CN109453363A - Alleviate stomachache gastric acid, composition of antidiarrheal defaecation and its preparation method and application - Google Patents
Alleviate stomachache gastric acid, composition of antidiarrheal defaecation and its preparation method and application Download PDFInfo
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- CN109453363A CN109453363A CN201811364480.4A CN201811364480A CN109453363A CN 109453363 A CN109453363 A CN 109453363A CN 201811364480 A CN201811364480 A CN 201811364480A CN 109453363 A CN109453363 A CN 109453363A
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- antidiarrheal
- defaecation
- composition
- gastric acid
- stomachache
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Abstract
The present invention provides a kind of alleviation stomachache gastric acids, the composition of antidiarrheal defaecation and its preparation method and application.Wherein, the alleviation stomachache gastric acid, antidiarrheal defaecation composition, the raw material including following mass fraction: 0.1 part~10 parts Lactobacillus rhamnosus, 0.1 part~5 parts bifidobacterium lactis and 15 parts~45 portions soybean proteins.Above-mentioned alleviation stomachache gastric acid, the composition each group distribution ratio of antidiarrheal defaecation are reasonable, the optimal efficacy of composition can be played, there are prevention and/or treatment to stomachache, regurgitation of gastric juice, constipation and diarrhea, in addition, alleviating stomachache gastric acid, the composition of antidiarrheal defaecation also has both preferable taste flavor.
Description
Technical field
The present invention relates to a kind of alleviation stomachache gastric acids, the composition of antidiarrheal defaecation and its preparation method and application.
Background technique
The disease incidence of present enterogastric diseases is higher and higher, with people's the accelerating rhythm of life and life pattern change not
It is irrelevant.It celebrates a festival whenever the New Year, also welcomes the gastrointestinal disease high-incidence season simultaneously, mainly all kinds of dinner party wine office, greasy diet during the vacation
And irregular work and rest causes, this is also the concentrated reflection of present city people unhealthy diet and living habit on ordinary days.
Count according to World Health Organization's stomach trouble situation of fourth quarter in 2005: atrophic gastritis, gastric ulcer, duodenum are burst
The gastrointestinal tracts persistent ailments such as ulcer, colitis, stomach malignancy, intestines malignant tumour are just in steeply rise trend at present.Moreover, people couple
The attention degree of stomach health far away from heart, liver, kidney health, or even there are about half patients to be not aware that oneself with stomach
Disease.Chinese healthy white paper in 2007 but shows that Chinese stomach patient has 1.2 hundred million people, peptic ulcer rate 10%,
Chronic gastritis disease incidence 30% is that the whole world is undisputed " stomach trouble big country ".Then, a to be directed to 22152 young people
The survey report of group's stomach trouble health gives more intuitive concept: 65.55% interviewee explicitly indicates that with stomach trouble,
Whether 22.18% people does not know oneself stomach trouble, and only 12.27% people affirms that oneself does not have stomach trouble；In disease of having a stomach upset
In shape, the puzzlement such as 36.74% interviewee will receive abdominal distension, nausea, keck, 36.27% interviewee has a stomachache, 28.58% by
Visit person will appear sour regurgitation or the heartburn symptom of stomach.
Currently, the major product of enterogastritis is antibiotic, and the abuse of antibiotic not only considerably reduces stomach and is immunized
Power also expedites the emergence of out more obstinate drug-fast bacteria, is unfavorable for the rehabilitation of enterogastritis.In addition, enterogastritis is more to be accompanied by constipation and abdomen
It rushes down.Therefore, develop a kind of new product for enterogastritis very it is necessary to.
Summary of the invention
Based on this, it is necessary to provide a kind of composition that can alleviate stomachache gastric acid, antidiarrheal defaecation.
In addition, also providing a kind of preparation method and application that can alleviate gastric acid of having a stomachache, the composition of antidiarrheal defaecation.
A kind of composition for alleviating stomachache gastric acid, antidiarrheal defaecation, in terms of mass fraction, alleviation the stomachache gastric acid, antidiarrheal
The raw material of the composition of defaecation includes:
0.1 part~10 parts of Lactobacillus rhamnosus；
0.1 part~5 parts of bifidobacterium lactis；And
15 parts~45 parts of soybean protein.
Above-mentioned alleviation stomachache gastric acid, the composition each group distribution ratio of antidiarrheal defaecation are reasonable, can play the best of composition
Effect plays the role of prevention and/or treatment to stomachache, regurgitation of gastric juice.In addition, alleviating the composition of stomachache gastric acid, antidiarrheal defaecation
Also play the role of significantly preventing and/or treating to diarrhea and constipation.
In one of the embodiments, in terms of mass fraction, the original for alleviating gastric acid of having a stomachache, the composition of antidiarrheal defaecation
Material further includes prebiotics, and the number of the prebiotics is 0.06 part~30 parts.
In one of the embodiments, in terms of mass fraction, the original for alleviating gastric acid of having a stomachache, the composition of antidiarrheal defaecation
Material includes:
In one of the embodiments, the prebiotics in oligofructose, resistant dextrin and lactitol at least one
Kind.
The prebiotics are the mixture of oligofructose, resistant dextrin and lactitol in one of the embodiments,
In, in terms of mass fraction, the oligofructose is 0.5 part~3 parts, and the resistant dextrin is 0.06 part~24 parts, the lactose
Alcohol is 0.5 part~3 parts.
In one of the embodiments, in terms of mass fraction, the original for alleviating gastric acid of having a stomachache, the composition of antidiarrheal defaecation
Material includes 30 parts~70 parts of at least one of xylitol, 3 parts~15 portions sweet oranges and 0.5 part~10 portions of Siraitia grosvenorii.
The viable count contained in the Lactobacillus rhamnosus in one of the embodiments, is 1.0 × 1010CFU/g~5.0
×1011CFU/g, the viable count contained in the bifidobacterium lactis are 1.0 × 1010CFU/g~5.0 × 1011CFU/g。
Above-mentioned alleviation stomachache gastric acid, antidiarrheal defaecation composition preparation method, comprising the following steps:
The raw material of above-mentioned alleviation stomachache gastric acid, the composition of antidiarrheal defaecation is uniformly mixed, the alleviation stomachache stomach is obtained
Sour, antidiarrheal defaecation composition.
Above-mentioned alleviation stomachache gastric acid, antidiarrheal defaecation composition prepare food or preparation to alleviate stomachache gastric acid, antidiarrheal logical
Just the application in drug.
A kind of food, composition and food additives including above-mentioned alleviation stomachache gastric acid, antidiarrheal defaecation.
A kind of drug, composition and pharmaceutically acceptable auxiliary material including above-mentioned alleviation stomachache gastric acid, antidiarrheal defaecation.
Specific embodiment
In order to make the foregoing objectives, features and advantages of the present invention clearer and more comprehensible, below in conjunction with specific embodiment,
The present invention will be described in further detail.It should be appreciated that the specific embodiments described herein are only used to explain this hair
It is bright, it is not intended to limit the present invention.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.
Raw materials used and reagent is commercially available common raw material and reagent unless otherwise specified in following embodiment.
The composition for alleviating stomachache gastric acid, antidiarrheal defaecation of one embodiment, it is described slow in terms of mass fraction
Solve gastric acid of having a stomachache, the raw material of the composition of antidiarrheal defaecation includes:
0.1 part~10 parts of Lactobacillus rhamnosus；
0.1 part~5 parts of bifidobacterium lactis；And
15 parts~45 parts of soyabean protein powder.
The viable count contained in Lactobacillus rhamnosus in one of the embodiments, is 1.0 × 1010CFU/g~5.0 ×
1011CFU/g.Lactobacillus rhamnosus is selected from least one of Lactobacillus rhamnosus GG and Lactobacillus rhamnosus HN001.Rhamnose
Lactobacillus is the mixture of Lactobacillus rhamnosus GG and Lactobacillus rhamnosus HN001.Preferably, Lactobacillus rhamnosus GG and sandlwood
The mass ratio of sugared lactobacillus HN001 is 9:1,10:1 or 11:1.Lactobacillus rhamnosus GG, Lactobacillus rhamnosus HN001 and cream are double
The mixing of discrimination bacillus, three cooperate, and are more advantageous to and maintain intestinal microecology balance, thus antidiarrheal defaecation.
The number of Lactobacillus rhamnosus is 1.5 parts~7 parts in one of the embodiments,.Further, rhamnose cream bar
The number of bacterium is 2 parts, 3 parts, 4 parts or 5 parts.Preferably, the number of Lactobacillus rhamnosus is 1.5 parts~4 parts.
The viable count contained in bifidobacterium lactis in one of the embodiments, is 1.0 × 1010CFU/g~5.0 ×
1011CFU/g.Further, the viable count contained in bifidobacterium lactis is 6.0 × 109CFU/g~3.0 × 1011CFU/g.More into
One step, the viable count contained in bifidobacterium lactis is 8.0 × 108CFU/g~1.0 × 1010CFU/g。
The number of bifidobacterium lactis is 0.2 part~2.5 parts in one of the embodiments,.Further, bifidobacterium lactis
Number be 0.2 part, 0.5 part, 0.8 part or 1.5 parts.Preferably, the number of bifidobacterium lactis is 0.2 part~2 parts.
The number of Lactobacillus rhamnosus is 1.5 parts~4 parts in one of the embodiments, and the number of bifidobacterium lactis is
0.2 part~2 parts.
The viable count of Lactobacillus rhamnosus is 1.0 × 10 in one of the embodiments,10CFU/g~5.0 × 1011CFU/
G, the viable count of bifidobacterium lactis are 1.0 × 1010CFU/g~5.0 × 1011CFU/g.It is more advantageous to the two and plays the best use,
Inhibit enteric bacterial pathogens growth, protection gut barrier and antidiarrheal defaecation.
The viable count of Lactobacillus rhamnosus is 6.0 × 10 in one of the embodiments,9CFU/g~4.5 × 1011CFU/
G, the viable count of bifidobacterium lactis are 6.0 × 109CFU/g~3.0 × 1011CFU/g.It is more advantageous to the two and plays the best use,
Inhibit enteric bacterial pathogens growth, protection gut barrier and antidiarrheal defaecation.
In the present embodiment, soybean protein is soyabean protein powder.The number of soybean protein is 20 parts~40 parts.Further
Ground, the number of soybean protein are 25 parts, 30 parts, 35 parts or 40 parts.Preferably, the number of soybean protein is 25 parts~40 parts.When
So, it is to be understood that the state of soybean protein is not limited to powdery, can be with other forms, such as granular soybean protein.
The number of prebiotics is 0.06 part~30 parts in one of the embodiments,.Further, the number of prebiotics is
0.067 part, 0.5 part, 3 parts, 10 parts or 24 parts.Preferably, the number of prebiotics is 0.06 part~10 parts.
Prebiotics are selected from least one of oligofructose, resistant dextrin and lactitol in one of the embodiments,.Into one
Step ground, prebiotics are the mixture of oligofructose, resistant dextrin and lactitol.The mixture, which is more advantageous to, adjusts intestinal flora
Balanced growth and for Lactobacillus rhamnosus, bifidobacterium lactis people it is intracorporal breeding nutrition is provided.Preferably, oligofructose is
0.5 part~3 parts, resistant dextrin is 0.067 part~24 parts, and lactitol is 0.5 part~3 parts.Further, the oligofructose
It is 0.8 part~3 parts, resistant dextrin is 0.067 part~20 parts, and lactitol is 0.5 part~2.5 parts.In another embodiment, low
Fructooligosaccharides is 1 part, 1.5 parts or 2.5 parts, and resistant dextrin is 0.067 part, 10 parts or 18 parts, and lactitol is 1 part, 1.5 parts or 2 parts.
In one of the embodiments, in terms of mass fraction, above-mentioned alleviation stomachache gastric acid, antidiarrheal defaecation group
Close object raw material include:
Wherein, the viable count of Lactobacillus rhamnosus is 1.0 × 1010CFU/g~5.0 × 1011CFU/g, bifidobacterium lactis
Viable count is 1.0 × 1010CFU/g~5.0 × 1011CFU/g。
In one of the embodiments, in terms of mass fraction, above-mentioned alleviation stomachache gastric acid, antidiarrheal defaecation group
Close object raw material include:
Wherein, the viable count of Lactobacillus rhamnosus is 6.0 × 109CFU/g~4.5 × 1011CFU/g, bifidobacterium lactis
Viable count is 6.0 × 1010CFU/g~3.0 × 1011CFU/g。
In one of the embodiments, in terms of mass fraction, above-mentioned alleviation stomachache gastric acid, antidiarrheal defaecation composition original
Material further includes at least one of 30 parts~70 parts xylitol, 3 parts~15 portions sweet oranges and 0.5 part~10 portions of Siraitia grosvenoriis.At this
In embodiment, sweet orange is sweet orange juice powder, Siraitia grosvenorii be mangosteen powder further, above-mentioned alleviation is had a stomachache gastric acid, antidiarrheal defaecation
The raw material of composition further include 35 parts~68 parts of xylitol, 3.5 parts~12 parts sweet orange juice powder and 0.8 part~5 portions Siraitia grosvenoriis
Powder.Preferably, the number of xylitol is 40 parts~65 parts, and the number of sweet orange juice powder is 4 parts~9 parts, and the number of mangosteen powder is 1
Part~4 parts.
In one of the embodiments, in terms of mass fraction, above-mentioned alleviation stomachache gastric acid, antidiarrheal defaecation composition original
Material includes:
Wherein, the viable count of Lactobacillus rhamnosus is 1.0 × 1010CFU/g~5.0 × 1011CFU/g, bifidobacterium lactis
Viable count is 1.0 × 1010CFU/g~5.0 × 1011CFU/g。
In one of the embodiments, in terms of mass fraction, above-mentioned alleviation stomachache gastric acid, antidiarrheal defaecation composition original
Material includes:
Wherein, the viable count of Lactobacillus rhamnosus is 6.0 × 109CFU/g~4.5 × 1011CFU/g, bifidobacterium lactis
Viable count is 6.0 × 1010~3.0 × 1011CFU/g。
In one of the embodiments, in terms of mass fraction, above-mentioned alleviation stomachache gastric acid, antidiarrheal defaecation composition original
Material includes:
It should be noted that the mass fraction of soybean protein, sweet orange and Siraitia grosvenorii refers to dried product in above-mentioned raw materials
Mass fraction, certainly, in some embodiments, fresh feed also can be used in above-mentioned raw materials, and (i.e. water content is not higher, abundant
Drying raw material), as long as the parts by weight after guarantee is drying are the above-mentioned number enumerated.
Above-mentioned alleviation stomachache gastric acid, antidiarrheal defaecation composition each group distribution ratio it is reasonable, composition can be played most
Good effect plays the role of prevention and/or treatment to stomachache, regurgitation of gastric juice, in addition, alleviating the combination of stomachache gastric acid, antidiarrheal defaecation
Object also plays the role of significantly preventing and/or treating to constipation diarrhea.
A kind of preparation method for alleviating gastric acid of having a stomachache, the composition of antidiarrheal defaecation, comprising the following steps:
By above-mentioned alleviation have a stomachache gastric acid, antidiarrheal defaecation the raw material of composition be uniformly mixed, be eased the gastric acid, only of having a stomachache
Rush down the composition of defaecation.Specifically, including following operation:
S1, each raw material is taken according to corresponding mass fraction.
S2, other each raw materials in addition to Lactobacillus rhamnosus and bifidobacterium lactis are sieved respectively obtains screening object.At it
In middle one embodiment, screening object is the combination of soyabean protein powder and prebiotics.In another embodiment, screening object is soybean
The combination of albumen powder, prebiotics, xylitol, sweet orange juice powder and mangosteen powder.
S3, object and Lactobacillus rhamnosus and bifidobacterium lactis mixing will be screened.
30 mesh~100 meshes are crossed in one of the embodiments, intercept partial size less than 30 mesh~100 mesh screening object.It is excellent
Selection of land, sieving referred to 40 mesh~80 meshes, intercepted partial size less than 40 mesh~80 mesh screening object.Such benefit is made containing multiple
The composition for closing lactic acid bacteria is fine and smooth uniformly, and mouthfeel is more excellent.
In one of the embodiments, before sieving, further including will its in addition to Lactobacillus rhamnosus and bifidobacterium lactis
His each raw material is dry at 30 DEG C~100 DEG C, until the mass percentage of the moisture in each raw material is lower than 7%.Further,
Drying temperature is 40 DEG C~80 DEG C, and dry moisture is until the mass percentage of the moisture in each raw material is lower than 5%.
Above-mentioned alleviation stomachache gastric acid, antidiarrheal defaecation composition preparation method it is simple, it is easy to operate, be suitble to industry metaplasia
It produces.
Above-mentioned alleviation stomachache gastric acid, antidiarrheal defaecation composition prepare food or preparation to alleviate stomachache gastric acid, antidiarrheal logical
Just the application in drug.
A kind of food, including above-mentioned alleviation stomachache gastric acid, antidiarrheal defaecation composition and food on acceptable auxiliary material.
Acceptable auxiliary material is food additives on food in one of the embodiments, such as sweetener is anti-oxidant
Agent.
The type of above-mentioned food is lozenge, chewable tablets or solid beverage in one of the embodiments,.
Lozenge, chewable tablets or solid beverage are prepared into using common process known to those skilled in the art, herein no longer
It repeats.
Above-mentioned food has the function of preventing and treating stomachache, regurgitation of gastric juice.In addition, above-mentioned food is also to constipation and diarrhea
Play the role of significantly preventing and treating.
Above-mentioned alleviation stomachache gastric acid, antidiarrheal defaecation composition preparation for prevent and/or treat alleviate stomachache gastric acid,
Application in the drug of antidiarrheal defaecation.
A kind of drug, composition and pharmaceutically acceptable auxiliary material including above-mentioned alleviation stomachache gastric acid, antidiarrheal defaecation.On
Prevention and/or treatment stomachache, regurgitation of gastric juice, diarrhea constipation can be played the role of by stating drug.
Embodiment
It is described in detail below with reference to specific embodiment.Following embodiment unless otherwise specified, is not then contained except not
Other components not yet explicitly pointed out other than evitable impurity.
(1) the alleviation stomachache gastric acid of Examples 1 to 3, the combination of antidiarrheal defaecation are weighed respectively according to the mass fraction in table 1
The raw material of object.
Table 1
(2) then by the raw material in addition to Lactobacillus rhamnosus, bifidobacterium lactis of each embodiment respectively under the conditions of 60 DEG C
It is dry to be lower than 5% to its moisture content, it crosses 80 meshes and obtains screening object, it then will screening object and Lactobacillus rhamnosus, newborn bifid
Bacillus mixes, and the alleviation stomachache gastric acid of each embodiment, the composition of antidiarrheal defaecation is finally prepared.
Comparative example
The alleviation stomachache gastric acid of comparative example 1~3, the composition of antidiarrheal defaecation are weighed respectively according to the mass fraction in table 2
Raw material:
Table 2
| Comparative example 1 | Comparative example 2 | Comparative example 3 | |
| Lactobacillus rhamnosus | 0 | 0 | 10 |
| Bifidobacterium lactis | 0 | 0 | 10 |
| Soyabean protein powder | 15 | 34 | 10 |
| Resistant dextrin | 25 | 6 | 47 |
| Oligofructose | 1 | 1 | 1 |
| Lactitol | 1 | 1 | 1 |
| Xylitol | 49 | 49 | 19 |
| Sweet orange juice powder | 8 | 8 | 2 |
| Mangosteen powder | 1 | 1 | 0 |
(2) then the above-mentioned raw material in addition to Lactobacillus rhamnosus and bifidobacterium lactis is dried extremely under the conditions of 60 DEG C respectively
Its moisture content is lower than 5%, crosses 60 meshes and obtains screening object.It then will screening object and Lactobacillus rhamnosus and bifidobacterium lactis
(herein referring to comparative example 3 has the case where both bacterium；The screening object of comparative example 1 and comparative example 2 is its corresponding alleviation stomachache stomach
Sour, antidiarrheal defaecation composition) it mixes, obtain the alleviation stomachache gastric acid of each comparative example, the composition of antidiarrheal defaecation.
Effect assessment
Alleviate stomachache gastric acid, antidiarrheal defaecation composition to the intervention effect of diarrhea
(1) Subject Population is grouped
The crowd for having symptom of diarrhea for 18 years old to 65 years old is chosen, Subject Population is randomly divided into blank group, control group, experiment
Group, every group is randomly assigned subject 10.Blank group is not dealt with；Control group is daily to placebo (cellulose).Experimental group
For the composition of alleviation stomachache gastric acid, antidiarrheal defaecation in Examples 1 to 3 and comparative example 1~3, everyone takes 2g daily, continuously
It takes 30 days.
(2) Subject Population's Incidence of Diarrhea and duration measurement
Subject is required to record Incidence of Diarrhea weekly and the weekly duration of diarrhea in 30 days.Subject
The statistical result of Incidence of Diarrhea weekly and the weekly duration of diarrhea are as shown in table 3.
Table 3
As shown in Table 3, subject of the embodiment 1 into embodiment 3 Incidence of Diarrhea weekly and diarrhea is held weekly
The continuous time than comparative example 1 to 3 groups of comparative example it is low with control group.Wherein, the numerical value in embodiment 2 is even more and presents to show with control group
It writes difference (P < 0.05), diarrhea is effectively relieved.
Alleviate stomachache gastric acid, the composition of antidiarrheal defaecation divides intervention effect (1) Subject Population of the symptoms such as stomachache, gastric acid
Group
Choose the crowd for there are the symptoms such as stomachache, stomach are heartburn, appetite is low, nauseous, regurgitation of gastric juice and vomiting for 18 years old to 65 years old
As subject.Subject Population is randomly divided into blank group, control group, experimental group.Blank group and every group of control group are randomly assigned
Subject 20；Every group of experimental group is randomly assigned subject 50.Blank group is not dealt with；Control group is daily to placebo
(cellulose).Experimental group is the composition for alleviating stomachache gastric acid, antidiarrheal defaecation in embodiment 1-3 and comparative example 1-3.It is every daily
People takes 2g, continuously takes 30 days.
(2) Subject Population's stomachache, gastric ulcer measurement
Record subject take for the first time alleviate stomachache gastric acid, antidiarrheal defaecation composition when situation with understand alleviate stomachache stomach
Acid, antidiarrheal defaecation composition to the effect of short-term stomach pain symptom, specifically, when Subject Population has pain symptom
(that is to say 0 minute in table 4) gives the composition taken and alleviate stomachache gastric acid, antidiarrheal defaecation, and after being separately recorded in and taking
5 minutes, 10 minutes, greater than 15 minutes when stomach pain symptom situation；Then everyone takes 2g daily, continuously takes 30 days,
And the case where recording chronic ulcer, loss of appetite, stomachache, symptoms of emesis after 30 days
The percentage that the short-term stomach pain symptom of subject occurs is as shown in table 4, subject's chronic ulcer, loss of appetite,
The percentage that stomachache, symptoms of emesis occur is as shown in table 5.
Table 4
Table 5
By table 4 and 5 it is found that the case where short-term stomach pain symptom of subject of the embodiment 1 into embodiment 3 occurs,
Long-term chronic ulcer, loss of appetite, stomachache, vomiting symptom there is the percent value of situation than comparative example 1, comparative example 2, right
Ratio 3 is low with control group.Wherein, the measured value of embodiment 2 is even more that significant difference (P < 0.05) is presented with control group.Take reality
Apply alleviation stomachache gastric acid of the example 1 into embodiment 3, stomach pain occurs in short term in the subject of composition of antidiarrheal defaecation, and long
Phase occur chronic ulcer, loss of appetite, stomachache, vomit situation percentage reduce, can effectively mitigate stomachache, chronic gastric ulcer with
And the symptoms such as adjoint long-term loss of appetite, stomachache, vomiting.
Alleviate stomachache gastric acid, antidiarrheal defaecation composition to the intervention effect of constipation
(1) Subject Population is grouped
The crowd for having constipation symptom for 18 years old to 65 years old is chosen, Subject Population is randomly divided into blank group, control group, experiment
Group, every group is randomly assigned subject 20.Blank group is not dealt with；Control group is daily to placebo (cellulose).Experimental group
For the composition of alleviation stomachache gastric acid, antidiarrheal defaecation in embodiment 1-3 and comparative example 1-3.Everyone takes 2g daily, continuous to take
With 30 days.
(2) Subject Population's constipation symptom is assessed according to ROMA III
Subject is required the case where recording following index in 30 days: defecation feels arduously, defecation be dry bulb shape just or
Firmly just, defecation has to be felt not to the utmost, and defecation has anorectal obstruction sense/obstruction sense, and defecation needs gimmick to help (such as to be arranged with finger help
Just, basin bottom is supported), defecation frequency.Standards of grading are as follows: never or seldom (0 point), sometimes (1 point), frequent (2 points), when most of
It waits (3 points), always (4 points).
Subject's constipation scoring is as shown in table 6.
Table 6
As shown in Table 6, subject of the embodiment 1 into embodiment 3 " defecation feels arduously, defecation be dry bulb shape just or
Firmly just scoring " is lower with control group than comparative example 1, comparative example 2, comparative example 3；Subject of the embodiment 1 into embodiment 3
Defecation frequency is higher than comparative example 1, comparative example 2, comparative example 3 and control group.Wherein, the measured value of embodiment 2 is even more and compares
Significant difference (P < 0.05) is presented in group.It can be seen that it is logical to take alleviation stomachache gastric acid of the embodiment 1 into embodiment 3, antidiarrheal
Just subject's defecation effort of composition, defecation degree of drying decrease, and defecation frequency improves, and can effectively mitigate row
Just feel laborious, defecation be dry bulb shape just or firmly just, the symptoms such as stool interval is low.
Alleviate gastric acid of having a stomachache, the flavor taste test of the composition of antidiarrheal defaecation
(1) Subject Population is grouped
60 volunteers are chosen, alleviate gastric acid of having a stomachache, the group of antidiarrheal defaecation to 6 kinds of Examples 1 to 3 and comparative example 1~3
It closes object and carries out mouthfeel evaluation, the standard of being included in is the normal adults of no any prescription drug.Exclusion criteria is smoker, whole body
Property disease, be used for a long time antibiotic.The packaging of probiotic composition is consistent, and weight is consistent, and appearance is without significant difference.Using sense organ
Standards of grading evaluate mouthfeel.
Test group is divided into 6 groups: embodiment 1, embodiment 2, embodiment 3, comparative example 1, comparative example 2, comparative example 3 is respectively adopted
Alleviation stomachache gastric acid, antidiarrheal defaecation composition, directly take orally, dose 2g；
(2) sensory evaluation standards of grading
3 indexs: product color, physics (tissue) form, whole mouthfeel are included in sensory evaluation in total.Color from impurity compared with
More to uniform color, scoring is 0 to 10；Physics (tissue) form is agglomerated from silty to silty exquisiteness, and scoring is 0~10；It is whole
For mouthfeel from tasting bad to being fond of eating, scoring is 0 to 10.
(3) result: after the crowd of participation carries out sensory evaluation, the scores of sample are as shown in table 7.
Table 7
| Group | n | Color | Tissue morphology | Whole mouthfeel |
| Embodiment 1 | 10 | 8.3±0.4 | 8.6±0.1 | 8.2±0.9 |
| Embodiment 2 | 10 | 9.4±0.5 | 9.2±0.2 | 9.2±0.8 |
| Embodiment 3 | 10 | 8.4±0.5 | 8.2±0.1 | 7.6±0.7 |
| Comparative example 1 | 10 | 7.1±0.6 | 7.2±0.1 | 6.1±0.8 |
| Comparative example 2 | 10 | 7.4±0.5 | 7.6±0.2 | 6.7±0.8 |
| Comparative example 3 | 10 | 7.3±0.4 | 7.4±0.1 | 5.9±0.9 |
As shown in Table 7, subject of the embodiment 1 into embodiment 3 is for the scoring of flavor taste than comparative example 1, right
Ratio 2, comparative example 3 and control group are high；Wherein, the score value of embodiment 2 is even more and organizes that significant difference (P < 0.05) is presented with other
Product Status, flavor taste are all preferable on the whole to embodiment 3 for embodiment 1.It can be seen that soyabean protein powder, xylitol, sweet orange
Juice powder, mangosteen powder also have an impact to the state of Lactobacillus rhamnosus, bifidobacterium lactis, flavor taste.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
Limitations on the scope of the patent of the present invention therefore cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to guarantor of the invention
Protect range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of composition for alleviating stomachache gastric acid, antidiarrheal defaecation, which is characterized in that in terms of mass fraction,
It is described alleviate stomachache gastric acid, the raw material of composition of antidiarrheal defaecation includes:
0.1 part~10 parts of Lactobacillus rhamnosus；
0.1 part~5 parts of bifidobacterium lactis；And
15 parts~45 parts of soybean protein.
2. the composition according to claim 1 for alleviating stomachache gastric acid, antidiarrheal defaecation, which is characterized in that with mass fraction
Meter, it is described alleviate stomachache gastric acid, the raw material of composition of antidiarrheal defaecation further includes prebiotics, the number of the prebiotics is 0.06
Part~30 parts.
3. the composition according to claim 2 for alleviating stomachache gastric acid, antidiarrheal defaecation, which is characterized in that with mass fraction
Meter, it is described alleviate stomachache gastric acid, the raw material of composition of antidiarrheal defaecation includes:
4. the composition according to claim 2 for alleviating stomachache gastric acid, antidiarrheal defaecation, which is characterized in that the prebiotics
Selected from least one of oligofructose, resistant dextrin and lactitol.
5. the composition according to claim 4 for alleviating stomachache gastric acid, antidiarrheal defaecation, which is characterized in that the prebiotics
For the mixture of oligofructose, resistant dextrin and lactitol, wherein in terms of mass fraction, the oligofructose is 0.5 part~3
Part, the resistant dextrin is 0.06 part~24 parts, and the lactitol is 0.5 part~3 parts.
6. described in any item compositions for alleviating stomachache gastric acid, antidiarrheal defaecation according to claim 1~5, which is characterized in that with
Mass fraction meter, it is described alleviate stomachache gastric acid, antidiarrheal defaecation composition raw material include 30 parts~70 parts xylitol, 3 parts
At least one of~15 portions of sweet oranges and 0.5 part~10 portions of Siraitia grosvenoriis.
7. the described in any item preparation methods for alleviating gastric acid of having a stomachache, the composition of antidiarrheal defaecation of claim 1~6, feature
It is, comprising the following steps:
The raw material of the described alleviation stomachache gastric acid, the composition of antidiarrheal defaecation is uniformly mixed, obtain alleviations have a stomachache gastric acid,
The composition of antidiarrheal defaecation.
8. the described in any item compositions or as claimed in claim 7 for alleviating stomachache gastric acid, antidiarrheal defaecation of claim 1~6
Alleviate stomachache gastric acid, antidiarrheal defaecation composition preparation method obtain alleviation stomachache gastric acid, antidiarrheal defaecation composition exist
Prepare food or preparation alleviate stomachache gastric acid, antidiarrheal defaecation drug in application.
9. a kind of food, which is characterized in that alleviate stomachache gastric acid, antidiarrheal defaecation including claim 1~6 is described in any item
Composition or it is as claimed in claim 7 alleviate stomachache gastric acid, antidiarrheal defaecation composition preparation method obtain alleviation stomachache
Gastric acid, antidiarrheal defaecation composition and food on acceptable auxiliary material.
10. a kind of drug, which is characterized in that including claim 1~6 described in any item alleviations stomachache gastric acids, antidiarrheal defaecation
Composition or it is as claimed in claim 7 alleviate stomachache gastric acid, antidiarrheal defaecation composition the obtained alleviation stomach of preparation method
Pain gastric acid, antidiarrheal defaecation composition and pharmaceutically acceptable auxiliary material.
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