CN109481004A - A kind of cold cold probe of ablating device electricity consumption of electricity - Google Patents
A kind of cold cold probe of ablating device electricity consumption of electricity Download PDFInfo
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- CN109481004A CN109481004A CN201811653552.7A CN201811653552A CN109481004A CN 109481004 A CN109481004 A CN 109481004A CN 201811653552 A CN201811653552 A CN 201811653552A CN 109481004 A CN109481004 A CN 109481004A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1477—Needle-like probes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0231—Characteristics of handpieces or probes
- A61B2018/0262—Characteristics of handpieces or probes using a circulating cryogenic fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0293—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument interstitially inserted into the body, e.g. needle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1467—Probes or electrodes therefor using more than two electrodes on a single probe
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Abstract
The present invention provides a kind of cold cold probe of ablating device electricity consumption of electricity, the cold probe of electricity includes the shell being made of cutter head and knife bar and is set to the intracorporal air inlet pipe of shell, and the cutter head shell is equipped at least two electrode, and the housing wall between electrode is insulation wall.Compared with the existing technology, at least two electrode connecting with the DC generator or electric pulse generator is equipped in the cold probe of electricity of the present invention, that is single probe realizes that cold ablation is melted with electricity simultaneously, reduces spininess and punctures, facilitates clinical use, enhancing therapeutic effect and shorten treatment time.
Description
Technical field
The invention belongs to technical field of medical equipment, more particularly, to the cold cold probe of ablating device electricity consumption of electricity.
Background technique
Cryosurgery treatment is to damage in method and human history with ablation lesion tissue to make earliest using ultralow temperature
Pathological tissues ablation techniques.From nineteen sixty American Psychiatry surgeon Irving Cooper and engineer Arnold Lee
Probe shape liquid nitrogen freezing apparatus is invented and for using liquid nitrogen as cryogenic fluid (refrigerant), heated nitrogen after freezing brain tissue
Liquid nitrogen frozen surgical device as high temperature refrigerant (heating agent) is applied to treat various tumours.From generation nineteen ninety, based on coke
The invention and application of ear-thomson principle gas throttling type cryogenic freezing surgery system, such as using high pressure argon gas freezing and helium
The argon helium knife of gas rewarming is widely used to the cryoablation treatment of various innocent and malignant tumours.
Due to will appear biggish variable density before and after tissue or organ, therefore the outstanding advantages of cold therapy are to pass through
The medical imaging procedures such as ultrasound relevant to density, CT and MRI, the image of display tissue freezing range.The group that scientific circles prove
Knitting the lethal temperature range of cryoablation is and to freeze the lowest temperature (usually less than -80 DEG C) of regional center certainly extremely lower than -40 DEG C
The lethal temperature range, much smaller than freezing region itself (typically less than half).That is -40 DEG C of freezing region extremely freezing side
A large amount of tissues in edge (0 DEG C) range are not melted effectively, still can be survived.The namely freezing that shows of medical image
Region and non-treatment boundary, especially in neighbouring big angiosomes.
A large amount of scientific researches also turn out simultaneously: reaching effective cryoablation to tumor tissues, it is necessary to using " cold twice
The circulation of jelly-rewarming ".And recycle every time, 20~30min is needed, the process of cryoablation takes a long time.Cryoablation technology is anxious
Need a kind of thoroughly ablation and time-consuming shorter improved method.
Electricity ablation is the ablation techniques based on DC electric field, AC field or impulse electric field, including electrolysis ablation, electroporation
Ablation etc..Electrolysis ablation is also referred to as electrochemotherapy (EChT) early in just having been used for micro-wound tissue ablation 19th century,
It is to melt probe by electricity of the root cutting in processing tissue DC current is transmitted in therapeutic domain, causes therapeutic domain local
PH value variation and form cytotoxin environment, and some new chemical substances for being formed in electrolytic process and then cause thin
The method of born of the same parents' death.Electrolysis ablation needs very low DC current (tens arrive several hundred milliamperes) and very low voltage (several to ten
Several volts).Therefore equipment is not only simple but also safe, this is its advantage place.But due to the length of time of this cell death method
It is the diffusion rate of electrochemical products as being generated in tissue and the concentration of electrolysate required for Apoptosis is caused to be determined
Fixed, therefore, the therapeutic process for being electrolysed ablation takes a long time, and from dozens of minutes to a few houres etc., this is also electrolysis ablation skill
The limitation of art.
Electroporation ablation is to make cell membrane permeabilization by applying very of short duration high-amplitude electric field pulse, causes cell by group
It knits liquid and poisons lethal, cell membrane the degree of transparency is the exercising result of electric field strength.Electroporation is divided into reversible electroporation and irreversible
Electroporation: reversible electroporation is available to make lipid bilayer generate reversible hole, to allow point of such as gene and drug
Son is introduced into cell.Irreversible electroporation principle is to act on to break up higher than 500~600V/cm electric pulse using electric field strength
Tumor cell membrane generates cell membrane a large amount of permanent nanometer level microporous, to destroy intracellular steady state, promotes Apoptosis,
Eventually lead to the thorough death of cell.It has the advantages that not heat production, does not generate damage to cavity, blood vessel and nerve etc.；Disadvantage
It is that ablation range is not visible and the incomplete problem of ablation.
Therefore, it is necessary to the ablations of a kind of new therapeutic device the advantages of merging above-mentioned tumour ablation and above-mentioned apparatus adaptation
Probe solves the problems, such as therapeutic device in the prior art or treatment method.
Summary of the invention
In view of this, the present invention is directed to propose a kind of cold cold probe of ablating device electricity consumption of electricity, can be adapted for merging cold disappear
Melt the device with electricity ablation, by the clear boundary of freezing formation and to the precipitation effect of electrolyte, in conjunction with electrolysis ablation to cold
The supplement for freezing boundary ablation had not only solved the problems, such as that freezing degree that image is shown and actual ablation range were inconsistent, but also
Shorten treatment time.
In order to achieve the above objectives, the technical scheme of the present invention is realized as follows: a kind of cold cold spy of ablating device electricity consumption of electricity
Needle, the cold probe of electricity are connect by connection component with host, and the cold probe of electricity includes the shell being made of cutter head and knife bar
Be set to the intracorporal air inlet pipe of shell, the cutter head shell is equipped at least two electrode, and mutually insulated between electrode.
The cold cold probe of ablating device electricity consumption of electricity of the invention can also be with flowering structure: the cold probe of electricity includes by cutter head
With knife bar composition shell and be set to the intracorporal air inlet pipe of shell, 1 electricity is respectively equipped on the cutter head shell and knife bar shell
Pole, and mutually insulated between electrode.
Further, be equipped with 2 electrodes in the cutter head, the cutter head be divided into puncture portion, the first active region, insulation layer and
Second active region, wherein the corresponding inner walls in first active region are equipped with first electrode, the second active region is corresponding
Inner walls are equipped with second electrode, and the first electrode and second electrode pass through electrode cable and connect with host, described exhausted
The corresponding housing wall in edge area is insulation wall.
Further, thermometric galvanic couple is equipped in the cutter head, thermometric galvanic couple is connect by temperature measuring wire with host.
Further, insulation is equipped on the partial shell inner wall at the knife bar other than the shell for being provided with electrode
Layer, electric insulation layer is equipped on outer wall.
Further, the cutter head and knife bar are integrally formed；The thermometric galvanic couple be set to the cutter head enclosure interior or
It is set to the outlet side of the air inlet pipe.
Further, a wherein temperature measuring wire for the thermometric galvanic couple and the electrode cable of the first electrode synthesize
One, the thermometric galvanic couple is used as first electrode simultaneously.
Further, the host includes controller, freeze melting device, further includes direct current hair connected to the controller
At least one of raw device, electric pulse generator.Preferably, the cold source in the freeze melting device is liquid nitrogen, nitrogen, argon
One of gas, nitric oxide or carbon dioxide.
Further, the electric pulse of the electric pulse generator transmitting 100V~3000V.
Further, an electrode logic is additionally provided between the DC generator and electric pulse generator and the cold probe of electricity
Distributor.
Compared with the existing technology, the cold cold probe of ablating device electricity consumption of electricity of the present invention has the advantage that
(1) electricity connecting with the DC generator or electric pulse generator is equipped in the cold probe of electricity of the present invention
Pole, suitable for merging the device of cold ablation with electricity ablation, and a knife is equipped at least 1 pair of electrode, for only needing the trouble of a knife
Diseased tissues can equally play the combined treatment effect of cryoablation and electricity ablation, good operation effect and treatment time is short；And electricity
Cold probe has the advantages that structure is simple and easy to implement；
(2) the cold ablating device of electricity in the present invention, by setting DC generator, electric pulse generator by cryoablation
It is combined together with electricity ablation, by the clear boundary of freezing formation and to the precipitation effect of electrolyte, in conjunction with electricity ablation to cold
The supplement for freezing boundary ablation had not only solved the problems, such as that freezing degree that image is shown and actual ablation range were inconsistent, but also
Shorten treatment time.
Detailed description of the invention
The attached drawing for constituting a part of the invention is used to provide further understanding of the present invention, schematic reality of the invention
It applies example and its explanation is used to explain the present invention, do not constitute improper limitations of the present invention.In the accompanying drawings:
Fig. 1 is a kind of structural schematic diagram of embodiment of the cold cold probe of ablating device electricity consumption of electricity of the present invention；
Fig. 2 is the structural schematic diagram of another embodiment of the cold cold probe of ablating device electricity consumption of electricity of the present invention；
Fig. 3 is the internal structure block diagram of the cold combination ablating device of electricity of the present invention.
Description of symbols:
In Fig. 1: 1- cutter head；11- puncture portion；The first active region 12-；13- insulation layer；The second active region 14-；2- knife bar；
3- electric insulation layer；4- heat insulation layer；5- thermometric galvanic couple；6- temperature measuring wire；7- air inlet pipe；81- first electrode；82- second electrode；9-
Electrode cable；
In Fig. 2: 1- cutter head；2- knife bar；3- electric insulation layer；4- heat insulation layer；7- air inlet pipe；8- electrode；9- electrode cable；
10- insulation wall.
Specific embodiment
It should be noted that in the absence of conflict, the feature in embodiment and embodiment in the present invention can phase
Mutually combination.
In the description of the present invention, it is to be understood that, term " center ", " longitudinal direction ", " transverse direction ", "upper", "lower",
The orientation or positional relationship of the instructions such as "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outside" is
It is based on the orientation or positional relationship shown in the drawings, is merely for convenience of description of the present invention and simplification of the description, rather than instruction or dark
Show that signified device or element must have a particular orientation, be constructed and operated in a specific orientation, therefore should not be understood as pair
Limitation of the invention.In addition, term " first ", " second " etc. are used for description purposes only, it is not understood to indicate or imply phase
To importance or implicitly indicate the quantity of indicated technical characteristic.The feature for defining " first ", " second " etc. as a result, can
To explicitly or implicitly include one or more of the features.In the description of the present invention, unless otherwise indicated, " multiple "
It is meant that two or more.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can
To be mechanical connection, it is also possible to be electrically connected；It can be directly connected, can also can be indirectly connected through an intermediary
Connection inside two elements.For the ordinary skill in the art, above-mentioned term can be understood by concrete condition
Concrete meaning in the present invention.
The present invention will be described in detail below with reference to the accompanying drawings and embodiments.
A kind of cold cold probe of ablating device electricity consumption of electricity, the cold probe of electricity are connect by connection component with host, the electricity
Cold probe includes the shell being made of cutter head 1 and knife bar 2 and is set to the intracorporal air inlet pipe 7 of shell, and the shell is equipped at least 2
A electrode 8 (including 81 and 82), and there is at least one electrode to be arranged on cutter head shell in above-mentioned electrode, remaining electrode can be set
Setting also can be set in the inner walls of knife bar on cutter head shell, but to avoid short circuit, need to meet electrode and electrode
Between a certain piece housing wall be insulation wall.If electrode is all set on cutter head shell, set in the inner walls at knife bar
There is heat insulation layer, housing exterior walls are equipped with electric insulation layer；If electrode is set on knife bar shell, in addition to being provided with electricity at knife bar
Heat insulation layer is equipped in the inner walls of remainder except the shell of pole, housing exterior walls are equipped with electric insulation layer.
Embodiment 1
As shown in Figure 1, as a preferred embodiment, being equipped with 2 electrodes in the cutter head 1, the cutter head 1 divides for puncture portion
11, the first active region 12, insulation layer 13 and the second active region 14, wherein in the corresponding inner walls in first active region 12
Equipped with first electrode 81, the corresponding inner walls in the second active region 14 are equipped with second electrode 82, the first electrode 81 and the
Two electrodes 82 are connect by electrode cable 9 with host, and the corresponding housing wall of the insulation layer 13 is insulation wall.Shell at knife bar
Internal wall is equipped with heat insulation layer 4, and housing exterior walls are equipped with electric insulation layer 3.Thermometric galvanic couple 5 is equipped in cutter head in the present embodiment,
Thermometric galvanic couple 5 is connect by temperature measuring wire 6 with host.And the cutter head 1 and knife bar 2 are integrally formed.As shown in figure 3, embodiment
In host include controller, freeze melting device, can also include that DC generator connected to the controller, electric pulse are sent out
At least one of raw device (preferred, the electric pulse of the electric pulse generator transmitting 100V~3000V).
In order to facilitate the operation of when, according to the current needs arbitrary switch DC generator and electric arteries and veins of electrode in the cold probe of electricity
The on-off relationship of generator and the probe that works is rushed, the DC generator and electric pulse generator and electricity in the present embodiment are cold
An electrode assignment of logical device can also be preferable provided between probe as needed.
In addition to this, as the preferred embodiment of the present embodiment, the thermometric galvanic couple can also be needed according to practical thermometric and
Manufacturing technique requirent is set to the enclosure interior of cutter head (puncture portion or the first active region) or is set to the outlet of the air inlet pipe
End.
Preferably, a wherein temperature measuring wire for the thermometric galvanic couple and the electrode cable of the first electrode close
As one, the thermometric galvanic couple is used as first electrode simultaneously.
Cold source in the freeze melting device is cryogenic liquids, nitrogen, argon gas, nitric oxide or the carbon dioxide such as liquid nitrogen
Deng one of throttling cooling gas.
Embodiment 2
The present embodiment is the electrode plan of establishment different from embodiment 1, as shown in Fig. 2, the cutter head in the present embodiment
1 electrode 8 is respectively equipped in inner walls and knife bar inner walls, and the housing wall between electrode is insulation wall 10；The knife
It is equipped with heat insulation layer 4 on partial shell inner wall at bar other than the shell for being provided with electrode, electrical isolation is equipped on outer wall
Layer 3.Not set thermometric galvanic couple in the present embodiment.
Electricity ablation in the present invention can be electrolysis ablation (when electrode connects DC generator) or electric pulse ablation (electricity
When pole connects electric pulse generator), wherein the pulse voltage of electricity ablation needs to meet to corresponding effect target area (i.e. organ lesion
Position) form irreversible electroporation.
The course of work of the cold probe of electricity of the invention are as follows:
After operation starts, it will be inserted into organ diseased region with bipolar electrode or the cold probe of multielectrode electricity, after determining position,
Freeze melting device is opened, starts to carry out diseased region cryoablation, while during starting freezing or rewarming, opening
DC generator is powered for electrode, since electrode is inserted in organ lesion position, is formed by the cell tissue liquid of diseased region
Electrical circuit, duration are powered meeting so that cell reaction constantly occurs around anodic-cathodic, and aggregation is a large amount of cationic around anode,
Make surrounding them that acidic environment be presented, assemble a large amount of anion around cathode, so that alkalinity is presented in surrounding them, peracid crosses alkali all
Cell Homeostasis structure can be destroyed and then lead to cell death；
Or in refrigerating process, electric pulse generator is opened, is powered for electrode, since electrode is inserted in organ lesion portion
Position, forms irreversible electroporation by cell of the electric pulse to diseased region by the clearly medical image in refrigerating process,
It generates cell membrane a large amount of permanent nanometer level microporous, to destroy intracellular steady state, promotes Apoptosis, eventually lead to cell
Thorough death.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of cold cold probe of ablating device electricity consumption of electricity, the cold probe of electricity is connect by connection component with host, and feature exists
In: the cold probe of electricity includes the shell being made of cutter head and knife bar and is set to the intracorporal air inlet pipe of shell, the cutter head shell
It is equipped at least two electrode, and mutually insulated between electrode.
2. a kind of cold cold probe of ablating device electricity consumption of electricity, the cold probe of electricity is connect by connection component with host, and feature exists
In: the cold probe of electricity includes the shell being made of cutter head and knife bar and is set to the intracorporal air inlet pipe of shell, the cutter head shell
With 1 electrode, and mutually insulated between electrode are respectively equipped on knife bar shell.
3. the cold cold probe of ablating device electricity consumption of electricity according to claim 1, it is characterised in that: be equipped with 2 in the cutter head
Electrode, the cutter head are divided into puncture portion, the first active region, insulation layer and the second active region, wherein first active region is corresponding
Inner walls be equipped with first electrode, the corresponding inner walls in the second active region be equipped with second electrode, it is described first electricity
Pole and second electrode pass through electrode cable and connect with host, and the corresponding housing wall of the insulation layer is insulation wall.
4. the cold cold probe of ablating device electricity consumption of electricity according to claim 1 or 2, it is characterised in that: be equipped in the cutter head
Thermometric galvanic couple, thermometric galvanic couple are connect by temperature measuring wire with host；At the knife bar other than the shell for being provided with electrode
It is equipped with heat insulation layer on partial shell inner wall, is equipped with electric insulation layer on outer wall.
5. the cold cold probe of ablating device electricity consumption of electricity according to claim 4, it is characterised in that: the cutter head and knife bar one
Molding；The thermometric galvanic couple is set to the cutter head enclosure interior.
6. the cold cold probe of ablating device electricity consumption of electricity according to claim 4, it is characterised in that: the thermometric galvanic couple is wherein
A piece temperature measuring wire and the electrode cable of the first electrode synthesize one, and the thermometric galvanic couple is used as first electrode simultaneously.
7. the cold cold probe of ablating device electricity consumption of electricity according to claim 1, it is characterised in that: the host includes control
Device, freeze melting device further include at least one of DC generator connected to the controller, electric pulse generator.
8. the cold cold probe of ablating device electricity consumption of electricity according to claim 7, it is characterised in that: the electric pulse generator hair
Penetrate the electric pulse of 100V~3000V.
9. the cold cold probe of ablating device electricity consumption of electricity according to claim 7, it is characterised in that: the DC generator and
An electrode assignment of logical device is additionally provided between electric pulse generator and the cold probe of electricity.
10. the cold cold probe of ablating device electricity consumption of electricity according to claim 7, it is characterised in that: the freeze melting device
In cold source be one of liquid nitrogen, nitrogen, argon gas, nitric oxide or carbon dioxide.
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