CN109464664A - It is a kind of for alleviating the preparation method of the intelligent eye sticker of dry eye condition - Google Patents
It is a kind of for alleviating the preparation method of the intelligent eye sticker of dry eye condition Download PDFInfo
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- CN109464664A CN109464664A CN201811344617.XA CN201811344617A CN109464664A CN 109464664 A CN109464664 A CN 109464664A CN 201811344617 A CN201811344617 A CN 201811344617A CN 109464664 A CN109464664 A CN 109464664A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
- B22F1/05—Metallic powder characterised by the size or surface area of the particles
- B22F1/054—Nanosized particles
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- B—PERFORMING OPERATIONS; TRANSPORTING
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Abstract
The present invention relates to multi-functional nanometer material technical fields, more particularly, to a kind of for alleviating the preparation method of the intelligent eye sticker of dry eye condition.It is a kind of for alleviating the preparation method of the intelligent eye sticker of dry eye condition, include the following steps: first to prepare palladium gold-covered nano stick, again by gelatin and A-d solution allocation at mass fraction be 30% gelatin A-d solution in, and stirring forms solution under 40-50 degree water bath condition；Guarantee that 1% genipin solution and B-a liquor capacity ratio are 1:20, takes 1% genipin solution in solution B-a, stir evenly；Suitable solution B-b is drawn in 3d printed special die, instills 2-3 drop 20%FeCl on surface3Solution.One day is stood, is removed from the molds molding eye sticker after molding again；By eye sticker aperture after molding, temperature sensing material is implanted into eye sticker hole after molding.The photosensitive fever of intelligence eye sticker prepared by the present invention, stimulates lacrimal secretion, alleviates xerophthalmia, does not interfere just common eye, personalized, convenient and practical.
Description
Technical field
The present invention relates to multi-functional nanometer material technical fields, more particularly, to a kind of for alleviating the intelligence of dry eye condition
The preparation method of eye sticker.
Background technique
With popularizing for video terminal, the disease incidence of dry eyes is risen year by year.Its treatment is also main as one of ophthalmology
Problem.Currently, the most important method for the treatment of xerophthalmia is tear alternative medicine, local use artificial tears are wet to improve ocular
Degree and lubricating ability.However, due to the tears of human secretory be it is complicated, containing water, electrolyte, protein, lipid etc. so that
Artificial tears are difficult complete identical as natural tears.In addition, many commercially available artificial tears contain preservative, although concentration is very
It is low, but their damages to eye cell cannot be ignored.Currently, the infrared health eyeshade for treating and preventing xerophthalmia also exists
Occur in the market.However, most of in them are disposable or need to charge, and they need to interfere the normal of eyes
It uses.Therefore, there are still deficiencies in terms of convenience and the feature of environmental protection.It, can be with if intelligent eye protection material can be developed
The lacrimal secretion that human eye is automatically adjusted according to external light source intensity is even closed one's eyes without charging, artificial tears.This will be a kind of
More direct, energy saving, light, safe prevention dry eyes method.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art, adapt to reality and need, and provide a kind of for alleviating dry eyes
The preparation method of the intelligent eye sticker of symptom.
In order to achieve the object of the present invention, the technological means that the present invention uses are as follows:
It is a kind of for alleviating the preparation method of the intelligent eye sticker of dry eye condition, include the following steps:
Step A, the preparation of palladium gold-covered nano stick:
A) gold nanorods solution is synthesized using seed mediated growth method；
B) 2mM PdCl is configured in volumetric flask4 2-Solution；
C) 0.1M CTAB and 0.1M AA and 2mM PdCl are added into A-a solution4 2-Solution is mixed according to volume ratio: 200:
100:1:5 mixing；
D) be vigorously stirred and rock, stir and under 27-30 degree water bath condition, solution becomes brown after a period of time, 10 hours with
At Dark grey after upper, show the Pd hull shape on gold nanorods surface at；Then 10000rpm revolving speed be centrifuged up and down 30min with
On, centrifugation obtains purer palladium gold-covered nano stick afterwards twice, and suitable deionized water is added and obtains palladium gold-covered nano stick solution；
Step B, the preparation of intelligent eye sticker:
A) by gelatin and A-d solution allocation at mass fraction be 30% gelatin A-d solution in, and in 40-50 degree water bath condition
Lower stirring forms solution；
B) guarantee that 1% genipin solution and B-a liquor capacity ratio are 1:20, take 1% genipin solution in solution B-a, stirring is equal
It is even；
C) suitable solution B-b is drawn in 3d printed special die, instills 2-3 drop 20%FeCl on surface3Solution.It is quiet
It sets one day, is removed from the molds molding eye sticker after molding again；
D) by eye sticker aperture after molding, temperature sensing material is implanted into eye sticker hole after molding.
The temperature sensing material is using amino resins and octadecyl alcolol as main component.
Beneficial effects of the present invention:
1. photosensitive fever stimulates lacrimal secretion, alleviate xerophthalmia.
2. heat discoloration, eye is excessively used in warning.
3. without charging, energy conservation and environmental protection.
4. just common eye is not interfered, it is personalized, it is convenient and practical.
Detailed description of the invention
Fig. 1 is that the SEM of synthesized palladium gold-covered nano stick schemes, and pattern is regular rectangular parallelepiped structure, and size is about 50nm；
Fig. 2 is that Brilliant Eyes are attached to the radiation of visible light optical picture that front and back compares for a period of time；(upper figure is temperature sensing material before irradiation
For black；The following figure is after irradiating, and temperature sensing material is red)
Fig. 3 is that intelligent eye sticker is attached to the optical picture at human eye eyelid；
Fig. 4 is that intelligent eye sticker is attached to the front and back infrared thermal imaging figure of radiation of visible light for a period of time at human eye eyelid.(left figure is to shine
Before penetrating, temperature is relatively low；Right figure is temperature drift after irradiation).
Specific embodiment
Embodiment: referring to Fig. 1-4.
This patent core content is how using luminous energy to be converted into thermal energy, then stimulates the secretion of tear, prevents dry eyes.Cause
This needs a kind of optical-thermal conversion material, when selecting optical-thermal conversion material, finds in identical temperature and Chemical Physics environment item
Under part, palladium gold-covered nano stick has higher photothermal conversion efficiency than the pure palladium nanometer rods or proof gold nanometer rods of same dose.Cause
This, we select gold nanorods@palladium (GNRs@Pd) as optical-thermal conversion material and the core material of this item eye sticker, this
Eye sticker is attached on lachrymal gland, it can perceive various light, is then heated, and stimulates the secretion of lachrymal gland then to alleviate dry eyes
Disease.In addition, built-in temperature sensitive ink can change color with the temperature of eye sticker, to excessively being played a warning role using eyes.
Because it does not need to charge, the normal use of eyes is not interfered yet, it is more more environmentally friendly than common infrared glasses and conveniently.Accordingly
Experimental result also demonstrates its safety and validity in terms of alleviating xerophthalmia.
The invention discloses a kind of for alleviating the preparation method of the intelligent eye sticker of dry eye condition, includes the following steps:
Step A, the preparation of palladium gold-covered nano stick:
A) gold nanorods solution is synthesized using seed mediated growth method；
B) 2mM PdCl is configured in volumetric flask4 2-Solution；
C) 0.1M CTAB and 0.1M AA and 2mM PdCl are added into A-a solution4 2-Solution is mixed according to volume ratio: 200:
100:1:5 mixing；
D) be vigorously stirred and rock, stir and under 27-30 degree water bath condition, solution becomes brown after a period of time, 10 hours with
At Dark grey after upper, show the Pd hull shape on gold nanorods surface at；Then 10000rpm revolving speed be centrifuged up and down 30min with
On, centrifugation obtains purer palladium gold-covered nano stick afterwards twice, and suitable deionized water is added and obtains palladium gold-covered nano stick solution；
Step B, the preparation of intelligent eye sticker:
A) by gelatin and A-d solution allocation at mass fraction be 30% gelatin A-d solution in, and in 40-50 degree water bath condition
Lower stirring forms solution；
B) guarantee that 1% genipin solution and B-a liquor capacity ratio are 1:20, take 1% genipin solution in solution B-a, stirring is equal
It is even；
C) suitable solution B-b is drawn in 3d printed special die, instills 2-3 drop 20%FeCl on surface3Solution.It is quiet
It sets one day, is removed from the molds molding eye sticker after molding again；
D) by eye sticker aperture after molding, temperature sensing material is implanted into eye sticker hole after molding.
The temperature sensing material is using amino resins and octadecyl alcolol as main component.
Practical application experimental example one:
Alleviate the application for leading to dry eye condition using computer for a long time:
(a) intelligent eye sticker is affixed at wherein one eye eyeball eyelid；
(b) computer is opened, adjusts computer brightness to Conventional brightness, the film of viewing 3 hours or so.
(c) lacrimal river height, lacrimal secretion, the B grades of tests of average breakup time of tear film and furious analysis are carried out.
(d) compared with not pasting eye sticker group, the lacrimal river height of human eye after eye sticker is pasted, lacrimal secretion increases, and furious analysis
B grade scoring then reduce.First second breakup time of tear film of eye sticker group is not pasted to be remarkably decreased compared to control group, and pastes eye sticker group phase
Than then being slightly decreased in control group.
Practical application experimental example two: computer warning function is used for a long time
(a) intelligent eye sticker is affixed at the eyelid of two eyes
(b) computer work is used for a long time, and computer brightness is adjusted to normal mode and does not use eyeshield mode.
(c) the temperature sensing material color at eyelid in eye sticker is observed after a period of time；
(d) it finds that the temperature sensing material in eye sticker becomes red from black, illustrates with computer overlong time.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to be said using the present invention
Equivalents made by bright book and accompanying drawing content are applied directly or indirectly in relevant technical field, are similarly included in this hair
In bright scope of patent protection.
Claims (2)
1. a kind of for alleviating the preparation method of the intelligent eye sticker of dry eye condition, which comprises the steps of:
Step A, the preparation of palladium gold-covered nano stick:
A) gold nanorods solution is synthesized using seed mediated growth method；
B) 2mM PdCl is configured in volumetric flask4 2-Solution；
C) 0.1M CTAB and 0.1M AA and 2mM PdCl are added into A-a solution4 2-Solution is mixed according to volume ratio: 200:
100:1:5 mixing；
D) be vigorously stirred and rock, stir and under 27-30 degree water bath condition, solution becomes brown after a period of time, 10 hours with
At Dark grey after upper, show the Pd hull shape on gold nanorods surface at；Then 10000rpm revolving speed be centrifuged up and down 30min with
On, centrifugation obtains purer palladium gold-covered nano stick afterwards twice, and suitable deionized water is added and obtains palladium gold-covered nano stick solution；
Step B, the preparation of intelligent eye sticker:
A) by gelatin and A-d solution allocation at mass fraction be 30% gelatin A-d solution in, and in 40-50 degree water bath condition
Lower stirring forms solution；
B) guarantee that 1% genipin solution and B-a liquor capacity ratio are 1:20, take 1% genipin solution in solution B-a, stirring is equal
It is even；
C) suitable solution B-b is drawn in 3d printed special die, instills 2-3 drop 20%FeCl on surface3Solution,
One day is stood, is removed from the molds molding eye sticker after molding again；
D) by eye sticker aperture after molding, temperature sensing material is implanted into eye sticker hole after molding.
2. according to claim 1 a kind of for alleviating the preparation method of the intelligent eye sticker of dry eye condition, it is characterised in that:
The temperature sensing material is using amino resins and octadecyl alcolol as main component.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811344617.XA CN109464664B (en) | 2018-11-13 | 2018-11-13 | Preparation method of intelligent eye patch for relieving xerophthalmia symptoms |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811344617.XA CN109464664B (en) | 2018-11-13 | 2018-11-13 | Preparation method of intelligent eye patch for relieving xerophthalmia symptoms |
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| CN109464664A true CN109464664A (en) | 2019-03-15 |
| CN109464664B CN109464664B (en) | 2021-07-20 |
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2018
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