CN109464477A - A kind of pomegranate rind extract pellet preparations and preparation method thereof - Google Patents
A kind of pomegranate rind extract pellet preparations and preparation method thereof Download PDFInfo
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- CN109464477A CN109464477A CN201811356850.XA CN201811356850A CN109464477A CN 109464477 A CN109464477 A CN 109464477A CN 201811356850 A CN201811356850 A CN 201811356850A CN 109464477 A CN109464477 A CN 109464477A
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- Prior art keywords
- pomegranate rind
- rind extract
- parts
- excipient
- pellet preparations
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- 239000000284 extract Substances 0.000 title claims abstract description 62
- 241000219991 Lythraceae Species 0.000 title claims abstract description 53
- 235000014360 Punica granatum Nutrition 0.000 title claims abstract description 53
- 241000283690 Bos taurus Species 0.000 title claims abstract description 52
- 239000008188 pellet Substances 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 44
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 41
- 239000000853 adhesive Substances 0.000 claims abstract description 22
- 230000001070 adhesive effect Effects 0.000 claims abstract description 22
- 239000000843 powder Substances 0.000 claims abstract description 13
- 239000000463 material Substances 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 5
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 5
- 239000001856 Ethyl cellulose Substances 0.000 claims description 5
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 5
- 108010010803 Gelatin Proteins 0.000 claims description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 5
- 229920002678 cellulose Polymers 0.000 claims description 5
- 239000001913 cellulose Substances 0.000 claims description 5
- 235000010980 cellulose Nutrition 0.000 claims description 5
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 5
- 229960004756 ethanol Drugs 0.000 claims description 5
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 5
- 229920001249 ethyl cellulose Polymers 0.000 claims description 5
- 229920000159 gelatin Polymers 0.000 claims description 5
- 239000008273 gelatin Substances 0.000 claims description 5
- 235000019322 gelatine Nutrition 0.000 claims description 5
- 235000011852 gelatine desserts Nutrition 0.000 claims description 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 5
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 5
- 239000008101 lactose Substances 0.000 claims description 5
- 229920000609 methyl cellulose Polymers 0.000 claims description 5
- 239000001923 methylcellulose Substances 0.000 claims description 5
- 235000010981 methylcellulose Nutrition 0.000 claims description 5
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 5
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
- 238000003541 multi-stage reaction Methods 0.000 claims description 5
- 238000004062 sedimentation Methods 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
- -1 polyethylene Polymers 0.000 claims description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 150000004040 pyrrolidinones Chemical class 0.000 claims 1
- 238000002604 ultrasonography Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 abstract description 8
- 239000002775 capsule Substances 0.000 abstract description 4
- 238000004090 dissolution Methods 0.000 abstract description 3
- 210000004051 gastric juice Anatomy 0.000 abstract description 3
- 238000007599 discharging Methods 0.000 abstract 1
- 238000005457 optimization Methods 0.000 description 7
- 239000004925 Acrylic resin Substances 0.000 description 4
- 229920000178 Acrylic resin Polymers 0.000 description 4
- 238000001694 spray drying Methods 0.000 description 4
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 3
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229960002179 ephedrine Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000009941 weaving Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
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Abstract
The invention discloses a kind of pomegranate rind extract pellet preparations and preparation method thereof, it is prepared by pomegranate rind extract and pharmaceutic adjuvant, pharmaceutic adjuvant is excipient and adhesive, pomegranate rind extract parts by weight content is 20~28 parts in its pellet preparations, the parts by weight content of excipient is 60~75 parts, and the parts by weight content of adhesive is 6~9 parts.Pomegranate rind extract and excipient have been carried out sufficient crushing by the present invention, it has been distributed to pomegranate rind extract in excipient well, and partial size has reached micro powder grade, pellet is made with such material, during discharging in vivo, principal component can discharge rapidly out with the dissolution of excipient, and every capsule of this product is made of the small pellet unit of several hundred grains, diffusional area is big in vivo, the specific surface area contacted with gastric juice is also big, Gu bioavilability is high so that this product works rapidly after taking.
Description
Technical field
The invention belongs to yarn weaving fields, and in particular to a kind of pomegranate rind extract pellet preparations and preparation method thereof.
Background technique
The various folk prescription health care products of pomegranate rind extract are more, currently, the product about pomegranate rind extract is deep by vast
The approval of consumer, these products are common tablets and capsules in addition to for single preparations of ephedrine substantially, but above-mentioned dosage form exists
Disintegration time is long；A certain position point disintegration in vivo, there is certain irritation to gastric mucosa；The disadvantages such as bioavilability is low.
Based on the above issues, this product has been made by the pellet technology transfer quickly grown in field of medicaments to field of food for we
The compound micro-pill type product that release is controllable in vivo and bioavilability is high, preferably to meet the needs of the majority of consumers.
Summary of the invention
Goal of the invention: in order to solve the deficiencies in the prior art, the present invention provides a kind of pomegranate rind extract pellet preparations
And preparation method thereof.
Technical solution: a kind of pomegranate rind extract pellet preparations are prepared, medicine by pomegranate rind extract and pharmaceutic adjuvant
It is excipient and adhesive with auxiliary material, pomegranate rind extract parts by weight content is 20~28 parts in pellet preparations, excipient
Parts by weight content be 60~75 parts, the parts by weight content of adhesive is 6~9 parts.
As optimization: the excipient is starch, microcrystalline cellulose, lactose, methylcellulose, carboxymethyl cellulose
One or more of sodium, polyvinylpyrrolidone, ethyl cellulose, acrylic resin, hydroxypropyl methyl cellulose and gelatin
Mixture.
As optimization: the adhesive is one of polyvinylpyrrolidone, cellulose family, resinae, animal acid
Or several mixture.
A kind of preparation method of the pomegranate rind extract pellet preparations, includes the following steps:
(1) granatum is crushed to 40~100 mesh；
(2) it takes water as a solvent, granatum is extracted using ultrasonic-microwave composite reaction system, obtains granatum
Extracting solution；
(3) granatum extracting solution is filtered using spiral discharge sedimentation centrifuge；
(4) organic film concentrated extract is used；
(5) dry gained concentrated extract, obtains pomegranate rind extract powder；
(6) pomegranate rind extract powder is taken, excipient is added, is crushed to the rank of micronization, is mixed；
(7) adhesive is dissolved in the solution of water, dehydrated alcohol or hydrous ethanol；
(8) pellet is made using Centrifugal fluidized pellet method.
As optimization: the solid-liquid ratio of the granatum and water is 1:23-34Kg/L.
As optimization: the ultrasonic power of the ultrasonic wave is 830W-1100W；Microwave power is 300W-500W.
As optimization: the Extracting temperature is 74 DEG C -82 DEG C；Extraction time is -3.5 hours 2.5 hours.
As optimization: the aperture of the organic film is 4nm-8nm.
As optimization: inlet air temperature when the described spray drying is 210 DEG C -230 DEG C, 94 DEG C -110 DEG C of leaving air temp.
The utility model has the advantages that pomegranate rind extract and excipient have been carried out sufficient crushing by the present invention, make pomegranate rind extract
It has been distributed in excipient well, and partial size has reached micro powder grade, pellet has been made with such material, the mistake discharged in vivo
Cheng Zhong, principal component can discharge rapidly out with the dissolution of excipient, and every capsule of this product is by small micro- of several hundred grains
Ball unit composition, diffusional area is big in vivo, and the specific surface area contacted with gastric juice is also big, Gu so that this product work after taking it is fast
Speed, bioavilability are high.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, so that the technology of this field
Personnel can better understand advantages and features of the invention, to make apparent boundary to protection scope of the present invention
It is fixed.Embodiment described in the invention is only a part of the embodiment of the present invention, instead of all the embodiments, based on the present invention
In embodiment, those of ordinary skill in the art's every other implementation obtained without making creative work
Example, shall fall within the protection scope of the present invention.
Specific embodiment 1
A kind of pomegranate rind extract pellet preparations, are prepared by pomegranate rind extract and pharmaceutic adjuvant, and pharmaceutic adjuvant is
Excipient and adhesive, pomegranate rind extract parts by weight content is 20 parts in pellet preparations, and the parts by weight of excipient contain
Amount is 60 parts, and the parts by weight content of adhesive is 6 parts.
The excipient is starch, microcrystalline cellulose, lactose, methylcellulose, sodium carboxymethylcellulose, polyethylene pyrrole
The mixture of one or more of pyrrolidone, ethyl cellulose, acrylic resin, hydroxypropyl methyl cellulose and gelatin.
The adhesive is the mixed of one or more of polyvinylpyrrolidone, cellulose family, resinae, animal acid
Close object.
A kind of preparation method of the pomegranate rind extract pellet preparations, includes the following steps:
(1) granatum is crushed to 40 mesh；
(2) it takes water as a solvent, granatum is extracted using ultrasonic-microwave composite reaction system, obtains granatum
Extracting solution；
(3) granatum extracting solution is filtered using spiral discharge sedimentation centrifuge；
(4) organic film concentrated extract is used；
(5) dry gained concentrated extract, obtains pomegranate rind extract powder；
(6) pomegranate rind extract powder is taken, excipient is added, is crushed to the rank of micronization, is mixed；
(7) adhesive is dissolved in the solution of water, dehydrated alcohol or hydrous ethanol；
(8) pellet is made using Centrifugal fluidized pellet method.
The solid-liquid ratio of the granatum and water is 1:23Kg/L.The ultrasonic power of the ultrasonic wave is 830W；Microwave
Power is 300W.The Extracting temperature is 74 DEG C -82 DEG C；Extraction time is 2.5 hours.The aperture of the organic film is
4nm.Inlet air temperature when the described spray drying is 210 DEG C, 94 DEG C of leaving air temp.
Specific embodiment 2
A kind of pomegranate rind extract pellet preparations, are prepared by pomegranate rind extract and pharmaceutic adjuvant, and pharmaceutic adjuvant is
Excipient and adhesive, pomegranate rind extract parts by weight content is 28 parts in pellet preparations, and the parts by weight of excipient contain
Amount is 75 parts, and the parts by weight content of adhesive is 9 parts.
The excipient is starch, microcrystalline cellulose, lactose, methylcellulose, sodium carboxymethylcellulose, polyethylene pyrrole
The mixture of one or more of pyrrolidone, ethyl cellulose, acrylic resin, hydroxypropyl methyl cellulose and gelatin.
The adhesive is the mixed of one or more of polyvinylpyrrolidone, cellulose family, resinae, animal acid
Close object.
A kind of preparation method of the pomegranate rind extract pellet preparations, includes the following steps:
(1) granatum is crushed to 100 mesh；
(2) it takes water as a solvent, granatum is extracted using ultrasonic-microwave composite reaction system, obtains granatum
Extracting solution；
(3) granatum extracting solution is filtered using spiral discharge sedimentation centrifuge；
(4) organic film concentrated extract is used；
(5) dry gained concentrated extract, obtains pomegranate rind extract powder；
(6) pomegranate rind extract powder is taken, excipient is added, is crushed to the rank of micronization, is mixed；
(7) adhesive is dissolved in the solution of water, dehydrated alcohol or hydrous ethanol；
(8) pellet is made using Centrifugal fluidized pellet method.
The solid-liquid ratio of the granatum and water is 1:34Kg/L.The ultrasonic power of the ultrasonic wave is 1100W；Microwave
Power is 500W.The Extracting temperature is 82 DEG C；Extraction time is 3.5 hours.The aperture of the organic film is 8nm.Institute
The inlet air temperature when spray drying stated is 230 DEG C, 110 DEG C of leaving air temp.
Specific embodiment 3
A kind of pomegranate rind extract pellet preparations, are prepared by pomegranate rind extract and pharmaceutic adjuvant, and pharmaceutic adjuvant is
Excipient and adhesive, pomegranate rind extract parts by weight content is 26 parts in pellet preparations, and the parts by weight of excipient contain
Amount is 69 parts, and the parts by weight content of adhesive is 8 parts.
The excipient is starch, microcrystalline cellulose, lactose, methylcellulose, sodium carboxymethylcellulose, polyethylene pyrrole
The mixture of one or more of pyrrolidone, ethyl cellulose, acrylic resin, hydroxypropyl methyl cellulose and gelatin.
The adhesive is the mixed of one or more of polyvinylpyrrolidone, cellulose family, resinae, animal acid
Close object.
A kind of preparation method of the pomegranate rind extract pellet preparations, includes the following steps:
(1) granatum is crushed to 80 mesh；
(2) it takes water as a solvent, granatum is extracted using ultrasonic-microwave composite reaction system, obtains granatum
Extracting solution；
(3) granatum extracting solution is filtered using spiral discharge sedimentation centrifuge；
(4) organic film concentrated extract is used；
(5) dry gained concentrated extract, obtains pomegranate rind extract powder；
(6) pomegranate rind extract powder is taken, excipient is added, is crushed to the rank of micronization, is mixed；
(7) adhesive is dissolved in the solution of water, dehydrated alcohol or hydrous ethanol；
(8) pellet is made using Centrifugal fluidized pellet method.
The solid-liquid ratio of the granatum and water is 1:28Kg/L.The ultrasonic power of the ultrasonic wave is 1000W；Microwave
Power is 400W.The Extracting temperature is 78 DEG C；Extraction time is 3.0 hours.The aperture of the organic film is 6nm.Institute
The inlet air temperature when spray drying stated is 220 DEG C, 104 DEG C of leaving air temp.
Pomegranate rind extract and excipient have been carried out sufficient crushing by the present invention, disperse pomegranate rind extract well
Arrived in excipient, and partial size has reached micro powder grade, pellet be made with such material, in vivo discharge during, it is main at
Dividing can discharge rapidly out with the dissolution of excipient, and every capsule of this product is the pellet unit group small by several hundred grains
At, diffusional area is big in vivo, and the specific surface area contacted with gastric juice is also big, Gu so that this product works rapidly after taking, biology is sharp
Expenditure is high.
Claims (9)
1. a kind of pomegranate rind extract pellet preparations, it is characterised in that: be prepared by pomegranate rind extract and pharmaceutic adjuvant, medicine
It is excipient and adhesive with auxiliary material, pomegranate rind extract parts by weight content is 20~28 parts in pellet preparations, excipient
Parts by weight content be 60~75 parts, the parts by weight content of adhesive is 6~9 parts.
2. pomegranate rind extract pellet preparations according to claim 1, it is characterised in that: the excipient be starch,
Microcrystalline cellulose, lactose, methylcellulose, sodium carboxymethylcellulose, polyvinylpyrrolidone, ethyl cellulose, acrylic acid tree
The mixture of one or more of rouge, hydroxypropyl methyl cellulose and gelatin.
3. pomegranate rind extract pellet preparations according to claim 1, it is characterised in that: the adhesive is polyethylene
The mixture of one or more of pyrrolidones, cellulose family, resinae, animal acid.
4. a kind of preparation method of pomegranate rind extract pellet preparations according to claim 1, it is characterised in that: including such as
Lower step:
(1) granatum is crushed to 40~100 mesh；
(2) it takes water as a solvent, granatum is extracted using ultrasonic-microwave composite reaction system, obtain granatum extraction
Liquid；
(3) granatum extracting solution is filtered using spiral discharge sedimentation centrifuge；
(4) organic film concentrated extract is used；
(5) dry gained concentrated extract, obtains pomegranate rind extract powder；
(6) pomegranate rind extract powder is taken, excipient is added, is crushed to the rank of micronization, is mixed；
(7) adhesive is dissolved in the solution of water, dehydrated alcohol or hydrous ethanol；
(8) pellet is made using Centrifugal fluidized pellet method.
5. the preparation method of pomegranate rind extract pellet preparations according to claim 1, it is characterised in that: the pomegranate
The solid-liquid ratio of Pi Yushui is 1:23-34Kg/L.
6. the preparation method of pomegranate rind extract pellet preparations according to claim 1, it is characterised in that: the ultrasound
The ultrasonic power of wave is 830W-1100W；Microwave power is 300W-500W.
7. the preparation method of pomegranate rind extract pellet preparations according to claim 1, it is characterised in that: the extraction
Temperature is 74 DEG C -82 DEG C；Extraction time is -3.5 hours 2.5 hours.
8. the preparation method of pomegranate rind extract pellet preparations according to claim 1, it is characterised in that: described is organic
The aperture of film is 4nm-8nm.
9. the preparation method of pomegranate rind extract pellet preparations according to claim 1, it is characterised in that: described is sprayed
Inlet air temperature when dry is 210 DEG C -230 DEG C, 94 DEG C -110 DEG C of leaving air temp.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703546A (en) * | 2009-11-20 | 2010-05-12 | 天津市弗兰德医药科技发展有限公司 | Sanchi extract pellets and preparation method thereof |
| CN102462744A (en) * | 2010-11-19 | 2012-05-23 | 天津尖峰弗兰德医药科技发展有限公司 | Cortex moutan extract pellet and preparation method thereof |
| CN105560603A (en) * | 2014-10-09 | 2016-05-11 | 天津尖峰弗兰德医药科技发展有限公司 | Novel tea polyphenol spherical particles |
| CN108130607A (en) * | 2017-12-29 | 2018-06-08 | 罗莱生活科技股份有限公司 | A kind of pomegranate rind extract powder, granatum regenerated celulose fibre and preparation method thereof |
| CN108149493A (en) * | 2017-12-29 | 2018-06-12 | 罗莱生活科技股份有限公司 | A kind of preparation method of granatum dyestuff and the purposes of granatum dyestuff |
| CN108299845A (en) * | 2017-12-29 | 2018-07-20 | 罗莱生活科技股份有限公司 | A kind of pomegranate husk pigment extracting solution as well as preparation method and application thereof |
-
2018
- 2018-11-15 CN CN201811356850.XA patent/CN109464477A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703546A (en) * | 2009-11-20 | 2010-05-12 | 天津市弗兰德医药科技发展有限公司 | Sanchi extract pellets and preparation method thereof |
| CN102462744A (en) * | 2010-11-19 | 2012-05-23 | 天津尖峰弗兰德医药科技发展有限公司 | Cortex moutan extract pellet and preparation method thereof |
| CN105560603A (en) * | 2014-10-09 | 2016-05-11 | 天津尖峰弗兰德医药科技发展有限公司 | Novel tea polyphenol spherical particles |
| CN108130607A (en) * | 2017-12-29 | 2018-06-08 | 罗莱生活科技股份有限公司 | A kind of pomegranate rind extract powder, granatum regenerated celulose fibre and preparation method thereof |
| CN108149493A (en) * | 2017-12-29 | 2018-06-12 | 罗莱生活科技股份有限公司 | A kind of preparation method of granatum dyestuff and the purposes of granatum dyestuff |
| CN108299845A (en) * | 2017-12-29 | 2018-07-20 | 罗莱生活科技股份有限公司 | A kind of pomegranate husk pigment extracting solution as well as preparation method and application thereof |
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Application publication date: 20190315 |