photoelectric detector and processes data to obtain the detection result of each detected sample on the test strip; and the multichannel immunochromatographic assay can be rapidly and accurately carried out.
(4) The photoelectric detector is provided with an angle adjuster, and the angle adjuster is used for adjusting the angle of the photoelectric detector so as to respectively collect the detection results of different observation windows; storing an adjustment judgment threshold S% in a control computer; the control computer judges whether the detection result of the detection line and the detection result of the comparison line are both greater than an adjustment judgment threshold S%; if the angle of the photoelectric detector is larger than the preset angle, the angle of the photoelectric detector is adjusted through the angle adjuster, so that the photoelectric detector collects the detection result of the next observation window until the detection results of all the observation windows are collected, and the multichannel detection and analysis are automatically completed.
Drawings
FIG. 1 is a schematic structural diagram of a multi-channel synchronous immunochromatography detection system in an embodiment of the present invention.
FIG. 2 is a schematic structural diagram of a cartridge of the multi-channel synchronous immunochromatography detection system in the embodiment of the present invention;
fig. 3 is a schematic structural diagram of a test strip of the multi-channel synchronous immunochromatographic detection system in the embodiment of the present invention.
In the figure: 1-box body, 2-test paper strip, 3-first sample adding hole, 4-second sample adding hole, 5-observation window, 6-first channel, 7-second channel, 8-third channel, 9-movement mechanism, 10-photoelectric detector and 11-control computer.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and examples.
Example 1:
referring to fig. 1, an embodiment of the present invention provides a multichannel synchronous immunochromatographic detection system, including a box 1, a test strip 2, a movement mechanism 9, a photodetector 10, and a control computer 11:
referring to fig. 1 and 2, a first sample adding hole 3 and a plurality of observation windows 5 are arranged on a box body 1, and a second sample adding hole 4 is arranged between the first sample adding hole 3 and each observation window 5;
referring to fig. 1 and 3, a percolation channel is arranged at a corresponding position below each observation window 5 on the test strip 2, and the percolation channel sequentially passes through the positions below the first sample adding hole 3, the observation window 5 and the second sample adding hole 4.
The moving mechanism 9 is fixed below the box body 1, and is used for driving the box body 1 to perform linear motion;
the photoelectric detector 10 is arranged above the test strip 2, and is used for detecting the detection result on the test strip 2 and outputting the detection result to the control computer 11 in the form of an electric signal;
the control computer 11 is used for controlling the movement mechanism 9 to do linear movement; and is further configured to receive the detection result transmitted by the photodetector 10, and perform data processing to obtain the detection result of each detected sample on the test strip 2.
The multichannel synchronous immunochromatographic detection system provided by the embodiment of the invention comprises a box body 1 and a test strip 2, wherein the box body 1 is provided with a first sample adding hole 3 and a plurality of observation windows 5, and a second sample adding hole 4 is arranged between the first sample adding hole 3 and each observation window 5; a plurality of percolation channels are arranged on the test strip 2 and pass through the first sampling hole 3, the observation window 5 and the lower part of the second sampling hole 4; the device also comprises a movement mechanism 9 for driving the box body 1 to do linear movement, a photoelectric detector 10 and a control computer 11; the photoelectric detector 10 outputs the detection result to the control computer 11 in the form of an electric signal; the control computer 11 receives the detection result transmitted by the photoelectric detector 10 to obtain the detection result of each detected sample on the test strip 2, so that not only can the multichannel immunochromatography detection be rapidly and accurately performed, but also different detection antibodies can be selectively added according to the sample to be detected. The sample to be detected is added into the first sample adding hole 3, and the detection antibody is added into the second sample adding hole 4, so that not only can the multichannel immunochromatography detection be rapidly and accurately carried out, but also different detection antibodies can be selectively added according to the sample to be detected.
The test strip 2 is formed by connecting a sample pad, a gold-labeled conjugate pad and a reaction film in sequence, wherein the reaction film is a nitrocellulose film printed with an invisible detection line and a contrast line. The sample pad is arranged right below the first sample adding hole 3, the gold-labeled conjugate pad is arranged right below the second sample adding hole 4, and the reaction film is arranged right below the observation window 5. The percolation channel comprises a first channel 6 arranged above the sample pad, a second channel 7 arranged above the gold-labeled conjugate pad and a third channel 8 arranged above the reaction membrane, wherein the first channel 6 is sequentially connected with the second channel 7 and the third channel 8. A plurality of steps are arranged at the connecting position of the second channel 7 and the third channel 8. 3 ~ 6 observation windows 5 are equipped with on the detection box, correspond on the test paper strip 2 and be equipped with 3 ~ 6 infiltration passageways.
The percolation channel comprises a first channel 6 arranged above the sample pad, a second channel 7 arranged above the gold-labeled conjugate pad and a third channel 8 arranged above the reaction membrane, wherein the first channel 6 is sequentially connected with the second channel 7 and the third channel 8. The connecting part of the second channel 7 and the third channel 8 is provided with a plurality of steps, so that samples in the second channels 7 can overflow the steps after reaching the same height and enter the third channel 8 for reaction, and synchronous multichannel immunochromatography detection is realized.
The photodetector 10 includes a photodetector assembly, a signal amplifier, and a filter circuit. The photoelectric detector 10 is provided with an angle adjuster, and the angle adjuster is used for adjusting the angle of the photoelectric detector 10 so as to respectively collect the detection results of different observation windows 5; and the automatic completion of multi-channel detection and analysis is realized.
Example 2:
the embodiment of the invention also provides a multichannel synchronous immunochromatographic detection method using the multichannel synchronous immunochromatographic detection system of embodiment 1, which comprises the following steps:
adding a sample to be detected into the first sample adding hole 3;
adding a detection antibody into the second sample adding hole 4;
the control computer 11 controls the motion mechanism 9 to start linear motion;
the photoelectric detector 10 detects the detection result on the test strip 2 and outputs the detection result to the control computer 11 in the form of an electric signal;
the control computer 11 receives the detection result transmitted by the photoelectric detector 10, and performs data processing to obtain the detection result of each detected sample on the test strip 2;
the control computer 11 controls the movement mechanism 9 to end the linear movement.
The method further comprises the following steps:
the photoelectric detector 10 is provided with an angle adjuster, and the angle adjuster is used for adjusting the angle of the photoelectric detector 10 so as to respectively collect the detection results of different observation windows 5;
storing an adjustment judgment threshold value S% in the control computer 11;
the control computer 11 judges whether the detection result of the detection line and the detection result of the comparison line are both greater than an adjustment judgment threshold value S%; if the angle is larger than the preset value, the angle of the photoelectric detector 10 is adjusted through the angle adjuster, so that the photoelectric detector 10 collects the detection result of the next observation window 5 until the detection result of the complete observation window 5 is collected;
if the detected value is less than the predetermined value, the control computer 11 controls the motion mechanism 9 to end the linear motion, end the detection and report an error. And the automatic completion of multi-channel detection and analysis is realized.
The present invention is not limited to the above-described embodiments, and it will be apparent to those skilled in the art that various modifications and improvements can be made without departing from the principle of the present invention, and such modifications and improvements are also considered to be within the scope of the present invention. Those not described in detail in this specification are within the skill of the art.
Claims (7)
1. A multi-channel simultaneous immunochromatographic detection system, comprising:
the box body (1), wherein a first sample adding hole (3) and a plurality of observation windows (5) are arranged on the box body (1), and a second sample adding hole (4) is arranged between each observation window (5) and the first sample adding hole (3);
the test strip (2) is fixed in the box body (1), a percolation channel is arranged at the corresponding position below each observation window (5) on the test strip (2), and the percolation channel sequentially passes through the positions below the first sample adding hole (3), the observation windows (5) and the second sample adding hole (4);
the moving mechanism (9), the said moving mechanism (9) is fixed to the said box body (1) below, is used for driving the said box body (1) to carry on the linear motion;
the photoelectric detector (10) is arranged above the test strip (2) and used for detecting the detection result on the test strip (2) and outputting the detection result to the control computer (11) in the form of an electric signal;
the control computer (11), the said control computer (11) is used for controlling the said kinematic mechanism (9) to carry on the rectilinear motion; the device is also used for receiving the detection result transmitted by the photoelectric detector (10) and processing data to obtain the detection result of each detected sample on the test strip (2);
the test strip (2) consists of a sample pad, a gold-labeled conjugate pad and a reaction film, wherein the reaction film is a nitrocellulose film printed with a hidden detection line and a contrast line;
the percolation channel comprises a first channel (6) arranged above the sample pad, a second channel (7) arranged above the gold-labeled conjugate pad and a third channel (8) arranged above the reaction membrane, and the first channel (6) is sequentially connected with the second channel (7) and the third channel (8);
a plurality of steps are arranged at the connecting position of the second channel (7) and the third channel (8).
2. The multi-channel simultaneous immunochromatography detection system according to claim 1, wherein: the photoelectric detector (10) is provided with an angle adjuster, and the angle adjuster is used for adjusting the angle of the photoelectric detector (10) so as to respectively collect the detection results of different observation windows (5).
3. The multi-channel simultaneous immunochromatography detection system according to claim 1, wherein: the photodetector (10) includes a photodetector assembly, a signal amplifier, and a filter circuit.
4. The multi-channel simultaneous immunochromatography detection system according to claim 1, wherein: the sample pad is arranged under the first sample adding hole (3), the gold-labeled conjugate pad is arranged under the second sample adding hole (4), and the reaction film is arranged under the observation window (5).
5. The multi-channel simultaneous immunochromatography detection system according to claim 1, wherein: the detection kit is provided with 3-6 observation windows (5), and the test strip (2) is correspondingly provided with 3-6 percolation channels.
6. A multi-channel synchronous immunochromatography detection method using the multi-channel synchronous immunochromatography detection system according to any one of claims 1 to 5, for non-disease detection, comprising the steps of:
a sample to be detected is added into the first sample adding hole (3);
adding a detection antibody into the second sample adding hole (4);
the control computer (11) controls the motion mechanism to start linear motion;
the photoelectric detector (10) detects the detection result on the test strip (2) and outputs the detection result to the control computer (11) in the form of an electric signal;
the control computer (11) receives the detection result transmitted by the photoelectric detector (10) and processes data to obtain the detection result of each detected sample on the test strip (2);
and the control computer (11) controls the motion mechanism to finish linear motion.
7. The multi-channel synchronous immunochromatographic detection method of claim 6, further comprising the steps of:
the photoelectric detector (10) is provided with an angle adjuster, and the angle adjuster is used for adjusting the angle of the photoelectric detector (10) so as to respectively collect the detection results of different observation windows (5);
storing an adjustment judgment threshold S% in the control computer (11);
the control computer (11) judges whether the detection result of the detection line and the detection result of the comparison line are both greater than an adjustment judgment threshold S%; if the angle of the photoelectric detector (10) is larger than the preset value, adjusting the angle of the photoelectric detector (10) through the angle adjuster to enable the photoelectric detector (10) to collect the detection result of the next observation window (5) until the detection results of all the observation windows (5) are collected;
if the linear motion is smaller than the preset linear motion threshold, the control computer (11) controls the motion mechanism to finish the linear motion, finish the detection and report an error.
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| CN110275019A (en) * | 2019-08-01 | 2019-09-24 | 郑州迈迪迅医疗科技有限公司 | A kind of novel chromatography detection kit |
| CN111624331A (en) * | 2020-05-22 | 2020-09-04 | 军事科学院系统工程研究院卫勤保障技术研究所 | Multichannel synchronous fluorescence immunochromatography detection system |
| CN114965995B (en) * | 2022-05-20 | 2023-04-11 | 河南申友医学检验所有限公司 | Immunochromatography analysis detection system and method |
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