CN109464664B - Preparation method of intelligent eye patch for relieving xerophthalmia symptoms - Google Patents

Preparation method of intelligent eye patch for relieving xerophthalmia symptoms Download PDF

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CN109464664B
CN109464664B CN201811344617.XA CN201811344617A CN109464664B CN 109464664 B CN109464664 B CN 109464664B CN 201811344617 A CN201811344617 A CN 201811344617A CN 109464664 B CN109464664 B CN 109464664B
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eye patch
eye
gelatin
preparation
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CN109464664A (en
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王小磊
魏超超
庞雨莲
张旭
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Nanchang University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/05—Metallic powder characterised by the size or surface area of the particles
    • B22F1/054—Nanosized particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/17—Metallic particles coated with metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F9/00—Making metallic powder or suspensions thereof
    • B22F9/16—Making metallic powder or suspensions thereof using chemical processes
    • B22F9/18—Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds
    • B22F9/24—Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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Abstract

The invention relates to the technical field of multifunctional nano materials, in particular to a preparation method of an intelligent eye patch for relieving dry eye symptoms. A preparation method of an intelligent eye patch for relieving dry eye symptoms comprises the following steps: firstly, preparing a palladium-coated gold nanorod, preparing gelatin A-d solution with the mass fraction of 30% by mixing gelatin and the A-d solution, and stirring the gelatin A-d solution and the gelatin A-d solution under the condition of water bath at 40-50 ℃ to form solution; ensuring that the volume ratio of the 1% genipin solution to the B-a solution is 1: 20, taking 1% genipin solution to be mixed with the solution B-a, and stirring uniformly; sucking appropriate amount of solution B-B into a special 3d mold, and dripping 2-3 drops of 20% FeCl on the surface3And (3) solution. Standing for one day, and taking out the molded eye patch from the mold after molding; the molded eyeAnd (5) sticking the hole, and implanting the temperature-sensitive material into the formed eye sticking hole. The intelligent eye patch prepared by the invention is photosensitive and exothermic, stimulates the secretion of tears, relieves xerophthalmia, does not interfere normal eye use, can be customized in a personalized way, and is convenient and practical.

Description

Preparation method of intelligent eye patch for relieving xerophthalmia symptoms
Technical Field
The invention relates to the technical field of multifunctional nano materials, in particular to a preparation method of an intelligent eye patch for relieving dry eye symptoms.
Background
With the popularization of video terminals, the incidence of dry eye rises year by year. Its treatment also becomes a major ophthalmic problem. Currently, the most important method for treating dry eye is tear replacement therapy, in which artificial tears are used topically to improve ocular surface moisture and lubrication. However, since tears secreted from the human body are complicated and contain water, electrolytes, proteins, lipids, etc., artificial tears are difficult to be completely identical to natural tears. In addition, many of the commercially available artificial tears contain preservatives, although at very low concentrations, their damage to the eye cells cannot be neglected. Currently, infrared health care eye masks for the treatment and prevention of dry eye also appear on the market. However, most of them are disposable or require charging, and they need to interfere with the normal use of the eye. Therefore, there are still deficiencies in convenience and environmental friendliness. If an intelligent eye protection material can be developed, the tear secretion of human eyes can be automatically adjusted according to the intensity of an external light source without charging, artificial tears or even eye closure. It will be a more direct, energy-saving, lightweight, safe method for preventing dry eye.
Disclosure of Invention
The invention aims to overcome the defects of the prior art, adapt to the practical needs and provide a preparation method of an intelligent eye patch for relieving dry eye symptoms.
In order to realize the purpose of the invention, the technical means adopted by the invention are as follows:
a preparation method of an intelligent eye patch for relieving dry eye symptoms comprises the following steps:
step A, preparation of the palladium-coated gold nanorod:
a) synthesizing a gold nanorod solution by adopting a seed growth method;
b) 2mM PdCl in volumetric flask4 2-A solution;
c) to the A-a solution was added 0.1M CTAB and 0.1M AA and 2mM PdCl4 2-Mixing the solutions according to the volume ratio: 200:100:1: 5;
d) stirring vigorously and shaking, stirring, and under the condition of 27-30 ℃ water bath, after a period of time, the solution turns brown, and after more than 10 hours, the solution turns dark gray, which indicates that a Pd shell on the surface of the gold nanorod is formed; centrifuging at a rotating speed of 10000rpm for more than 30min up and down, centrifuging twice to obtain a relatively pure palladium-coated gold nanorod, and adding a proper amount of deionized water to obtain a palladium-coated gold nanorod solution;
step B, preparation of the intelligent eye patch:
a) preparing gelatin and the A-d solution into a gelatin A-d solution with the mass fraction of 30%, and stirring the gelatin A-d solution in a water bath at 40-50 ℃ to form a solution;
b) ensuring that the volume ratio of the 1% genipin solution to the B-a solution is 1: 20, taking 1% genipin solution to be mixed with the solution B-a, and stirring uniformly;
c) sucking appropriate amount of solution B-B into a special 3d mold, and dripping 2-3 drops of 20% FeCl on the surface3And (3) solution. Standing for one day, and taking out the molded eye patch from the mold after molding;
d) and (4) opening the formed eye patch, and implanting the temperature-sensitive material into the formed eye patch hole.
The temperature-sensitive material takes amino resin and octadecanol as main components.
The invention has the beneficial effects that:
1. the medicine can sense light, generate heat, stimulate tear secretion and relieve xerophthalmia.
2. The temperature is changed and the overuse of eyes is warned.
3. Charging is not needed, and the energy-saving and environment-friendly effects are achieved.
4. The eye-protection glasses do not interfere normal use of eyes, can be customized individually, and are convenient and practical.
Drawings
FIG. 1 is an SEM image of the synthesized Pd-coated Au nanorod, which has a regular cuboid structure and a size of about 50 nm;
FIG. 2 is an optical diagram of the smart eye patch before and after exposure to visible light for a period of time; (the upper graph shows that the temperature sensitive material is black before irradiation, and the lower graph shows that the temperature sensitive material is red after irradiation)
FIG. 3 is an optical view of the smart eye patch applied to a person's eyelid;
fig. 4 is a front infrared thermal imaging image and a back infrared thermal imaging image of the intelligent eye patch attached to the eyelid of a human and irradiated by visible light for a period of time. (the left panel shows a lower temperature before irradiation, and the right panel shows a higher temperature after irradiation).
Detailed Description
Example (b): see fig. 1-4.
The key content of the patent is how to convert light energy into heat energy and then stimulate the secretion of tears to prevent dry eyes. Therefore, there is a need for a photothermal conversion material, and when the photothermal conversion material is selected, it is found that the palladium-coated gold nanorods have higher photothermal conversion efficiency than pure palladium nanorods or pure gold nanorods at the same dosage under the same temperature and chemical physical environment conditions. Therefore, gold nanorods @ palladium (GNRs @ Pd) are selected as a photothermal conversion material and also are core materials of the eye patch, the eye patch is pasted on lacrimal glands, and the eye patch can sense various light rays, then heat the light rays and stimulate secretions of the lacrimal glands to relieve xerophthalmia. In addition, the color of the built-in temperature-sensitive ink can be changed along with the temperature of the eye patch, and the built-in temperature-sensitive ink plays a role in warning overuse of eyes. Because it does not need to charge, also does not disturb the normal use of the eyes, it is more environment-friendly and more convenient than the ordinary infrared glasses. The corresponding experimental results also demonstrate its safety and effectiveness in relieving dry eye.
The invention discloses a preparation method of an intelligent eye patch for relieving dry eye symptoms, which comprises the following steps:
step A, preparation of the palladium-coated gold nanorod:
a) synthesizing a gold nanorod solution by adopting a seed growth method;
b) 2mM PdCl in volumetric flask4 2-A solution;
c) to the A-a solution was added 0.1M CTAB and 0.1M AA and 2mM PdCl4 2-Mixing the solutions according to the volume ratio: 200:100:1: 5;
d) stirring vigorously and shaking, stirring, and under the condition of 27-30 ℃ water bath, after a period of time, the solution turns brown, and after more than 10 hours, the solution turns dark gray, which indicates that a Pd shell on the surface of the gold nanorod is formed; centrifuging at a rotating speed of 10000rpm for more than 30min up and down, centrifuging twice to obtain a relatively pure palladium-coated gold nanorod, and adding a proper amount of deionized water to obtain a palladium-coated gold nanorod solution;
step B, preparation of the intelligent eye patch:
a) preparing gelatin and the A-d solution into a gelatin A-d solution with the mass fraction of 30%, and stirring the gelatin A-d solution in a water bath at 40-50 ℃ to form a solution;
b) ensuring that the volume ratio of the 1% genipin solution to the B-a solution is 1: 20, taking 1% genipin solution to be mixed with the solution B-a, and stirring uniformly;
c) sucking appropriate amount of solution B-B into a special 3d mold, and dripping 2-3 drops of 20% FeCl on the surface3And (3) solution. Standing for one day, and taking out the molded eye patch from the mold after molding;
d) and (4) opening the formed eye patch, and implanting the temperature-sensitive material into the formed eye patch hole.
The temperature-sensitive material takes amino resin and octadecanol as main components.
Practical application experimental example one:
use to alleviate dry eye symptoms caused by prolonged use of computers:
(a) the intelligent eye patch is stuck to one eyelid of one eye;
(b) and starting the computer, adjusting the brightness of the computer to the conventional brightness, and watching the film for about 3 hours.
(c) Tear river height, tear secretion volume, mean tear film break up time, and eye red analysis class B tests were performed.
(d) The lacrimal river height of the human eyes after eye patch application was increased, the amount of lacrimal secretion was increased, and the grade B score of the eye red analysis was decreased, compared to the non-eye patch group. Tear film break-up time was significantly decreased in the first second of the no-eye patch group compared to the control group, while the eye patch group was slightly decreased compared to the control group.
Practical application experiment example two: warning function for long time use of computer
(a) Paste intelligent eye paste on eyelids of two eyes
(b) When the computer is used for working for a long time, the brightness of the computer is adjusted to the conventional mode, namely the eye protection mode is not used.
(c) Observing the color of the temperature-sensitive material in the eye patch at the eyelid after a period of time;
(d) the temperature-sensitive material in the eye patch is found to be changed from black to red, which indicates that the computer is used for too long time.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent modifications made by the present invention and the contents of the drawings or directly or indirectly applied to the related technical fields are included in the scope of the present invention.

Claims (1)

1. A preparation method of an intelligent eye patch for relieving dry eye symptoms is characterized by comprising the following steps:
step A, preparation of the palladium-coated gold nanorod:
a) synthesizing a gold nanorod solution A-a by adopting a seed growth method;
b) 2mM PdCl in volumetric flask4 2-Solution A-b;
c) to the A-a solution was added 0.1M CTAB and 0.1M ascorbic acid AA and 2mM PdCl4 2-Mixing the solutions according to the volume ratio: 200:100:1: 5;
d) stirring vigorously and shaking, stirring and under the condition of 27-30 ℃ water bath, wherein the solution turns brown after a period of time and becomes dark gray after 10 hours, which indicates that a Pd shell on the surface of the gold nanorod is formed; centrifuging at a rotating speed of 10000rpm for more than 30min, centrifuging twice to obtain a relatively pure palladium-coated gold nanorod, and adding a proper amount of deionized water to obtain palladium-coated gold nanorod solutions A-d;
step B, preparation of the intelligent eye patch:
a) preparing gelatin and the A-d solution into a gelatin A-d solution with the mass fraction of 30%, and stirring the gelatin A-d solution in a water bath at 40-50 ℃ to form a solution B-a;
b) ensuring that the volume ratio of the 1% genipin solution to the B-a solution is 1: 20, putting 1% genipin solution into the solution B-a, and uniformly stirring to obtain a solution B-B;
c) sucking appropriate amount of solution B-B into a special 3d mold, and dripping 2-3 drops of 20% FeCl on the surface3Standing the solution for one day, and taking out the formed eye patch from the mold after forming;
d) and (3) opening the formed eye patch, and implanting a temperature-sensitive material into the formed eye patch hole, wherein the temperature-sensitive material takes amino resin and octadecanol as main components.
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