CN109486209A - A kind of haemodialysis extracorporeal circulation pipeline material and preparation method thereof - Google Patents
A kind of haemodialysis extracorporeal circulation pipeline material and preparation method thereof Download PDFInfo
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- CN109486209A CN109486209A CN201811259364.6A CN201811259364A CN109486209A CN 109486209 A CN109486209 A CN 109486209A CN 201811259364 A CN201811259364 A CN 201811259364A CN 109486209 A CN109486209 A CN 109486209A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
- C08G81/02—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
- C08G81/024—Block or graft polymers containing sequences of polymers of C08C or C08F and of polymers of C08G
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08L87/00—Compositions of unspecified macromolecular compounds, obtained otherwise than by polymerisation reactions only involving unsaturated carbon-to-carbon bonds
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- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08L2203/18—Applications used for pipes
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Abstract
The invention discloses a kind of preparation methods of haemodialysis extracorporeal circulation pipeline material, include the following steps: (one) (4Z) -4- [(E) -3- [3- carboxyl -5- oxo -1- (2,2,2- trifluoroethyls) -2H- pyrazoles -4- base] propyl- 2- alkene subunit] -5- oxo -1- (2,2,2- trifluoroethyl) pyrazoles -3- carboxylic acid, ethylene -1,1,2,2- tetrabasic carboxylic acid tetrasodium salt, 1, the copolymerization of 2,2- trifluoro vinyl tri-phenyl-silanes；(2) preparation of vinyl modified polyurethane；(3) processing and forming.The invention also discloses the haemodialysis extracorporeal circulation pipeline materials being prepared according to the preparation method of the haemodialysis extracorporeal circulation pipeline material.Haemodialysis extracorporeal circulation pipeline disclosed by the invention has good biocompatibility with material, and teratogenesis is not carcinogenic, does not cause allergic reaction；Low with excellent blood compatibility, hemolytic, anticoagulant property is good, and resist chemical, wear-resisting, mechanical mechanics property is excellent, and processing flowability is good.
Description
Technical field
The present invention relates to medical material tech field more particularly to a kind of haemodialysis extracorporeal circulation pipeline material and its
Preparation method.
Background technique
The basic function of kidney is excretion metabolism waste and moisture, will lead to metabolic waste and moisture with chronic kidney disease
The series sings and symptoms such as retention, the life of crisis patient.End-stage renal disease patient needs to carry out renal replacement therapies.Blood
Dialysis is exactly a kind of effective renal replacement therapies mode, it is an effluent low to concentration from a highly concentrated side using solute
Blood and both solution of dialyzate are introduced the dialyzer with hollowfibre semi-permeable membrance by dynamic principle simultaneously, allow blood position
In the side of hollowfibre semi-permeable membrance, dialyzate is located at the other side of hollowfibre semi-permeable membrance, makes the solution of film two sides by more
Dissipate and osmosis, come remove in blood of human body, small molecule toxins, meanwhile, the electrolyte in blood can also pass through infiltration
Effect reaches balance thoroughly, to achieve the purpose that realize blood purification.
China is had the thousands of Chronic Renal Failure Patients to need every year and is sustained life with conventional hemodialysis at present, and is had
The trend increased year by year.In blood dialysis, extracorporeal circulation pipeline is needed to realize the feedback of blood, when blood and in vitro
When circulation line contacts, plasma proteins can adsorb rapidly and be deposited on extracorporeal circulation pipeline inner surface, be easy to produce Coagulation test,
Insoluble fibrin and blood platelet can make blood clotting, form thrombus, therefore, the formation of thrombus in order to prevent, to blood
More stringent requirements are proposed for the performance of dialysis extracorporeal circulation pipeline material, does not require nothing more than its resist chemical, wear-resisting, Yi Sheng
It produces, also requires it low with good blood compatibility, hemolytic, anticoagulant property is good.
Haemodialysis extracorporeal circulation pipeline commonly used in the prior art is mainly medical PVC material, this material with material
It is easy with excellent resist chemical, wear-resisting, machine-shaping, but that there is hydrophilies is poor, easily absorption drug and sticks carefully
The biocompatibility issues such as bacterium, and blood compatibility problem when blood Long Term Contact, these problems all limit its application and
Development.As an improvement, the prior art is by carrying out the modified blood compatibility to improve material in surface, including improvement table to material
Parent/hydrophobic performance, distribution of charges, the micro phase separation structure in face, but this method is since modification can be to material matrix structure and property
It can impact, modified to improve cost and complex process degree again, therefore, this method could not also obtain in clinical application
It promotes and applies.
Therefore, need to develop one kind with good biocompatibility, teratogenesis is not carcinogenic, does not cause allergic reaction；It is excellent
Blood compatibility, hemolytic it is low, the good haemodialysis extracorporeal circulation pipeline material of anticoagulant property.
Summary of the invention
In order to overcome the shortcomings in the prior art, the present invention provide a kind of haemodialysis extracorporeal circulation pipeline material and its
Preparation method, should preparation method is simple, preparation cost is cheap, be more suitable for it is practical, and with the utility value in industry；
There is good biocompatibility by the effective material of haemodialysis extracorporal circulatory system that the preparation method is prepared, teratogenesis does not cause
Cancer does not cause allergic reaction；Excellent blood compatibility, hemolytic are low, and anticoagulant property is good, and resist chemical, wear-resisting, mechanical
Excellent in mechanical performance, processing flowability are good.
To achieve the above object of the invention, the technical solution adopted by the present invention is that, a kind of haemodialysis extracorporeal circulation pipeline is used
The preparation method of material, includes the following steps:
I by (4Z) -4- [(E) -3- [3- carboxyl -5- oxo -1- (2,2,2- trifluoroethyl) -2H- pyrazoles -4- base] propyl- 2-
Alkene subunit] -5- oxo -1- (2,2,2- trifluoroethyl) pyrazoles -3- carboxylic acid, ethylene -1,1,2,2- tetrabasic carboxylic acid tetrasodium salt, 1,2,2-
Trifluoro vinyl tri-phenyl-silane, initiator, water, emulsifier, which are added in high boiling solvent, forms lotion, then in nitrogen or lazy
It being stirred to react 10-12 hours at 70-80 DEG C in property atmosphere, solvent is evaporated off in back spin, with ethanol washing product 3-5 times, after
It is placed at 70-80 DEG C of vacuum oven and dries to constant weight, obtain addition polymers；
II be added into the three-necked flask with agitating device polyurethane Jing Guo vacuum dehydration, acrylic acid -2- hydroxyl ethyl ester,
Catalyst and polymerization inhibitor are added in dimethyl sulfoxide, are stirred to react 10-12 hours under 85-95 DEG C of nitrogen atmosphere, after reaction
Cool to room temperature, after settle out in ethanol, and washed 3-5 times with ether, back spin is evaporated off ether and obtains vinyl modified polyurethane；
III be prepared by the addition polymers being prepared by step I, by step II vinyl modified polyurethane, idol
The different heptonitrile of nitrogen two, which is added to be uniformly mixed in high-speed mixer, forms mixture, then adds mixture into double screw extruder
Extrusion molding obtains haemodialysis extracorporeal circulation pipeline material.
Preferably, (4Z) -4- described in step I [(E) -3- [3- carboxyl -5- oxo -1- (2,2,2- trifluoroethyl) -2H-
Pyrazoles -4- base] propyl- 2- alkene subunit] -5- oxo -1- (2,2,2- trifluoroethyl) pyrazoles -3- carboxylic acid, ethylene -1,1,2,2- tetracarboxylic acid
Sour tetrasodium salt, 1,2,2- trifluoro vinyl tri-phenyl-silane, initiator, water, emulsifier, high boiling solvent mass ratio be 1:1:
1:(0.02-0.04):(5-8):(0.03-0.05):(3-5)。
Preferably, the initiator is selected from potassium peroxydisulfate, dibenzoyl peroxide, to isopropyl benzene hydroperoxide, azo two
One or more of isobutyronitrile.
Preferably, the high boiling solvent is in dimethyl sulfoxide, N-Methyl pyrrolidone, n,N-Dimethylformamide
It is one or more of.
Preferably, the inert gas is selected from one of helium, neon, argon gas.
Preferably, the emulsifier is selected from tributyl phenol polyoxyethylene ether, cumenyl phenol polyethenoxy ether formaldehyde condensation
One or more of object, ethoxylated dodecyl alcohol, polyoxylethylene abietate.
Preferably, polyurethane described in step II, acrylic acid -2- hydroxyl ethyl ester, the matter of catalyst, polymerization inhibitor, dimethyl sulfoxide
Amount is than being (3-5): 0.2:(0.05-0.1): 0.01:(10-15).
Preferably, the catalyst is selected from dibutyltin dilaurate, stannous octoate, triethylamine, ethylene diamine, three
One or more of ethanol amine, triethylenediamine.
Preferably, the polymerization inhibitor is selected from tetrachloroquinone, l, at least one of 4- naphthoquinones.
Preferably, addition polymers described in step III, vinyl modified polyurethane, azobisisoheptonitrile mass ratio be 1:2:
(0.02-0.04)。
Preferably, the speed of mainshaft of the high-speed mixer is 1000-1200rpm.
Preferably, the technological parameter of the extrusion molding are as follows: heating temperature is 210-220 DEG C, and head extrusion temperature is
230-250 DEG C, extruder driving screw revolving speed 130-140r/min, feed revolving speed 160-180r/min.
A kind of haemodialysis extracorporeal circulation pipeline material, using the system of above-mentioned haemodialysis extracorporeal circulation pipeline material
Preparation Method is prepared.
The beneficial effects of adopting the technical scheme are that
1) haemodialysis extracorporeal circulation pipeline material provided by the invention, preparation method is simple, and preparation cost is low
It is honest and clean, be more suitable for it is practical, and with the utility value in industry.
2) haemodialysis extracorporeal circulation pipeline material provided by the invention has good biocompatibility, not teratogenesis
It is carcinogenic, it does not cause allergic reaction；Excellent blood compatibility, hemolytic are low, and anticoagulant property is good, and resist chemical, wear-resisting, machine
Tool excellent in mechanical performance, processing flowability are good.
3) haemodialysis extracorporeal circulation pipeline material provided by the invention, main chain use (4Z) -4- [(E) -3- [3- carboxylic
Base -5- oxo -1- (2,2,2- trifluoroethyl) -2H- pyrazoles -4- base] propyl- 2- alkene subunit] -5- oxo -1- (2,2,2- trifluoro second
Base) pyrazoles -3- carboxylic acid, ethylene -1,1,2,2- tetrabasic carboxylic acid tetrasodium salts, the copolymerization of 1,2,2- trifluoro vinyl tri-phenyl-silanes have
Hydrophobe both sexes feature, to reducing, blood clotting, thrombus side effect effect are good, have apparent facilitation to hemodialysis quality is improved, together
Shi Hanyou fluorine silicon structure, so that material has excellent weatherability, mechanical mechanics property and wearability；Contain on strand after copolymerization
There is unsaturated bond, in formative stage, polyurethane reaction with vinyl modified forms three-dimensional net structure, further improves
The comprehensive performance of material, and polyurethane structural is introduced, so that the biocompatibility of material enhances, anticoagulation ability is more preferably.
Specific embodiment
In order to make those skilled in the art more fully understand technical solution of the present invention, and make features described above of the invention,
Purpose and advantage are more clear understandable, and the present invention will be further explained with reference to the examples below.Embodiment is only used for
It is bright the present invention rather than limit the scope of the invention.
Embodiment 1
A kind of preparation method of haemodialysis extracorporeal circulation pipeline material, includes the following steps:
I by (4Z) -4- [(E) -3- [3- carboxyl -5- oxo -1- (2,2,2- trifluoroethyl) -2H- pyrazoles -4- base] propyl- 2-
Alkene subunit] -5- oxo -1- (2,2,2- trifluoroethyl) pyrazoles -3- carboxylic acid 1kg, ethylene -1,1,2,2- tetrabasic carboxylic acid tetrasodium salt 1kg,
1,2,2- trifluoro vinyl tri-phenyl-silane 1kg, potassium peroxydisulfate 0.02kg, water 5kg, tributyl phenol polyoxyethylene ether 0.03kg add
Entering into dimethyl sulfoxide 3kg and form lotion, then is stirred to react at 70 DEG C 10 hours in nitrogen atmosphere, solvent is evaporated off in back spin,
With ethanol washing product 3 times, it is placed at 70 DEG C of vacuum oven and dries to constant weight, obtain addition polymers；
II polyurethane 3kg Jing Guo vacuum dehydration, acrylic acid -2- hydroxyl second are added into the three-necked flask with agitating device
Ester 0.2kg, dibutyltin dilaurate 0.05kg and tetrachloroquinone 0.01kg are added in dimethyl sulfoxide 10kg, in 85 DEG C of nitrogen
Be stirred to react under atmosphere 10 hours, cool to room temperature after reaction, after settle out in ethanol, and washed 3 times with ether, it is rear to rotate
It removes ether and obtains vinyl modified polyurethane；
III will pass through the addition polymers 1kg that step I is prepared, the vinyl modified polyurethane being prepared by step II
2kg, azobisisoheptonitrile 0.02kg, which are added to be uniformly mixed in high-speed mixer, forms mixture, then adds mixture into double
Extrusion molding in screw extruder obtains haemodialysis extracorporeal circulation pipeline material；The speed of mainshaft of the high-speed mixer
For 1000rpm；The technological parameter of the extrusion molding are as follows: heating temperature is 210 DEG C, and head extrusion temperature is 230 DEG C, extruder
Driving screw revolving speed 130r/min, feed revolving speed 160r/min.
A kind of haemodialysis extracorporeal circulation pipeline material, using the system of above-mentioned haemodialysis extracorporeal circulation pipeline material
Preparation Method is prepared.
Embodiment 2
A kind of preparation method of haemodialysis extracorporeal circulation pipeline material, includes the following steps:
I by (4Z) -4- [(E) -3- [3- carboxyl -5- oxo -1- (2,2,2- trifluoroethyl) -2H- pyrazoles -4- base] propyl- 2-
Alkene subunit] -5- oxo -1- (2,2,2- trifluoroethyl) pyrazoles -3- carboxylic acid 1kg, ethylene -1,1,2,2- tetrabasic carboxylic acid tetrasodium salt 1kg,
1,2,2- trifluoro vinyl tri-phenyl-silane 1kg, dibenzoyl peroxide 0.025kg, water 6kg, cumenyl phenol polyethenoxy
Ether formaldehyde condensation products 0.035kg, which is added in N-Methyl pyrrolidone 3.5kg, forms lotion, then stirs at 72 DEG C in helium atmosphere
Reaction 10.5 hours is mixed, solvent is evaporated off in back spin, with ethanol washing product 4 times, is placed at 73 DEG C of vacuum oven and dries extremely
Constant weight obtains addition polymers；
II polyurethane 3.5kg, acrylic acid -2- hydroxyl Jing Guo vacuum dehydration are added into the three-necked flask with agitating device
Ethyl ester 0.2kg, stannous octoate 0.06kg and l, 4- naphthoquinones 0.01kg are added in dimethyl sulfoxide 12kg, stir under 88 DEG C of nitrogen atmospheres
Mix reaction 10.5 hours, cool to room temperature after reaction, after settle out in ethanol, and washed 4 times with ether, second is evaporated off in back spin
Ether obtains vinyl modified polyurethane；
III will pass through the addition polymers 1kg that step I is prepared, the vinyl modified polyurethane being prepared by step II
2kg, azobisisoheptonitrile 0.025kg, which are added to be uniformly mixed in high-speed mixer, forms mixture, then adds mixture into
Extrusion molding in double screw extruder obtains haemodialysis extracorporeal circulation pipeline material；The main shaft of the high-speed mixer turns
Speed is 1050rpm；The technological parameter of the extrusion molding are as follows: heating temperature is 212 DEG C, and head extrusion temperature is 235 DEG C, is squeezed out
Owner screw speed 132r/min, feed revolving speed 165r/min.
A kind of haemodialysis extracorporeal circulation pipeline material, using the system of above-mentioned haemodialysis extracorporeal circulation pipeline material
Preparation Method is prepared.
Embodiment 3
A kind of preparation method of haemodialysis extracorporeal circulation pipeline material, includes the following steps:
I by (4Z) -4- [(E) -3- [3- carboxyl -5- oxo -1- (2,2,2- trifluoroethyl) -2H- pyrazoles -4- base] propyl- 2-
Alkene subunit] -5- oxo -1- (2,2,2- trifluoroethyl) pyrazoles -3- carboxylic acid 1kg, ethylene -1,1,2,2- tetrabasic carboxylic acid tetrasodium salt 1kg,
1,2,2- trifluoro vinyl tri-phenyl-silane 1kg, to isopropyl benzene hydroperoxide 0.03kg, water 6.5kg, ethoxylated dodecyl alcohol
0.04kg, which is added in n,N-Dimethylformamide 4kg, forms lotion, then is stirred to react at 75 DEG C 11 hours in neon atmosphere,
Solvent is evaporated off in back spin, with ethanol washing product 5 times, is placed at 76 DEG C of vacuum oven and dries to constant weight, obtain addition polymers；
II polyurethane 4kg Jing Guo vacuum dehydration, acrylic acid -2- hydroxyl second are added into the three-necked flask with agitating device
Ester 0.2kg, triethylamine 0.08kg and tetrachloroquinone 0.01kg are added in dimethyl sulfoxide 13kg, stir under 90 DEG C of nitrogen atmospheres anti-
Answer 11 hours, cool to room temperature after reaction, after settle out in ethanol, and washed 5 times with ether, back spin is evaporated off ether and obtains
Vinyl modified polyurethane；
III will pass through the addition polymers 1kg that step I is prepared, the vinyl modified polyurethane being prepared by step II
2kg, azobisisoheptonitrile 0.03kg, which are added to be uniformly mixed in high-speed mixer, forms mixture, then adds mixture into double
Extrusion molding in screw extruder obtains haemodialysis extracorporeal circulation pipeline material；The speed of mainshaft of the high-speed mixer
For 1100rpm；The technological parameter of the extrusion molding are as follows: heating temperature is 216 DEG C, and head extrusion temperature is 240 DEG C, extruder
Driving screw revolving speed 136r/min, feed revolving speed 170r/min.
A kind of haemodialysis extracorporeal circulation pipeline material, using the system of above-mentioned haemodialysis extracorporeal circulation pipeline material
Preparation Method is prepared.
Embodiment 4
A kind of preparation method of haemodialysis extracorporeal circulation pipeline material, includes the following steps:
I by (4Z) -4- [(E) -3- [3- carboxyl -5- oxo -1- (2,2,2- trifluoroethyl) -2H- pyrazoles -4- base] propyl- 2-
Alkene subunit] -5- oxo -1- (2,2,2- trifluoroethyl) pyrazoles -3- carboxylic acid 1kg, ethylene -1,1,2,2- tetrabasic carboxylic acid tetrasodium salt 1kg,
1,2,2- trifluoro vinyl tri-phenyl-silane 1kg, initiator 0.035kg, water 7kg, that emulsifier 0.045kg is added to higher boiling is molten
Lotion is formed in agent 4.5kg, then is stirred to react at 78 DEG C 11.5 hours in argon atmosphere, and solvent is evaporated off in back spin, uses ethyl alcohol
It washed product 4 times, is placed at 78 DEG C of vacuum oven and dries to constant weight, obtain addition polymers；The initiator be potassium peroxydisulfate,
Dibenzoyl peroxide, the mixture that isopropyl benzene hydroperoxide, azodiisobutyronitrile 1:2:1:2 in mass ratio are mixed；
The high boiling solvent is that dimethyl sulfoxide, N-Methyl pyrrolidone, N,N-dimethylformamide 2:3:1 in mass ratio are mixed
Mixture；The emulsifier is tributyl phenol polyoxyethylene ether, cumenyl phenol polyethenoxy ether formaldehyde condensation products, laruyl alcohol
The mixture that polyoxyethylene ether, polyoxylethylene abietate 1:1:2:1 in mass ratio are mixed；
II polyurethane 4.5kg, acrylic acid -2- hydroxyl Jing Guo vacuum dehydration are added into the three-necked flask with agitating device
Ethyl ester 0.2kg, catalyst 0.09kg and polymerization inhibitor 0.01kg are added in dimethyl sulfoxide 14kg, stir under 93 DEG C of nitrogen atmospheres anti-
Answer 11.5 hours, cool to room temperature after reaction, after settle out in ethanol, and washed 5 times with ether, back spin is evaporated off ether and obtains
To vinyl modified polyurethane；The catalyst is dibutyltin dilaurate, stannous octoate, ethylene diamine, three ethyl alcohol
The mixture that amine 2:3:4:1 in mass ratio is mixed；The polymerization inhibitor is tetrachloroquinone, l, and 4- naphthoquinones 3:5 in mass ratio is mixed
Mixture made of conjunction；
III will pass through the addition polymers 1kg that step I is prepared, the vinyl modified polyurethane being prepared by step II
2kg, azobisisoheptonitrile 0.035kg, which are added to be uniformly mixed in high-speed mixer, forms mixture, then adds mixture into
Extrusion molding in double screw extruder obtains haemodialysis extracorporeal circulation pipeline material；The main shaft of the high-speed mixer turns
Speed is 1150rpm；The technological parameter of the extrusion molding are as follows: heating temperature is 218 DEG C, and head extrusion temperature is 245 DEG C, is squeezed out
Owner screw speed 138r/min, feed revolving speed 175r/min.
A kind of haemodialysis extracorporeal circulation pipeline material, using the system of above-mentioned haemodialysis extracorporeal circulation pipeline material
Preparation Method is prepared.
Embodiment 5
A kind of preparation method of haemodialysis extracorporeal circulation pipeline material, includes the following steps:
I by (4Z) -4- [(E) -3- [3- carboxyl -5- oxo -1- (2,2,2- trifluoroethyl) -2H- pyrazoles -4- base] propyl- 2-
Alkene subunit] -5- oxo -1- (2,2,2- trifluoroethyl) pyrazoles -3- carboxylic acid 1kg, ethylene -1,1,2,2- tetrabasic carboxylic acid tetrasodium salt 1kg,
1,2,2- trifluoro vinyl tri-phenyl-silane 1kg, azodiisobutyronitrile 0.04kg, water 8kg, polyoxylethylene abietate 0.05kg
It is added in N-Methyl pyrrolidone 5kg and forms lotion, then be stirred to react at 80 DEG C 12 hours in nitrogen atmosphere, back spin is evaporated off
Solvent is removed, with ethanol washing product 5 times, is placed at 80 DEG C of vacuum oven and dries to constant weight, obtain addition polymers；
II polyurethane 5kg Jing Guo vacuum dehydration, acrylic acid -2- hydroxyl second are added into the three-necked flask with agitating device
Ester 0.2kg, triethylenediamine 0.1kg and l, 4- naphthoquinones 0.01kg is added in dimethyl sulfoxide 15kg, under 95 DEG C of nitrogen atmospheres
Be stirred to react 12 hours, cool to room temperature after reaction, after settle out in ethanol, and washed 5 times with ether, second is evaporated off in back spin
Ether obtains vinyl modified polyurethane；
III will pass through the addition polymers 1kg that step I is prepared, the vinyl modified polyurethane being prepared by step II
2kg, azobisisoheptonitrile 0.04kg, which are added to be uniformly mixed in high-speed mixer, forms mixture, then adds mixture into double
Extrusion molding in screw extruder obtains haemodialysis extracorporeal circulation pipeline material；The speed of mainshaft of the high-speed mixer
For 1200rpm；The technological parameter of the extrusion molding are as follows: heating temperature is 220 DEG C, and head extrusion temperature is 250 DEG C, extruder
Driving screw revolving speed 140r/min, feed revolving speed 180r/min.
A kind of haemodialysis extracorporeal circulation pipeline material, using the system of above-mentioned haemodialysis extracorporeal circulation pipeline material
Preparation Method is prepared.
Comparative example
This example provides a kind of for hemodialysis pipeline modified PVC pellet, formula and the same Chinese invention of preparation method
Patent CN 105061928A embodiment 1.
Haemodialysis extracorporeal circulation pipeline prepared by above embodiments 1-5 is used for hemodialysis tube with material and comparative example
Road is tested for the property with modified PVC pellet, and test result and test method are shown in Table 1.
As seen from Table 1, haemodialysis extracorporeal circulation pipeline material disclosed by the embodiments of the present invention, with blood in the prior art
Liquid dialysis extracorporeal circulation pipeline is compared with material, has more excellent mechanical mechanics property, biocompatibility and hemolytic.
Table 1
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and what is described in the above embodiment and the description is only the present invention
Principle, various changes and improvements may be made to the invention without departing from the spirit and scope of the present invention, these variation and
Improvement is both fallen in the range of claimed invention.The present invention claims protection scope by appended claims and its
Equivalent defines.
Claims (10)
1. a kind of preparation method of haemodialysis extracorporeal circulation pipeline material, which comprises the steps of:
I by (4Z) -4-, [(E) -3- [3- carboxyl -5- oxo -1- (2,2,2- trifluoroethyl) -2H- pyrazoles -4- base] propyl- 2- alkene is sub-
Base] -5- oxo -1- (2,2,2- trifluoroethyl) pyrazoles -3- carboxylic acid, ethylene -1,1,2,2- tetrabasic carboxylic acid tetrasodium salt, 1,2,2- trifluoro
Vinyl tri-phenyl-silane, initiator, water, emulsifier, which are added in high boiling solvent, forms lotion, then in nitrogen or indifferent gas
It is stirred to react at 70-80 DEG C 10-12 hours in body atmosphere, solvent is evaporated off in back spin, with ethanol washing product 3-5 times, is placed on
It dries at 70-80 DEG C of vacuum oven to constant weight, obtains addition polymers；
II polyurethane Jing Guo vacuum dehydration is added into the three-necked flask with agitating device, acrylic acid -2- hydroxyl ethyl ester, is catalyzed
Agent and polymerization inhibitor are added in dimethyl sulfoxide, are stirred to react under 85-95 DEG C of nitrogen atmosphere 10-12 hours, cool down after reaction
To room temperature, after settle out in ethanol, and washed 3-5 times with ether, back spin is evaporated off ether and obtains vinyl modified polyurethane；
III will pass through the addition polymers that step I is prepared, the vinyl modified polyurethane, the azo two that are prepared by step II
Different heptonitrile, which is added to be uniformly mixed in high-speed mixer, forms mixture, then adds mixture into double screw extruder and squeeze out
Molding, obtains haemodialysis extracorporeal circulation pipeline material.
2. the preparation method of haemodialysis extracorporeal circulation pipeline material according to claim 1, which is characterized in that step
(4Z) -4- described in I [(E) -3- [3- carboxyl -5- oxo -1- (2,2,2- trifluoroethyl) -2H- pyrazoles -4- base] propyl- 2- alkene is sub-
Base] -5- oxo -1- (2,2,2- trifluoroethyl) pyrazoles -3- carboxylic acid, ethylene -1,1,2,2- tetrabasic carboxylic acid tetrasodium salt, 1,2,2- trifluoro
Vinyl tri-phenyl-silane, initiator, water, emulsifier, high boiling solvent mass ratio be 1:1:1:(0.02-0.04): (5-
8):(0.03-0.05):(3-5)。
3. the preparation method of haemodialysis extracorporeal circulation pipeline material according to claim 1, which is characterized in that described
Initiator is selected from potassium peroxydisulfate, dibenzoyl peroxide, to one of isopropyl benzene hydroperoxide, azodiisobutyronitrile or several
Kind.
4. the preparation method of haemodialysis extracorporeal circulation pipeline material according to claim 1, which is characterized in that described
High boiling solvent is selected from one or more of dimethyl sulfoxide, N-Methyl pyrrolidone, N,N-dimethylformamide；The inertia
Gas is selected from one of helium, neon, argon gas.
5. the preparation method of haemodialysis extracorporeal circulation pipeline material according to claim 1, which is characterized in that described
Emulsifier be selected from tributyl phenol polyoxyethylene ether, cumenyl phenol polyethenoxy ether formaldehyde condensation products, ethoxylated dodecyl alcohol,
One or more of polyoxylethylene abietate.
6. the preparation method of haemodialysis extracorporeal circulation pipeline material according to claim 1, which is characterized in that step
Polyurethane described in II, acrylic acid -2- hydroxyl ethyl ester, catalyst, polymerization inhibitor, dimethyl sulfoxide mass ratio be (3-5): 0.2:
(0.05-0.1):0.01:(10-15)。
7. the preparation method of haemodialysis extracorporeal circulation pipeline material according to claim 1, which is characterized in that described
Catalyst is selected from dibutyltin dilaurate, stannous octoate, triethylamine, ethylene diamine, triethanolamine, triethylenediamine
One or more of；The polymerization inhibitor is selected from tetrachloroquinone, l, at least one of 4- naphthoquinones.
8. the preparation method of haemodialysis extracorporeal circulation pipeline material according to claim 1, which is characterized in that step
Addition polymers described in III, vinyl modified polyurethane, azobisisoheptonitrile mass ratio be 1:2:(0.02-0.04).
9. the preparation method of haemodialysis extracorporeal circulation pipeline material according to claim 1, which is characterized in that described
The speed of mainshaft of high-speed mixer is 1000-1200rpm；The technological parameter of the extrusion molding are as follows: heating temperature 210-220
DEG C, head extrusion temperature is 230-250 DEG C, extruder driving screw revolving speed 130-140r/min, and feed revolving speed 160-180r/min.
10. prepared by a kind of preparation method using any one of the claim 1-9 haemodialysis extracorporeal circulation pipeline material
Made of haemodialysis extracorporeal circulation pipeline material.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113633840A (en) * | 2020-05-11 | 2021-11-12 | 苏州佳世达电通有限公司 | Hemodialyzer and hemodialysis system using same |
-
2018
- 2018-10-26 CN CN201811259364.6A patent/CN109486209A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113633840A (en) * | 2020-05-11 | 2021-11-12 | 苏州佳世达电通有限公司 | Hemodialyzer and hemodialysis system using same |
| CN113633840B (en) * | 2020-05-11 | 2024-05-17 | 苏州佳世达电通有限公司 | Hemodialysis ware and use its hemodialysis system |
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