CN109464533A - A kind of preparation method of the small ball of Bazhen Pills - Google Patents

A kind of preparation method of the small ball of Bazhen Pills Download PDF

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Publication number
CN109464533A
CN109464533A CN201811588686.5A CN201811588686A CN109464533A CN 109464533 A CN109464533 A CN 109464533A CN 201811588686 A CN201811588686 A CN 201811588686A CN 109464533 A CN109464533 A CN 109464533A
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small ball
preparation
bazhen pills
powder
bazhen
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贾德君
孙大忠
韩姗姗
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Harbin Han Jun Pharmaceutical Co Ltd
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Harbin Han Jun Pharmaceutical Co Ltd
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia

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Abstract

A kind of preparation method of the small ball of Bazhen Pills, is related to a kind of preparation method of small ball of Chinese medicine.Preparation method: one, it is mixed after crushing the prepared slices of Chinese crude drugs；Two, dry；Three, it crushes, total mix；Four, medicine is refined；Five, pill grain；Six, ball, polishing, microwave drying are sieved；Seven, ball, coating is selected to obtain the small ball of Bazhen Pills.The small ball diameter of Bazhen Pills of the method for the present invention preparation is 2.2~2.5mm, and pellet shape rounding, color, weight are unified always.The method that the present invention prepares the small ball of Bazhen Pills is different from the prior art, process equipment require it is low, it is at low cost, technology difficulty is small, overcome the problem that small ball is easy stick to each other during the preparation process.

Description

A kind of preparation method of the small ball of Bazhen Pills
Technical field
The present invention relates to a kind of preparation methods of the small ball of Chinese medicine.
Background technique
The effect of Bazhen Pills has and tonifies the liver and kidney for tonifying recipes, blood nourishing and hair.Kidney deficiency and liver is cured mainly, caused by deficiency of blood wind is contained Alopecia areata symptoms include hair fall in flakes or to all fall off, mostly with dizziness have a sleepless night；Dizzy tinnitus, soreness and weakness of waist and knees；It is alopecia areata, complete Bald, general alopecia is shown in above-mentioned patient.
Existing Bazhen Pills is according to State Food and Drug Administration standard YBZ13102009 or 2015 standards of pharmacopoeia (water Honeyed bolus, big honeyed bolus) it is all the general pill of water.
Summary of the invention
The object of the present invention is to provide a kind of method for preparing the small ball of Bazhen Pills, by Bazhen Pills be prepared into diameter 2.2~ The small ball of 2.5mm has good appearance, good fluidity；Drug release is stablized；Be conducive to drug ingedient absorption, bioavilability is high； The stability of drug can be improved, the incompatibility between a variety of drugs is such as avoided, slow down drug degradation speed；Drug is reduced to digestion The irritation in road, the advantages that covering the uncomfortable taste of some drugs.
The method that the present invention prepares the small ball of Bazhen Pills sequentially includes the following steps:
One, it is mixed in proportion after crushing Radix Codonopsis, rhizoma atractylodis macrocephalae, Poria cocos, Radix Glycyrrhizae, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong and Rehmannia glutinosa；
Two, the prepared slices of Chinese crude drugs powder accumulation that step 1 mixes is got up and ulking thickness < 3cm, be subsequently placed in 105 DEG C~ Sterilize 60 ± 5min in 110 DEG C of environment, be placed on that vacuum degree -0.05MPa~-0.1MPa, vacuum is dry in 80 ± 2 DEG C of environment Dry 240 ± 10min；
Three, it is ground into 100 targeted fine powder of partial size < by the prepared slices of Chinese crude drugs powder that step 2 sterilizes, then total mix；
Four, prepared slices of Chinese crude drugs fine powder and cornstarch are mixed, then takes out 1%~2% mixed powder；Then by mixing silty Purified water is added in the 30%~35% of amount, continues to be stirred 5~10min；High quality medicine refining machine is sent into later to refine medicine 2~3 times；
Five, the medicine that step 4 is refined is sticked together and is put into pellet processing machine, adjustment sliver exporting speed is 12~25Hz, cutter speed be 12~ 25Hz；It dusts during the particles falling down cut out, the powder sprayed is the mixed powder that step 4 is taken out；Then it is sent into pellet rolling Shaft screen, the revolving speed of pellet rotary screen are 5~20 turns/min, and the inclination angle of pellet rotary screen roller is 0 °~10 °；
Six, ball, polishing, microwave drying are sieved；Temperature of charge≤115 DEG C, drop temperature≤128 in microwave drying drying process DEG C, and temperature difference >=10 DEG C of temperature of charge and drop temperature；
Seven, ball, coating is selected to obtain the small ball of Bazhen Pills.
Preparation method of the present invention is used as medicine using full medicine, and the active constituent of the prepared slices of Chinese crude drugs used does not lose, drug effect system more general than water Ball is more preferable.
The small ball diameter of Bazhen Pills of the method for the present invention preparation is 2.2~2.5mm, pellet shape rounding, color, weight one It is straight unified.The method that the present invention prepares the small ball of Bazhen Pills is different from the prior art, and process equipment requires low, at low cost, technique Difficulty is small, overcomes the problem that small ball is easy stick to each other during the preparation process.
The small ball of Bazhen Pills of the method for the present invention preparation is the film-coating water-bindered pill, shows lark after removing film-coating；Gas is fragrant, taste Sweet tea, slight bitter；The small ball moisture of Bazhen Pills is no more than 8.0%；It can all be leached in 40 minutes.The eight delicacies of the method for the present invention preparation The small ball of ball is per (4.6g) containing Radix Paeoniae Alba with Paeoniflorin (C23H28O11) meter, it must not be less than 8.4mg, with stable excellent of property of drug Point.
Specific embodiment
The technical solution of the present invention is not limited to the following list, further includes between each specific embodiment Any combination.
Specific embodiment 1: the method that present embodiment prepares the small ball of Bazhen Pills sequentially includes the following steps:
One, it is mixed in proportion after crushing Radix Codonopsis, rhizoma atractylodis macrocephalae, Poria cocos, Radix Glycyrrhizae, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong and Rehmannia glutinosa；
Two, the prepared slices of Chinese crude drugs powder accumulation that step 1 mixes is got up and ulking thickness < 3cm, be subsequently placed in 105 DEG C~ Sterilize 60 ± 5min in 110 DEG C of environment, be placed on that vacuum degree -0.05MPa~-0.1MPa, vacuum is dry in 80 ± 2 DEG C of environment Dry 240 ± 10min；
Three, it is ground into 100 targeted fine powder of partial size < by the prepared slices of Chinese crude drugs powder that step 2 sterilizes, then total mix；
Four, prepared slices of Chinese crude drugs fine powder and cornstarch are mixed, then takes out 1%~2% mixed powder；Then by mixing silty Purified water is added in the 30%~35% of amount, continues to be stirred 5~10min；High quality medicine refining machine is sent into later to refine medicine 2~3 times；
Five, the medicine that step 4 is refined is sticked together and is put into pellet processing machine, adjustment sliver exporting speed is 12~25Hz, cutter speed be 12~ 25Hz, cutter surface spray concentration are 95% ethyl alcohol, guarantee cutter lubrication；It dusts, is sprayed during the particles falling down cut out Powder be step 4 take out mixed powder；It is then sent into pellet rotary screen, the revolving speed of pellet rotary screen is 5~20 turns/min, The inclination angle of pellet rotary screen roller is 0 °~10 °；
Six, ball, polishing, microwave drying are sieved；Temperature of charge≤115 DEG C, drop temperature≤128 in microwave drying drying process DEG C, and temperature difference >=10 DEG C of temperature of charge and drop temperature；
Seven, ball, coating is selected to obtain the small ball of Bazhen Pills.
The cutter knife face of pellet processing machine described in present embodiment step 5 has segmentation crack.
Temperature difference >=10 DEG C of temperature of charge and drop temperature can reduce the temperature difference, and preventing product from expanding with heat and contract with cold influences product Quality.
Specific embodiment 2: the difference of present embodiment and specific embodiment one is: Radix Codonopsis, rhizoma atractylodis macrocephalae, Poria cocos, Radix Glycyrrhizae, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong and Rehmannia glutinosa are crushed in the ratio of 109g, 109g, 109g, 55g, 164g, 109g, 82g, 164g After mix.Other steps and parameter are identical as embodiment one.
Specific embodiment 3: the difference of present embodiment and specific embodiment one or two is: step 1 Radix Codonopsis is fried Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Glycyrrhizae, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong and Rehmannia glutinosa are ground into 80~120 mesh.Other steps and parameter and embodiment party Formula one or two is identical.
Specific embodiment 4: the difference of present embodiment and specific embodiment one, two or three is: step 3 will in Medicine medicine materical crude slice fine powder is put into total mix in trough type mixing machine, mixing time 30min.Other steps and parameter and embodiment One, two or three is identical.
Specific embodiment 5: the difference of present embodiment and specific embodiment one, two, three or four is: step 4 Middle prepared slices of Chinese crude drugs fine powder and cornstarch are mixed in 9:1 ratio.Other steps and parameter and embodiment one, two, three or four phases Together.
Specific embodiment 6: the difference of present embodiment and specific embodiment one, two, three, four or five is: step Purified water is slowly uniformly added into mixed powder in four, a length of 20~30min when adding water.Other steps and parameter and embodiment one, Two, three, four or five are identical.
Specific embodiment 7: the difference of present embodiment and one of specific embodiment one to six is: step 5 institute The well-regulated segmentation crack of cutter knife face of pellet processing machine is stated, segmentation crack protrusion (raised cell on similar tortoise plastron) is that shape is unified Polygon or round, segmentation crack projection area≤0.08mm2；And segmentation crack groove (crackle) width < 0.1mm, segmentation crack are recessed Groove depth is greater than 0 and to be less than 0.1mm.Other steps and parameter are identical as one of embodiment one to six.
Segmentation crack facilitates particle and separates with cutter.
Specific embodiment 8: the difference of present embodiment and one of specific embodiment one to seven is: step 5 institute The mouth that dusts to dust is stated as upper and lower N row, N is the natural number more than or equal to 2.Other steps and parameter and embodiment one to seven it One is identical.
Specific embodiment 9: the difference of present embodiment and one of specific embodiment one to eight is: step 5 institute The mouth that dusts to dust is stated to be separately positioned on different side walls；The mouth that dusts on different lateral is in same level or different water Plane.Other steps and parameter are identical as one of embodiment one to eight.
Preferably, the mouth that dusts is arranged on 2 opposite side walls.
Specific embodiment 10: the difference of present embodiment and one of specific embodiment one to nine is: in step 5 Mouth injection pressure of dusting on different lateral is different.Other steps and parameter are identical as one of embodiment one to nine.
Preferably, the same row being arranged on 2 opposite side walls mouth injection pressure of dusting is different.
Preferably, the same row being arranged on 2 opposite side walls mouth injection pressure of dusting is different, and adjacent row dusts mouth injection Pressure difference is opposite.
Present embodiment is conducive to roll during particles falling down, and all standing can be achieved in fine powder on particle, and thickness is equal One.
Specific embodiment 11: the difference of present embodiment and one of specific embodiment one to nine is: step 5 Middle difference dust mouth injection pressure it is different.Other steps and parameter are identical as one of embodiment one to nine.
The small ball preparation method of 1 Bazhen Pills of embodiment:
One, will Radix Codonopsis, rhizoma atractylodis macrocephalae, Poria cocos, Radix Glycyrrhizae, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong and Rehmannia glutinosa crush after by 109g, 109g, The ratio of 109g, 55g, 164g, 109g, 82g, 164g mix after being crushed to 80~120 mesh；
Two, the prepared slices of Chinese crude drugs powder accumulation that step 1 mixes is got up and ulking thickness < 3cm, be subsequently placed in 105 DEG C~ Sterilize 60min in 110 DEG C of environment, be placed on vacuum degree -0.05MPa~-0.1MPa, be dried in vacuo 240 in 80 DEG C of environment ±10min；
Three, it is ground into 100 targeted fine powder of partial size < by the prepared slices of Chinese crude drugs powder that step 2 sterilizes, then total mix, total mix Time is 30min；
Four, prepared slices of Chinese crude drugs fine powder and cornstarch are mixed in 9:1 ratio, then takes out 1%~2% mixed powder；Then It is slowly uniformly added into purified water by the 35% of mixed powder quality, a length of 25min, continues to be stirred 5~10min when adding water；It High quality medicine refining machine is sent into afterwards to refine medicine 2~3 times；
Five, the medicine that step 4 is refined is sticked together and is put into pellet processing machine, adjustment sliver exporting speed is 12Hz, cutter speed is 12Hz；It cuts Knife surface spray concentration is 95% ethyl alcohol, guarantees cutter lubrication；It dusts during the particles falling down cut out, the powder sprayed is The mixed powder that step 4 is taken out；It is then sent into pellet rotary screen, the revolving speed of pellet rotary screen is 10 turns/min, the rolling of pellet rotary screen The inclination angle of cylinder is 5 °；
Six, ball, polishing, microwave drying are sieved；Temperature of charge≤115 DEG C, drop temperature≤128 in microwave drying drying process DEG C, and temperature difference >=10 DEG C of temperature of charge and drop temperature；
Seven, ball, coating is selected to obtain the small ball of Bazhen Pills.
Wherein, the well-regulated segmentation crack of cutter knife face of pellet processing machine, segmentation crack protrusion is (similar to unit raised on tortoise plastron Lattice) it is the unified regular hexagon shape of shape, segmentation crack projection area is 0.08mm2；And segmentation crack groove (crackle) width is 0.08mm, segmentation crack depth of groove are 0.05mm.
The mouth that dusts to dust described in present embodiment step 5 is upper and lower 2 row, and 2 opposite side walls are arranged in the mouth that dusts On, the same row being arranged on 2 opposite side walls mouth injection pressure of dusting is different, and adjacent row mouth injection pressure difference of dusting is opposite.
The small ball diameter of Bazhen Pills of the present embodiment method preparation is 0.8~0.9mm, pellet shape rounding, color, weight Unify always.
The small ball of Bazhen Pills of the present embodiment method preparation is the film-coating water-bindered pill, shows lark after removing film-coating；Gas is fragrant, Sweet, slight bitter；The small ball moisture of Bazhen Pills is 7.4%；It can all be leached in 33 minutes in 36 DEG C of warm water.The present embodiment method The every 4.6g of the small ball of the Bazhen Pills of preparation is containing Radix Paeoniae Alba with Paeoniflorin (C23H28O11) it is calculated as 8.9mg.
And by the every lg of Bazhen Pills water-honeyed pill of 2015 standards of pharmacopoeia preparation containing Radix Paeoniae Alba with Paeoniflorin (C23H28O11) be 0.64mg。

Claims (10)

1. a kind of preparation method of the small ball of Bazhen Pills, it is characterised in that this method prepares the small ball of Bazhen Pills according to the following steps:
One, it is mixed in proportion after crushing Radix Codonopsis, rhizoma atractylodis macrocephalae, Poria cocos, Radix Glycyrrhizae, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong and Rehmannia glutinosa；
Two, the prepared slices of Chinese crude drugs powder accumulation that step 1 mixes is got up and ulking thickness < 3cm, is subsequently placed in 105 DEG C~110 Sterilize 60 ± 5min in DEG C environment, be placed on vacuum degree -0.05MPa~-0.1MPa, be dried in vacuo in 80 ± 2 DEG C of environment 240±10min；
Three, it is ground into 100 targeted fine powder of partial size < by the prepared slices of Chinese crude drugs powder that step 2 sterilizes, then total mix；
Four, prepared slices of Chinese crude drugs fine powder and cornstarch are mixed, then takes out 1%~2% mixed powder；Then by mixed powder quality 30%~35% is added purified water, continues to be stirred 5~10min；High quality medicine refining machine is sent into later to refine medicine 2~3 times；
Five, the medicine that step 4 is refined is sticked together and is put into pellet processing machine, adjustment sliver exporting speed is 12~25Hz, cutter speed be 12~ 25Hz；It dusts during the particles falling down cut out, the powder sprayed is the mixed powder that step 4 is taken out；Then it is sent into pellet rolling Shaft screen, the revolving speed of pellet rotary screen are 5~20 turns/min, and the inclination angle of pellet rotary screen roller is 0 °~10 °；
Six, ball, polishing, microwave drying are sieved；Temperature of charge≤115 DEG C, drop temperature≤128 DEG C in microwave drying drying process, And temperature difference >=10 DEG C of temperature of charge and drop temperature；
Seven, ball, coating is selected to obtain the small ball of Bazhen Pills.
2. a kind of preparation method of the small ball of Bazhen Pills according to claim 1, it is characterised in that Radix Codonopsis, rhizoma atractylodis macrocephalae, Fu Siberian cocklebur, Radix Glycyrrhizae, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong and Rehmannia glutinosa in 109g, 109g, 109g, 55g, 164g, 109g, 82g, 164g ratio powder Mixing after broken.
3. a kind of preparation method of the small ball of Bazhen Pills according to claim 1, it is characterised in that step 1 Radix Codonopsis, stir-fry are white Art, Poria cocos, Radix Glycyrrhizae, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong and Rehmannia glutinosa are ground into 80~120 mesh.
4. a kind of preparation method of the small ball of Bazhen Pills according to claim 1, it is characterised in that step 3 drinks Chinese medicine Piece fine powder is put into total mix in trough type mixing machine, mixing time 30min.
5. a kind of preparation method of the small ball of Bazhen Pills according to claim 1, it is characterised in that Chinese medicine is drunk in step 4 Piece fine powder and cornstarch are mixed in 9:1 ratio.
6. a kind of preparation method of the small ball of Bazhen Pills according to claim 1, it is characterised in that purified water in step 4 It is slowly uniformly added into mixed powder, a length of 20~30min when adding water.
7. a kind of preparation method of the small ball of Bazhen Pills according to claim 1, it is characterised in that pill described in step 5 The well-regulated segmentation crack of cutter knife face of machine, segmentation crack protrusion are the unified polygon or round of shape, segmentation crack projection area ≤0.08mm2；And segmentation crack recess width < 0.1mm, segmentation crack depth of groove are greater than 0 and to be less than 0.1mm.
8. a kind of preparation method of the small ball of Bazhen Pills according to claim 1, it is characterised in that dust described in step 5 The mouth that dusts for upper and lower N row, N is natural number more than or equal to 2.
9. a kind of preparation method of the small ball of Bazhen Pills according to claim 1 or 8, it is characterised in that sprayed described in step 5 The mouth that dusts of powder is separately positioned on different side walls；The mouth that dusts on different lateral is in same level or different level Face.
10. a kind of according to claim 1, preparation method of the small ball of Bazhen Pills described in 8 or 9, it is characterised in that in rapid five not It is different with the mouth injection pressure of dusting on side wall.
CN201811588686.5A 2018-12-25 2018-12-25 A kind of preparation method of the small ball of Bazhen Pills Pending CN109464533A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103520357A (en) * 2013-10-17 2014-01-22 浙江维康药业有限公司 Eight-gem pill (pellet) for tonifying vitality and benefiting blood

Patent Citations (1)

* Cited by examiner, † Cited by third party
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Application publication date: 20190315