CN103859384A - Compound grape seed extract pellets and preparation method thereof - Google Patents
Compound grape seed extract pellets and preparation method thereof Download PDFInfo
- Publication number
- CN103859384A CN103859384A CN201210535845.1A CN201210535845A CN103859384A CN 103859384 A CN103859384 A CN 103859384A CN 201210535845 A CN201210535845 A CN 201210535845A CN 103859384 A CN103859384 A CN 103859384A
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- seed extract
- micropill
- grape
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- 238000002360 preparation method Methods 0.000 title claims abstract description 39
- 229940087603 grape seed extract Drugs 0.000 title claims abstract description 34
- 235000002532 grape seed extract Nutrition 0.000 title claims abstract description 34
- 239000001717 vitis vinifera seed extract Substances 0.000 title claims abstract description 34
- 150000001875 compounds Chemical class 0.000 title claims abstract description 19
- 239000008188 pellet Substances 0.000 title claims abstract description 16
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 19
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims abstract description 18
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims abstract description 18
- 239000001751 lycopene Substances 0.000 claims abstract description 18
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims abstract description 18
- 229960004999 lycopene Drugs 0.000 claims abstract description 18
- 235000012661 lycopene Nutrition 0.000 claims abstract description 18
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims description 34
- 239000000203 mixture Substances 0.000 claims description 17
- 239000000853 adhesive Substances 0.000 claims description 9
- 230000001070 adhesive effect Effects 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 8
- 238000009472 formulation Methods 0.000 claims description 7
- 229920002472 Starch Polymers 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 238000005243 fluidization Methods 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 2
- 239000004925 Acrylic resin Substances 0.000 claims description 2
- 229920000178 Acrylic resin Polymers 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 239000001856 Ethyl cellulose Substances 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 235000014633 carbohydrates Nutrition 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 235000010980 cellulose Nutrition 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 235000019441 ethanol Nutrition 0.000 claims description 2
- 229920001249 ethyl cellulose Polymers 0.000 claims description 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 239000000463 material Substances 0.000 abstract description 6
- 238000004090 dissolution Methods 0.000 abstract description 3
- 239000011230 binding agent Substances 0.000 abstract 2
- 239000002245 particle Substances 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 6
- 239000000843 powder Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 239000012530 fluid Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003405 delayed action preparation Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000459479 Capsula Species 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000007922 dissolution test Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229960002179 ephedrine Drugs 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 229940087559 grape seed Drugs 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides a compound grape seed extract pellet preparation, which is prepared from a grape seed extract, lycopene and a pharmaceutical auxiliary material, and is characterized in that the pharmaceutical auxiliary material is an excipient and a binder, wherein the content of the grape seed extract in the pellet preparation is 5-20 wt%, the content of the lycopene in the pellet preparation is 1-5 wt%, the content of the excipient in the pellet preparation is 70-85 wt%, and the content of the binder in the pellet preparation is 1-5 wt%. According to the present invention, the pellet preparation has characteristics of high dissolution rate and high bioavailability, and the preparation method is simple and convenient, and is easy to operate.
Description
Technical field
The present invention relates to medicine food technical field, be specifically related to micropill that a kind of compound grape-seed extract makes and preparation method thereof.
Background technology
The various folk prescription health products of grape seed extract and lycopene are more, but the compound preparation about the two has no report, at present, deeply be subject to consumers in general's approval about the product of grape seed extract and lycopene, these products are except being single preparations of ephedrine, substantially be common Tablet and Capsula agent, but above-mentioned formulation exists disintegration time long; A certain position point disintegration in vivo, has certain excitant to gastric mucosa; The shortcomings such as bioavilability is low.Based on the problems referred to above, we will develop micropill technology transfer rapidly to field of food at field of medicaments, this product made and discharged in vivo compound micro-pill type product controlled and that bioavilability is high, to meet better consumers in general's demand.
In the preparation process of pellet preparations, generally to add the pharmaceutic adjuvants such as excipient, adhesive, pore-foaming agent, disintegrant, plasticizer [" design and development of sustained-release and controlled release preparation " Yan Yaodong etc., Chinese Medicine science and technology publishing house, 2006,257-258], in the research process of micropill, need to carry out deep research to preparation preparation, just can prepare qualified micropill product.
Summary of the invention
The object of the invention is, in order to overcome the problems of the prior art, provides a kind of novel formulation of compound grape-seed extract---pellet preparations.
Another object of the present invention is to provide a kind of preparation method of compound grape-seed extract micropill preparation, the method is simple, convenient, easy operating.
Compound grape-seed extract of the present invention can be extract, can be also active ingredient, prepares according to existing literature method or patented method.
The object of the invention is to be achieved through the following technical solutions:
A kind of compound grape-seed extract micropill preparation, be prepared from by grape seed extract, lycopene, pharmaceutic adjuvant, it is characterized in that pharmaceutic adjuvant is excipient and adhesive, in its pellet preparations, grape seed extract weight percentage is 5～20%, the weight percentage of lycopene is 1～5%, the weight percentage of excipient is 70～85%, and the weight percentage of adhesive is 1～5%.
Slow release formulation prepared by above-mentioned compound grape-seed extract micropill preparation.
Or the enteric formulation prepared of above-mentioned compound grape-seed extract micropill preparation.
Wherein said excipient is one or more the mixture being selected from sucrose, dextrin, starch, microcrystalline cellulose, lactose, methylcellulose, sodium carboxymethylcellulose, polyvinylpyrrolidone, ethyl cellulose, acrylic resin, hydroxypropyl methylcellulose and gelatin.
Wherein said adhesive is one or more the mixture in polyvinylpyrrolidone, cellulose family, resinae, carbohydrate, animal acid.
Pellet preparations of the present invention can, according to technique scheme, be prepared with the preparation method of prior art pellet preparations, also can be prepared by the following method:
(1) get grape seed extract, lycopene, add excipient, be crushed to micronized rank, mix;
(2) by the solution in water-soluble adhesive, absolute ethyl alcohol or hydrous ethanol;
(3) adopt micropill forming technique to make micropill.
Wherein said micropill forming technique comprises that being selected from general ball method, extruding-round as a ball one-tenth ball method or centrifugal-fluidisation makes ball method.
In conventional art, the degree of grinding of medicinal material or extract is meal (inside take, particle diameter 850um ± 70um, cross 24 mesh sieves), middle powder (inside take, particle diameter 250um ± 9.9um, cross 65 mesh sieves), fine powder (wound use, particle diameter 150um ± 6.6um, cross 100 mesh sieves), fine powder (eye droppings use, particle diameter 125um ± 5.8um, 120 mesh sieves) and impalpable powder (particle diameter 75um ± 4.1um, 200 mesh sieves), the present invention adopts micronization technology that compound grape-seed extract is ground into micro mist, its average grain diameter is generally less than 10um, is mainly distributed in 1～20um.Method of micronization can adopt method of the prior art: physical crushing method, such as mechanical impact crusher, airslide disintegrating mill, ball mill, vibromill, stirring mill, Raymond mill, high-pressure pulverizer etc.; Physical chemistry synthetic method, comprising that spraying is dry, original position micronizing and supercritical fluid technique etc.Compared with traditional crushing technology, this technique main advantage is: increase active ingredient absorptivity, improve bioavilability.The dissolution rate of active ingredient is directly proportional to its specific grain surface is long-pending, and specific area and particle diameter are inversely proportional to.Therefore, the particle diameter of active ingredient is thinner, and its specific area is larger, more contributes to the stripping of active ingredient.According to the study, stomach is 15um left and right to the optimal absorption granularity of material grains, and the particle of micron composition has just reached this optimal absorption fineness level; Because micron order active ingredient obviously increases in GI solubility, thereby increase its bioavilability, accelerated its onset time.
Micropill forming technique in the present invention can adopt any micropill forming technique of the prior art, and these technology include but not limited to: general ball method, extruding-round as a ball one-tenth ball method or centrifugal-fluidisation are made ball method etc.
Beneficial effect of the present invention is:
First, grape seed extract, lycopene and excipient have been carried out sufficient pulverizing by we, grape seed extract and lycopene have been distributed in excipient well, and particle diameter has reached micro powder grade, make micropill with such material, in the process discharging in vivo, principal component can discharge rapidly along with the dissolving of excipient, and the every capsules of this product is made up of the little micropill unit of hundreds of grain, disperse in vivo area large, the specific area contacting with gastric juice is also large, admittedly it is rapid to make this product take rear onset, bioavilability is high.
The micropill that micropill of the present invention can be made quick release or be discharged at a slow speed by different prescriptions as required, belongs to multiple agent type, can be made up of the micropill of different drug release rates.Also can pass through packaging technique, micropill is made to the positioned releasing micropills such as stomach dissolution type, enteric solubility.This micropill can encapsulatedly be made capsule, or compressing tablet makes tablet, or makes other various packaged forms.Micropill of the present invention is compared with single dose formulation (as tablet), and supplementary product consumption is few, and steady quality has good curative effect reappearance, and adverse reaction rate is low; This product micropill increases at the area of intestines and stomach surface distributed, bioavilability is improved and local excitation is less or eliminate, and selects for consumers in general provide more consumption.
Meanwhile, we can also, by micropill being carried out to the technology of dressing, by different coating materials, make product become the product of the different sizes such as slowly-releasing, controlled release, enteric.
The consumer who has gastric lesions for some, the impact for fear of product on stomach makes this product be absorbed by the body better simultaneously, and we can also make enteric coated preparations by this product, by micropill is carried out to enteric coated technology, make product reach the object of enteric.This enteric-coated micro-pill is carried out the discovery of release in vitro simulated test by we, micropill in simulated gastric fluid 2 hours without any stripping, outward appearance is also without any variation, and in the time that we are put into its taking-up in simulated intestinal fluid dissolution test, its 30 minutes releases have just reached more than 90%.
The specific embodiment
embodiment 1
Get the raw material for standby of following formula
| Grape seed extract | 15g(is in sterling) |
| Lycopene | 1g |
| Celluloasun Microcrystallisatum | 80g |
| Hydroxypropyl methylcellulose | 4g |
Prepare in accordance with the following methods pellet preparations:
(1) grape seed extract, the lycopene of getting above-mentioned formula ratio add Celluloasun Microcrystallisatum, are crushed to micronizing rank with ball mill, mix;
(2) hydroxypropyl methylcellulose is dissolved in to 75% ethanolic solution;
(3) adopt extruding-round as a ball one-tenth ball method to make micropill.
?
embodiment 2
Get the raw material for standby of following formula
| Grape seed extract | 10g(is in sterling) |
| Lycopene | 3g |
| Starch | 82g |
| Polyvinylpyrrolidone | 5g |
Prepare in accordance with the following methods pellet preparations:
(1) grape seed extract, the lycopene of getting above-mentioned formula ratio add starch, are crushed to micronizing rank with ball mill, mix;
(2) polyvinyl pyrrolidone is soluble in water;
(3) adopt general ball method to make micropill.
embodiment 3
Get the raw material for standby of following formula
| Grape seed extract | 8g(is in sterling) |
| Lycopene | 5g |
| Sucrose | 49g |
| Starch | 34g |
| Polyvinylpyrrolidone | 4g |
Prepare in accordance with the following methods pellet preparations:
(1) grape seed extract, the lycopene of getting above-mentioned formula ratio add sugarcane sugar and starch, are crushed to micronizing rank with ball mill, mix;
(2) polyvinylpyrrolidone is dissolved in suitable quantity of water;
(3) adopt centrifugal-fluidisation to make ball method and make micropill.
Claims (7)
1. a compound grape-seed extract micropill preparation, be prepared from by grape seed extract, lycopene, pharmaceutic adjuvant, it is characterized in that pharmaceutic adjuvant is excipient and adhesive, in its pellet preparations, grape seed extract weight percentage is 5～20%, the weight percentage of lycopene is 1～5%, the weight percentage of excipient is 70～85%, and the weight percentage of adhesive is 1～5%.
2. the slow release formulation that prepared by a kind of compound grape-seed extract micropill preparation according to claim 1.
3. the enteric formulation that prepared by a kind of compound grape-seed extract micropill preparation according to claim 1.
4. a kind of compound grape-seed extract micropill preparation according to claim 1, wherein said excipient is one or more the mixture being selected from sucrose, dextrin, starch, microcrystalline cellulose, lactose, methylcellulose, sodium carboxymethylcellulose, polyvinylpyrrolidone, ethyl cellulose, acrylic resin, hydroxypropyl methylcellulose and gelatin.
5. a kind of compound grape-seed extract micropill preparation according to claim 1, wherein said adhesive is one or more the mixture in polyvinylpyrrolidone, cellulose family, resinae, carbohydrate, animal acid.
6. according to the preparation method of a kind of compound grape-seed extract micropill preparation described in claim 1～5 any one, the steps include:
(1) get grape seed extract, lycopene, add excipient, be crushed to micronized rank, mix;
(2) by the solution of water-soluble adhesive, absolute ethyl alcohol or hydrous ethanol;
(3) adopt micropill forming technique to make micropill.
7. preparation method according to claim 6, wherein said micropill forming technique comprises that being selected from general ball method, extruding-round as a ball one-tenth ball method or centrifugal-fluidisation makes ball method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210535845.1A CN103859384A (en) | 2012-12-13 | 2012-12-13 | Compound grape seed extract pellets and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210535845.1A CN103859384A (en) | 2012-12-13 | 2012-12-13 | Compound grape seed extract pellets and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103859384A true CN103859384A (en) | 2014-06-18 |
Family
ID=50898842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210535845.1A Pending CN103859384A (en) | 2012-12-13 | 2012-12-13 | Compound grape seed extract pellets and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103859384A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106262897A (en) * | 2016-08-17 | 2017-01-04 | 佛山市夕泪饮料有限公司 | A kind of beverage |
-
2012
- 2012-12-13 CN CN201210535845.1A patent/CN103859384A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106262897A (en) * | 2016-08-17 | 2017-01-04 | 佛山市夕泪饮料有限公司 | A kind of beverage |
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Application publication date: 20140618 |