CN109453231A - A kind of drug and its preparation method and application for treating rheumatoid arthritis - Google Patents
A kind of drug and its preparation method and application for treating rheumatoid arthritis Download PDFInfo
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The present invention relates to field of Chinese medicinal composition, provide a kind of drug and its preparation method and application for treating rheumatoid arthritis.The drug of the treatment rheumatoid arthritis, its component includes Radix Astragali, tetrandra root, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, scorpio and centipede, wherein, Radix Astragali, tetrandra root, Rhizoma Atractylodis Macrocephalae and the mass ratio of Radix Glycyrrhizae are 10:5-8:5-8:5-8, and Radix Astragali, tetrandra root, Rhizoma Atractylodis Macrocephalae and the mixture of Radix Glycyrrhizae are 0.2~0.25:1~3:1~3 with the mass ratio of scorpio and centipede.A kind of preparation method of drug that treating rheumatoid arthritis comprising be uniformly mixed the component for treating the drug of rheumatoid arthritis.Each component complements each other, and mutually cooperates with, and has preferable therapeutic effect to rheumatoid arthritis disease.
Description
Technical field
The present invention relates to field of Chinese medicinal composition, in particular to a kind of drug for treating rheumatoid arthritis and its
Preparation method and application.
Background technique
Rheumatoid arthritis (RA) is a kind of unknown systemic disease chronic, based on inflammatory synovitis of cause of disease.Its
It is characterized in hand, the multi-joint of sufficient Minor articulus, symmetry, aggressive arthritis, is often accompanied by organ outside joint and is involved serum
Rheumatoid factor positive can cause joint deformity and function to be lost.The drug for the treatment of rheumatoid arthritis in the prior art
Unsatisfactory curative effect.
Summary of the invention
The purpose of the present invention can effectively treat class for example including a kind of drug for treating rheumatoid arthritis is provided
Rheumathritis alleviates its pain symptom.
The purpose of the present invention further includes providing a kind of preparation method of drug for treating rheumatoid arthritis, the preparation method
Simply, easy to accomplish.
The purpose of the present invention further includes providing a kind of application of drug for treating rheumatoid arthritis, can be efficiently applied to
In the drug of all kinds for the treatment of rheumatoid arthritis.
The embodiment of the present invention is achieved in that
A kind of drug for treating rheumatoid arthritis, component include Radix Astragali, tetrandra root, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, scorpio and centipede,
Wherein, Radix Astragali, tetrandra root, Rhizoma Atractylodis Macrocephalae and the mass ratio of Radix Glycyrrhizae are 10:5-8:5-8:5-8, Radix Astragali, tetrandra root, Rhizoma Atractylodis Macrocephalae and the mixing of Radix Glycyrrhizae
Object and the mass ratio of scorpio and centipede are 0.2~0.25:1~3:1~3.
A kind of preparation method of drug that treating rheumatoid arthritis comprising the drug of rheumatoid arthritis will be treated
Component is uniformly mixed.
Treat application of the drug of rheumatoid arthritis in the drug for the treatment of rheumatoid arthritis.
The beneficial effect of the embodiment of the present invention includes:
Compatibe drug provided in this embodiment and usage ratio to rheumatoid arthritis patients have apparent analgesia, it is anti-inflammatory,
The effect of detumescence, using scorpio and centipede as monarch drug in a prescription, Radix Astragali can liver protecting, as ministerial drug, and tetrandra root can inducing diuresis for removing edema,
Wind-expelling pain-stopping；Rhizoma Atractylodis Macrocephalae equally can alleviating edemas, and have certain antibiotic effect, tetrandra root and Rhizoma Atractylodis Macrocephalae collectively as adjutant,
And Radix Glycyrrhizae can coordinating the drug actions of a prescription, as making medicine.And the edema phenomenon that Radix Glycyrrhizae may cause can also be effectively relieved in tetrandra root and Rhizoma Atractylodis Macrocephalae,
Each component complements each other, and mutually cooperates with, and has preferable therapeutic effect to rheumatoid arthritis disease.Further it is provided that system
Preparation Method is simple, can effectively keep the effective component of each component, there is preferable treatment to make rheumatoid arthritis disease
With.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
The drug and its preparation method and application of the treatment rheumatoid arthritis of the embodiment of the present invention is carried out below specific
Explanation.
Present embodiments provide a kind of drug for treating rheumatoid arthritis, component includes Radix Astragali, tetrandra root, Rhizoma Atractylodis Macrocephalae, sweet
Grass, scorpio and centipede, wherein Radix Astragali, tetrandra root, Rhizoma Atractylodis Macrocephalae and the mass ratio of Radix Glycyrrhizae are 10:5-8:5-8:5-8, Radix Astragali, tetrandra root, white
The mixture of art and Radix Glycyrrhizae and the mass ratio of scorpio and centipede are 0.2~0.25:1~3:1~3.
Wherein, Radix Astragali, nature and flavor: sweet, tepor.Channel tropism: return lung, spleen, liver and kidney channel.Have enhancing body's immunity, liver protection,
Diuresis, anti-aging, resisting stress, decompression and wide antibacterial action, while osteoporosis can also be alleviated.
Tetrandra root, bitter；It is pungent；It is cold in nature；Return bladder；Lung；The spleen channel.It being capable of inducing diuresis for removing edema；Wind-expelling pain-stopping, brothers' pain, urine are not
Benefit；Rheumatic arthralgia；Tinea pedis swelling and pain；Scabies sore swells；High blood pressure etc..
Rhizoma Atractylodis Macrocephalae, bitter is sweet, warm-natured.Returns spleen, stomach meridian.It can strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, alleviating edemas, spontaneous perspiration, energy
Enough invigorating the spleen, stomach function regulating, diuresis and antibacterial.
Radix Glycyrrhizae is used for the heart qi deficiency, palpitation and severe palpitation, knotted pulse and deficiency of spleen-QI and stomach-QI, fatigue and weakness etc., for having a stomachache, abdominal pain
And gastrocnemius contraction urgency pain etc., other drugs for reconciling in this implementation it is strong, Radix Glycyrrhizae there are also anti-inflammatory, anti-allergic effects,
Long term usage large dosage Radix Glycyrrhizae, can cause edema.
Scorpio, nature and flavor are pungent, put down；Return liver warp；Can relieve the wind syndrome antispastic, remove obstruction in channels to relieve pain, dispersing pathogen accumulation.For liver wind agitation, convulsion
Contraction twitch, child convulsion, middle air portHemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, sore, scrofula.
Centipede, nature and flavor are acrid in flavour and warm in nature；Return liver warp.Can relieve the wind syndrome antispastic, remove obstruction in channels to relieve pain, dispersing pathogen accumulation.For liver wind agitation, convulsion
Contraction twitch, child convulsion, apoplexy, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, sore, scrofula, snakebite and bugbite.
Since scorpio and centipede have relieve the wind syndrome antispastic, remove obstruction in channels to relieve pain, the effect of dispersing pathogen accumulation, and centipede bends anti-angle
, the tetanic good effect of spasm, and scorpio is for twitching again and again, brothers tremble, and head shakes that effect is good, and Papillary can be mutual
Enhance therapeutic effect, arthralgia can be effectively relieved.
In the present embodiment, using scorpio and centipede as monarch drug in a prescription, Radix Astragali can liver protecting, as ministerial drug, and tetrandra root can
Inducing diuresis for removing edema, wind-expelling pain-stopping；Rhizoma Atractylodis Macrocephalae equally can alleviating edemas, and have certain antibiotic effect, tetrandra root and Rhizoma Atractylodis Macrocephalae are common
As adjutant, and Radix Glycyrrhizae can coordinating the drug actions of a prescription, as making medicine.And tetrandra root and Rhizoma Atractylodis Macrocephalae can also be effectively relieved what Radix Glycyrrhizae may cause
Edema phenomenon, each component complement each other, and mutually cooperate with, curative effect is more preferably.
Further, Radix Astragali, tetrandra root, Rhizoma Atractylodis Macrocephalae and the mass ratio of Radix Glycyrrhizae are 10:6-8:6-8:6-8, Radix Astragali, tetrandra root, Rhizoma Atractylodis Macrocephalae
It is 0.21~0.23:1.5~2.5:1.5~2.5 with the mixture of Radix Glycyrrhizae and the mass ratio of scorpio and centipede.
Further, Radix Astragali, tetrandra root, Rhizoma Atractylodis Macrocephalae and the mass ratio of Radix Glycyrrhizae are 10:7:7:7, Radix Astragali, tetrandra root, Rhizoma Atractylodis Macrocephalae and sweet
The mixture of grass and the mass ratio of scorpio and centipede are 0.22:1.5~2.5:1.5~2.5.
In other embodiments of the invention, the component of the drug of the treatment rheumatoid arthritis only includes Radix Astragali, prevents
, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, scorpio and centipede, component is few, and the mutual cooperation and mutual synergy between each component become apparent from.
In addition, additionally providing the preparation method of the drug of above-mentioned treatment rheumatoid arthritis in the present embodiment comprising will
The component for treating the drug of rheumatoid arthritis is uniformly mixed.
Specifically, Radix Astragali, tetrandra root, Rhizoma Atractylodis Macrocephalae and Radix Glycyrrhizae are endured through decocting, obtains extracting solution, extracting solution is concentrated and dried and is obtained
Mixed powder is obtained, smashed scorpio and centipede are uniformly mixed with mixed powder.The operating method is simple, easy to accomplish, by medium-height grass
Medicine is decocted, its effective component can be given full play to, and scorpio and centipede mix after directly beating powder without decocting,
Scorpio and centipede, which are directly beaten powder, can effectively keep the effective component of scorpio and centipede, be maximally maintained scorpio and centipede
Dosage, curative effect is more preferably.
It is tight to its used in amounts with certain toxicity, therefore when preparing due to scorpio and centipede term insect medicine
Lattice control, the scorpio and centipede dosage in the present embodiment are few, belong to the effective amount ranges of overall safety, compared to the prior art
In directly decoct for, in the present embodiment, by the way that other traditional Chinese medicinal components are decocted, the powder of acquisition again with directly crush it is complete
Scorpion and centipede are mixed, and can effectively avoid decocting destruction of the process high temperature to the foreign protein of scorpio and centipede, effectively
It ensure that effective quantity, and then reduce dosage.
In other embodiments of the invention, Radix Astragali, tetrandra root, Rhizoma Atractylodis Macrocephalae and Radix Glycyrrhizae are endured through decocting, obtains extracting solution, it will
Smashed scorpio and centipede are uniformly mixed with extracting solution, after impregnating 0.5-1h, are concentrated and dried jointly.In other of the invention
In embodiment, by mixing smashed scorpio and centipede with extracting solution, extracting solution has certain temperature, can reinforce powder
Scorpio and centipede and other components after broken are mutually mixed, but not destroy the foreign protein of scorpio and centipede, are effectively ensured
Effective quantity, and then reduce dosage.
Wherein, when adding water to cook to extract Radix Astragali, tetrandra root, Rhizoma Atractylodis Macrocephalae and Radix Glycyrrhizae, by adding water to cook three times, each 0.5-
1.5h merges multiple decoction liquor and obtains extracting solution.Repeatedly decocting being capable of extracting the effective component in component compared with limits
Come, the effective component of the extracting solution of acquisition is high.
Further, through inventor the study found that scorpio and centipede are smashed it through 100-140 mesh, can guarantee complete
Scorpion and centipede are easier to be uniformly mixed with other components.
In addition, the embodiment of the invention also provides the drugs of the treatment rheumatoid arthritis in treatment rheumatoid arthritis
Application in drug.
With reference to embodiments to drug for the treatment of rheumatoid arthritis of the invention and its preparation method and application into one
Step is illustrated.
Embodiment 1
Present embodiments provide a kind of drug for treating rheumatoid arthritis, preparation method is as follows: by Radix Astragali, tetrandra root,
Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae are uniformly mixed with mass ratio for the ratio of 10:5:5:5, and decocting is added to endure three times, each 0.5h, combined extract, will
Extracting solution, which is concentrated and dried, obtains mixed-powder；Scorpio and centipede are crushed to 100 mesh, by scorpion powder 1g, centipede powder 1g and mixed
It closes powder 0.2g and is packed into No. 1 capsule, each oral capsule 1 after mixing.
Embodiment 2
Present embodiments provide a kind of drug for treating rheumatoid arthritis, preparation method is as follows: by Radix Astragali, tetrandra root,
Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae are uniformly mixed with mass ratio for the ratio of 10:6:6:6, add decocting to endure three times, each 1h, combined extract will mention
It takes liquid to be concentrated and dried and obtains mixed-powder；Scorpio and centipede are crushed to 120 mesh, by scorpion powder 1.5g, centipede powder 1.5g and
Mixed-powder 0.21g is packed into No. 1 capsule, each oral capsule 1 after mixing.
Embodiment 3
Present embodiments provide a kind of drug for treating rheumatoid arthritis, preparation method is as follows: by Radix Astragali, tetrandra root,
Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae are uniformly mixed with mass ratio for the ratio of 10:7:7:7, and decocting is added to endure three times, each 1.5h, combined extract, will
Extracting solution, which is concentrated and dried, obtains mixed-powder；Scorpio and centipede are crushed to 140 mesh, by scorpion powder 2g, centipede powder 2g and mixed
It closes powder 0.22g and is packed into No. 1 capsule, each oral capsule 1 after mixing.
Embodiment 4
Present embodiments provide a kind of drug for treating rheumatoid arthritis, preparation method is as follows: by Radix Astragali, tetrandra root,
Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae are uniformly mixed with mass ratio for the ratio of 10:8:8:8, add decocting to endure three times, each 1h, combined extract will mention
It takes liquid to be concentrated and dried and obtains mixed-powder；Scorpio and centipede are crushed to 140 mesh, by scorpion powder 3g, centipede powder 3g and mixing
Powder 0.25g is packed into No. 1 capsule, each oral capsule 1 after mixing.
Embodiment 5
Present embodiments provide a kind of drug for treating rheumatoid arthritis, preparation method is as follows: by Radix Astragali, tetrandra root,
Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae are uniformly mixed with mass ratio for the ratio of 10:8:5:5, and decocting is added to endure three times, each 1.5h, combined extract, will
Extracting solution, which is concentrated and dried, obtains mixed-powder；Scorpio and centipede are crushed to 140 mesh, by scorpion powder 2.6g, centipede powder 2.6g with
And mixed-powder 0.23g is packed into No. 1 capsule, each oral capsule 1 after mixing.
Embodiment 6
Present embodiments provide a kind of drug for treating rheumatoid arthritis, preparation method is as follows: by Radix Astragali, tetrandra root,
Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae are uniformly mixed with mass ratio for the ratio of 10:8:6:6, add decocting to endure three times, each 1h, combined extract will mention
It takes liquid to be concentrated and dried and obtains mixed-powder；Scorpio and centipede are crushed to 120 mesh, by scorpion powder 2.4g, centipede powder 2.4g and
Mixed-powder 0.24g is packed into No. 1 capsule, each oral capsule 1 after mixing.
Embodiment 7
Present embodiments provide a kind of drug for treating rheumatoid arthritis, preparation method is as follows: by Radix Astragali, tetrandra root,
Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae are uniformly mixed with mass ratio for the ratio of 10:5:8:8, add decocting to endure secondary twice, each 1.5h, combined extract,
Extracting solution is concentrated and dried and obtains mixed-powder；Scorpio and centipede are crushed to 100 mesh, by scorpion powder 1.6g, centipede powder 1.6g
And mixed-powder 0.21g is packed into No. 1 capsule, each oral capsule 1 after mixing.
Embodiment 8
Present embodiments provide a kind of drug for treating rheumatoid arthritis, preparation method is as follows: by Radix Astragali, tetrandra root,
Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae are uniformly mixed with mass ratio for the ratio of 10:8:5:5, add decocting to endure three times, each 1h, combined extract will mention
It takes liquid to be concentrated and dried and obtains mixed-powder；Scorpio and centipede are crushed to 120 mesh, by scorpion powder 1.8g, centipede powder 1.8g and
Mixed-powder 0.22g is packed into No. 1 capsule, each oral capsule 1 after mixing.
Embodiment 9
Present embodiments provide a kind of drug for treating rheumatoid arthritis, preparation method is as follows: by Radix Astragali, tetrandra root,
Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae are uniformly mixed with mass ratio for the ratio of 10:8:6:7, add decocting to endure three times, each 1h, combined extract will mention
It takes liquid to be concentrated and dried and obtains mixed-powder；Scorpio and centipede are crushed to 120 mesh, by scorpion powder 2.1g, centipede powder 2.1g and
Mixed-powder 0.24g is packed into No. 1 capsule, each oral capsule 1 after mixing.
Embodiment 10
Present embodiments provide a kind of drug for treating rheumatoid arthritis, preparation method is as follows: by Radix Astragali, tetrandra root,
Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae are uniformly mixed with mass ratio for the ratio of 10:8:7:6, add decocting to endure three times, each 1h, combined extract will mention
It takes liquid to be concentrated and dried and obtains mixed-powder；Scorpio and centipede are crushed to 120 mesh, by scorpion powder 2.8g, centipede powder 2.8g and
Mixed-powder 0.25g is packed into No. 1 capsule, each oral capsule 1 after mixing.
Test example 1
500 treatment rheumatoid arthritis patients are in the drug 15 for taking treatment rheumatoid arthritis provided in this embodiment
After it, 462 patient articular's pain reliefs, anchylosis situation is reduced, and arthroncus situation is alleviated；Continue to take 15 days
Afterwards, 486 patient articular's pain are controlled, anchylosis improving situation, and no obvious arthroncus is able to alleviation effective percentage and is
97.2%.
The drug (Diclofenac) of other conventional therapy rheumatoid arthritis is compared on the market,
| Example | Recovery from illness | Effectively | In vain |
| Embodiment 3 | 486 | 10 | 4 |
| Existing drug | 413 | 37 | 50 |
Test example 2
One is taken orally every time with the capsule that embodiment 3 provides, and twice daily, is continuously taken 3 weeks, and starch is set, is disappeared
Scorching medicine and dexamethasone are control group, carry out clinical observation with double-blind study.
Curative effect: Clinical double-blind result of study is carried out to 100 patients with active and shows treatment class wind provided in this embodiment
Wet arthritic drug has the therapeutic effect of highly significant under Normal therapeutic dose to rheumatoid arthritis in active stage, stops
Bitterly, detumescence effect is better than dexamethasone, and grip can be remarkably reinforced and improve function of joint, there is conspicuousness compared with Dexamethasone group
Difference, can significantly reduce patient's erythrocyte sedimentation rate and mucin, and effect is better than dexamethasone；It can significantly reduce IgG, IgA, IgM level,
It is better than dexamethasone to the reduction effect of IgG level, can significantly improve C3、C4、CH50Level, and dexamethasone and indocin
Group improves unobvious；There is the apparent effect of turning out cloudy to rheumatoid factor；The significant regulatory T-cell subgroup of energy, is T4/T8Ratio restores
Normally, and dexamethasone make T cell aggregate level decline, T4/T8Ratio improves unobvious.It is evaluated in conjunction with anti-inflammatory efficacy, this implementation
The effect of the drug for the treatment rheumatoid arthritis that example provides be better than indocin and with dexamethasone indifference.
In conclusion compatibe drug provided in this embodiment and usage ratio have apparent town to rheumatoid arthritis patients
Bitterly, anti-inflammatory, detumescence effect, using scorpio and centipede as monarch drug in a prescription, Radix Astragali can liver protecting, as ministerial drug, and tetrandra root can
Inducing diuresis for removing edema, wind-expelling pain-stopping；Rhizoma Atractylodis Macrocephalae equally can alleviating edemas, and have certain antibiotic effect, tetrandra root and Rhizoma Atractylodis Macrocephalae are common
As adjutant, and Radix Glycyrrhizae can coordinating the drug actions of a prescription, as making medicine.And tetrandra root and Rhizoma Atractylodis Macrocephalae can also be effectively relieved what Radix Glycyrrhizae may cause
Edema phenomenon, each component complement each other, and mutually cooperate with, and have preferable therapeutic effect to rheumatoid arthritis disease.In addition,
The preparation method of offer is simple, can effectively keep the effective component of each component, has to rheumatoid arthritis disease preferable
Therapeutic effect.
These are only the preferred embodiment of the present invention, is not intended to restrict the invention, for those skilled in the art
For member, the invention may be variously modified and varied.All within the spirits and principles of the present invention, it is made it is any modification,
Equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of drug for treating rheumatoid arthritis, which is characterized in that its component includes Radix Astragali, tetrandra root, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, complete
Scorpion and centipede, wherein the Radix Astragali, the tetrandra root, the Rhizoma Atractylodis Macrocephalae and the mass ratio of the Radix Glycyrrhizae are 10:5-8:5-8:5-8, institute
The mass ratio for stating Radix Astragali, the tetrandra root, the Rhizoma Atractylodis Macrocephalae and the mixture of the Radix Glycyrrhizae and the scorpio and the centipede is 0.2~
0.25:1~3:1~3.
2. it is according to claim 1 treatment rheumatoid arthritis drug, which is characterized in that the Radix Astragali, the tetrandra root,
The Rhizoma Atractylodis Macrocephalae and the mass ratio of the Radix Glycyrrhizae are 10:6-8:6-8:6-8, the Radix Astragali, the tetrandra root, the Rhizoma Atractylodis Macrocephalae and described sweet
The mixture of grass and the mass ratio of the scorpio and the centipede are 0.21~0.23:1.5~2.5:1.5~2.5.
3. it is according to claim 1 treatment rheumatoid arthritis drug, which is characterized in that the Radix Astragali, the tetrandra root,
The Rhizoma Atractylodis Macrocephalae and the mass ratio of the Radix Glycyrrhizae are 10:7:7:7, the Radix Astragali, the tetrandra root, the Rhizoma Atractylodis Macrocephalae and the Radix Glycyrrhizae it is mixed
The mass ratio for closing object and the scorpio and the centipede is 0.22:1.5~2.5:1.5~2.5.
4. the drug for the treatment of rheumatoid arthritis according to claim 1, which is characterized in that the component only includes Huang
Stilbene, tetrandra root, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, scorpio and centipede.
5. a kind of preparation method of the drug for the treatment of rheumatoid arthritis according to any one of claims 1-4, feature exist
In comprising the component of the drug of the treatment rheumatoid arthritis is uniformly mixed.
6. the preparation method of the drug for the treatment of rheumatoid arthritis according to claim 5, which is characterized in that by the Huang
Stilbene, the tetrandra root, the Rhizoma Atractylodis Macrocephalae and the Radix Glycyrrhizae are endured through decocting, obtain extracting solution, the extracting solution is concentrated and dried acquisition
The smashed scorpio and the centipede are uniformly mixed by mixed powder with the mixed powder.
7. the preparation method of the drug for the treatment of rheumatoid arthritis according to claim 5, which is characterized in that by the Huang
Stilbene, the tetrandra root, the Rhizoma Atractylodis Macrocephalae and the Radix Glycyrrhizae are endured through decocting, extracting solution are obtained, by the smashed scorpio and the Wu
Centipede is uniformly mixed with the extracting solution, after impregnating 0.5-1h, is concentrated and dried jointly.
8. the drug for the treatment of rheumatoid arthritis according to claim 6 or 7, which is characterized in that the scorpio and described
Centipede smashes it through 100-140 mesh.
9. the drug for the treatment of rheumatoid arthritis according to claim 6 or 7, which is characterized in that by the Radix Astragali, described
Tetrandra root, the Rhizoma Atractylodis Macrocephalae and the Radix Glycyrrhizae are endured through decocting including adding water to cook three times, each 0.5-1.5h, are merged multiple decoction liquor and are obtained
Obtain the extracting solution.
10. the drug for the treatment of rheumatoid arthritis according to claim 1-4 is in treatment rheumatoid arthritis
Application in drug.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811560787.1A CN109453231A (en) | 2018-12-19 | 2018-12-19 | A kind of drug and its preparation method and application for treating rheumatoid arthritis |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899598A (en) * | 2006-07-19 | 2007-01-24 | 李永胜 | Combined medicine for preventing and treating rheumatism, rheumatoid, protrusion of intervertebral disc and hyperosteogeny |
| WO2007013824A1 (en) * | 2005-07-28 | 2007-02-01 | Sa Pa Indigenous Medicinal Plants Association | Biologically active extracts from stephania brachyandra |
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2018
- 2018-12-19 CN CN201811560787.1A patent/CN109453231A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007013824A1 (en) * | 2005-07-28 | 2007-02-01 | Sa Pa Indigenous Medicinal Plants Association | Biologically active extracts from stephania brachyandra |
| CN1899598A (en) * | 2006-07-19 | 2007-01-24 | 李永胜 | Combined medicine for preventing and treating rheumatism, rheumatoid, protrusion of intervertebral disc and hyperosteogeny |
Non-Patent Citations (2)
| Title |
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| 王绪辉: "防己黄芪汤提取物治疗活动期类风湿性关节炎的临床药效评估", 《中医杂志》 * |
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Application publication date: 20190312 |