CN109467836A - A kind of medical PVC pump line material of super-elastic and preparation method thereof, application - Google Patents
A kind of medical PVC pump line material of super-elastic and preparation method thereof, application Download PDFInfo
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- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
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- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
- C08J3/246—Intercrosslinking of at least two polymers
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2327/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Derivatives of such polymers
- C08J2327/02—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Derivatives of such polymers not modified by chemical after-treatment
- C08J2327/04—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Derivatives of such polymers not modified by chemical after-treatment containing chlorine atoms
- C08J2327/06—Homopolymers or copolymers of vinyl chloride
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- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2425/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Derivatives of such polymers
- C08J2425/02—Homopolymers or copolymers of hydrocarbons
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- C08J2451/00—Characterised by the use of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers
- C08J2451/04—Characterised by the use of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers grafted on to rubbers
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- C08J2491/00—Characterised by the use of oils, fats or waxes; Derivatives thereof
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- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/09—Carboxylic acids; Metal salts thereof; Anhydrides thereof
- C08K5/098—Metal salts of carboxylic acids
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- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/10—Esters; Ether-esters
- C08K5/11—Esters; Ether-esters of acyclic polycarboxylic acids
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/10—Esters; Ether-esters
- C08K5/12—Esters; Ether-esters of cyclic polycarboxylic acids
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/16—Nitrogen-containing compounds
- C08K5/20—Carboxylic acid amides
Abstract
The invention discloses a kind of medical PVC pump line material of super-elastic, by weight, component includes at least: 80~100 parts of polyvinyl chloride resins, 5~15 parts of HIPS, 1~10 part of PS, 10~50 parts of primary plasticizers, 5~30 parts of extender plasticizers, 1~10 part of lubricant, 1~10 part of heat stabilizer, 0.1~1.4 part of antioxidant, 0.01~0.1 part of light stabilizer.
Description
Technical field
The present invention is applied to medical instruments field, in particular to the medical PVC pump line material of a kind of super-elastic and its preparation
Method, application.
Background technique
Extracorporeal circulation pipeline is mainly used for Cardio-pulmonary Operation and haemodialysis etc., belongs to three classes medical instrument.With medical skill
The continuous development of art and material science, more and more Cardiopulmonary Bypass are applied to clinically.Realize that these extracorporal circulatory systems are equal
Pipeline is needed to provide access, and wherein pump line is to provide the major power part of blood flow, therefore its performance is to treatment curative effect shadow
Sound is larger.Infusion pump in medical application is that one kind can accurately control infusion flow and guarantee that drug speed is uniform, dose is accurate and safe
Ground enters instrument in patient body, is clinically chiefly used in being transfused half-life short or the medication infusion with genotoxic potential, need
Accurate control transfusion time or defeated people amount.For majority infusion pump using peristaltic pump as power source, feature determines infusion stream at present
Directly related, the especially haemodialysis such as accuracy and material, elasticity, the internal diameter of the used pipeline of infusion pump (abbreviation pump line) of speed
The material resilience with higher that pipeline needs.
High molecular material has a wide range of applications in medical field, and wherein polyvinyl chloride (PVC) curable product is because of its item
It has excellent performance and is seized of consequence in medical field.PVC is needed to meet biological requirement: be used as medical material
The additives such as plasticizer, stabilizer it is nontoxic, and be not easy to ooze out from PVC material；With good biocompatibility, not teratogenesis
It is not carcinogenic, do not play allergic reaction；Good blood compatibility, haemolysis is low, anticoagulant property.
It cannot function as medical pump line since general PVC hose resilience is poor, be used for the pump of infusion pump on the market at present
In use, due to bear squeezing repeatedly, fatigue will occur after a certain period of use time for pipe, elasticity variation causes defeated
Liquid Dilution of Precision.Medical wriggling pump hose must have a good biocompatibility, also have certain elasticity, i.e., hose it is radial by
It can restore the characteristics such as shape after pressure rapidly.
Summary of the invention
In order to solve the above-mentioned technical problem, the first aspect of the invention provides a kind of medical PVC pump of super-elastic
Materials in the tube, by weight, component include at least:
As a kind of perferred technical scheme, HIPS melt index when condition is 200 DEG C/5kg is 3.6~16g/
10min；PS melt index when condition is 200 DEG C/5kg is 1.17~12g/10min.
As a kind of perferred technical scheme, the light stabilizer is selected from hindered amine light stabilizer, phenyl salicylate, benzo
One of triazole type, 4- (1- naphthyl azo) -1- naphthols, citric acid or a variety of combinations；
As a kind of perferred technical scheme, the primary plasticizer is DOP and/or trioctyl lemon acid；The auxiliary increases
Moulding agent is epoxidized soybean oil and/or epoxidized linseed oil.
As a kind of perferred technical scheme, the heat stabilizer is rare-earth stearate.
As a kind of perferred technical scheme, the rare-earth stearate is Lanthanum Stearate.
As a kind of perferred technical scheme, the antioxidant is Hinered phenols antioxidant and/or tetrapentaerythritol ester；
The lubricant is stearate and/or ethylene bis stearic acid amide.
As a kind of perferred technical scheme, the Hinered phenols antioxidant is selected from antioxidant 264, antioxidant 1076, resists
Oxygen agent 1010, one or more combinations of antioxidant 1098, antioxidant 2246-S, antioxidant 300, antioxidant KY-586.
As a kind of perferred technical scheme, the stearate is in zinc stearate, calcium stearate, odium stearate
One or more combinations.
The second aspect of the invention additionally provides the preparation method of the medical PVC pump line material, includes at least following step
It is rapid:
A, under the conditions of 30 DEG C~60 DEG C, first by polyvinyl chloride resin, HIPS, PS, primary plasticizer, lubricant, heat stabilizer, anti-
Oxidant, light stabilizer are added to mixing machine and are sufficiently blended 20~60 minutes, modified PVC are added into mixing machine, auxiliary increases
Agent is moulded, continues 1~5h of blending at 60 DEG C~100 DEG C and obtains mixture；
B, under the conditions of 170 DEG C~190 DEG C, mixture melting extrusion is granulated, and obtains mixing pellet；
C, mixing pellet is added in extruder, is melted, squeezed out, be cooled into pump line after traction；
D, it by the pump line in above-mentioned c, carries out gamma-ray irradiation and penetrates 0.5~12h, irradiation dose 25kGy.
Third aspect of the present invention provides the medical PVC pump line material applied to medical instruments field.
The utility model has the advantages that the present patent application provides medical PVC pump line material of a kind of super-elastic and preparation method thereof, answers
With gained medical PVC pump line material has very excellent super-elastic, and resilience is high, and pump line material can restore rapidly former after being pressurized
Shape, and there is very excellent mechanical intensity and fatigue durability, thus it is speculated that possible cause is to penetrate lower production in gamma-ray irradiation due to HIPS
Raw crosslinking, forms inierpeneirating network structure, so that elastic properties of materials and mechanical property get a promotion, gamma-ray irradiation is penetrated inside PVC
But also material internal generates crosslinking while lower sterilizing, avoids and bring cause in sterilizing using ethylene oxide material
Cancer harm.
The above-mentioned of the application and other features, aspects and advantages are more readily understood with reference to following detailed description.
Specific embodiment
For the purpose of following detailed description, it should be understood that the present invention can be used various substitutions variation and step it is suitable
Sequence, unless specifically stated on the contrary.In addition, being indicated in the case where in addition in any operational instances or otherwise pointing out
Such as all numbers of the amount of ingredient used in description and claims should be understood in all cases by term
" about " it modifies.Therefore, unless indicated to the contrary, the numerical parameter otherwise illustrated in the following description and appended dependent claims is root
The approximation changed according to the expected performance of the invention to be obtained.It is at least not intended to for the applicable of doctrine of equivalents being limited in
In the scope of the claims, each numerical parameter should at least be given up according to the number of the effective digital of report and by the way that application is common
Enter technology to explain.
Although illustrating that broad range of numberical range and parameter of the invention are approximations, listed in specific example
Numerical value is reported as accurately as possible.However, any numerical value inherently includes the standard deviation by finding in its each self-test measurement
The certain errors necessarily led to.
When a numberical range disclosed herein, above range is considered as continuously, and the minimum value including the range and most
Big value and each value between this minimum value and maximum value.Further, when range refers to integer, including the model
Each integer between minimum value and maximum value enclosed.In addition, when providing multiple range Expressive Features or characteristic, Ke Yihe
And the range.In other words, unless otherwise specified, otherwise all ranges disclosed herein are understood to include and are wherein included into
Any and all subrange.For example, should be regarded as including between minimum value 1 and maximum value 10 from the specified range of " 1 to 10 "
Any and all subrange.The Exemplary range of range 1 to 10 include but is not limited to 1 to 6.1,3.5 to 7.8,5.5 to
10 etc..
The first aspect of the invention provides a kind of medical PVC pump line material of super-elastic, and by weight, component is extremely
Include: less
In some preferred embodiments, the medical PVC pump line material of above-mentioned super-elastic, by weight, component
It includes at least:
In some preferred embodiments, the medical PVC pump line material of above-mentioned super-elastic, by weight, group
Divide and include at least:
PVC
In this application, the term " PVC " used is one kind of polyvinyl chloride ((Polyvinyl chloride, PVC))
Referred to as.
PVC used herein is medical catheter pellet (medical grade), is commercially available, can be purchased from Shanghai chlor-alkali plastic cement has
Limit company (medical grade) medical catheter pellet, can also be purchased from other companies.
HIPS、PS
In the present invention, used term " HIPS " is a kind of abbreviation of high impact polystyrene, is by a small amount of poly- fourth
Diene connects in skill to polystyrene matrix.With " island structure ", matrix is plastics, and dispersed phase is rubber.The term used
" PS " is a kind of abbreviation of polystyrene.
The numerical value of mobility when used term " melt index " is a kind of expression plastic material processing, by height to be measured
Molecule (plastics) raw material is placed in sulculus, and slot end is connected to tubule, capillary diameter 2.095mm, pipe range 8mm.It is heated to certain temperature
After degree, raw material upper end applies certain constant weight by piston and extrudes downwards, measures the weight that the raw material is extruded in 10 minutes
Amount, the as flow index of the plastics.Its value is bigger, indicates that the processing fluidity of the plastic material is better, on the contrary then poorer.
In some embodiments, the test condition of heretofore described melt index is 200 DEG C/5kg.
In some embodiments, the melt index of heretofore described HIPS is 3.6~16g/10min, and the PS is molten
Melting index is 1.17~12g/10min；Preferably, the melt index of the HIPS is 6.5~10g/10min, the PS melting
Index is 3.8~7g/10min；It is furthermore preferred that the melt index of the HIPS is 8g/10min, the PS melt index is
5.5g/10min。
HIPS and PS used in the present invention are commercially available, such as can be purchased from Shanghai match gram, Saudi Arabia sabic, the Taibei
Ningbo can also be purchased from other companies.
Plasticizer
In some embodiments, heretofore described primary plasticizer includes but is not limited to DOP, in trioctyl lemon acid,
The extender plasticizer includes but is not limited to epoxidized soybean oil, epoxidized linseed oil；
In some preferred embodiments, heretofore described primary plasticizer is trioctyl lemon acid, and the auxiliary increases
Modeling agent is epoxidized soybean oil；
In some preferred embodiments, heretofore described primary plasticizer is DOP, and the extender plasticizer is epoxy
Linseed oil；
In some embodiments, the term " DOP " in the present invention refers to dioctyl phthalate (Dioctyl
Phthalate abbreviation).
Heat stabilizer
In some embodiments, heretofore described heat stabilizer includes but is not limited to rare-earth stearate.
As a kind of perferred technical scheme, the rare-earth stearate is Lanthanum Stearate.
Antioxidant
In some embodiments, heretofore described antioxidant includes but is not limited to Hinered phenols antioxidant, the four seasons
Doutrate.
In the technical solution of some implementations, the Hinered phenols antioxidant includes but is not limited to: antioxidant 264, antioxidant
1076, antioxidant 1010, antioxidant 1098, antioxidant 2246-S, antioxidant 300, antioxidant KY-586；Preferably, described
Hinered phenols antioxidant is antioxidant 264.
Light stabilizer
In some embodiments, heretofore described light stabilizer includes but is not limited to hindered amine light stabilizer, bigcatkin willow
One of acid phenenyl ester, benzotriazole, 4- (1- naphthyl azo) -1- naphthols, citric acid are a variety of；
It include but is not limited to Ciba's HALS class in the heretofore described hindered amine light stabilizer of some embodiments
944,770,622,540,3346；Preferably, the light stabilizer is the 944 of Ciba HALS class.
Lubricant
In some embodiments, heretofore described lubricant includes but is not limited to stearate, the double stearic acid of ethylene
Amide.Preferably, the lubricant stearic acid salt is one of zinc stearate, calcium stearate, odium stearate or a variety of groups
It closes；It is furthermore preferred that the lubricant stearic acid zinc.
Modified PVC
In some embodiments, the synthesis mechanism of modified PVC described herein is, in PVC, C-Cl key be easy with
Nucleophilic substitution occurs for the mercapto groups of nucleophilicity, selects lauryl mercaptan to be reacted with PVC, introduces in PVC flexible
Nonpolar Long carbon chain alkyl group, obtains pectination PVC.
In some embodiments, above-mentioned pectination PVC can take sodium mercaptides to react with PVC and be made, and can also take other
Mode is made.
In some embodiments, it is as follows with PVC to react specific embodiment for above-mentioned sodium mercaptides:
1) prepare lauryl mercaptan sodium: the sodium ethoxide for weighing certain mass is dissolved in ethyl alcohol, after sodium ethoxide all dissolution,
It is added lauryl mercaptan in three-necked flask, at 80 DEG C, nitrogen protection back flow reaction, magnetic agitation 8h.To after reaction, rotate
Except ethyl alcohol, later, using the unreacted mercaptan of petroleum ether, sodium mercaptides are obtained；The ethyl alcohol is with lauryl mercaptan molar ratio
1:1。
2) mixed solution for the second alcohol and water that configuration molar ratio is 3:1 is in the beaker of 500ml.Weigh a certain amount of PVC
It is dissolved in tetrahydrofuran solvent, under nitrogen protection, completely, lauryl mercaptan sodium is added in reflux dissolution under the conditions of 55 DEG C, and stirring is anti-
Answer 12h.After, products therefrom is added dropwise in the mixed solution of second alcohol and water of configuration, washing filters, and obtains final product
Thiolation modified PVC；The PVC and lauryl mercaptan sodium molar ratio are 1:1.
Preparation method
The second aspect of the invention additionally provides the preparation method of medical PVC pump line material, at least includes the following steps:
A, under the conditions of 30 DEG C~60 DEG C, first by polyvinyl chloride resin, HIPS, PS, primary plasticizer, lubricant, heat stabilizer, anti-
Oxidant, light stabilizer are added to mixing machine and are sufficiently blended 20~60 minutes, modified PVC are added into mixing machine, auxiliary increases
Agent is moulded, continues 1~5h of blending at 60 DEG C~100 DEG C and obtains mixture；
B, under the conditions of 170 DEG C~190 DEG C, mixture melting extrusion is granulated, and obtains mixing pellet；
C, mixing pellet is added in extruder, melting extrusion is cooled into pump line after traction；
D, it by the pump line in above-mentioned c, carries out gamma-ray irradiation and penetrates 0.5~12h, irradiation dose 25kGy.
In some preferred embodiments, the application above-mentioned steps a conditional are as follows: 40 DEG C~55 DEG C conditions, first PVC tree
Rouge, HIPS, PS, primary plasticizer, lubricant, heat stabilizer, antioxidant, light stabilizer be added to mixing machine be sufficiently blended 30~
55 minutes, modified PVC, extender plasticizer are added into mixing machine, are continued 2~4h of blending at 70 DEG C~95 DEG C and are mixed
Material；It is furthermore preferred that above-mentioned steps a conditional are as follows: 50 DEG C of conditions, first polyvinyl chloride resin, HIPS, PS, primary plasticizer, lubricant, heat are steady
Determine agent, antioxidant, light stabilizer are added to mixing machine and are sufficiently blended 40 minutes, modified PVC, auxiliary are added into mixing machine
Plasticizer continues blending 3h at 90 DEG C and obtains mixture.
In some preferred embodiments, the application above-mentioned steps b conditional are as follows: melted under the conditions of 175 DEG C~185 DEG C
Melt extruding pelletization, obtains mixing pellet；It is furthermore preferred that melting extrusion is granulated under the conditions of 170 DEG C, mixing pellet is obtained.
In some embodiments, gamma-ray irradiation described herein is 0.5~12h；Preferably, the gamma-rays spoke
According to for 7~10h；It is furthermore preferred that the gamma-ray irradiation is 8h.
In some embodiments, the revolving speed of mixing machine described herein is 800~1200r/min；This preferred Shen
Please described in mixing machine revolving speed be 900~1100r/min；It is furthermore preferred that the revolving speed of mixing machine described herein is
1000r/min。
Using
Third aspect of the present invention provides medical PVC pump line material applied to medical instruments field；Preferably, in the application
The medical PVC pump line material can be applied to Cardio-pulmonary Operation and haemodialysis medical instruments field.
The unexpected discovery of applicant, the medical PVC pump line material prepare processing when, discovery PVC, HIPS, PS,
Modified PVC and remaining components system show good compatibility, single-phase uniform, thus it is speculated that possible cause is introduced in modified PVC
Long carbon chain nonpolar alkyl group, with same non-polar group have good compatibility so that system be blended it is more uniform,
In addition to this, the flexibility of Long carbon chain nonpolar alkyl group preferably, also improves PVC toughness to a certain extent.
If raw materials used to be all commercially available, army is purchased from traditional Chinese medicines chemical reagent without other explanations.
The present invention is specifically described below by embodiment.Following embodiment is served only for making furtherly the present invention
It is bright, it should not be understood as the limitation to the present invention, protection, professional and technical personnel in the field makes according to the content of foregoing invention
Nonessential modifications and adaptations, still fall within protection scope of the present invention.
Embodiment 1
The embodiment of the present invention 1 provides the medical PVC pump line material and preparation method, application of a kind of super-elastic, by weight
Part meter, component include at least:
Above-mentioned primary plasticizer is DOP, and extender plasticizer is epoxidized soybean oil, and lubricant is zinc stearate, and heat stabilizer is
Lanthanum Stearate, antioxidant are antioxidant 264, and light stabilizer is the 944 of Ciba HALS class；Melt index test condition is
When 200 DEG C/5kg, the melt index of the HIPS is 3.6g/10min, and the melt index of PS is 1.17g/10min.
The preparation method of elastomeric medical PVC pump line material, comprising the following steps:
A, 30 DEG C of conditions, first polyvinyl chloride resin, HIPS, PS, primary plasticizer, lubricant, heat stabilizer, antioxidant, light are stablized
Agent is added to mixing machine and is sufficiently blended 20 minutes, and modified PVC, extender plasticizer are added into mixing machine, continues at 60 DEG C altogether
Mixed 1h obtains mixture；
B, under the conditions of 170 DEG C, mixture melting extrusion is granulated, and obtains mixing pellet；
C, mixing pellet is added in extruder, melting extrusion is cooled into pump line after traction；
D, it by the pump line in above-mentioned c, carries out gamma-ray irradiation and penetrates 0.5h, irradiation dose 25kGy.
Elastomeric medical PVC pump line material is applied to medical instruments field.
Embodiment 2
The embodiment of the present invention 2 provides the medical PVC pump line material and preparation method, application of a kind of super-elastic, by weight
Part meter, component include at least:
Above-mentioned primary plasticizer is DOP, and extender plasticizer is epoxidized linseed oil, and lubricant is zinc stearate, and heat stabilizer is
Lanthanum Stearate, antioxidant are antioxidant 264, and light stabilizer is the 944 of Ciba HALS class；Melt index test condition is
When 200 DEG C/5kg, the melt index of the HIPS is 6.5g/10min, and the melt index of PS is 3.8g/10min.
The preparation method of elastomeric medical PVC pump line material, comprising the following steps:
A, 40 DEG C of conditions, first polyvinyl chloride resin, HIPS, PS, primary plasticizer, lubricant, heat stabilizer, antioxidant, light are stablized
Agent is added to mixing machine and is sufficiently blended 30 minutes, and modified PVC, extender plasticizer are added into mixing machine, continues at 70 DEG C altogether
Mixed 2h obtains mixture；
B, under the conditions of 175 DEG C, mixture melting extrusion is granulated, and obtains mixing pellet；
C, mixing pellet is added in extruder, melting extrusion is cooled into pump line after traction；
D, it by the pump line in above-mentioned c, carries out gamma-ray irradiation and penetrates 7h, irradiation dose 25kGy.
Elastomeric medical PVC pump line material is applied to medical instruments field.
Embodiment 3
The embodiment of the present invention 3 provides the medical PVC pump line material and preparation method, application of a kind of super-elastic, by weight
Part meter, component include at least:
Above-mentioned primary plasticizer is citric acid monooctyl ester, and extender plasticizer is epoxidized soybean oil, and lubricant is zinc stearate, and heat is steady
Determining agent is Lanthanum Stearate, and antioxidant is antioxidant 264, and light stabilizer is the 944 of Ciba HALS class；Melt index test
When condition is 200 DEG C/5kg, the melt index of the HIPS is 10g/10min, and the melt index of PS is 7g/10min.
The preparation method of elastomeric medical PVC pump line material, comprising the following steps:
A, 55 DEG C of conditions, first polyvinyl chloride resin, HIPS, PS, primary plasticizer, lubricant, heat stabilizer, antioxidant, light are stablized
Agent is added to mixing machine and is sufficiently blended 55 minutes, and modified PVC, extender plasticizer are added into mixing machine, continues at 95 DEG C altogether
Mixed 4h obtains mixture；
B, under the conditions of 185 DEG C, mixture melting extrusion is granulated, and obtains mixing pellet；
C, mixing pellet is added in extruder, melting extrusion is cooled into pump line after traction；
D, it by the pump line in above-mentioned c, carries out gamma-ray irradiation and penetrates 10h, irradiation dose 25kGy.
Elastomeric medical PVC pump line material is applied to medical instruments field.
Embodiment 4
The embodiment of the present invention 4 provides the medical PVC pump line material and preparation method, application of a kind of super-elastic, by weight
Part meter, component include at least:
Above-mentioned primary plasticizer is citric acid monooctyl ester, and extender plasticizer is epoxidized soybean oil, and lubricant is zinc stearate, and heat is steady
Determining agent is Lanthanum Stearate, and antioxidant is antioxidant 264, and light stabilizer is the 944 of Ciba HALS class；Melt index test
When condition is 200 DEG C/5kg, the melt index of the HIPS is 16g/10min, and the melt index of PS is 12g/10min.
The preparation method of elastomeric medical PVC pump line material, comprising the following steps:
A, 60 DEG C of conditions, first polyvinyl chloride resin, HIPS, PS, primary plasticizer, lubricant, heat stabilizer, antioxidant, light are stablized
Agent is added to mixing machine and is sufficiently blended 60 minutes, and modified PVC, extender plasticizer are added into mixing machine, continues at 100 DEG C altogether
Mixed 5h obtains mixture；
B, under the conditions of 190 DEG C, mixture melting extrusion is granulated, and obtains mixing pellet；
C, mixing pellet is added in extruder, melting extrusion is cooled into pump line after traction；
D, it by the pump line in above-mentioned c, carries out gamma-ray irradiation and penetrates 12h, irradiation dose 25kGy.
Elastomeric medical PVC pump line material is applied to medical instruments field.
Embodiment 5
The embodiment of the present invention 5 provides the medical PVC pump line material and preparation method, application of a kind of super-elastic, by weight
Part meter, component include at least:
Above-mentioned primary plasticizer is citric acid monooctyl ester, and extender plasticizer is epoxidized soybean oil, and lubricant is zinc stearate, and heat is steady
Determining agent is Lanthanum Stearate, and antioxidant is antioxidant 264, and light stabilizer is the 944 of Ciba HALS class；Melt index test
When condition is 200 DEG C/5kg, the melt index of the HIPS is 8g/10min, and the melt index of PS is 5.5g/10min.
The preparation method of elastomeric medical PVC pump line material, comprising the following steps:
A, 50 DEG C of conditions, first polyvinyl chloride resin, HIPS, PS, primary plasticizer, lubricant, heat stabilizer, antioxidant, light are stablized
Agent is added to mixing machine and is sufficiently blended 52 minutes, and modified PVC, extender plasticizer are added into mixing machine, continues at 90 DEG C altogether
Mixed 3h obtains mixture；
B, under the conditions of 180 DEG C, mixture melting extrusion is granulated, and obtains mixing pellet；
C, mixing pellet is added in extruder, melting extrusion is cooled into pump line after traction；
D, it by the pump line in above-mentioned c, carries out gamma-ray irradiation and penetrates 8h, irradiation dose 25kGy.
Elastomeric medical PVC pump line material is applied to medical instruments field.
Comparative example 1
Comparative example 1 of the present invention provides a kind of PVC pump line material and preparation method, except modified PVC becomes 0 especially, remaining group
Slitting part is identical with embodiment 5；
The preparation method that comparative example 1 provides PVC pump line material is identical with embodiment 5.Occur a large amount of groups in process
Poly- phenomenon.
Comparative example 2
Comparative example 2 of the present invention provides a kind of PVC pump line material and preparation method, by weight, except modified PVC becomes
0.1 especially, remaining component condition is identical with embodiment 5；
The preparation method that comparative example 2 provides PVC pump line material is identical with embodiment 5.Process has a small amount of reunion
Phenomenon.
Comparative example 3
Comparative example 3 of the present invention provides a kind of PVC pump line material and preparation method, by weight, except HIPS becomes 1 part
Outside, remaining component condition is identical with embodiment 5；
The preparation method that comparative example 3 provides PVC pump line material is identical with embodiment 5.
Comparative example 4
Comparative example 4 of the present invention provides a kind of PVC pump line material and preparation method, by weight, except HIPS becomes 50 parts
Outside, remaining component condition is identical with embodiment 5；
The preparation method that comparative example 4 provides PVC pump line material is identical with embodiment 5.
Comparative example 5
Comparative example 5 of the present invention provides a kind of PVC pump line material and preparation method, by weight, except HIPS becomes 0 part
Outside, remaining component condition is identical with embodiment 5；
The preparation method that comparative example 5 provides PVC pump line material is identical with embodiment 5.
Comparative example 6
Comparative example 6 of the present invention provides a kind of PVC pump line material and preparation method, by weight, except PS becomes 0 especially,
Remaining component condition is identical with embodiment 5；
The preparation method that comparative example 6 provides PVC pump line material is identical with embodiment 5.
Comparative example 7
Comparative example 7 of the present invention provides a kind of PVC pump line material and preparation method, and amounts of components condition is complete with embodiment 5
It is identical；
Comparative example 7 provides the preparation method of PVC pump line material, and without step d process in comparative example 7, remaining condition is the same as embodiment 5
It is identical.
Comparative example 8
Comparative example 8 of the present invention provides a kind of PVC pump line material and preparation method, and amounts of components condition is complete with embodiment 5
It is identical；
Comparative example 8 provides the preparation method of PVC pump line material, when gamma-ray irradiation described in step d process is penetrated in comparative example 8
Between become 0.5h, remaining condition is identical with embodiment 5.
Comparative example 9
Comparative example 9 of the present invention provides a kind of PVC pump line material and preparation method, and amounts of components condition is complete with embodiment 5
It is identical；
Comparative example 9 provides the preparation method of PVC pump line material, when gamma-ray irradiation described in step d process is penetrated in comparative example 9
Between become for 24 hours, remaining condition is identical with embodiment 5.
Comparative example 10
Comparative example 10 of the present invention provides a kind of PVC pump line material and preparation method, and amounts of components condition is complete with embodiment 5
It is identical；
Comparative example 10 provides the preparation method of PVC pump line material, and gamma-ray irradiation described in step d process is penetrated in comparative example 9
Become ethylene oxide sterilizing method, remaining condition is identical with embodiment 5.
Test method
(1) Mechanics Performance Testing
Tensile strength and elongation at break are measured according to D412-98a.
(2) antibacterial experiment is tested
By PVC pump line material prepared by Examples 1 to 5 and comparative example 1~10, and after washing, containing bacterium
Concentration is to shoot film surface bacterial number using scanning electron microscope after cultivating 36h in the LB nutrient solution of 100Cells/mL.
It is true, reliable to ensure to test, experiment accidental error is reduced, must obtain data with the average value of 3 repetition experiments.Test group
Average colony number refers to the step d conditional in this application, such as: gamma-ray irradiation is penetrated, ethylene oxide is sterilized, without sterilization
Processing, control group average colony number refers to blank control, without any sterilization processing mode.Test result calculations: residual bacterium rate=examination
A group average colony number/control group average colony number × 100% is tested, test result is shown in Table 1.
(3) biological property is evaluated
Biological property evaluation requires to carry out according to GB16886.
Example above-mentioned is merely illustrative, and is used to explain the present invention some features of the method.Appended right is wanted
The range as wide as possible for being intended to require to be contemplated that is sought, and embodiments as presented herein is only according to all possible implementation
The explanation of the embodiment of the combined selection of example.Therefore, the purpose of applicant is that the attached claims are not illustrated this hair
The exemplary selectional restriction of bright feature.Some numberical ranges used also include sub- model in the claims
It encloses, the variation in these ranges should also be construed to be covered by the attached claims in the conceived case.
Claims (10)
1. a kind of medical PVC pump line material of super-elastic, which is characterized in that by weight, component includes at least:
2. medical PVC pump line material according to claim 1, which is characterized in that the HIPS is when condition is 200 DEG C/5kg
Melt index is 3.6~16g/10min；PS melt index when condition is 200 DEG C/5kg is 1.17~12g/10min.
3. medical PVC pump line material according to claim 1, which is characterized in that the HIPS is when condition is 200 DEG C/5kg
Melt index is 6.5~10g/10min；PS melt index when condition is 200 DEG C/5kg is 3.8~7g/10min.
4. medical PVC pump line material according to claim 1, which is characterized in that the HIPS is when condition is 200 DEG C/5kg
Melt index is 8g/10min；PS melt index when condition is 200 DEG C/5kg is 5.5g/10min.
5. medical PVC pump line material according to claim 1, which is characterized in that it is steady that the light stabilizer is selected from hindered amine light
Determine one or more combinations of agent, phenyl salicylate, benzotriazole, 4- (1- naphthyl azo) -1- naphthols, citric acid.
6. medical PVC pump line material according to claim 1, which is characterized in that the primary plasticizer is DOP and/or lemon
Sour three monooctyl esters；The extender plasticizer is in epoxidized soybean oil and/or epoxidized linseed oil.
7. medical PVC pump line material according to claim 1, which is characterized in that the heat stabilizer is rare-earth stearate.
8. medical PVC pump line material according to claim 1, which is characterized in that the antioxidant is Hinered phenols antioxygen
Agent and/or tetrapentaerythritol ester；The lubricant is stearate and/or ethylene bis stearic acid amide.
9. the preparation method of described in any item medical PVC pump line material according to claim 1~8, at least includes the following steps:
A, under the conditions of 30 DEG C~60 DEG C, first by polyvinyl chloride resin, HIPS, PS, primary plasticizer, lubricant, heat stabilizer, anti-oxidant
Agent, light stabilizer are added in mixing machine, are sufficiently blended 20~60 minutes, and modified PVC, auxiliary plasticising are added into mixing machine
Agent continues 1~5h of blending at 60 DEG C~100 DEG C and obtains mixture；
B, under the conditions of 170 DEG C~190 DEG C, mixture melting extrusion is granulated, and obtains mixing pellet；
C, mixing pellet is added in extruder, melting extrusion is cooled into pump line after traction；
D, it by the pump line in above-mentioned c, carries out gamma-ray irradiation and penetrates 0.5~12h, irradiation dose 25kGy.
10. described in any item medical PVC pump line material according to claim 1~8, which is characterized in that the medical PVC pump line material
Applied to medical instruments field.
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| CN113388214A (en) * | 2021-06-22 | 2021-09-14 | 太仓迎聚新材料科技有限公司 | Peristaltic pump hose material and preparation method and application thereof |
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