CN220735488U - Electric ablation system and ablation needle matched with cryoablation - Google Patents
Electric ablation system and ablation needle matched with cryoablation Download PDFInfo
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- CN220735488U CN220735488U CN202121470668.4U CN202121470668U CN220735488U CN 220735488 U CN220735488 U CN 220735488U CN 202121470668 U CN202121470668 U CN 202121470668U CN 220735488 U CN220735488 U CN 220735488U
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Abstract
The utility model relates to an electric ablation system and an ablation needle matched with cryoablation, wherein the ablation needle is provided with at least one conductive part, the conductive part is used for carrying out electric ablation on a target area, a cavity is arranged in the ablation needle, both ends of the ablation needle are provided with through holes, a cryoablation probe is assembled in the cavity to be matched with the ablation needle, and the ablation needle can be detached from the cryoablation probe and can independently carry out electric ablation; the electric ablation system comprises an electric generator and an ablation needle, the ablation needle is matched with the cryoprobe, a cryoablation system is also needed, the cryoablation system comprises a cryogenerator and a cryoablation probe, and any disclosed cryoablation probe can be selected as the cryoablation probe; the utility model has the technical advantages that the electric ablation can be independently carried out when the probe is not matched with the cryoablation probe, the cavity can be used for supplying medicine to the target area to achieve the effects of auxiliary ablation or coagulation and the like, and the treatment is flexible and changeable and is suitable for various application occasions.
Description
Technical Field
The utility model belongs to the field of medical appliances, and particularly relates to an electric ablation system and an ablation needle matched with cryoablation.
Background
Electric ablation is a common technical means in tumor ablation technology, and is an ablation technology based on a direct-current electric field, an alternating-current electric field or a pulsed electric field, including electrolytic ablation, electroporation ablation and the like. Electrolytic ablation has been used for as long as the 19 th century for minimally invasive tissue ablation, also known as electrochemical therapy (EChT) or electrochemical ablation, and is a method of delivering direct current into the treatment area through an electric melting needle inserted in the treated tissue, causing local pH changes in the treatment area to create a cytotoxic environment, and some new chemicals formed during electrolysis to cause cell death. Electrolytic ablation requires a small direct current (several tens to several hundreds of milliamperes) and a low voltage (several tens to several volts), and thus has a problem in that the treatment process of the electric ablation is long. Meanwhile, the electric ablation is not suitable for all patients or all focuses, and the treatment effect is poor under the condition that the length and the diameter of the solid tumor are larger than 5cm by taking a nanometer knife as an example; clinical trial observations in 2016 have found that nanoknives produce needle tract tumor implantation metastasis after surgery in 13% of patients on lung tumor ablation (another document indicates that similar events are found in liver tumors). The incidence of electrical ablation complications is significantly higher than with argon helium knife cryoablation techniques, so a combination of cryoablation and electrical ablation therapy is currently required in the marketplace.
Disclosure of Invention
The utility model aims to provide an electric ablation system and an ablation needle matched with cryoablation, and the device can be matched with a common puncture needle to perform electric ablation and matched with a cryoablation probe to perform electric and cold combined ablation.
In order to achieve the above purpose, the technical scheme of the utility model is realized as follows:
an electric ablation system and an ablation needle matched with cryoablation, wherein the ablation needle is matched with an electric generator and a cryogenerator for use, the electric generator is electrically connected with the ablation needle, at least one conductive part is arranged on the ablation needle and used for carrying out electric ablation on a target area, a cavity is formed in the ablation needle, through holes are formed in two ends of the ablation needle, a cryoablation probe is assembled in the cavity for matched ablation, the cryoablation probe is communicated with the cryogenerator, and the ablation needle can be detached from the cryoablation probe and is independently subjected to electric ablation.
Furthermore, one end of the ablation needle is provided with a puncture head, and the puncture head is detachably fixed with the ablation needle.
Further, the ablation needle is at least partially provided with a thermal insulation layer.
Further, the inner wall of the ablation needle is at least partially provided with an electrically insulating layer.
Further, the electrical generator is electrically connected to the cryoablation probe.
Further, the ablation needle is flexible.
Further, the ablation needle may be axially separated into at least two portions that may be spliced to one another.
Further, the conductive parts are provided with at least two, and an electric insulation area is arranged between every two conductive parts.
Further, a clamping structure is arranged on the ablation needle and is used for adapting to the cryoablation probes with different diameters.
The utility model also provides an electric ablation system matched with cryoablation, which comprises an electric generator and the ablation needle in the technical scheme, wherein a cavity is arranged in the ablation needle, the ablation needle is used for performing the electrolytic ablation, and the cavity is used for being matched with the cryoablation probe.
Furthermore, the electric ablation system further comprises a cryoablation system, the cryoablation system comprises a cryogenerator and a cryoablation probe, the cryoablation probe is inserted into a cavity in the ablation needle to be matched with the cavity, and the combined ablation needle can synchronously or asynchronously perform cryoablation and electric ablation.
The utility model has the following advantages: (1) The electric ablation can be independently carried out when the cryoablation probe is not matched, the internal cavity can be used for supplying medicine to the target area to achieve the effects of auxiliary ablation or coagulation and the like, and the treatment is flexible and changeable and suitable for various application occasions.
(2) The combination of freezing and electric ablation can be carried out by matching with the cryoablation probe, the matching structure is simple, the mode of electric ablation is changeable, and meanwhile, the electric ablation can be carried out by directly supplying power to the cryoablation probe.
(3) The specification can be set freely, and the probe can be matched with various sizes of cryoablation probes through a built-in clamping structure.
Drawings
FIG. 1 is a block diagram of an ablation system of the utility model
FIG. 2 is a schematic elevational cross-section of a single-conductor-area piercing-head-type ablation needle of the utility model
FIG. 3 is a schematic elevational cross-section of a dual-conductive-area penetration head type ablation needle of the utility model
FIG. 4 is a schematic front cross-sectional view of an ablation needle with a detachable tip in accordance with the present utility model
FIG. 5 is a schematic elevational cross-section of an ablation needle of the utility model without a piercing head and with a cryoablation probe
FIG. 6 is a schematic elevational view in cross-section of the present utility model without a beveled ablation needle at the proximal end of the tip and with a cryoablation probe
FIG. 7 is a schematic elevational view in cross-section of the proximal end of the utility model without a piercing tip, only partially conductive, and mated with a cryoablation probe
FIG. 8 is a schematic front cross-sectional view of a cavity of the present utility model provided with a flexible securing structure
FIG. 9 is a schematic elevational cross-section of a cavity of the present utility model with a flexible fixation structure in combination with a cryoablation probe
FIG. 10 is a schematic front cross-sectional view of a cryoablation probe with a snap-fit attachment structure on the surface of the probe
FIG. 11 is a schematic elevational view in cross-section of an axially detachable structure according to the utility model
FIG. 12 is a schematic elevational view in cross-section of the present utility model electrically ablated by a thermometry wire and mated with a cryoablation probe
In the figure: 101-first housing, 102-first piercing tip, 1021-first conductive part, 103-first lumen, 201-second housing, 202-second piercing tip, 203-second lumen, 301-third housing, 302-second conductive part, 3021-ramp-type conductive part, 303-third cavity, 304-temperature measuring wire
Detailed Description
The utility model mainly provides an electric ablation system matched with cryoablation, which is provided with an electric generator, wherein direct current for electrolysis and electric pulses with different frequency ranges for electroporation can be generated, the electric generator is placed in a target area to independently perform electric ablation on the target area, the electric ablation mode can be simple electrolysis or simple electric pulse or an ablation mode combining electrolysis and electric pulse, the electric pulse can lead to cell permeabilization, the specific electric pulse can lead to reversible/irreversible electroporation of cells, and in addition, TTF electric fields, radio frequency or microwaves can also be used as other modes of electric ablation. The ablation needle employed in connection with the features of the present utility model is hollow and at least partially electrically conductive in appearance, the hollow structure being used to configure a wire-type guide body which may be used only to provide a piercing function or may have different effects, a particular wire-type guide body may be electrically conductive, and a wire-type guide body with an electrically conductive function may serve as one electrode for electrical ablation. The linear guide body can also be a cryoablation probe, the cryoablation probe refers to a needle for ablating tumors by utilizing a low-temperature principle, the low-temperature mode of a target area comprises but is not limited to a refrigeration mode by a phase change principle, a refrigeration mode by a Joule Thomson principle and an electric refrigeration mode, the cryoablation probe can adopt a flexible structure or a rigid structure according to requirements, the currently disclosed cryoablation probe can be adapted to the utility model, the cryoablation probe can also be modified, and particularly can be a cryoablation probe with an insulation structure or a conductive structure for matching with electric ablation, after the cryoablation probe is matched with the utility model, the target area can be synchronously or asynchronously subjected to cryoablation and electric ablation, the effect of tumor ablation can be effectively improved by matching the cryoablation and the electric ablation, and the target area can be rewamed by outputting electric heating energy which can be heated through an electric generator in an electric ablation system during or after the ablation operation is completed.
In order to make the matching relationship between the present utility model and the linear guide body more stable, the present utility model and the linear guide body may have a structure fixed to each other, specifically, a clamping structure (refer to fig. 10) which can clamp the linear guide body inserted into the present utility model by arranging clamping joints from both ends of the through hole of the present utility model or from the outer wall; a flexible film (see fig. 8) may be provided inside the present utility model, and the present utility model may be closely attached to the linear guide body by the flexible film (see fig. 9), and a preferable material for the film is a biocompatible material having high thermal conductivity, such as medical hydrogel; it should be noted that the present utility model without a fixed structure can be used in the same manner as the linear guide by being tightly fitted, and the specifications commonly used in the conventional cryoablation probe include an outer diameter of 1.2mm, 1.4mm, 1.7mm, 2.0mm, 2.4mm, 3.8mm, etc., and the specifications not listed do not represent that the present utility model cannot be used with the needle of the specification, and the clamping structure can also be any structure manually/automatically adapted to the workpiece in the inner diameter in the prior art, and the use of the present utility model is not affected by adopting a similar structure.
The specific structure is as follows:
referring to fig. 1, fig. 1 is an ablation system of the present utility model, where the ablation system is composed of an electrical ablation system and a cryoablation system, both of which are disclosed technologies, and the difference is that an ablation needle connected to the electrical ablation system is provided with a cavity, and the cavity is used in combination with a cryoablation probe, where the cryoablation probe is a disclosed and suitable for being configured with any cryoablation probe of the ablation needle in the present system, and a detection module for detecting a physical quantity of a target area is further provided in the system, where the specific physical quantity may be an electrical characteristic such as current, voltage and/or impedance, or a temperature characteristic, and the physical quantity may reflect an operating state of one or more probes, for example, the impedance may reflect whether the plurality of probes are in contact with each other.
For a better understanding of the present utility model, the present utility model is further described below with reference to specific examples and drawings. However, it will be apparent to one skilled in the art that embodiments of the present disclosure may be practiced without these specific details. Furthermore, the particular embodiments of the present disclosure described herein are provided as examples and should not be used to limit the scope of the utility model to these particular embodiments. In other instances, well-known materials, components, processes, controller components, software, circuits, timing diagrams, and/or anatomical structures have not been described or shown in detail in order to avoid unnecessarily obscuring embodiments.
Example 1: referring to fig. 2, fig. 2 is a schematic diagram of an ablation needle with a puncture head in one form of the present utility model, which includes a first housing 101 and a first puncture head 102, wherein the first housing 101 is completely insulated, the first housing 101 may be a rigid structure or a flexible structure, the first puncture head 102 is conductive, a first inner cavity 103 is provided inside the first housing 101, and an electrical circuit is required for forming an electrical ablation, and a single electrode structure in this embodiment may be used to insert another conductor in a target area or to provide a surface electrode outside a patient.
Fig. 2 shows only one of the embodiments of the present structure, but in other embodiments the first piercing head 102 may be an insulating structure, but at the same time the first housing 101 should be provided with at least one conductive region, and the portion should be disposed at a portion of the needle near the target area so that the ablation region is located close to the first piercing head 102 during the ablation operation. Specifically, in this embodiment, at least one or more conductive portions should be disposed in the whole of the first housing 101 and the first puncture head 102. If more than one electrically conductive portion is provided, an electrically insulating layer should be provided between the two portions, as shown in fig. 3.
In fig. 3, a first conductive portion 1021 is provided on the first housing 101, and a portion between the first conductive portion 1021 and the puncture tip 102 having conductivity is an electrically insulating portion. The first inner cavity 103 may be inserted with a linear guide body for use, where the linear guide body may be rigid or flexible, and specifically which structure should be used in cooperation with the structure of the first housing 101, if the linear guide body is selected to be an at least partially conductive structure, the electric generator may be electrically connected to the linear guide body so as to make the first conductive portion 1021 and/or the first puncture head 102 conductive and further may perform electric ablation on the target area, if the conductive portion is not powered in this way, the electric ablation capability may be provided by directly electrically connecting the electric generator and the conductive portion directly, and this power supply principle may be applied to other implementation results of the embodiment at the same time; the linear guide may be a cryoablation probe, the cooperation of which with the first housing 101 provides the present embodiment with both the ability to cryoablate and electrically ablate the target area, and where the linear guide is a cryoablation probe, the first housing 101 has a preferred structure that is at least partially a thermally insulating material, the preferred structure being used with other implementations than the present embodiment.
The utility model adopts a close fit relation with the arranged linear guide body, and the close fit relation ensures that the two parts cannot be separated when the utility model is used because the two parts are penetrated into the target area or pulled out of the target area; it is preferable that the present embodiment can be fixed with the linear guide body by a clamping structure, particularly referring to fig. 9 and 10, by providing a flexible coating on the inner wall of the first housing 101 to make them closely fit or referring to fig. 8, providing a through hole on the surface of the first housing 101 and clamping the two by a clamping head, the above clamping structure can be applied to all examples of the present utility model or other implementation results beyond the present utility model by simple simulation, which should not be regarded as exceeding the scope of the present utility model.
Example 2: referring to fig. 4, fig. 4 is an ablation needle with a detachable puncture head according to the present utility model, including a second housing 201 and a second puncture head 202, where the second puncture head 202 and the second housing 201 are detachably fixed, and the detachable fixing manner may be a screwing manner in fig. 4, or any conventional detachable structure may be used, which does not affect implementation of the embodiment; the second housing 201 may be rigid or flexible, and the rigid housing is applied to a puncture type operation, and mainly acts on structures such as tissues or organs of a human body, and the flexible housing is applicable to structures such as natural passages and blood vessels of the human body.
Thus, the present configuration is advantageous in that the second piercing tip 202 can be removable and replaceable, and in particular, can be replaced with a non-piercing tip for use with a flexible housing, wherein the distribution of conductive portions can be referenced to the corresponding distribution in embodiment 1.
In addition, the second puncture head 202 can be removed and a linear guide body can be inserted into the second inner cavity 203 for matching use, the linear guide body can be flexible (such as guide wire), and the form is matched with the flexible second shell 201 to conduct ablation operation which reaches a target area; also rigid needles (e.g., cryoablation probes) are possible, and the combination preferably cooperates with a rigid second housing 201 for performing an ablation procedure to penetrate the target area.
Referring to fig. 11, fig. 11 is a preferred structure of the present embodiment, in which the linear guide body may be assembled with the ablation needle of the present utility model in a tight and inconvenient manner, so that the ablation needle may be axially split into at least 2 portions that can be combined with each other by means of a buckle or other conventional combination structure; when in use, the ablation needle is separated, the linear guide body is placed into the ablation needle and then the ablation needle is combined to complete the assembly, and the preferred structure can be applied to other embodiments of the utility model in the same way, and the protection scope of the utility model is beyond the embodiment of the utility model but adopting the same principle.
Example 3: referring to fig. 5, fig. 5 is a non-independent use type ablation needle of the present utility model, which includes a third housing 301, wherein the third housing 301 may be a rigid structure or a flexible structure, at least one second conductive portion 302 is provided on the third housing 301, and if there are a plurality of conductive portions, an electrical insulation structure is provided between every two conductive portions; the left and right ends of the third housing 301 are both open structures, a third inner cavity 303 is arranged in the middle of the third housing, and a puncture needle is arranged in the third inner cavity 303, so that the main function of the puncture needle is to provide a puncture function for the embodiment, the puncture needle can be partially conductive or an insulator, the preferred puncture needle is a cryoablation probe, and the embodiment matched with the cryoablation probe can synchronously/asynchronously perform cryoablation and electric ablation on a target area.
Referring to fig. 6, fig. 6 is a preferred structure of the ablation needle according to the present embodiment, in order to ensure that the ablation needle is easy to penetrate into the target area, an end of the third housing 301 near the target area is configured to have a slope shape, so as to form a slope-shaped conductive portion 3021, and the ablation needle is more easy to enter the target area in cooperation with the penetration needle inside the third inner cavity 303.
Referring to fig. 7, fig. 7 is another structure of the ablation needle according to this embodiment, the outer surface of the conventional cryoablation probe is generally made of conductive material, so that the portion of the inner wall of the third inner cavity 303, which is in contact with the cryoablation probe, is made of insulating material, and at least one second conductive portion 302 is disposed only on the portion of the surface of the third housing 301, and the structure shown in the drawing is disposed only on the outer surface of the third housing 301 but not on the inner surface of the third housing 301, so that the structure can ensure that the cryoablation probe matched with the inner portion is not conductive when power is supplied to the second conductive portion 302, and the controllability of the electric ablation area is enhanced. Thus, in use, the electrical generator may selectively energize the second conductive portion 302 or energize the cryoablation probe, thereby enabling the present structure to achieve the technical effect of producing electrical ablation between multiple electrodes of a single needle.
Referring to fig. 12, fig. 12 is another structure of the ablation needle according to the present embodiment, in which the third housing 301 may be an insulating structure, the temperature measurement wire 304 is disposed on the surface of the third housing 301, and the temperature measurement wire 304 is at least partially conductive, so that electrical ablation can be performed through the temperature measurement wire 304, and when the structure of part of the third housing 301 is a non-insulating structure, the structure can form a technical effect of generating electrical ablation between a plurality of electrodes of a needle.
When the ablation needle is used, the linear guide body is placed into the inner cavity of the ablation needle, the optimal linear guide body is a cryoablation probe, the ablation needle and the cryoablation probe are fixed through the self-adaptive close fit or clamping structure to complete combination, the combined needle is placed into a target area, then the cryoablation system and the electric ablation system are controlled by the ablation system respectively according to requirements so as to synchronously or asynchronously start the cryogenerator and the electric generator to ablate the target area, and then the ablation needle and the cryoablation probe are separated by taking out the needle, so that the use process is completed.
The foregoing describes the embodiments of the present utility model in detail, but the description is only a preferred embodiment of the present utility model and should not be construed as limiting the scope of the utility model. All equivalent changes and modifications within the scope of the present utility model are intended to be covered by this patent.
Claims (11)
1. An ablation needle of cooperation cryoablation, ablation needle cooperation electricity generator and cryogenerator use, electricity generator with ablation needle electricity is connected, its characterized in that: the ablation needle is provided with at least one conductive part, the conductive part is used for electrically ablating a target area, a cavity is formed in the ablation needle, through holes are formed in two ends of the ablation needle, a cryoablation probe is assembled in the cavity to perform matched ablation, the cryoablation probe is communicated with the cryogenerator, and the ablation needle can be detached from the cryoablation probe and can be independently subjected to electric ablation.
2. The ablation needle of claim 1, wherein: one end of the ablation needle is provided with a puncture head, and the puncture head is detachably fixed with the ablation needle.
3. The ablation needle of claim 1, wherein: the ablation needle is at least partially provided with a heat insulating layer.
4. The ablation needle of claim 1, wherein: the inner wall of the ablation needle is at least partially provided with an electrical insulation layer.
5. The ablation needle of claim 1, wherein: the electrical generator is electrically connected with the cryoablation probe.
6. The ablation needle of claim 1, wherein: the ablation needle is flexible.
7. The ablation needle of any of claims 1-6, wherein: the ablation needle may be axially separated into at least two portions that may be spliced to one another.
8. The ablation needle of any of claims 1-6, wherein: the conductive parts are provided with at least two, and an electric insulation area is arranged between every two conductive parts.
9. The ablation needle of any of claims 1-6, wherein: the ablation needle is provided with a clamping structure which is used for adapting to the cryoablation probes with different diameters.
10. An electrical ablation system for cooperating with cryoablation, characterized by: the electrical ablation system comprises an electrical generator and the ablation needle of any one of claims 1-6, wherein a cavity is arranged inside the ablation needle, the ablation needle is used for performing electrolytic ablation, and the cavity is used for being matched with the cryoablation probe.
11. The electrical ablation system of claim 10, wherein: the ablation system further comprises a cryoablation system, the cryoablation system comprises a cryogenerator and a cryoablation probe, the cryoablation probe is inserted into a cavity in the ablation needle to be matched with the cavity, and the combined ablation needle can synchronously or asynchronously perform cryoablation and electric ablation.
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