CN109481593A - A kind of drug and preparation method thereof for treating uremia, kidney failure - Google Patents

A kind of drug and preparation method thereof for treating uremia, kidney failure Download PDF

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CN109481593A
CN109481593A CN201811637811.7A CN201811637811A CN109481593A CN 109481593 A CN109481593 A CN 109481593A CN 201811637811 A CN201811637811 A CN 201811637811A CN 109481593 A CN109481593 A CN 109481593A
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parts
radix
drug
kidney failure
water
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黄书德
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533—Leonurus (motherwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/86—Violaceae (Violet family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention discloses a kind of drugs and preparation method thereof for treating uremia, kidney failure, by weight, including following raw material: 14-16 parts of monkshood, 14-16 parts of Rhizoma Atractylodis Macrocephalae, 14-16 parts of radix pseudostellariae, 8-12 parts of Radix Astragali, 8-12 parts of Radix Salviae Miltiorrhizae, 8-12 parts of motherwort, 8-12 parts of radix achyranthis bidentatae, 8-12 parts of Chinese violet, 8-12 parts of rhizoma imperatae, 10-14 parts of Cortex Eucommiae, 18-22 parts of rheum officinale, 10-14 parts of camphortree root, 8-10 parts of Chen Ai, 10-14 parts of brown sugar.The effect of present invention plays blood-nourishing production of sperm by the synergistic effect of each drug, kidney tonifying void is lost, clearing heat and detoxicating, stranguria treating and diuresis inducing.Treatment uremia, kidney failure have the characteristics that rapid-action, good effect, safe without toxic side effect.Clinical 120 patients use, total effective rate 97.5%.

Description

A kind of drug and preparation method thereof for treating uremia, kidney failure
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of drug for treating uremia, kidney failure also relates to this and controls Treat the preparation method of the drug of uremia, kidney failure.
Background technique
Chronic renal failure refers to that various kidney troubles lead to the gradual irreversibility decline of renal function, until function loses institute Clinical syndrome composed by a series of symptoms of appearance and metabolic disorder, abbreviation chronic kidney hypofunction.The terminal phase of chronic kidney hypofunction is For it has often been said that uremia.A uremia not instead of independent disease, the clinic that the kidney trouble in various advanced stages is shared are comprehensive Simulator sickness is that chronic renal failure enters syndrome composed by a series of clinical manifestations occurred when the terminal stage.Clinic is pressed Chronic kidney disease was divided into for 5 phases by the variation according to glomerular filtration rate, wherein 2~5 phases were the different phase of chronic renal failure progress, 5th phase was end stage renal failure, and be otherwise known as uremia.In uremic phase, in addition to water and metabolic disturbance of electrolyte and soda acid Outside dysequilibrium, due to toxic metabolite in vivo a large amount of retentions and alimentary canal, the heart, lung, nerve, muscle, skin, blood is presented The extensive systemic toxicity profiles symptom such as liquid.
Currently, uremic patient, frequently with low protein diet, decompression picks up anti-agent, oral adsorbent agent, calcium using calcium ion The conservative approach such as agent, vitamin, chalybeate and folic acid alleviate symptoms of uremia, but ineffective；And Western medicine Metoclopramide Tablets, Metoclopramide dihydrochloride for injection, green spit of fland promise, glutathione for injection etc., not only effect is not significant, and there are also serious Toxic side effect, the state of an illness is easy repeatedly, palliative, increases patient suffering, and long-term use can also generate many complication, thus Patient body function is damaged.Though dialysis treatment can alleviate the illnesss such as uremia, renal failure, extend patient to a certain extent Service life, but dialyse it is at high cost, patient suffering is big, and can not eradicate, and general patient and family can not receive dialysis treatment for a long time.
Chinese medicine treatment adverse reaction is small, and used Chinese medicine is also many kinds of currently on the market, but effect is irregular, I is unequal to ideal.
Summary of the invention
The purpose of the present invention is to provide a kind of rapid-action, good effect, the treatment uremia having no toxic side effect, kidney failures Drug.
Another object of the present invention is to provide the preparation methods of the drug of the treatment uremia, kidney failure.
A kind of drug for treating uremia, kidney failure of the invention, by weight, including following raw material:
14-16 parts of monkshood, 14-16 parts of Rhizoma Atractylodis Macrocephalae, 14-16 parts of radix pseudostellariae, 8-12 parts of Radix Astragali, 8-12 parts of Radix Salviae Miltiorrhizae, 8-12 parts of motherwort, 8-12 parts of radix achyranthis bidentatae, 8-12 parts of Chinese violet, 8-12 parts of rhizoma imperatae, 10-14 parts of Cortex Eucommiae, 18-22 parts of rheum officinale, 10-14 parts of camphortree root, Chen Ai 8-10 parts, 10-14 parts of brown sugar.
A kind of above-mentioned drug for treating uremia, kidney failure, by weight, preferably following raw material:
15 parts of monkshood, 15 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of radix pseudostellariae, 10 parts of Radix Astragali, 10 parts of Radix Salviae Miltiorrhizae, 10 parts of motherwort, 10 parts of radix achyranthis bidentatae, Chinese violet 10 Part, 10 parts of rhizoma imperatae, 12 parts of Cortex Eucommiae, 20 parts of rheum officinale, 12 parts of camphortree root, 9 parts of Chen Ai, 12 parts of brown sugar.
A kind of preparation method of above-mentioned drug for treating uremia, kidney failure, comprising the following steps:
(1) bulk pharmaceutical chemicals are screened, are sampled by weight；
(2) after adding 550-650 parts of water to boil by intense fire bulk pharmaceutical chemicals, 10-20min is continued boiling by slow fire, decocting liquid of fetching water；By the dregs of a decoction plus 350-450 parts of water after boiling by intense fire, continue boiling by slow fire 14-16min water intaking decocting liquid；The dregs of a decoction are added into 350-450 parts of water again, it is military After fire boils, 14-16min water intaking decocting liquid is continued boiling by slow fire；Merge decocting liquid three times, mix to obtain the final product.
Compared with prior art, the present invention there is obvious beneficial effect, as can be known from the above technical solutions: monkshood of the present invention, Rhizoma Atractylodis Macrocephalae, radix pseudostellariae, Radix Astragali, Radix Salviae Miltiorrhizae, motherwort, radix achyranthis bidentatae, Chinese violet, rhizoma imperatae, Cortex Eucommiae, rheum officinale, camphortree root, Chen Ai, brown sugar are original Material.Blood-nourishing production of sperm is played by the synergistic effect of each drug, the effect of kidney tonifying void is lost, clearing heat and detoxicating, stranguria treating and diuresis inducing.Of the invention Drug therapy uremia, kidney failure have the characteristics that rapid-action, good effect, safe without toxic side effect.Clinical 120 patients make With total effective rate 97.5%.
Specific embodiment
The beneficial effect of the present invention will be further illustrated by the following test examples the drug.
Test example: the clinical observation of drug of the present invention
1, clinical data:
All cases 120, in which: one full year of life at age 30-50, male 62, female 58.
2, diagnostic criteria:
" disease of tcm Standardization of diagnosis and curative effect ".
3, treatment method:
Drug obtained by the oral embodiment of the present invention, three times a day, each 150ml a, auxiliary takes two days, takes two pairs.
4, criterion of therapeutical effect:
Effective: symptom disappears；
Effective: symptom is relieved；
Invalid: symptom is not improved.
5, treatment results:
120 patients' use drugs of the present invention, effective 114, effective 3, invalid 3, obvious effective rate 95%, total effective rate 97.5%。
The preparation method of this drug is illustrated by following embodiment.
Embodiment 1
A kind of preparation method for treating uremic drug, comprising the following steps:
A kind of preparation method of drug that treating uremia, kidney failure, comprising the following steps:
(1) bulk pharmaceutical chemicals are screened, monkshood 14g, Rhizoma Atractylodis Macrocephalae 16g, radix pseudostellariae 14g, Radix Astragali 12g, Radix Salviae Miltiorrhizae 8g, motherwort 12g, radix achyranthis bidentatae are weighed 8g, Chinese violet 12g, rhizoma imperatae 8g, Cortex Eucommiae 14g, rheum officinale 18g, camphortree root 14g, Chen Ai 8g, brown sugar 14g；
(2) after adding 550g water to boil by intense fire bulk pharmaceutical chemicals, 20min water intaking decocting liquid is continued boiling by slow fire；It is military by the dregs of a decoction plus 350g water After fire boils, 16min water intaking decocting liquid is continued boiling by slow fire；Add 350g water, after boiling by intense fire, continue boiling by slow fire the dregs of a decoction again 16min water intaking decocting liquid；Merge decocting liquid three times, mix to obtain the final product.
Embodiment 2
A kind of preparation method of drug that treating uremia, kidney failure, comprising the following steps:
(1) bulk pharmaceutical chemicals are screened, monkshood 15g, Rhizoma Atractylodis Macrocephalae 15g, radix pseudostellariae 15g, Radix Astragali 10g, Radix Salviae Miltiorrhizae 10g, motherwort 10g, ox are weighed Knee 10g, Chinese violet 10g, rhizoma imperatae 10g, Cortex Eucommiae 12g, rheum officinale 20g, camphortree root 12g, Chen Ai 9g, brown sugar 12g；
(2) after adding 600g water to boil by intense fire bulk pharmaceutical chemicals, 15min water intaking decocting liquid is continued boiling by slow fire；It is military by the dregs of a decoction plus 400g water After fire boils, 15min water intaking decocting liquid is continued boiling by slow fire；Add 400g water, after boiling by intense fire, continue boiling by slow fire the dregs of a decoction again 15min water intaking decocting liquid；Merge decocting liquid three times, mix to obtain the final product.
Embodiment 3
A kind of preparation method of drug that treating uremia, kidney failure, comprising the following steps:
(1) bulk pharmaceutical chemicals are screened, monkshood 16g, Rhizoma Atractylodis Macrocephalae 14g, radix pseudostellariae 16g, Radix Astragali 8g, Radix Salviae Miltiorrhizae 12g, motherwort 8g, radix achyranthis bidentatae are weighed 12g, Chinese violet 8g, rhizoma imperatae 12g, Cortex Eucommiae 10g, rheum officinale 22g, camphortree root 10g, Chen Ai 10g, brown sugar 10g；
(2) after adding 650g water to boil by intense fire bulk pharmaceutical chemicals, 10min water intaking decocting liquid is continued boiling by slow fire；It is military by the dregs of a decoction plus 450g water After fire boils, 14min water intaking decocting liquid is continued boiling by slow fire；Add 450g water, after boiling by intense fire, continue boiling by slow fire the dregs of a decoction again 14min water intaking decocting liquid；Merge decocting liquid three times, mix to obtain the final product.
The above described is only a preferred embodiment of the present invention, being not intended to limit the present invention in any form, appoint What is to the above embodiments according to the technical essence of the invention any simply to repair without departing from technical solution of the present invention content Change, equivalent variations and modification, all of which are still within the scope of the technical scheme of the invention.

Claims (3)

1. a kind of drug for treating uremia, kidney failure, by weight, including following raw material:
14-16 parts of monkshood, 14-16 parts of Rhizoma Atractylodis Macrocephalae, 14-16 parts of radix pseudostellariae, 8-12 parts of Radix Astragali, 8-12 parts of Radix Salviae Miltiorrhizae, 8-12 parts of motherwort, 8-12 parts of radix achyranthis bidentatae, 8-12 parts of Chinese violet, 8-12 parts of rhizoma imperatae, 10-14 parts of Cortex Eucommiae, 18-22 parts of rheum officinale, 10-14 parts of camphortree root, Chen Ai 8-10 parts, 10-14 parts of brown sugar.
2. a kind of drug for treating uremia, kidney failure as described in claim 1, by weight, including following raw material:
15 parts of monkshood, 15 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of radix pseudostellariae, 10 parts of Radix Astragali, 10 parts of Radix Salviae Miltiorrhizae, 10 parts of motherwort, 10 parts of radix achyranthis bidentatae, Chinese violet 10 Part, 10 parts of rhizoma imperatae, 12 parts of Cortex Eucommiae, 20 parts of rheum officinale, 12 parts of camphortree root, 9 parts of Chen Ai, 12 parts of brown sugar.
3. a kind of preparation method for the drug for treating uremia, kidney failure as claimed in claim 1 or 2, comprising the following steps:
(1) bulk pharmaceutical chemicals are screened, are sampled by weight；
(2) after adding 550-650 parts of water to boil by intense fire bulk pharmaceutical chemicals, 10-20min is continued boiling by slow fire, decocting liquid of fetching water；By the dregs of a decoction plus 350-450 parts of water after boiling by intense fire, continue boiling by slow fire 14-16min water intaking decocting liquid；The dregs of a decoction are added into 350-450 parts of water again, it is military After fire boils, 14-16min water intaking decocting liquid is continued boiling by slow fire；Merge decocting liquid three times, mix to obtain the final product.
CN201811637811.7A 2018-12-29 2018-12-29 A kind of drug and preparation method thereof for treating uremia, kidney failure Pending CN109481593A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104623579A (en) * 2013-11-11 2015-05-20 李耀华 Traditional Chinese medicine composition for treating uremia
WO2016093613A2 (en) * 2014-12-10 2016-06-16 한국한의학연구원 Composition for preventing or treating abnormal weight loss, containing citrus unshiu peel extract

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104623579A (en) * 2013-11-11 2015-05-20 李耀华 Traditional Chinese medicine composition for treating uremia
WO2016093613A2 (en) * 2014-12-10 2016-06-16 한국한의학연구원 Composition for preventing or treating abnormal weight loss, containing citrus unshiu peel extract

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
华亦露，饶肖平: "温阳泄浊、活血化瘀法治疗毒症30例疗效观察", 《浙江中西医结合杂志》 *
巫斌等: "《健康调治妙法》", 31 May 2006, 羊城晚报出版社 *
张翔华: "慢性肾功能衰竭治验", 《上海中医药杂志》 *

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Application publication date: 20190319