CN101444489A - Astragalus polyose pellet and preparation method thereof - Google Patents
Astragalus polyose pellet and preparation method thereof Download PDFInfo
- Publication number
- CN101444489A CN101444489A CNA2008101828095A CN200810182809A CN101444489A CN 101444489 A CN101444489 A CN 101444489A CN A2008101828095 A CNA2008101828095 A CN A2008101828095A CN 200810182809 A CN200810182809 A CN 200810182809A CN 101444489 A CN101444489 A CN 101444489A
- Authority
- CN
- China
- Prior art keywords
- pellet
- preparation
- astragalus
- astragalus polyose
- excipient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention provides an astragalus polyose pellet preparation composed of astragalus polyose and medical supplementary materials. The astragalus polyose pellet preparation is characterized in that the medical supplementary materials are excipients and binders; and in the pellet preparation, the content of astragalus polyose 0.5-70 percent by weight, the content of excipients is 30-99.5 percent by weight, and the content of binders is 1-5 percent by weight. The pellet preparation has high dissolution rate and high bioavailability, and the preparation method is simple, convenient and easy for operation.
Description
Technical field:
The present invention relates to the medicine food technical field, be specifically related to micropill that a kind of astragalus polysaccharides makes and preparation method thereof.
Background technology:
The Radix Astragali is the dry root of leguminous plant Radix Astagali or Radix Astragali.The Radix Astragali is with a long history simply, and clinical practice is very extensive, is one of successive dynasties traditional Chinese medical science Chinese medicine the most commonly used.In recent years, along with people to the going deep into of STUDY ON POLYSACHAROSE, find that polysaccharide has many-sided biological activity and function.One of the main active of Radix Astragali astragalus polysaccharides is also having stronger activity to receive much concern because of it aspect enhancing human body immunity power, blood sugar lowering, the defying age.
At present, the product of relevant astragalus polysaccharides is subjected to consumers in general's favor deeply.These products are common tablet and capsule substantially, but above-mentioned dosage form exists disintegration time long; A certain position point disintegrate in vivo has certain zest to gastric mucosa; Shortcomings such as bioavailability is low.Based on the problems referred to above, we will develop micropill technology transfer rapidly to field of food at field of medicaments, this product made discharge micro-pill type product controlled and that bioavailability is high in vivo.
Generally to add pharmaceutic adjuvants such as excipient, binding agent, porogen, disintegrating agent, plasticizer [" design and development of sustained-release and controlled release preparation " Yan Yaodong etc. in the preparation process of pellet preparations, Chinese Medicine science and technology publishing house, 2006,257-258], in the research process of micropill, need carry out deep research to formulation preparation, just can prepare qualified micropill product.
Summary of the invention:
For these reasons, we carry out deep analysis by physics and chemical property to astragalus polysaccharides, with the dissolution is index, test by science, determine that pharmaceutic adjuvant is excipient and binding agent, and excipient and binding agent are carried out determining of weight percentage: " pharmaceutic adjuvant is excipient and binding agent; the astragalus polysaccharides weight percentage is 0.5~70% in its pellet preparations; the weight percentage of excipient is 30~99.5%, and the weight percentage of binding agent is 1~5% "; By this complete technical scheme, those skilled in the art just can prepare satisfactory pellet preparations according to the preparation method of the micropill of prior art; Above-mentioned pellet preparations can be prepared into satisfactory slow releasing preparation or enteric coated preparation, help user's compliance.We have carried out sufficient pulverizing with astragalus polysaccharides and excipient, be that micronization is pulverized, make astragalus polysaccharides be distributed in the excipient well, make particle diameter reach micro powder grade, make micropill with such material, in vivo in the process of Shi Fanging, main constituent can discharge rapidly along with the dissolving of excipient, and this product is made up of the little micropill unit of hundreds of grain, disperse area big in vivo, the organ contacted specific surface area is also big with absorbing, so onset is rapid after making this product take, and the bioavailability height.
The objective of the invention is provides a kind of novel formulation of astragalus polysaccharides---pellet preparations in order to overcome the problems of the prior art.
Another object of the present invention is to provide a kind of preparation method of astragalus polyose pellet preparation, this method is simple, convenient, easy operating.
The objective of the invention is to be achieved through the following technical solutions:
A kind of astragalus polyose pellet preparation, be prepared from by astragalus polysaccharides and pharmaceutic adjuvant, it is characterized in that pharmaceutic adjuvant is excipient and binding agent, the astragalus polysaccharides weight percentage is 0.5~70% in its pellet preparations, the weight percentage of excipient is 30~99.5%, and the weight percentage of binding agent is 1~5%.
The slow release formulation of above-mentioned astragalus polyose pellet formulation preparation.
Or the enteric dosage form of above-mentioned astragalus polyose pellet formulation preparation.
Wherein said excipient is one or more the mixture that is selected from sucrose, dextrin, starch, microcrystalline Cellulose, lactose, methylcellulose, sodium carboxymethyl cellulose, polyvinylpyrrolidone, ethyl cellulose, acrylic resin, hydroxypropyl emthylcellulose and the gelatin.
Wherein said binding agent is one or more the mixture in polyvinylpyrrolidone, cellulose family, resinae, saccharide, the animal acid.
Pellet preparations of the present invention can be according to technique scheme, is prepared with the preparation method of prior art pellet preparations, also can be prepared according to following method:
(1) gets astragalus polysaccharides, add excipient, be crushed to micronized rank, mixing;
(2) a kind of in the water-soluble or ethanol with binding agent, or in two kinds of solution that is mixed in proportion;
(3) adopt the micropill forming technique to make micropill.
Wherein said micropill forming technique comprises that being selected from agitation procedure, extruding-round as a ball one-tenth ball method or centrifugal-fluidisation makes the ball method.
In the conventional art, the degree of grinding of medical material or extract is coarse powder (in take, particle diameter 850um ± 70um, cross 24 mesh sieves), middle powder (in take, particle diameter 250um ± 9.9um, cross 65 mesh sieves), fine powder (wound usefulness, particle diameter 150um ± 6.6um, cross 100 mesh sieves), fine powder (eye dripping usefulness, particle diameter 125um ± 5.8um, 120 mesh sieves) and impalpable powder (particle diameter 75um ± 4.1um, 200 mesh sieves), the present invention then adopts micronization technology that astragalus polysaccharides is ground into micropowder, its mean diameter is generally less than 10um, mainly is distributed in 1~20um.Method of micronization can adopt method of the prior art: physical pulverization method, for example mechanical impact crusher, jet mill, ball mill, vibromill, stirring mill, Raymond mill, high-pressure micronizer machine etc.; The physical chemistry synthetic method comprises spray drying, original position micronization and supercritical fluid technology etc.Compare with traditional crushing technology, the main advantage of this technology is: increase the effective ingredient absorbance, improve bioavailability.The dissolution rate of effective ingredient is directly proportional with its specific grain surface is long-pending, and specific surface area and particle diameter are inversely proportional to.Therefore, the particle diameter of effective ingredient is thin more, and then its specific surface area is big more, helps the stripping of effective ingredient more.According to the study, the intestines and stomach is about 15um to the optimal absorption granularity of material grains, and the granule of micron composition has just reached this optimal absorption fineness level; Because the micron order effective ingredient obviously increases at the gastrointestinal dissolubility, thereby increases its bioavailability, has accelerated its onset time.
Micropill forming technique among the present invention can adopt any micropill forming technique of the prior art, and these technology include but not limited to: agitation procedure, extruding-round as a ball one-tenth ball method or centrifugal-fluidisation are made ball method etc.
Beneficial effect of the present invention is:
At first, we have carried out sufficient pulverizing with astragalus polysaccharides and excipient, astragalus polysaccharides has been distributed in the excipient well, and particle diameter have reached micro powder grade, make micropill with such material, in the process of Shi Fanging, main constituent can discharge rapidly along with the dissolving of excipient in vivo, and the every capsules of this product is made up of the little micropill unit of hundreds of grain, disperse area big in vivo, also big with the gastric juice contacted specific surface area, admittedly onset is rapid after making this product take, the bioavailability height.
The micropill that micropill of the present invention can be made rapid release or discharge at a slow speed by different prescriptions as required belongs to multiple agent type, can be made up of the micropill of different drug release rates.Also can pass through packaging technique, micropill be made positioned releasing micropills such as stomach dissolution type, enteric solubility.This micropill can encapsulatedly be made capsule, or tabletting makes tablet, or makes other various packaged forms.Micropill of the present invention is compared with single dose dosage form (as tablet), and supplementary product consumption is few, and steady quality has curative effect repeatability preferably, and adverse reaction rate is low; This product micropill increases at the area of gastrointestinal tract surface distributed, bioavailability is improved and local excitation is less or eliminate, and selects for consumers in general provide more consumption.
We have carried out release in vitro contrast test (experimental technique is according to Pharmacopoeia of People's Republic of China version dissolution in 2005 check and analysis method) with this product and commercially available tablet and conventional capsule agent, and the result is as follows:
The conventional capsule agent (the Xi'an manufacturer production, lot number: 20071214) 30 minutes dissolution rates are 63% in gastric juice;
Tablet (the Shandong manufacturer production, lot number: 080510) 30 minutes dissolution rates are 57% in gastric juice;
And this product 30 minutes dissolution rates in gastric juice promptly reach 90%.
Simultaneously, we can also by different coating materials, make product become the product of different sizes such as slow release, controlled release, enteric by micropill being carried out the technology of coating.
Therefore after we make slow-release micro-pill with this product, have 12 hours slow-release function, can effectively control the burst size of astragalus polysaccharides, safety, effectiveness are better; Slow-release micro-pill can make blood drug level reach curative effect concentration rapidly, and keeps steady, long valid density, and blood concentration fluctuation is little; This product has reduced the accumulated dose of taking than common dosage form simultaneously, has reduced the number of times of taking of consumer.We find that by the release in vitro simulation test its release profiles is obvious with this product, and when 2h, release is more than 30%; During 5h, release is more than 50%; During 8h, release is more than 75%; During 12h, release is more than 90%.
Have the consumer of stomach illness for some, for fear of the influence of product to stomach, this product is absorbed by the body better, we can also make enteric coated preparation with this product, promptly by micropill is carried out enteric coated technology, make product reach the purpose of enteric.We carry out the release in vitro simulation test with this enteric coated micropill and find, micropill in simulated gastric fluid 2 hours without any stripping, outward appearance is also without any variation, and when we were put into its taking-up in the simulated intestinal fluid dissolution test, its 25 minutes releases had just reached more than 85%.
The specific embodiment
Embodiment 1
Get the raw material for standby of following prescription
Astragalus polysaccharides | 5g |
Starch | 91.5g |
Hydroxypropyl emthylcellulose | 3.5g |
Prepare pellet preparations in accordance with the following methods:
(1) astragalus polysaccharides of getting above-mentioned formula ratio adds starch, is crushed to micronization rank, mixing with ball mill;
(2) hydroxypropyl emthylcellulose is dissolved in 75% alcoholic solution;
(3) adopt extruding-round as a ball one-tenth ball method to make micropill.
Embodiment 2
Get the raw material for standby of following prescription
Astragalus polysaccharides | 20g |
Starch | 75g |
Polyvinylpyrrolidone | 5g |
Prepare pellet preparations in accordance with the following methods:
(1) astragalus polysaccharides of getting above-mentioned formula ratio adds starch, is crushed to micronization rank, mixing with ball mill;
(2) polyvinyl pyrrolidone is soluble in water;
(3) adopt agitation procedure to make micropill.
Embodiment 3
Get the raw material for standby of following prescription
Astragalus polysaccharides | 50g |
Celluloasun Microcrystallisatum | 46.5g |
Hydroxypropyl emthylcellulose | 3.5g |
Prepare pellet preparations in accordance with the following methods:
(1) astragalus polysaccharides of getting above-mentioned formula ratio adds Celluloasun Microcrystallisatum, is crushed to micronization rank, mixing with ball mill;
(2) hydroxypropyl emthylcellulose is dissolved in an amount of 70% ethanol;
(3) adopt centrifugal-fluidisation to make the ball method and make micropill.
Claims (7)
1. astragalus polyose pellet preparation, be prepared from by astragalus polysaccharides and pharmaceutic adjuvant, it is characterized in that pharmaceutic adjuvant is excipient and binding agent, the astragalus polysaccharides weight percentage is 0.5~70% in its pellet preparations, the weight percentage of excipient is 30~99.5%, and the weight percentage of binding agent is 1~5%.
2. the slow release formulation of a kind of astragalus polyose pellet formulation preparation according to claim 1.
3. the enteric dosage form of a kind of astragalus polyose pellet formulation preparation according to claim 1.
4. a kind of astragalus polyose pellet preparation according to claim 1, wherein said excipient are one or more the mixture that is selected from sucrose, dextrin, starch, microcrystalline Cellulose, lactose, methylcellulose, sodium carboxymethyl cellulose, polyvinylpyrrolidone, ethyl cellulose, acrylic resin, hydroxypropyl emthylcellulose and the gelatin.
5. a kind of astragalus polyose pellet preparation according to claim 1, wherein said binding agent are one or more the mixture in polyvinylpyrrolidone, cellulose family, resinae, saccharide, the animal acid.
6. each described a kind of preparation method of astragalus polyose pellet preparation of claim 1~5 the steps include:
(1) gets astragalus polysaccharides, add excipient, be crushed to micronized rank, mixing;
(2) in the solution of binding agent is water-soluble, dehydrated alcohol or aquiferous ethanol;
(3) adopt the micropill forming technique to make micropill.
7. preparation method according to claim 6, wherein said micropill forming technique comprise agitation procedure, method of extruding and kneading to pellets or the centrifugal fluidized granulation method of being selected from.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNA2008101828095A CN101444489A (en) | 2008-12-09 | 2008-12-09 | Astragalus polyose pellet and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNA2008101828095A CN101444489A (en) | 2008-12-09 | 2008-12-09 | Astragalus polyose pellet and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN101444489A true CN101444489A (en) | 2009-06-03 |
Family
ID=40740570
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2008101828095A Pending CN101444489A (en) | 2008-12-09 | 2008-12-09 | Astragalus polyose pellet and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101444489A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104382925A (en) * | 2014-10-10 | 2015-03-04 | 佳木斯大学 | Nanometer composite polysaccharide colon-targeting pellets and manufacturing method thereof |
CN108451926A (en) * | 2018-04-28 | 2018-08-28 | 四川国康药业有限公司 | A kind of Radix Astragali pellet and preparation method thereof for invigorating qi for strengthening superficies |
CN110604769A (en) * | 2018-06-17 | 2019-12-24 | 罗建平 | Multifunctional composite plant polysaccharide |
-
2008
- 2008-12-09 CN CNA2008101828095A patent/CN101444489A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104382925A (en) * | 2014-10-10 | 2015-03-04 | 佳木斯大学 | Nanometer composite polysaccharide colon-targeting pellets and manufacturing method thereof |
CN108451926A (en) * | 2018-04-28 | 2018-08-28 | 四川国康药业有限公司 | A kind of Radix Astragali pellet and preparation method thereof for invigorating qi for strengthening superficies |
CN110604769A (en) * | 2018-06-17 | 2019-12-24 | 罗建平 | Multifunctional composite plant polysaccharide |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101703479A (en) | Resveratrol pellet and preparation method thereof | |
CN101703540A (en) | Celeryseed extract pellets and preparation method thereof | |
CN101444489A (en) | Astragalus polyose pellet and preparation method thereof | |
CN101444558A (en) | Desertliving cistanche herb extract pellet and preparation method thereof | |
CN101703475A (en) | Chondroitin sulfate pellet and preparation method thereof | |
CN101214322A (en) | Grape seed extract micropills and preparation thereof | |
CN102462722A (en) | Honeysuckle extract pellet and preparation method thereof | |
CN101703478A (en) | Zinc gluconate pellets and preparation method thereof | |
CN101703532A (en) | Ganoderan polysaccharide pellet and preparation method thereof | |
CN101219126A (en) | Beta-carotene pellet and method for preparing the same | |
CN101455679A (en) | Donkey-hide gelatin micro-pills and preparation method thereof | |
CN103845293A (en) | Lutein pellet and preparation method thereof | |
CN101214236A (en) | Soybean isoflavone micropills and preparation thereof | |
CN102462717A (en) | American ginseng extract pellet and preparation method thereof | |
CN102462721A (en) | Dangshen extract pellet and preparation method thereof | |
CN101219123A (en) | Tea polyphenol pellet and method for preparing the same | |
CN101444547A (en) | Sea buckthorn extract pellet and preparation method thereof | |
CN101444487A (en) | Vitamin E micropill and preparation method thereof | |
CN101703476A (en) | Zeaxanthin pellets and preparation method thereof | |
CN101214231A (en) | Lycopene micropills and preparation thereof | |
CN101703529A (en) | Cordyceps mycelia polysaccharide pellet and preparation method thereof | |
CN101703477A (en) | Coenzyme Q10 mini-pill and preparation method thereof | |
CN101444544A (en) | Folium ginkgo extract micropill and preparation method thereof | |
CN101455837A (en) | Collagen protein micro-pill and preparation method thereof | |
CN101214232A (en) | Lutein micropills and preparation thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090603 |